rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(8), LIPT1(11)	821172	19	17	14	0	0	3	2	3	11	0	0.0552	0.146	1.000
2	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	384581	7	8	7	1	6	0	0	1	0	0	0.331	0.369	1.000
3	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CDO1(3), CSAD(4), GAD1(15), GAD2(15), GGT1(9)	2900087	49	43	37	8	16	6	5	11	11	0	0.0353	0.567	1.000
4	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(2), CDK2(5), CDK4(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(3), TP53(326)	3973129	378	245	232	89	99	90	47	65	73	4	7.33e-05	0.605	1.000
5	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5), TPI1(3)	802771	8	8	8	1	0	0	1	7	0	0	0.397	0.709	1.000
6	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(11), ALDH1A2(17), BCMO1(5), RDH5(2)	2048461	35	32	34	7	10	8	5	8	4	0	0.0769	0.726	1.000
7	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4)	4134598	86	62	75	10	28	19	12	18	9	0	3.96e-05	0.856	1.000
8	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4)	4134598	86	62	75	10	28	19	12	18	9	0	3.96e-05	0.856	1.000
9	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(4), CD4(4), HLA-DRB1(6)	912125	14	12	13	7	1	0	2	5	4	2	0.963	0.860	1.000
10	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(5), MAX(5), MYC(5), SP1(6), SP3(10), TP53(326), WT1(28)	3589323	385	247	236	101	102	96	53	63	67	4	0.000156	0.879	1.000
11	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), IL8(5), SLPI(2)	832960	16	15	15	7	2	3	2	3	6	0	0.794	0.958	1.000
12	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPX1(4), PRKCE(4)	3921206	100	77	93	24	25	15	11	33	16	0	0.0327	0.961	1.000
13	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	4	ALDH6A1(5), ALDOA(2), ALDOC(1), TPI1(3)	1518887	11	11	11	1	2	0	1	8	0	0	0.198	0.962	1.000
14	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), SDS(3)	6313572	115	79	103	15	36	22	18	24	15	0	7.61e-06	0.963	1.000
15	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(5), B3GNT1(5), FUT1(8), FUT2(6), FUT9(9), GCNT2(24), ST8SIA1(10)	2877199	67	53	62	17	20	8	8	22	8	1	0.0941	0.976	1.000
16	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(7), ACAT2(8), ACYP1(1), ECHS1(3), EHHADH(13), GCDH(6), HADHA(10), SDHB(3), SDS(3)	4069262	54	43	51	9	14	8	9	12	11	0	0.0190	0.976	1.000
17	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	2	BMP1(17), BMPR1B(14)	1523595	31	26	30	7	11	4	2	7	7	0	0.337	0.978	1.000
18	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), TP53(326)	4300352	359	241	217	81	102	85	44	57	67	4	2.40e-05	0.980	1.000
19	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	BGN(7), DCN(7), FMOD(8), KERA(7)	1501723	29	26	29	8	7	5	1	13	3	0	0.501	0.981	1.000
20	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(4), HGD(5)	1190363	12	10	11	3	0	1	5	4	2	0	0.300	0.986	1.000
21	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(3), GGT1(9), SHMT1(6), SHMT2(5)	1926709	24	24	22	7	6	1	3	2	12	0	0.664	0.991	1.000
22	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(12), SPCS1(2), SPCS3(2)	1621531	21	18	19	5	8	3	1	6	3	0	0.213	0.993	1.000
23	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	2	CD3D(4), CD3E(2)	428871	6	6	4	3	0	4	1	0	1	0	0.751	0.993	1.000
24	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), MIOX(3), UGDH(8)	4290041	75	57	63	13	21	17	9	14	14	0	0.0137	0.998	1.000
25	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(3), EHHADH(13), HADHA(10), SDS(3)	2543336	29	26	28	7	8	3	6	6	6	0	0.205	0.999	1.000
26	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(7), ACAA2(2), ACAT1(7), ACAT2(8), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), SDS(3)	4429277	62	51	59	13	13	12	12	13	12	0	0.0329	0.999	1.000
27	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(5), CBS(3), CTH(5), MUT(7)	2444165	23	19	23	4	9	1	6	3	4	0	0.0855	1.000	1.000
28	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(11), CD28(4), CD3D(4), CD3E(2), CD4(4)	1572475	25	23	22	8	3	4	5	8	5	0	0.541	1.000	1.000
29	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(6), RANBP2(24), RANGAP1(4)	4139507	36	31	34	4	7	6	5	10	8	0	0.0208	1.000	1.000
30	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(11), ACO2(7), FH(9), IDH2(16), MDH1(8), MDH2(3), SDHB(3), SUCLA2(6)	4267223	63	57	57	13	13	12	9	18	11	0	0.0454	1.000	1.000
31	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(6), GRIA2(23), PPP1R1B(1)	1746011	32	28	32	11	13	5	3	8	3	0	0.380	1.000	1.000
32	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(11), CYP2C9(8)	1088534	19	19	18	5	2	7	2	7	1	0	0.431	1.000	1.000
33	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(5), ST6GALNAC4(3), ST8SIA1(10)	2831569	31	28	29	7	10	7	3	5	6	0	0.159	1.000	1.000
34	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GGT1(9), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH2(16), MGST1(2), MGST2(2), MGST3(1), PGD(7)	8706306	139	86	125	26	31	20	23	41	24	0	0.00113	1.000	1.000
35	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GBA3(3), GGT1(9), SHMT1(6), SHMT2(5)	2695334	28	27	26	9	8	1	3	3	13	0	0.741	1.000	1.000
36	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(12), AGT(10), AGTR1(12), BDKRB2(4), KNG1(8), NOS3(21), REN(8)	4146324	75	50	68	13	20	6	11	17	21	0	0.0185	1.000	1.000
37	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(1), CSF1(4), CSF3(2), EPO(1), IL11(6), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), IL9(1)	3217023	47	38	44	13	14	11	4	13	4	1	0.219	1.000	1.000
38	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(4), GALT(3), UGDH(8), UGP2(10), UXS1(8)	2598375	33	30	33	7	8	1	6	8	10	0	0.416	1.000	1.000
39	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(2), CASP3(3), CFL1(2), CFLAR(2), PDE6D(2)	1338956	11	11	11	4	4	0	0	5	2	0	0.758	1.000	1.000
40	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(9), CD4(4), HLA-DRB1(6), IL1B(4), IL4(5), IL5RA(9), IL6(5)	2510259	43	27	40	13	13	6	5	14	3	2	0.392	1.000	1.000
41	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(12), PDXK(1), PDXP(1), PNPO(2), PSAT1(6)	2535314	22	21	21	6	6	7	3	3	3	0	0.298	1.000	1.000
42	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(12), ACO1(11), ACO2(7), ACSS1(6), ACSS2(9), FH(9), IDH2(16), MDH1(8), MDH2(3), SUCLA2(6)	6547981	87	69	80	16	23	16	12	23	13	0	0.00504	1.000	1.000
43	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	2460399	25	23	22	6	10	4	1	7	3	0	0.289	1.000	1.000
44	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(12), RAB11A(3), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(3), RAB6A(4), RAB9A(2)	2211388	37	30	35	11	12	5	8	5	7	0	0.276	1.000	1.000
45	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(6)	1061048	14	13	14	6	8	1	3	0	2	0	0.643	1.000	1.000
46	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(4), GALT(3), UGDH(8), UXS1(8)	2029445	23	22	23	6	6	1	4	5	7	0	0.606	1.000	1.000
47	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(4), IL1B(4), MST1(5), MST1R(14), TNF(1)	2643030	28	25	25	7	9	4	4	8	3	0	0.198	1.000	1.000
48	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(9), PAPSS1(4), PAPSS2(5), SULT1A2(4), SULT1E1(5), SULT2A1(4), SUOX(5)	3569533	36	26	33	7	11	5	4	9	7	0	0.172	1.000	1.000
49	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(7)	910750	11	10	11	6	4	1	2	3	1	0	0.851	1.000	1.000
50	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(7), ACOX1(11), ACOX3(8), ELOVL2(9), ELOVL5(3), ELOVL6(3), FADS2(10), HADHA(10), HSD17B12(3), SCD(4)	5597538	68	53	65	11	22	8	10	17	11	0	0.00393	1.000	1.000
51	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(7), ACAT2(8), OXCT1(3)	1813873	18	16	16	8	2	5	3	4	4	0	0.827	1.000	1.000
52	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(11), KARS(8)	2561211	22	19	21	5	4	1	5	8	4	0	0.429	1.000	1.000
53	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(14), ADORA2A(4), ADORA2B(5), ADORA3(14), LTB4R(1), P2RY1(5), P2RY2(6), P2RY6(5)	2663583	54	44	49	17	22	14	8	7	3	0	0.107	1.000	1.000
54	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8)	2941977	39	35	36	13	5	13	6	13	2	0	0.359	1.000	1.000
55	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(10), BIRC3(11), FADD(1), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	3284246	43	36	33	13	9	15	0	9	10	0	0.370	1.000	1.000
56	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	3	GLS(2), GLS2(6), GLUD1(4)	1771605	12	12	12	4	5	3	0	3	1	0	0.611	1.000	1.000
57	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(13), GBA(4), GBA3(3), LPO(9), MPO(13), PRDX6(4), TPO(29)	4183716	75	58	69	18	37	11	5	11	11	0	0.0736	1.000	1.000
58	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(6), IDI1(4), SQLE(1)	1611811	14	14	14	5	1	2	3	4	4	0	0.715	1.000	1.000
59	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(30), ACACB(37), MCAT(3), OLAH(10), OXSM(10)	6469721	90	56	82	15	28	11	15	19	16	1	0.0105	1.000	1.000
60	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(22), CREM(10), FHL5(8), FSHB(4), FSHR(16), GNAS(35), XPO1(7)	4643789	102	75	80	26	44	27	9	15	7	0	0.0598	1.000	1.000
61	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(5), CDK7(3), MNAT1(3), SHH(3), XPO1(7)	4537450	58	46	56	13	15	11	8	19	5	0	0.0951	1.000	1.000
62	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(11), CLOCK(20), CRY1(13), CRY2(5), CSNK1E(9), PER1(12)	4314594	70	49	50	14	20	11	3	18	17	1	0.173	1.000	1.000
63	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(6), GGPS1(4), IDI1(4), IDI2(3), SQLE(1)	2198213	21	21	20	6	4	2	3	5	7	0	0.562	1.000	1.000
64	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7)	6799094	108	67	101	25	18	22	20	34	13	1	0.0238	1.000	1.000
65	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(12), PARK2(11), SNCA(2), SNCAIP(6), UBE2E2(3), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5)	3325112	45	35	44	13	13	2	9	14	7	0	0.286	1.000	1.000
66	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4)	6833745	109	79	95	28	28	28	16	26	11	0	0.0373	1.000	1.000
67	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	IL13(2), IL4(5), MAF(9), MAP2K3(8), MAPK14(7), NFATC2(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	4691769	66	55	66	18	29	11	6	12	8	0	0.0738	1.000	1.000
68	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(11), DLL1(6), FURIN(14), PSEN1(3)	2426914	34	27	34	11	11	5	5	7	6	0	0.336	1.000	1.000
69	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(5), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GCNT2(24), ST3GAL6(12), ST8SIA1(10)	6934431	120	82	112	28	40	18	10	34	17	1	0.0354	1.000	1.000
70	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(2), COQ6(2), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1)	2135214	16	16	18	6	6	1	6	1	2	0	0.570	1.000	1.000
71	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(6), MMP2(12), MMP9(14), RECK(12), TIMP1(1), TIMP2(3), TIMP3(10), TIMP4(4)	3887906	66	50	63	19	33	11	5	11	6	0	0.146	1.000	1.000
72	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), KARS(8)	3769147	42	35	39	11	8	5	6	15	8	0	0.433	1.000	1.000
73	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(5), ICAM1(4), ITGAL(18), ITGAM(13), ITGB2(16), SELE(11), SELL(5)	5180842	72	56	73	22	28	12	7	12	13	0	0.248	1.000	1.000
74	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(7), CBS(3), CTH(5), GGT1(9), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), PAPSS1(4), PAPSS2(5), SCLY(11), SEPHS1(5)	6284020	79	58	69	20	24	8	12	15	20	0	0.1000	1.000	1.000
75	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(11), ALAS2(10), CPO(9), FECH(3), GATA1(18), HBB(2), HMBS(4), UROD(2), UROS(5)	4302767	64	46	59	16	19	16	7	13	9	0	0.155	1.000	1.000
76	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(10), CARS2(6), CDO1(3), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), SDS(3), SULT1B1(5), SULT1C2(6), SULT1C4(3), SULT4A1(6)	6472072	85	64	78	21	29	16	11	17	12	0	0.0739	1.000	1.000
77	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(5), DPM2(1), EGR1(11), HRAS(4), KLK2(4), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), NGFR(4), RAF1(13)	3848594	62	48	54	20	26	7	9	11	9	0	0.181	1.000	1.000
78	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), AOC2(12), AOC3(9), ASPA(6), CNDP1(7), DDC(5), HAL(11), HARS(6), HDC(8), HNMT(11), MAOA(5), MAOB(6), PRPS1(8), PRPS2(6)	12704245	205	115	181	40	62	44	29	47	23	0	4.74e-05	1.000	1.000
79	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(7), IFNAR1(7), IFNAR2(3), IFNB1(6), JAK1(20), STAT1(15), STAT2(10), TYK2(5)	5559736	73	56	64	19	21	17	6	18	11	0	0.183	1.000	1.000
80	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(7), ACAA2(2), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AKR1C4(10), AKR1D1(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), SOAT2(4), SRD5A1(2), SRD5A2(2)	12059743	201	114	178	40	51	47	30	50	22	1	8.55e-05	1.000	1.000
81	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(11), PON2(6), PON3(10), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	4334998	68	50	62	20	17	17	7	17	10	0	0.272	1.000	1.000
82	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(11), ACOX3(8), FADS2(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8)	5392445	63	46	60	14	22	11	7	14	9	0	0.0417	1.000	1.000
83	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(10), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHB(5), LDHC(4)	3413585	42	38	37	12	14	10	5	7	6	0	0.336	1.000	1.000
84	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(3), CASP7(3), DFFA(4), DFFB(2), ENDOG(3), GZMB(4), HMGB1(2), HMGB2(2), TOP2A(23), TOP2B(24)	4743669	70	55	59	16	10	13	7	20	20	0	0.427	1.000	1.000
85	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(6), CAT(7), EPX(13), LPO(9), MPO(13), MTHFR(8), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29)	5802832	100	70	89	26	47	13	10	16	14	0	0.0811	1.000	1.000
86	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), RFK(1), TYR(9)	5145819	67	43	60	15	18	18	8	14	8	1	0.0505	1.000	1.000
87	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), RAC1(2), WASF1(3), WASL(16)	4286018	61	44	58	19	17	7	9	18	10	0	0.398	1.000	1.000
88	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(8), GNAQ(10), ITPKA(3), ITPKB(14)	2758937	40	34	39	14	15	7	3	10	5	0	0.502	1.000	1.000
89	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(11), CLOCK(20), CRY1(13), CRY2(5), CSNK1D(14), CSNK1E(9), NPAS2(10), NR1D1(7), PER1(12), PER2(7), PER3(18)	8609520	126	80	100	27	42	26	9	27	21	1	0.0112	1.000	1.000
90	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(13), EIF2AK4(21), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF5(6), GSK3B(16), PPP1CA(2)	5915668	79	63	68	18	14	28	5	13	19	0	0.0963	1.000	1.000
91	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3)	3758496	51	39	49	13	14	6	5	8	18	0	0.230	1.000	1.000
92	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(11), ACO2(7), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2)	6796112	74	53	68	18	23	9	13	19	10	0	0.0429	1.000	1.000
93	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	C9orf47(2), CNR1(10), CNR2(1), DNMT1(20), MTNR1A(2), MTNR1B(11), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2)	5210537	69	49	62	19	29	9	6	13	12	0	0.0412	1.000	1.000
94	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(8), ANKRD1(7), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(8), IL18(3), IL1A(1), IL1R1(6), MYOG(5), NR4A3(7), WDR1(7)	5529734	59	40	59	15	16	12	8	15	8	0	0.161	1.000	1.000
95	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(13), GBA3(3), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TPO(29), TYR(9)	4802549	86	64	79	23	41	15	7	13	10	0	0.0874	1.000	1.000
96	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(5), SEC61A2(4), SRP19(1), SRP54(2), SRP68(10), SRP72(8), SRPR(11)	3979504	41	34	33	10	9	7	5	9	11	0	0.456	1.000	1.000
97	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(4), GSR(5), GSS(8), IL8(5), NFKB1(8), NOX1(4), RELA(9), TNF(1), XDH(19)	5182619	63	50	59	17	13	20	7	9	14	0	0.236	1.000	1.000
98	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(23), BAD(1), BAK1(2), BAX(14), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), CASP8AP2(27), CASP9(5), CES1(13)	5439431	101	64	83	29	20	8	14	22	35	2	0.756	1.000	1.000
99	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(2), CTSD(6), ESR1(20), GREB1(24), HSPB2(2), MTA1(6), MTA3(3), PDZK1(2), TUBA8(4)	4753786	69	48	69	23	26	7	9	13	14	0	0.349	1.000	1.000
100	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(3), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), MECR(4), PPT1(1), PPT2(4)	4419959	46	40	46	14	12	9	5	11	9	0	0.346	1.000	1.000
101	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(2), FH(9), IDH2(16), MDH1(8), OGDH(13), SDHA(12), SUCLA2(6)	4929826	73	61	65	23	22	13	8	16	14	0	0.341	1.000	1.000
102	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), CYCS(1), GPD2(10), NDUFA1(2), SDHA(12), SDHB(3), SDHD(4), UQCRC1(4)	3380932	40	30	40	11	17	2	8	10	3	0	0.304	1.000	1.000
103	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(8), ME1(11), PC(12), PDHA1(7), SLC25A1(1), SLC25A11(2)	4576581	55	49	49	16	17	15	7	9	7	0	0.219	1.000	1.000
104	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(8), ABP1(4), ACADL(4), ACADM(9), ACADSB(7), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), MLYCD(4), SDS(3), SMS(4), UPB1(7)	15047720	262	128	242	61	80	41	40	71	30	0	0.000278	1.000	1.000
105	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(31), GLS(2), GLUD1(4), GOT1(6)	4073816	48	37	44	13	11	13	10	10	4	0	0.199	1.000	1.000
106	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(3), GRB2(9), HBXIP(4), HRAS(4), PTK2B(13), SHC1(13), SOS1(11), SRC(3)	4492123	60	51	50	17	8	14	8	13	16	1	0.515	1.000	1.000
107	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(6), ATP6V0C(1), CAT(7), EPX(13), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29)	5869137	99	70	88	27	49	13	10	13	14	0	0.0757	1.000	1.000
108	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(4), UBE2A(4), UBE2B(3), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(3), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(19)	5278573	63	44	61	20	17	11	5	13	17	0	0.384	1.000	1.000
109	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), IDI1(4), LSS(4), MVD(3), MVK(16), NQO1(1), NQO2(2), PMVK(2), SC5DL(7), SQLE(1)	5433643	59	45	48	17	17	7	7	13	15	0	0.425	1.000	1.000
110	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GGT1(9), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), GSR(5), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH2(16), MGST1(2), MGST2(2), MGST3(1), TXNDC12(1)	9794709	154	95	134	36	32	28	24	40	30	0	0.0120	1.000	1.000
111	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(22), GNAS(35), GNB1(3), PRKACA(1), PRKAR1A(3)	2973232	64	56	47	21	36	16	3	6	3	0	0.287	1.000	1.000
112	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(11), ACO2(7), AFMID(2), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2)	7126627	76	53	70	20	23	9	13	21	10	0	0.0708	1.000	1.000
113	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	133	APC(530), AXIN1(8), AXIN2(24), BTRC(7), CACYBP(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(4), CHD8(35), CREBBP(68), CSNK1A1(3), CSNK1A1L(8), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(13), CTNNB1(99), CTNNBIP1(1), CUL1(16), CXXC4(2), DAAM1(8), DAAM2(15), DKK1(8), DKK2(24), DKK4(5), DVL2(11), DVL3(8), EP300(42), FBXW11(12), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LEF1(9), LRP5(11), LRP6(24), MAP3K7(7), MAPK10(14), MAPK8(11), MAPK9(10), MMP7(8), MYC(5), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NKD1(6), NLK(12), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PORCN(3), PPARD(4), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRICKLE1(18), PRICKLE2(14), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PSEN1(3), RAC1(2), RAC2(1), ROCK1(27), ROCK2(15), RUVBL1(7), SENP2(3), SFRP1(2), SFRP2(8), SFRP4(5), SFRP5(1), SIAH1(2), SKP1(2), SMAD3(17), SMAD4(166), TBL1X(8), TBL1XR1(11), TCF7(12), TCF7L1(7), TP53(326), VANGL1(12), VANGL2(9), WIF1(5), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3)	75409660	2231	361	1693	732	516	525	238	401	423	128	0.0144	1.000	1.000
114	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	192	ABI2(3), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), APC(530), ARAF(10), ARHGEF1(13), ARHGEF12(10), ARHGEF4(8), ARHGEF6(16), ARHGEF7(21), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(2), BAIAP2(6), BCAR1(5), BDKRB1(3), BDKRB2(4), BRAF(111), CD14(6), CDC42(2), CFL1(2), CFL2(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CRKL(5), CSK(3), CYFIP1(15), CYFIP2(10), DIAPH1(7), DIAPH2(24), DIAPH3(17), DOCK1(22), EGF(7), EGFR(104), EZR(3), F2(9), F2R(11), FGD1(18), FGD3(15), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR4(11), FN1(52), GIT1(3), GNA12(6), GNA13(3), GRLF1(18), GSN(4), HRAS(4), IQGAP1(24), IQGAP2(25), IQGAP3(23), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAV(17), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LIMK1(7), LIMK2(11), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MOS(8), MRAS(4), MSN(6), MYH10(15), MYH14(22), MYH9(40), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), NCKAP1(15), NCKAP1L(21), NRAS(34), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PFN2(4), PFN4(6), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PPP1R12B(28), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAF1(13), RDX(13), ROCK1(27), ROCK2(15), RRAS(2), RRAS2(4), SCIN(10), SLC9A1(9), SOS1(11), SOS2(15), SSH1(13), SSH2(16), SSH3(3), TIAM1(34), TIAM2(24), TMSL3(2), VAV1(22), VAV2(18), VCL(9), WAS(4), WASF1(3), WASF2(5), WASL(16)	137724677	3023	357	2400	1077	624	746	385	643	498	127	0.400	1.000	1.000
115	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), BAD(1), BCAR1(5), BCL2(2), BIRC2(5), BIRC3(11), BRAF(111), CAPN2(8), CAV2(4), CAV3(3), CCND1(2), CCND2(3), CCND3(2), CDC42(2), CHAD(9), COL11A1(56), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), CRKL(5), CTNNB1(99), DIAPH1(7), DOCK1(22), EGF(7), EGFR(104), ELK1(4), ERBB2(28), FARP2(12), FIGF(4), FLNA(24), FLNB(36), FLNC(36), FLT1(34), FN1(52), FYN(15), GRB2(9), GRLF1(18), GSK3B(16), HGF(13), HRAS(4), IBSP(6), IGF1(6), IGF1R(17), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAV(17), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), JUN(2), KDR(38), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), MAP2K1(10), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MET(48), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(1), PDGFC(9), PDGFD(11), PDGFRA(56), PDGFRB(20), PDPK1(4), PGF(3), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PRKCA(5), PRKCG(19), PTEN(286), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAF1(13), RAP1A(1), RAP1B(2), RAPGEF1(19), RELN(83), ROCK1(27), ROCK2(15), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SPP1(4), SRC(3), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TLN1(21), TLN2(13), TNC(38), TNN(30), TNR(45), TNXB(51), VASP(4), VAV1(22), VAV2(18), VCL(9), VEGFA(5), VEGFB(3), VEGFC(11), VTN(10), VWF(30), ZYX(2)	179391559	3634	343	3068	1427	875	956	500	810	470	23	0.790	1.000	1.000
116	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(11), APC(530), AR(20), ASAH1(4), BRAF(111), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(8), EGFR(104), GNA11(8), GNA15(5), GNAI1(3), GNAQ(10), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), MAPK10(14), MAPK14(7), PHKA2(15), PIK3CA(288), PIK3CD(10), PIK3R1(53), PITX2(2), PTX3(3), RAF1(13), SRC(3)	26669856	1397	343	934	487	174	436	183	269	220	115	0.153	1.000	1.000
