Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.084 0.19 0.381 33.0 -9999.0 0.0 33.0 KIRREL -0.118 0.24 -9999.0 0.0 -0.521 30.0 30.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.084 0.19 -9999.0 0.0 -0.382 33.0 33.0 PLCG1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.043 0.158 -9999.0 0.0 -0.289 33.0 33.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.055 0.126 -9999.0 0.0 -0.252 33.0 33.0 FYN -0.048 0.16 0.298 8.0 -0.273 33.0 41.0 mol:Ca2+ -0.043 0.157 -9999.0 0.0 -0.286 33.0 33.0 mol:DAG -0.042 0.158 -9999.0 0.0 -0.287 33.0 33.0 NPHS2 -0.008 0.039 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.042 0.158 -9999.0 0.0 -0.287 33.0 33.0 regulation of endocytosis -0.04 0.141 -9999.0 0.0 -0.258 33.0 33.0 Nephrin/NEPH1/podocin/Cholesterol -0.054 0.149 -9999.0 0.0 -0.286 33.0 33.0 establishment of cell polarity -0.084 0.19 -9999.0 0.0 -0.381 33.0 33.0 Nephrin/NEPH1/podocin/NCK1-2 -0.028 0.155 -9999.0 0.0 -0.266 33.0 33.0 Nephrin/NEPH1/beta Arrestin2 -0.039 0.143 -9999.0 0.0 -0.261 33.0 33.0 NPHS1 -0.014 0.116 -9999.0 0.0 -0.467 6.0 6.0 Nephrin/NEPH1/podocin -0.05 0.144 -9999.0 0.0 -0.274 33.0 33.0 TJP1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.042 0.159 -9999.0 0.0 -0.289 33.0 33.0 CD2AP 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.042 0.157 -9999.0 0.0 -0.288 32.0 32.0 GRB2 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.053 0.156 0.329 6.0 -0.266 34.0 40.0 cytoskeleton organization -0.071 0.143 0.205 2.0 -0.296 32.0 34.0 Nephrin/NEPH1 -0.057 0.135 -9999.0 0.0 -0.267 33.0 33.0 Nephrin/NEPH1/ZO-1 -0.055 0.163 -9999.0 0.0 -0.307 33.0 33.0