Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.093 0.168 -9999.0 0.0 -0.527 5.0 5.0 IHH -0.144 0.187 -9999.0 0.0 -0.364 21.0 21.0 SHH Np/Cholesterol/GAS1 -0.04 0.087 -9999.0 0.0 -0.181 14.0 14.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.086 0.18 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.106 0.182 -9999.0 0.0 -0.347 13.0 13.0 SMO -0.115 0.179 -9999.0 0.0 -0.357 14.0 14.0 AKT1 -0.069 0.164 -9999.0 0.0 -0.504 5.0 5.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 STIL -0.069 0.142 0.191 2.0 -0.304 9.0 11.0 DHH N/PTCH2 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.07 0.132 -9999.0 0.0 -0.221 21.0 21.0 PIK3CA 0.019 0.051 -9999.0 0.0 -0.346 1.0 1.0 DHH 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.129 0.209 -9999.0 0.0 -0.553 6.0 6.0 determination of left/right symmetry -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 PIK3R1 -0.007 0.099 -9999.0 0.0 -0.346 4.0 4.0 skeletal system development -0.129 0.207 -9999.0 0.0 -0.548 6.0 6.0 IHH N/Hhip -0.107 0.14 -9999.0 0.0 -0.258 22.0 22.0 DHH N/Hhip -0.0 0.09 -9999.0 0.0 -0.241 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 pancreas development -0.024 0.118 -9999.0 0.0 -0.346 6.0 6.0 HHAT -0.026 0.125 -9999.0 0.0 -0.346 7.0 7.0 PI3K 0.013 0.084 -9999.0 0.0 -0.307 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.048 0.138 -9999.0 0.0 -0.346 9.0 9.0 somite specification -0.113 0.177 -9999.0 0.0 -0.352 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.081 0.135 -9999.0 0.0 -0.276 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.005 0.069 -9999.0 0.0 -0.179 7.0 7.0 SHH Np/Cholesterol/Megalin -0.009 0.069 -9999.0 0.0 -0.182 7.0 7.0 SHH -0.018 0.08 -9999.0 0.0 -0.241 6.0 6.0 catabolic process -0.083 0.137 -9999.0 0.0 -0.25 20.0 20.0 SMO/Vitamin D3 -0.076 0.173 -9999.0 0.0 -0.305 16.0 16.0 SHH Np/Cholesterol/Hhip -0.03 0.089 -9999.0 0.0 -0.194 11.0 11.0 LRP2 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.081 0.169 -9999.0 0.0 -0.406 7.0 7.0 SHH Np/Cholesterol/BOC -0.005 0.065 -9999.0 0.0 -0.182 6.0 6.0 SHH Np/Cholesterol/CDO -0.008 0.07 -9999.0 0.0 -0.182 7.0 7.0 mesenchymal cell differentiation 0.029 0.088 0.193 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.066 0.155 0.211 2.0 -0.286 12.0 14.0 IHH N/PTCH2 -0.068 0.114 -9999.0 0.0 -0.22 18.0 18.0 CDON 0.023 0.019 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.09 0.141 -9999.0 0.0 -0.248 22.0 22.0 Megalin/LRPAP1 0.033 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.065 -9999.0 0.0 -0.177 7.0 7.0 PTCH1 -0.083 0.138 -9999.0 0.0 -0.251 20.0 20.0 HHIP -0.024 0.118 -9999.0 0.0 -0.346 6.0 6.0