Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	34.0	3078.0	88.0	-0.636	0.106	1000.0	-1000.0	-0.076	-1000.0
Class IB PI3K non-lipid kinase events	33.0	99.0	3.0	-0.203	-1000.0	1000.0	-1000.0	-0.003	-1000.0
Nongenotropic Androgen signaling	32.0	1676.0	52.0	-0.493	0.313	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-alpha and p38-beta	31.0	1406.0	44.0	-0.46	0.015	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	27.0	1212.0	44.0	-0.725	0.042	1000.0	-1000.0	-0.033	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	26.0	907.0	34.0	-0.242	0.015	1000.0	-1000.0	-0.031	-1000.0
IL4-mediated signaling events	24.0	2210.0	91.0	-0.951	0.597	1000.0	-1000.0	-0.107	-1000.0
IL6-mediated signaling events	23.0	1755.0	75.0	-0.388	0.044	1000.0	-1000.0	-0.052	-1000.0
Reelin signaling pathway	22.0	1268.0	56.0	-0.33	0.027	1000.0	-1000.0	-0.057	-1000.0
Endothelins	22.0	2156.0	96.0	-0.62	0.063	1000.0	-1000.0	-0.06	-1000.0
Calcium signaling in the CD4+ TCR pathway	22.0	682.0	31.0	-0.517	0.015	1000.0	-1000.0	-0.052	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	21.0	1489.0	68.0	-0.62	0.109	1000.0	-1000.0	-0.089	-1000.0
Thromboxane A2 receptor signaling	19.0	2017.0	105.0	-0.28	0.082	1000.0	-1000.0	-0.051	-1000.0
Signaling events regulated by Ret tyrosine kinase	18.0	1546.0	82.0	-0.401	0.015	1000.0	-1000.0	-0.074	-1000.0
IL23-mediated signaling events	16.0	988.0	60.0	-0.64	0.021	1000.0	-1000.0	-0.119	-1000.0
Osteopontin-mediated events	15.0	592.0	38.0	-0.388	0.017	1000.0	-1000.0	-0.068	-1000.0
TCGA08_retinoblastoma	15.0	124.0	8.0	-0.075	0.047	1000.0	-1000.0	-0.012	-1000.0
FOXM1 transcription factor network	14.0	730.0	51.0	-0.577	0.017	1000.0	-1000.0	-0.132	-1000.0
Ras signaling in the CD4+ TCR pathway	13.0	224.0	17.0	-0.249	0.013	1000.0	-1000.0	-0.025	-1000.0
Noncanonical Wnt signaling pathway	12.0	332.0	26.0	-0.224	0.015	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	12.0	666.0	52.0	-0.32	0.05	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	11.0	902.0	76.0	-0.45	0.03	1000.0	-1000.0	-0.033	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	620.0	54.0	-0.33	0.028	1000.0	-1000.0	-0.071	-1000.0
JNK signaling in the CD4+ TCR pathway	11.0	187.0	17.0	-0.142	0.015	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	11.0	852.0	76.0	-0.453	0.024	1000.0	-1000.0	-0.062	-1000.0
Fc-epsilon receptor I signaling in mast cells	11.0	1142.0	97.0	-0.388	0.033	1000.0	-1000.0	-0.07	-1000.0
Glucocorticoid receptor regulatory network	11.0	1274.0	114.0	-0.611	0.22	1000.0	-1000.0	-0.051	-1000.0
Wnt signaling	11.0	83.0	7.0	-0.216	0.013	1000.0	-1000.0	-0.013	-1000.0
BCR signaling pathway	11.0	1176.0	99.0	-0.276	0.026	1000.0	-1000.0	-0.064	-1000.0
amb2 Integrin signaling	10.0	840.0	82.0	-0.34	0.02	1000.0	-1000.0	-0.056	-1000.0
S1P1 pathway	10.0	387.0	36.0	-0.373	0.015	1000.0	-1000.0	-0.04	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	977.0	93.0	-0.175	0.03	1000.0	-1000.0	-0.067	-1000.0
ErbB2/ErbB3 signaling events	9.0	630.0	65.0	-0.269	0.021	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by the Hedgehog family	9.0	483.0	52.0	-0.431	0.072	1000.0	-1000.0	-0.021	-1000.0
Arf6 signaling events	9.0	580.0	62.0	-0.362	0.03	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PTP1B	9.0	691.0	76.0	-0.337	0.024	1000.0	-1000.0	-0.059	-1000.0
Retinoic acid receptors-mediated signaling	9.0	561.0	58.0	-0.302	0.03	1000.0	-1000.0	-0.054	-1000.0
Integrins in angiogenesis	9.0	764.0	84.0	-0.168	0.023	1000.0	-1000.0	-0.062	-1000.0
PDGFR-beta signaling pathway	9.0	910.0	97.0	-0.163	0.015	1000.0	-1000.0	-0.065	-1000.0
BMP receptor signaling	8.0	717.0	81.0	-0.336	0.051	1000.0	-1000.0	-0.083	-1000.0
Glypican 1 network	8.0	415.0	48.0	-0.219	0.021	1000.0	-1000.0	-0.024	-1000.0
Regulation of Androgen receptor activity	8.0	577.0	70.0	-0.323	0.03	1000.0	-1000.0	-0.059	-1000.0
