		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
ZFPM1	24 (39%)	38	0.80406	1	0.81625	1	0.71768	1	0.87327	1	0.37583	1	0.74668	1	0.82287	1	0.92127	1	0.38108	1	0.74051	1
LACTB	19 (31%)	43	0.43921	1	0.68712	1	0.68599	1	0.56428	1	1	1	0.31656	1	0.37693	1	0.75049	1	0.32197	1	0.17847	1
CCDC102A	17 (27%)	45	0.01863	1	0.93436	1	0.67029	1	0.50612	1	0.97426	1	0.82493	1	0.49774	1	0.46925	1	0.80829	1	0.50743	1
ZNF517	13 (21%)	49	0.1638	1	0.98064	1	1	1	NA	NA	0.82171	1	0.951	1	0.17286	1	0.6939	1	0.7272	1	0.77474	1
MAL2	11 (18%)	51	0.49488	1	0.31341	1	1	1	1	1	0.25148	1	0.5099	1	0.2194	1	0.26746	1	1	1	0.86852	1
CLDN23	10 (16%)	52	0.57145	1	0.25028	1	1	1	0.35142	1	0.02905	1	0.21056	1	0.097699	1	0.18197	1	0.41395	1	0.54473	1
TOR3A	12 (19%)	50	0.61191	1	0.01374	1	0.15278	1	0.31559	1	0.67432	1	0.00482	1	1	1	0.84161	1	0.91063	1	0.8059	1
USP42	15 (24%)	47	0.54936	1	0.04508	1	0.39553	1	0.46634	1	1	1	0.95973	1	0.45836	1	0.8737	1	0.91314	1	0.90224	1
TP53	12 (19%)	50	0.1353	1	0.78898	1	0.39553	1	0.46711	1	0.02035	1	0.66477	1	0.01624	1	0.67195	1	0.0065999	1	0.17957	1
APOE	7 (11%)	55	1	1	0.5984	1	1	1	0.3813	1	0.058299	1	0.39764	1	0.19443	1	0.79114	1	0.4169	1	1	1
ZAR1	11 (18%)	51	0.64743	1	0.66733	1	1	1	0.79282	1	0.62234	1	0.86829	1	0.71415	1	0.97079	1	1	1	0.60312	1
ASPDH	8 (13%)	54	0.30002	1	0.69061	1	1	1	0.31522	1	0.02254	1	0.39258	1	0.47303	1	0.03053	1	0.21219	1	0.081829	1
KCNK17	9 (15%)	53	0.20386	1	0.04028	1	0.01784	1	0.44077	1	0.10484	1	0.0087999	1	0.89072	1	0.54576	1	0.71778	1	0.4458	1
LZTR1	6 (10%)	56	0.051099	1	0.84966	1	1	1	NA	NA	0.088389	1	0.11786	1	0.3993	1	0.01476	1	1	1	0.45515	1
ERCC2	10 (16%)	52	1	1	0.22914	1	0.037681	1	0.23353	1	0.47932	1	0.16928	1	0.59733	1	0.27024	1	0.33571	1	0.20781	1
RINL	8 (13%)	54	0.3399	1	0.67739	1	1	1	0.57974	1	0.46837	1	0.27593	1	0.75853	1	0.17162	1	0.35	1	0.74829	1
SYT8	8 (13%)	54	0.4418	1	0.43979	1	1	1	1	1	0.04122	1	0.17745	1	1	1	0.18515	1	0.74968	1	0.4955	1
LRIG1	16 (26%)	46	0.53861	1	0.95881	1	1	1	1	1	0.86534	1	0.61164	1	0.36024	1	0.43413	1	0.57585	1	0.90329	1
C1ORF106	9 (15%)	53	0.84102	1	0.47142	1	0.63889	1	0.04748	1	0.3429	1	0.76027	1	0.47389	1	0.69434	1	0.053609	1	1	1
GPRIN2	8 (13%)	54	0.86776	1	0.38398	1	1	1	0.69283	1	0.68155	1	0.40011	1	0.58033	1	0.75289	1	0.59901	1	0.18095	1
CTNNB1	7 (11%)	55	0.73316	1	0.18424	1	1	1	0.39436	1	0.01818	1	0.02323	1	0.00075999	0.452	0.17846	1	0.1225	1	0.71238	1
C16ORF3	5 (8%)	57	0.85775	1	0.00066999	0.452	1	1	0.78994	1	0.80273	1	0.81341	1	0.581	1	1	1	0.72577	1	0.83568	1
