rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(8), LIPT1(11)	821172	19	17	14	0	0	3	2	3	11	0	0.0552	0.146	1.000
2	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	384581	7	8	7	1	6	0	0	1	0	0	0.331	0.369	1.000
3	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5), TPI1(3)	802771	8	8	8	1	0	0	1	7	0	0	0.397	0.709	1.000
4	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(7), DCN(7), FMOD(8), KERA(7), LUM(12)	1873748	41	36	40	9	10	12	1	14	4	0	0.212	0.817	1.000
5	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	6	ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4)	3071928	58	44	52	9	19	9	7	15	8	0	0.0105	0.856	1.000
6	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	6	ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4)	3071928	58	44	52	9	19	9	7	15	8	0	0.0105	0.856	1.000
7	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(4), CD4(4), HLA-DRB1(6)	912125	14	12	13	7	1	0	2	5	4	2	0.963	0.860	1.000
8	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	5	BAAT(3), CDO1(3), CSAD(4), GAD1(15), GAD2(15)	2490512	40	36	33	8	16	6	4	11	3	0	0.0702	0.936	1.000
9	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(3), CASP8(19), CFL1(2), CFLAR(2), PDE6D(2)	1974946	30	28	28	5	5	2	3	8	12	0	0.194	0.952	1.000
10	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), IL8(5), SLPI(2)	832960	16	15	15	7	2	3	2	3	6	0	0.794	0.958	1.000
11	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPX1(4), PRKCE(4)	3921206	100	77	93	24	25	15	11	33	16	0	0.0327	0.961	1.000
12	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	4	ALDH6A1(5), ALDOA(2), ALDOC(1), TPI1(3)	1518887	11	11	11	1	2	0	1	8	0	0	0.198	0.962	1.000
13	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	10	ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), SDS(3)	5250902	87	63	80	14	27	12	13	21	14	0	0.00171	0.963	1.000
14	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(5), B3GNT1(5), FUT1(8), FUT2(6), FUT9(9), GCNT2(24), ST8SIA1(10)	2877199	67	53	62	17	20	8	8	22	8	1	0.0941	0.976	1.000
15	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(7), ACAT2(8), ACYP1(1), ECHS1(3), EHHADH(13), GCDH(6), HADHA(10), SDHB(3), SDS(3)	4069262	54	43	51	9	14	8	9	12	11	0	0.0190	0.976	1.000
16	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	2	BMP1(17), BMPR1B(14)	1523595	31	26	30	7	11	4	2	7	7	0	0.337	0.978	1.000
17	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(3), GSTZ1(4), HGD(5)	1190363	12	10	11	3	0	1	5	4	2	0	0.300	0.986	1.000
18	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(12), SPCS1(2), SPCS3(2)	1621531	21	18	19	5	8	3	1	6	3	0	0.213	0.993	1.000
19	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	2	CD3D(4), CD3E(2)	428871	6	6	4	3	0	4	1	0	1	0	0.751	0.993	1.000
20	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	3	ALDH1A1(11), BCMO1(5), RDH5(2)	1472552	18	16	18	6	3	4	2	6	3	0	0.615	0.998	1.000
21	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(3), EHHADH(13), HADHA(10), SDS(3)	2543336	29	26	28	7	8	3	6	6	6	0	0.205	0.999	1.000
22	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	8	ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), MIOX(3), UGDH(8)	3803280	64	49	56	13	19	11	7	13	14	0	0.0818	0.999	1.000
23	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(7), ACAA2(2), ACAT1(7), ACAT2(8), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), SDS(3)	4429277	62	51	59	13	13	12	12	13	12	0	0.0329	0.999	1.000
24	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(5), CBS(3), CTH(5), MUT(7)	2444165	23	19	23	4	9	1	6	3	4	0	0.0855	1.000	1.000
25	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(11), CD28(4), CD3D(4), CD3E(2), CD4(4)	1572475	25	23	22	8	3	4	5	8	5	0	0.541	1.000	1.000
26	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(6), RANBP2(24), RANGAP1(4)	4139507	36	31	34	4	7	6	5	10	8	0	0.0208	1.000	1.000
27	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(11), ACO2(7), FH(9), IDH2(16), MDH1(8), MDH2(3), SDHB(3), SUCLA2(6)	4267223	63	57	57	13	13	12	9	18	11	0	0.0454	1.000	1.000
28	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(6), GRIA2(23), PPP1R1B(1)	1746011	32	28	32	11	13	5	3	8	3	0	0.380	1.000	1.000
29	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(11), CYP2C9(8)	1088534	19	19	18	5	2	7	2	7	1	0	0.431	1.000	1.000
30	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(5), ST6GALNAC4(3), ST8SIA1(10)	2831569	31	28	29	7	10	7	3	5	6	0	0.159	1.000	1.000
31	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(12), AGT(10), AGTR1(12), BDKRB2(4), KNG1(8), NOS3(21), REN(8)	4146324	75	50	68	13	20	6	11	17	21	0	0.0185	1.000	1.000
32	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(1), CSF1(4), CSF3(2), EPO(1), IL11(6), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), IL9(1)	3217023	47	38	44	13	14	11	4	13	4	1	0.219	1.000	1.000
33	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(4), GALT(3), UGDH(8), UGP2(10), UXS1(8)	2598375	33	30	33	7	8	1	6	8	10	0	0.416	1.000	1.000
34	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(9), CD4(4), HLA-DRB1(6), IL1B(4), IL4(5), IL5RA(9), IL6(5)	2510259	43	27	40	13	13	6	5	14	3	2	0.392	1.000	1.000
35	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(12), PDXK(1), PDXP(1), PNPO(2), PSAT1(6)	2535314	22	21	21	6	6	7	3	3	3	0	0.298	1.000	1.000
36	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(12), ACO1(11), ACO2(7), ACSS1(6), ACSS2(9), FH(9), IDH2(16), MDH1(8), MDH2(3), SUCLA2(6)	6547981	87	69	80	16	23	16	12	23	13	0	0.00504	1.000	1.000
37	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	2460399	25	23	22	6	10	4	1	7	3	0	0.289	1.000	1.000
38	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(12), RAB11A(3), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(3), RAB6A(4), RAB9A(2)	2211388	37	30	35	11	12	5	8	5	7	0	0.276	1.000	1.000
39	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(6)	1061048	14	13	14	6	8	1	3	0	2	0	0.643	1.000	1.000
40	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	4	ARNTL(11), CRY2(5), CSNK1E(9), PER1(12)	2731395	37	29	35	7	16	6	1	12	2	0	0.0931	1.000	1.000
41	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(4), GALT(3), UGDH(8), UXS1(8)	2029445	23	22	23	6	6	1	4	5	7	0	0.606	1.000	1.000
42	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(7), ERBB3(28), NRG1(26), UBE2D1(1)	4069263	62	50	51	12	20	15	7	10	10	0	0.0518	1.000	1.000
43	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(4), IL1B(4), MST1(5), MST1R(14), TNF(1)	2643030	28	25	25	7	9	4	4	8	3	0	0.198	1.000	1.000
44	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(9), PAPSS1(4), PAPSS2(5), SULT1A2(4), SULT1E1(5), SULT2A1(4), SUOX(5)	3569533	36	26	33	7	11	5	4	9	7	0	0.172	1.000	1.000
45	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(7)	910750	11	10	11	6	4	1	2	3	1	0	0.851	1.000	1.000
46	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BIRC3(11), CASP8(19), FADD(1), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	3519536	52	43	44	14	10	14	3	9	16	0	0.217	1.000	1.000
47	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(7), ACOX1(11), ACOX3(8), ELOVL2(9), ELOVL5(3), ELOVL6(3), FADS2(10), HADHA(10), HSD17B12(3), SCD(4)	5597538	68	53	65	11	22	8	10	17	11	0	0.00393	1.000	1.000
48	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(7), ACAT2(8), OXCT1(3)	1813873	18	16	16	8	2	5	3	4	4	0	0.827	1.000	1.000
49	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(11), KARS(8)	2561211	22	19	21	5	4	1	5	8	4	0	0.429	1.000	1.000
50	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH2(16), MGST1(2), MGST2(2), MGST3(1), PGD(7)	8296731	130	78	121	26	31	20	22	41	16	0	0.00205	1.000	1.000
51	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	4	ATP6V0C(1), GBA3(3), SHMT1(6), SHMT2(5)	1517134	15	15	18	7	6	1	2	2	4	0	0.830	1.000	1.000
52	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8)	2941977	39	35	36	13	5	13	6	13	2	0	0.359	1.000	1.000
53	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	3	GLS(2), GLS2(6), GLUD1(4)	1771605	12	12	12	4	5	3	0	3	1	0	0.611	1.000	1.000
54	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(13), GBA(4), GBA3(3), LPO(9), MPO(13), PRDX6(4), TPO(29)	4183716	75	58	69	18	37	11	5	11	11	0	0.0736	1.000	1.000
55	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), FDPS(6), IDI1(4), SQLE(1)	1611811	14	14	14	5	1	2	3	4	4	0	0.715	1.000	1.000
56	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNG(3), IFNGR1(6), IFNGR2(4), JAK1(20), STAT1(15)	3152891	48	37	44	13	14	11	0	13	9	1	0.416	1.000	1.000
57	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(5), CDK7(3), MNAT1(3), SHH(3), XPO1(7)	4537450	58	46	56	13	15	11	8	19	5	0	0.0951	1.000	1.000
58	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), FDPS(6), GGPS1(4), IDI1(4), IDI2(3), SQLE(1)	2198213	21	21	20	6	4	2	3	5	7	0	0.562	1.000	1.000
