Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.003 0.089 0.254 51.0 -0.214 11.0 62.0 KIRREL -0.017 0.113 -9999.0 0.0 -0.355 53.0 53.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.003 0.09 0.215 11.0 -0.255 51.0 62.0 PLCG1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.023 0.078 0.31 2.0 -0.189 50.0 52.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.006 0.07 0.209 2.0 -0.206 49.0 51.0 FYN 0.016 0.115 0.228 97.0 -0.183 50.0 147.0 mol:Ca2+ 0.02 0.075 0.337 1.0 -0.188 50.0 51.0 mol:DAG 0.021 0.075 0.343 1.0 -0.188 50.0 51.0 NPHS2 -0.008 0.033 0.297 3.0 -9999.0 0.0 3.0 mol:IP3 0.021 0.075 0.343 1.0 -0.188 50.0 51.0 regulation of endocytosis 0.015 0.067 0.193 7.0 -0.173 50.0 57.0 Nephrin/NEPH1/podocin/Cholesterol 0.013 0.073 0.204 12.0 -0.185 51.0 63.0 establishment of cell polarity 0.003 0.089 0.214 11.0 -0.254 51.0 62.0 Nephrin/NEPH1/podocin/NCK1-2 0.029 0.08 0.309 2.0 -0.183 50.0 52.0 Nephrin/NEPH1/beta Arrestin2 0.016 0.069 0.198 8.0 -0.175 50.0 58.0 NPHS1 0.02 0.053 0.289 13.0 -9999.0 0.0 13.0 Nephrin/NEPH1/podocin 0.014 0.072 0.202 11.0 -0.184 50.0 61.0 TJP1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.023 -9999.0 0.0 -0.349 2.0 2.0 NCK2 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.021 0.076 0.348 1.0 -0.189 50.0 51.0 CD2AP 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.021 0.076 0.348 1.0 -0.188 50.0 51.0 GRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.125 0.234 91.0 -0.201 66.0 157.0 cytoskeleton organization -0.016 0.079 0.218 18.0 -0.218 48.0 66.0 Nephrin/NEPH1 0.007 0.063 0.176 11.0 -0.17 51.0 62.0 Nephrin/NEPH1/ZO-1 0.014 0.077 0.203 11.0 -0.201 51.0 62.0