117	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	235	ACVR1C(9), AKT1(11), AKT2(7), AKT3(7), ARRB1(4), ARRB2(1), ATF2(6), ATF4(2), BDNF(4), BRAF(111), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CACNA2D1(28), CACNA2D2(9), CACNA2D3(21), CACNA2D4(12), CACNB1(6), CACNB2(9), CACNB3(2), CACNB4(3), CACNG1(5), CACNG2(5), CACNG3(8), CACNG4(4), CACNG5(8), CACNG6(3), CACNG7(6), CACNG8(2), CASP3(3), CD14(6), CDC25B(11), CDC42(2), CRKL(5), DAXX(14), DDIT3(4), DUSP1(6), DUSP10(5), DUSP16(9), DUSP3(4), DUSP4(6), DUSP5(1), DUSP6(6), DUSP7(6), DUSP9(9), ECSIT(6), EGF(7), EGFR(104), ELK1(4), ELK4(4), FAS(7), FASLG(3), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR4(11), FLNA(24), FLNB(36), FLNC(36), FOS(4), GADD45G(1), GNA12(6), GRB2(9), HRAS(4), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAPT(10), MAX(5), MEF2C(15), MKNK1(2), MKNK2(6), MOS(8), MRAS(4), MYC(5), NF1(118), NFATC2(10), NFATC4(11), NFKB1(8), NFKB2(4), NLK(12), NR4A1(3), NRAS(34), NTF3(3), NTRK1(16), NTRK2(23), PAK1(10), PAK2(14), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PPM1A(8), PPM1B(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PPP5C(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTPN5(7), PTPN7(3), PTPRR(11), RAC1(2), RAC2(1), RAF1(13), RAP1A(1), RAP1B(2), RAPGEF2(29), RASA1(20), RASA2(15), RASGRF1(22), RASGRF2(20), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KA6(15), RRAS(2), RRAS2(4), SOS1(11), SOS2(15), SRF(4), STK3(8), STK4(8), STMN1(1), TAOK1(17), TAOK2(13), TAOK3(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF1A(4), TP53(326), TRAF2(8), TRAF6(4), ZAK(8)	138336764	2773	342	2357	916	784	593	344	606	428	18	0.00305	1.000	1.000
118	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(530), AXIN1(8), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), CTNNB1(99), DVL2(11), DVL3(8), FBXW2(5), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LDLR(9), MAPK10(14), MAPK9(10), MYC(5), PAFAH1B1(6), PLAU(6), PPP2R5C(5), PPP2R5E(8), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), RAC1(2), SFRP4(5), TCF7(12), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4)	27634889	1047	337	765	360	169	275	93	166	228	116	0.256	1.000	1.000
119	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(11), AKT1(11), AKT2(7), AKT3(7), APAF1(23), ATM(200), BAD(1), BAX(14), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CAPN1(2), CAPN2(8), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CFLAR(2), CSF2RB(13), CYCS(1), DFFA(4), DFFB(2), ENDOG(3), FADD(1), FAS(7), FASLG(3), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL3(6), IRAK1(6), IRAK2(11), IRAK3(9), IRAK4(6), MAP3K14(6), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), NTRK1(16), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), RIPK1(7), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFRSF1A(4), TNFSF10(2), TP53(326), TRAF2(8)	40660625	1283	332	896	446	257	397	176	241	201	11	0.178	1.000	1.000
120	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(11), APC(530), AXIN1(8), CCND1(2), CD14(6), CTNNB1(99), FZD1(7), GJA1(5), GNAI1(3), GSK3B(16), IRAK1(6), LBP(7), LEF1(9), LY96(4), MYD88(3), NFKB1(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), RELA(9), TIRAP(5), TLR4(15), TOLLIP(5), WNT1(7)	14743955	1113	331	693	379	90	385	148	166	208	116	0.0123	1.000	1.000
121	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT1(11), AKT2(7), AKT3(7), ANKRD6(12), APC(530), AXIN1(8), AXIN2(24), CER1(4), CSNK1A1(3), CTNNB1(99), DACT1(18), DKK1(8), DKK2(24), DKK3(7), DKK4(5), FSTL1(9), GSK3A(6), GSK3B(16), LRP1(49), MVP(10), NKD1(6), PIN1(2), PSEN1(3), PTPRA(5), SENP2(3), SFRP1(2), TSHB(1), WIF1(5)	19778956	884	331	613	295	115	235	80	139	197	118	0.254	1.000	1.000
122	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(27), ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), ATM(200), ATR(43), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDC14A(10), CDC14B(5), CDC16(5), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(5), CDC26(1), CDC27(16), CDC6(6), CDC7(23), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CHEK1(10), CHEK2(27), CREBBP(68), CUL1(16), DBF4(8), E2F2(7), E2F3(5), EP300(42), ESPL1(22), FZR1(3), GADD45G(1), GSK3B(16), HDAC1(5), HDAC2(8), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTTG1(2), RB1(123), RBL1(18), RBL2(22), SFN(1), SKP1(2), SKP2(3), SMAD3(17), SMAD4(166), SMC1A(21), SMC1B(25), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TP53(326), WEE1(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	69732335	1728	329	1327	555	362	490	183	360	308	25	0.0276	1.000	1.000
123	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(27), ATM(200), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDAN1(7), CDC14A(10), CDC14B(5), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(5), CDC6(6), CDC7(23), CDK2(5), CDK4(3), CDKN1A(2), CDKN2A(7), CHEK1(10), CHEK2(27), DTX4(8), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), EP300(42), ESPL1(22), GSK3B(16), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), HDAC8(3), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MPEG1(6), MPL(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTPRA(5), PTTG1(2), RB1(123), RBL1(18), SKP2(3), SMAD4(166), TBC1D8(11), TFDP1(10), TGFB1(2), TP53(326), WEE1(15)	56016478	1486	327	1111	488	298	448	160	302	256	22	0.0477	1.000	1.000
124	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	218	ADCYAP1R1(4), ADORA1(14), ADORA2A(4), ADORA2B(5), ADORA3(14), ADRA1A(10), ADRA1B(5), ADRA2A(5), ADRA2B(6), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), C5AR1(7), CALCR(8), CALCRL(7), CCKAR(6), CCKBR(12), CGA(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CNR1(10), CNR2(1), CRHR1(4), CRHR2(5), CTSG(4), CYSLTR1(9), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2(9), F2R(11), F2RL1(7), F2RL2(6), FPR1(5), FSHB(4), FSHR(16), GABBR1(16), GABBR2(15), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GABRB1(10), GABRB2(7), GABRB3(14), GABRD(6), GABRE(10), GABRG1(17), GABRG2(15), GABRG3(11), GABRP(9), GABRQ(16), GABRR1(5), GABRR2(8), GALR1(4), GH1(4), GH2(4), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(6), GLP2R(8), GLRA1(10), GLRA2(8), GLRA3(12), GLRB(13), GNRHR(9), GPR156(15), GPR35(3), GPR50(9), GPR63(4), GPR83(6), GRIA1(35), GRIA2(23), GRIA3(11), GRIA4(36), GRID1(28), GRID2(25), GRIK1(13), GRIK2(43), GRIK3(28), GRIK4(20), GRIK5(14), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRIN3A(16), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM6(24), GRM7(30), GRM8(27), GRPR(4), GZMA(8), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HRH4(6), HTR1A(15), HTR1B(11), HTR1D(4), HTR1E(15), HTR1F(9), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LEP(1), LEPR(15), LHB(3), LHCGR(27), LTB4R(1), MAS1(2), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), MCHR1(8), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPBWR1(5), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(6), NPY2R(12), NPY5R(5), NR3C1(8), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), P2RY1(5), P2RY10(12), P2RY14(9), P2RY2(6), P2RY4(8), P2RY6(5), PARD3(11), PPYR1(5), PRL(3), PRLHR(5), PRLR(8), PRSS1(6), PRSS3(6), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTH2R(14), RXFP1(6), RXFP2(18), SCTR(5), SSTR1(11), SSTR2(4), SSTR4(12), TAAR1(6), TAAR2(6), TAAR5(8), TAAR6(4), TAAR8(5), TAAR9(6), TACR1(9), TACR2(4), TACR3(11), THRA(6), THRB(14), TRHR(7), TRPV1(9), TSHB(1), TSPO(1), VIPR1(6), VIPR2(11)	105070997	2078	326	1901	775	720	377	237	483	257	4	0.188	1.000	1.000
125	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	164	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY7(10), ADCY8(30), ADCY9(19), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), ATP2A1(23), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), ATP2B4(21), AVPR1A(13), AVPR1B(5), BDKRB1(3), BDKRB2(4), BST1(2), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CCKAR(6), CCKBR(12), CD38(4), CHRM1(4), CHRM2(25), CHRM3(21), CHRM5(5), CYSLTR1(9), DRD1(9), EDNRA(8), EDNRB(13), EGFR(104), ERBB2(28), ERBB3(28), ERBB4(56), F2R(11), GNA11(8), GNA14(10), GNA15(5), GNAL(4), GNAQ(10), GNAS(35), GRIN1(5), GRIN2A(48), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), GRPR(4), HRH1(4), HRH2(15), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), LHCGR(27), MYLK(29), MYLK2(9), NOS1(23), NOS3(21), NTSR1(5), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), PDE1A(8), PDE1B(10), PDE1C(17), PDGFRA(56), PDGFRB(20), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PPID(4), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTAFR(1), PTGFR(7), PTK2B(13), RYR1(58), RYR2(122), RYR3(82), SLC25A4(4), SLC25A5(8), SLC8A1(22), SLC8A2(14), SLC8A3(13), SPHK1(2), SPHK2(5), TACR1(9), TACR2(4), TACR3(11), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(15), VDAC1(6), VDAC2(4), VDAC3(2)	131313206	2412	325	2256	897	836	466	270	506	324	10	0.428	1.000	1.000
126	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(530), AXIN1(8), CREBBP(68), CTNNB1(99), EP300(42), FZD1(7), GSK3B(16), HDAC1(5), LDB1(7), LEF1(9), PITX2(2), TRRAP(61), WNT1(7)	16638155	861	324	590	301	92	251	86	126	190	116	0.173	1.000	1.000
127	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	28	ACVR1(6), APC(530), ATF2(6), AXIN1(8), BMP10(13), BMP2(8), BMP4(5), BMP5(8), BMP7(14), CHRD(14), CTNNB1(99), FZD1(7), GATA4(4), GSK3B(16), MAP3K7(7), MEF2C(15), MYL2(2), NPPA(1), NPPB(4), RFC1(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14), WNT1(7)	16197305	859	323	591	287	105	223	81	146	188	116	0.0947	1.000	1.000
128	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(2), AKT1(11), APC(530), ASAH1(4), CAMP(1), CAV3(3), DAG1(8), DLG4(10), EPHB2(15), GNAI1(3), GNAQ(10), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(4), RYR1(58)	23036985	818	322	601	287	135	182	83	126	176	116	0.354	1.000	1.000
129	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(530), AXIN1(8), BTRC(7), CCND1(2), CREBBP(68), CSNK1A1(3), CSNK1D(14), CSNK2A1(7), CTBP1(5), CTNNB1(99), FZD1(7), GSK3B(16), HDAC1(5), MAP3K7(7), MYC(5), NLK(12), PPARD(4), PPP2CA(3), TLE1(7), WIF1(5), WNT1(7)	14349769	821	322	556	285	72	226	88	131	188	116	0.181	1.000	1.000
130	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(23), ATM(200), ATR(43), BAI1(11), BAX(14), BID(2), CASP3(3), CASP9(5), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG1(4), CCNG2(4), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN2A(7), CHEK1(10), CHEK2(27), CYCS(1), EI24(1), FAS(7), GADD45G(1), GTSE1(2), IGF1(6), IGFBP3(6), MDM2(11), MDM4(6), PPM1D(6), PTEN(286), RCHY1(4), RFWD2(5), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(3), SERPINE1(8), SESN1(5), SESN2(8), SESN3(7), SFN(1), SIAH1(2), STEAP3(6), THBS1(12), TNFRSF10B(4), TP53(326), TP73(5), TSC2(15), ZMAT3(9)	31160217	1174	321	823	406	199	399	130	224	200	22	0.209	1.000	1.000
131	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(200), CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CREB3(5), CREB3L1(5), CREB3L3(4), CREB3L4(4), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), GBA2(15), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MNAT1(3), MYC(5), MYT1(20), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLE(37), POLE2(5), PRIM1(5), RB1(123), RBL1(18), RPA1(12), RPA2(1), RPA3(4), TFDP1(10), TFDP2(4), TNXB(51), TP53(326), WEE1(15)	36834308	1069	317	811	334	233	287	120	228	182	19	0.00650	1.000	1.000
132	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(530), CREBBP(68), EP300(42), MAP2K1(10), MAP3K7(7), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24)	12753398	718	316	486	247	77	195	67	95	169	115	0.154	1.000	1.000
133	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	133	ACTB(4), ACTG1(6), CHAD(9), COL11A1(56), COL11A2(17), COL17A1(13), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), DES(5), DSC1(12), DSC2(16), DSC3(12), DSG1(19), DSG2(11), DSG3(17), DSG4(24), FN1(52), GJA1(5), GJA10(12), GJA3(4), GJA4(3), GJA5(7), GJA8(19), GJA9(5), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GJB7(3), GJC1(9), GJC3(3), GJD2(4), GJD4(4), IBSP(6), INA(8), ITGA6(14), ITGB4(16), KRT1(18), KRT10(7), KRT12(6), KRT13(11), KRT14(8), KRT15(8), KRT16(5), KRT17(10), KRT18(3), KRT19(4), KRT2(14), KRT20(2), KRT23(9), KRT24(2), KRT25(12), KRT27(2), KRT28(5), KRT3(10), KRT31(12), KRT32(6), KRT33A(8), KRT33B(5), KRT34(11), KRT35(5), KRT36(5), KRT37(8), KRT38(1), KRT39(9), KRT40(2), KRT5(7), KRT6A(7), KRT6B(6), KRT6C(6), KRT7(4), KRT71(9), KRT72(14), KRT73(10), KRT74(7), KRT75(13), KRT76(9), KRT77(6), KRT78(5), KRT79(7), KRT8(4), KRT81(2), KRT82(5), KRT83(3), KRT84(8), KRT85(12), KRT86(4), KRT9(12), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), LMNB1(9), LMNB2(2), NES(28), PRPH(2), RELN(83), SPP1(4), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VIM(7), VTN(10), VWF(30)	120454896	1922	315	1806	737	667	291	275	420	265	4	0.550	1.000	1.000
134	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	23	APC(530), ASAH1(4), CAMP(1), CASP3(3), CERK(3), CREB1(3), CREB3(5), CREB5(5), DAG1(8), EPHB2(15), FOS(4), GNAQ(10), ITPKA(3), ITPKB(14), JUN(2), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10)	13029704	696	313	478	223	59	172	67	110	172	116	0.0499	1.000	1.000
135	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(11), APC(530), AXIN1(8), BTRC(7), CTNNB1(99), DLL1(6), FZD1(7), GSK3B(16), PSEN1(3), WNT1(7)	8223156	694	312	441	230	38	199	64	108	169	116	0.0477	1.000	1.000
136	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(200), ATR(43), BRCA1(29), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(10), CHEK2(27), EP300(42), MDM2(11), MYT1(20), PRKDC(80), RPS6KA1(9), TP53(326), WEE1(15), YWHAH(3), YWHAQ(1)	21809237	856	304	608	285	180	252	92	161	157	14	0.142	1.000	1.000
137	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	CD36(3), CD44(5), CD47(8), CHAD(9), COL11A1(56), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), DAG1(8), FN1(52), FNDC1(37), FNDC3A(13), FNDC4(6), FNDC5(2), GP5(8), GP6(11), GP9(1), HMMR(15), HSPG2(26), IBSP(6), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAV(17), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), RELN(83), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SPP1(4), SV2A(22), SV2B(9), SV2C(13), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VTN(10), VWF(30)	108739386	1683	302	1592	668	562	250	236	383	245	7	0.755	1.000	1.000
138	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(27), ABL2(17), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), BRAF(111), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CBL(38), CBLB(14), CBLC(3), CDKN1A(2), CDKN1B(4), CRKL(5), EGF(7), EGFR(104), ELK1(4), ERBB2(28), ERBB3(28), ERBB4(56), EREG(3), GAB1(15), GRB2(9), GSK3B(16), HBEGF(1), HRAS(4), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MYC(5), NCK2(4), NRAS(34), NRG1(26), NRG2(6), NRG3(14), NRG4(2), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), RAF1(13), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SRC(3), STAT5A(8), STAT5B(19)	51806270	1411	301	1063	515	250	432	233	309	185	2	0.457	1.000	1.000
139	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(27), ATM(200), ATR(43), CCNA1(16), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), DHFR(1), GSK3B(16), HDAC1(5), RB1(123), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TP53(326)	15692159	823	300	571	265	175	250	77	151	149	21	0.0342	1.000	1.000
140	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(27), CDKN2A(7), MDM2(11), MYC(5), PIK3CA(288), PIK3R1(53), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), RAC1(2), RB1(123), TP53(326), TWIST1(3)	9931204	881	299	530	269	158	318	137	142	114	12	0.000210	1.000	1.000
141	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(200), ATR(43), BRCA1(29), BRCA2(77), CHEK1(10), CHEK2(27), FANCA(9), FANCC(8), FANCE(4), FANCF(3), FANCG(5), HUS1(7), MRE11A(15), RAD1(2), RAD17(7), RAD50(23), RAD9A(1), TP53(326), TREX1(3)	21843629	799	299	545	275	149	238	78	156	164	14	0.452	1.000	1.000
142	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CDK2(5), CDK4(3), CHEK1(10), MYT1(20), RB1(123), TP53(326), WEE1(15), YWHAH(3)	9429664	732	299	488	212	156	231	68	137	122	18	0.00330	1.000	1.000
143	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(11), APAF1(23), ATM(200), BAD(1), BAX(14), BCL2(2), BCL2L1(1), BID(2), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CYCS(1), EIF2S1(3), PRKCA(5), PTK2(24), PXN(2), STAT1(15), TLN1(21), TP53(326)	14393124	664	296	453	219	148	186	71	122	125	12	0.203	1.000	1.000
144	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	125	ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), AMOTL1(15), ASH1L(51), CASK(9), CDC42(2), CDK4(3), CGN(15), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNNB1(99), CTTN(4), EPB41(11), EPB41L1(13), EPB41L2(12), EPB41L3(31), EXOC3(3), EXOC4(19), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), HCLS1(15), HRAS(4), IGSF5(14), INADL(15), JAM2(2), JAM3(9), LLGL1(6), LLGL2(6), MAGI1(27), MAGI2(25), MAGI3(8), MLLT4(17), MPDZ(23), MPP5(6), MRAS(4), MYH1(38), MYH10(15), MYH11(40), MYH13(26), MYH14(22), MYH15(31), MYH2(37), MYH3(39), MYH4(28), MYH6(27), MYH7(24), MYH7B(27), MYH8(42), MYH9(40), MYL2(2), MYL7(1), NRAS(34), OCLN(2), PARD3(11), PARD6A(1), PARD6B(2), PARD6G(6), PPM1J(3), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP2R3A(14), PPP2R4(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PTEN(286), RAB13(1), RAB3B(3), RRAS(2), RRAS2(4), SPTAN1(25), SRC(3), SYMPK(11), TJAP1(3), TJP1(21), TJP2(17), TJP3(11), VAPA(2), YES1(9), ZAK(8)	96745153	1780	295	1516	623	491	442	226	366	238	17	0.246	1.000	1.000
145	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	54	ALG2(8), BAK1(2), BAX(14), BFAR(8), BTK(11), CAD(20), CASP10(7), CASP3(3), CASP8AP2(27), CD7(4), CSNK1A1(3), DAXX(14), DEDD(2), DEDD2(1), DFFA(4), DIABLO(3), EGFR(104), EPHB2(15), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(5), MAP2K4(32), MAP3K1(18), MAP3K5(14), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MET(48), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PFN2(4), PTPN13(20), RALBP1(6), RIPK1(7), ROCK1(27), SMPD1(9), TP53(326), TPX2(9), TRAF2(8), TUFM(6)	34232088	890	295	681	265	209	231	106	191	141	12	0.00386	1.000	1.000
146	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	124	ACACA(30), ACACB(37), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), BRAF(111), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBL(38), CBLB(14), CBLC(3), CRKL(5), ELK1(4), EXOC7(3), FBP1(1), FBP2(4), FLOT1(6), FLOT2(2), FOXO1(8), G6PC(4), G6PC2(2), GCK(3), GRB2(9), GSK3B(16), GYS1(5), GYS2(13), HRAS(4), IKBKB(7), INPP5D(8), INSR(20), IRS1(17), IRS4(30), LIPE(9), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MKNK1(2), MKNK2(6), NRAS(34), PCK1(3), PCK2(6), PDE3A(19), PDE3B(8), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PKLR(11), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R3A(38), PPP1R3B(4), PPP1R3C(4), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCI(24), PRKCZ(3), PRKX(3), PTPN1(10), PTPRF(21), PYGB(15), PYGL(6), PYGM(10), RAF1(13), RAPGEF1(19), RHEB(4), RHOQ(6), RPS6(2), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SLC2A4(7), SOCS2(2), SORBS1(11), SOS1(11), SOS2(15), SREBF1(8), TRIP10(4), TSC1(17), TSC2(15)	76896447	1492	294	1168	527	343	384	230	343	190	2	0.163	1.000	1.000
147	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(23), ATM(200), BAX(14), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDKN1A(2), MDM2(11), PCNA(2), RB1(123), TIMP3(10), TP53(326)	9603978	729	294	478	222	146	226	67	138	133	19	0.0182	1.000	1.000
148	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(29), AKT1(11), ATM(200), BAX(14), CDKN1A(2), CPB2(10), CSNK1A1(3), CSNK1D(14), FHL2(2), HIF1A(14), IGFBP3(6), MAPK8(11), MDM2(11), NFKBIB(5), NQO1(1), TP53(326)	10342756	659	293	449	189	141	187	70	128	122	11	0.00986	1.000	1.000
149	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(27), ATM(200), BRCA1(29), CDKN1A(2), CHEK1(10), CHEK2(27), JUN(2), MAPK8(11), MDM2(11), MRE11A(15), NFKB1(8), NFKBIA(1), RAD50(23), RBBP8(14), RELA(9), TP53(326), TP73(5)	15249721	720	292	488	255	150	222	69	128	140	11	0.585	1.000	1.000
150	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	143	AKT1(11), AKT2(7), AKT3(7), BCL2L1(1), CBL(38), CBLB(14), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(68), CSF2RB(13), CSF3(2), CSF3R(18), EP300(42), EPO(1), EPOR(2), GH1(4), GH2(4), GHR(12), GRB2(9), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL13RA2(15), IL15(1), IL15RA(1), IL19(2), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL9(1), IRF9(6), JAK1(20), JAK2(48), JAK3(27), LEP(1), LEPR(15), LIF(1), LIFR(35), MPL(5), MYC(5), OSM(4), OSMR(20), PIAS1(4), PIAS2(4), PIAS3(10), PIAS4(2), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIM1(3), PRL(3), PRLR(8), PTPN11(31), PTPN6(4), SOCS2(2), SOCS5(10), SOCS7(1), SOS1(11), SOS2(15), SPRED1(9), SPRED2(9), SPRY1(9), SPRY2(2), SPRY4(7), STAM(3), STAM2(4), STAT1(15), STAT2(10), STAT3(10), STAT4(10), STAT5A(8), STAT5B(19), STAT6(4), TPO(29), TSLP(3), TYK2(5)	72684316	1420	291	1139	495	295	406	218	318	179	4	0.131	1.000	1.000
151	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	234	ACVR1(6), ACVR2B(12), AMHR2(4), BMP2(8), BMP7(14), BMPR1B(14), CCL11(1), CCL13(1), CCL14(4), CCL15(2), CCL16(2), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL28(4), CCL4(1), CCL7(2), CCL8(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CD27(4), CD40(6), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(4), CSF1R(15), CSF2RB(13), CSF3(2), CSF3R(18), CX3CL1(4), CX3CR1(5), CXCL1(1), CXCL10(1), CXCL11(3), CXCL12(2), CXCL14(1), CXCL16(2), CXCL5(5), CXCL6(1), CXCL9(6), CXCR3(4), CXCR4(6), CXCR6(1), EDA(2), EDA2R(4), EDAR(6), EGF(7), EGFR(104), EPO(1), EPOR(2), FAS(7), FASLG(3), FLT1(34), FLT3(27), FLT3LG(1), FLT4(16), GDF5(11), GH1(4), GH2(4), GHR(12), HGF(13), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL15(1), IL15RA(1), IL17A(2), IL17B(1), IL17RA(7), IL17RB(8), IL18(3), IL18R1(13), IL18RAP(10), IL19(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL1RAP(5), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL25(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL8(5), IL9(1), INHBA(17), INHBB(3), INHBC(3), INHBE(2), KDR(38), KIT(139), KITLG(3), LEP(1), LEPR(15), LIF(1), LIFR(35), LTA(1), LTBR(4), MET(48), MPL(5), NGFR(4), OSM(4), OSMR(20), PDGFB(1), PDGFC(9), PDGFRA(56), PDGFRB(20), PF4(3), PLEKHO2(7), PPBP(6), PRL(3), PRLR(8), RELT(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(5), TNFRSF11B(5), TNFRSF13B(6), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFRSF8(7), TNFRSF9(9), TNFSF10(2), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(3), TNFSF14(3), TNFSF15(3), TNFSF4(4), TNFSF8(4), TPO(29), TSLP(3), VEGFA(5), VEGFB(3), VEGFC(11), XCL1(1), XCL2(3), XCR1(5)	85879835	1562	290	1398	559	390	395	197	375	200	5	0.184	1.000	1.000
152	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(11), ATF2(6), CDC42(2), DLD(3), DUSP10(5), DUSP4(6), GAB1(15), GCK(3), IL1R1(6), JUN(2), MAP2K4(32), MAP2K5(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK10(14), MAPK7(6), MAPK8(11), MAPK9(10), MYEF2(14), NFATC3(13), NR2C2(11), PAPPA(33), SHC1(13), TP53(326), TRAF6(4), ZAK(8)	25167958	723	290	533	179	193	141	96	143	143	7	3.23e-05	1.000	1.000
153	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(27), ACTN1(9), ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGEF6(16), ARHGEF7(21), BCAR1(5), BRAF(111), CDC42(2), CDKN2A(7), CSE1L(10), DOCK1(22), EPHB2(15), FYN(15), GRB2(9), GRB7(3), GRLF1(18), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB3BP(1), MAP2K4(32), MAP3K11(11), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MRAS(4), MYLK(29), MYLK2(9), P4HB(6), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CA(288), PIK3CB(5), PKLR(11), PLCG1(17), PLCG2(23), PTEN(286), PTK2(24), RAF1(13), RALA(7), RHO(4), ROCK1(27), ROCK2(15), SHC1(13), SOS1(11), SOS2(15), SRC(3), TERF2IP(3), TLN1(21), TLN2(13), VASP(4), WAS(4), ZYX(2)	60981397	1515	289	1137	564	242	483	225	339	210	16	0.598	1.000	1.000
154	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(200), ATR(43), CDC25C(5), CHEK1(10), CHEK2(27), TP53(326), YWHAH(3)	8629341	614	287	394	191	130	184	61	109	117	13	0.127	1.000	1.000
155	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(11), AKT2(7), AKT3(7), BCL10(8), CARD11(50), CBL(38), CBLB(14), CBLC(3), CD247(3), CD28(4), CD3D(4), CD3E(2), CD4(4), CD40LG(10), CD8A(1), CD8B(4), CDC42(2), CDK4(3), CTLA4(4), FOS(4), FYN(15), GRAP2(3), GRB2(9), HRAS(4), ICOS(2), IFNG(3), IKBKB(7), IKBKG(2), IL10(1), IL2(4), IL4(5), ITK(21), JUN(2), LAT(2), LCK(8), LCP2(9), MALT1(12), MAP3K14(6), MAP3K8(4), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NRAS(34), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDCD1(2), PDK1(5), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCQ(15), PTPN6(4), PTPRC(27), RASGRP1(7), SOS1(11), SOS2(15), TEC(8), TNF(1), VAV1(22), VAV2(18), ZAP70(12)	48361787	1062	285	812	380	213	325	175	206	143	0	0.181	1.000	1.000
