E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.089 0.152 -9999.0 0.0 -0.309 25.0 25.0 KLHL20 -0.024 0.066 -9999.0 0.0 -0.229 1.0 1.0 CYFIP2 -0.013 0.115 0.237 2.0 -0.29 11.0 13.0 Rac1/GDP -0.053 0.093 -9999.0 0.0 -0.237 8.0 8.0 ENAH -0.092 0.151 -9999.0 0.0 -0.31 24.0 24.0 AP1M1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.036 -9999.0 0.0 -0.29 1.0 1.0 CDC42/GTP -0.045 0.05 -9999.0 0.0 -0.186 2.0 2.0 ABI1/Sra1/Nap1 -0.038 0.042 -9999.0 0.0 -0.138 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.02 0.079 0.19 1.0 -0.161 11.0 12.0 RAPGEF1 -0.095 0.138 -9999.0 0.0 -0.284 25.0 25.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.085 0.16 -9999.0 0.0 -0.312 25.0 25.0 CRK -0.094 0.149 -9999.0 0.0 -0.297 26.0 26.0 E-cadherin/gamma catenin/alpha catenin 0.029 0.059 -9999.0 0.0 -0.171 6.0 6.0 alphaE/beta7 Integrin 0.03 0.049 0.184 1.0 -0.203 3.0 4.0 IQGAP1 0.009 0.069 -9999.0 0.0 -0.29 4.0 4.0 NCKAP1 0.021 0.035 -9999.0 0.0 -0.29 1.0 1.0 Rap1/GTP/I-afadin 0.032 0.037 -9999.0 0.0 -0.156 2.0 2.0 DLG1 -0.059 0.141 -9999.0 0.0 -0.346 14.0 14.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.046 0.036 -9999.0 0.0 -0.135 8.0 8.0 MLLT4 0.014 0.049 -9999.0 0.0 -0.29 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.048 0.039 0.173 4.0 -0.156 1.0 5.0 PI3K -0.057 0.046 -9999.0 0.0 -0.17 8.0 8.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.016 0.063 -9999.0 0.0 -0.2 6.0 6.0 TIAM1 0.03 0.059 0.237 4.0 -0.29 1.0 5.0 E-cadherin(dimer)/Ca2+ 0.022 0.064 -9999.0 0.0 -0.149 8.0 8.0 AKT1 -0.036 0.033 -9999.0 0.0 -0.163 1.0 1.0 PIK3R1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.004 0.089 -9999.0 0.0 -0.29 7.0 7.0 RhoA/GDP -0.054 0.092 -9999.0 0.0 -0.237 8.0 8.0 actin cytoskeleton organization -0.017 0.05 -9999.0 0.0 -0.167 1.0 1.0 CDC42/GDP -0.053 0.092 -9999.0 0.0 -0.237 8.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.005 0.057 -9999.0 0.0 -0.186 7.0 7.0 ITGB7 0.016 0.065 0.237 1.0 -0.29 3.0 4.0 RAC1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.027 0.068 -9999.0 0.0 -0.16 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.015 0.056 -9999.0 0.0 -0.143 8.0 8.0 mol:GDP -0.067 0.098 -9999.0 0.0 -0.267 8.0 8.0 CDC42/GTP/IQGAP1 0.02 0.044 -9999.0 0.0 -0.164 4.0 4.0 JUP 0.028 0.024 0.237 1.0 -9999.0 0.0 1.0 p120 catenin/RhoA/GDP -0.048 0.098 -9999.0 0.0 -0.24 8.0 8.0 RAC1/GTP/IQGAP1 0.023 0.044 -9999.0 0.0 -0.167 4.0 4.0 PIP5K1C/AP1M1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.034 -9999.0 0.0 -9999.0 0.0 0.0 NME1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.088 0.152 -9999.0 0.0 -0.31 24.0 24.0 regulation of cell-cell adhesion -0.044 0.038 -9999.0 0.0 -0.145 8.0 8.0 WASF2 -0.015 0.028 -9999.0 0.0 -0.085 2.0 2.0 Rap1/GTP -0.045 0.058 -9999.0 0.0 -0.23 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.041 0.077 -9999.0 0.0 -0.155 9.0 9.0 CCND1 -0.013 0.04 -9999.0 0.0 -9999.0 0.0 0.0 VAV2 -0.08 0.154 -9999.0 0.0 -0.41 2.0 2.0 RAP1/GDP -0.034 0.078 -9999.0 0.0 -0.217 3.0 3.0 adherens junction assembly -0.086 0.148 -9999.0 0.0 -0.302 24.0 24.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.009 0.07 -9999.0 0.0 -0.153 10.0 10.0 E-cadherin/beta catenin -0.015 0.076 -9999.0 0.0 -0.258 7.0 7.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.092 0.152 -9999.0 0.0 -0.309 25.0 25.0 PIK3CA 0.013 0.049 -9999.0 0.0 -0.29 2.0 2.0 Rac1/GTP -0.043 0.081 -9999.0 0.0 -0.25 1.0 1.0 E-cadherin/beta catenin/alpha catenin 0.016 0.066 -9999.0 0.0 -0.172 8.0 8.0 ITGAE 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.086 0.163 -9999.0 0.0 -0.318 25.0 25.0