Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.025 -9999.0 0.0 -0.18 8.0 8.0 epithelial cell differentiation 0.041 0.022 -9999.0 0.0 -0.168 2.0 2.0 CYFIP2 0.021 0.028 -9999.0 0.0 -0.349 3.0 3.0 ENAH -0.006 0.057 0.259 13.0 -9999.0 0.0 13.0 EGFR 0.014 0.059 0.327 1.0 -0.349 13.0 14.0 EPHA2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.012 0.024 0.173 6.0 -0.172 1.0 7.0 CTNNB1 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.017 -9999.0 0.0 -0.207 1.0 1.0 AQP5 0.077 0.088 0.264 3.0 -0.345 9.0 12.0 CTNND1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.017 0.169 2.0 -0.17 1.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.036 0.17 6.0 -0.181 14.0 20.0 EGF 0.031 0.052 0.279 20.0 -0.349 1.0 21.0 NCKAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.001 0.057 -9999.0 0.0 -0.304 15.0 15.0 cortical microtubule organization 0.041 0.022 -9999.0 0.0 -0.168 2.0 2.0 GO:0000145 -0.013 0.016 0.158 2.0 -0.162 1.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.024 -9999.0 0.0 -0.169 2.0 2.0 MLLT4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.02 0.018 -9999.0 0.0 -0.165 3.0 3.0 ARF6 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.031 0.207 1.0 -0.19 2.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.016 0.164 3.0 -9999.0 0.0 3.0 PVRL2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.023 0.171 5.0 -0.172 1.0 6.0 ARF6/GTP 0.047 0.033 -9999.0 0.0 -0.179 2.0 2.0 CDH1 0.019 0.024 -9999.0 0.0 -0.349 2.0 2.0 EGFR/EGFR/EGF/EGF 0.033 0.043 -9999.0 0.0 -0.179 13.0 13.0 RhoA/GDP 0.042 0.023 -9999.0 0.0 -0.162 2.0 2.0 actin cytoskeleton organization -0.014 0.02 0.159 5.0 -0.174 1.0 6.0 IGF-1R heterotetramer 0.009 0.069 -9999.0 0.0 -0.348 19.0 19.0 GIT1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.069 -9999.0 0.0 -0.349 19.0 19.0 IGF1 -0.047 0.146 -9999.0 0.0 -0.349 100.0 100.0 DIAPH1 0.018 0.097 -9999.0 0.0 -0.529 7.0 7.0 Wnt receptor signaling pathway -0.041 0.022 0.168 2.0 -9999.0 0.0 2.0 RHOA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.02 0.018 -9999.0 0.0 -0.165 3.0 3.0 CTNNA1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.021 0.16 5.0 -0.177 1.0 6.0 EFNA1 0.02 0.02 0.303 2.0 -9999.0 0.0 2.0 LPP -0.014 0.022 0.167 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 0.03 0.025 -9999.0 0.0 -0.162 2.0 2.0 SEC6/SEC8 -0.02 0.012 -9999.0 0.0 -0.152 1.0 1.0 MGAT3 -0.016 0.036 0.172 6.0 -0.183 14.0 20.0 HGF/MET -0.003 0.087 -9999.0 0.0 -0.172 102.0 102.0 HGF -0.049 0.146 -9999.0 0.0 -0.349 102.0 102.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.025 -9999.0 0.0 -0.181 8.0 8.0 actin cable formation 0.046 0.105 0.306 33.0 -0.244 2.0 35.0 KIAA1543 -0.013 0.022 0.162 5.0 -0.165 2.0 7.0 KIFC3 -0.013 0.022 0.171 5.0 -0.172 1.0 6.0 NCK1 0.021 0.023 -9999.0 0.0 -0.349 2.0 2.0 EXOC3 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.024 0.173 6.0 -0.172 1.0 7.0 NCK1/GIT1 0.03 0.02 -9999.0 0.0 -0.245 2.0 2.0 mol:GDP 0.041 0.022 -9999.0 0.0 -0.168 2.0 2.0 EXOC4 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.012 0.024 0.172 6.0 -0.172 1.0 7.0 PIP5K1C -0.014 0.017 0.171 2.0 -0.172 1.0 3.0 LIMA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.018 0.086 0.295 19.0 -9999.0 0.0 19.0 adherens junction assembly -0.044 0.141 0.205 1.0 -0.564 30.0 31.0 IGF-1R heterotetramer/IGF1 -0.007 0.093 -9999.0 0.0 -0.183 107.0 107.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.039 0.279 4.0 -0.349 4.0 8.0 PLEKHA7 -0.013 0.023 0.172 5.0 -0.173 2.0 7.0 mol:GTP 0.042 0.03 -9999.0 0.0 -0.189 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.001 0.076 0.354 12.0 -9999.0 0.0 12.0 cortical actin cytoskeleton stabilization 0.013 0.025 -9999.0 0.0 -0.18 8.0 8.0 regulation of cell-cell adhesion -0.014 0.02 0.159 5.0 -0.174 1.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.025 -9999.0 0.0 -0.181 8.0 8.0