Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	8.0	442.0	52.0	-0.144	0.04	1000.0	-1000.0	-0.018	-1000.0
Ephrin B reverse signaling	8.0	410.0	48.0	-0.222	0.028	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	7.0	573.0	76.0	-0.203	0.031	1000.0	-1000.0	-0.017	-1000.0
FOXM1 transcription factor network	7.0	364.0	51.0	-0.442	0.027	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	586.0	78.0	-0.233	0.089	1000.0	-1000.0	-0.038	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	-0.048	0.02	1000.0	-1000.0	-0.001	-1000.0
Osteopontin-mediated events	6.0	231.0	38.0	-0.096	0.028	1000.0	-1000.0	-0.013	-1000.0
IGF1 pathway	6.0	359.0	57.0	-0.064	0.046	1000.0	-1000.0	-0.02	-1000.0
Plasma membrane estrogen receptor signaling	6.0	522.0	86.0	-0.165	0.155	1000.0	-1000.0	-0.032	-1000.0
Noncanonical Wnt signaling pathway	5.0	147.0	26.0	-0.078	0.027	1000.0	-1000.0	-0.028	-1000.0
Glypican 1 network	5.0	278.0	48.0	-0.057	0.03	1000.0	-1000.0	-0.019	-1000.0
Nectin adhesion pathway	5.0	357.0	63.0	-0.084	0.055	1000.0	-1000.0	-0.023	-1000.0
Endothelins	5.0	535.0	96.0	-0.155	0.032	1000.0	-1000.0	-0.036	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	367.0	68.0	-0.211	0.118	1000.0	-1000.0	-0.066	-1000.0
TCGA08_retinoblastoma	5.0	47.0	8.0	-0.037	0.024	1000.0	-1000.0	-0.006	-1000.0
IL12-mediated signaling events	4.0	388.0	87.0	-0.262	0.051	1000.0	-1000.0	-0.051	-1000.0
Syndecan-1-mediated signaling events	4.0	148.0	34.0	-0.08	0.038	1000.0	-1000.0	-0.014	-1000.0
IL4-mediated signaling events	4.0	387.0	91.0	-0.557	0.359	1000.0	-1000.0	-0.103	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	182.0	44.0	-0.068	0.028	1000.0	-1000.0	-0.011	-1000.0
EPHB forward signaling	4.0	364.0	85.0	-0.057	0.046	1000.0	-1000.0	-0.042	-1000.0
Wnt signaling	4.0	33.0	7.0	-0.073	0.024	1000.0	-1000.0	-0.006	-1000.0
IL23-mediated signaling events	4.0	274.0	60.0	-0.312	0.028	1000.0	-1000.0	-0.065	-1000.0
Caspase cascade in apoptosis	3.0	236.0	74.0	-0.039	0.035	1000.0	-1000.0	-0.022	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	468.0	136.0	-0.414	0.083	1000.0	-1000.0	-0.022	-1000.0
Thromboxane A2 receptor signaling	3.0	338.0	105.0	-0.078	0.051	1000.0	-1000.0	-0.028	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	150.0	46.0	-0.171	0.033	1000.0	-1000.0	-0.055	-1000.0
BMP receptor signaling	3.0	248.0	81.0	-0.103	0.047	1000.0	-1000.0	-0.017	-1000.0
Reelin signaling pathway	3.0	181.0	56.0	-0.045	0.05	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	3.0	21.0	7.0	-0.036	0.023	1000.0	-1000.0	-0.004	-1000.0
FAS signaling pathway (CD95)	3.0	177.0	47.0	-0.085	0.034	1000.0	-1000.0	-0.032	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.011	-0.0	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	3.0	187.0	52.0	-0.1	0.049	1000.0	-1000.0	-0.018	-1000.0
IL27-mediated signaling events	3.0	162.0	51.0	-0.095	0.047	1000.0	-1000.0	-0.036	-1000.0
LPA receptor mediated events	3.0	337.0	102.0	-0.105	0.028	1000.0	-1000.0	-0.05	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	233.0	74.0	-0.057	0.05	1000.0	-1000.0	-0.046	-1000.0
Syndecan-4-mediated signaling events	3.0	219.0	67.0	-0.062	0.039	1000.0	-1000.0	-0.024	-1000.0
VEGFR1 specific signals	3.0	188.0	56.0	-0.047	0.028	1000.0	-1000.0	-0.024	-1000.0
Regulation of Androgen receptor activity	3.0	211.0	70.0	-0.144	0.034	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	2.0	205.0	76.0	-0.135	0.046	1000.0	-1000.0	-0.013	-1000.0
Visual signal transduction: Cones	2.0	81.0	38.0	-0.014	0.043	1000.0	-1000.0	-0.0	-1000.0
Syndecan-2-mediated signaling events	2.0	147.0	69.0	-0.036	0.041	1000.0	-1000.0	-0.029	-1000.0
Cellular roles of Anthrax toxin	2.0	107.0	39.0	-0.057	0.027	1000.0	-1000.0	-0.019	-1000.0
Arf6 signaling events	2.0	131.0	62.0	-0.01	0.043	1000.0	-1000.0	-0.001	-1000.0