156	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(11), BCL2(2), EGFR(104), IGF1R(17), MYC(5), POLR2A(12), PPP2CA(3), PRKCA(5), RB1(123), TEP1(29), TERF1(5), TERT(8), TNKS(10), TP53(326), XRCC5(11)	14455283	671	285	462	206	162	196	78	117	106	12	0.00468	1.000	1.000
157	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(23), BAD(1), BAK1(2), BAX(14), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), BIRC2(5), BIRC3(11), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP9(5), CYCS(1), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), GZMB(4), HELLS(12), IKBKB(7), IKBKG(2), IRF1(5), IRF2(10), IRF3(2), IRF4(3), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP2K4(32), MAP3K1(18), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), NFKBIB(5), NFKBIE(4), PLEKHG5(8), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFSF10(2), TP53(326), TP73(5), TRAF1(5), TRAF2(8), TRAF3(10)	26895262	694	284	509	197	176	148	85	135	144	6	0.00579	1.000	1.000
158	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(18), ATP1B1(4), ATP1B2(2), ATP1B3(4), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1S(29), CACNB1(6), CACNB3(2), CALM2(1), CALM3(1), CALR(1), CAMK1(7), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CASQ1(4), CASQ2(8), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), GJA1(5), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), ITPR1(41), ITPR2(41), ITPR3(39), KCNB1(19), KCNJ3(11), KCNJ5(10), MIB1(8), NME7(6), PEA15(1), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SLC8A3(13), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1)	93224411	1520	284	1463	567	564	245	172	309	222	8	0.370	1.000	1.000
159	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	115	ARAF(10), BID(2), BRAF(111), CASP3(3), CD244(7), CD247(3), CD48(2), FAS(7), FASLG(3), FCGR3A(4), FCGR3B(2), FYN(15), GRB2(9), GZMB(4), HCST(2), HLA-C(13), HLA-E(4), HRAS(4), ICAM1(4), ICAM2(5), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), ITGAL(18), ITGB2(16), KIR2DL1(9), KIR2DL4(5), KIR3DL1(6), KIR3DL2(6), KLRC1(2), KLRC2(2), KLRC3(7), KLRD1(3), KLRK1(7), LAT(2), LCK(8), LCP2(9), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MICB(1), NCR1(2), NCR2(2), NCR3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NRAS(34), PAK1(10), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRF1(7), PRKCA(5), PRKCG(19), PTK2B(13), PTPN11(31), PTPN6(4), RAC1(2), RAC2(1), RAF1(13), SH2D1A(3), SH2D1B(1), SH3BP2(6), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SYK(5), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(2), ULBP1(7), ULBP2(2), ULBP3(5), VAV1(22), VAV2(18), ZAP70(12)	53702159	1211	284	891	435	241	344	186	275	163	2	0.336	1.000	1.000
160	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRB1(2), CSNK1D(14), DRD1(9), DRD2(7), EGF(7), EGFR(104), GJA1(5), GJD2(4), GNA11(8), GNAI1(3), GNAI2(2), GNAI3(2), GNAQ(10), GNAS(35), GRB2(9), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), HTR2A(19), HTR2B(7), HTR2C(13), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K1(10), MAP2K2(2), MAP2K5(4), MAP3K2(8), MAPK1(3), MAPK3(3), MAPK7(6), NPR1(16), NPR2(15), NRAS(34), PDGFA(2), PDGFB(1), PDGFC(9), PDGFD(11), PDGFRA(56), PDGFRB(20), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), PRKX(3), RAF1(13), SOS1(11), SOS2(15), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9)	65753685	1220	283	1092	458	387	260	170	270	131	2	0.366	1.000	1.000
161	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(68), DAXX(14), HRAS(4), PAX3(23), PML(11), RARA(5), RB1(123), SIRT1(7), SP100(14), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TP53(326)	9457098	601	283	401	178	152	172	62	101	102	12	0.00278	1.000	1.000
162	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS1(13), CDS2(9), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5D(8), INPP5E(3), INPPL1(14), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), OCRL(16), PI4KA(24), PI4KB(5), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3C3(25), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PRKCA(5), PRKCG(19), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14)	61920237	1442	281	1117	525	297	474	204	274	184	9	0.526	1.000	1.000
163	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA1(12), ACTA2(3), ACTN2(15), ACTN3(6), ACTN4(7), DES(5), DMD(72), FAM48A(9), MYBPC1(9), MYBPC2(16), MYBPC3(14), MYH3(39), MYH6(27), MYH7(24), MYH8(42), MYL2(2), MYL3(1), MYL4(3), MYOM1(27), NEB(98), TMOD1(7), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(2), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(7), TPM3(6), TPM4(8), TTN(727), VIM(7)	62658794	1216	281	1102	363	344	252	163	339	100	18	0.000524	1.000	1.000
164	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	121	ABL1(27), ABLIM1(8), ABLIM2(7), ABLIM3(15), ARHGEF12(10), CDC42(2), CDK5(2), CFL1(2), CFL2(2), CXCL12(2), CXCR4(6), DCC(36), DPYSL2(9), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(3), EFNB1(6), EFNB3(9), EPHA1(7), EPHA2(12), EPHA3(61), EPHA4(20), EPHA5(39), EPHA6(25), EPHA7(38), EPHA8(16), EPHB1(33), EPHB2(15), EPHB3(12), EPHB4(11), EPHB6(12), FES(6), FYN(15), GNAI1(3), GNAI2(2), GNAI3(2), GSK3B(16), HRAS(4), ITGB1(12), L1CAM(14), LIMK1(7), LIMK2(11), LRRC4C(14), MAPK1(3), MAPK3(3), MET(48), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NGEF(17), NRAS(34), NRP1(11), NTN1(4), NTN4(7), NTNG1(14), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLXNA1(20), PLXNA2(21), PLXNA3(22), PLXNB1(20), PLXNB2(26), PLXNB3(22), PLXNC1(18), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RASA1(20), RGS3(22), RND1(3), ROBO1(30), ROBO3(10), ROCK1(27), ROCK2(15), SEMA3A(17), SEMA3B(7), SEMA3C(17), SEMA3D(22), SEMA3E(17), SEMA3F(12), SEMA3G(8), SEMA4A(12), SEMA4B(3), SEMA4C(5), SEMA4D(17), SEMA4F(9), SEMA4G(9), SEMA5A(19), SEMA5B(22), SEMA6A(8), SEMA6B(6), SEMA6C(11), SEMA6D(11), SEMA7A(2), SLIT1(28), SLIT2(29), SLIT3(23), SRGAP1(23), SRGAP2(9), SRGAP3(19), UNC5A(6), UNC5B(8), UNC5C(13), UNC5D(21)	91346636	1565	279	1430	588	492	301	184	339	241	8	0.754	1.000	1.000
165	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	69	ACP1(5), ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ACVR1C(9), BAIAP2(6), CDC42(2), CREBBP(68), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNNB1(99), CTNND1(19), EGFR(104), EP300(42), ERBB2(28), FARP2(12), FER(15), FGFR1(20), FYN(15), IGF1R(17), INSR(20), IQGAP1(24), LEF1(9), LMO7(31), MAP3K7(7), MAPK1(3), MAPK3(3), MET(48), MLLT4(17), NLK(12), PARD3(11), PTPN1(10), PTPN6(4), PTPRB(19), PTPRF(21), PTPRJ(15), PTPRM(38), PVRL1(7), PVRL2(4), PVRL3(4), PVRL4(10), RAC1(2), RAC2(1), SMAD3(17), SMAD4(166), SNAI1(5), SNAI2(10), SORBS1(11), SRC(3), SSX2IP(8), TCF7(12), TCF7L1(7), TGFBR1(17), TGFBR2(24), TJP1(21), VCL(9), WAS(4), WASF1(3), WASF2(5), WASF3(14), WASL(16), YES1(9)	58207715	1292	279	1094	462	304	358	160	285	181	4	0.271	1.000	1.000
166	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(23), BAK1(2), BAX(14), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CYCS(1), FADD(1), FAS(7), FASLG(3), GZMB(4), IKBKG(2), JUN(2), MAP2K4(32), MAP3K1(18), MAP3K14(6), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), PARP1(16), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(2), TP53(326), TRAF1(5), TRAF2(8)	18199757	582	278	407	157	150	130	72	106	118	6	0.000500	1.000	1.000
167	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2L1(1), CDC42(2), CDK2(5), CDKN1B(4), CDKN2A(7), CREB1(3), CREB3(5), CREB5(5), EBP(5), ERBB4(56), F2RL2(6), GAB1(15), GRB2(9), GSK3A(6), GSK3B(16), IGF1(6), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), MET(48), MYC(5), NOLC1(8), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARD3(11), PARD6A(1), PDK1(5), PIK3CA(288), PIK3CD(10), PPP1R13B(9), PREX1(22), PTEN(286), PTK2(24), PTPN1(10), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SLC2A4(7), SOS1(11), SOS2(15), TSC1(17), TSC2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	37417676	1186	276	866	444	175	438	191	225	148	9	0.499	1.000	1.000
168	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(12), ACTA2(3), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADM(5), ARRB1(4), ARRB2(1), ATF1(5), ATF2(6), ATF3(1), ATF4(2), ATF5(2), ATP2A2(16), ATP2A3(11), CACNB3(2), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CNN1(4), CNN2(3), CORIN(18), CREB3(5), CRHR1(4), DGKZ(8), ETS2(4), FOS(4), GABPA(13), GABPB2(3), GBA2(15), GJA1(5), GNAQ(10), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), GSTO1(1), GUCA2B(3), GUCY1A3(25), IGFBP1(2), IGFBP2(3), IGFBP3(6), IGFBP4(4), IGFBP6(2), IL1B(4), IL6(5), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), MIB1(8), MYL2(2), MYL4(3), MYLK2(9), NFKB1(8), NOS1(23), NOS3(21), OXTR(2), PDE4B(9), PDE4D(7), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PLCD1(9), PLCG1(17), PLCG2(23), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RAMP1(2), RAMP2(2), RAMP3(6), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RLN1(3), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SP1(6), TNXB(51), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1)	83365258	1358	275	1310	473	471	215	171	291	204	6	0.0904	1.000	1.000
169	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	101	ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), BCAR1(5), CDC42(2), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNNB1(99), CTNND1(19), CXCL12(2), CXCR4(6), CYBB(4), ESAM(6), EZR(3), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), GRLF1(18), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), ITK(21), JAM2(2), JAM3(9), MAPK12(4), MAPK13(4), MAPK14(7), MLLT4(17), MMP2(12), MMP9(14), MSN(6), MYL2(2), MYL7(1), NCF1(4), NCF2(8), NCF4(4), NOX1(4), NOX3(11), OCLN(2), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(12), RASSF5(6), RHOH(4), ROCK1(27), ROCK2(15), SIPA1(9), TXK(10), VASP(4), VAV1(22), VAV2(18), VCAM1(12), VCL(9)	58620492	1263	274	1010	486	291	349	173	272	173	5	0.879	1.000	1.000
170	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(6), IFNG(3), IFNGR1(6), IFNGR2(4), IKBKB(7), JAK2(48), LIN7A(7), NFKB1(8), NFKBIA(1), RB1(123), RELA(9), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TP53(326), USH1C(11), WT1(28)	9288951	593	270	387	171	135	187	59	104	93	15	0.00182	1.000	1.000
171	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT1(11), AKT2(7), AKT3(7), BTK(11), FCER1A(5), FYN(15), GAB2(9), GRB2(9), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(8), LAT(2), LCP2(9), LYN(13), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MS4A2(3), NRAS(34), PDK1(5), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PRKCA(5), PRKCD(15), PRKCE(4), RAC1(2), RAC2(1), RAF1(13), SOS1(11), SOS2(15), SYK(5), TNF(1), VAV1(22), VAV2(18)	34633041	866	269	646	305	176	270	156	175	88	1	0.153	1.000	1.000
172	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), CREB3(5), CREB3L1(5), CREB3L2(4), CREB3L3(4), CREB3L4(4), CREBBP(68), CTNNB1(99), DCT(17), DVL2(11), DVL3(8), EDN1(3), EDNRB(13), EP300(42), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAS(35), GSK3B(16), HRAS(4), KIT(139), KITLG(3), LEF1(9), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MC1R(2), MITF(14), NRAS(34), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), POMC(4), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), RAF1(13), TCF7(12), TCF7L1(7), TYR(9), TYRP1(6), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3)	51653150	1117	269	964	444	352	281	141	217	126	0	0.748	1.000	1.000
173	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGAP1(3), ARHGAP4(7), ARHGEF11(20), BTK(11), CDC42(2), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(14), ITPR1(41), ITPR2(41), ITPR3(39), LIMK1(7), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3CG(36), PIK3R1(53), PITX2(2), PPP1R13B(9), PTEN(286), RACGAP1(5), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), SAG(5), WASF1(3), WASL(16)	35039117	1109	269	809	417	164	405	169	219	140	12	0.694	1.000	1.000
174	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	77	ACVR1(6), ACVRL1(7), AKT1(11), AURKB(6), BUB1(13), CDKL1(3), CDKL2(16), CDS1(13), CDS2(9), CLK1(8), CLK2(3), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MAP3K10(10), MOS(8), NEK1(20), NEK3(9), OCRL(16), PAK4(6), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CA(288), PIK3CB(5), PIK3CG(36), PIM2(1), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23), PLK3(3), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKG1(12), RAF1(13), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KB1(9), STK11(36), TGFBR1(17), VRK1(6)	54087803	1119	268	879	401	277	303	177	217	143	2	0.388	1.000	1.000
175	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	AKT1(11), AKT2(7), AKT3(7), BCL10(8), BLNK(1), BTK(11), CARD11(50), CD19(10), CD22(15), CD72(3), CD79A(6), CD79B(2), CR2(20), FCGR2B(2), FOS(4), GSK3B(16), HRAS(4), IFITM1(2), IKBKB(7), IKBKG(2), INPP5D(8), JUN(2), LILRB3(6), LYN(13), MALT1(12), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NRAS(34), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RASGRP3(8), SYK(5), VAV1(22), VAV2(18)	34783365	833	265	613	294	172	255	147	159	100	0	0.129	1.000	1.000
176	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	116	ALCAM(11), CADM1(15), CADM3(13), CD2(7), CD22(15), CD226(4), CD274(4), CD276(6), CD28(4), CD34(7), CD4(4), CD40(6), CD40LG(10), CD6(5), CD80(4), CD86(2), CD8A(1), CD8B(4), CDH15(2), CDH2(33), CDH3(7), CDH4(19), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CNTN1(26), CNTN2(12), CNTNAP1(14), CNTNAP2(33), CTLA4(4), ESAM(6), F11R(4), GLG1(13), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA2(4), HLA-DQB1(1), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), ICAM1(4), ICAM2(5), ICAM3(3), ICOS(2), ICOSLG(4), ITGA4(14), ITGA6(14), ITGA8(16), ITGA9(9), ITGAL(18), ITGAM(13), ITGAV(17), ITGB1(12), ITGB2(16), ITGB7(7), ITGB8(9), JAM2(2), JAM3(9), L1CAM(14), MAG(9), MPZ(2), MPZL1(7), NCAM1(16), NCAM2(21), NEGR1(4), NEO1(12), NFASC(37), NLGN1(18), NLGN2(4), NLGN3(10), NRCAM(17), NRXN1(41), NRXN2(21), NRXN3(33), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(27), PTPRF(21), PTPRM(38), PVR(1), PVRL1(7), PVRL2(4), PVRL3(4), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SELE(11), SELL(5), SELP(13), SIGLEC1(17), SPN(4), VCAM1(12), VCAN(60)	69436192	1093	264	1035	437	334	166	135	278	175	5	0.862	1.000	1.000
177	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(11), ASAH1(4), ATF1(5), BRAF(111), CAMP(1), CREB1(3), CREB3(5), CREB5(5), CREBBP(68), CRKL(5), DAG1(8), EGR1(11), EGR2(14), EGR3(6), EGR4(3), ELK1(4), FRS2(4), GNAQ(10), JUN(2), MAP1B(38), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), NTRK1(16), OPN1LW(3), PIK3C2G(19), PIK3CA(288), PIK3CD(10), PIK3R1(53), PTPN11(31), RPS6KA3(13), SHC1(13), SRC(3), TERF2IP(3)	24336430	859	264	596	339	121	288	146	193	107	4	0.768	1.000	1.000
178	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	149	ADORA1(14), ADORA2A(4), ADORA2B(5), ADORA3(14), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCBP2(9), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CCRL1(4), CCRL2(5), CHML(21), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CMKLR1(5), CNR1(10), CNR2(1), CX3CR1(5), CXCR3(4), CXCR4(6), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2R(11), F2RL1(7), F2RL2(6), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GPR17(2), GPR173(3), GPR174(8), GPR3(3), GPR35(3), GPR37(12), GPR37L1(8), GPR4(6), GPR44(2), GPR50(9), GPR6(7), GPR63(4), GPR77(3), GPR83(6), GPR85(6), GPR87(11), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HTR1A(15), HTR1B(11), HTR1D(4), HTR1E(15), HTR1F(9), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LHCGR(27), LTB4R(1), MAS1(2), MC1R(2), MC3R(13), MC4R(6), MC5R(7), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPN1SW(8), OPN3(6), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OR10A5(3), OR12D3(1), OR1C1(9), OR1F1(4), OR1Q1(4), OR2H1(3), OR7A5(4), OR8B8(5), OXTR(2), P2RY1(5), P2RY10(12), P2RY12(5), P2RY14(9), P2RY2(6), P2RY6(5), PPYR1(5), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), RGR(3), RHO(4), RRH(5), SSTR1(11), SSTR2(4), SSTR4(12), SUCNR1(3), TRHR(7)	56124937	1040	263	942	403	380	212	136	207	104	1	0.0935	1.000	1.000
179	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(14), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), MINPP1(4), MIOX(3), OCRL(16), PI4KA(24), PI4KB(5), PIK3C3(25), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14)	36740407	1053	261	768	388	197	383	160	193	111	9	0.477	1.000	1.000
180	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(11), AKT2(7), AKT3(7), BRD4(21), CAP1(4), CBL(38), CDC42(2), CDKN2A(7), F2RL2(6), FLOT1(6), FLOT2(2), GRB2(9), GSK3A(6), GSK3B(16), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), LNPEP(21), MAPK1(3), MAPK3(3), PARD3(11), PARD6A(1), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3R1(53), PPYR1(5), PTEN(286), PTPN1(10), RAF1(13), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SERPINB6(2), SFN(1), SHC1(13), SLC2A4(7), SORBS1(11), SOS1(11), SOS2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	29071866	1043	261	726	357	158	411	161	186	118	9	0.0342	1.000	1.000
181	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(11), AKT2(7), AKT3(7), BAD(1), CASP9(5), CDC42(2), HRAS(4), KDR(38), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPKAPK2(4), MAPKAPK3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NOS3(21), NRAS(34), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCA(5), PRKCG(19), PTGS2(9), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAF1(13), SH2D2A(4), SHC2(2), SPHK1(2), SPHK2(5), SRC(3), VEGFA(5)	34334899	808	260	592	308	181	233	143	151	100	0	0.537	1.000	1.000
182	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	AKT1(11), AKT2(7), AKT3(7), CCL4(1), CD14(6), CD40(6), CD80(4), CD86(2), CXCL10(1), CXCL11(3), CXCL9(6), FADD(1), FOS(4), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IKBKB(7), IKBKE(8), IKBKG(2), IL12A(1), IL12B(1), IL1B(4), IL6(5), IL8(5), IRAK1(6), IRAK4(6), IRF3(2), IRF5(6), JUN(2), LBP(7), LY96(4), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K7(7), MAP3K8(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), RAC1(2), RELA(9), RIPK1(7), SPP1(4), STAT1(15), TBK1(11), TICAM1(15), TIRAP(5), TLR1(8), TLR2(7), TLR3(13), TLR4(15), TLR5(7), TLR6(12), TLR7(15), TLR8(11), TLR9(12), TNF(1), TOLLIP(5), TRAF3(10), TRAF6(4)	43007984	915	260	725	320	172	263	149	204	125	2	0.251	1.000	1.000
183	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(11), AKT2(7), AKT3(7), BCR(11), BTK(11), CD19(10), CDKN2A(7), DAPP1(3), FLOT1(6), FLOT2(2), GAB1(15), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), PDK1(5), PHF11(3), PIK3CA(288), PITX2(2), PLCG2(23), PPP1R13B(9), PREX1(22), PTEN(286), PTPRC(27), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SAG(5), SYK(5), TEC(8), VAV1(22)	27714304	982	260	715	361	161	378	166	173	96	8	0.397	1.000	1.000
184	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ATF4(2), CACNA1C(32), CACNA1D(28), CACNA1F(35), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDC42(2), CGA(2), EGFR(104), ELK1(4), FSHB(4), GNA11(8), GNAQ(10), GNAS(35), GNRH1(4), GNRH2(5), GNRHR(9), GRB2(9), HBEGF(1), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), LHB(3), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK9(10), MMP14(6), MMP2(12), NRAS(34), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLD1(16), PLD2(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(15), PRKX(3), PTK2B(13), RAF1(13), SOS1(11), SOS2(15), SRC(3)	64061821	1120	258	1016	381	343	222	154	255	143	3	0.0797	1.000	1.000
185	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(22), ADCY8(30), ARAF(10), ATF4(2), BRAF(111), CACNA1C(32), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CREBBP(68), EP300(42), GNAQ(10), GRIA1(35), GRIA2(23), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), NRAS(34), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PPP1R1A(1), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), RAF1(13), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15)	50474396	993	257	857	394	294	227	117	236	118	1	0.861	1.000	1.000
186	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(12), CRKL(5), DOCK1(22), ELK1(4), FOS(4), GAB1(15), GRB2(9), HGF(13), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K1(10), MAP2K2(2), MAP4K1(6), MAPK1(3), MAPK3(3), MAPK8(11), MET(48), PAK1(10), PIK3CA(288), PIK3R1(53), PTEN(286), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAF1(13), RAP1A(1), RAP1B(2), RASA1(20), SOS1(11), SRC(3), STAT3(10)	23116493	964	257	652	370	106	431	149	175	95	8	0.430	1.000	1.000
187	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(10), BRAF(111), C7orf16(11), CACNA1A(27), CRHR1(4), GNA11(8), GNA12(6), GNA13(3), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAS(35), GNAZ(3), GRIA1(35), GRIA2(23), GRIA3(11), GRID2(25), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), IGF1(6), IGF1R(17), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), NOS1(23), NOS3(21), NPR1(16), NPR2(15), NRAS(34), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), RAF1(13), RYR1(58)	55511904	1061	256	908	397	337	190	136	260	136	2	0.675	1.000	1.000
188	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(13), CREBBP(68), DUSP1(6), EHHADH(13), EP300(42), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(3), ME1(11), MRPL11(1), MYC(5), NCOA1(13), NCOR1(30), NCOR2(38), NFKBIA(1), NR1H3(16), NR2F1(5), NRIP1(17), PDGFA(2), PIK3CA(288), PIK3R1(53), PPARA(7), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PTGS2(9), RB1(123), RELA(9), RXRA(8), SP1(6), SRA1(2), STAT5A(8), STAT5B(19), TNF(1)	31649689	896	253	638	320	144	304	130	164	146	8	0.321	1.000	1.000
189	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(11), AKT2(7), AKT3(7), BRAF(111), CAB39(2), EIF4B(4), FIGF(4), HIF1A(14), IGF1(6), MAPK1(3), MAPK3(3), PDPK1(4), PGF(3), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PRKAA1(8), PRKAA2(15), RHEB(4), RICTOR(24), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), STK11(36), TSC1(17), TSC2(15), ULK2(14), ULK3(3), VEGFA(5), VEGFB(3), VEGFC(11)	25276914	811	252	558	290	135	273	128	179	94	2	0.266	1.000	1.000
190	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	80	ACVR1(6), ACVR1C(9), ACVR2B(12), ACVRL1(7), AMHR2(4), BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BMPR1B(14), CHRD(14), COMP(6), CREBBP(68), CUL1(16), DCN(7), E2F4(2), E2F5(6), EP300(42), FST(4), GDF5(11), GDF6(6), ID1(2), ID4(1), IFNG(3), INHBA(17), INHBB(3), INHBC(3), INHBE(2), LEFTY1(2), LEFTY2(1), LTBP1(20), MAPK1(3), MAPK3(3), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), RBL1(18), RBL2(22), ROCK1(27), ROCK2(15), RPS6KB1(9), RPS6KB2(4), SKP1(2), SMAD1(10), SMAD3(17), SMAD4(166), SMAD5(3), SMAD7(1), SMAD9(5), SMURF1(7), SMURF2(6), SP1(6), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNF(1), ZFYVE16(20), ZFYVE9(18)	46534524	864	249	757	335	255	184	105	182	130	8	0.827	1.000	1.000
191	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), BCR(11), BLNK(1), BTK(11), CD19(10), CD22(15), CR2(20), CSK(3), DAG1(8), FLOT1(6), FLOT2(2), GRB2(9), GSK3A(6), GSK3B(16), INPP5D(8), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP4K1(6), MAPK1(3), MAPK3(3), NFATC2(10), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3R1(53), PLCG2(23), PPP1R13B(9), PPP3CA(3), PPP3CB(10), PPP3CC(5), PTPRC(27), RAF1(13), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22)	35931441	822	249	629	268	180	257	142	145	97	1	0.0157	1.000	1.000
192	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(11), EIF4A2(10), EIF4G1(17), EIF4G2(16), EIF4G3(16), GHR(12), IRS1(17), MAPK1(3), MAPK14(7), MAPK3(3), MKNK1(2), PABPC1(8), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PRKCA(5), PTEN(286), RPS6KB1(9)	14448221	775	246	492	292	74	353	129	133	78	8	0.318	1.000	1.000
193	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(11), AKT2(7), AKT3(7), BAD(1), BTK(11), CDKN2A(7), DAPP1(3), GRB2(9), GSK3A(6), GSK3B(16), IARS(9), IGFBP1(2), INPP5D(8), PDK1(5), PIK3CA(288), PPP1R13B(9), PTEN(286), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SOS1(11), SOS2(15), TEC(8), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	18320288	806	244	537	297	96	352	127	140	82	9	0.207	1.000	1.000