CCDC105	6 (10%)	56	1	1	0.0109	1	0.22619	1	0.67408	1	0.93797	1	0.79395	1	1	1	0.054119	1	0.21764	1	0.20702	1
RGS9BP	8 (13%)	54	0.72559	1	0.63435	1	1	1	0.12991	1	1	1	0.93272	1	0.21811	1	0.96216	1	0.34269	1	0.74916	1
HHIPL1	6 (10%)	56	0.2742	1	0.43337	1	0.48413	1	NA	NA	0.62641	1	0.5166	1	0.20406	1	0.42491	1	0.20289	1	0.33306	1
C10ORF95	6 (10%)	56	0.19874	1	0.37897	1	1	1	NA	NA	0.51544	1	1	1	0.48628	1	0.36123	1	1	1	1	1
TSC22D2	8 (13%)	54	0.94671	1	0.54328	1	1	1	0.95375	1	0.78214	1	0.81678	1	0.76016	1	0.43156	1	0.34762	1	1	1
NOXA1	5 (8%)	57	0.14074	1	0.51505	1	1	1	NA	NA	0.2217	1	0.44097	1	0.29472	1	0.35021	1	0.25436	1	0.72	1
THEM4	5 (8%)	57	0.28005	1	0.76922	1	1	1	NA	NA	0.43781	1	0.87599	1	0.1776	1	0.10599	1	0.22881	1	0.25909	1
ATXN1	10 (16%)	52	0.55247	1	0.13887	1	0.6	1	0.91504	1	0.24026	1	0.65767	1	0.28737	1	0.87182	1	0.23475	1	0.31557	1
PLIN5	5 (8%)	57	0.50072	1	0.69604	1	1	1	0.38095	1	0.79998	1	0.66532	1	0.26907	1	0.2689	1	0.5111	1	0.048	1
OPRD1	12 (19%)	50	0.96671	1	0.4361	1	0.65459	1	0.48541	1	0.79969	1	0.95965	1	0.29636	1	0.61417	1	1	1	0.51179	1
KRTAP4-5	5 (8%)	57	0.63233	1	0.28866	1	0.48413	1	NA	NA	0.90989	1	0.87662	1	1	1	0.84161	1	0.43579	1	1	1
C19ORF10	7 (11%)	55	0.78115	1	0.42354	1	0.6	1	0.39297	1	0.23959	1	0.12321	1	0.55138	1	0.86081	1	0.63846	1	0.71229	1
AATK	6 (10%)	56	0.13962	1	0.32948	1	1	1	NA	NA	0.43686	1	0.35287	1	1	1	0.54483	1	1	1	0.61765	1
SARM1	6 (10%)	56	0.2093	1	0.42297	1	0.6	1	0.69447	1	0.17553	1	0.11378	1	0.26896	1	0.8372	1	0.5103	1	0.079989	1
TRIOBP	10 (16%)	52	0.62124	1	0.22992	1	0.58333	1	0.12896	1	1	1	0.11041	1	0.71122	1	0.87066	1	1	1	0.77425	1
ZNF598	12 (19%)	50	0.10963	1	0.31421	1	1	1	0.74653	1	0.49038	1	0.95086	1	1	1	0.22591	1	0.90216	1	1	1
WDR34	5 (8%)	57	0.62986	1	0.82936	1	0.48413	1	NA	NA	0.86521	1	0.8143	1	0.84275	1	0.54836	1	0.84218	1	0.3335	1
ZNF628	7 (11%)	55	0.20954	1	0.92748	1	1	1	0.67575	1	0.31224	1	0.116	1	0.092969	1	0.49999	1	0.28334	1	0.54497	1
BTBD11	6 (10%)	56	1	1	0.31206	1	1	1	NA	NA	0.48114	1	1	1	0.48981	1	0.18442	1	0.72436	1	0.33553	1
IRX3	5 (8%)	57	0.14201	1	0.7106	1	0.48413	1	NA	NA	0.52078	1	0.11785	1	0.17675	1	0.7777	1	0.23009	1	0.45476	1
FPGS	5 (8%)	57	1	1	1	1	1	1	0.35132	1	0.66455	1	0.5997	1	0.056849	1	0.62209	1	0.82492	1	0.61515	1
MEN1	5 (8%)	57	0.42	1	0.04722	1	0.48413	1	NA	NA	0.0128	1	0.0063799	1	0.20271	1	0.04264	1	0.13437	1	0.20362	1
BHLHE22	5 (8%)	57	0.42312	1	0.073519	1	1	1	0.91534	1	0.11902	1	0.81507	1	0.58206	1	0.83639	1	0.72676	1	0.83453	1