Signaling events mediated by PTP1B	2.0	171.0	76.0	-0.071	0.047	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	188.0	65.0	-0.318	0.066	1000.0	-1000.0	-0.023	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	147.0	61.0	-0.085	0.051	1000.0	-1000.0	-0.024	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	261.0	97.0	-0.063	0.046	1000.0	-1000.0	-0.036	-1000.0
PLK1 signaling events	2.0	214.0	85.0	-0.044	0.029	1000.0	-1000.0	-0.013	-1000.0
PDGFR-alpha signaling pathway	2.0	114.0	44.0	-0.132	0.038	1000.0	-1000.0	-0.034	-1000.0
mTOR signaling pathway	2.0	115.0	53.0	-0.019	0.034	1000.0	-1000.0	-0.024	-1000.0
IFN-gamma pathway	2.0	183.0	68.0	-0.05	0.038	1000.0	-1000.0	-0.029	-1000.0
Glucocorticoid receptor regulatory network	2.0	237.0	114.0	-0.134	0.071	1000.0	-1000.0	-0.035	-1000.0
TRAIL signaling pathway	2.0	104.0	48.0	-0.014	0.037	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	2.0	157.0	62.0	-0.042	0.044	1000.0	-1000.0	-0.023	-1000.0
ceramide signaling pathway	2.0	127.0	49.0	-0.026	0.04	1000.0	-1000.0	-0.026	-1000.0
HIF-2-alpha transcription factor network	2.0	119.0	43.0	-0.05	0.049	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	2.0	93.0	36.0	-0.101	0.026	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	37.0	15.0	-0.026	0.026	1000.0	-1000.0	-0.023	-1000.0
Retinoic acid receptors-mediated signaling	2.0	161.0	58.0	-0.106	0.055	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	2.0	72.0	35.0	-0.057	0.051	1000.0	-1000.0	-0.01	-1000.0
IL2 signaling events mediated by PI3K	2.0	122.0	58.0	-0.101	0.028	1000.0	-1000.0	-0.03	-1000.0
Integrins in angiogenesis	2.0	249.0	84.0	-0.075	0.056	1000.0	-1000.0	-0.015	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	252.0	93.0	-0.047	0.037	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	132.0	45.0	-0.034	0.049	1000.0	-1000.0	-0.028	-1000.0
Canonical Wnt signaling pathway	2.0	151.0	51.0	-0.085	0.068	1000.0	-1000.0	-0.029	-1000.0
IL6-mediated signaling events	2.0	202.0	75.0	-0.079	0.073	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	167.0	76.0	-0.028	0.054	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by STAT5	2.0	51.0	22.0	-0.071	0.032	1000.0	-1000.0	-0.021	-1000.0
Class I PI3K signaling events	2.0	158.0	73.0	-0.03	0.045	1000.0	-1000.0	-0.02	-1000.0
BCR signaling pathway	2.0	242.0	99.0	-0.049	0.055	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Rods	2.0	108.0	52.0	-0.078	0.061	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling in keratinocytes	2.0	128.0	43.0	-0.031	0.042	1000.0	-1000.0	-0.013	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	37.0	17.0	-0.015	0.043	1000.0	-1000.0	-0.011	-1000.0
Aurora B signaling	2.0	166.0	67.0	-0.085	0.043	1000.0	-1000.0	-0.025	-1000.0
LPA4-mediated signaling events	1.0	20.0	12.0	-0.023	0.001	1000.0	-1000.0	-0.016	-1000.0
ErbB2/ErbB3 signaling events	1.0	72.0	65.0	-0.039	0.067	1000.0	-1000.0	-0.03	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	28.0	23.0	0.002	0.038	1000.0	-1000.0	-0.013	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	61.0	34.0	-0.023	0.057	1000.0	-1000.0	-0.02	-1000.0
Canonical NF-kappaB pathway	1.0	41.0	39.0	-0.018	0.062	1000.0	-1000.0	-0.021	-1000.0
BARD1 signaling events	1.0	57.0	57.0	-0.049	0.062	1000.0	-1000.0	-0.028	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	31.0	28.0	-0.025	0.038	1000.0	-1000.0	-0.011	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	83.0	54.0	-0.035	0.039	1000.0	-1000.0	-0.023	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.0	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	30.0	17.0	-0.03	0.048	1000.0	-1000.0	-0.022	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.011	0.026	1000.0	-1000.0	0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	118.0	85.0	-0.131	0.052	1000.0	-1000.0	-0.04	-1000.0
Aurora A signaling	1.0	89.0	60.0	-0.022	0.047	1000.0	-1000.0	-0.016	-1000.0