59	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7)	6799094	108	67	101	25	18	22	20	34	13	1	0.0238	1.000	1.000
60	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	4	ACACA(30), ACACB(37), MCAT(3), OXSM(10)	6119185	80	50	78	15	28	11	15	18	8	0	0.0122	1.000	1.000
61	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(12), PARK2(11), SNCA(2), SNCAIP(6), UBE2E2(3), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5)	3325112	45	35	44	13	13	2	9	14	7	0	0.286	1.000	1.000
62	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	IL13(2), IL4(5), MAF(9), MAP2K3(8), MAPK14(7), NFATC2(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	4691769	66	55	66	18	29	11	6	12	8	0	0.0738	1.000	1.000
63	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(11), DLL1(6), FURIN(14), PSEN1(3)	2426914	34	27	34	11	11	5	5	7	6	0	0.336	1.000	1.000
64	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(5), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GCNT2(24), ST3GAL6(12), ST8SIA1(10)	6934431	120	82	112	28	40	18	10	34	17	1	0.0354	1.000	1.000
65	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(2), COQ6(2), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1)	2135214	16	16	18	6	6	1	6	1	2	0	0.570	1.000	1.000
66	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(6), MMP2(12), MMP9(14), RECK(12), TIMP1(1), TIMP2(3), TIMP3(10), TIMP4(4)	3887906	66	50	63	19	33	11	5	11	6	0	0.146	1.000	1.000
67	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), KARS(8)	3769147	42	35	39	11	8	5	6	15	8	0	0.433	1.000	1.000
68	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	14	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4)	6346984	98	71	88	28	26	22	14	25	11	0	0.127	1.000	1.000
69	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	ASRGL1(1), GBA(4), GBA3(3), SHMT1(6), SHMT2(5)	2285759	19	18	22	9	8	1	2	3	5	0	0.868	1.000	1.000
70	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(5), ICAM1(4), ITGAL(18), ITGAM(13), ITGB2(16), SELE(11), SELL(5)	5180842	72	56	73	22	28	12	7	12	13	0	0.248	1.000	1.000
71	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	7	DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9)	3843584	33	27	33	8	11	8	5	3	6	0	0.217	1.000	1.000
72	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(11), ALAS2(10), CPO(9), FECH(3), GATA1(18), HBB(2), HMBS(4), UROD(2), UROS(5)	4302767	64	46	59	16	19	16	7	13	9	0	0.155	1.000	1.000
73	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(10), CARS2(6), CDO1(3), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), SDS(3), SULT1B1(5), SULT1C2(6), SULT1C4(3), SULT4A1(6)	6472072	85	64	78	21	29	16	11	17	12	0	0.0739	1.000	1.000
74	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	7	OXA1L(5), SEC61A2(4), SRP19(1), SRP54(2), SRP68(10), SRP72(8)	3329702	30	25	30	8	8	7	4	9	2	0	0.319	1.000	1.000
75	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	5	IL13(2), IL13RA1(5), IL4R(6), JAK1(20), TYK2(5)	3686443	38	35	35	10	13	11	0	8	6	0	0.325	1.000	1.000
76	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	5	IL13(2), IL13RA1(5), IL4R(6), JAK1(20), TYK2(5)	3686443	38	35	35	10	13	11	0	8	6	0	0.325	1.000	1.000
77	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(7), IFNAR1(7), IFNAR2(3), IFNB1(6), JAK1(20), STAT1(15), STAT2(10), TYK2(5)	5559736	73	56	64	19	21	17	6	18	11	0	0.183	1.000	1.000
78	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(11), PON2(6), PON3(10), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	4334998	68	50	62	20	17	17	7	17	10	0	0.272	1.000	1.000
79	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(11), ACOX3(8), FADS2(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8)	5392445	63	46	60	14	22	11	7	14	9	0	0.0417	1.000	1.000
80	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(10), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHB(5), LDHC(4)	3413585	42	38	37	12	14	10	5	7	6	0	0.336	1.000	1.000
81	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(3), CASP7(3), DFFA(4), DFFB(2), ENDOG(3), GZMB(4), HMGB1(2), HMGB2(2), TOP2A(23), TOP2B(24)	4743669	70	55	59	16	10	13	7	20	20	0	0.427	1.000	1.000
82	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	10	ADCY1(22), ADRB2(3), PLCE1(32), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RAP2B(2)	6390625	84	60	81	25	27	21	6	20	10	0	0.128	1.000	1.000
83	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	9	ARNTL(11), CRY2(5), CSNK1D(14), CSNK1E(9), NPAS2(10), NR1D1(7), PER1(12), PER2(7), PER3(18)	7026321	93	65	85	20	38	21	7	21	6	0	0.00470	1.000	1.000
84	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(6), CAT(7), EPX(13), LPO(9), MPO(13), MTHFR(8), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29)	5802832	100	70	89	26	47	13	10	16	14	0	0.0811	1.000	1.000
85	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(2), CDK2(5), CDK4(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(3)	3516361	52	43	48	16	8	13	8	11	12	0	0.396	1.000	1.000
86	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), RFK(1), TYR(9)	5145819	67	43	60	15	18	18	8	14	8	1	0.0505	1.000	1.000
87	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), RAC1(2), WASF1(3), WASL(16)	4286018	61	44	58	19	17	7	9	18	10	0	0.398	1.000	1.000
88	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(8), GNAQ(10), ITPKA(3), ITPKB(14)	2758937	40	34	39	14	15	7	3	10	5	0	0.502	1.000	1.000
89	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	7	ADAM17(11), AXIN1(8), BTRC(7), DLL1(6), FZD1(7), GSK3B(16), PSEN1(3)	4038298	58	42	56	20	16	13	8	10	10	1	0.353	1.000	1.000
90	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	10	AKT1(11), BAD(1), HRAS(4), IGF1R(17), IRS1(17), MAPK1(3), MAPK3(3), SHC1(13), SOS1(11), YWHAH(3)	6111064	83	65	71	21	25	11	12	14	20	1	0.176	1.000	1.000
91	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(13), EIF2AK4(21), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF5(6), GSK3B(16), PPP1CA(2)	5915668	79	63	68	18	14	28	5	13	19	0	0.0963	1.000	1.000
92	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3)	3758496	51	39	49	13	14	6	5	8	18	0	0.230	1.000	1.000
93	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(11), ACO2(7), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2)	6796112	74	53	68	18	23	9	13	19	10	0	0.0429	1.000	1.000
94	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	C9orf47(2), CNR1(10), CNR2(1), DNMT1(20), MTNR1A(2), MTNR1B(11), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2)	5210537	69	49	62	19	29	9	6	13	12	0	0.0412	1.000	1.000
95	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(8), ANKRD1(7), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(8), IL18(3), IL1A(1), IL1R1(6), MYOG(5), NR4A3(7), WDR1(7)	5529734	59	40	59	15	16	12	8	15	8	0	0.161	1.000	1.000
96	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(13), GBA3(3), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TPO(29), TYR(9)	4802549	86	64	79	23	41	15	7	13	10	0	0.0874	1.000	1.000
97	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(4), GSR(5), GSS(8), IL8(5), NFKB1(8), NOX1(4), RELA(9), TNF(1), XDH(19)	5182619	63	50	59	17	13	20	7	9	14	0	0.236	1.000	1.000
98	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	7	ADORA1(14), ADORA2A(4), ADORA2B(5), LTB4R(1), P2RY1(5), P2RY2(6), P2RY6(5)	2015662	40	31	38	16	18	9	6	4	3	0	0.335	1.000	1.000
99	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(2), CTSD(6), ESR1(20), GREB1(24), HSPB2(2), MTA1(6), MTA3(3), PDZK1(2), TUBA8(4)	4753786	69	48	69	23	26	7	9	13	14	0	0.349	1.000	1.000
100	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(3), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), MECR(4), PPT1(1), PPT2(4)	4419959	46	40	46	14	12	9	5	11	9	0	0.346	1.000	1.000
101	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(22), CREM(10), FHL5(8), FSHB(4), FSHR(16), XPO1(7)	3889125	67	48	59	21	22	20	8	12	5	0	0.258	1.000	1.000
102	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(2), FH(9), IDH2(16), MDH1(8), OGDH(13), SDHA(12), SUCLA2(6)	4929826	73	61	65	23	22	13	8	16	14	0	0.341	1.000	1.000
103	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), CYCS(1), GPD2(10), NDUFA1(2), SDHA(12), SDHB(3), SDHD(4), UQCRC1(4)	3380932	40	30	40	11	17	2	8	10	3	0	0.304	1.000	1.000
104	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(8), ME1(11), PC(12), PDHA1(7), SLC25A1(1), SLC25A11(2)	4576581	55	49	49	16	17	15	7	9	7	0	0.219	1.000	1.000
105	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	21	ABP1(4), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), AOC2(12), AOC3(9), ASPA(6), CNDP1(7), DDC(5), HAL(11), HARS(6), HDC(8), HNMT(11), MAOA(5), MAOB(6), PRPS2(6)	11289946	169	106	154	38	53	29	21	44	22	0	0.00439	1.000	1.000
