Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	183.0	9338.0	51.0	-0.97	0.011	1000.0	-1000.0	-0.136	-1000.0
Aurora B signaling	160.0	10732.0	67.0	-0.52	0.011	1000.0	-1000.0	-0.038	-1000.0
HIF-1-alpha transcription factor network	125.0	9515.0	76.0	-0.487	0.017	1000.0	-1000.0	-0.065	-1000.0
Signaling events regulated by Ret tyrosine kinase	120.0	9865.0	82.0	-0.187	0.011	1000.0	-1000.0	-0.047	-1000.0
Endothelins	107.0	10300.0	96.0	-0.337	0.011	1000.0	-1000.0	-0.046	-1000.0
Angiopoietin receptor Tie2-mediated signaling	105.0	9284.0	88.0	-0.316	0.043	1000.0	-1000.0	-0.074	-1000.0
p75(NTR)-mediated signaling	91.0	11418.0	125.0	-0.199	0.03	1000.0	-1000.0	-0.055	-1000.0
PDGFR-alpha signaling pathway	91.0	4047.0	44.0	-0.294	0.025	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by the Hedgehog family	89.0	4633.0	52.0	-0.257	0.145	1000.0	-1000.0	-0.018	-1000.0
Integrins in angiogenesis	80.0	6795.0	84.0	-0.288	0.024	1000.0	-1000.0	-0.05	-1000.0
Cellular roles of Anthrax toxin	70.0	2747.0	39.0	-0.127	0.019	1000.0	-1000.0	-0.013	-1000.0
S1P3 pathway	69.0	2909.0	42.0	-0.411	0.016	1000.0	-1000.0	-0.025	-1000.0
Aurora C signaling	68.0	478.0	7.0	-0.288	0.009	1000.0	-1000.0	-0.017	-1000.0
Nongenotropic Androgen signaling	68.0	3581.0	52.0	-0.216	0.106	1000.0	-1000.0	-0.032	-1000.0
Wnt signaling	61.0	427.0	7.0	-0.089	-0.002	1000.0	-1000.0	-0.014	-1000.0
PLK1 signaling events	57.0	4868.0	85.0	-0.296	0.044	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	57.0	2548.0	44.0	-0.08	0.011	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	56.0	3165.0	56.0	-0.154	0.03	1000.0	-1000.0	-0.043	-1000.0
Effects of Botulinum toxin	55.0	1450.0	26.0	-0.112	0.018	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	54.0	653.0	12.0	-0.123	0.015	1000.0	-1000.0	-0.007	-1000.0
Glypican 1 network	54.0	2626.0	48.0	-0.216	0.022	1000.0	-1000.0	-0.012	-1000.0
IGF1 pathway	50.0	2852.0	57.0	-0.076	0.022	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	49.0	2974.0	60.0	-0.253	0.022	1000.0	-1000.0	-0.017	-1000.0
Fc-epsilon receptor I signaling in mast cells	49.0	4802.0	97.0	-0.125	0.028	1000.0	-1000.0	-0.046	-1000.0
S1P4 pathway	49.0	1237.0	25.0	-0.1	0.024	1000.0	-1000.0	-0.013	-1000.0
S1P5 pathway	47.0	801.0	17.0	-0.1	0.032	1000.0	-1000.0	-0.013	-1000.0
Noncanonical Wnt signaling pathway	46.0	1197.0	26.0	-0.136	0.011	1000.0	-1000.0	-0.025	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	46.0	3159.0	68.0	-0.203	0.08	1000.0	-1000.0	-0.082	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	46.0	5574.0	120.0	-0.186	0.138	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	46.0	3646.0	78.0	-0.099	0.043	1000.0	-1000.0	-0.035	-1000.0
TCGA08_retinoblastoma	45.0	365.0	8.0	-0.135	0.024	1000.0	-1000.0	-0.009	-1000.0
Thromboxane A2 receptor signaling	44.0	4702.0	105.0	-0.176	0.031	1000.0	-1000.0	-0.039	-1000.0
BMP receptor signaling	42.0	3417.0	81.0	-0.278	0.038	1000.0	-1000.0	-0.041	-1000.0
Plasma membrane estrogen receptor signaling	42.0	3679.0	86.0	-0.152	0.066	1000.0	-1000.0	-0.042	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	41.0	1420.0	34.0	-0.039	0.011	1000.0	-1000.0	-0.014	-1000.0
Syndecan-1-mediated signaling events	41.0	1411.0	34.0	-0.174	0.011	1000.0	-1000.0	-0.02	-1000.0
amb2 Integrin signaling	41.0	3427.0	82.0	-0.148	0.022	1000.0	-1000.0	-0.045	-1000.0
Ephrin A  reverse signaling	38.0	267.0	7.0	-0.023	-0.0	1000.0	-1000.0	-0.01	-1000.0
FOXA2 and FOXA3 transcription factor networks	38.0	1764.0	46.0	-0.225	0.016	1000.0	-1000.0	-0.062	-1000.0
S1P1 pathway	38.0	1375.0	36.0	-0.123	0.011	1000.0	-1000.0	-0.031	-1000.0
Ras signaling in the CD4+ TCR pathway	38.0	658.0	17.0	-0.077	0.015	1000.0	-1000.0	-0.019	-1000.0
Osteopontin-mediated events	34.0	1314.0	38.0	-0.118	0.014	1000.0	-1000.0	-0.053	-1000.0
Ephrin B reverse signaling	33.0	1600.0	48.0	-0.095	0.015	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	32.0	228.0	7.0	-0.089	0.047	1000.0	-1000.0	-0.007	-1000.0