p75(NTR)-mediated signaling	1.0	241.0	125.0	-0.087	0.061	1000.0	-1000.0	-0.025	-1000.0
EPO signaling pathway	1.0	76.0	55.0	-0.075	0.048	1000.0	-1000.0	-0.025	-1000.0
amb2 Integrin signaling	1.0	158.0	82.0	-0.026	0.063	1000.0	-1000.0	-0.013	-1000.0
Ceramide signaling pathway	1.0	136.0	76.0	-0.046	0.064	1000.0	-1000.0	-0.018	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	62.0	37.0	-0.027	0.048	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	1.0	70.0	40.0	-0.053	0.053	1000.0	-1000.0	-0.024	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	82.0	82.0	-0.018	0.05	1000.0	-1000.0	-0.039	-1000.0
S1P5 pathway	1.0	30.0	17.0	-0.025	0.027	1000.0	-1000.0	-0.006	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	99.0	52.0	-0.054	0.064	1000.0	-1000.0	-0.02	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	107.0	83.0	-0.031	0.058	1000.0	-1000.0	-0.017	-1000.0
FoxO family signaling	1.0	81.0	64.0	-0.038	0.041	1000.0	-1000.0	-0.027	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	58.0	36.0	-0.036	0.043	1000.0	-1000.0	-0.027	-1000.0
Atypical NF-kappaB pathway	1.0	43.0	31.0	-0.007	0.028	1000.0	-1000.0	-0.009	-1000.0
Regulation of p38-alpha and p38-beta	1.0	58.0	54.0	-0.043	0.059	1000.0	-1000.0	-0.034	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	49.0	31.0	-0.032	0.034	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	190.0	125.0	-0.03	0.043	1000.0	-1000.0	-0.022	-1000.0
TCGA08_rtk_signaling	1.0	34.0	26.0	-0.056	0.062	1000.0	-1000.0	-0.006	-1000.0
Regulation of Telomerase	1.0	162.0	102.0	-0.066	0.058	1000.0	-1000.0	-0.014	-1000.0
EGFR-dependent Endothelin signaling events	1.0	30.0	21.0	-0.015	0.041	1000.0	-1000.0	-0.028	-1000.0
Insulin Pathway	1.0	126.0	74.0	-0.043	0.059	1000.0	-1000.0	-0.021	-1000.0
S1P3 pathway	1.0	59.0	42.0	-0.03	0.038	1000.0	-1000.0	-0.024	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	162.0	120.0	-0.046	0.075	1000.0	-1000.0	-0.031	-1000.0
PDGFR-beta signaling pathway	1.0	149.0	97.0	-0.028	0.063	1000.0	-1000.0	-0.024	-1000.0
S1P4 pathway	1.0	47.0	25.0	-0.025	0.038	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.014	0.042	1000.0	-1000.0	0.016	-1000.0
p38 MAPK signaling pathway	1.0	52.0	44.0	-0.034	0.049	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class II	0.0	66.0	75.0	-0.066	0.069	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	0.0	35.0	69.0	-0.032	0.057	1000.0	-1000.0	-0.029	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.01	0.059	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	0.0	29.0	43.0	-0.041	0.047	1000.0	-1000.0	-0.025	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.037	1000.0	-1000.0	-0.009	-1000.0
Insulin-mediated glucose transport	0.0	23.0	32.0	-0.003	0.05	1000.0	-1000.0	-0.011	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	66.0	68.0	-0.041	0.047	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class I	0.0	88.0	104.0	-0.04	0.065	1000.0	-1000.0	-0.027	-1000.0
Effects of Botulinum toxin	0.0	8.0	26.0	-0.0	0.046	1000.0	-1000.0	-0.001	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	18.0	27.0	-0.0	0.066	1000.0	-1000.0	-0.016	-1000.0
Arf6 trafficking events	0.0	20.0	71.0	-0.037	0.049	1000.0	-1000.0	-0.021	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	87.0	88.0	-0.043	0.047	1000.0	-1000.0	-0.056	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	24.0	33.0	-0.043	0.068	1000.0	-1000.0	-0.018	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.034	1000.0	-1000.0	-0.003	-1000.0
Signaling events mediated by PRL	0.0	25.0	34.0	-0.031	0.041	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.027	0.027	1000.0	-1000.0	-0.016	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.001	0.05	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.067	1000.0	-1000.0	0.0	-1000.0
Total	278	19261	7203	-9.39582971591	6.39833451132	131000	-131000	-3.02616896033	-131000