106	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	CISH(2), IFNG(3), IFNGR1(6), JAK1(20), PTPRU(18), REG1A(6), STAT1(15)	4727773	70	49	65	18	25	14	4	13	13	1	0.221	1.000	1.000
107	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(31), GLS(2), GLUD1(4), GOT1(6)	4073816	48	37	44	13	11	13	10	10	4	0	0.199	1.000	1.000
108	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(6), ATP6V0C(1), CAT(7), EPX(13), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29)	5869137	99	70	88	27	49	13	10	13	14	0	0.0757	1.000	1.000
109	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(4), UBE2A(4), UBE2B(3), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(3), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(19)	5278573	63	44	61	20	17	11	5	13	17	0	0.384	1.000	1.000
110	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(23), BAD(1), BAK1(2), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), CASP8AP2(27), CASP9(5), CES1(13)	5188402	87	56	79	26	20	8	14	20	24	1	0.621	1.000	1.000
111	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(11), ACO2(7), AFMID(2), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2)	7126627	76	53	70	20	23	9	13	21	10	0	0.0708	1.000	1.000
112	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	174	ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), BAD(1), BCAR1(5), BCL2(2), BIRC2(5), BIRC3(11), CAPN2(8), CAV2(4), CAV3(3), CCND1(2), CCND2(3), CCND3(2), CDC42(2), CHAD(9), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), CRKL(5), DIAPH1(7), DOCK1(22), EGF(7), ELK1(4), ERBB2(28), FARP2(12), FIGF(4), FLNA(24), FLNB(36), FLNC(36), FLT1(34), FN1(52), FYN(15), GRLF1(18), GSK3B(16), HGF(13), HRAS(4), IBSP(6), IGF1(6), IGF1R(17), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), JUN(2), KDR(38), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(1), PDGFD(11), PDGFRA(56), PDGFRB(20), PDPK1(4), PGF(3), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PRKCA(5), PRKCG(19), PTEN(286), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF1(19), RELN(83), ROCK1(27), ROCK2(15), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SPP1(4), SRC(3), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TLN1(21), TLN2(13), TNC(38), TNN(30), TNR(45), TNXB(51), VASP(4), VAV1(22), VAV3(27), VCL(9), VEGFA(5), VEGFC(11), VTN(10), VWF(30), ZYX(2)	167888761	2823	334	2566	1135	798	615	362	619	410	19	0.936	1.000	1.000
113	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	213	ADCYAP1R1(4), ADORA1(14), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA2A(5), ADRA2B(6), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), C5AR1(7), CALCR(8), CALCRL(7), CCKAR(6), CCKBR(12), CGA(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CNR1(10), CNR2(1), CRHR1(4), CRHR2(5), CTSG(4), CYSLTR1(9), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2(9), F2R(11), F2RL2(6), FPR1(5), FSHB(4), FSHR(16), GABBR1(16), GABBR2(15), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GABRB1(10), GABRB2(7), GABRB3(14), GABRD(6), GABRE(10), GABRG1(17), GABRG2(15), GABRG3(11), GABRP(9), GABRQ(16), GABRR1(5), GABRR2(8), GALR1(4), GH1(4), GH2(4), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(6), GLP2R(8), GLRA1(10), GLRA2(8), GLRA3(12), GLRB(13), GNRHR(9), GPR156(15), GPR35(3), GPR50(9), GPR63(4), GPR83(6), GRIA1(35), GRIA2(23), GRIA3(11), GRIA4(36), GRID1(28), GRID2(25), GRIK1(13), GRIK2(43), GRIK3(28), GRIK4(20), GRIK5(14), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRIN3A(16), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM6(24), GRM7(30), GRM8(27), GRPR(4), GZMA(8), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HRH4(6), HTR1A(15), HTR1B(11), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LEP(1), LEPR(15), LHB(3), LTB4R(1), MAS1(2), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), MCHR1(8), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPBWR1(5), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(6), NPY2R(12), NPY5R(5), NR3C1(8), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), P2RY1(5), P2RY10(12), P2RY14(9), P2RY2(6), P2RY4(8), P2RY6(5), PARD3(11), PPYR1(5), PRL(3), PRLHR(5), PRLR(8), PRSS1(6), PRSS3(6), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTH2R(14), RXFP1(6), RXFP2(18), SCTR(5), SSTR1(11), SSTR2(4), SSTR4(12), TAAR1(6), TAAR2(6), TAAR5(8), TAAR6(4), TAAR8(5), TAAR9(6), TACR1(9), TACR2(4), TACR3(11), THRA(6), THRB(14), TRHR(7), TRPV1(9), TSHB(1), TSPO(1), VIPR1(6), VIPR2(11)	102375063	1996	319	1847	758	703	344	229	467	250	3	0.314	1.000	1.000
114	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	160	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY7(10), ADCY8(30), ADCY9(19), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), ATP2A1(23), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), ATP2B4(21), AVPR1A(13), AVPR1B(5), BDKRB1(3), BDKRB2(4), BST1(2), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CCKAR(6), CCKBR(12), CD38(4), CHRM1(4), CHRM2(25), CHRM3(21), CHRM5(5), CYSLTR1(9), DRD1(9), EDNRA(8), EDNRB(13), ERBB2(28), ERBB3(28), ERBB4(56), F2R(11), GNA11(8), GNA14(10), GNA15(5), GNAL(4), GNAQ(10), GRIN1(5), GRIN2A(48), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), GRPR(4), HRH1(4), HRH2(15), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), MYLK(29), MYLK2(9), NOS1(23), NOS3(21), NTSR1(5), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), PDE1A(8), PDE1B(10), PDE1C(17), PDGFRA(56), PDGFRB(20), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PPID(4), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTAFR(1), PTGFR(7), PTK2B(13), RYR1(58), RYR2(122), RYR3(82), SLC25A4(4), SLC25A5(8), SLC8A1(22), SLC8A2(14), SLC8A3(13), SPHK1(2), SPHK2(5), TACR1(9), TACR2(4), TACR3(11), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(15), VDAC1(6), VDAC2(4), VDAC3(2)	127915195	2227	317	2117	837	792	394	247	471	313	10	0.547	1.000	1.000
115	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	132	ACTB(4), ACTG1(6), CHAD(9), COL11A2(17), COL17A1(13), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), DES(5), DSC1(12), DSC2(16), DSC3(12), DSG1(19), DSG2(11), DSG3(17), DSG4(24), FN1(52), GJA1(5), GJA10(12), GJA3(4), GJA4(3), GJA5(7), GJA8(19), GJA9(5), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GJB7(3), GJC1(9), GJC3(3), GJD2(4), GJD4(4), IBSP(6), INA(8), ITGA6(14), ITGB4(16), KRT1(18), KRT10(7), KRT12(6), KRT13(11), KRT14(8), KRT15(8), KRT16(5), KRT17(10), KRT18(3), KRT19(4), KRT2(14), KRT20(2), KRT23(9), KRT24(2), KRT25(12), KRT27(2), KRT28(5), KRT3(10), KRT31(12), KRT32(6), KRT33A(8), KRT33B(5), KRT34(11), KRT35(5), KRT36(5), KRT37(8), KRT38(1), KRT39(9), KRT40(2), KRT5(7), KRT6A(7), KRT6B(6), KRT6C(6), KRT7(4), KRT71(9), KRT72(14), KRT73(10), KRT74(7), KRT75(13), KRT76(9), KRT77(6), KRT78(5), KRT79(7), KRT8(4), KRT81(2), KRT82(5), KRT83(3), KRT84(8), KRT85(12), KRT86(4), KRT9(12), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), LMNB1(9), LMNB2(2), NES(28), PRPH(2), RELN(83), SPP1(4), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VIM(7), VTN(10), VWF(30)	118376819	1866	313	1757	728	660	285	264	398	257	2	0.661	1.000	1.000
116	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	81	CD36(3), CD44(5), CD47(8), CHAD(9), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), DAG1(8), FN1(52), FNDC1(37), FNDC3A(13), FNDC4(6), FNDC5(2), GP5(8), GP6(11), GP9(1), HMMR(15), HSPG2(26), IBSP(6), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), RELN(83), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SPP1(4), SV2A(22), SV2B(9), SV2C(13), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VTN(10), VWF(30)	105475958	1610	299	1530	657	553	239	223	357	235	3	0.871	1.000	1.000
117	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	226	ACVR1C(9), AKT1(11), AKT2(7), AKT3(7), ARRB1(4), ARRB2(1), ATF2(6), ATF4(2), BDNF(4), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CACNA2D1(28), CACNA2D2(9), CACNA2D3(21), CACNA2D4(12), CACNB1(6), CACNB2(9), CACNB3(2), CACNB4(3), CACNG1(5), CACNG2(5), CACNG3(8), CACNG4(4), CACNG5(8), CACNG6(3), CACNG7(6), CACNG8(2), CASP3(3), CD14(6), CDC25B(11), CDC42(2), CRKL(5), DAXX(14), DDIT3(4), DUSP1(6), DUSP10(5), DUSP16(9), DUSP3(4), DUSP4(6), DUSP5(1), DUSP6(6), DUSP7(6), DUSP9(9), ECSIT(6), EGF(7), ELK1(4), FAS(7), FASLG(3), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF3(5), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR4(11), FLNA(24), FLNB(36), FLNC(36), FOS(4), GADD45G(1), GNA12(6), HRAS(4), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), JUN(2), MAP2K2(2), MAP2K3(8), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAPT(10), MAX(5), MEF2C(15), MKNK1(2), MKNK2(6), MOS(8), MRAS(4), MYC(5), NFATC2(10), NFATC4(11), NFKB1(8), NFKB2(4), NLK(12), NR4A1(3), NTF3(3), NTRK1(16), NTRK2(23), PAK1(10), PAK2(14), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PPM1A(8), PPM1B(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PPP5C(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTPN5(7), PTPN7(3), PTPRR(11), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF2(29), RASA1(20), RASA2(15), RASGRF1(22), RASGRF2(20), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KA6(15), RRAS(2), RRAS2(4), SOS1(11), SOS2(15), SRF(4), STK3(8), STK4(8), STMN1(1), TAOK1(17), TAOK2(13), TAOK3(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF1A(4), TRAF2(8), TRAF6(4), ZAK(8)	130053210	2017	292	1883	694	641	370	248	425	326	7	0.0710	1.000	1.000
