Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	35.0	3164.0	88.0	-0.565	0.117	1000.0	-1000.0	-0.053	-1000.0
Signaling mediated by p38-alpha and p38-beta	32.0	1425.0	44.0	-0.35	0.032	1000.0	-1000.0	-0.012	-1000.0
Class IB PI3K non-lipid kinase events	32.0	96.0	3.0	-0.12	-1000.0	1000.0	-1000.0	-0.021	-1000.0
Nongenotropic Androgen signaling	31.0	1638.0	52.0	-0.443	0.282	1000.0	-1000.0	-0.024	-1000.0
Endothelins	26.0	2571.0	96.0	-0.581	0.056	1000.0	-1000.0	-0.035	-1000.0
PDGFR-alpha signaling pathway	25.0	1125.0	44.0	-0.571	0.058	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	23.0	2143.0	91.0	-0.9	0.592	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	21.0	1641.0	76.0	-0.31	0.048	1000.0	-1000.0	-0.03	-1000.0
Reelin signaling pathway	21.0	1227.0	56.0	-0.208	0.064	1000.0	-1000.0	-0.019	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	20.0	711.0	34.0	-0.118	0.033	1000.0	-1000.0	-0.023	-1000.0
Calcium signaling in the CD4+ TCR pathway	20.0	623.0	31.0	-0.359	0.032	1000.0	-1000.0	-0.038	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	20.0	1384.0	68.0	-0.505	0.107	1000.0	-1000.0	-0.055	-1000.0
IL6-mediated signaling events	19.0	1434.0	75.0	-0.244	0.057	1000.0	-1000.0	-0.026	-1000.0
Thromboxane A2 receptor signaling	18.0	1943.0	105.0	-0.261	0.076	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	18.0	1486.0	82.0	-0.267	0.051	1000.0	-1000.0	-0.042	-1000.0
IL23-mediated signaling events	16.0	998.0	60.0	-0.562	0.064	1000.0	-1000.0	-0.02	-1000.0
Osteopontin-mediated events	15.0	582.0	38.0	-0.244	0.035	1000.0	-1000.0	-0.019	-1000.0
FOXM1 transcription factor network	15.0	770.0	51.0	-0.56	0.033	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by the Hedgehog family	14.0	753.0	52.0	-0.363	0.043	1000.0	-1000.0	-0.016	-1000.0
Coregulation of Androgen receptor activity	13.0	990.0	76.0	-0.309	0.059	1000.0	-1000.0	-0.01	-1000.0
TCGA08_retinoblastoma	13.0	109.0	8.0	-0.027	0.029	1000.0	-1000.0	-0.002	-1000.0
Glucocorticoid receptor regulatory network	12.0	1388.0	114.0	-0.504	0.189	1000.0	-1000.0	-0.034	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	210.0	17.0	-0.196	0.042	1000.0	-1000.0	-0.017	-1000.0
IL12-mediated signaling events	11.0	1028.0	87.0	-0.6	0.086	1000.0	-1000.0	-0.032	-1000.0
amb2 Integrin signaling	11.0	945.0	82.0	-0.29	0.042	1000.0	-1000.0	-0.021	-1000.0
S1P1 pathway	11.0	414.0	36.0	-0.351	0.031	1000.0	-1000.0	-0.025	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1027.0	93.0	-0.134	0.046	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	10.0	696.0	65.0	-0.232	0.045	1000.0	-1000.0	-0.064	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	10.0	563.0	54.0	-0.208	0.047	1000.0	-1000.0	-0.024	-1000.0
Noncanonical Wnt signaling pathway	10.0	260.0	26.0	-0.139	0.032	1000.0	-1000.0	-0.031	-1000.0
Fc-epsilon receptor I signaling in mast cells	10.0	980.0	97.0	-0.244	0.036	1000.0	-1000.0	-0.047	-1000.0
Wnt signaling	10.0	74.0	7.0	-0.124	0.023	1000.0	-1000.0	0.001	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	506.0	52.0	-0.165	0.068	1000.0	-1000.0	-0.021	-1000.0
Integrins in angiogenesis	9.0	782.0	84.0	-0.1	0.064	1000.0	-1000.0	-0.035	-1000.0
PDGFR-beta signaling pathway	9.0	875.0	97.0	-0.099	0.045	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	150.0	17.0	-0.112	0.033	1000.0	-1000.0	-0.017	-1000.0
Arf6 signaling events	8.0	516.0	62.0	-0.221	0.069	1000.0	-1000.0	-0.021	-1000.0
Retinoic acid receptors-mediated signaling	8.0	474.0	58.0	-0.151	0.063	1000.0	-1000.0	-0.025	-1000.0
BCR signaling pathway	8.0	823.0	99.0	-0.162	0.058	1000.0	-1000.0	-0.055	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	994.0	120.0	-0.382	0.173	1000.0	-1000.0	-0.043	-1000.0
BARD1 signaling events	7.0	404.0	57.0	-0.053	0.063	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PTP1B	7.0	598.0	76.0	-0.21	0.049	1000.0	-1000.0	-0.026	-1000.0