194	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADK(7), ADSL(13), ADSS(5), ADSSL1(6), AK1(1), AK5(7), AK7(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), FHIT(1), GART(5), GDA(6), GMPR(8), GMPR2(3), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NPR1(16), NPR2(15), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE10A(12), PDE11A(13), PDE1A(8), PDE1C(17), PDE2A(10), PDE3B(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6D(2), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PPAT(5), PRIM1(5), PRIM2(2), PRPS1(8), PRPS1L1(3), PRPS2(6), PRUNE(3), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), XDH(19)	84224133	1080	243	1025	378	310	182	169	244	174	1	0.277	1.000	1.000
195	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(11), EIF4A2(10), EIF4B(4), EIF4G1(17), EIF4G2(16), EIF4G3(16), FKBP1A(1), MKNK1(2), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9), TSC1(17), TSC2(15)	13829440	762	242	481	290	76	357	118	121	82	8	0.299	1.000	1.000
196	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM2(1), CALM3(1), CD3D(4), CD3E(2), ELK1(4), FOS(4), FYN(15), GRB2(9), HRAS(4), JUN(2), LAT(2), LCK(8), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PIK3CA(288), PIK3R1(53), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), PTPN7(3), RAC1(2), RAF1(13), RASA1(20), RELA(9), SHC1(13), SOS1(11), SYT1(14), VAV1(22), ZAP70(12)	23660953	673	241	470	233	130	237	111	103	90	2	0.0770	1.000	1.000
197	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(11), CALM2(1), CALM3(1), ELK1(4), FCER1A(5), FOS(4), GRB2(9), HRAS(4), JUN(2), LYN(13), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PAK2(14), PIK3CA(288), PIK3R1(53), PLA2G4A(13), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), RAF1(13), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22)	21191001	646	240	450	210	111	234	115	109	75	2	0.0153	1.000	1.000
198	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(11), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), GSK3B(16), IGF1(6), IGF1R(17), INPPL1(14), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9)	10227367	738	239	460	286	70	358	116	114	72	8	0.482	1.000	1.000
199	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(7), EGF(7), EGFR(104), ELK1(4), FOS(4), GRB2(9), HRAS(4), JAK1(20), JUN(2), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8)	19546751	692	238	486	246	113	256	121	124	76	2	0.198	1.000	1.000
200	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCR(11), BLNK(1), BTK(11), CD19(10), CSK(3), DAG1(8), EPHB2(15), GRB2(9), ITPKA(3), ITPKB(14), LYN(13), MAP2K1(10), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PI3(2), PIK3CA(288), PIK3CD(10), PIK3R1(53), PLCG2(23), PPP1R13B(9), RAF1(13), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22)	25601947	636	238	447	207	133	218	115	107	62	1	0.0134	1.000	1.000
201	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(11), BCAR1(5), CDKN1B(4), GRB2(9), ILK(3), ITGB1(12), MAPK1(3), MAPK3(3), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PTEN(286), PTK2(24), SHC1(13), SOS1(11)	9660530	737	237	452	277	56	357	117	121	77	9	0.291	1.000	1.000
202	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(2), CDK5R1(5), CFL1(2), CHN1(5), LIMK1(7), MAP3K1(18), MYL2(2), MYLK(29), NCF2(8), PAK1(10), PDGFRA(56), PIK3CA(288), PIK3R1(53), PLD1(16), PPP1R12B(28), RAC1(2), RALBP1(6), RPS6KB1(9), TRIO(38), VAV1(22), WASF1(3)	18187178	611	236	416	216	91	226	107	105	78	4	0.228	1.000	1.000
203	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(11), AKT2(7), AKT3(7), BPNT1(9), GRB2(9), ILK(3), MAPK1(3), MAPK3(3), PDK1(5), PIK3CA(288), PIK3CD(10), PTEN(286), PTK2B(13), RBL2(22), SHC1(13), SOS1(11)	10305903	700	236	432	264	60	328	117	123	63	9	0.488	1.000	1.000
204	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	89	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), AKAP1(7), AKAP10(5), AKAP11(26), AKAP12(30), AKAP2(2), AKAP3(22), AKAP4(14), AKAP5(5), AKAP6(37), AKAP7(20), AKAP8(7), AKAP9(66), ARHGEF1(13), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(6), GNA13(3), GNA14(10), GNA15(5), GNAI2(2), GNAI3(2), GNAL(4), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(1), GNG4(1), GNG7(2), HRAS(4), IL18BP(1), ITPR1(41), KCNJ3(11), NRAS(34), PALM2(1), PDE1A(8), PDE1B(10), PDE1C(17), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PLCB3(14), PPP3CA(3), PPP3CC(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKD3(15), RRAS(2), SLC9A1(9), USP5(9)	59049658	914	235	822	334	262	163	113	207	167	2	0.503	1.000	1.000
205	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(12), AGT(10), AKT1(11), CALM2(1), CALM3(1), CALR(1), CAMK1(7), CAMK1G(5), CAMK4(6), CREBBP(68), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(9), FGF2(5), FKBP1A(1), GATA4(4), GSK3B(16), HAND1(4), HAND2(1), HRAS(4), IGF1(6), LIF(1), MAP2K1(10), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MEF2C(15), MYH2(37), NFATC2(10), NFATC3(13), NFATC4(11), NPPA(1), PIK3CA(288), PIK3R1(53), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RAF1(13), RPS6KB1(9), SYT1(14)	24877898	722	235	531	265	146	245	117	129	84	1	0.255	1.000	1.000
206	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(8), EIF1(2), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), ELAVL1(5), FLT1(34), FLT4(16), HIF1A(14), HRAS(4), KDR(38), NOS3(21), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), PTK2(24), PXN(2), SHC1(13), VHL(83)	16757573	667	232	443	261	84	272	117	111	82	1	0.669	1.000	1.000
207	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), JAK1(20), JUN(2), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), PDGFA(2), PDGFRA(56), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8)	18171110	639	231	439	220	101	232	112	114	76	4	0.138	1.000	1.000
208	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(6), GORASP1(11), IKBKG(2), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PIK3CA(288), PIK3CD(10), PIK3R1(53), SYT1(14), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4)	14642055	549	229	364	188	86	212	99	97	54	1	0.103	1.000	1.000
209	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), GRB2(9), GSK3A(6), GSK3B(16), IL4R(6), IRS1(17), JAK1(20), JAK3(27), MAP4K1(6), MAPK1(3), MAPK3(3), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3R1(53), PPP1R13B(9), RAF1(13), SHC1(13), SOS1(11), SOS2(15), STAT6(4)	17627868	562	229	366	185	92	217	98	88	66	1	0.0578	1.000	1.000
210	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), DAG1(8), DGKA(8), ETFA(4), GCA(1), ITGA9(9), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K1(10), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(10), PDE3A(19), PDE3B(8), PI3(2), PIK3C2G(19), PIK3CA(288), PIK3CD(10), PIK3R1(53), PLDN(1), PSME1(1), RIPK3(5), RPS4X(1), SGCB(3), VASP(4)	24181027	640	229	469	235	117	215	112	121	74	1	0.359	1.000	1.000
211	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(51), ASH2L(6), C17orf79(1), CARM1(3), CTCFL(18), DOT1L(9), EED(2), EHMT1(9), EHMT2(7), EZH1(8), EZH2(49), FBXO11(14), HCFC1(11), HSF4(4), JMJD4(1), JMJD6(8), KDM6A(26), MEN1(26), MLL(50), MLL2(59), MLL3(75), MLL4(36), MLL5(26), NSD1(25), OGT(8), PAXIP1(17), PPP1CA(2), PPP1CB(5), PPP1CC(1), PRDM2(34), PRDM7(5), PRDM9(33), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), RBBP5(4), SATB1(16), SETD1A(20), SETD2(47), SETD7(7), SETD8(6), SETDB1(18), SETDB2(4), SETMAR(3), SMYD3(4), STK38(7), SUV39H1(4), SUV39H2(6), SUV420H1(13), SUV420H2(1), SUZ12(4), WHSC1(25), WHSC1L1(10)	59429634	856	228	755	275	222	194	76	187	166	11	0.356	1.000	1.000
212	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(22), AKT1(11), BAD(1), BAX(14), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(17), IL3(6), KIT(139), KITLG(3), PIK3CA(288), PIK3R1(53), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), YWHAH(3)	10827843	604	227	392	228	85	275	99	87	57	1	0.475	1.000	1.000
213	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MIOX(3), OCRL(16), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CA(288), PIK3CB(5), PIK3CG(36), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23)	22475976	589	227	415	216	120	191	112	111	54	1	0.420	1.000	1.000
214	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(22), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), GNAS(35), GRB2(9), HRAS(4), MAPK1(3), MAPK14(7), MAPK3(3), PIK3CA(288), PIK3R1(53), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RAC1(2), RPS6KA1(9), RPS6KA5(10), SOS1(11)	14713827	526	226	341	187	96	211	93	80	46	0	0.153	1.000	1.000
215	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(11), BCL2(2), BCR(11), CRKL(5), FOS(4), GRB2(9), HRAS(4), JAK2(48), JUN(2), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), MYC(5), PIK3CA(288), PIK3R1(53), RAF1(13), SOS1(11), STAT1(15), STAT5A(8), STAT5B(19)	13998178	582	226	386	198	87	231	107	95	59	3	0.0530	1.000	1.000
216	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(68), EP300(42), FYN(15), IL2RG(8), IL7(3), IL7R(12), JAK1(20), JAK3(27), LCK(8), NMI(3), PIK3CA(288), PIK3R1(53), PTK2B(13), STAT5A(8), STAT5B(19)	14495252	589	226	391	216	86	232	99	95	77	0	0.423	1.000	1.000
217	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	DIAPH1(7), FYN(15), GSN(4), HRAS(4), ITGA1(12), ITGB1(12), MAP2K1(10), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PIK3CA(288), PIK3R1(53), PTK2(24), PXN(2), RAF1(13), ROCK1(27), SHC1(13), SRC(3), TLN1(21)	18192621	545	225	352	195	81	195	106	88	69	6	0.218	1.000	1.000
218	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	27	AKT1(11), CABIN1(22), CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), HDAC5(13), IGF1(6), IGF1R(17), INSR(20), MAP2K6(4), MAPK14(7), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NFATC2(10), PIK3CA(288), PIK3R1(53), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYT1(14), YWHAH(3)	16301590	529	225	355	205	90	206	95	88	50	0	0.499	1.000	1.000
219	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	87	AKT1(11), AKT3(7), BCAR1(5), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(8), CAPN3(10), CAPN5(11), CAPN6(13), CAPN7(11), CAPN9(5), CAPNS1(4), CAV2(4), CAV3(3), CDC42(2), CSK(3), DOCK1(22), FYN(15), GIT2(10), GRB2(9), ILK(3), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAV(17), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAPK10(14), MAPK12(4), MAPK4(4), MAPK7(6), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAP1B(2), RAPGEF1(19), RHO(4), ROCK1(27), ROCK2(15), SDCCAG8(2), SEPP1(3), SHC1(13), SHC3(5), SORBS1(11), SOS1(11), SRC(3), TLN1(21), TNS1(34), VASP(4), VAV2(18), VCL(9), ZYX(2)	65778038	862	225	803	333	255	134	96	209	159	9	0.919	1.000	1.000
220	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(11), AKT2(7), AKT3(7), CISH(2), GRB2(9), IARS(9), IL13RA1(5), IL2RG(8), IL4(5), IL4R(6), INPP5D(8), JAK1(20), JAK2(48), JAK3(27), PI3(2), PIK3CA(288), PPP1R13B(9), RPS6KB1(9), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT6(4), TYK2(5)	18606319	536	225	357	196	79	208	97	93	56	3	0.365	1.000	1.000
221	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(22), AKT1(11), ASAH1(4), GNAI1(3), GNB1(3), ITGAV(17), ITGB3(12), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(56), PIK3CA(288), PIK3R1(53), PLCB1(22), PRKCA(5), PTK2(24), RAC1(2), SMPD1(9), SMPD2(3), SPHK1(2), SRC(3)	14163896	547	224	360	209	78	220	103	95	47	4	0.390	1.000	1.000
222	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(11), CREB1(3), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NFKB1(8), PIK3CA(288), PIK3R1(53), RB1(123), RELA(9), SP1(6)	10207139	556	224	347	190	70	233	96	95	54	8	0.0361	1.000	1.000
223	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(39), ABCA10(31), ABCA12(66), ABCA13(70), ABCA3(22), ABCA4(31), ABCA5(33), ABCA6(28), ABCA7(21), ABCA8(23), ABCA9(32), ABCB1(29), ABCB10(10), ABCB11(19), ABCB4(23), ABCB5(24), ABCB6(7), ABCB7(6), ABCB8(8), ABCB9(5), ABCC1(20), ABCC10(18), ABCC11(14), ABCC12(22), ABCC2(18), ABCC3(10), ABCC4(24), ABCC5(20), ABCC6(9), ABCC8(21), ABCC9(22), ABCD1(5), ABCD2(18), ABCD3(5), ABCD4(10), ABCG1(7), ABCG2(12), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(16), TAP1(7), TAP2(15)	57548332	848	223	825	259	221	133	99	240	145	10	0.0122	1.000	1.000
224	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADK(7), ADSL(13), ADSS(5), AK1(1), AK5(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), ATP1B1(4), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), FHIT(1), GART(5), GDA(6), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NPR1(16), NPR2(15), NT5C(1), NT5E(6), NT5M(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE1A(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6B(11), PDE6C(10), PDE7B(4), PDE8A(6), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), PPAT(5), PRPS1(8), PRPS1L1(3), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5)	64966444	853	223	804	289	250	139	121	205	137	1	0.297	1.000	1.000
225	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(4), GHR(12), GRB2(9), HRAS(4), INSR(20), IRS1(17), JAK2(48), MAP2K1(10), MAPK1(3), MAPK3(3), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), PTPN6(4), RAF1(13), RPS6KA1(9), SHC1(13), SLC2A4(7), SOS1(11), SRF(4), STAT5A(8), STAT5B(19)	16773077	581	222	378	223	89	230	106	93	60	3	0.659	1.000	1.000
226	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CBL(38), CFLAR(2), CRKL(5), FOS(4), GRB2(9), HRAS(4), IL2RA(3), IL2RB(4), IL2RG(8), IRS1(17), JAK1(20), JAK3(27), MAPK1(3), MAPK3(3), MYC(5), NMI(3), PIK3CA(288), PIK3R1(53), PPIA(1), PTPN6(4), RAF1(13), RPS6KB1(9), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19), SYK(5)	17775414	594	222	387	201	88	217	113	94	81	1	0.151	1.000	1.000
227	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	ATF2(6), BRAF(111), CREB1(3), DAXX(14), ELK1(4), FOS(4), GRB2(9), HRAS(4), IKBKB(7), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP3K9(9), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAP4K5(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK4(4), MAPK7(6), MAPK8(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MKNK2(6), MYC(5), NFKB1(8), NFKBIA(1), PAK1(10), PAK2(14), RAC1(2), RAF1(13), RELA(9), RIPK1(7), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KB1(9), RPS6KB2(4), SHC1(13), SP1(6), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8)	45746539	787	221	663	237	197	165	108	186	128	3	0.0360	1.000	1.000
228	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	76	ANPEP(16), CD14(6), CD19(10), CD1A(4), CD1B(5), CD1C(3), CD1D(5), CD2(7), CD22(15), CD33(2), CD34(7), CD36(3), CD37(4), CD38(4), CD3D(4), CD3E(2), CD4(4), CD44(5), CD5(7), CD55(7), CD7(4), CD8A(1), CD8B(4), CD9(3), CR1(19), CR2(20), CSF1(4), CSF1R(15), CSF3(2), CSF3R(18), DNTT(11), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(27), FLT3LG(1), GP5(8), GP9(1), HLA-DRB1(6), HLA-DRB5(2), IL11(6), IL11RA(4), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL2RA(3), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL7(3), IL7R(12), ITGA1(12), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGAM(13), ITGB3(12), KIT(139), KITLG(3), MME(23), MS4A1(7), TFRC(5), THPO(5), TNF(1), TPO(29)	40253918	683	220	617	256	173	175	95	155	81	4	0.359	1.000	1.000
229	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), HRAS(4), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(10), PIK3CA(288), PIK3R1(53), RAC1(2), RAF1(13), RB1(123), RELA(9), TFDP1(10)	10421504	563	220	346	203	70	237	98	93	57	8	0.160	1.000	1.000
230	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), INSR(20), IRS1(17), JUN(2), MAP2K1(10), MAPK3(3), MAPK8(11), PIK3CA(288), PIK3R1(53), PTPN11(31), RAF1(13), RASA1(20), SHC1(13), SLC2A4(7), SOS1(11), SRF(4)	12839363	531	217	336	188	78	212	101	85	54	1	0.114	1.000	1.000
231	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(22), ARHGEF1(13), F2(9), F2R(11), GNA12(6), GNA13(3), GNAI1(3), GNAQ(10), GNB1(3), MAP3K7(7), PIK3CA(288), PIK3R1(53), PLCB1(22), PPP1R12B(28), PRKCA(5), PTK2B(13), ROCK1(27)	13177737	523	217	324	193	78	201	84	84	72	4	0.603	1.000	1.000
232	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(7), FOS(4), GRB2(9), HRAS(4), JAK2(48), JUN(2), MAP2K1(10), MAPK3(3), MPL(5), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), RAF1(13), RASA1(20), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), STAT5B(19), THPO(5)	15708798	569	217	367	200	80	228	96	90	72	3	0.311	1.000	1.000
233	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(111), CPEB1(7), EGFR(104), ERBB2(28), ERBB4(56), ETS1(6), ETS2(4), ETV6(10), ETV7(3), GRB2(9), MAP2K1(10), MAPK1(3), MAPK3(3), NOTCH2(29), NOTCH3(27), NOTCH4(15), PIWIL1(27), PIWIL2(12), PIWIL3(12), PIWIL4(8), RAF1(13), SOS1(11), SOS2(15), SPIRE1(4), SPIRE2(7)	22585317	534	216	426	177	118	145	74	144	53	0	0.162	1.000	1.000
234	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(8), ADAM17(11), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CDC42(2), CSK(3), CXCL1(1), EGFR(104), F11R(4), GIT1(3), HBEGF(1), IGSF5(14), IKBKB(7), IKBKG(2), IL8(5), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP2K4(32), MAP3K14(6), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK8(11), MAPK9(10), MET(48), NFKB1(8), NFKB2(4), NFKBIA(1), NOD1(9), PAK1(10), PLCG1(17), PLCG2(23), PTPN11(31), PTPRZ1(37), RAC1(2), RELA(9), SRC(3), TCIRG1(6), TJP1(21)	35421393	618	216	540	216	138	190	84	129	76	1	0.243	1.000	1.000
235	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), IGF1(6), IGF1R(17), IRS1(17), JUN(2), MAP2K1(10), MAPK3(3), MAPK8(11), PIK3CA(288), PIK3R1(53), PTPN11(31), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SRF(4)	12482449	527	216	333	183	79	209	97	83	58	1	0.0937	1.000	1.000
236	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(5), CXCL12(2), CXCR4(6), GNAI1(3), GNAQ(10), GNB1(3), HRAS(4), MAP2K1(10), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(19), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), PTK2(24), PTK2B(13), PXN(2), RAF1(13), RELA(9)	13799166	500	214	325	196	73	200	95	81	50	1	0.597	1.000	1.000
237	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BTRC(7), CSNK1A1(3), CSNK1A1L(8), CSNK1D(14), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(6), DHH(4), FBXW11(12), GLI1(19), GLI2(22), GLI3(37), GSK3B(16), HHIP(15), IHH(5), LRP2(114), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(130), PTCH2(19), RAB23(3), SHH(3), SMO(11), STK36(16), SUFU(5), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3)	28682929	631	213	546	227	204	140	67	122	95	3	0.437	1.000	1.000
238	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(11), BAD(1), GRB2(9), HRAS(4), IGF1R(17), IRS1(17), MAP2K1(10), MAPK1(3), MAPK3(3), PIK3CA(288), PIK3R1(53), RAF1(13), SHC1(13), SOS1(11), YWHAH(3)	9480494	456	211	272	152	65	186	92	65	47	1	0.0541	1.000	1.000
239	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	IL18(3), ITGB1(12), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LAT(2), MAP2K1(10), MAPK3(3), PAK1(10), PIK3CA(288), PIK3R1(53), PTK2B(13), PTPN6(4), RAC1(2), SYK(5), VAV1(22)	9359505	444	211	278	164	58	190	84	74	38	0	0.338	1.000	1.000
240	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(11), DPM2(1), GRB2(9), HRAS(4), KLK2(4), NTRK1(16), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), SHC1(13), SOS1(11)	8017310	432	211	254	165	42	186	90	67	46	1	0.526	1.000	1.000
241	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(11), CREB1(3), GRB2(9), HRAS(4), MAPK1(3), MAPK3(3), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NTRK1(16), PIK3CA(288), PIK3R1(53), PLCG1(17), RPS6KA1(9), SHC1(13)	9673636	458	210	284	172	59	193	91	67	47	1	0.512	1.000	1.000
242	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(11), ANXA1(3), CALM2(1), CALM3(1), GNAS(35), GNB1(3), NFKB1(8), NOS3(21), NPPA(1), NR3C1(8), PIK3CA(288), PIK3R1(53), RELA(9), SYT1(14)	8574871	459	210	269	162	71	195	84	65	44	0	0.180	1.000	1.000
243	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(11), PIK3CA(288), PIK3R1(53), PLCB1(22), PLCG1(17), PRKCA(5), VAV1(22)	6803008	418	210	250	160	52	185	85	63	33	0	0.533	1.000	1.000
244	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(11), AKT2(7), AKT3(7), CDKN1A(2), ELK1(4), GRB2(9), HRAS(4), MAP2K1(10), MAP2K2(2), NGFR(4), NTRK1(16), PIK3CA(288), PIK3CD(10), SHC1(13), SOS1(11)	7874228	398	210	241	157	54	156	91	66	30	1	0.582	1.000	1.000
245	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(38), CD28(4), CD3D(4), CSK(3), CTLA4(4), DAG1(8), EPHB2(15), FBXW7(119), GRAP2(3), GRB2(9), ITK(21), ITPKA(3), ITPKB(14), LAT(2), LCK(8), LCP2(9), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLCG1(17), PTPRC(27), RAF1(13), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), SOS1(11), SOS2(15), VAV1(22), ZAP70(12)	27476535	510	209	426	175	132	125	57	106	90	0	0.288	1.000	1.000
246	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHX58(4), ENPP1(17), ENPP3(10), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), G6PC(4), G6PC2(2), GAA(14), GANC(8), GBA(4), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), IFIH1(20), LYZL1(4), MGAM(26), MOV10L1(16), NUDT5(1), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SI(24), SKIV2L2(11), SMARCA2(19), SMARCA5(13), TREH(6), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UXS1(8)	64682837	798	208	738	240	226	141	97	180	151	3	0.0787	1.000	1.000
247	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(7), DPM2(1), ELK1(4), FOS(4), GRB2(9), HRAS(4), JUN(2), KLK2(4), MAP2K1(10), MAPK3(3), MAPK8(11), NGFR(4), PIK3CA(288), PIK3R1(53), PLCG1(17), RAF1(13), SHC1(13), SOS1(11)	9657767	458	208	278	163	62	190	89	69	47	1	0.202	1.000	1.000
248	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(11), BAD(1), BCL2L1(1), CASP9(5), CDC42(2), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(10), MAPK3(3), NFKB1(8), PIK3CA(288), PIK3R1(53), RAC1(2), RAF1(13), RALA(7), RALBP1(6), RALGDS(7), RELA(9)	8685323	435	208	263	155	68	179	92	59	37	0	0.0953	1.000	1.000
249	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(11), AKT2(7), AKT3(7), ASAH1(4), BRAF(111), DAG1(8), DRD2(7), EGFR(104), EPHB2(15), GRB2(9), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PI3(2), PIK3CB(5), PITX2(2), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), RAF1(13), RGS20(9), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT3(10), TERF2IP(3)	29425467	604	208	495	205	143	150	76	163	71	1	0.294	1.000	1.000
250	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(11), BAD(1), CHRNB1(10), CHRNG(6), MUSK(13), PIK3CA(288), PIK3R1(53), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(8), YWHAH(3)	8095453	438	207	269	165	54	186	87	67	44	0	0.522	1.000	1.000
251	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(4), CD3D(4), CD3E(2), CD80(4), CD86(2), CTLA4(4), GRB2(9), HLA-DRB1(6), ICOS(2), IL2(4), ITK(21), LCK(8), PIK3CA(288), PIK3R1(53), PTPN11(31)	6239700	442	206	259	158	42	206	85	70	37	2	0.163	1.000	1.000
252	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), PAK1(10), PDGFRA(56), PIK3CA(288), PIK3R1(53), RAC1(2), WASL(16)	7127008	453	205	279	166	47	193	90	81	40	2	0.161	1.000	1.000
253	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(11), CAT(7), GH1(4), GHR(12), HRAS(4), IGF1(6), IGF1R(17), PIK3CA(288), PIK3R1(53), SHC1(13), SOD2(4)	6687879	419	205	247	154	53	173	85	66	41	1	0.307	1.000	1.000
254	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	85	ACTB(4), BAD(1), BCL2(2), CABIN1(22), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(6), CD3E(2), CD69(2), CDKN1A(2), CNR1(10), CREBBP(68), CSNK2A1(7), CSNK2B(2), CTLA4(4), EGR2(14), EGR3(6), EP300(42), FCER1A(5), FCGR3A(4), FOS(4), FOSL1(1), GATA4(4), GRLF1(18), GSK3A(6), GSK3B(16), HRAS(4), ICOS(2), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL13(2), IL1B(4), IL2(4), IL2RA(3), IL3(6), IL4(5), IL6(5), IL8(5), ITK(21), KPNA5(12), MAPK14(7), MAPK8(11), MAPK9(10), MEF2A(5), MEF2D(3), MYF5(5), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB2(4), NFKBIB(5), NFKBIE(4), NPPB(4), NUP214(18), OPRD1(6), P2RX7(12), PAK1(10), PIN1(2), PPIA(1), PPP3CB(10), PPP3CC(5), PPP3R1(3), PTPRC(27), RELA(9), RPL13A(1), SFN(1), SLA(8), SP1(6), SP3(10), TGFB1(2), TNF(1), TRAF2(8), TRPV6(14), VAV1(22), VAV2(18), XPO5(8)	42723640	652	203	607	245	196	157	76	134	89	0	0.545	1.000	1.000