118	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	183	ABI2(3), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ARAF(10), ARHGEF1(13), ARHGEF12(10), ARHGEF4(8), ARHGEF6(16), ARHGEF7(21), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(2), BAIAP2(6), BCAR1(5), BDKRB1(3), BDKRB2(4), CD14(6), CDC42(2), CFL1(2), CFL2(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CRKL(5), CSK(3), CYFIP1(15), CYFIP2(10), DIAPH1(7), DIAPH2(24), DIAPH3(17), DOCK1(22), EGF(7), EZR(3), F2(9), F2R(11), FGD1(18), FGD3(15), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF3(5), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR4(11), FN1(52), GIT1(3), GNA12(6), GNA13(3), GRLF1(18), GSN(4), HRAS(4), IQGAP1(24), IQGAP2(25), IQGAP3(23), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LIMK1(7), LIMK2(11), MAP2K2(2), MAPK1(3), MAPK3(3), MOS(8), MRAS(4), MSN(6), MYH10(15), MYH14(22), MYH9(40), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), NCKAP1(15), NCKAP1L(21), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PFN2(4), PFN4(6), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PTK2(24), PXN(2), RAC1(2), RAC2(1), RDX(13), ROCK1(27), ROCK2(15), RRAS(2), RRAS2(4), SCIN(10), SLC9A1(9), SOS1(11), SOS2(15), SSH1(13), SSH2(16), SSH3(3), TIAM1(34), TIAM2(24), TMSL3(2), VAV1(22), VAV3(27), VCL(9), WAS(4), WASF1(3), WASF2(5), WASL(16)	127021377	1849	292	1724	677	541	347	226	430	295	10	0.689	1.000	1.000
119	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(18), ATP1B1(4), ATP1B2(2), ATP1B3(4), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1S(29), CACNB1(6), CACNB3(2), CALM2(1), CALM3(1), CALR(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CASQ1(4), CASQ2(8), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), GJA1(5), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), ITPR1(41), ITPR2(41), ITPR3(39), KCNB1(19), KCNJ3(11), KCNJ5(10), MIB1(8), NME7(6), PEA15(1), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SLC8A3(13), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1)	92811437	1513	284	1458	564	559	244	172	308	222	8	0.365	1.000	1.000
120	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	123	ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), AMOTL1(15), ASH1L(51), CASK(9), CDC42(2), CDK4(3), CGN(15), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTTN(4), EPB41(11), EPB41L1(13), EPB41L2(12), EPB41L3(31), EXOC3(3), EXOC4(19), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), HCLS1(15), HRAS(4), IGSF5(14), INADL(15), JAM2(2), JAM3(9), LLGL1(6), LLGL2(6), MAGI1(27), MAGI2(25), MAGI3(8), MLLT4(17), MPDZ(23), MPP5(6), MRAS(4), MYH1(38), MYH10(15), MYH11(40), MYH13(26), MYH14(22), MYH15(31), MYH2(37), MYH3(39), MYH4(28), MYH6(27), MYH7(24), MYH7B(27), MYH8(42), MYH9(40), MYL2(2), MYL7(1), OCLN(2), PARD3(11), PARD6A(1), PARD6B(2), PARD6G(6), PPM1J(3), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP2R3A(14), PPP2R4(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PTEN(286), RAB13(1), RAB3B(3), RRAS(2), RRAS2(4), SPTAN1(25), SRC(3), SYMPK(11), TJAP1(3), TJP1(21), TJP2(17), TJP3(11), VAPA(2), YES1(9), ZAK(8)	95657856	1647	280	1437	569	484	394	202	321	229	17	0.163	1.000	1.000
121	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(12), ACTA2(3), ACTN2(15), ACTN3(6), ACTN4(7), DES(5), DMD(72), FAM48A(9), MYBPC1(9), MYBPC2(16), MYBPC3(14), MYH3(39), MYH6(27), MYH7(24), MYH8(42), MYL2(2), MYL3(1), MYL4(3), NEB(98), TMOD1(7), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(2), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(7), TPM3(6), TPM4(8), TTN(727), VIM(7)	61299408	1189	280	1087	359	338	251	147	336	99	18	0.00156	1.000	1.000
122	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(12), ACTA2(3), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADM(5), ARRB1(4), ARRB2(1), ATF1(5), ATF2(6), ATF3(1), ATF4(2), ATF5(2), ATP2A2(16), ATP2A3(11), CACNB3(2), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CNN1(4), CNN2(3), CORIN(18), CREB3(5), CRHR1(4), DGKZ(8), ETS2(4), FOS(4), GABPA(13), GABPB2(3), GBA2(15), GJA1(5), GNAQ(10), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), GSTO1(1), GUCA2B(3), GUCY1A3(25), IGFBP1(2), IGFBP2(3), IGFBP4(4), IGFBP6(2), IL1B(4), IL6(5), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), MIB1(8), MYL2(2), MYL4(3), MYLK2(9), NFKB1(8), NOS1(23), NOS3(21), OXTR(2), PDE4B(9), PDE4D(7), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PLCD1(9), PLCG1(17), PLCG2(23), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RAMP1(2), RAMP2(2), RAMP3(6), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RLN1(3), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SP1(6), TNXB(51), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1)	83191834	1352	274	1304	473	470	214	170	288	204	6	0.103	1.000	1.000
123	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	226	ACVR1(6), ACVR2B(12), AMHR2(4), BMP2(8), BMP7(14), BMPR1B(14), CCL11(1), CCL13(1), CCL15(2), CCL16(2), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL4(1), CCL7(2), CCL8(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CD27(4), CD40(6), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(4), CSF1R(15), CSF2RB(13), CSF3(2), CSF3R(18), CX3CL1(4), CX3CR1(5), CXCL1(1), CXCL10(1), CXCL11(3), CXCL12(2), CXCL14(1), CXCL16(2), CXCL5(5), CXCL6(1), CXCL9(6), CXCR3(4), CXCR4(6), CXCR6(1), EDA(2), EDA2R(4), EDAR(6), EGF(7), EPO(1), EPOR(2), FAS(7), FASLG(3), FLT1(34), FLT3(27), FLT3LG(1), FLT4(16), GDF5(11), GH1(4), GH2(4), GHR(12), HGF(13), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL15(1), IL15RA(1), IL17A(2), IL17B(1), IL17RA(7), IL17RB(8), IL18(3), IL18R1(13), IL18RAP(10), IL19(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL1RAP(5), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL25(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL8(5), IL9(1), INHBA(17), INHBB(3), INHBC(3), INHBE(2), KDR(38), KITLG(3), LEP(1), LEPR(15), LIF(1), LIFR(35), LTA(1), LTBR(4), MPL(5), NGFR(4), OSM(4), OSMR(20), PDGFB(1), PDGFRA(56), PDGFRB(20), PF4(3), PLEKHO2(7), PPBP(6), PRL(3), PRLR(8), RELT(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(5), TNFRSF11B(5), TNFRSF13B(6), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFRSF8(7), TNFSF10(2), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(3), TNFSF14(3), TNFSF15(3), TNFSF4(4), TNFSF8(4), TPO(29), TSLP(3), VEGFA(5), VEGFC(11), XCL1(1), XCL2(3), XCR1(5)	80887525	1242	270	1145	434	349	229	154	322	183	5	0.173	1.000	1.000
124	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	119	ABL1(27), ABLIM1(8), ABLIM2(7), ABLIM3(15), ARHGEF12(10), CDC42(2), CDK5(2), CFL1(2), CFL2(2), CXCL12(2), CXCR4(6), DCC(36), DPYSL2(9), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(3), EFNB1(6), EFNB3(9), EPHA1(7), EPHA2(12), EPHA3(61), EPHA4(20), EPHA5(39), EPHA6(25), EPHA7(38), EPHA8(16), EPHB1(33), EPHB2(15), EPHB3(12), EPHB4(11), EPHB6(12), FES(6), FYN(15), GNAI1(3), GNAI2(2), GNAI3(2), GSK3B(16), HRAS(4), ITGB1(12), L1CAM(14), LIMK1(7), LIMK2(11), LRRC4C(14), MAPK1(3), MAPK3(3), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NGEF(17), NRP1(11), NTN1(4), NTN4(7), NTNG1(14), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLXNA1(20), PLXNA2(21), PLXNA3(22), PLXNB1(20), PLXNB2(26), PLXNB3(22), PLXNC1(18), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RASA1(20), RGS3(22), RND1(3), ROBO1(30), ROBO3(10), ROCK1(27), ROCK2(15), SEMA3A(17), SEMA3B(7), SEMA3C(17), SEMA3D(22), SEMA3E(17), SEMA3F(12), SEMA3G(8), SEMA4A(12), SEMA4B(3), SEMA4C(5), SEMA4D(17), SEMA4F(9), SEMA4G(9), SEMA5A(19), SEMA5B(22), SEMA6A(8), SEMA6B(6), SEMA6C(11), SEMA6D(11), SEMA7A(2), SLIT1(28), SLIT2(29), SLIT3(23), SRGAP1(23), SRGAP2(9), SRGAP3(19), UNC5A(6), UNC5B(8), UNC5C(13), UNC5D(21)	89659694	1483	268	1375	559	487	269	168	314	237	8	0.777	1.000	1.000