DMKN	3 (5%)	59	1	1	0.32645	1	0.46429	1	NA	NA	0.61859	1	0.44283	1	0.0064399	1	0.56721	1	0.25463	1	1	1
OBSCN	18 (29%)	44	0.31028	1	0.52072	1	1	1	0.5438	1	0.67109	1	0.80363	1	0.15136	1	0.4974	1	1	1	0.3856	1
PANK2	5 (8%)	57	0.62871	1	0.43153	1	0.22619	1	0.35226	1	0.11564	1	0.051319	1	0.43014	1	0.34797	1	1	1	0.25634	1
RREB1	5 (8%)	57	0.7256	1	0.85223	1	0.20635	1	NA	NA	0.61991	1	1	1	0.529	1	0.54552	1	0.17086	1	0.35268	1
RNF149	4 (6%)	58	0.33963	1	0.03643	1	0.58333	1	0.9545	1	0.43768	1	0.60238	1	0.3136	1	0.26058	1	0.6646	1	0.17322	1
GLTPD2	6 (10%)	56	0.87638	1	0.84126	1	0.48413	1	NA	NA	0.82928	1	0.39944	1	0.55243	1	0.52657	1	0.87328	1	0.13264	1
SNED1	5 (8%)	57	0.63297	1	0.31458	1	0.46429	1	NA	NA	0.39815	1	0.66763	1	0.094149	1	0.66273	1	1	1	0.54447	1
TPO	12 (19%)	50	0.26092	1	0.29865	1	0.10159	1	0.69652	1	0.17247	1	0.12536	1	0.098069	1	0.34403	1	1	1	0.17255	1
PTPLA	4 (6%)	58	0.41786	1	0.32717	1	1	1	NA	NA	0.33855	1	0.44108	1	0.77597	1	1	1	0.77463	1	1	1
PRSS27	3 (5%)	59	1	1	0.90775	1	1	1	NA	NA	0.61798	1	0.050249	1	0.1307	1	1	1	0.61182	1	0.55353	1
CD320	4 (6%)	58	1	1	0.85082	1	1	1	NA	NA	0.73888	1	0.65762	1	0.39966	1	0.22769	1	0.23238	1	0.25995	1
SEMA5B	8 (13%)	54	0.33932	1	0.26798	1	0.31111	1	0.17467	1	0.39983	1	0.21395	1	0.64678	1	0.29689	1	0.35932	1	0.40801	1
CCDC150	4 (6%)	58	0.1772	1	0.8509	1	0.22619	1	0.6047	1	0.23829	1	0.11789	1	0.40158	1	0.21304	1	1	1	0.4531	1
TAF5	4 (6%)	58	1	1	0.77023	1	0.58333	1	0.95349	1	1	1	0.87702	1	0.0099999	1	0.11589	1	0.056599	1	0.01391	1
GARS	19 (31%)	43	0.076309	1	0.091279	1	0.22754	1	0.33486	1	0.34213	1	0.10289	1	0.11632	1	0.40049	1	0.21447	1	0.39684	1
MUC5B	22 (35%)	40	1	1	0.62721	1	1	1	0.81183	1	0.72792	1	0.67129	1	0.71857	1	0.61537	1	1	1	0.52999	1
KIAA1984	4 (6%)	58	0.42159	1	0.70927	1	0.22619	1	0.50184	1	0.12744	1	0.04902	1	0.03105	1	0.58361	1	0.66263	1	0.79231	1
SRPX	3 (5%)	59	0.75333	1	0.11413	1	1	1	NA	NA	0.61872	1	1	1	0.77552	1	0.71798	1	1	1	0.39867	1
TNIP2	5 (8%)	57	0.63116	1	0.70694	1	1	1	NA	NA	0.74016	1	0.87687	1	1	1	0.41227	1	1	1	0.45322	1
IDUA	8 (13%)	54	0.37965	1	0.85298	1	1	1	0.79311	1	0.51182	1	0.54913	1	0.20188	1	0.43172	1	0.45809	1	0.64817	1
RNF39	5 (8%)	57	0.72423	1	0.37712	1	0.6	1	0.79343	1	0.17508	1	0.26506	1	0.15764	1	0.70163	1	0.23974	1	0.6813	1
PABPC1	4 (6%)	58	0.4176	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SCRT1	3 (5%)	59	1	1	0.42727	1	0.46429	1	NA	NA	0.4731	1	0.61633	1	0.42586	1	0.7936	1	0.46889	1	1	1
