E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.015 0.092 -9999.0 0.0 -0.272 58.0 58.0 KLHL20 -0.005 0.062 0.199 2.0 -0.201 29.0 31.0 CYFIP2 0.021 0.028 -9999.0 0.0 -0.349 3.0 3.0 Rac1/GDP 0.001 0.069 0.247 3.0 -0.252 9.0 12.0 ENAH -0.019 0.093 -9999.0 0.0 -0.275 59.0 59.0 AP1M1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.028 -9999.0 0.0 -0.189 2.0 2.0 ABI1/Sra1/Nap1 -0.013 0.038 -9999.0 0.0 -0.138 30.0 30.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.028 0.208 1.0 -0.19 2.0 3.0 RAPGEF1 -0.012 0.08 0.224 2.0 -0.255 38.0 40.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.012 0.101 -9999.0 0.0 -0.28 64.0 64.0 CRK -0.009 0.083 -9999.0 0.0 -0.268 42.0 42.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.027 -9999.0 0.0 -0.286 2.0 2.0 alphaE/beta7 Integrin 0.032 0.013 0.208 1.0 -9999.0 0.0 1.0 IQGAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.013 0.087 -9999.0 0.0 -0.275 51.0 51.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.016 -9999.0 0.0 -0.145 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.036 -9999.0 0.0 -0.185 12.0 12.0 PI3K -0.019 0.02 -9999.0 0.0 -0.184 2.0 2.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.027 -9999.0 0.0 -0.344 2.0 2.0 TIAM1 0.013 0.058 -9999.0 0.0 -0.349 13.0 13.0 E-cadherin(dimer)/Ca2+ 0.046 0.024 -9999.0 0.0 -0.169 2.0 2.0 AKT1 -0.012 0.021 -9999.0 0.0 -0.126 1.0 1.0 PIK3R1 0.018 0.036 -9999.0 0.0 -0.349 5.0 5.0 CDH1 0.019 0.024 -9999.0 0.0 -0.349 2.0 2.0 RhoA/GDP 0.001 0.068 0.231 1.0 -0.253 7.0 8.0 actin cytoskeleton organization -0.003 0.048 0.172 3.0 -0.148 28.0 31.0 CDC42/GDP 0.003 0.069 0.247 3.0 -0.252 9.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.022 -9999.0 0.0 -0.325 2.0 2.0 ITGB7 0.023 0.012 0.279 1.0 -9999.0 0.0 1.0 RAC1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.026 -9999.0 0.0 -0.181 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.019 -9999.0 0.0 -0.165 2.0 2.0 mol:GDP -0.011 0.074 0.254 3.0 -0.286 10.0 13.0 CDC42/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.017 -9999.0 0.0 -0.349 1.0 1.0 p120 catenin/RhoA/GDP 0.008 0.07 0.235 1.0 -0.267 5.0 6.0 RAC1/GTP/IQGAP1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.004 0.037 0.155 6.0 -0.102 10.0 16.0 NME1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.084 -9999.0 0.0 -0.272 48.0 48.0 regulation of cell-cell adhesion 0.008 0.023 -9999.0 0.0 -0.168 2.0 2.0 WASF2 -0.001 0.025 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.017 0.039 -9999.0 0.0 -0.207 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.034 -9999.0 0.0 -0.251 2.0 2.0 CCND1 0.004 0.043 0.176 6.0 -0.123 12.0 18.0 VAV2 -0.03 0.165 -9999.0 0.0 -0.57 34.0 34.0 RAP1/GDP 0.018 0.06 0.251 4.0 -0.243 5.0 9.0 adherens junction assembly -0.011 0.084 -9999.0 0.0 -0.265 50.0 50.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.041 0.029 -9999.0 0.0 -0.244 2.0 2.0 E-cadherin/beta catenin 0.008 0.019 -9999.0 0.0 -0.29 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.016 0.093 -9999.0 0.0 -0.275 58.0 58.0 PIK3CA 0.02 0.018 -9999.0 0.0 -0.349 1.0 1.0 Rac1/GTP -0.018 0.086 0.181 1.0 -0.31 31.0 32.0 E-cadherin/beta catenin/alpha catenin 0.039 0.022 -9999.0 0.0 -0.197 2.0 2.0 ITGAE 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.013 0.102 -9999.0 0.0 -0.285 64.0 64.0