125	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	115	ALCAM(11), CADM1(15), CADM3(13), CD2(7), CD22(15), CD226(4), CD274(4), CD276(6), CD28(4), CD34(7), CD4(4), CD40(6), CD40LG(10), CD6(5), CD80(4), CD86(2), CD8A(1), CD8B(4), CDH15(2), CDH2(33), CDH3(7), CDH4(19), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CNTN1(26), CNTN2(12), CNTNAP1(14), CNTNAP2(33), CTLA4(4), ESAM(6), F11R(4), GLG1(13), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA2(4), HLA-DQB1(1), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), ICAM1(4), ICAM2(5), ICAM3(3), ICOS(2), ICOSLG(4), ITGA4(14), ITGA6(14), ITGA8(16), ITGA9(9), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), ITGB7(7), ITGB8(9), JAM2(2), JAM3(9), L1CAM(14), MAG(9), MPZ(2), MPZL1(7), NCAM1(16), NCAM2(21), NEGR1(4), NEO1(12), NFASC(37), NLGN1(18), NLGN2(4), NLGN3(10), NRCAM(17), NRXN1(41), NRXN2(21), NRXN3(33), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(27), PTPRF(21), PTPRM(38), PVR(1), PVRL1(7), PVRL2(4), PVRL3(4), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SELE(11), SELL(5), SELP(13), SIGLEC1(17), SPN(4), VCAM1(12), VCAN(60)	68250841	1076	261	1022	435	332	161	133	274	173	3	0.895	1.000	1.000
126	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	102	ABL1(27), ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), ATM(200), ATR(43), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDC14A(10), CDC14B(5), CDC16(5), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(5), CDC26(1), CDC27(16), CDC6(6), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CHEK1(10), CREBBP(68), CUL1(16), DBF4(8), E2F2(7), E2F3(5), EP300(42), ESPL1(22), FZR1(3), GADD45G(1), GSK3B(16), HDAC1(5), HDAC2(8), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTTG1(2), RB1(123), RBL1(18), RBL2(22), SFN(1), SKP1(2), SKP2(3), SMAD3(17), SMC1A(21), SMC1B(25), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	66999696	1171	259	1007	396	244	319	117	260	212	19	0.352	1.000	1.000
127	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	69	CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS2(9), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5D(8), INPP5E(3), INPPL1(14), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), OCRL(16), PI4KA(24), PI4KB(5), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3C3(25), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PRKCA(5), PRKCG(19), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14)	59485298	1088	258	933	397	269	309	130	225	146	9	0.634	1.000	1.000
128	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	71	ABL1(27), ACTN1(9), ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGEF6(16), ARHGEF7(21), BCAR1(5), CDC42(2), CDKN2A(7), CSE1L(10), DOCK1(22), EPHB2(15), FYN(15), GRB7(3), GRLF1(18), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB3BP(1), MAP3K11(11), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MRAS(4), MYLK(29), MYLK2(9), P4HB(6), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CB(5), PKLR(11), PLCG1(17), PLCG2(23), PTEN(286), PTK2(24), RALA(7), RHO(4), ROCK1(27), ROCK2(15), SHC1(13), SOS1(11), SOS2(15), SRC(3), TERF2IP(3), TLN1(21), TLN2(13), VASP(4), WAS(4), ZYX(2)	57676510	1062	255	904	400	204	291	135	231	186	15	0.796	1.000	1.000
129	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	82	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRB1(2), CSNK1D(14), DRD1(9), DRD2(7), EGF(7), GJA1(5), GJD2(4), GNA11(8), GNAI1(3), GNAI2(2), GNAI3(2), GNAQ(10), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), HTR2B(7), HTR2C(13), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K2(2), MAP2K5(4), MAP3K2(8), MAPK1(3), MAPK3(3), MAPK7(6), NPR1(16), NPR2(15), PDGFA(2), PDGFB(1), PDGFD(11), PDGFRA(56), PDGFRB(20), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), PRKX(3), SOS1(11), SOS2(15), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9)	61069517	987	246	929	388	330	178	132	224	121	2	0.719	1.000	1.000
130	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	136	AKT1(11), AKT2(7), AKT3(7), BCL2L1(1), CBLB(14), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(68), CSF2RB(13), CSF3(2), CSF3R(18), EP300(42), EPO(1), EPOR(2), GH1(4), GH2(4), GHR(12), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL15(1), IL15RA(1), IL19(2), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL9(1), IRF9(6), JAK1(20), JAK3(27), LEP(1), LEPR(15), LIF(1), LIFR(35), MPL(5), MYC(5), OSM(4), OSMR(20), PIAS1(4), PIAS2(4), PIAS3(10), PIAS4(2), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIM1(3), PRL(3), PRLR(8), PTPN11(31), PTPN6(4), SOCS2(2), SOCS5(10), SOCS7(1), SOS1(11), SOS2(15), SPRED1(9), SPRED2(9), SPRY1(9), SPRY2(2), SPRY4(7), STAM(3), STAM2(4), STAT1(15), STAT2(10), STAT3(10), STAT4(10), STAT5A(8), STAT6(4), TPO(29), TSLP(3), TYK2(5)	67076804	950	246	863	325	254	184	131	244	135	2	0.206	1.000	1.000
131	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	76	ABL1(27), ATM(200), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDAN1(7), CDC14A(10), CDC14B(5), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(5), CDC6(6), CDK2(5), CDK4(3), CDKN1A(2), CDKN2A(7), CHEK1(10), DTX4(8), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), EP300(42), ESPL1(22), GSK3B(16), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), HDAC8(3), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MPEG1(6), MPL(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTPRA(5), PTTG1(2), RB1(123), RBL1(18), SKP2(3), TBC1D8(11), TFDP1(10), TGFB1(2)	53283839	929	245	791	329	180	277	94	202	160	16	0.523	1.000	1.000
132	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	58	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2L1(1), CDC42(2), CDK2(5), CDKN1B(4), CDKN2A(7), CREB1(3), CREB3(5), CREB5(5), EBP(5), ERBB4(56), F2RL2(6), GAB1(15), GSK3A(6), GSK3B(16), IGF1(6), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), MYC(5), NOLC1(8), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARD3(11), PARD6A(1), PDK1(5), PIK3CD(10), PPP1R13B(9), PREX1(22), PTEN(286), PTK2(24), PTPN1(10), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SLC2A4(7), SOS1(11), SOS2(15), TSC1(17), TSC2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	34586997	841	245	678	310	150	264	114	170	134	9	0.676	1.000	1.000
133	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	59	APAF1(23), ATM(200), ATR(43), BAI1(11), BID(2), CASP3(3), CASP8(19), CASP9(5), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG1(4), CCNG2(4), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN2A(7), CHEK1(10), CYCS(1), EI24(1), FAS(7), GADD45G(1), GTSE1(2), IGF1(6), MDM2(11), MDM4(6), PPM1D(6), PTEN(286), RCHY1(4), RFWD2(5), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(3), SERPINE1(8), SESN1(5), SESN2(8), SESN3(7), SFN(1), SIAH1(2), STEAP3(6), THBS1(12), TNFRSF10B(4), TP73(5), TSC2(15), ZMAT3(9)	30394265	820	244	636	308	107	305	92	162	137	17	0.748	1.000	1.000
134	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	142	ADORA1(14), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCBP2(9), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CCRL1(4), CCRL2(5), CHML(21), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CMKLR1(5), CNR1(10), CNR2(1), CX3CR1(5), CXCR3(4), CXCR4(6), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2R(11), F2RL2(6), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GPR17(2), GPR173(3), GPR3(3), GPR35(3), GPR37(12), GPR37L1(8), GPR4(6), GPR44(2), GPR50(9), GPR6(7), GPR63(4), GPR77(3), GPR83(6), GPR85(6), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HTR1A(15), HTR1B(11), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LTB4R(1), MAS1(2), MC1R(2), MC3R(13), MC4R(6), MC5R(7), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPN1SW(8), OPN3(6), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OR10A5(3), OR12D3(1), OR1C1(9), OR1F1(4), OR1Q1(4), OR2H1(3), OR7A5(4), OR8B8(5), OXTR(2), P2RY1(5), P2RY10(12), P2RY12(5), P2RY14(9), P2RY2(6), P2RY6(5), PPYR1(5), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), RGR(3), RHO(4), RRH(5), SSTR1(11), SSTR2(4), SSTR4(12), SUCNR1(3), TRHR(7)	52669576	939	240	875	385	358	175	125	186	95	0	0.304	1.000	1.000
135	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	139	ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADK(7), ADSL(13), ADSS(5), ADSSL1(6), AK1(1), AK5(7), AK7(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), FHIT(1), GART(5), GDA(6), GMPR(8), GMPR2(3), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NPR1(16), NPR2(15), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE10A(12), PDE11A(13), PDE1A(8), PDE1C(17), PDE2A(10), PDE3B(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6D(2), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PPAT(5), PRIM1(5), PRIM2(2), PRPS1L1(3), PRPS2(6), PRUNE(3), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), XDH(19)	83872504	1072	240	1021	377	310	177	166	244	174	1	0.316	1.000	1.000