BMP receptor signaling	7.0	644.0	81.0	-0.206	0.063	1000.0	-1000.0	-0.031	-1000.0
Glypican 1 network	7.0	368.0	48.0	-0.125	0.053	1000.0	-1000.0	-0.019	-1000.0
Regulation of Androgen receptor activity	7.0	539.0	70.0	-0.177	0.045	1000.0	-1000.0	-0.03	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	309.0	46.0	-0.651	0.036	1000.0	-1000.0	-0.03	-1000.0
Syndecan-4-mediated signaling events	6.0	422.0	67.0	-0.194	0.046	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	6.0	474.0	74.0	-0.32	0.075	1000.0	-1000.0	-0.032	-1000.0
Aurora B signaling	6.0	417.0	67.0	-0.463	0.07	1000.0	-1000.0	-0.035	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	753.0	136.0	-0.297	0.073	1000.0	-1000.0	-0.03	-1000.0
Syndecan-2-mediated signaling events	5.0	393.0	69.0	-0.194	0.048	1000.0	-1000.0	-0.018	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	26.0	5.0	-0.005	0.022	1000.0	-1000.0	0.014	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	340.0	61.0	-0.244	0.082	1000.0	-1000.0	-0.031	-1000.0
Nectin adhesion pathway	5.0	338.0	63.0	-0.064	0.08	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	5.0	258.0	47.0	-0.445	0.048	1000.0	-1000.0	-0.021	-1000.0
LPA receptor mediated events	5.0	610.0	102.0	-0.244	0.033	1000.0	-1000.0	-0.068	-1000.0
LPA4-mediated signaling events	4.0	56.0	12.0	-0.118	0.009	1000.0	-1000.0	-0.022	-1000.0
Syndecan-1-mediated signaling events	4.0	159.0	34.0	-0.132	0.032	1000.0	-1000.0	-0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	374.0	85.0	-0.389	0.069	1000.0	-1000.0	-0.036	-1000.0
IL2 signaling events mediated by PI3K	4.0	277.0	58.0	-0.195	0.054	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	4.0	367.0	86.0	-0.06	0.057	1000.0	-1000.0	-0.05	-1000.0
p75(NTR)-mediated signaling	3.0	496.0	125.0	-0.132	0.082	1000.0	-1000.0	-0.046	-1000.0
PLK1 signaling events	3.0	287.0	85.0	-0.036	0.052	1000.0	-1000.0	-0.038	-1000.0
Ceramide signaling pathway	3.0	233.0	76.0	-0.067	0.09	1000.0	-1000.0	-0.014	-1000.0
Regulation of p38-alpha and p38-beta	3.0	163.0	54.0	-0.052	0.075	1000.0	-1000.0	-0.041	-1000.0
Glypican 2 network	3.0	12.0	4.0	0.012	0.023	1000.0	-1000.0	0.016	-1000.0
IL27-mediated signaling events	3.0	174.0	51.0	-0.192	0.062	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by STAT5	3.0	68.0	22.0	-0.046	0.036	1000.0	-1000.0	-0.024	-1000.0
Caspase cascade in apoptosis	2.0	174.0	74.0	-0.072	0.079	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	2.0	196.0	69.0	-0.11	0.061	1000.0	-1000.0	-0.02	-1000.0
Cellular roles of Anthrax toxin	2.0	96.0	39.0	-0.103	0.044	1000.0	-1000.0	-0.019	-1000.0
Aurora C signaling	2.0	16.0	7.0	-0.008	0.028	1000.0	-1000.0	-0.011	-1000.0
mTOR signaling pathway	2.0	128.0	53.0	-0.016	0.043	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	95.0	37.0	-0.026	0.054	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	2.0	174.0	62.0	-0.049	0.077	1000.0	-1000.0	-0.022	-1000.0
ceramide signaling pathway	2.0	135.0	49.0	-0.02	0.047	1000.0	-1000.0	-0.02	-1000.0
HIF-2-alpha transcription factor network	2.0	107.0	43.0	-0.107	0.109	1000.0	-1000.0	-0.039	-1000.0
Ephrin B reverse signaling	2.0	133.0	48.0	-0.064	0.053	1000.0	-1000.0	-0.028	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	207.0	83.0	-0.102	0.063	1000.0	-1000.0	-0.015	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	88.0	36.0	-0.045	0.057	1000.0	-1000.0	-0.029	-1000.0
Atypical NF-kappaB pathway	2.0	70.0	31.0	-0.011	0.043	1000.0	-1000.0	-0.01	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	134.0	45.0	-0.038	0.086	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	2.0	147.0	51.0	-0.07	0.074	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	2.0	173.0	85.0	-0.13	0.076	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	265.0	125.0	-0.064	0.073	1000.0	-1000.0	-0.031	-1000.0
TCGA08_rtk_signaling	2.0	55.0	26.0	-0.158	0.045	1000.0	-1000.0	-0.011	-1000.0
