Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events regulated by Ret tyrosine kinase	9.0	809.0	82.0	-0.133	0.026	1000.0	-1000.0	-0.047	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	374.0	46.0	-0.448	0.028	1000.0	-1000.0	-0.088	-1000.0
Endothelins	6.0	627.0	96.0	-0.133	0.026	1000.0	-1000.0	-0.047	-1000.0
HIF-1-alpha transcription factor network	5.0	383.0	76.0	-0.203	0.032	1000.0	-1000.0	-0.079	-1000.0
IL4-mediated signaling events	5.0	471.0	91.0	-0.52	0.394	1000.0	-1000.0	-0.116	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	222.0	44.0	-0.061	0.025	1000.0	-1000.0	-0.02	-1000.0
TCR signaling in naïve CD8+ T cells	5.0	476.0	93.0	-0.086	0.034	1000.0	-1000.0	-0.037	-1000.0
IL23-mediated signaling events	5.0	331.0	60.0	-0.293	0.039	1000.0	-1000.0	-0.082	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	155.0	34.0	-0.026	0.026	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by the Hedgehog family	4.0	211.0	52.0	-0.071	0.035	1000.0	-1000.0	-0.034	-1000.0
p75(NTR)-mediated signaling	4.0	594.0	125.0	-0.071	0.057	1000.0	-1000.0	-0.057	-1000.0
Glucocorticoid receptor regulatory network	4.0	513.0	114.0	-0.341	0.183	1000.0	-1000.0	-0.044	-1000.0
Reelin signaling pathway	4.0	260.0	56.0	-0.076	0.05	1000.0	-1000.0	-0.032	-1000.0
IL6-mediated signaling events	4.0	321.0	75.0	-0.118	0.028	1000.0	-1000.0	-0.056	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	321.0	68.0	-0.168	0.118	1000.0	-1000.0	-0.075	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	305.0	74.0	-0.079	0.054	1000.0	-1000.0	-0.05	-1000.0
TCGA08_retinoblastoma	4.0	37.0	8.0	-0.017	0.022	1000.0	-1000.0	-0.002	-1000.0
IGF1 pathway	4.0	259.0	57.0	-0.046	0.043	1000.0	-1000.0	-0.031	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	491.0	120.0	-0.127	0.104	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling events	4.0	20.0	5.0	-0.03	0.024	1000.0	-1000.0	0.007	-1000.0
ErbB2/ErbB3 signaling events	3.0	238.0	65.0	-0.149	0.034	1000.0	-1000.0	-0.055	-1000.0
IL12-mediated signaling events	3.0	331.0	87.0	-0.124	0.046	1000.0	-1000.0	-0.074	-1000.0
Syndecan-1-mediated signaling events	3.0	131.0	34.0	-0.076	0.025	1000.0	-1000.0	-0.031	-1000.0
Thromboxane A2 receptor signaling	3.0	325.0	105.0	-0.1	0.036	1000.0	-1000.0	-0.037	-1000.0
BMP receptor signaling	3.0	256.0	81.0	-0.072	0.058	1000.0	-1000.0	-0.041	-1000.0
EPO signaling pathway	3.0	167.0	55.0	-0.006	0.053	1000.0	-1000.0	-0.04	-1000.0
PDGFR-alpha signaling pathway	3.0	169.0	44.0	-0.11	0.035	1000.0	-1000.0	-0.034	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	198.0	52.0	-0.116	0.049	1000.0	-1000.0	-0.036	-1000.0
FAS signaling pathway (CD95)	3.0	150.0	47.0	-0.089	0.041	1000.0	-1000.0	-0.023	-1000.0
Retinoic acid receptors-mediated signaling	3.0	191.0	58.0	-0.131	0.048	1000.0	-1000.0	-0.027	-1000.0
EPHB forward signaling	3.0	325.0	85.0	-0.063	0.109	1000.0	-1000.0	-0.055	-1000.0
Effects of Botulinum toxin	3.0	94.0	26.0	-0.104	0.026	1000.0	-1000.0	-0.012	-1000.0
Wnt signaling	3.0	21.0	7.0	-0.029	0.016	1000.0	-1000.0	-0.016	-1000.0
LPA receptor mediated events	3.0	354.0	102.0	-0.088	0.032	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	277.0	76.0	-0.06	0.045	1000.0	-1000.0	-0.048	-1000.0
Syndecan-4-mediated signaling events	3.0	230.0	67.0	-0.054	0.036	1000.0	-1000.0	-0.032	-1000.0
Plasma membrane estrogen receptor signaling	3.0	334.0	86.0	-0.106	0.068	1000.0	-1000.0	-0.046	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	310.0	88.0	-0.099	0.036	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling in keratinocytes	3.0	145.0	43.0	-0.046	0.028	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	279.0	78.0	-0.084	0.032	1000.0	-1000.0	-0.042	-1000.0
LPA4-mediated signaling events	2.0	30.0	12.0	-0.075	-0.0	1000.0	-1000.0	-0.023	-1000.0