136	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	124	AXIN1(8), BTRC(7), CACYBP(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(4), CHD8(35), CREBBP(68), CSNK1A1(3), CSNK1A1L(8), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(13), CTNNBIP1(1), CUL1(16), CXXC4(2), DAAM1(8), DAAM2(15), DKK1(8), DKK4(5), DVL2(11), DVL3(8), EP300(42), FBXW11(12), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LEF1(9), LRP5(11), LRP6(24), MAP3K7(7), MAPK10(14), MAPK8(11), MAPK9(10), MMP7(8), MYC(5), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NKD1(6), NLK(12), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PORCN(3), PPARD(4), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRICKLE1(18), PRICKLE2(14), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PSEN1(3), RAC1(2), RAC2(1), ROCK1(27), ROCK2(15), RUVBL1(7), SENP2(3), SFRP1(2), SFRP4(5), SFRP5(1), SIAH1(2), SKP1(2), SMAD3(17), TBL1X(8), TBL1XR1(11), TCF7(12), TCF7L1(7), VANGL1(12), VANGL2(9), WIF1(5), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3)	68350442	1038	239	974	381	360	177	119	210	167	5	0.554	1.000	1.000
137	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	72	ABL1(27), ABL2(17), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CBLB(14), CBLC(3), CDKN1A(2), CDKN1B(4), CRKL(5), EGF(7), ELK1(4), ERBB2(28), ERBB3(28), ERBB4(56), EREG(3), GAB1(15), GSK3B(16), HBEGF(1), HRAS(4), JUN(2), MAP2K2(2), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MYC(5), NCK2(4), NRG1(26), NRG2(6), NRG3(14), NRG4(2), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SRC(3), STAT5A(8)	43881700	700	236	634	265	174	154	101	145	125	1	0.826	1.000	1.000
138	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	64	ACP1(5), ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ACVR1C(9), BAIAP2(6), CDC42(2), CREBBP(68), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNND1(19), EP300(42), ERBB2(28), FARP2(12), FER(15), FGFR1(20), FYN(15), IGF1R(17), INSR(20), IQGAP1(24), LEF1(9), LMO7(31), MAP3K7(7), MAPK1(3), MAPK3(3), MLLT4(17), NLK(12), PARD3(11), PTPN1(10), PTPN6(4), PTPRB(19), PTPRF(21), PTPRJ(15), PTPRM(38), PVRL1(7), PVRL2(4), PVRL3(4), PVRL4(10), RAC1(2), RAC2(1), SMAD3(17), SNAI1(5), SORBS1(11), SRC(3), SSX2IP(8), TCF7(12), TCF7L1(7), TGFBR1(17), TGFBR2(24), TJP1(21), VCL(9), WAS(4), WASF1(3), WASF2(5), WASF3(14), WASL(16), YES1(9)	53558223	865	236	790	298	253	171	104	188	147	2	0.220	1.000	1.000
139	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(14), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), MINPP1(4), MIOX(3), OCRL(16), PI4KA(24), PI4KB(5), PIK3C3(25), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14)	35623384	765	234	625	273	176	245	88	148	99	9	0.481	1.000	1.000
140	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGAP1(3), ARHGAP4(7), ARHGEF11(20), BTK(11), CDC42(2), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(14), ITPR1(41), ITPR2(41), ITPR3(39), LIMK1(7), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDK1(5), PIK3CD(10), PIK3CG(36), PITX2(2), PPP1R13B(9), PTEN(286), RACGAP1(5), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), SAG(5), WASF1(3), WASL(16)	33083660	768	233	630	290	137	241	95	170	113	12	0.849	1.000	1.000
141	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	116	ACACA(30), ACACB(37), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBLB(14), CBLC(3), CRKL(5), ELK1(4), EXOC7(3), FBP1(1), FBP2(4), FLOT1(6), FLOT2(2), FOXO1(8), G6PC(4), G6PC2(2), GCK(3), GSK3B(16), GYS1(5), GYS2(13), HRAS(4), IKBKB(7), INPP5D(8), INSR(20), IRS1(17), IRS4(30), LIPE(9), MAP2K2(2), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MKNK1(2), MKNK2(6), PCK1(3), PCK2(6), PDE3A(19), PDE3B(8), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PKLR(11), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R3A(38), PPP1R3B(4), PPP1R3C(4), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCI(24), PRKCZ(3), PRKX(3), PTPN1(10), PTPRF(21), PYGB(15), PYGL(6), PYGM(10), RAPGEF1(19), RHEB(4), RHOQ(6), RPS6(2), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SLC2A4(7), SOCS2(2), SORBS1(11), SOS1(11), SOS2(15), SREBF1(8), TRIP10(4), TSC1(17), TSC2(15)	71564690	936	232	869	334	292	156	123	215	148	2	0.376	1.000	1.000
142	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	98	ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), BCAR1(5), CDC42(2), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNND1(19), CXCL12(2), CXCR4(6), CYBB(4), ESAM(6), EZR(3), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), GRLF1(18), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), ITK(21), JAM2(2), JAM3(9), MAPK12(4), MAPK13(4), MAPK14(7), MLLT4(17), MMP2(12), MMP9(14), MSN(6), MYL2(2), MYL7(1), NCF1(4), NCF2(8), NCF4(4), NOX1(4), NOX3(11), OCLN(2), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(12), RASSF5(6), RHOH(4), ROCK1(27), ROCK2(15), SIPA1(9), TXK(10), VASP(4), VAV1(22), VAV3(27), VCAM1(12), VCL(9)	55956857	832	228	779	311	261	144	86	195	141	5	0.798	1.000	1.000
143	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	62	ADCY1(22), ADCY8(30), ARAF(10), ATF4(2), CACNA1C(32), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CREBBP(68), EP300(42), GNAQ(10), GRIA1(35), GRIA2(23), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K2(2), MAPK1(3), MAPK3(3), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PPP1R1A(1), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15)	48280816	825	227	775	342	276	182	92	166	108	1	0.919	1.000	1.000
144	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(200), CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CREB3(5), CREB3L1(5), CREB3L3(4), CREB3L4(4), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), GBA2(15), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MNAT1(3), MYC(5), MYT1(20), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLE(37), POLE2(5), PRIM1(5), RB1(123), RBL1(18), RPA1(12), RPA2(1), TFDP1(10), TFDP2(4), TNXB(51)	35738657	724	225	616	256	140	203	77	171	118	15	0.423	1.000	1.000
145	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(11), AKT2(7), AKT3(7), BCR(11), BTK(11), CD19(10), CDKN2A(7), DAPP1(3), FLOT1(6), FLOT2(2), GAB1(15), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), PDK1(5), PHF11(3), PITX2(2), PLCG2(23), PPP1R13B(9), PREX1(22), PTEN(286), PTPRC(27), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SAG(5), SYK(5), TEC(8), VAV1(22)	26597281	694	224	572	246	140	240	94	128	84	8	0.368	1.000	1.000
146	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(39), ABCA10(31), ABCA12(66), ABCA13(70), ABCA3(22), ABCA4(31), ABCA5(33), ABCA6(28), ABCA7(21), ABCA8(23), ABCA9(32), ABCB1(29), ABCB10(10), ABCB11(19), ABCB4(23), ABCB5(24), ABCB6(7), ABCB7(6), ABCB8(8), ABCB9(5), ABCC1(20), ABCC10(18), ABCC11(14), ABCC12(22), ABCC2(18), ABCC3(10), ABCC4(24), ABCC5(20), ABCC6(9), ABCC8(21), ABCC9(22), ABCD1(5), ABCD2(18), ABCD3(5), ABCD4(10), ABCG1(7), ABCG2(12), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(16), TAP1(7), TAP2(15)	57548332	848	223	825	259	221	133	99	240	145	10	0.0122	1.000	1.000
147	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	84	AKT1(11), AKT3(7), BCAR1(5), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(8), CAPN3(10), CAPN5(11), CAPN6(13), CAPN7(11), CAPN9(5), CAPNS1(4), CAV2(4), CAV3(3), CDC42(2), CSK(3), DOCK1(22), FYN(15), GIT2(10), ILK(3), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAPK10(14), MAPK12(4), MAPK4(4), MAPK7(6), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAP1B(2), RAPGEF1(19), RHO(4), ROCK1(27), ROCK2(15), SDCCAG8(2), SEPP1(3), SHC1(13), SHC3(5), SORBS1(11), SOS1(11), SRC(3), TLN1(21), TNS1(34), VASP(4), VAV3(27), VCL(9), ZYX(2)	64078650	835	223	787	324	249	125	91	204	159	7	0.939	1.000	1.000
148	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	87	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), AKAP1(7), AKAP10(5), AKAP11(26), AKAP12(30), AKAP2(2), AKAP3(22), AKAP4(14), AKAP5(5), AKAP6(37), AKAP8(7), AKAP9(66), ARHGEF1(13), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(6), GNA13(3), GNA14(10), GNA15(5), GNAI2(2), GNAI3(2), GNAL(4), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(1), GNG4(1), GNG7(2), HRAS(4), IL18BP(1), ITPR1(41), KCNJ3(11), PALM2(1), PDE1A(8), PDE1B(10), PDE1C(17), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PLCB3(14), PPP3CA(3), PPP3CC(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKD3(15), RRAS(2), SLC9A1(9), USP5(9)	58423882	860	222	801	319	260	156	102	191	149	2	0.484	1.000	1.000