MAP1S	5 (8%)	57	0.1571	1	0.27813	1	1	1	0.41523	1	0.39776	1	1	1	1	1	0.83447	1	0.42163	1	0.83668	1
NF1	7 (11%)	55	0.25337	1	0.90311	1	0.10159	1	0.39399	1	0.35893	1	0.18778	1	0.27932	1	0.88285	1	1	1	0.097579	1
AKAP2	4 (6%)	58	0.10727	1	0.43179	1	1	1	0.67533	1	0.73772	1	0.17306	1	0.53068	1	0.44198	1	0.823	1	0.35214	1
NOTCH2	5 (8%)	57	0.28034	1	0.8956	1	1	1	NA	NA	0.52184	1	0.11651	1	0.03161	1	0.3189	1	0.66334	1	0.7948	1
FANK1	4 (6%)	58	1	1	0.32465	1	1	1	NA	NA	0.85605	1	0.28934	1	0.77822	1	0.22949	1	0.77529	1	0.25763	1
NEFH	6 (10%)	56	0.050259	1	0.17281	1	0.48413	1	NA	NA	0.11404	1	0.050279	1	0.40033	1	0.20978	1	0.66546	1	0.45245	1
NPTX1	3 (5%)	59	0.63965	1	1	1	0.46429	1	NA	NA	1	1	0.81593	1	0.5835	1	0.79226	1	0.35304	1	0.55585	1
KBTBD13	9 (15%)	53	0.45681	1	0.11485	1	0.31111	1	0.79178	1	0.68663	1	0.11796	1	1	1	0.32793	1	1	1	0.60136	1
RASIP1	6 (10%)	56	0.35864	1	0.34865	1	1	1	NA	NA	0.04246	1	0.18736	1	0.056339	1	0.69524	1	0.41403	1	0.71415	1
AR	4 (6%)	58	0.41675	1	0.51451	1	1	1	0.95382	1	0.47626	1	0.44116	1	0.42783	1	1	1	0.25612	1	1	1
KNDC1	9 (15%)	53	0.35362	1	0.065179	1	1	1	0.55099	1	0.02604	1	0.32506	1	0.42089	1	0.36692	1	0.18741	1	0.38132	1
SEZ6L2	8 (13%)	54	0.38222	1	0.66555	1	1	1	0.7879	1	0.82848	1	1	1	0.46212	1	0.62775	1	1	1	0.84799	1
VARS	6 (10%)	56	1	1	0.42251	1	0.22619	1	0.38307	1	0.21456	1	0.066489	1	0.64582	1	0.86314	1	0.74774	1	1	1
IER5	3 (5%)	59	0.19748	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NMU	5 (8%)	57	0.9151	1	1	1	0.46429	1	NA	NA	0.070129	1	0.61846	1	1	1	0.54328	1	0.82409	1	0.61698	1
TMEM189	3 (5%)	59	0.19815	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ADAD2	4 (6%)	58	0.42105	1	0.57517	1	1	1	NA	NA	0.73842	1	0.17079	1	0.0089799	1	0.51061	1	0.055849	1	0.35214	1
PLEC	13 (21%)	49	0.42792	1	0.67172	1	0.33333	1	0.04605	1	0.20437	1	0.72031	1	0.59735	1	0.63551	1	0.14242	1	0.62414	1
RGMB	6 (10%)	56	0.65206	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CLIC6	5 (8%)	57	0.63088	1	1	1	0.20635	1	NA	NA	0.66692	1	0.11801	1	0.17787	1	0.58146	1	0.29582	1	1	1
ZNF814	3 (5%)	59	1	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DSPP	9 (15%)	53	0.6144	1	0.061209	1	1	1	0.69374	1	1	1	0.48133	1	0.44839	1	0.53643	1	0.90113	1	1	1
AMDHD1	10 (16%)	52	0.65627	1	0.75466	1	0.22619	1	0.35145	1	0.58538	1	0.13591	1	0.17403	1	0.85244	1	0.9042	1	0.6813	1
CRIPAK	10 (16%)	52	0.38485	1	0.92643	1	0.6	1	0.93522	1	0.49014	1	0.69002	1	0.89333	1	0.32897	1	0.4765	1	0.36626	1
NOM1	6 (10%)	56	1	1	0.31214	1	1	1	NA	NA	0.86487	1	1	1	1	1	0.787	1	0.41968	1	1	1