LPA receptor mediated events	31.0	3235.0	102.0	-0.142	0.029	1000.0	-1000.0	-0.055	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	30.0	2611.0	85.0	-0.21	0.012	1000.0	-1000.0	-0.034	-1000.0
Glypican 2 network	30.0	120.0	4.0	-0.014	-0.001	1000.0	-1000.0	-0.006	-1000.0
IL4-mediated signaling events	29.0	2727.0	91.0	-0.52	0.265	1000.0	-1000.0	-0.134	-1000.0
FAS signaling pathway (CD95)	29.0	1406.0	47.0	-0.075	0.037	1000.0	-1000.0	-0.025	-1000.0
EGFR-dependent Endothelin signaling events	29.0	616.0	21.0	-0.114	0.02	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	28.0	1747.0	62.0	-0.087	0.027	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Rods	28.0	1504.0	52.0	-0.11	0.011	1000.0	-1000.0	-0.046	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	27.0	1490.0	54.0	-0.144	0.022	1000.0	-1000.0	-0.05	-1000.0
Syndecan-4-mediated signaling events	27.0	1826.0	67.0	-0.255	0.016	1000.0	-1000.0	-0.051	-1000.0
Visual signal transduction: Cones	26.0	994.0	38.0	-0.081	0.011	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	26.0	1379.0	52.0	-0.079	0.023	1000.0	-1000.0	-0.034	-1000.0
Coregulation of Androgen receptor activity	25.0	1964.0	76.0	-0.132	0.022	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	24.0	3019.0	125.0	-0.067	0.029	1000.0	-1000.0	-0.054	-1000.0
Hedgehog signaling events mediated by Gli proteins	23.0	1539.0	65.0	-0.1	0.038	1000.0	-1000.0	-0.037	-1000.0
Syndecan-2-mediated signaling events	22.0	1532.0	69.0	-0.105	0.028	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1346.0	61.0	-0.118	0.031	1000.0	-1000.0	-0.043	-1000.0
Glucocorticoid receptor regulatory network	22.0	2513.0	114.0	-0.239	0.046	1000.0	-1000.0	-0.046	-1000.0
Calcium signaling in the CD4+ TCR pathway	22.0	708.0	31.0	-0.118	0.015	1000.0	-1000.0	-0.047	-1000.0
TCGA08_rtk_signaling	22.0	594.0	26.0	-0.147	0.023	1000.0	-1000.0	-0.011	-1000.0
IL2 signaling events mediated by STAT5	22.0	488.0	22.0	-0.103	0.056	1000.0	-1000.0	-0.028	-1000.0
BCR signaling pathway	22.0	2205.0	99.0	-0.06	0.047	1000.0	-1000.0	-0.047	-1000.0
Insulin Pathway	21.0	1557.0	74.0	-0.132	0.03	1000.0	-1000.0	-0.049	-1000.0
Regulation of Androgen receptor activity	21.0	1536.0	70.0	-0.218	0.023	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	20.0	1553.0	75.0	-0.118	0.062	1000.0	-1000.0	-0.043	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	665.0	33.0	-0.156	0.034	1000.0	-1000.0	-0.025	-1000.0
Retinoic acid receptors-mediated signaling	19.0	1105.0	58.0	-0.052	0.022	1000.0	-1000.0	-0.043	-1000.0
Regulation of nuclear SMAD2/3 signaling	18.0	2472.0	136.0	-0.156	0.054	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by PTP1B	18.0	1390.0	76.0	-0.115	0.024	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	18.0	1180.0	63.0	-0.067	0.021	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	18.0	932.0	51.0	-0.097	0.05	1000.0	-1000.0	-0.031	-1000.0
Regulation of p38-alpha and p38-beta	18.0	993.0	54.0	-0.176	0.043	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	18.0	374.0	20.0	-0.051	0.011	1000.0	-1000.0	-0.007	-1000.0
Sphingosine 1-phosphate (S1P) pathway	17.0	501.0	28.0	-0.1	0.032	1000.0	-1000.0	-0.017	-1000.0
BARD1 signaling events	16.0	967.0	57.0	-0.127	0.028	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	16.0	1138.0	68.0	-0.239	0.04	1000.0	-1000.0	-0.021	-1000.0
Signaling mediated by p38-gamma and p38-delta	16.0	240.0	15.0	-0.017	0.021	1000.0	-1000.0	-0.014	-1000.0
Regulation of Telomerase	16.0	1664.0	102.0	-0.301	0.038	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	15.0	1314.0	87.0	-0.301	0.045	1000.0	-1000.0	-0.094	-1000.0
IL1-mediated signaling events	14.0	900.0	62.0	-0.038	0.04	1000.0	-1000.0	-0.05	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1338.0	93.0	-0.044	0.04	1000.0	-1000.0	-0.046	-1000.0
EPHB forward signaling	14.0	1264.0	85.0	-0.034	0.03	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by PRL	14.0	479.0	34.0	-0.127	0.018	1000.0	-1000.0	-0.015	-1000.0