149	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADK(7), ADSL(13), ADSS(5), AK1(1), AK5(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), ATP1B1(4), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), FHIT(1), GART(5), GDA(6), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NPR1(16), NPR2(15), NT5C(1), NT5E(6), NT5M(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE1A(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6B(11), PDE6C(10), PDE7B(4), PDE8A(6), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), PPAT(5), PRPS1L1(3), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5)	64614815	845	221	800	288	250	134	118	205	137	1	0.344	1.000	1.000
150	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(51), ASH2L(6), C17orf79(1), CARM1(3), CTCFL(18), DOT1L(9), EED(2), EHMT1(9), EHMT2(7), EZH1(8), EZH2(49), FBXO11(14), HCFC1(11), HSF4(4), JMJD4(1), JMJD6(8), KDM6A(26), MEN1(26), MLL(50), MLL2(59), MLL3(75), MLL4(36), MLL5(26), NSD1(25), OGT(8), PAXIP1(17), PPP1CA(2), PPP1CB(5), PPP1CC(1), PRDM2(34), PRDM7(5), PRDM9(33), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), RBBP5(4), SATB1(16), SETD1A(20), SETD7(7), SETD8(6), SETDB1(18), SETDB2(4), SETMAR(3), SMYD3(4), STK38(7), SUV39H1(4), SUV39H2(6), SUV420H1(13), SUV420H2(1), SUZ12(4), WHSC1(25), WHSC1L1(10)	56764468	809	220	713	260	219	185	66	171	157	11	0.367	1.000	1.000
151	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	74	ACVR1(6), ACVRL1(7), AKT1(11), AURKB(6), BUB1(13), CDKL1(3), CDKL2(16), CDS2(9), CLK1(8), CLK2(3), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MAP3K10(10), MOS(8), NEK1(20), NEK3(9), OCRL(16), PAK4(6), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CB(5), PIK3CG(36), PIM2(1), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23), PLK3(3), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKG1(12), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KB1(9), STK11(36), TGFBR1(17), VRK1(6)	51756005	805	220	724	283	248	161	102	172	120	2	0.449	1.000	1.000
152	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	43	AKT1(11), AKT2(7), AKT3(7), BRD4(21), CAP1(4), CDC42(2), CDKN2A(7), F2RL2(6), FLOT1(6), FLOT2(2), GSK3A(6), GSK3B(16), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), LNPEP(21), MAPK1(3), MAPK3(3), PARD3(11), PARD6A(1), PDK1(5), PIK3CD(10), PPYR1(5), PTEN(286), PTPN1(10), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SERPINB6(2), SFN(1), SHC1(13), SLC2A4(7), SORBS1(11), SOS1(11), SOS2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	25198396	642	218	502	214	118	225	76	128	86	9	0.138	1.000	1.000
153	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	68	ARAF(10), C7orf16(11), CACNA1A(27), CRHR1(4), GNA11(8), GNA12(6), GNA13(3), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAZ(3), GRIA1(35), GRIA2(23), GRIA3(11), GRID2(25), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), IGF1(6), IGF1R(17), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP2K2(2), MAPK1(3), MAPK3(3), NOS1(23), NOS3(21), NPR1(16), NPR2(15), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), RYR1(58)	52563660	858	217	805	340	297	138	110	187	124	2	0.845	1.000	1.000
154	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	87	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), CREB3(5), CREB3L1(5), CREB3L2(4), CREB3L3(4), CREB3L4(4), CREBBP(68), DCT(17), DVL2(11), DVL3(8), EDN1(3), EDNRB(13), EP300(42), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GSK3B(16), HRAS(4), KITLG(3), LEF1(9), MAP2K2(2), MAPK1(3), MAPK3(3), MC1R(2), MITF(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), POMC(4), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), TCF7(12), TCF7L1(7), TYR(9), TYRP1(6), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3)	46929709	771	217	733	320	297	137	91	148	98	0	0.737	1.000	1.000
155	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	74	AIFM1(11), AKT1(11), AKT2(7), AKT3(7), APAF1(23), ATM(200), BAD(1), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CAPN1(2), CAPN2(8), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CSF2RB(13), CYCS(1), DFFA(4), DFFB(2), ENDOG(3), FADD(1), FAS(7), FASLG(3), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL3(6), IRAK1(6), IRAK2(11), IRAK3(9), IRAK4(6), MAP3K14(6), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), NTRK1(16), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), RIPK1(7), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFRSF1A(4), TNFSF10(2), TRAF2(8)	38633361	621	215	546	244	140	158	66	139	112	6	0.945	1.000	1.000
156	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	84	ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ATF4(2), CACNA1C(32), CACNA1D(28), CACNA1F(35), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDC42(2), CGA(2), ELK1(4), FSHB(4), GNA11(8), GNAQ(10), GNRH1(4), GNRHR(9), HBEGF(1), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), LHB(3), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK9(10), MMP14(6), MMP2(12), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLD1(16), PLD2(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(15), PRKX(3), PTK2B(13), SOS1(11), SOS2(15), SRC(3)	59773987	878	213	839	307	283	150	113	203	127	2	0.228	1.000	1.000
157	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	52	BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BTRC(7), CSNK1A1(3), CSNK1A1L(8), CSNK1D(14), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(6), DHH(4), FBXW11(12), GLI1(19), GLI2(22), GLI3(37), GSK3B(16), HHIP(15), IHH(5), LRP2(114), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(130), PTCH2(19), RAB23(3), SHH(3), SMO(11), STK36(16), SUFU(5), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3)	28066999	615	212	539	225	203	140	67	119	83	3	0.428	1.000	1.000
158	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	79	ACVR1(6), ACVR1C(9), ACVR2B(12), ACVRL1(7), AMHR2(4), BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BMPR1B(14), CHRD(14), COMP(6), CREBBP(68), CUL1(16), DCN(7), E2F4(2), E2F5(6), EP300(42), FST(4), GDF5(11), GDF6(6), ID1(2), ID4(1), IFNG(3), INHBA(17), INHBB(3), INHBC(3), INHBE(2), LEFTY1(2), LEFTY2(1), LTBP1(20), MAPK1(3), MAPK3(3), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), RBL1(18), RBL2(22), ROCK1(27), ROCK2(15), RPS6KB1(9), RPS6KB2(4), SKP1(2), SMAD1(10), SMAD3(17), SMAD5(3), SMAD7(1), SMAD9(5), SMURF1(7), SMURF2(6), SP1(6), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNF(1), ZFYVE16(20), ZFYVE9(18)	45919183	698	209	651	281	230	116	84	150	112	6	0.932	1.000	1.000
159	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	108	ARAF(10), BID(2), CASP3(3), CD244(7), CD247(3), CD48(2), FAS(7), FASLG(3), FCGR3A(4), FCGR3B(2), FYN(15), GZMB(4), HCST(2), HLA-C(13), HLA-E(4), HRAS(4), ICAM1(4), ICAM2(5), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), ITGAL(18), ITGB2(16), KIR2DL1(9), KIR2DL4(5), KIR3DL1(6), KIR3DL2(6), KLRC1(2), KLRC2(2), KLRC3(7), KLRD1(3), KLRK1(7), LAT(2), LCK(8), LCP2(9), MAP2K2(2), MAPK1(3), MAPK3(3), MICB(1), NCR1(2), NCR2(2), NCR3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), PAK1(10), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRF1(7), PRKCA(5), PRKCG(19), PTK2B(13), PTPN11(31), PTPN6(4), RAC1(2), RAC2(1), SH2D1A(3), SH2D1B(1), SH3BP2(6), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SYK(5), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(2), ULBP1(7), ULBP2(2), ULBP3(5), VAV1(22), VAV3(27), ZAP70(12)	49476575	702	209	637	250	197	132	87	156	128	2	0.459	1.000	1.000
160	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	85	ACTB(4), BAD(1), BCL2(2), CABIN1(22), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(6), CD3E(2), CD69(2), CDKN1A(2), CNR1(10), CREBBP(68), CSNK2A1(7), CSNK2B(2), CTLA4(4), EGR2(14), EGR3(6), EP300(42), FCER1A(5), FCGR3A(4), FOS(4), FOSL1(1), GATA4(4), GRLF1(18), GSK3A(6), GSK3B(16), HRAS(4), ICOS(2), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL13(2), IL1B(4), IL2(4), IL2RA(3), IL3(6), IL4(5), IL6(5), IL8(5), ITK(21), KPNA5(12), MAPK14(7), MAPK8(11), MAPK9(10), MEF2A(5), MEF2D(3), MYF5(5), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB2(4), NFKBIB(5), NFKBIE(4), NPPB(4), NUP214(18), OPRD1(6), P2RX7(12), PAK1(10), PIN1(2), PPIA(1), PPP3CB(10), PPP3CC(5), PPP3R1(3), PTPRC(27), RELA(9), RPL13A(1), SFN(1), SLA(8), SP1(6), SP3(10), TGFB1(2), TNF(1), TRAF2(8), TRPV6(14), VAV1(22), VAV3(27), XPO5(8)	42888283	661	208	619	240	198	161	76	135	91	0	0.373	1.000	1.000