255	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(5), ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG6(5), ALG8(12), ALG9(7), B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT5(4), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(9), CHST11(4), CHST12(4), CHST14(1), CHST2(11), CHST3(6), CHST4(6), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(12), EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), FUT11(2), FUT8(10), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GANAB(12), GCNT1(7), GCNT3(4), GCNT4(12), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), NDST1(9), NDST2(9), NDST3(15), NDST4(13), OGT(8), RPN1(4), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(5), STT3B(9), UST(10), XYLT1(12), XYLT2(15)	53852050	750	203	697	274	248	125	85	161	131	0	0.879	1.000	1.000
256	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(37), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ADIPOR1(2), ADIPOR2(5), AKT1(11), AKT2(7), AKT3(7), CAMKK1(2), CAMKK2(8), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), G6PC(4), G6PC2(2), IKBKB(7), IKBKG(2), IRS1(17), IRS4(30), JAK1(20), JAK2(48), JAK3(27), LEP(1), LEPR(15), MAPK10(14), MAPK8(11), MAPK9(10), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NPY(5), PCK1(3), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKCQ(15), PTPN11(31), RELA(9), RXRA(8), RXRB(7), RXRG(10), SLC2A1(5), SLC2A4(7), STAT3(10), STK11(36), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5)	40214324	651	203	573	211	179	168	89	130	83	2	0.0394	1.000	1.000
257	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(22), BDKRB1(3), BDKRB2(4), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(14), C2(6), C3(23), C3AR1(10), C4A(3), C4BPA(6), C4BPB(1), C5(20), C5AR1(7), C6(24), C7(10), C8A(11), C8B(22), C8G(1), C9(11), CD46(3), CD55(7), CFB(5), CFH(25), CFI(9), CPB2(10), CR1(19), CR2(20), F10(5), F11(8), F12(5), F13A1(12), F13B(10), F2(9), F2R(11), F3(1), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), KNG1(8), MASP1(19), MASP2(10), MBL2(3), PLAT(10), PLAU(6), PLAUR(7), PLG(23), PROC(3), PROS1(9), SERPINA1(6), SERPINA5(8), SERPINC1(8), SERPIND1(5), SERPINE1(8), SERPINF2(4), SERPING1(5), TFPI(6), THBD(3), VWF(30)	48091564	693	202	656	256	173	113	103	171	129	4	0.804	1.000	1.000
258	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(200), BMPR1B(14), CCND2(3), CDK4(3), CDKN1B(4), DAZL(2), DMC1(6), EGR1(11), ESR2(8), FSHR(16), GJA4(3), INHA(6), LHCGR(27), MLH1(62), MSH5(7), NCOR1(30), NR5A1(5), NRIP1(17), PGR(15), PRLR(8), PTGER2(2), SMPD1(9), VDR(3), ZP2(14)	17832591	475	202	385	163	88	144	47	98	92	6	0.420	1.000	1.000
259	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(11), BAD(1), CASP9(5), GH1(4), GHR(12), NFKB1(8), NFKBIA(1), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), RELA(9), YWHAH(3)	6576788	402	201	235	151	47	175	84	63	33	0	0.221	1.000	1.000
260	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	49	ADORA3(14), ALG6(5), CCKBR(12), CCR2(7), CCR3(9), CCR5(11), CELSR1(27), CELSR2(31), CELSR3(27), CHRM2(25), CHRM3(21), CIDEB(1), CXCR3(4), EDNRA(8), EMR2(7), EMR3(18), F2R(11), FSHR(16), GHRHR(2), GNRHR(9), GPR116(16), GPR132(6), GPR133(15), GPR143(4), GPR17(2), GPR18(3), GPR55(2), GPR56(5), GPR61(9), GPR77(3), GPR84(5), GPR88(4), GRM1(32), GRPR(4), HRH4(6), LGR6(8), LPHN2(26), LPHN3(26), NTSR1(5), OR2M4(15), OR8G1(3), OR8G2(9), PTGFR(7), SMO(11), SSTR2(4), TAAR5(8), VN1R1(7)	29749939	510	196	461	177	161	99	51	119	79	1	0.263	1.000	1.000
261	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	48	ACTG1(6), APAF1(23), ARHGDIB(5), BAG4(10), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CFLAR(2), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), GSN(4), LMNB1(9), LMNB2(2), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK8(11), MDM2(11), NFKB1(8), NFKBIA(1), NUMA1(21), PAK2(14), PRKCD(15), PRKDC(80), PSEN1(3), PSEN2(6), PTK2(24), RASA1(20), RB1(123), RELA(9), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8)	32660940	562	191	474	195	115	163	49	121	104	10	0.605	1.000	1.000
262	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), BTRC(7), CDC16(5), CDC20(3), CDC23(12), CDC26(1), CDC27(16), CUL1(16), CUL2(14), CUL3(8), FBXW11(12), FBXW7(119), FZR1(3), ITCH(7), SKP1(2), SKP2(3), SMURF1(7), SMURF2(6), TCEB2(1), UBA1(8), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D4(1), UBE2E1(4), UBE2E2(3), UBE2E3(1), VHL(83), WWP1(18), WWP2(8)	21191379	410	185	325	150	104	102	42	95	65	2	0.560	1.000	1.000
263	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	BCL2(2), DAXX(14), EGF(7), EGFR(104), ETS1(6), ETS2(4), FOS(4), HOXA7(3), HRAS(4), IKBKB(7), JUN(2), MAP2K1(10), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK1(3), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), NFKB1(8), NFKBIA(1), PPP2CA(3), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), RAF1(13), RELA(9), RIPK1(7), SP1(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	23860956	409	184	365	154	108	119	60	80	41	1	0.425	1.000	1.000
264	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(104), ELK1(4), GNAS(35), GNB1(3), GRB2(9), HRAS(4), IGF1R(17), ITGB1(12), KLK2(4), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MYC(5), NGFR(4), PDGFRA(56), PPP2CA(3), PTPRR(11), RAF1(13), RPS6KA1(9), RPS6KA5(10), SHC1(13), SOS1(11), SRC(3), STAT3(10)	16844829	367	183	309	134	101	111	50	65	37	3	0.323	1.000	1.000
265	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	60	AGTR1(12), ATP8A1(11), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CX3CR1(5), CXCR3(4), CXCR4(6), CXCR6(1), EDNRA(8), EDNRB(13), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(3), GRPR(4), LHCGR(27), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), NMBR(3), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), PPYR1(5), SSTR1(11), SSTR2(4), SSTR4(12), TAC4(4), TACR1(9), TACR2(4), TACR3(11), TRHR(7)	23979246	430	177	397	176	139	88	51	106	46	0	0.627	1.000	1.000
266	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(5), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CFLAR(2), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNB1(9), LMNB2(2), MAP2K4(32), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), PTPN13(20), RB1(123), RIPK2(5), SPTAN1(25)	20112687	412	175	344	150	63	122	41	104	71	11	0.789	1.000	1.000
267	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	40	ADAM17(11), APH1A(2), CREBBP(68), CTBP1(5), CTBP2(13), DLL1(6), DLL3(6), DLL4(5), DTX1(6), DTX2(8), DTX3(2), DTX3L(10), DTX4(8), DVL2(11), DVL3(8), EP300(42), HDAC1(5), HDAC2(8), HES1(2), JAG1(15), LFNG(5), MAML1(10), MAML2(8), MAML3(4), MFNG(1), NCOR2(38), NCSTN(6), NOTCH2(29), NOTCH3(27), NOTCH4(15), NUMB(10), NUMBL(6), PSEN1(3), PSEN2(6), PSENEN(2), PTCRA(4), RBPJ(16), RBPJL(11), RFNG(1), SNW1(9)	29172537	452	171	411	203	133	85	61	74	98	1	0.993	1.000	1.000
268	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(5), BAG4(10), CASP2(8), CASP3(3), CRADD(3), DFFA(4), DFFB(2), FADD(1), JUN(2), LMNB1(9), LMNB2(2), MADD(22), MAP2K4(32), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), RB1(123), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TRAF2(8)	18705294	411	171	341	139	77	118	35	95	74	12	0.470	1.000	1.000
269	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(6), CDC34(2), CDK2(5), CUL1(16), FBXW7(119), RB1(123), TFDP1(10)	4496395	281	169	188	98	59	85	14	63	52	8	0.304	1.000	1.000
270	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CLDN1(1), CTNNB1(99), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3)	24407661	429	169	367	176	97	102	55	98	73	4	0.904	1.000	1.000
271	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CLDN1(1), CTNNB1(99), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3)	24407661	429	169	367	176	97	102	55	98	73	4	0.904	1.000	1.000
272	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CAT(7), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADHA(10), KMO(13), KYNU(8), MAOA(5), MAOB(6), SDS(3), TDO2(8), TPH1(2), WARS(3), WARS2(6)	28384452	414	169	390	114	141	83	45	101	43	1	0.00328	1.000	1.000
273	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(7), CDC40(6), CLK2(3), CLK3(7), COL2A1(19), CPSF1(14), CPSF2(10), CPSF3(8), CPSF4(4), CSTF1(4), CSTF2(2), CSTF2T(11), CSTF3(11), DDIT3(4), DDX1(14), DDX20(6), DHX15(8), DHX16(18), DHX38(12), DHX8(14), DHX9(12), DICER1(23), DNAJC8(5), FUS(2), GIPC1(4), METTL3(5), NCBP1(8), NCBP2(2), NONO(12), NUDT21(1), NXF1(9), PABPN1(2), PAPOLA(7), PHF5A(1), POLR2A(12), PPM1G(3), PRPF18(4), PRPF3(9), PRPF4(9), PRPF4B(16), PRPF8(17), PSKH1(2), PTBP1(4), PTBP2(13), RBM17(6), RBM5(12), RNGTT(7), RNMT(5), RNPS1(1), SF3A1(10), SF3A2(4), SF3A3(1), SF3B1(17), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(2), SNRPA1(2), SNRPB(2), SNRPB2(3), SNRPD1(2), SNRPD3(1), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(8), SRPK2(9), SRRM1(15), SUPT5H(19), TXNL4A(2), U2AF1(3), U2AF2(6), XRN2(10)	53602003	545	168	517	180	147	82	60	133	122	1	0.879	1.000	1.000
274	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(10), AGTR1(12), ATF2(6), CALM2(1), CALM3(1), EGFR(104), ELK1(4), GNAQ(10), GRB2(9), HRAS(4), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), MEF2A(5), MEF2C(15), MEF2D(3), PAK1(10), PRKCA(5), PTK2(24), PTK2B(13), RAC1(2), RAF1(13), SHC1(13), SOS1(11), SRC(3), SYT1(14)	17556149	373	167	327	134	79	103	49	88	52	2	0.465	1.000	1.000
275	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(7), ACADL(4), ACADM(9), ACOX1(11), ACOX2(7), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP27A1(4), CYP4A11(7), CYP4A22(13), CYP7A1(13), CYP8B1(9), DBI(2), EHHADH(13), FABP1(2), FABP2(8), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FADS2(10), GK(5), GK2(13), HMGCS2(5), ILK(3), LPL(12), ME1(11), MMP1(5), NR1H3(16), OLR1(9), PCK1(3), PCK2(6), PDPK1(4), PLTP(10), PPARA(7), PPARD(4), PPARG(4), RXRA(8), RXRB(7), RXRG(10), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(6), SLC27A4(3), SLC27A5(7), SLC27A6(15), SORBS1(11), UBC(6), UCP1(8)	33574617	460	167	423	126	140	67	71	113	69	0	0.00355	1.000	1.000
276	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1C1(2), AKR1C2(2), AKR1C4(10), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), CYP1A1(9), CYP1A2(10), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2F1(6), CYP2S1(7), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7)	28869614	395	165	353	110	106	75	42	103	68	1	0.0310	1.000	1.000
277	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(12), AKT1(11), BDKRB2(4), CALM2(1), CALM3(1), CHRM1(4), CHRNA1(9), FLT1(34), FLT4(16), KDR(38), NOS3(21), PDE2A(10), PDE3A(19), PDE3B(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKG1(12), PRKG2(10), RYR2(122), SLC7A1(6), SYT1(14), TNNI1(2)	19429179	379	165	362	140	106	79	47	92	53	2	0.551	1.000	1.000
278	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	56	AADAT(1), AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), AFMID(2), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CARM1(3), CAT(7), CYP1A1(9), CYP1A2(10), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADH(2), HADHA(10), HEMK1(1), HSD17B10(2), HSD17B4(9), INMT(3), KMO(13), KYNU(8), LCMT1(1), LCMT2(6), LNX1(14), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), NFX1(8), OGDH(13), OGDHL(12), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), TDO2(8), TPH1(2), TPH2(9), WARS(3), WARS2(6), WBSCR22(2)	30693947	373	163	352	126	118	72	48	91	44	0	0.249	1.000	1.000
279	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(35), AR(20), ESR1(20), ESR2(8), HNF4A(8), NPM1(2), NR0B1(10), NR1D1(7), NR1D2(7), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(3), NR2C2(11), NR2E1(12), NR2F1(5), NR2F2(10), NR3C1(8), NR4A1(3), NR4A2(13), NR5A1(5), NR5A2(9), PGR(15), PPARA(7), PPARD(4), PPARG(4), RARA(5), RARB(18), RARG(10), ROR1(19), RORA(6), RORC(5), RXRA(8), RXRB(7), RXRG(10), THRA(6), THRB(14), VDR(3)	20201748	358	163	338	124	123	60	45	76	52	2	0.363	1.000	1.000
280	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(38), CSF1R(15), EGF(7), EGFR(104), GRB2(9), MET(48), PDGFRA(56), PRKCA(5), SH3GLB1(5), SH3GLB2(6), SH3KBP1(8), SRC(3)	10372119	304	161	263	129	42	126	45	68	21	2	0.736	1.000	1.000
281	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), CARM1(3), DBH(8), DCT(17), DDC(5), ECH1(2), ESCO1(16), ESCO2(13), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HEMK1(1), HGD(5), HPD(6), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), MYST3(28), MYST4(25), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SH3GLB1(5), TAT(14), TPO(29), TYR(9), TYRP1(6), WBSCR22(2)	30007730	403	161	360	150	124	80	46	98	54	1	0.576	1.000	1.000
282	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(13), ADCY4(14), ADCY6(13), ADCY8(30), CACNA1A(27), CACNA1B(36), GNAS(35), GNAT3(4), GNB1(3), GNB3(6), GNG3(1), GRM4(15), ITPR3(39), KCNB1(19), PDE1A(8), PLCB2(10), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(8), SCNN1B(7), SCNN1G(9), TAS1R1(12), TAS1R2(20), TAS2R1(4), TAS2R10(6), TAS2R13(9), TAS2R14(1), TAS2R16(5), TAS2R3(5), TAS2R38(6), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(3), TAS2R46(1), TAS2R5(2), TAS2R50(9), TAS2R60(3), TAS2R7(3), TAS2R8(8), TAS2R9(1), TRPM5(5)	27085932	430	161	403	148	163	55	45	97	69	1	0.406	1.000	1.000
283	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(5), BAD(1), BRAF(111), CREB1(3), CREB3(5), CREB5(5), DUSP4(6), DUSP6(6), DUSP9(9), EEF2K(10), GRB2(9), MAP2K1(10), MAP2K2(2), MAP3K8(4), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MOS(8), NFKB1(8), RAP1A(1), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), SHC1(13), SOS1(11), SOS2(15), TRAF3(10)	15323530	310	159	229	103	60	83	34	86	46	1	0.299	1.000	1.000
284	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(29), CARM1(3), CCND1(2), CREBBP(68), EP300(42), ERCC3(18), ESR1(20), GRIP1(12), GTF2A1(5), GTF2E1(13), GTF2F1(5), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), MEF2C(15), NCOR2(38), NR0B1(10), NRIP1(17), PELP1(11), POLR2A(12), SRA1(2), TBP(2)	23481084	379	157	340	172	102	76	40	68	93	0	0.998	1.000	1.000
285	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	61	ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), CDS1(13), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CHPT1(3), CRLS1(1), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), ESCO1(16), ESCO2(13), ETNK1(3), GNPAT(17), GPAM(4), GPD1(3), GPD1L(4), GPD2(10), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(28), MYST4(25), NAT6(2), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(11), SH3GLB1(5)	32739725	411	157	373	159	114	75	58	99	64	1	0.869	1.000	1.000
286	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CHEK1(10), MYT1(20), WEE1(15), YWHAH(3)	7312311	275	155	218	96	49	98	22	56	44	6	0.432	1.000	1.000
287	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AGK(6), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CEL(12), DAK(7), DGAT1(5), DGAT2(4), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), GK(5), GK2(13), GLA(7), GLB1(9), GPAM(4), LCT(39), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(12), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	29415673	404	154	375	150	111	64	60	124	44	1	0.546	1.000	1.000
288	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(6), AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PRIM1(5), PRIM2(2), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), TK1(2), TK2(2), TXNRD1(9), TXNRD2(8), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UPB1(7), UPP1(5), UPP2(4), UPRT(6)	42323224	484	153	466	149	127	84	77	122	74	0	0.0440	1.000	1.000
289	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), HSD3B7(3), NSD1(25), OGDH(13), OGDHL(12), PIPOX(8), PLOD1(7), PLOD2(9), PLOD3(6), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SETD1A(20), SETD7(7), SETDB1(18), SHMT1(6), SHMT2(5), SPCS1(2), SPCS3(2), SUV39H1(4), SUV39H2(6), TMLHE(3)	28796492	342	152	319	103	117	55	35	77	58	0	0.126	1.000	1.000
290	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), F10(5), F11(8), F12(5), F2(9), F2R(11), F5(30), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), PROC(3), PROS1(9), SERPINC1(8), SERPING1(5)	23443152	331	152	309	132	72	62	48	88	59	2	0.705	1.000	1.000
291	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(38), EGF(7), EGFR(104), GRB2(9), HRAS(4), MAP2K1(10), MAPK1(3), MAPK3(3), PTPRB(19), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SPRY1(9), SPRY2(2), SPRY4(7), SRC(3)	12353674	275	151	234	95	55	89	44	53	33	1	0.235	1.000	1.000
292	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHFR(1), DHX58(4), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), FPGS(4), GGH(1), IFIH1(20), MOV10L1(16), NUDT5(1), QDPR(2), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SKIV2L2(11), SMARCA2(19), SMARCA5(13), SPR(7)	31802044	417	149	375	138	132	77	48	86	72	2	0.370	1.000	1.000
293	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(8), ACOX1(11), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP4A11(7), CYP4A22(13), DCI(3), ECHS1(3), EHHADH(13), GCDH(6), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), PECI(2)	25360409	341	148	314	97	93	67	56	83	42	0	0.00463	1.000	1.000
294	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(12), CAPN1(2), CAPN2(8), CAPNS1(4), CAPNS2(4), CXCR3(4), EGF(7), EGFR(104), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTK2(24), PXN(2), TLN1(21)	17131857	282	148	262	114	66	82	45	59	29	1	0.625	1.000	1.000
295	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(10), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDK5(2), F2(9), FYN(15), GNA11(8), GNAI1(3), GNB1(3), GRB2(9), HRAS(4), JAK2(48), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MAPT(10), MYLK(29), PLCG1(17), PRKCA(5), PTK2B(13), RAF1(13), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), SYT1(14)	21253057	333	147	287	124	83	87	43	63	54	3	0.658	1.000	1.000
296	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	88	ANK2(71), B3GALT4(4), CDR1(5), DGKI(18), FAU(1), IL6ST(14), MRPL19(4), PIGK(10), RPL10(2), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(5), RPL6(2), RPL7(3), RPL7A(1), RPL8(3), RPL9(3), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(1), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS4X(1), RPS5(2), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), RPS7(1), RPS9(3), RPSA(1), SLC36A2(3), TSPAN9(4), UBA52(3), UBB(2), UBC(6)	25550442	318	147	301	93	81	65	44	77	49	2	0.196	1.000	1.000
297	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), BCR(11), CAPN1(2), CAPNS1(4), CAPNS2(4), CRKL(5), CSK(3), FYN(15), GRB2(9), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MAPK8(11), PPP1R12B(28), PTK2(24), PXN(2), RAF1(13), RAP1A(1), ROCK1(27), SHC1(13), SOS1(11), SRC(3), TLN1(21), VCL(9), ZYX(2)	23248636	313	146	262	113	90	56	36	59	66	6	0.694	1.000	1.000
298	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), RB1(123), RBL1(18), TFDP1(10)	8220397	237	145	188	88	41	74	20	59	35	8	0.500	1.000	1.000
299	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AKR1B1(3), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), CEL(12), DGAT1(5), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), GK(5), GLA(7), GLB1(9), LCT(39), LIPC(5), LIPF(1), LIPG(4), LPL(12), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PPAP2A(2), PPAP2B(2), PPAP2C(3)	23988620	355	145	326	120	97	65	54	99	39	1	0.179	1.000	1.000
300	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(28), ATP4A(17), ATP4B(3), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), COX10(6), COX15(5), COX17(1), COX4I1(5), COX4I2(3), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(5), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(2), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(7), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(3), NDUFC1(1), NDUFC2(2), NDUFS1(14), NDUFS2(3), NDUFS3(4), NDUFS4(1), NDUFS5(1), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(4), PPA1(3), PPA2(3), SDHA(12), SDHB(3), SDHD(4), TCIRG1(6), UQCRB(2), UQCRC1(4), UQCRC2(11), UQCRFS1(3), UQCRH(1)	29093293	387	144	354	115	126	77	46	67	71	0	0.0218	1.000	1.000
301	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(6), ABO(5), B3GALNT1(5), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(3), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALNT1(12), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT6(10), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GBGT1(1), GCNT2(24), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGX(2), PIGZ(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(12), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7), UGCG(9)	23580958	324	142	291	101	100	59	24	77	63	1	0.393	1.000	1.000
302	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTG2(6), ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), CDC42(2), CFL1(2), CFL2(2), FLNA(24), FLNC(36), FSCN1(5), FSCN3(5), GDI1(1), GDI2(2), LIMK1(7), MYH2(37), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PFN2(4), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), VASP(4), WASF1(3), WASL(16)	22575562	347	142	319	121	98	55	42	78	69	5	0.457	1.000	1.000
303	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ENPP1(17), ENPP3(10), G6PC(4), GAA(14), GANAB(12), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), MGAM(26), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), SI(24), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UXS1(8)	30561250	340	142	324	102	97	62	43	70	67	1	0.157	1.000	1.000
304	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPS(5), CDS1(13), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CLC(2), CPT1B(13), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), ETNK1(3), GNPAT(17), GPD1(3), GPD2(10), LCAT(4), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(6), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB2(10), PLCG1(17), PLCG2(23), PPAP2A(2), PPAP2B(2), PPAP2C(3)	24504695	330	141	300	121	103	51	47	77	52	0	0.649	1.000	1.000
305	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(6), ACSS2(9), ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), G6PC2(2), GALM(3), GAPDH(2), GAPDHS(3), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3)	29051054	355	141	324	121	114	64	38	84	55	0	0.323	1.000	1.000
306	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(22), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(4), GNAI1(3), GNAQ(10), GNAS(35), GNB1(3), HRAS(4), JUN(2), MAP2K1(10), MAPK3(3), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RAF1(13), RPS6KA3(13), SYT1(14)	16699581	244	139	207	85	96	61	23	34	30	0	0.202	1.000	1.000
307	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	33	AKT1(11), ATF1(5), CDC42(2), CREB1(3), CREB3(5), CREB5(5), DUSP1(6), DUSP10(5), EEF2K(10), ELK1(4), IL1R1(6), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K10(10), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MKNK1(2), MKNK2(6), MYEF2(14), NFKB1(8), NR2C2(11), SRF(4), TRAF6(4)	16863725	263	139	233	67	65	47	42	57	50	2	0.0113	1.000	1.000
308	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(23), BAD(1), BAX(14), BCL2(2), BCL2A1(2), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP9(5), CD40(6), CD40LG(10), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), IKBKE(8), LTA(1), NFKB1(8), NFKBIA(1), NGFR(4), NR3C1(8), NTRK1(16), PTPN13(20), RIPK1(7), SFRS2IP(3), TFG(8), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10), TRAF6(4)	21268624	257	138	225	129	58	63	24	55	56	1	1.000	1.000	1.000
309	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(8), ACAA1(7), ACAA2(2), ACADM(9), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), AOX1(12), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(3), ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HADHB(9), HIBADH(2), HIBCH(2), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), OXCT2(3), PCCA(11), PCCB(5)	22816079	281	138	256	67	84	53	35	56	52	1	0.00249	1.000	1.000
310	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG5(4), ALG6(5), ALG8(12), ALG9(7), B4GALT1(7), B4GALT2(7), B4GALT3(6), DAD1(3), DDOST(4), DHDDS(4), DPAGT1(12), DPM1(3), FUT8(10), GANAB(12), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), RFT1(3), RPN1(4), RPN2(6), ST6GAL1(3), STT3B(9)	21057619	289	137	261	95	74	52	32	74	57	0	0.684	1.000	1.000
