Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.055 0.176 -9999.0 0.0 -0.593 37.0 37.0 IHH -0.128 0.2 -9999.0 0.0 -0.394 187.0 187.0 SHH Np/Cholesterol/GAS1 -0.146 0.13 -9999.0 0.0 -0.234 345.0 345.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.145 0.129 0.233 345.0 -9999.0 0.0 345.0 SMO/beta Arrestin2 -0.052 0.155 -9999.0 0.0 -0.297 135.0 135.0 SMO -0.06 0.162 -9999.0 0.0 -0.317 136.0 136.0 AKT1 -0.018 0.096 -9999.0 0.0 -0.472 6.0 6.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.003 0.076 -9999.0 0.0 -0.409 18.0 18.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.06 0.16 -9999.0 0.0 -0.314 136.0 136.0 STIL -0.048 0.115 -9999.0 0.0 -0.34 33.0 33.0 DHH N/PTCH2 -0.023 0.105 -9999.0 0.0 -0.295 68.0 68.0 DHH N/PTCH1 -0.059 0.138 -9999.0 0.0 -0.352 52.0 52.0 PIK3CA 0.01 0.018 -9999.0 0.0 -0.409 1.0 1.0 DHH -0.023 0.113 -9999.0 0.0 -0.409 42.0 42.0 PTHLH -0.07 0.212 -9999.0 0.0 -0.648 37.0 37.0 determination of left/right symmetry -0.06 0.16 -9999.0 0.0 -0.314 136.0 136.0 PIK3R1 0.007 0.04 -9999.0 0.0 -0.409 5.0 5.0 skeletal system development -0.069 0.21 -9999.0 0.0 -0.642 37.0 37.0 IHH N/Hhip -0.079 0.132 -9999.0 0.0 -0.263 157.0 157.0 DHH N/Hhip -0.023 0.098 -9999.0 0.0 -0.263 75.0 75.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.06 0.16 -9999.0 0.0 -0.314 136.0 136.0 pancreas development -0.013 0.088 -9999.0 0.0 -0.343 35.0 35.0 HHAT 0.008 0.036 -9999.0 0.0 -0.409 4.0 4.0 PI3K 0.013 0.031 -9999.0 0.0 -0.28 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.257 0.202 -9999.0 0.0 -0.409 343.0 343.0 somite specification -0.06 0.16 -9999.0 0.0 -0.314 136.0 136.0 SHH Np/Cholesterol/PTCH1 -0.052 0.116 -9999.0 0.0 -0.357 27.0 27.0 SHH Np/Cholesterol/PTCH2 -0.017 0.08 -9999.0 0.0 -0.18 98.0 98.0 SHH Np/Cholesterol/Megalin -0.067 0.103 -9999.0 0.0 -0.235 64.0 64.0 SHH -0.015 0.082 -9999.0 0.0 -0.223 72.0 72.0 catabolic process -0.054 0.137 -9999.0 0.0 -0.259 151.0 151.0 SMO/Vitamin D3 -0.049 0.14 -9999.0 0.0 -0.401 27.0 27.0 SHH Np/Cholesterol/Hhip -0.017 0.075 -9999.0 0.0 -0.167 103.0 103.0 LRP2 -0.111 0.163 -9999.0 0.0 -0.33 192.0 192.0 receptor-mediated endocytosis -0.076 0.137 -9999.0 0.0 -0.324 79.0 79.0 SHH Np/Cholesterol/BOC -0.012 0.073 -9999.0 0.0 -0.174 87.0 87.0 SHH Np/Cholesterol/CDO -0.029 0.097 -9999.0 0.0 -0.202 117.0 117.0 mesenchymal cell differentiation 0.017 0.074 0.166 103.0 -9999.0 0.0 103.0 mol:Vitamin D3 -0.041 0.122 -9999.0 0.0 -0.353 28.0 28.0 IHH N/PTCH2 -0.079 0.138 -9999.0 0.0 -0.277 147.0 147.0 CDON -0.035 0.131 -9999.0 0.0 -0.409 59.0 59.0 IHH N/PTCH1 -0.035 0.149 -9999.0 0.0 -0.261 151.0 151.0 Megalin/LRPAP1 -0.068 0.112 -9999.0 0.0 -0.218 192.0 192.0 PTCH2 -0.012 0.096 -9999.0 0.0 -0.409 30.0 30.0 SHH Np/Cholesterol -0.012 0.061 -9999.0 0.0 -0.165 72.0 72.0 PTCH1 -0.054 0.137 -9999.0 0.0 -0.26 151.0 151.0 HHIP -0.013 0.088 -9999.0 0.0 -0.344 35.0 35.0