IFN-gamma pathway	13.0	923.0	68.0	-0.226	0.048	1000.0	-1000.0	-0.051	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1127.0	83.0	-0.239	0.044	1000.0	-1000.0	-0.043	-1000.0
FoxO family signaling	13.0	884.0	64.0	-0.239	0.042	1000.0	-1000.0	-0.045	-1000.0
ErbB4 signaling events	12.0	838.0	69.0	-0.072	0.03	1000.0	-1000.0	-0.056	-1000.0
Insulin-mediated glucose transport	12.0	407.0	32.0	-0.239	0.025	1000.0	-1000.0	-0.03	-1000.0
Syndecan-3-mediated signaling events	12.0	427.0	35.0	-0.089	0.03	1000.0	-1000.0	-0.023	-1000.0
PDGFR-beta signaling pathway	12.0	1256.0	97.0	-0.021	0.039	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	11.0	612.0	55.0	-0.025	0.035	1000.0	-1000.0	-0.045	-1000.0
mTOR signaling pathway	11.0	627.0	53.0	-0.026	0.018	1000.0	-1000.0	-0.036	-1000.0
HIF-2-alpha transcription factor network	11.0	498.0	43.0	-0.142	0.022	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by PI3K	11.0	681.0	58.0	-0.113	0.043	1000.0	-1000.0	-0.053	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.007	-1000.0
ErbB2/ErbB3 signaling events	10.0	672.0	65.0	-0.12	0.022	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class III	10.0	407.0	40.0	-0.078	0.016	1000.0	-1000.0	-0.021	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	166.0	17.0	-0.014	0.034	1000.0	-1000.0	-0.019	-1000.0
Ceramide signaling pathway	8.0	615.0	76.0	-0.068	0.036	1000.0	-1000.0	-0.023	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	328.0	37.0	-0.02	0.027	1000.0	-1000.0	-0.026	-1000.0
ceramide signaling pathway	8.0	403.0	49.0	-0.031	0.038	1000.0	-1000.0	-0.016	-1000.0
IL27-mediated signaling events	8.0	409.0	51.0	-0.053	0.014	1000.0	-1000.0	-0.059	-1000.0
Caspase cascade in apoptosis	7.0	543.0	74.0	-0.032	0.035	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class II	7.0	533.0	75.0	-0.051	0.029	1000.0	-1000.0	-0.025	-1000.0
IL23-mediated signaling events	7.0	444.0	60.0	-0.047	0.043	1000.0	-1000.0	-0.116	-1000.0
p38 MAPK signaling pathway	7.0	324.0	44.0	-0.046	0.028	1000.0	-1000.0	-0.036	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	270.0	45.0	-0.032	0.057	1000.0	-1000.0	-0.048	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	373.0	74.0	-0.075	0.062	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	4.0	176.0	39.0	-0.032	0.058	1000.0	-1000.0	-0.048	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	0.008	0.015	1000.0	-1000.0	-0.008	-1000.0
TRAIL signaling pathway	4.0	198.0	48.0	-0.001	0.037	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events	4.0	316.0	73.0	-0.015	0.053	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	4.0	351.0	71.0	-0.193	0.035	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	3.0	377.0	104.0	-0.032	0.044	1000.0	-1000.0	-0.034	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	143.0	36.0	-0.031	0.032	1000.0	-1000.0	-0.039	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	2.0	46.0	23.0	-0.004	0.036	1000.0	-1000.0	-0.018	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	11.0	5.0	0.009	0.015	1000.0	-1000.0	-0.008	-1000.0
VEGFR1 specific signals	2.0	138.0	56.0	-0.062	0.052	1000.0	-1000.0	-0.025	-1000.0
Arf6 downstream pathway	1.0	50.0	43.0	-0.023	0.023	1000.0	-1000.0	-0.021	-1000.0
Atypical NF-kappaB pathway	1.0	36.0	31.0	-0.0	0.04	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	95.0	76.0	-0.003	0.048	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	1.0	80.0	43.0	-0.034	0.037	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	1.0	7.0	5.0	0.009	0.021	1000.0	-1000.0	-0.011	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.011	0.04	1000.0	-1000.0	-0.025	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.028	1000.0	-1000.0	-0.032	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.0	0.028	1000.0	-1000.0	-0.018	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	0.0	0.033	1000.0	-1000.0	-0.013	-1000.0
Total	4001	238234	7203	-17.2989568793	4.34967422178	131000	-131000	-4.74454681249	-131000