311	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), DRD1(9), DRD2(7), DRD3(5), DRD5(10), HRH1(4), HRH2(15), HTR1A(15), HTR1B(11), HTR1D(4), HTR1E(15), HTR1F(9), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12)	12272501	272	137	239	93	112	56	33	41	29	1	0.0595	1.000	1.000
312	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	29	ACTR2(1), ACTR3(4), ARHGAP1(3), ARHGAP4(7), ARHGAP6(10), ARHGEF1(13), ARHGEF11(20), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), BAIAP2(6), CFL1(2), DIAPH1(7), GSN(4), LIMK1(7), MYL2(2), MYLK(29), OPHN1(7), PIP5K1A(7), PIP5K1B(3), PPP1R12B(28), ROCK1(27), SRC(3), TLN1(21), VCL(9)	22370648	248	136	213	83	74	36	24	52	57	5	0.747	1.000	1.000
313	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(11), AKT2(7), AKT3(7), ARHGEF11(20), BCL2(2), CDC42(2), DLG4(10), GNA13(3), IKBKG(2), LPA(28), MAP2K4(32), MAP3K1(18), MAP3K5(14), MAPK8(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PI3(2), PIK3CB(5), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RDX(13), ROCK1(27), ROCK2(15), SERPINA4(5), SRF(4)	24700855	334	136	307	102	93	54	37	83	61	6	0.290	1.000	1.000
314	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), AGMAT(3), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH4A1(7), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), MAOA(5), MAOB(6), NOS1(23), NOS3(21), OAT(3), ODC1(5), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(6), RARS(7), SMS(4)	22251610	305	135	276	96	102	57	41	60	45	0	0.126	1.000	1.000
315	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), CSK(3), CTNNA1(26), CTNNA2(33), CTNNB1(99), PTK2(24), PXN(2), SRC(3), VCL(9)	9322544	234	135	191	98	54	65	25	62	27	1	0.897	1.000	1.000
316	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(8), ACACA(30), ACACB(37), ACADM(9), ACAT1(7), ACAT2(8), ACSS1(6), ACSS2(9), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), HIBCH(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SUCLA2(6), SUCLG1(2), SUCLG2(1)	21024607	284	135	260	60	90	41	42	62	49	0	0.000418	1.000	1.000
317	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CREBBP(68), DUSP1(6), EP300(42), IKBKB(7), IL1B(4), IL8(5), MAP2K3(8), MAP2K6(4), MAP3K14(6), MAP3K7(7), MAPK14(7), MYD88(3), NFKB1(8), NFKBIA(1), NR3C1(8), RELA(9), TGFBR1(17), TGFBR2(24), TLR2(7), TNF(1)	14289776	242	135	218	96	67	69	31	44	30	1	0.688	1.000	1.000
318	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(6), CDC42(2), CREB1(3), DAXX(14), DDIT3(4), ELK1(4), GRB2(9), HRAS(4), HSPB2(2), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MYC(5), PLA2G4A(13), RAC1(2), RIPK1(7), RPS6KA5(10), SHC1(13), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8)	18692927	279	135	255	83	82	60	33	57	45	2	0.142	1.000	1.000
319	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3)	24638220	317	134	286	100	98	65	35	74	45	0	0.117	1.000	1.000
320	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3)	24638220	317	134	286	100	98	65	35	74	45	0	0.117	1.000	1.000
321	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(5), GTF2A1L(9), GTF2A2(1), GTF2B(11), GTF2E1(13), GTF2E2(1), GTF2F1(5), GTF2H1(4), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(16), TAF1(26), TAF10(1), TAF12(3), TAF13(3), TAF1L(50), TAF2(17), TAF4(9), TAF4B(9), TAF5(11), TAF5L(2), TAF6(8), TAF6L(5), TAF7(2), TAF7L(12), TAF9(2), TAF9B(1), TBPL1(3), TBPL2(2)	18917334	240	134	216	73	65	42	28	66	38	1	0.239	1.000	1.000
322	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), IL6(5), IL6R(7), IL6ST(14), JAK1(20), JAK2(48), JAK3(27), JUN(2), MAP2K1(10), MAPK3(3), PTPN11(31), RAF1(13), SHC1(13), SOS1(11), SRF(4), STAT3(10)	12176668	246	134	189	74	56	84	32	39	32	3	0.105	1.000	1.000
323	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(27), EEF1A2(8), EEF1B2(1), EEF1D(9), EEF1G(1), EEF2(7), EEF2K(10), EIF1AX(1), EIF2AK1(16), EIF2AK2(3), EIF2AK3(13), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF4A2(10), EIF4EBP2(3), EIF4G1(17), EIF4G3(16), EIF5(6), EIF5A(2), EIF5B(20), ETF1(10), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(16), PAIP1(4), SLC35A4(3)	22132645	276	134	240	71	61	64	28	57	66	0	0.0367	1.000	1.000
324	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), DBH(8), DCT(17), DDC(5), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HGD(5), HPD(6), MAOA(5), MAOB(6), PNMT(3), TAT(14), TPO(29), TYR(9)	15935467	238	134	206	82	83	45	27	56	27	0	0.201	1.000	1.000
325	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), ESCO1(16), ESCO2(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), PRDX6(4), SH3GLB1(5), TAT(14), TPO(29)	17599179	272	132	234	87	100	46	27	53	45	1	0.222	1.000	1.000
326	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(4), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(9), ASPA(6), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(11), HARS(6), HARS2(6), HDC(8), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), PRPS1(8), PRPS2(6), UROC1(7), WBSCR22(2)	19920970	268	131	246	74	76	57	36	64	35	0	0.0189	1.000	1.000
327	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), HIBADH(2), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), PCCA(11), PCCB(5), SDS(3)	18974195	268	131	243	57	77	50	37	59	44	1	0.000122	1.000	1.000
328	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	19	ADCY1(22), CD3D(4), CD3E(2), CD4(4), CREBBP(68), CSK(3), GNAS(35), GNB1(3), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12)	10916739	219	130	190	80	73	60	21	33	30	2	0.408	1.000	1.000
329	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(11), CALM2(1), CALM3(1), CD79A(6), CD79B(2), ELK1(4), FOS(4), GRB2(9), HRAS(4), JUN(2), LYN(13), MAP2K1(10), MAP3K1(18), MAPK14(7), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), RAC1(2), RAF1(13), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22)	19019390	261	130	233	82	81	58	33	47	41	1	0.155	1.000	1.000
330	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	19	ADCY1(22), CD3D(4), CD3E(2), CD4(4), CREBBP(68), CSK(3), GNAS(35), GNB1(3), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12)	10916739	219	130	190	80	73	60	21	33	30	2	0.408	1.000	1.000
331	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(10), AKR1D1(8), ARSD(9), ARSE(4), CARM1(3), CYP11B1(13), CYP11B2(7), CYP19A1(8), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), WBSCR22(2)	24978580	299	130	282	94	80	55	35	71	58	0	0.197	1.000	1.000
332	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(30), ACACB(37), ACAT1(7), ACAT2(8), ACOT12(8), ACSS1(6), ACSS2(9), ACYP1(1), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PCK2(6), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4)	24117785	317	130	292	98	98	55	43	68	53	0	0.150	1.000	1.000
333	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	65	CALR(1), CANX(5), CD4(4), CD74(3), CD8A(1), CD8B(4), CIITA(15), CREB1(3), CTSB(3), CTSL1(6), CTSS(4), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA2(4), HLA-DQB1(1), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), HSP90AA1(7), HSP90AB1(2), HSPA5(3), IFI30(3), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(9), KIR2DL4(5), KIR2DS4(4), KIR3DL1(6), KIR3DL2(6), KIR3DL3(10), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LGMN(1), LTA(1), NFYA(3), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(14), RFXANK(1), RFXAP(5), TAP1(7), TAP2(15), TAPBP(4)	20383577	292	130	273	94	51	60	39	74	57	11	0.382	1.000	1.000
334	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(13), AGT(10), EDN1(3), EDNRA(8), EDNRB(13), EGF(7), EGFR(104), FOS(4), HRAS(4), JUN(2), MYC(5), NFKB1(8), PLCG1(17), PRKCA(5), RELA(9)	10261101	212	129	191	91	43	63	37	43	26	0	0.857	1.000	1.000
335	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(8), ASPH(12), COPS5(1), CREB1(3), EDN1(3), EP300(42), EPO(1), HIF1A(14), JUN(2), LDHA(10), NOS3(21), P4HB(6), VHL(83)	8362614	206	129	164	79	31	76	28	38	33	0	0.651	1.000	1.000
336	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AACS(7), AADAC(5), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ACSM1(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH7A1(6), ALDH9A1(4), BDH1(3), BDH2(2), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADH(2), HADHA(10), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), HSD3B7(3), ILVBL(8), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(7), PDHA2(14), PDHB(3), PLA1A(8), PPME1(2), PRDX6(4), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	20428213	273	129	249	79	89	53	33	65	33	0	0.0203	1.000	1.000
337	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(8), ADC(3), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EARS2(3), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GFPT2(11), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GNPNAT1(1), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSR(5), GSS(8), NADSYN1(4), NAGK(7), PPAT(5), QARS(13)	19930868	253	128	235	67	71	52	33	66	31	0	0.0192	1.000	1.000
338	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(9), CFL1(2), GNAQ(10), GNAS(35), GNB1(3), HRAS(4), LIMK1(7), MAP2K1(10), MAPK1(3), MAPK3(3), MYL2(2), NOX1(4), PIK3C2G(19), PLCB1(22), PPP1R12B(28), PRKCA(5), PTK2(24), RAF1(13), ROCK2(15)	12760964	219	127	173	63	71	47	19	41	40	1	0.174	1.000	1.000
339	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(9), AARS2(13), CARS(10), CARS2(6), DARS(4), DARS2(7), EARS2(3), EPRS(23), FARS2(5), FARSA(6), FARSB(11), GARS(8), HARS(6), HARS2(6), IARS(9), IARS2(19), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), MTFMT(1), NARS(4), NARS2(8), PARS2(2), QARS(13), RARS(7), RARS2(7), SARS(5), SARS2(4), TARS(7), TARS2(9), VARS(7), VARS2(9), WARS(3), WARS2(6), YARS(4), YARS2(6)	27433192	289	127	282	69	95	40	38	71	45	0	0.00943	1.000	1.000
340	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	ALOX12(3), ALOX12B(4), ALOX15(4), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP2U1(5), CYP4A11(7), CYP4A22(13), CYP4F2(12), CYP4F3(10), DHRS4(1), EPHX2(5), GGT1(9), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11)	20069034	250	126	231	84	76	37	36	63	38	0	0.370	1.000	1.000
341	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(6), ADCY3(10), ADCY9(19), AK1(1), ARF1(1), ARF4(4), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ERO1L(3), GNAS(35), PDIA4(7), PLCG1(17), PLCG2(23), PRKCA(5), SEC61A1(9), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(13)	18845920	262	126	220	94	98	60	27	41	36	0	0.383	1.000	1.000
342	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ITPA(6), NME1(1), NT5C(1), NT5E(6), NT5M(3), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), RRM1(2), RRM2(5), TK1(2), TK2(2), TXNRD1(9), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UNG(3), UPB1(7), UPP1(5)	29198675	335	126	320	107	95	55	49	92	44	0	0.181	1.000	1.000
343	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(7), EGFR(104), MAP2K1(10), MAP3K1(18), MAPK14(7), NCOR2(38), RARA(5), RXRA(8), THRA(6), THRB(14)	8373926	217	124	191	80	52	61	33	41	30	0	0.577	1.000	1.000
344	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(6), ELK1(4), FOS(4), IKBKB(7), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), PPARA(7), RELA(9), TIRAP(5), TLR10(11), TLR2(7), TLR3(13), TLR4(15), TLR6(12), TLR7(15), TLR9(12), TOLLIP(5), TRAF6(4)	17816346	255	124	246	73	62	46	30	69	46	2	0.119	1.000	1.000
345	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(28), ATP4B(3), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ATP7A(11), ATP7B(14), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3), PPA2(3), SDHA(12), SDHB(3), SHMT1(6), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1)	20258705	258	123	234	84	83	44	33	47	51	0	0.187	1.000	1.000
346	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), CALM2(1), CALM3(1), CRKL(5), GNAQ(10), GRB2(9), HRAS(4), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), PAK1(10), PLCG1(17), PRKCA(5), PTK2B(13), RAC1(2), RAF1(13), SHC1(13), SOS1(11), SRC(3), SYT1(14)	14364955	232	123	203	79	54	51	30	60	35	2	0.517	1.000	1.000
347	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(4), AKT1(11), AKT2(7), AKT3(7), DAG1(8), GNAQ(10), IKBKG(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PIK3CB(5), PITX2(2), PLD1(16), PLD2(7), PLD3(7), VN1R1(7)	21502783	273	123	263	93	87	55	38	57	36	0	0.276	1.000	1.000
348	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(8), F12(5), F13B(10), F2(9), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), LPA(28), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8), SERPINF2(4), VWF(30)	18220608	283	122	259	109	68	53	42	72	45	3	0.740	1.000	1.000
349	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), ELK1(4), FPR1(5), GNA15(5), GNB1(3), HRAS(4), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NCF1(4), NCF2(8), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PAK1(10), PIK3C2G(19), PLCB1(22), PPP3CA(3), PPP3CB(10), PPP3CC(5), RAC1(2), RAF1(13), RELA(9), SYT1(14)	18933125	252	122	232	88	84	47	31	54	35	1	0.347	1.000	1.000
350	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(8), ACACA(30), ACADL(4), ACADM(9), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), LDHA(10), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SDS(3), SUCLA2(6), SUCLG1(2), SUCLG2(1)	17558286	255	122	230	52	77	42	38	55	43	0	0.000332	1.000	1.000
351	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(6), BCR(11), BLNK(1), ELK1(4), FOS(4), GRB2(9), HRAS(4), JUN(2), LYN(13), MAP2K1(10), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8IP3(11), PAPPA(33), RAC1(2), RPS6KA1(9), RPS6KA3(13), SHC1(13), SOS1(11), SYK(5), VAV1(22), VAV2(18)	14766475	225	122	201	63	70	47	31	49	27	1	0.0373	1.000	1.000
352	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(6), CDC7(23), CDK2(5), DIAPH2(24), GMNN(3), MCM10(10), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), PRIM1(5), RFC1(20), RFC2(2), RFC4(8), RFC5(6), RPA1(12), RPA2(1), RPA3(4), RPA4(5), UBA52(3), UBB(2), UBC(6)	25578550	297	121	260	95	57	52	40	75	72	1	0.529	1.000	1.000
353	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(7), ACAA2(2), ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1B10(3), AKR1C4(10), AKR1D1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), HSD3B7(3), LIPA(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SLC27A5(7), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2)	16332670	230	121	206	61	60	50	35	59	25	1	0.0109	1.000	1.000
354	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(8), AGXT2(8), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), ATP6V0C(1), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CPT1B(13), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), MAOA(5), MAOB(6), PEMT(2), PISD(5), PLCB2(10), PLCG1(17), PLCG2(23), PSPH(1), SARDH(15), SARS(5), SHMT1(6), SHMT2(5), TARS(7)	21297265	264	120	242	97	95	39	35	51	44	0	0.604	1.000	1.000
355	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(9), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(5), ADSSL1(6), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), ASRGL1(1), ASS1(4), CAD(20), CRAT(10), DARS(4), DARS2(7), DDO(6), DLAT(7), DLD(3), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), NARS2(8), PC(12), PDHA1(7), PDHA2(14), PDHB(3)	19177377	244	120	230	87	81	36	37	53	37	0	0.465	1.000	1.000
356	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(8), ABP1(4), ACADM(9), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), HIBCH(2), MLYCD(4), SMS(4), SRM(1), UPB1(7)	13882003	229	120	210	60	70	36	34	62	27	0	0.00838	1.000	1.000
357	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ATP6V0C(1), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADHA(10), PLOD1(7), PLOD2(9), PLOD3(6), SDS(3), SHMT1(6), SHMT2(5), TMLHE(3)	17869928	238	120	220	58	71	44	31	55	37	0	0.00204	1.000	1.000
358	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(30), ACAT1(7), ACAT2(8), ACYP1(1), ADH5(6), AKR1B1(3), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4)	18851796	268	120	241	83	78	55	36	58	41	0	0.138	1.000	1.000
359	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(26), GABBR1(16), GPRC5A(5), GPRC5B(3), GPRC5C(9), GPRC5D(3), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM7(30), GRM8(27)	10083260	224	119	193	88	92	30	27	44	31	0	0.620	1.000	1.000
360	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(4), BFAR(8), BRAF(111), CAMP(1), CREB1(3), CREB3(5), CREB5(5), MAPK1(3), RAF1(13), SRC(3), TERF2IP(3)	5157006	159	118	90	54	15	50	15	64	15	0	0.497	1.000	1.000
361	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(8), AGXT2(8), AKR1B10(3), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), GNMT(3), HSD3B7(3), MAOA(5), MAOB(6), PEMT(2), PHGDH(3), PIPOX(8), PISD(5), PSAT1(6), PSPH(1), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SARDH(15), SARS(5), SARS2(4), SDS(3), SHMT1(6), SHMT2(5), TARS(7), TARS2(9)	22029091	256	117	241	90	89	35	35	58	39	0	0.446	1.000	1.000
362	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(16), CCNE1(6), CDC34(2), CDK2(5), CUL1(16), RB1(123), SKP2(3), TFDP1(10)	4612671	181	117	133	64	31	63	10	43	26	8	0.387	1.000	1.000
363	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(7), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH9A1(4), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), L2HGDH(3), OXCT1(3), PDHA1(7), PDHA2(14), PDHB(3), SDHB(3), SDS(3)	13503680	219	116	197	52	65	43	31	53	27	0	0.00116	1.000	1.000
364	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(3), B4GALT1(7), B4GALT2(7), G6PC(4), G6PC2(2), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANC(8), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), HSD3B7(3), LALBA(1), LCT(39), MGAM(26), PFKL(7), PFKM(2), PFKP(15), PGM1(8), PGM3(5), RDH11(3), RDH12(6), RDH13(4), RDH14(1), UGP2(10)	18749746	246	116	235	87	87	40	30	61	28	0	0.343	1.000	1.000
365	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(9), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CYP2C19(11), CYP2C9(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), HADHA(10), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3)	15799361	237	116	211	71	64	52	30	53	37	1	0.153	1.000	1.000
366	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), PON1(11)	14763894	222	115	217	66	85	37	21	53	25	1	0.0786	1.000	1.000
367	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(8), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSS(8), NADSYN1(4), PPAT(5), QARS(13)	17216991	223	115	205	54	58	49	29	61	26	0	0.00919	1.000	1.000
368	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(7), EGFR(104), ERBB3(28), NRG1(26), UBE2D1(1)	5466473	166	114	140	57	38	59	23	32	14	0	0.266	1.000	1.000
369	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(5), CDKN1B(4), CKS1B(2), CUL1(16), RB1(123), SKP2(3), TFDP1(10), UBE2M(2)	4522685	171	114	125	60	26	61	10	37	29	8	0.473	1.000	1.000
370	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(4), GRB2(9), HRAS(4), JAK2(48), JUN(2), MAP2K1(10), MAPK3(3), MAPK8(11), PLCG1(17), PTPN6(4), RAF1(13), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19)	11083947	190	112	154	67	47	56	19	32	33	3	0.736	1.000	1.000
371	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(7), B4GALT2(7), FBP2(4), G6PC(4), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANAB(12), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), LALBA(1), LCT(39), MGAM(26), PFKM(2), PFKP(15), PGM1(8), PGM3(5)	15965997	215	112	207	80	74	40	26	50	25	0	0.538	1.000	1.000
372	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ACY1(5), ADC(3), AGMAT(3), ALDH18A1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), ASS1(4), CPS1(31), GATM(2), MAOA(5), MAOB(6), NAGS(5), ODC1(5), OTC(14), SAT1(4), SAT2(1), SMS(4), SRM(1)	15244572	203	112	180	60	60	47	27	46	23	0	0.0827	1.000	1.000
373	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(11), ALAS2(10), BLVRA(2), BLVRB(1), COX10(6), COX15(5), CP(18), CPOX(3), EARS2(3), EPRS(23), FECH(3), FTH1(1), FTMT(7), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), MMAB(1), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UROD(2), UROS(5)	21277127	250	112	225	63	57	47	32	62	52	0	0.0881	1.000	1.000
374	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(3), CREBBP(68), EP300(42), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RARA(5), RXRA(8)	10639166	168	111	157	77	41	45	25	30	27	0	0.927	1.000	1.000
375	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TAT(14), TPO(29)	11185665	183	111	157	49	78	27	18	33	27	0	0.0250	1.000	1.000
376	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), P4HB(6), SLC23A1(9), SLC23A2(17), SLC2A1(5), SLC2A3(12)	13422700	182	111	171	65	45	24	27	48	38	0	0.144	1.000	1.000
377	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), IL2(4), IL2RA(3), IL2RB(4), IL2RG(8), JAK1(20), JAK3(27), JUN(2), LCK(8), MAP2K1(10), MAPK3(3), MAPK8(11), RAF1(13), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19), SYK(5)	11939753	197	109	161	54	51	46	21	35	43	1	0.171	1.000	1.000
378	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(12), ADCY1(22), CAP1(4), CCNB1(8), CDC25C(5), GNAI1(3), GNAS(35), GNB1(3), HRAS(4), MAPK1(3), MAPK3(3), MYT1(20), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RPS6KA1(9), SRC(3)	10031512	161	109	142	48	73	32	18	26	12	0	0.0282	1.000	1.000
379	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), NOS1(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), SYT1(14)	12815583	197	109	183	90	67	40	15	42	33	0	0.935	1.000	1.000
380	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(3), ALOX15(4), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(10), EPX(13), GGT1(9), LPO(9), LTA4H(2), MPO(13), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11), TPO(29)	14105216	195	109	179	63	78	27	24	36	30	0	0.187	1.000	1.000
381	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(11), DLG4(10), EPHB2(15), F2(9), F2RL1(7), F2RL2(6), JUN(2), MAP2K5(4), MAPK1(3), MAPK7(6), MAPK8(11), MYEF2(14), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RAF1(13), RASAL1(7), SRC(3), TEC(8), VAV1(22)	14119161	205	109	188	78	69	47	27	38	24	0	0.597	1.000	1.000
382	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(12), AGT(10), AGTR1(12), CMA1(1), COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), REN(8)	13166602	176	107	171	58	41	26	25	47	37	0	0.0952	1.000	1.000
383	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(15), EGF(7), EGFR(104), HGS(10), RAB5A(3), TF(16), TFRC(5)	6691469	160	107	137	63	29	59	22	32	17	1	0.434	1.000	1.000
384	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GAPDHS(3), GCK(3), GOT1(6), GOT2(2), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6B(6), LDHB(5), LDHC(4), MDH1(8), MDH2(3), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PKLR(11), PKM2(4), TNFAIP1(4), TPI1(3)	20765388	233	107	217	98	91	38	23	47	34	0	0.857	1.000	1.000
385	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(10), POLA2(5), POLB(4), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLG(8), POLG2(4), POLH(13), POLK(9), POLM(11), POLQ(37), PRIM1(5), PRIM2(2), REV1(13), REV3L(36), RFC5(6)	21027386	240	107	220	77	54	38	32	65	50	1	0.582	1.000	1.000
386	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(10), BIRC2(5), BIRC3(11), CASP3(3), CFLAR(2), FADD(1), IKBKG(2), JUN(2), MAP2K4(32), MAP3K3(6), MAP3K7(7), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NR2C2(11), RALBP1(6), RIPK1(7), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	12371732	180	107	155	57	38	52	17	39	33	1	0.274	1.000	1.000
387	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(23), C5(20), C6(24), C7(10), ICAM1(4), IL1A(1), IL6(5), IL8(5), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELP(13), TNF(1), VCAM1(12)	12311973	178	106	170	62	58	27	20	38	34	1	0.336	1.000	1.000
388	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(68), EP300(42), LPL(12), NCOA1(13), NCOA2(21), PPARG(4), RXRA(8)	9283947	168	106	157	77	40	47	27	32	22	0	0.910	1.000	1.000
389	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CREBBP(68), EP300(42), FADD(1), HDAC3(3), IKBKB(7), IKBKG(2), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	10714589	158	106	146	69	43	46	20	24	25	0	0.852	1.000	1.000