Caspase cascade in apoptosis	2.0	176.0	74.0	-0.072	0.057	1000.0	-1000.0	-0.034	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	291.0	136.0	-0.108	0.056	1000.0	-1000.0	-0.037	-1000.0
Coregulation of Androgen receptor activity	2.0	167.0	76.0	-0.187	0.035	1000.0	-1000.0	-0.021	-1000.0
BARD1 signaling events	2.0	157.0	57.0	-0.032	0.039	1000.0	-1000.0	-0.033	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	160.0	54.0	-0.081	0.038	1000.0	-1000.0	-0.038	-1000.0
Ephrin A  reverse signaling	2.0	15.0	7.0	-0.012	0.018	1000.0	-1000.0	-0.011	-1000.0
Noncanonical Wnt signaling pathway	2.0	67.0	26.0	-0.05	0.026	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	2.0	100.0	39.0	-0.049	0.026	1000.0	-1000.0	-0.017	-1000.0
Arf6 signaling events	2.0	163.0	62.0	-0.05	0.05	1000.0	-1000.0	-0.032	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	252.0	85.0	-0.053	0.026	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by PTP1B	2.0	188.0	76.0	-0.1	0.039	1000.0	-1000.0	-0.033	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	150.0	61.0	-0.092	0.047	1000.0	-1000.0	-0.037	-1000.0
Glypican 1 network	2.0	129.0	48.0	-0.1	0.049	1000.0	-1000.0	-0.032	-1000.0
amb2 Integrin signaling	2.0	212.0	82.0	-0.098	0.039	1000.0	-1000.0	-0.03	-1000.0
Nectin adhesion pathway	2.0	152.0	63.0	-0.03	0.045	1000.0	-1000.0	-0.054	-1000.0
Ceramide signaling pathway	2.0	163.0	76.0	-0.06	0.057	1000.0	-1000.0	-0.029	-1000.0
TRAIL signaling pathway	2.0	112.0	48.0	-0.027	0.042	1000.0	-1000.0	-0.027	-1000.0
ceramide signaling pathway	2.0	122.0	49.0	-0.036	0.036	1000.0	-1000.0	-0.036	-1000.0
Ephrin B reverse signaling	2.0	109.0	48.0	-0.017	0.031	1000.0	-1000.0	-0.028	-1000.0
S1P1 pathway	2.0	73.0	36.0	-0.067	0.025	1000.0	-1000.0	-0.038	-1000.0
Integrins in angiogenesis	2.0	208.0	84.0	-0.067	0.046	1000.0	-1000.0	-0.044	-1000.0
Canonical Wnt signaling pathway	2.0	123.0	51.0	-0.092	0.127	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	70.0	31.0	-0.05	0.025	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	2.0	117.0	52.0	-0.038	0.04	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by STAT5	2.0	51.0	22.0	-0.116	0.026	1000.0	-1000.0	-0.03	-1000.0
BCR signaling pathway	2.0	240.0	99.0	-0.049	0.054	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	2.0	216.0	97.0	-0.063	0.095	1000.0	-1000.0	-0.052	-1000.0
Visual signal transduction: Rods	2.0	136.0	52.0	-0.051	0.043	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	1.0	101.0	69.0	-0.1	0.044	1000.0	-1000.0	-0.042	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.021	0.026	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Cones	1.0	59.0	38.0	-0.014	0.029	1000.0	-1000.0	-0.025	-1000.0
Osteopontin-mediated events	1.0	46.0	38.0	-0.039	0.047	1000.0	-1000.0	-0.043	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	29.0	17.0	-0.02	0.028	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	1.0	119.0	69.0	-0.015	0.041	1000.0	-1000.0	-0.033	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	5.0	5.0	0.014	0.03	1000.0	-1000.0	0.004	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	80.0	65.0	-0.143	0.053	1000.0	-1000.0	-0.042	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	140.0	97.0	-0.082	0.05	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	1.0	72.0	53.0	-0.053	0.058	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	41.0	37.0	-0.02	0.052	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by HDAC Class III	1.0	53.0	40.0	-0.063	0.047	1000.0	-1000.0	-0.027	-1000.0
S1P5 pathway	1.0	20.0	17.0	-0.013	0.026	1000.0	-1000.0	-0.016	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	111.0	83.0	-0.057	0.045	1000.0	-1000.0	-0.029	-1000.0
Syndecan-3-mediated signaling events	1.0	50.0	35.0	-0.077	0.047	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	1.0	96.0	58.0	-0.074	0.053	1000.0	-1000.0	-0.038	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	72.0	45.0	-0.036	0.054	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	187.0	125.0	-0.034	0.056	1000.0	-1000.0	-0.049	-1000.0
