Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.211 0.332 -9999.0 0.0 -0.593 47.0 47.0 IHH -0.03 0.063 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.01 0.062 -9999.0 0.0 -0.456 2.0 2.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.009 0.061 0.452 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.078 0.165 -9999.0 0.0 -0.376 2.0 2.0 SMO -0.089 0.173 -9999.0 0.0 -0.401 2.0 2.0 AKT1 -0.025 0.091 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.14 -9999.0 0.0 -0.751 4.0 4.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.088 0.171 -9999.0 0.0 -0.396 2.0 2.0 STIL -0.063 0.133 -9999.0 0.0 -0.343 2.0 2.0 DHH N/PTCH2 -0.019 0.149 -9999.0 0.0 -0.568 8.0 8.0 DHH N/PTCH1 -0.103 0.19 -9999.0 0.0 -0.556 7.0 7.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.019 0.155 -9999.0 0.0 -0.751 5.0 5.0 PTHLH -0.431 0.591 -9999.0 0.0 -1.139 47.0 47.0 determination of left/right symmetry -0.088 0.171 -9999.0 0.0 -0.396 2.0 2.0 PIK3R1 0.008 0.071 -9999.0 0.0 -0.751 1.0 1.0 skeletal system development -0.422 0.58 -9999.0 0.0 -1.117 47.0 47.0 IHH N/Hhip -0.121 0.247 -9999.0 0.0 -0.629 22.0 22.0 DHH N/Hhip -0.115 0.257 -9999.0 0.0 -0.586 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.088 0.171 -9999.0 0.0 -0.396 2.0 2.0 pancreas development -0.131 0.299 -9999.0 0.0 -0.749 22.0 22.0 HHAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.055 -9999.0 0.0 -0.568 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.1 -9999.0 0.0 -0.751 2.0 2.0 somite specification -0.088 0.171 -9999.0 0.0 -0.396 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.072 0.139 -9999.0 0.0 -0.367 2.0 2.0 SHH Np/Cholesterol/PTCH2 0.005 0.075 -9999.0 0.0 -0.456 3.0 3.0 SHH Np/Cholesterol/Megalin 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.103 0.178 -9999.0 0.0 -0.316 47.0 47.0 SMO/Vitamin D3 -0.074 0.153 -9999.0 0.0 -0.368 2.0 2.0 SHH Np/Cholesterol/Hhip -0.072 0.185 -9999.0 0.0 -0.456 22.0 22.0 LRP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.071 0.149 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.001 0.086 -9999.0 0.0 -0.456 4.0 4.0 SHH Np/Cholesterol/CDO 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.072 0.184 0.452 22.0 -9999.0 0.0 22.0 mol:Vitamin D3 -0.071 0.142 -9999.0 0.0 -0.368 2.0 2.0 IHH N/PTCH2 -0.017 0.103 -9999.0 0.0 -0.618 3.0 3.0 CDON 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.103 0.18 -9999.0 0.0 -0.318 47.0 47.0 Megalin/LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 -0.005 0.121 -9999.0 0.0 -0.751 3.0 3.0 SHH Np/Cholesterol 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.103 0.179 -9999.0 0.0 -0.317 47.0 47.0 HHIP -0.131 0.3 -9999.0 0.0 -0.751 22.0 22.0