390	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), DAG1(8), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFAT5(6), PDE6A(12), PDE6B(11), PDE6C(10), PDE6D(2), SLC6A13(9), TF(16)	17658234	238	106	234	84	75	43	28	51	41	0	0.328	1.000	1.000
391	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYB(2), NFYC(10), RB1(123), SP1(6), SP3(10)	3561443	154	106	109	50	18	64	10	34	20	8	0.114	1.000	1.000
392	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(2), ENPP7(2), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(5), SGMS2(6), SGPP1(6), SGPP2(4), SMPD1(9), SMPD2(3), SMPD3(4), SMPD4(8), SPHK1(2), SPHK2(5), SPTLC1(11), SPTLC2(9), UGCG(9), UGT8(10)	16365010	211	105	203	73	62	36	32	49	32	0	0.286	1.000	1.000
393	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CCR5(11), CD3D(4), CD3E(2), CXCR3(4), ETV5(13), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), JAK2(48), JUN(2), MAP2K6(4), MAPK14(7), MAPK8(11), STAT4(10), TYK2(5)	9541072	162	105	142	69	28	56	22	38	16	2	0.861	1.000	1.000
394	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(11), AZIN1(3), BTG1(2), CBX3(6), CLOCK(20), CRY1(13), CRY2(5), DNAJA1(4), EIF4G2(16), ETV6(10), GFRA1(12), GSTM3(5), GSTP1(1), HERPUD1(3), HSPA8(11), IDI1(4), KLF9(1), MYF6(6), NCKAP1(15), NCOA4(8), NR1D2(7), PER1(12), PER2(7), PIGF(1), PPP1R3C(4), PPP2CB(2), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(6), TUBB3(8), UCP3(3), UGP2(10), VAPA(2), ZFR(15)	18790421	238	103	199	68	68	37	22	53	56	2	0.334	1.000	1.000
395	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(7), ACAT2(8), ACOT11(9), ACYP1(1), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), FN3K(1), GCDH(6), HADHA(10), ITGB1BP3(1), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3)	13158598	178	103	161	60	47	35	23	38	34	1	0.477	1.000	1.000
396	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(5), ARSB(10), FUCA1(5), FUCA2(4), GALNS(6), GBA(4), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NAGLU(5), NEU1(6), NEU2(6), NEU3(2), SPAM1(9)	16510767	213	103	202	70	65	52	20	52	24	0	0.229	1.000	1.000
397	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(68), EP300(42), ESR1(20), MAPK1(3), MAPK3(3), PELP1(11), SRC(3)	7678049	150	103	140	68	40	38	19	29	24	0	0.920	1.000	1.000
398	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(48), JAK3(27), PIAS3(10), PTPRU(18), REG1A(6), SRC(3), STAT3(10)	7802819	156	103	131	56	45	51	22	19	17	2	0.491	1.000	1.000
399	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(12), EPHA4(20), EPHB1(33), FYN(15), ITGA1(12), ITGB1(12), L1CAM(14), LYN(13), RAP1B(2), SELP(13)	7982869	146	102	134	47	44	31	27	28	15	1	0.0971	1.000	1.000
400	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(8), CALCRL(7), CD97(10), CRHR1(4), CRHR2(5), ELTD1(11), EMR1(13), EMR2(7), GHRHR(2), GIPR(1), GLP1R(6), GLP2R(8), GPR64(17), LPHN1(19), LPHN2(26), LPHN3(26), SCTR(5), VIPR1(6), VIPR2(11)	13892229	196	102	192	84	61	31	19	60	25	0	0.849	1.000	1.000
401	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(12), ACO1(11), ACO2(7), CLYBL(6), CS(2), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), OGDHL(12), PC(12), PCK1(3), PCK2(6), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1)	14983809	160	102	151	54	55	22	26	35	22	0	0.274	1.000	1.000
402	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(7), ARG1(2), ARG2(5), ASL(3), ASS1(4), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), EPRS(23), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), LAP3(3), NOS1(23), NOS3(21), OAT(3), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(5), RARS(7), RARS2(7)	17466364	206	102	190	68	66	31	33	43	33	0	0.356	1.000	1.000
403	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(7), CDK7(3), ERCC3(18), GTF2A2(1), GTF2B(11), GTF2E1(13), GTF2E2(1), GTF2H1(4), GTF2H4(3), ILK(3), MNAT1(3), POLR1A(12), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3B(8), POLR3D(5), POLR3E(10), POLR3H(2), POLR3K(1), TAF12(3), TAF13(3), TAF5(11), TAF6(8), TAF7(2), TAF9(2), TBP(2)	18321761	183	102	169	73	47	33	26	41	36	0	0.888	1.000	1.000
404	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(4), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GCNT1(7), GCNT3(4), GCNT4(12), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(5)	16246956	208	101	200	88	66	30	29	52	31	0	0.960	1.000	1.000
405	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(13), FOS(4), GRB2(9), HRAS(4), IL3(6), JAK2(48), MAP2K1(10), MAPK3(3), PTPN6(4), RAF1(13), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19)	8659347	165	101	129	52	41	52	15	24	30	3	0.449	1.000	1.000
406	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(9), ABAT(8), ADSL(13), ADSS(5), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), CAD(20), CRAT(10), DARS(4), DDO(6), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), PC(12)	13176927	167	100	155	58	55	22	26	41	23	0	0.425	1.000	1.000
407	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(12), ACE2(12), AGT(10), AGTR1(12), ANPEP(16), CMA1(1), CPA3(4), CTSA(6), CTSG(4), ENPEP(22), LNPEP(21), MAS1(2), MME(23), NLN(10), REN(8), THOP1(6)	10428646	169	100	156	44	37	33	24	42	33	0	0.0452	1.000	1.000
408	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(10), ADRBK2(8), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CLCA1(12), CLCA2(8), CLCA4(14), CNGA3(14), CNGA4(13), CNGB1(15), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(2), PDC(4), PDE1C(17), PRKACA(1), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(10), PRKX(3)	16096741	196	100	190	91	56	30	28	50	32	0	0.960	1.000	1.000
409	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	IFNA1(7), IFNB1(6), IKBKB(7), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL1RN(6), IL6(5), IRAK1(6), IRAK2(11), IRAK3(9), JUN(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1), TOLLIP(5), TRAF6(4)	14135638	177	100	170	54	58	26	21	46	26	0	0.219	1.000	1.000
410	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	25	CALM2(1), CALM3(1), EGR2(14), EGR3(6), GNAQ(10), MAP3K1(18), MYC(5), NFATC2(10), NFKB1(8), NFKBIA(1), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), SYT1(14), VIP(3), VIPR2(11)	12624877	171	100	159	59	49	37	22	32	31	0	0.356	1.000	1.000
411	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(3), AKR1B10(3), ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), FUK(9), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), HSD3B7(3), KHK(4), LHPP(5), MPI(4), MTMR1(12), MTMR2(7), MTMR6(9), PFKFB1(12), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(7), PFKM(2), PFKP(15), PGM2(3), PHPT1(2), PMM1(3), PMM2(2), RDH11(3), RDH12(6), RDH13(4), RDH14(1), TPI1(3), TSTA3(1)	18393853	200	99	189	82	81	29	22	38	30	0	0.759	1.000	1.000
412	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(3), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(20), JAK2(48), JAK3(27), STAT1(15), STAT3(10), STAT5A(8), STAT5B(19), TYK2(5)	9227745	163	99	133	57	36	55	13	30	27	2	0.740	1.000	1.000
413	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(2), DLAT(7), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), PC(12), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PDK1(5), PDK2(8), PDK3(5), PDK4(4), PDP2(5), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1)	14714864	171	98	157	65	55	28	26	36	26	0	0.566	1.000	1.000
414	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(11), EEA1(15), GRASP(3), GSK3A(6), GSK3B(16), LYN(13), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PLCG1(17), PRKCE(4), PRKCZ(3), RAB5A(3), RAC1(2), RPS6KB1(9), VAV2(18)	12386375	172	98	156	51	52	37	25	28	29	1	0.117	1.000	1.000
415	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(9), F2R(11), GNAI1(3), GNB1(3), HRAS(4), ITGA1(12), ITGB1(12), MAP2K1(10), MAPK1(3), MAPK3(3), PLA2G4A(13), PLCB1(22), PRKCA(5), PTGS1(9), PTK2(24), RAF1(13), SRC(3), SYK(5), TBXAS1(11)	12718081	175	98	157	74	60	40	26	34	15	0	0.774	1.000	1.000
416	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(12), ITGB3(12), PTK2(24), PXN(2), RAC1(2), SPTAN1(25), SRC(3), TLN1(21)	14529895	165	98	159	88	52	30	19	40	22	2	0.998	1.000	1.000
417	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(4), CSF1R(15), DDX20(6), E2F4(2), ETS1(6), ETS2(4), ETV3(4), FOS(4), HDAC2(8), HDAC5(13), HRAS(4), JUN(2), NCOR2(38), RBL1(18), RBL2(22), SIN3A(20), SIN3B(9)	12922974	179	97	160	69	46	33	17	35	48	0	0.892	1.000	1.000
418	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(11), BAIAP2(6), CASP1(6), CASP3(3), CASP7(3), GAPDH(2), INSR(20), ITCH(7), MAGI1(27), MAGI2(25), RERE(15), WWP1(18), WWP2(8)	11414709	151	97	141	63	46	24	24	32	24	1	0.849	1.000	1.000
419	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(20), JAK2(48), JAK3(27), PIAS1(4), PIAS3(10), PTPRU(18), REG1A(6), SOAT1(6)	6928175	141	97	120	50	39	50	16	17	17	2	0.478	1.000	1.000
420	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(10), AKR1D1(8), ARSB(10), ARSD(9), ARSE(4), CYP11B1(13), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9)	14024603	178	96	160	50	64	28	20	29	37	0	0.0432	1.000	1.000
421	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C8B(22), C9(11), MASP1(19)	12608648	173	96	161	59	50	22	21	39	39	2	0.662	1.000	1.000
422	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BAX(14), BCL2(2), CYCS(1), FADD(1), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFKB1(8), NSMAF(10), RAF1(13), RELA(9), RIPK1(7), SMPD1(9), TNFRSF1A(4), TRAF2(8)	9819588	164	95	139	46	51	30	20	31	30	2	0.0830	1.000	1.000
423	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5)	12636124	170	95	152	66	38	41	23	42	25	1	0.747	1.000	1.000
424	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(22), CALM2(1), CALM3(1), CAPN2(8), CAPNS1(4), CAPNS2(4), EP300(42), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(10), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SYT1(14)	11515991	145	95	132	65	39	31	21	26	28	0	0.911	1.000	1.000
425	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(5), CASP2(8), CRADD(3), IKBKB(7), IKBKG(2), JUN(2), LTA(1), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP4K2(5), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNF(1), TNFRSF1A(4), TRAF2(8)	11296633	162	94	151	59	43	34	24	33	27	1	0.479	1.000	1.000
426	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	29	APAF1(23), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CFLAR(2), CYCS(1), DFFA(4), DFFB(2), FADD(1), GAS2(4), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), SPTAN1(25), TNFRSF10A(8), TNFRSF10B(4), TNFRSF25(2), TNFSF10(2), TNFSF12(2), TRAF2(8)	15595846	159	93	144	66	37	36	19	39	27	1	0.917	1.000	1.000
427	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(5), DAB1(13), FYN(15), LRP8(1), RELN(83), VLDLR(13)	7325732	132	93	109	41	35	35	16	27	19	0	0.0713	1.000	1.000
428	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(66), MAP2(51), PPP1CA(2), PPP2CA(3), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4), PRKCE(4)	9497583	149	92	132	48	30	33	20	33	33	0	0.402	1.000	1.000
429	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	FADD(1), IKBKB(7), IKBKG(2), IL1A(1), IL1R1(6), IRAK1(6), MAP3K1(18), MAP3K14(6), MAP3K7(7), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TLR4(15), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	11340662	146	92	138	51	34	40	16	31	25	0	0.449	1.000	1.000
430	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(39), APOA1(3), APOA4(4), APOC2(1), APOE(1), CETP(11), CYP7A1(13), DGAT1(5), HMGCR(6), LCAT(4), LDLR(9), LIPC(5), LPL(12), LRP1(49), SCARB1(3), SOAT1(6)	13528722	171	92	161	64	55	29	23	43	21	0	0.571	1.000	1.000
431	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(9), CARS(10), DARS(4), EPRS(23), FARS2(5), GARS(8), HARS(6), IARS(9), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), NARS(4), QARS(13), RARS(7), SARS(5), TARS(7), WARS(3), WARS2(6), YARS(4)	17070398	165	91	160	36	54	23	25	40	23	0	0.0126	1.000	1.000
432	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(10), CHIT1(10), CMAS(6), CTBS(6), CYB5R1(2), CYB5R3(1), GFPT1(5), GFPT2(11), GNE(7), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NAGK(7), NANS(1), NPL(3), PGM3(5), PHPT1(2), RENBP(3), UAP1(6)	14792435	170	91	164	47	61	33	19	32	25	0	0.0594	1.000	1.000
433	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(13), GLI2(22), GLI3(37), GSK3B(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SHH(3), SMO(11), SUFU(5)	7885736	140	91	129	62	54	30	13	21	22	0	0.725	1.000	1.000
434	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), LTA(1), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNFAIP3(39), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10)	10847205	148	91	135	51	38	42	17	22	29	0	0.310	1.000	1.000
435	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(22), GNAS(35), GNB1(3), PPP2CA(3), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	7641659	129	90	110	41	54	26	8	22	19	0	0.245	1.000	1.000
436	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11), MASP1(19), MASP2(10), MBL2(3)	12875350	164	90	153	60	45	18	21	38	40	2	0.820	1.000	1.000
437	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(18), GTF2A1(5), GTF2B(11), GTF2E1(13), GTF2F1(5), HDAC3(3), NCOA1(13), NCOA2(21), NCOA3(14), NCOR2(38), POLR2A(12), RARA(5), RXRA(8), TBP(2)	12246646	168	90	148	77	50	27	26	30	35	0	0.983	1.000	1.000
438	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(13), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPHN(16), NSF(4), SRC(3), UBQLN1(6)	6376004	134	88	124	46	33	20	14	43	24	0	0.468	1.000	1.000
439	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(7), AMD1(3), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTAP(2), MTFMT(1), MTR(13), SRM(1), TAT(14)	10647886	142	88	131	48	54	21	18	25	23	1	0.343	1.000	1.000
440	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG3(2), ATG5(9), ATG7(1), BECN1(2), GABARAPL1(1), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(25), PIK3R4(20), PRKAA1(8), PRKAA2(15), ULK2(14), ULK3(3)	10052417	147	88	131	41	23	37	22	44	20	1	0.163	1.000	1.000
441	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	12	ARHGEF1(13), GNA12(6), GNA13(3), GNAQ(10), GNB1(3), MYL2(2), MYLK(29), PLCB1(22), PPP1R12B(28), PRKCA(5), ROCK1(27)	9348231	148	88	117	51	33	25	14	30	42	4	0.833	1.000	1.000
442	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(20), JAK2(48), JAK3(27), MAPK1(3), MAPK3(3), STAT3(10), TYK2(5)	5905510	116	88	93	42	27	50	9	17	11	2	0.658	1.000	1.000
443	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), BLVRB(1), CP(18), CPOX(3), EPRS(23), FECH(3), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UROD(2), UROS(5)	14137647	148	87	129	41	38	26	18	30	36	0	0.343	1.000	1.000
444	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	16	CALM2(1), CALM3(1), CDKN1A(2), GNAQ(10), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SP1(6), SP3(10), SYT1(14)	9788005	118	86	107	53	32	30	13	23	20	0	0.909	1.000	1.000
445	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(7), CARM1(3), CBS(3), CTH(5), GGT1(9), HEMK1(1), LCMT1(1), LCMT2(6), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), METTL2B(2), METTL6(5), PAPSS1(4), PAPSS2(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SCLY(11), SEPHS1(5), SEPHS2(5), WBSCR22(2)	12430794	140	86	132	44	37	23	19	34	27	0	0.258	1.000	1.000
446	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(9), SMPD2(3), SPTLC1(11), SPTLC2(9), UGCG(9)	11380855	154	85	146	52	45	27	21	42	19	0	0.317	1.000	1.000
447	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(4), ALOX5(12), CYP1A2(10), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), HSD3B7(3), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	12588066	151	85	145	53	50	33	18	38	11	1	0.306	1.000	1.000
448	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), B4GALNT1(12), GLB1(9), HEXA(3), HEXB(3), LCT(39), SLC33A1(9), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7)	8467596	131	85	113	42	45	30	12	25	19	0	0.317	1.000	1.000
449	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(11), GRB2(9), IL2RG(8), IL4(5), IL4R(6), IRS1(17), JAK1(20), JAK3(27), RPS6KB1(9), SHC1(13), STAT6(4)	7166386	129	85	102	33	32	29	17	17	33	1	0.162	1.000	1.000
450	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(22), ADRB2(3), GNAS(35), PLCE1(32), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RAP2B(2)	7145289	119	85	102	30	49	28	7	23	12	0	0.0182	1.000	1.000
451	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(23), ARHGDIB(5), BIRC2(5), BIRC3(11), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP9(5), CYCS(1), DFFA(4), DFFB(2), GZMB(4), LMNB1(9), LMNB2(2), PRF1(7)	9297126	115	84	99	50	23	30	8	33	21	0	0.970	1.000	1.000
452	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(5), CSNK1D(14), DRD1(9), DRD2(7), GRM1(32), PLCB1(22), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	8141009	125	84	113	46	40	32	7	27	19	0	0.566	1.000	1.000
453	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(5), ABP1(4), AOC2(12), AOC3(9), CES1(13), ESCO1(16), ESCO2(13), LIPA(3), MYST3(28), MYST4(25), NAT6(2), PLA1A(8), PNPLA3(6), PPME1(2), PRDX6(4), SH3GLB1(5)	12297191	155	84	142	61	43	29	19	36	27	1	0.773	1.000	1.000
454	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(4), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), DDOST(4), DPAGT1(12), DPM1(3), FUT8(10), MAN1A1(12), MAN1B1(7), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), RPN1(4), RPN2(6), ST6GAL1(3)	9567334	136	84	122	43	39	29	17	27	24	0	0.499	1.000	1.000
455	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(10), F13A1(12), F2(9), F2R(11), FGA(19), FGB(4), FGG(7), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8)	7190582	128	83	120	52	31	23	22	31	21	0	0.838	1.000	1.000
456	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR7(5), CD28(4), CD4(4), CXCR3(4), CXCR4(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18R1(13), IL2(4), IL4(5), IL4R(6), TGFB1(2), TGFB2(6), TGFB3(2)	10650676	133	83	123	57	28	30	17	39	18	1	0.850	1.000	1.000
457	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(5), CREBBP(68), DFFA(4), DFFB(2), GZMA(8), GZMB(4), HMGB2(2), NME1(1), PRF1(7), SET(6)	5419971	108	83	103	46	29	25	14	23	17	0	0.796	1.000	1.000
458	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(11), ACO2(7), CS(2), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), PC(12), PCK1(3), SDHA(12), SDHB(3), SUCLA2(6), SUCLG1(2), SUCLG2(1)	10145375	107	82	100	40	34	16	17	24	16	0	0.501	1.000	1.000
459	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), XYLB(6)	13427435	161	82	145	42	31	26	19	43	42	0	0.281	1.000	1.000
460	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), HDAC5(13), MEF2A(5), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(3), PPP3CB(10), PPP3CC(5), SLC2A4(7), SYT1(14), YWHAH(3)	10100698	131	82	122	62	42	29	10	27	23	0	0.947	1.000	1.000
461	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), TNFAIP3(39), TRAF3(10), TRAF6(4)	8778194	125	81	115	40	31	34	13	21	26	0	0.288	1.000	1.000
462	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(11), CD2(7), CD3D(4), CD3E(2), CD4(4), CXCR3(4), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), JAK2(48), STAT4(10), TYK2(5)	7532899	120	81	103	49	16	46	17	28	11	2	0.792	1.000	1.000
463	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(5), IL13RA2(15), IL4R(6), JAK1(20), JAK2(48), TYK2(5)	5365235	101	81	81	35	19	50	3	19	8	2	0.495	1.000	1.000
464	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(5), IL13RA2(15), IL4R(6), JAK1(20), JAK2(48), TYK2(5)	5365235	101	81	81	35	19	50	3	19	8	2	0.495	1.000	1.000
465	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(22), ADRB2(3), CFTR(16), GNAS(35), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SLC9A3R1(3)	6371757	104	80	87	30	43	24	4	21	12	0	0.108	1.000	1.000
466	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(3), IFNGR1(6), JAK1(20), JAK2(48), PTPRU(18), REG1A(6), STAT1(15)	5980444	118	80	102	39	31	44	7	19	14	3	0.472	1.000	1.000
467	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(4), CR1(19), CR2(20), FCGR2B(2), HLA-DRB1(6), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27)	7317534	116	79	113	40	29	16	20	25	24	2	0.559	1.000	1.000
468	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(16), CD2(7), CD33(2), CD5(7), CD7(4), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(16), TLR2(7), TLR4(15), TLR7(15), TLR9(12)	9572799	133	79	123	55	43	22	16	37	13	2	0.696	1.000	1.000
469	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), NAGLU(5), SPAM1(9)	10144481	141	79	130	44	43	33	12	36	17	0	0.228	1.000	1.000
470	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), GLCE(5), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), NDST1(9), NDST2(9), NDST3(15), NDST4(13)	10448192	128	78	125	48	51	24	13	24	16	0	0.608	1.000	1.000
471	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	23	AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11)	10592944	123	78	116	48	38	23	17	23	22	0	0.775	1.000	1.000
472	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(2), ALDOC(1), DERA(4), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKL(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1(8), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TALDO1(4), TKT(6), TKTL1(7), TKTL2(12)	11501431	135	77	127	50	48	20	23	31	13	0	0.367	1.000	1.000
473	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), SELE(11), SELL(5), SELP(13)	8115760	111	77	110	36	38	20	11	23	19	0	0.271	1.000	1.000
474	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11)	9972928	120	77	113	45	36	23	17	23	21	0	0.712	1.000	1.000
475	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(3), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(5), EDN1(3), EDNRA(8), EDNRB(13), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(13), PRL(3), PTGDR(7), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11)	10734350	138	77	132	49	50	17	12	39	20	0	0.492	1.000	1.000
476	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2)	9737081	122	76	118	43	38	32	14	28	10	0	0.357	1.000	1.000
477	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(1), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), ILVBL(8), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7), VNN1(11)	8538602	128	76	121	34	28	26	23	37	13	1	0.0420	1.000	1.000
478	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(7), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTR(13)	9000806	121	76	114	38	45	20	13	21	21	1	0.276	1.000	1.000
479	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(3), CHAT(16), DBH(8), DDC(5), GAD1(15), GAD2(15), HDC(8), MAOA(5), PAH(15), PNMT(3), SLC18A3(11), TPH1(2)	6821903	108	75	100	45	37	18	11	34	8	0	0.649	1.000	1.000
480	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(8), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(14), JAK2(48), NFKB1(8), NFKBIA(1), RELA(9), SOD2(4)	6518410	102	75	89	37	19	39	12	17	13	2	0.488	1.000	1.000
481	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME3(7), PGK1(3), PGK2(9), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TKTL1(7), TKTL2(12), TPI1(3)	9839141	118	75	114	41	34	15	16	38	15	0	0.429	1.000	1.000
482	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(18), AP2A1(5), AP2M1(6), BIN1(3), CALM2(1), CALM3(1), DNM1(13), EPN1(9), EPS15(11), NME1(1), PICALM(8), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYNJ1(24), SYNJ2(14), SYT1(14)	11587367	146	75	133	62	38	27	16	36	29	0	0.865	1.000	1.000
483	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11)	10836621	132	74	121	44	37	13	16	27	37	2	0.729	1.000	1.000
484	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(9), F2R(11), F3(1), F5(30), F7(6), FGA(19), FGB(4), FGG(7), PROC(3), PROS1(9), SERPINC1(8), TFPI(6)	8417194	118	74	110	46	31	24	17	32	14	0	0.738	1.000	1.000
485	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	24	AKR1B1(3), ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), GCK(3), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), KHK(4), MPI(4), PFKFB1(12), PFKFB3(2), PFKFB4(5), PFKM(2), PFKP(15), PMM1(3), PMM2(2), TPI1(3)	11894894	123	74	116	53	49	18	13	24	19	0	0.808	1.000	1.000
486	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AGPS(5), CHPT1(3), ENPP2(23), ENPP6(10), PAFAH1B1(6), PAFAH2(6), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PPAP2A(2), PPAP2B(2), PPAP2C(3)	12152391	136	74	128	61	44	27	17	32	16	0	0.944	1.000	1.000