IL27-mediated signaling events	1.0	78.0	51.0	-0.1	0.047	1000.0	-1000.0	-0.046	-1000.0
TCGA08_rtk_signaling	1.0	36.0	26.0	-0.047	0.07	1000.0	-1000.0	-0.009	-1000.0
Class I PI3K signaling events	1.0	110.0	73.0	-0.022	0.049	1000.0	-1000.0	-0.036	-1000.0
EGFR-dependent Endothelin signaling events	1.0	41.0	21.0	-0.026	0.047	1000.0	-1000.0	-0.038	-1000.0
S1P3 pathway	1.0	56.0	42.0	-0.021	0.044	1000.0	-1000.0	-0.045	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	38.0	33.0	-0.053	0.055	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.005	-1000.0
FOXM1 transcription factor network	1.0	57.0	51.0	-0.079	0.035	1000.0	-1000.0	-0.109	-1000.0
S1P4 pathway	1.0	37.0	25.0	-0.024	0.039	1000.0	-1000.0	-0.026	-1000.0
Regulation of Androgen receptor activity	1.0	136.0	70.0	-0.23	0.034	1000.0	-1000.0	-0.045	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	20.0	17.0	-0.007	0.041	1000.0	-1000.0	-0.022	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	-0.013	0.044	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	0.0	30.0	39.0	-0.036	0.058	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	0.0	40.0	75.0	-0.04	0.067	1000.0	-1000.0	-0.027	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	17.0	28.0	-0.013	0.046	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.007	0.052	1000.0	-1000.0	-0.035	-1000.0
Aurora A signaling	0.0	23.0	60.0	-0.034	0.054	1000.0	-1000.0	-0.026	-1000.0
Arf6 downstream pathway	0.0	22.0	43.0	-0.045	0.046	1000.0	-1000.0	-0.021	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.0	0.038	1000.0	-1000.0	-0.011	-1000.0
PLK1 signaling events	0.0	59.0	85.0	-0.02	0.039	1000.0	-1000.0	-0.03	-1000.0
Insulin-mediated glucose transport	0.0	28.0	32.0	-0.042	0.045	1000.0	-1000.0	-0.026	-1000.0
IFN-gamma pathway	0.0	42.0	68.0	-0.031	0.067	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	19.0	68.0	-0.046	0.065	1000.0	-1000.0	-0.026	-1000.0
IL1-mediated signaling events	0.0	56.0	62.0	-0.019	0.061	1000.0	-1000.0	-0.03	-1000.0
HIF-2-alpha transcription factor network	0.0	31.0	43.0	-0.061	0.062	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class I	0.0	89.0	104.0	-0.043	0.065	1000.0	-1000.0	-0.032	-1000.0
TCGA08_p53	0.0	5.0	7.0	-0.01	0.026	1000.0	-1000.0	-0.014	-1000.0
FoxO family signaling	0.0	35.0	64.0	-0.042	0.073	1000.0	-1000.0	-0.058	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.012	0.024	1000.0	-1000.0	-0.026	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	21.0	36.0	-0.042	0.047	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	0.0	15.0	31.0	-0.009	0.027	1000.0	-1000.0	-0.024	-1000.0
Regulation of p38-alpha and p38-beta	0.0	38.0	54.0	-0.04	0.059	1000.0	-1000.0	-0.048	-1000.0
Glypican 2 network	0.0	3.0	4.0	0.017	0.029	1000.0	-1000.0	0.006	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.011	0.055	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	0.0	33.0	71.0	-0.045	0.047	1000.0	-1000.0	-0.026	-1000.0
Regulation of Telomerase	0.0	94.0	102.0	-0.068	0.051	1000.0	-1000.0	-0.04	-1000.0
Insulin Pathway	0.0	59.0	74.0	-0.018	0.065	1000.0	-1000.0	-0.054	-1000.0
VEGFR1 specific signals	0.0	17.0	56.0	-0.025	0.053	1000.0	-1000.0	-0.04	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.007	0.029	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by PRL	0.0	20.0	34.0	-0.046	0.036	1000.0	-1000.0	-0.044	-1000.0
p38 MAPK signaling pathway	0.0	21.0	44.0	-0.015	0.046	1000.0	-1000.0	-0.021	-1000.0
Arf1 pathway	0.0	14.0	54.0	-0.005	0.037	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.065	1000.0	-1000.0	0.0	-1000.0
Aurora B signaling	0.0	43.0	67.0	-0.082	0.066	1000.0	-1000.0	-0.034	-1000.0
Total	243	18670	7203	-9.05436755204	6.34941305661	131000	-131000	-4.63272696522	-131000