MAP7	3 (5%)	59	1	1	0.64794	1	0.46429	1	NA	NA	1	1	0.81377	1	0.57954	1	0.79321	1	1	1	0.55704	1
PTX4	3 (5%)	59	1	1	1	1	1	1	NA	NA	0.47176	1	0.19506	1	0.43145	1	1	1	0.2529	1	0.25443	1
LRP11	6 (10%)	56	1	1	0.081189	1	1	1	NA	NA	0.79921	1	0.66341	1	0.57879	1	0.93651	1	0.84024	1	0.83677	1
PDCD6	3 (5%)	59	0.30157	1	0.65038	1	0.46429	1	NA	NA	NA	NA	NA	NA	1	1	0.64013	1	1	1	1	1
SHOX2	3 (5%)	59	0.41188	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
UQCRFS1	5 (8%)	57	0.74954	1	0.58626	1	0.48413	1	NA	NA	1	1	0.87657	1	0.48649	1	0.20396	1	0.84287	1	0.33344	1
CTBP2	3 (5%)	59	0.75427	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
PRKAR1A	6 (10%)	56	0.61561	1	1	1	0.6	1	0.79447	1	0.27882	1	0.3993	1	0.10376	1	0.58696	1	0.04813	1	0.58862	1
JMJD4	3 (5%)	59	1	1	NA	NA	0.48413	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HSD17B1	4 (6%)	58	0.91511	1	0.04994	1	0.58333	1	0.50382	1	0.90743	1	0.0079899	1	1	1	0.84163	1	0.55254	1	0.79363	1
COQ2	5 (8%)	57	0.36198	1	0.76641	1	1	1	NA	NA	0.44096	1	0.60045	1	1	1	0.67287	1	0.54948	1	0.61971	1
FEZ2	3 (5%)	59	0.46741	1	0.35245	1	1	1	NA	NA	0.22153	1	0.81407	1	0.19315	1	0.79444	1	0.77356	1	0.5532	1
DLEU7	3 (5%)	59	0.52843	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
RNF135	3 (5%)	59	0.75394	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SPIRE2	3 (5%)	59	0.29865	1	0.03834	1	1	1	NA	NA	1	1	0.81473	1	1	1	0.79222	1	1	1	1	1
KRTAP5-5	3 (5%)	59	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SGK223	3 (5%)	59	0.75534	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
C9ORF66	5 (8%)	57	1	1	0.92602	1	1	1	NA	NA	1	1	0.51602	1	0.58124	1	0.93525	1	0.34732	1	0.54228	1
AQP7	3 (5%)	59	0.7551	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ADAMTS7	4 (6%)	58	0.1997	1	0.47855	1	0.087302	1	0.3495	1	0.091389	1	0.43705	1	0.082449	1	0.26042	1	0.1221	1	0.03907	1
PCDHB13	5 (8%)	57	0.39283	1	0.14139	1	0.48413	1	NA	NA	0.12858	1	0.35466	1	0.66673	1	0.060119	1	0.43646	1	0.45302	1
CSGALNACT2	3 (5%)	59	0.16001	1	0.03833	1	0.46429	1	NA	NA	0.77324	1	0.81261	1	0.58042	1	0.87401	1	0.34948	1	0.40212	1
HLA-A	3 (5%)	59	1	1	1	1	1	1	NA	NA	0.85572	1	0.19586	1	1	1	0.51049	1	0.77569	1	0.25691	1
MTFMT	3 (5%)	59	1	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
NLRP5	4 (6%)	58	0.91358	1	0.17046	1	0.46429	1	NA	NA	1	1	0.12062	1	0.77743	1	0.64177	1	1	1	0.077159	1
KCNJ11	4 (6%)	58	0.02074	1	0.70531	1	1	1	NA	NA	0.43777	1	0.22813	1	0.12631	1	0.053619	1	0.29045	1	0.25894	1