Class I PI3K signaling events	2.0	164.0	73.0	-0.063	0.062	1000.0	-1000.0	-0.026	-1000.0
Regulation of Telomerase	2.0	210.0	102.0	-0.245	0.083	1000.0	-1000.0	-0.019	-1000.0
IGF1 pathway	2.0	152.0	57.0	-0.018	0.068	1000.0	-1000.0	-0.027	-1000.0
S1P3 pathway	2.0	91.0	42.0	-0.034	0.047	1000.0	-1000.0	-0.023	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	68.0	33.0	-0.035	0.081	1000.0	-1000.0	-0.026	-1000.0
Rapid glucocorticoid signaling	2.0	46.0	20.0	-0.009	0.033	1000.0	-1000.0	-0.0	-1000.0
Visual signal transduction: Rods	2.0	143.0	52.0	-0.177	0.079	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by PRL	2.0	96.0	34.0	-0.089	0.047	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	170.0	78.0	-0.036	0.071	1000.0	-1000.0	-0.044	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	42.0	23.0	-0.048	0.062	1000.0	-1000.0	-0.018	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	30.0	28.0	0.0	0.064	1000.0	-1000.0	-0.014	-1000.0
PLK2 and PLK4 events	1.0	3.0	3.0	0.016	-1000.0	1000.0	-1000.0	-0.007	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	118.0	65.0	-0.019	0.077	1000.0	-1000.0	-0.032	-1000.0
Aurora A signaling	1.0	73.0	60.0	-0.018	0.072	1000.0	-1000.0	-0.011	-1000.0
EPO signaling pathway	1.0	74.0	55.0	-0.008	0.086	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	1.0	129.0	104.0	-0.055	0.078	1000.0	-1000.0	-0.026	-1000.0
FoxO family signaling	1.0	88.0	64.0	-0.035	0.084	1000.0	-1000.0	-0.029	-1000.0
Effects of Botulinum toxin	1.0	40.0	26.0	-0.023	0.05	1000.0	-1000.0	-0.004	-1000.0
E-cadherin signaling in keratinocytes	1.0	46.0	43.0	-0.028	0.052	1000.0	-1000.0	-0.021	-1000.0
S1P4 pathway	1.0	30.0	25.0	-0.0	0.049	1000.0	-1000.0	-0.02	-1000.0
Canonical NF-kappaB pathway	0.0	26.0	39.0	-0.013	0.073	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	0.0	50.0	75.0	-0.049	0.088	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	0.0	1.0	38.0	-0.004	0.073	1000.0	-1000.0	-0.009	-1000.0
Circadian rhythm pathway	0.0	4.0	22.0	-0.012	0.068	1000.0	-1000.0	-0.024	-1000.0
Ephrin A  reverse signaling	0.0	2.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.0	-1000.0
Arf6 downstream pathway	0.0	18.0	43.0	-0.056	0.059	1000.0	-1000.0	-0.025	-1000.0
Insulin-mediated glucose transport	0.0	14.0	32.0	-0.0	0.06	1000.0	-1000.0	-0.024	-1000.0
IFN-gamma pathway	0.0	62.0	68.0	-0.001	0.084	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	27.0	68.0	-0.047	0.062	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class III	0.0	35.0	40.0	-0.054	0.055	1000.0	-1000.0	-0.028	-1000.0
TRAIL signaling pathway	0.0	33.0	48.0	-0.0	0.078	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	0.0	3.0	17.0	-0.034	0.039	1000.0	-1000.0	-0.011	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.008	0.028	1000.0	-1000.0	-0.007	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.009	0.032	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	0.0	26.0	35.0	-0.021	0.082	1000.0	-1000.0	-0.013	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	64.0	74.0	-0.061	0.076	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	34.0	76.0	-0.006	0.079	1000.0	-1000.0	-0.048	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	0.0	0.079	1000.0	-1000.0	-0.023	-1000.0
Arf6 trafficking events	0.0	67.0	71.0	-0.058	0.061	1000.0	-1000.0	-0.029	-1000.0
EGFR-dependent Endothelin signaling events	0.0	12.0	21.0	-0.009	0.077	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	0.0	35.0	56.0	-0.019	0.079	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.028	0.053	1000.0	-1000.0	0.015	-1000.0
p38 MAPK signaling pathway	0.0	15.0	44.0	-0.003	0.066	1000.0	-1000.0	-0.009	-1000.0
Arf1 pathway	0.0	9.0	54.0	-0.002	0.058	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.088	1000.0	-1000.0	-0.0	-1000.0
Total	832	53836	7203	-20.1324262858	-1991.4240966	131000	-131000	-3.33683262979	-131000