BARD1 signaling events	7.0	420.0	57.0	-0.111	0.075	1000.0	-1000.0	-0.028	-1000.0
FAS signaling pathway (CD95)	7.0	359.0	47.0	-0.508	0.042	1000.0	-1000.0	-0.025	-1000.0
Insulin Pathway	7.0	543.0	74.0	-0.493	0.039	1000.0	-1000.0	-0.069	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	7.0	913.0	120.0	-0.586	0.257	1000.0	-1000.0	-0.069	-1000.0
IL12-mediated signaling events	6.0	603.0	87.0	-0.698	0.031	1000.0	-1000.0	-0.109	-1000.0
Glypican 2 network	6.0	24.0	4.0	-0.038	-0.034	1000.0	-1000.0	-0.011	-1000.0
Syndecan-4-mediated signaling events	6.0	406.0	67.0	-0.324	0.025	1000.0	-1000.0	-0.046	-1000.0
Aurora B signaling	6.0	446.0	67.0	-0.494	0.025	1000.0	-1000.0	-0.051	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	715.0	136.0	-0.443	0.049	1000.0	-1000.0	-0.034	-1000.0
Syndecan-2-mediated signaling events	5.0	408.0	69.0	-0.324	0.023	1000.0	-1000.0	-0.019	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	27.0	5.0	-0.038	0.001	1000.0	-1000.0	-0.008	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	359.0	61.0	-0.388	0.045	1000.0	-1000.0	-0.073	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	241.0	46.0	-0.836	0.022	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	5.0	322.0	63.0	-0.119	0.033	1000.0	-1000.0	-0.05	-1000.0
IL27-mediated signaling events	5.0	283.0	51.0	-0.309	0.102	1000.0	-1000.0	-0.053	-1000.0
LPA4-mediated signaling events	4.0	50.0	12.0	-0.172	0.019	1000.0	-1000.0	-0.019	-1000.0
Syndecan-1-mediated signaling events	4.0	146.0	34.0	-0.22	0.015	1000.0	-1000.0	-0.037	-1000.0
IL2 signaling events mediated by PI3K	4.0	274.0	58.0	-0.215	0.029	1000.0	-1000.0	-0.062	-1000.0
LPA receptor mediated events	4.0	482.0	102.0	-0.388	0.027	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by PRL	4.0	143.0	34.0	-0.166	0.023	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	3.0	214.0	69.0	-0.21	0.038	1000.0	-1000.0	-0.07	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	305.0	85.0	-0.407	0.045	1000.0	-1000.0	-0.05	-1000.0
p75(NTR)-mediated signaling	3.0	479.0	125.0	-0.22	0.044	1000.0	-1000.0	-0.072	-1000.0
Ephrin B reverse signaling	3.0	171.0	48.0	-0.119	0.018	1000.0	-1000.0	-0.044	-1000.0
Regulation of p38-alpha and p38-beta	3.0	180.0	54.0	-0.104	0.038	1000.0	-1000.0	-0.042	-1000.0
IL2 signaling events mediated by STAT5	3.0	79.0	22.0	-0.064	0.018	1000.0	-1000.0	-0.029	-1000.0
IGF1 pathway	3.0	221.0	57.0	-0.029	0.03	1000.0	-1000.0	-0.073	-1000.0
Plasma membrane estrogen receptor signaling	3.0	296.0	86.0	-0.071	0.033	1000.0	-1000.0	-0.062	-1000.0
Rapid glucocorticoid signaling	3.0	61.0	20.0	-0.059	0.015	1000.0	-1000.0	-0.013	-1000.0
Visual signal transduction: Rods	3.0	189.0	52.0	-0.295	0.019	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	259.0	78.0	-0.117	0.044	1000.0	-1000.0	-0.051	-1000.0
Cellular roles of Anthrax toxin	2.0	82.0	39.0	-0.173	0.02	1000.0	-1000.0	-0.014	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	147.0	65.0	-0.038	0.058	1000.0	-1000.0	-0.042	-1000.0
Aurora C signaling	2.0	20.0	7.0	-0.051	0.0	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	109.0	37.0	-0.038	0.033	1000.0	-1000.0	-0.026	-1000.0
IL1-mediated signaling events	2.0	178.0	62.0	-0.092	0.062	1000.0	-1000.0	-0.069	-1000.0
HIF-2-alpha transcription factor network	2.0	122.0	43.0	-0.103	0.105	1000.0	-1000.0	-0.054	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	211.0	83.0	-0.178	0.067	1000.0	-1000.0	-0.051	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	107.0	36.0	-0.038	0.03	1000.0	-1000.0	-0.057	-1000.0
Atypical NF-kappaB pathway	2.0	81.0	31.0	-0.065	0.028	1000.0	-1000.0	-0.017	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	101.0	45.0	-0.078	0.061	1000.0	-1000.0	-0.066	-1000.0
Canonical Wnt signaling pathway	2.0	118.0	51.0	-0.143	0.049	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	311.0	125.0	-0.119	0.068	1000.0	-1000.0	-0.065	-1000.0
