Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.155 -9999.0 0.0 -0.536 31.0 31.0 IHH -0.041 0.21 0.309 57.0 -0.387 121.0 178.0 SHH Np/Cholesterol/GAS1 -0.083 0.102 0.23 1.0 -0.186 259.0 260.0 LRPAP1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.083 0.102 0.185 259.0 -0.227 1.0 260.0 SMO/beta Arrestin2 -0.039 0.158 -9999.0 0.0 -0.414 27.0 27.0 SMO -0.056 0.154 -9999.0 0.0 -0.325 110.0 110.0 AKT1 -0.019 0.124 -9999.0 0.0 -0.472 22.0 22.0 ARRB2 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.011 0.066 -9999.0 0.0 -0.349 17.0 17.0 ADRBK1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.055 0.153 -9999.0 0.0 -0.322 109.0 109.0 STIL -0.011 0.118 0.217 13.0 -0.28 27.0 40.0 DHH N/PTCH2 -0.004 0.098 -9999.0 0.0 -0.257 67.0 67.0 DHH N/PTCH1 -0.043 0.132 -9999.0 0.0 -0.341 40.0 40.0 PIK3CA 0.02 0.018 -9999.0 0.0 -0.349 1.0 1.0 DHH -0.007 0.1 -9999.0 0.0 -0.349 42.0 42.0 PTHLH -0.062 0.19 -9999.0 0.0 -0.592 31.0 31.0 determination of left/right symmetry -0.055 0.153 -9999.0 0.0 -0.322 109.0 109.0 PIK3R1 0.018 0.036 -9999.0 0.0 -0.349 5.0 5.0 skeletal system development -0.061 0.188 -9999.0 0.0 -0.587 31.0 31.0 IHH N/Hhip -0.004 0.142 0.219 72.0 -0.229 121.0 193.0 DHH N/Hhip 0.016 0.089 0.208 26.0 -0.243 47.0 73.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.055 0.153 -9999.0 0.0 -0.322 109.0 109.0 pancreas development 0.032 0.068 0.278 28.0 -0.348 5.0 33.0 HHAT 0.017 0.033 -9999.0 0.0 -0.349 4.0 4.0 PI3K 0.026 0.029 -9999.0 0.0 -0.245 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.201 0.181 -9999.0 0.0 -0.349 318.0 318.0 somite specification -0.055 0.153 -9999.0 0.0 -0.322 109.0 109.0 SHH Np/Cholesterol/PTCH1 -0.022 0.109 0.241 5.0 -0.285 29.0 34.0 SHH Np/Cholesterol/PTCH2 0.015 0.059 0.224 6.0 -0.197 28.0 34.0 SHH Np/Cholesterol/Megalin 0.079 0.095 0.204 172.0 -0.176 6.0 178.0 SHH 0.004 0.058 0.13 63.0 -0.245 6.0 69.0 catabolic process -0.037 0.126 -9999.0 0.0 -0.251 127.0 127.0 SMO/Vitamin D3 -0.015 0.149 0.301 8.0 -0.336 27.0 35.0 SHH Np/Cholesterol/Hhip 0.03 0.059 0.205 33.0 -0.184 11.0 44.0 LRP2 0.111 0.122 0.279 183.0 -9999.0 0.0 183.0 receptor-mediated endocytosis -0.009 0.139 0.232 11.0 -0.333 27.0 38.0 SHH Np/Cholesterol/BOC 0.017 0.054 0.224 6.0 -0.192 22.0 28.0 SHH Np/Cholesterol/CDO 0.006 0.069 0.224 6.0 -0.189 47.0 53.0 mesenchymal cell differentiation -0.03 0.059 0.183 11.0 -0.203 33.0 44.0 mol:Vitamin D3 -0.001 0.134 0.292 16.0 -0.29 28.0 44.0 IHH N/PTCH2 -0.022 0.147 0.199 56.0 -0.249 134.0 190.0 CDON -0.015 0.11 -9999.0 0.0 -0.349 52.0 52.0 IHH N/PTCH1 -0.026 0.146 -9999.0 0.0 -0.253 127.0 127.0 Megalin/LRPAP1 0.09 0.084 0.208 176.0 -9999.0 0.0 176.0 PTCH2 0.002 0.085 -9999.0 0.0 -0.349 29.0 29.0 SHH Np/Cholesterol 0.008 0.022 -9999.0 0.0 -0.183 6.0 6.0 PTCH1 -0.037 0.127 -9999.0 0.0 -0.252 127.0 127.0 HHIP 0.032 0.069 0.279 28.0 -0.349 5.0 33.0