487	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(12), BST1(2), C9orf95(2), CD38(4), ENPP1(17), ENPP3(10), NADK(5), NADSYN1(4), NMNAT1(2), NMNAT2(4), NMNAT3(4), NNMT(4), NNT(5), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT12(3), QPRT(2)	11397771	123	73	117	42	37	26	16	29	14	1	0.219	1.000	1.000
488	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(23), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP7(3), CASP9(5), DFFA(4), DFFB(2), GZMB(4), PRF1(7), SCAP(6), SREBF1(8), SREBF2(9)	8241392	97	73	85	43	24	18	10	28	17	0	0.936	1.000	1.000
489	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(6), FOS(4), GNAQ(10), JUN(2), MAPK14(7), MAPK8(11), PLCG1(17), PRKCA(5), PTK2B(13), SYT1(14)	7104158	105	72	95	46	21	27	9	31	17	0	0.953	1.000	1.000
490	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CMBL(1), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), PON1(11), PON2(6), PON3(10)	8728048	124	72	115	40	33	29	13	28	20	1	0.310	1.000	1.000
491	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PGK1(3), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TPI1(3)	8714284	99	71	95	32	25	14	14	32	14	0	0.329	1.000	1.000
492	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(12), PGAP1(11), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGW(2), PIGX(2), PIGZ(6)	12374706	111	71	103	48	18	28	9	33	23	0	0.954	1.000	1.000
493	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5)	8323582	116	71	102	46	29	26	12	26	22	1	0.850	1.000	1.000
494	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(20), ABCC2(18), ABCG2(12), CES1(13), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9)	11602723	133	71	116	49	39	24	17	26	26	1	0.598	1.000	1.000
495	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(9), ACADS(3), ACADVL(6), ACSL1(9), ACSL3(11), ACSL4(10), CPT1A(10), CPT2(2), DCI(3), EHHADH(13), HADHA(10), SCP2(6), SLC25A20(1)	8818945	97	71	90	36	25	18	14	25	15	0	0.483	1.000	1.000
496	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	22	ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1(8), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TAL1(2), TALDO1(4), TKT(6)	9688831	107	71	99	41	37	17	15	28	10	0	0.523	1.000	1.000
497	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	16	ATF2(6), IFNG(3), IKBKB(7), IL2(4), IL4(5), JUN(2), MAP3K1(18), MAP3K5(14), MAP4K5(4), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), TNFRSF9(9), TRAF2(8)	9268684	116	70	108	29	33	28	13	27	15	0	0.0592	1.000	1.000
498	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), NCKAP1(15), NTRK1(16), PIR(1), PSMA7(1), RAC1(2), WASF1(3), WASF2(5), WASF3(14), WASL(16)	8126706	111	70	105	38	30	13	16	32	20	0	0.534	1.000	1.000
499	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(6), IFNGR2(4), JAK1(20), JAK2(48), STAT1(15)	4405562	96	70	81	34	20	41	3	19	10	3	0.571	1.000	1.000
500	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(1), IARS(9), IARS2(19), ILVBL(8), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3), VARS(7), VARS2(9)	8561493	99	69	98	34	39	17	14	14	15	0	0.478	1.000	1.000
501	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2)	7949587	105	69	101	31	31	28	13	23	10	0	0.131	1.000	1.000
502	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(5), ALDH18A1(8), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), GAMT(6), GATM(2), GLUD1(4), NAGS(5), OAT(3), ODC1(5), OTC(14), SMS(4)	8948451	111	69	103	32	29	26	19	24	13	0	0.125	1.000	1.000
503	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(8), FOS(4), HRAS(4), JUN(2), MAP2K1(10), MAPK1(3), MAPK3(3), MYC(5), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RAF1(13), RELA(9), TNF(1)	7829244	98	68	88	38	30	18	19	17	14	0	0.528	1.000	1.000
504	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), CHST1(9), CHST2(11), CHST4(6), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	5473752	92	68	88	31	45	17	4	14	12	0	0.516	1.000	1.000
505	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(23), BAK1(2), BAX(14), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(5), BIRC3(11), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CYCS(1), DFFA(4), DFFB(2), DIABLO(3), ENDOG(3)	6446899	87	68	67	30	16	14	10	23	23	1	0.849	1.000	1.000
506	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	13	MAP3K14(6), MAPK14(7), MAPK8(11), NFKB1(8), RELA(9), TNFRSF13B(6), TNFRSF17(4), TNFSF13(2), TNFSF13B(3), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4)	6534453	89	68	83	29	33	15	8	15	18	0	0.450	1.000	1.000
507	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(20), CLTA(5), CLTB(2), COPA(13), GBF1(17), GPLD1(12), KDELR1(5), KDELR2(8), KDELR3(2)	8562888	96	67	93	35	25	19	13	19	20	0	0.725	1.000	1.000
508	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(29), ABCB11(19), ABCB4(23), ABCC1(20), ABCC3(10), GSTP1(1)	7369488	102	67	105	33	18	16	16	27	23	2	0.536	1.000	1.000
509	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), FDXR(5), SHMT1(6)	8410255	103	67	88	39	31	24	12	17	19	0	0.717	1.000	1.000
510	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(23), C5(20), C6(24), C7(10), C8A(11), C9(11)	6634264	99	66	91	32	30	11	13	22	22	1	0.456	1.000	1.000
511	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	8056795	98	66	83	38	30	23	12	15	18	0	0.755	1.000	1.000
512	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(56), NRG2(6), NRG3(14), PRKCA(5), PSEN1(3)	4774191	95	66	88	36	17	21	18	25	14	0	0.678	1.000	1.000
513	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	8056795	98	66	83	38	30	23	12	15	18	0	0.755	1.000	1.000
514	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	8056795	98	66	83	38	30	23	12	15	18	0	0.755	1.000	1.000
515	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), IDS(5), LCT(39), NAGLU(5)	7169816	92	65	86	30	34	19	8	22	9	0	0.218	1.000	1.000
516	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELE(11), SELL(5)	6237051	85	65	82	32	26	16	7	18	18	0	0.635	1.000	1.000
517	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(20), ESR2(8), ITPKA(3), PDE1A(8), PDE1B(10), PLCB1(22), PLCB2(10), PRL(3), TRH(7), VIP(3)	5653105	94	65	87	34	27	17	13	21	16	0	0.561	1.000	1.000
518	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	8	CD3D(4), CD3E(2), CD4(4), FYN(15), HLA-DRB1(6), LCK(8), PTPRC(27), ZAP70(12)	4220464	78	65	66	26	19	17	12	11	17	2	0.348	1.000	1.000
519	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(4), LCT(39), MPI(4), PGM1(8), PYGL(6), PYGM(10), TPI1(3), TREH(6)	6970708	93	64	87	29	26	20	15	26	6	0	0.155	1.000	1.000
520	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), PHPT1(2), RFK(1), TYR(9)	7930988	108	64	97	31	30	29	12	20	16	1	0.160	1.000	1.000
521	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1)	12162862	101	64	98	28	28	15	22	20	16	0	0.158	1.000	1.000
522	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(12), APAF1(23), BCL2(2), CASP3(3), CASP9(5), CYCS(1), DAXX(14), FAS(7), FASLG(3), HSPB2(2), IL1A(1), MAPKAPK2(4), MAPKAPK3(6), TNF(1)	5583459	84	64	70	36	17	22	11	13	21	0	0.926	1.000	1.000
523	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(35), GNB1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5)	4744985	72	63	58	30	32	18	2	10	10	0	0.661	1.000	1.000
524	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(3), ALOX15(4), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(2), GGT1(9), LTA4H(2), PLA2G6(8), PTGDS(2), PTGES(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11)	7445767	90	63	84	35	28	11	12	21	18	0	0.683	1.000	1.000
525	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(1), MRPL13(6), MRPS7(4), RPL10A(2), RPL10L(4), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(2), RPL7(3), RPL8(3), RPL9(3), RPS10(2), RPS11(2), RPS13(2), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS5(2), RPS6(2), RPS7(1), RPS9(3), RPSA(1)	10355172	103	63	99	28	27	23	16	24	13	0	0.220	1.000	1.000
526	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(4), CSF3(2), HLA-DRB1(6), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL11(6), IL12A(1), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), LTA(1), PDGFA(2), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1)	6544903	87	63	79	39	26	16	7	24	11	3	0.895	1.000	1.000
527	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(30), CPT1A(10), LEP(1), LEPR(15), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6)	7781487	97	63	94	28	29	9	11	31	17	0	0.426	1.000	1.000
528	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37)	8638137	106	62	93	33	34	13	17	27	15	0	0.324	1.000	1.000
529	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(2), ATIC(13), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4)	9719681	94	62	88	45	29	14	14	19	16	2	0.951	1.000	1.000
530	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(2), BNIP1(5), GOSR1(4), GOSR2(5), SEC22B(3), SNAP23(2), SNAP25(1), SNAP29(4), STX11(6), STX12(6), STX16(7), STX17(1), STX18(2), STX19(3), STX2(5), STX3(3), STX4(3), STX5(10), STX6(2), STX7(3), STX8(5), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(3), VAMP4(3), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1)	8341316	108	62	96	31	34	11	11	22	30	0	0.435	1.000	1.000
531	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(6), B3GAT2(1), B3GAT3(1), B4GALT7(2), CHPF(10), CHST11(4), CHST12(4), CHST14(1), CHST3(6), CHSY1(14), DSE(9), UST(10), XYLT1(12), XYLT2(15)	6473794	95	61	78	42	35	13	12	16	18	1	0.889	1.000	1.000
532	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(4), CD3D(4), CD3E(2), IFNG(3), IL2(4), IL2RA(3), IL4(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14), TOB1(6), TOB2(2)	5425871	98	61	84	36	33	24	10	18	13	0	0.523	1.000	1.000
533	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(5), FDFT1(3), FDPS(6), GGCX(8), GGPS1(4), HMGCR(6), IDI1(4), IDI2(3), LSS(4), MVD(3), MVK(16), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1), TM7SF2(2)	9743490	96	60	85	33	27	8	13	23	25	0	0.764	1.000	1.000
534	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(15), PSMD11(8), PSMD12(4), PSMD13(6), PSMD2(3), PSMD6(5)	8627918	81	59	76	36	20	21	11	18	11	0	0.897	1.000	1.000
535	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(2), ATIC(13), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4)	9430955	89	59	82	43	26	15	13	18	15	2	0.949	1.000	1.000
536	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(4), CD3D(4), CD3E(2), CD4(4), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27)	5619971	86	59	81	35	22	14	13	18	19	0	0.787	1.000	1.000
537	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(10), FOS(4), JUN(2), MAPK3(3), OPRK1(12), POLR2A(12), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	6640353	71	58	68	19	26	13	5	12	15	0	0.155	1.000	1.000
538	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2)	7099195	77	58	77	30	15	19	8	24	11	0	0.782	1.000	1.000
539	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9)	8920638	89	58	75	27	25	13	11	12	28	0	0.538	1.000	1.000
540	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(6), JAK1(20), PTPRU(18), REG1A(6), STAT1(15), STAT2(10), TYK2(5)	6410913	87	58	81	21	30	20	8	16	13	0	0.0846	1.000	1.000
541	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(6), CYB5R3(1), GCK(3), GFPT1(5), GNE(7), GNPDA1(2), GNPDA2(3), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), PGM3(5), RENBP(3), UAP1(6)	8750177	83	57	80	29	26	21	8	17	11	0	0.525	1.000	1.000
542	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(4), GALNT10(8), GALNT2(10), GALNT3(15), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GCNT1(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4)	6850435	79	57	77	37	29	15	12	9	14	0	0.881	1.000	1.000
543	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(4), CD3D(4), CD3E(2), CD8A(1), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27)	5275922	83	57	78	33	23	14	11	17	18	0	0.740	1.000	1.000
544	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(4), CD86(2), HLA-DRB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), IL2(4), IL2RA(3), IL4(5), IL4R(6)	6326465	81	57	74	30	18	15	10	22	13	3	0.626	1.000	1.000
545	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CAMKK1(2), CAMKK2(8), CREB1(3), SYT1(14)	5920553	73	56	65	36	20	19	7	14	13	0	0.941	1.000	1.000
546	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL15(1), IL16(14), IL18(3), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL8(5), IL9(1), LTA(1), TNF(1)	5013721	68	55	61	36	20	15	6	20	7	0	0.931	1.000	1.000
547	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), NAT1(1), NAT2(3), XDH(19)	4269526	68	55	64	30	22	13	9	18	6	0	0.832	1.000	1.000
548	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), NTAN1(10), SIRT1(7), SIRT2(2), SIRT5(2), SIRT7(3), VNN2(4)	6144947	67	55	60	20	21	9	9	11	17	0	0.392	1.000	1.000
549	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(10), NEK1(20), WEE1(15)	3702607	72	55	61	23	11	18	5	19	18	1	0.722	1.000	1.000
550	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	10	APAF1(23), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(3), CASP9(5), CYCS(1), GZMB(4), JUN(2), PRF1(7)	4528240	63	54	53	29	16	14	5	16	12	0	0.939	1.000	1.000
551	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(12), CD38(4), ENPP1(17), ENPP3(10), NADSYN1(4), NMNAT1(2), NMNAT2(4), NNMT(4), NNT(5), NT5C(1), NT5E(6), NT5M(3), QPRT(2)	7785195	74	54	68	23	21	18	9	17	8	1	0.146	1.000	1.000
552	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(10), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(2), CDK5R1(5), CSNK1A1(3), CSNK1D(14), GSK3B(16), MAPT(10), PPP2CA(3)	4347482	73	54	70	23	25	17	5	16	10	0	0.357	1.000	1.000
553	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(1), FLT3(27), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(6), TGFB3(2)	4375309	68	53	62	34	18	17	4	18	10	1	0.964	1.000	1.000
554	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(6), IL10(1), IL10RA(3), IL10RB(6), IL1A(1), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(8), TNF(1)	6253500	79	53	70	31	25	14	6	19	15	0	0.755	1.000	1.000
555	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(13), ADSS(5), DHFR(1), HPRT1(2), IMPDH1(3), MTHFD2(2), POLB(4), POLD1(18), POLG(8), PRPS2(6), RRM1(2), SRM(1)	6276418	65	53	63	26	24	6	10	12	13	0	0.729	1.000	1.000
556	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(4), FOSL1(1), FOSL2(4), IFNAR1(7), IFNAR2(3), IFNB1(6), MAPK8(11), NFKB1(8), RELA(9), TNFRSF11A(5), TNFSF11(8), TRAF6(4)	5597305	70	53	68	24	19	15	9	12	15	0	0.410	1.000	1.000
557	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(16), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(2), CDK2(5), CDK4(3), CDKN1B(4), CDKN2A(7), E2F2(7), E2F4(2), PRB1(3)	4415905	61	53	57	23	13	12	9	18	9	0	0.595	1.000	1.000
558	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(16), CKM(6), FBL(6), GPT(6), LDHA(10), LDHB(5), LDHC(4), MAPK14(7), NCL(10)	4545633	70	53	63	27	17	16	10	20	7	0	0.634	1.000	1.000
559	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(10), GNB1(3), HTR2C(13), PLCB1(22), TUB(13)	3723592	65	53	64	26	26	12	7	15	5	0	0.654	1.000	1.000
560	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2)	7032103	68	51	70	32	14	16	7	20	11	0	0.966	1.000	1.000
561	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CSK(3), GRB2(9), PRKCA(5), PTPRA(5), SRC(3)	4794667	60	51	56	23	14	19	5	17	5	0	0.602	1.000	1.000
562	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(6), UBE2A(4), UBE3A(19)	6949809	72	50	69	29	18	16	10	16	12	0	0.740	1.000	1.000
563	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(10), AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3)	4242999	62	49	57	25	29	11	6	9	7	0	0.653	1.000	1.000
564	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	7	CD3D(4), CD3E(2), GZMB(4), ICAM1(4), ITGAL(18), ITGB2(16), PRF1(7)	3616766	55	49	52	24	26	8	3	6	12	0	0.763	1.000	1.000
565	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(10), AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3)	4242999	62	49	57	25	29	11	6	9	7	0	0.653	1.000	1.000
566	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10)	4818345	67	48	66	22	19	9	7	22	10	0	0.494	1.000	1.000
567	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(6), FARSB(11), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4), YARS2(6)	4613164	69	48	63	21	18	8	10	22	11	0	0.393	1.000	1.000
568	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), IMPA2(3), ISYNA1(6), PGM1(8), PGM3(5)	5688831	65	48	62	31	23	11	7	16	8	0	0.858	1.000	1.000
569	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(5), B3GALT5(3), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST8SIA1(10)	5160355	71	48	69	23	23	8	8	22	10	0	0.435	1.000	1.000
570	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	12	CYSLTR1(9), GPR109B(5), GPR161(10), GPR171(10), GPR18(3), GPR34(10), GPR39(3), GPR45(11), GPR65(1), GPR68(5), GPR75(9)	4747692	76	47	67	35	20	14	6	20	15	1	0.959	1.000	1.000
571	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	3915509	58	47	53	17	23	13	3	11	8	0	0.429	1.000	1.000
572	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(10), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RELA(9)	4316122	55	47	52	21	15	12	7	13	8	0	0.662	1.000	1.000
573	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(12), CD44(5), CSF1(4), FCGR3A(4), IL1B(4), IL6R(7), SELL(5), SPN(4), TGFB1(2), TGFB2(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(7), TNFSF8(4)	6662233	70	47	69	21	22	8	12	16	12	0	0.211	1.000	1.000
574	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(7), CAMK1G(5), HDAC9(18), MEF2A(5), MEF2C(15), MEF2D(3), YWHAH(3)	3739887	56	46	61	29	21	8	2	17	7	1	0.964	1.000	1.000
575	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(16), CHKA(4), PCYT1A(4), PDHA1(7), PDHA2(14), PEMT(2), SLC18A3(11)	3473981	61	45	60	36	26	9	10	11	5	0	0.942	1.000	1.000
576	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(5), B3GALT1(3), B3GALT2(10), B3GALT5(3), B3GNT5(3), FUT1(8), FUT2(6), FUT3(4), ST3GAL3(12), ST3GAL4(4)	3540206	58	45	55	22	26	6	3	14	9	0	0.706	1.000	1.000
577	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(25), GNA12(6), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4)	5350557	54	44	52	15	13	8	7	15	11	0	0.354	1.000	1.000
578	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13)	6380793	63	44	61	19	22	12	7	12	10	0	0.430	1.000	1.000
579	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), HMGCS1(1), IDI1(4), LSS(4), MVD(3), MVK(16), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1)	6601604	64	43	54	20	18	7	7	15	17	0	0.617	1.000	1.000
580	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(2), ENO3(5), FARS2(5), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4)	4455212	56	42	51	24	13	7	12	17	7	0	0.840	1.000	1.000
581	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ENO1(3), GPI(5), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(11), TPI1(3)	3979895	49	41	46	23	19	7	4	13	6	0	0.874	1.000	1.000
582	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), PGM1(8), PGM3(5)	5185687	56	41	53	27	19	10	6	15	6	0	0.879	1.000	1.000
583	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(9), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3)	5306104	55	41	55	23	17	11	9	10	8	0	0.786	1.000	1.000
584	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12), XYLT2(15)	3013566	44	40	33	22	15	7	2	6	13	1	0.985	1.000	1.000
585	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12), XYLT2(15)	3013566	44	40	33	22	15	7	2	6	13	1	0.985	1.000	1.000
586	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NFS1(5), PHPT1(2), THTPA(2), TPK1(5)	3347996	47	40	43	14	14	12	5	8	8	0	0.393	1.000	1.000
587	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(12), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(5), APOBEC3F(1), APOBEC3G(6), APOBEC4(7)	3914814	48	38	47	15	19	4	9	8	8	0	0.365	1.000	1.000
588	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	11	CD2(7), CD34(7), CD3D(4), CD3E(2), CD4(4), CD8A(1), CSF3(2), IL3(6), IL6(5), IL8(5), KITLG(3)	2910538	46	38	40	21	8	13	5	12	8	0	0.776	1.000	1.000
589	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(9), MBTPS1(11), MBTPS2(2), SCAP(6), SREBF1(8), SREBF2(9)	5502059	46	38	45	25	13	10	8	8	7	0	0.884	1.000	1.000
590	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(3), FOS(4), FYN(15), JUN(2), MAPK14(7), THBS1(12)	3778936	46	37	42	17	12	7	6	8	13	0	0.533	1.000	1.000
591	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(12), AOC3(9), CES1(13), ESD(4)	2998414	42	36	41	17	15	6	6	10	5	0	0.624	1.000	1.000
592	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	BPNT1(9), CHST11(4), CHST12(4), PAPSS1(4), PAPSS2(5), SULT1A1(4), SULT1A2(4), SULT1E1(5), SULT2A1(4), SULT2B1(4), SUOX(5)	4883015	52	36	49	18	17	8	5	14	8	0	0.565	1.000	1.000
593	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(3), FOS(4), JUN(2), KEAP1(5), MAPK1(3), MAPK14(7), MAPK8(11), NFE2L2(4), PRKCA(5)	4239099	44	35	44	21	8	9	4	16	7	0	0.925	1.000	1.000
594	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(9), NR1H3(16), NR1H4(7), RXRA(8)	2597155	42	34	35	20	11	8	6	6	11	0	0.939	1.000	1.000
595	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(8), F13B(10), HSD17B1(2), HSD17B2(6), HSD17B3(4), HSD17B4(9), HSD3B1(5), HSD3B2(3)	4242355	47	34	45	19	16	10	7	9	5	0	0.524	1.000	1.000
596	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(5), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), ST3GAL3(12)	2030097	39	32	37	18	21	5	2	8	3	0	0.756	1.000	1.000
597	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(6), PLCG1(17), PRKCA(5), PTK2B(13)	3447846	41	32	39	23	11	11	5	8	6	0	0.974	1.000	1.000
598	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(10), CYP2E1(9), NR1I3(3), PTGS1(9), PTGS2(9)	2793524	40	31	40	15	18	4	8	7	3	0	0.605	1.000	1.000
599	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(8), CYP11A1(5), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3)	3506464	39	31	38	23	17	6	6	5	5	0	0.913	1.000	1.000
600	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(11), ALAS2(10), CPOX(3), FECH(3), HMBS(4), PPOX(5), UROD(2), UROS(5)	4051107	43	31	39	11	17	7	5	8	6	0	0.360	1.000	1.000
601	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(6), GOT2(2), TAT(14), TYR(9)	2521444	36	31	30	18	10	5	9	10	2	0	0.865	1.000	1.000
602	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(8), GAD1(15), HDC(8), PNMT(3), TPH1(2)	2671897	36	30	34	17	11	6	2	13	4	0	0.862	1.000	1.000
603	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMB8(6), PSMB9(4)	4401070	37	30	36	19	9	5	5	10	8	0	0.929	1.000	1.000
604	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(9), ACADS(3), ACAT1(7), ECHS1(3), HADHA(10)	2793555	36	29	36	15	9	6	5	7	9	0	0.713	1.000	1.000
605	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), DHFR(1), FPGS(4), GGH(1), SPR(7)	2772845	35	29	34	14	11	7	5	8	4	0	0.598	1.000	1.000
606	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(7), ACAT2(8), BDH1(3), BDH2(2), HMGCS1(1), HMGCS2(5), OXCT1(3), OXCT2(3)	3844184	32	29	30	11	10	6	3	6	7	0	0.590	1.000	1.000
607	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(7), CSF1(4), IL6(5), LDLR(9), LPL(12)	2735901	37	29	35	18	10	11	3	7	6	0	0.796	1.000	1.000
608	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(12), NR3C1(8), PPARG(4), RETN(2), RXRA(8), TNF(1)	2821698	37	29	35	23	10	5	8	8	6	0	0.972	1.000	1.000
609	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(9), PRKCA(5), TGM2(15)	2559717	34	27	33	19	13	6	3	9	3	0	0.904	1.000	1.000
610	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(7), ARG1(2), GLS(2), GLUD1(4), OAT(3), PRODH(5)	2793487	23	22	22	10	10	6	2	1	4	0	0.668	1.000	1.000
611	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(9), HLA-DRB1(6), IL3(6)	1199864	22	21	18	10	4	8	0	7	1	2	0.922	1.000	1.000
612	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(4), CD4(4), CD80(4), HLA-DRB1(6), IL10(1), IL2(4), IL4(5)	1778678	28	20	27	11	7	3	4	8	4	2	0.770	1.000	1.000
613	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(2), TAT(14)	1417414	22	20	17	11	7	1	7	5	2	0	0.839	1.000	1.000
614	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(9), SNAP25(1), STX1A(3), VAMP2(1)	1689745	18	18	16	10	7	4	3	3	1	0	0.943	1.000	1.000
615	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(6), IFNG(3), IL12A(1), IL12B(1), IL18(3), IL2(4)	1606799	18	14	17	14	1	4	5	6	2	0	0.989	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	273768	1	1	1	2	1	0	0	0	0	0	0.955	1.000	1.000
