Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.198 0.287 -9999.0 0.0 -0.554 43.0 43.0 IHH -0.026 0.087 -9999.0 0.0 -0.163 5.0 5.0 SHH Np/Cholesterol/GAS1 0.019 0.034 -9999.0 0.0 -0.295 1.0 1.0 LRPAP1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.019 0.033 0.294 1.0 -9999.0 0.0 1.0 SMO/beta Arrestin2 -0.087 0.177 -9999.0 0.0 -0.413 5.0 5.0 SMO -0.1 0.176 -9999.0 0.0 -0.336 18.0 18.0 AKT1 -0.021 0.104 -9999.0 0.0 -0.678 1.0 1.0 ARRB2 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.1 -9999.0 0.0 -0.514 4.0 4.0 ADRBK1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.098 0.174 -9999.0 0.0 -0.332 18.0 18.0 STIL -0.071 0.148 0.305 1.0 -0.246 42.0 43.0 DHH N/PTCH2 0.023 0.095 -9999.0 0.0 -0.375 6.0 6.0 DHH N/PTCH1 -0.095 0.189 -9999.0 0.0 -0.31 46.0 46.0 PIK3CA 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.1 -9999.0 0.0 -0.514 4.0 4.0 PTHLH -0.363 0.482 -9999.0 0.0 -0.932 47.0 47.0 determination of left/right symmetry -0.098 0.174 -9999.0 0.0 -0.332 18.0 18.0 PIK3R1 0.027 0.051 -9999.0 0.0 -0.514 1.0 1.0 skeletal system development -0.358 0.476 -9999.0 0.0 -0.919 47.0 47.0 IHH N/Hhip -0.077 0.171 -9999.0 0.0 -0.42 21.0 21.0 DHH N/Hhip -0.045 0.178 -9999.0 0.0 -0.387 24.0 24.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.098 0.174 -9999.0 0.0 -0.332 18.0 18.0 pancreas development -0.067 0.211 -9999.0 0.0 -0.513 21.0 21.0 HHAT 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.043 0.041 -9999.0 0.0 -0.375 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.022 0.072 -9999.0 0.0 -0.514 2.0 2.0 somite specification -0.098 0.174 -9999.0 0.0 -0.332 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.082 0.141 -9999.0 0.0 -0.253 45.0 45.0 SHH Np/Cholesterol/PTCH2 0.017 0.043 -9999.0 0.0 -0.295 2.0 2.0 SHH Np/Cholesterol/Megalin 0.015 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.012 0.006 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.106 0.187 -9999.0 0.0 -0.327 46.0 46.0 SMO/Vitamin D3 -0.084 0.165 -9999.0 0.0 -0.282 43.0 43.0 SHH Np/Cholesterol/Hhip -0.019 0.105 -9999.0 0.0 -0.294 14.0 14.0 LRP2 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.086 0.159 -9999.0 0.0 -0.316 6.0 6.0 SHH Np/Cholesterol/BOC 0.011 0.059 -9999.0 0.0 -0.295 4.0 4.0 SHH Np/Cholesterol/CDO 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.019 0.105 0.292 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.061 0.172 0.377 4.0 -0.254 45.0 49.0 IHH N/PTCH2 -0.004 0.08 -9999.0 0.0 -0.411 2.0 2.0 CDON 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.102 0.19 -9999.0 0.0 -0.329 46.0 46.0 Megalin/LRPAP1 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.023 0.072 -9999.0 0.0 -0.514 2.0 2.0 SHH Np/Cholesterol 0.014 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.106 0.187 -9999.0 0.0 -0.328 46.0 46.0 HHIP -0.067 0.211 -9999.0 0.0 -0.514 21.0 21.0