TCGA08_rtk_signaling	2.0	66.0	26.0	-0.256	0.034	1000.0	-1000.0	-0.014	-1000.0
Class I PI3K signaling events	2.0	160.0	73.0	-0.104	0.043	1000.0	-1000.0	-0.043	-1000.0
Regulation of Telomerase	2.0	216.0	102.0	-0.387	0.051	1000.0	-1000.0	-0.086	-1000.0
S1P3 pathway	2.0	105.0	42.0	-0.084	0.042	1000.0	-1000.0	-0.024	-1000.0
Caspase cascade in apoptosis	1.0	82.0	74.0	-0.045	0.039	1000.0	-1000.0	-0.023	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	34.0	23.0	-0.098	0.049	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	42.0	28.0	-0.025	0.036	1000.0	-1000.0	-0.019	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	0.001	0.008	1000.0	-1000.0	-0.012	-1000.0
Aurora A signaling	1.0	67.0	60.0	-0.039	0.046	1000.0	-1000.0	-0.017	-1000.0
PLK1 signaling events	1.0	165.0	85.0	-0.038	0.033	1000.0	-1000.0	-0.033	-1000.0
mTOR signaling pathway	1.0	57.0	53.0	-0.018	0.03	1000.0	-1000.0	-0.051	-1000.0
Ceramide signaling pathway	1.0	99.0	76.0	-0.075	0.043	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class III	1.0	40.0	40.0	-0.042	0.023	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class I	1.0	155.0	104.0	-0.056	0.056	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	16.0	15.0	0.0	0.025	1000.0	-1000.0	-0.019	-1000.0
Syndecan-3-mediated signaling events	1.0	52.0	35.0	-0.075	0.044	1000.0	-1000.0	-0.027	-1000.0
EPHB forward signaling	1.0	147.0	85.0	-0.223	0.039	1000.0	-1000.0	-0.071	-1000.0
Effects of Botulinum toxin	1.0	40.0	26.0	-0.072	0.025	1000.0	-1000.0	-0.044	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	53.0	33.0	-0.093	0.038	1000.0	-1000.0	-0.028	-1000.0
S1P4 pathway	1.0	35.0	25.0	-0.018	0.028	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	0.0	18.0	39.0	-0.045	0.086	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class II	0.0	66.0	75.0	-0.117	0.044	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Cones	0.0	5.0	38.0	-0.019	0.02	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	0.0	4.0	22.0	-0.013	0.048	1000.0	-1000.0	-0.021	-1000.0
Ephrin A  reverse signaling	0.0	0.0	7.0	-0.021	0.011	1000.0	-1000.0	-0.01	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.026	0.028	1000.0	-1000.0	-0.026	-1000.0
EPO signaling pathway	0.0	30.0	55.0	-0.008	0.075	1000.0	-1000.0	-0.067	-1000.0
Insulin-mediated glucose transport	0.0	1.0	32.0	-0.016	0.039	1000.0	-1000.0	-0.033	-1000.0
IFN-gamma pathway	0.0	16.0	68.0	-0.032	0.081	1000.0	-1000.0	-0.071	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	9.0	68.0	-0.04	0.054	1000.0	-1000.0	-0.029	-1000.0
TRAIL signaling pathway	0.0	42.0	48.0	-0.005	0.044	1000.0	-1000.0	-0.053	-1000.0
S1P5 pathway	0.0	5.0	17.0	-0.032	0.033	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	0.0	28.0	49.0	-0.044	0.041	1000.0	-1000.0	-0.026	-1000.0
TCGA08_p53	0.0	5.0	7.0	-0.005	0.015	1000.0	-1000.0	-0.009	-1000.0
FoxO family signaling	0.0	40.0	64.0	-0.045	0.132	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	59.0	74.0	-0.028	0.071	1000.0	-1000.0	-0.068	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	17.0	76.0	-0.006	0.059	1000.0	-1000.0	-0.063	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.038	1000.0	-1000.0	-0.042	-1000.0
Arf6 trafficking events	0.0	45.0	71.0	-0.079	0.044	1000.0	-1000.0	-0.05	-1000.0
EGFR-dependent Endothelin signaling events	0.0	18.0	21.0	-0.007	0.03	1000.0	-1000.0	-0.049	-1000.0
VEGFR1 specific signals	0.0	29.0	56.0	-0.032	0.062	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	0.0	36.0	43.0	-0.041	0.047	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.006	0.024	1000.0	-1000.0	-0.011	-1000.0
p38 MAPK signaling pathway	0.0	8.0	44.0	-0.032	0.031	1000.0	-1000.0	-0.051	-1000.0
Arf1 pathway	0.0	9.0	54.0	-0.005	0.029	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.043	1000.0	-1000.0	-0.015	-1000.0
Total	844	53266	7203	-28.1180456581	-993.872945265	131000	-131000	-5.82381017387	-131000