161	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHX58(4), ENPP1(17), ENPP3(10), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), G6PC(4), G6PC2(2), GAA(14), GANC(8), GBA(4), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), IFIH1(20), LYZL1(4), MGAM(26), MOV10L1(16), NUDT5(1), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SI(24), SKIV2L2(11), SMARCA2(19), SMARCA5(13), TREH(6), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UXS1(8)	64682837	798	208	738	240	226	141	97	180	151	3	0.0787	1.000	1.000
162	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	29	ACTA1(12), CRKL(5), DOCK1(22), ELK1(4), FOS(4), GAB1(15), HGF(13), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K2(2), MAP4K1(6), MAPK1(3), MAPK3(3), MAPK8(11), PAK1(10), PTEN(286), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAP1A(1), RAP1B(2), RASA1(20), SOS1(11), SRC(3), STAT3(10)	18274597	543	206	411	221	63	227	64	115	66	8	0.891	1.000	1.000
163	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	102	A4GNT(5), ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG6(5), ALG8(12), ALG9(7), B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT5(4), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(9), CHST11(4), CHST12(4), CHST14(1), CHST2(11), CHST3(6), CHST4(6), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(12), EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), FUT11(2), FUT8(10), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GANAB(12), GCNT1(7), GCNT3(4), GCNT4(12), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), NDST1(9), NDST2(9), NDST3(15), NDST4(13), OGT(8), RPN1(4), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(5), STT3B(9), UST(10), XYLT1(12)	53181188	735	203	691	272	247	125	85	158	120	0	0.868	1.000	1.000
164	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	81	AKT1(11), AKT2(7), AKT3(7), BCL10(8), CBLB(14), CBLC(3), CD247(3), CD28(4), CD3D(4), CD3E(2), CD4(4), CD40LG(10), CD8A(1), CD8B(4), CDC42(2), CDK4(3), CTLA4(4), FOS(4), FYN(15), GRAP2(3), HRAS(4), ICOS(2), IFNG(3), IKBKB(7), IKBKG(2), IL10(1), IL2(4), IL4(5), ITK(21), JUN(2), LAT(2), LCK(8), LCP2(9), MALT1(12), MAP3K14(6), MAP3K8(4), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDCD1(2), PDK1(5), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCQ(15), PTPN6(4), PTPRC(27), RASGRP1(7), SOS1(11), SOS2(15), TEC(8), TNF(1), VAV1(22), VAV3(27), ZAP70(12)	44051292	599	203	555	205	166	123	78	128	104	0	0.246	1.000	1.000
165	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(22), BDKRB1(3), BDKRB2(4), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(14), C2(6), C3(23), C3AR1(10), C4A(3), C4BPA(6), C4BPB(1), C5(20), C5AR1(7), C6(24), C7(10), C8A(11), C8B(22), C8G(1), C9(11), CD46(3), CD55(7), CFB(5), CFH(25), CFI(9), CPB2(10), CR1(19), CR2(20), F10(5), F11(8), F12(5), F13A1(12), F13B(10), F2(9), F2R(11), F3(1), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), KNG1(8), MASP1(19), MASP2(10), MBL2(3), PLAT(10), PLAU(6), PLAUR(7), PLG(23), PROC(3), PROS1(9), SERPINA1(6), SERPINA5(8), SERPINC1(8), SERPIND1(5), SERPINE1(8), SERPINF2(4), SERPING1(5), TFPI(6), THBD(3), VWF(30)	48091564	693	202	656	256	173	113	103	171	129	4	0.804	1.000	1.000
166	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(4), AKT1(11), AKT2(7), AKT3(7), BAD(1), BTK(11), CDKN2A(7), DAPP1(3), GSK3A(6), GSK3B(16), IARS(9), IGFBP1(2), INPP5D(8), PDK1(5), PPP1R13B(9), PTEN(286), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SOS1(11), SOS2(15), TEC(8), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3)	16962075	509	201	389	181	74	207	55	94	70	9	0.323	1.000	1.000
167	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	46	ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(13), CREBBP(68), DUSP1(6), EHHADH(13), EP300(42), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(3), ME1(11), MRPL11(1), MYC(5), NCOA1(13), NCOR1(30), NCOR2(38), NFKBIA(1), NR1H3(16), NR2F1(5), NRIP1(17), PDGFA(2), PPARA(7), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PTGS2(9), RB1(123), RELA(9), RXRA(8), SP1(6), SRA1(2), STAT5A(8), TNF(1)	28903689	536	198	446	189	115	140	54	110	109	8	0.540	1.000	1.000
168	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(200), BMPR1B(14), CCND2(3), CDK4(3), CDKN1B(4), DAZL(2), DMC1(6), EGR1(11), ESR2(8), FSHR(16), GJA4(3), INHA(6), MLH1(62), MSH5(7), NCOR1(30), NR5A1(5), NRIP1(17), PGR(15), PRLR(8), PTGER2(2), SMPD1(9), VDR(3), ZP2(14)	17104668	448	197	365	157	86	137	42	89	88	6	0.484	1.000	1.000
169	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(27), ATM(200), ATR(43), CCNA1(16), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), DHFR(1), GSK3B(16), HDAC1(5), RB1(123), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2)	15235391	497	196	387	192	84	173	38	97	88	17	0.757	1.000	1.000
170	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	19	ATM(200), ATR(43), BRCA1(29), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(10), EP300(42), MDM2(11), MYT1(20), PRKDC(80), RPS6KA1(9), YWHAH(3), YWHAQ(1)	20331472	488	196	405	185	87	150	50	98	93	10	0.817	1.000	1.000
171	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(11), EIF4A2(10), EIF4G1(17), EIF4G2(16), EIF4G3(16), GHR(12), IRS1(17), MAPK1(3), MAPK14(7), MAPK3(3), MKNK1(2), PABPC1(8), PDK2(8), PDPK1(4), PRKCA(5), PTEN(286), RPS6KB1(9)	12492764	434	195	313	165	47	189	55	84	51	8	0.628	1.000	1.000
172	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	66	ACACB(37), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ADIPOR1(2), ADIPOR2(5), AKT1(11), AKT2(7), AKT3(7), CAMKK1(2), CAMKK2(8), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), G6PC(4), G6PC2(2), IKBKB(7), IKBKG(2), IRS1(17), IRS4(30), JAK1(20), JAK3(27), LEP(1), LEPR(15), MAPK10(14), MAPK8(11), MAPK9(10), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NPY(5), PCK1(3), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKCQ(15), PTPN11(31), RELA(9), RXRA(8), RXRB(7), RXRG(10), SLC2A1(5), SLC2A4(7), STAT3(10), STK11(36), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5)	38961653	603	194	536	190	173	138	86	124	82	0	0.0204	1.000	1.000
173	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	48	ACTG1(6), APAF1(23), ARHGDIB(5), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), GSN(4), LMNB1(9), LMNB2(2), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK8(11), MDM2(11), NFKB1(8), NFKBIA(1), NUMA1(21), PAK2(14), PRKCD(15), PRKDC(80), PSEN1(3), PSEN2(6), PTK2(24), RASA1(20), RB1(123), RELA(9), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8)	32896230	571	193	485	196	116	162	52	121	110	10	0.565	1.000	1.000
174	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	75	ANPEP(16), CD14(6), CD19(10), CD1A(4), CD1B(5), CD1C(3), CD1D(5), CD2(7), CD22(15), CD33(2), CD34(7), CD36(3), CD37(4), CD38(4), CD3D(4), CD3E(2), CD4(4), CD44(5), CD5(7), CD55(7), CD7(4), CD8A(1), CD8B(4), CD9(3), CR1(19), CR2(20), CSF1(4), CSF1R(15), CSF3(2), CSF3R(18), DNTT(11), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(27), FLT3LG(1), GP5(8), GP9(1), HLA-DRB1(6), HLA-DRB5(2), IL11(6), IL11RA(4), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL2RA(3), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL7(3), IL7R(12), ITGA1(12), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGAM(13), ITGB3(12), KITLG(3), MME(23), MS4A1(7), TFRC(5), THPO(5), TNF(1), TPO(29)	39161151	544	192	510	196	160	90	76	138	76	4	0.266	1.000	1.000
175	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	74	ATF2(6), CREB1(3), DAXX(14), ELK1(4), FOS(4), HRAS(4), IKBKB(7), JUN(2), MAP2K2(2), MAP2K3(8), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP3K9(9), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAP4K5(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK4(4), MAPK7(6), MAPK8(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MKNK2(6), MYC(5), NFKB1(8), NFKBIA(1), PAK1(10), PAK2(14), RAC1(2), RELA(9), RIPK1(7), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KB1(9), RPS6KB2(4), SHC1(13), SP1(6), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8)	43121185	612	191	563	187	175	110	87	122	116	2	0.0959	1.000	1.000
176	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(11), EIF4A2(10), EIF4B(4), EIF4G1(17), EIF4G2(16), EIF4G3(16), FKBP1A(1), MKNK1(2), PDK2(8), PDPK1(4), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9), TSC1(17), TSC2(15)	11873983	421	191	302	163	49	193	44	72	55	8	0.647	1.000	1.000
177	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ALG6(5), CCKBR(12), CCR2(7), CCR3(9), CCR5(11), CELSR1(27), CELSR2(31), CELSR3(27), CHRM2(25), CHRM3(21), CIDEB(1), CXCR3(4), EDNRA(8), EMR2(7), EMR3(18), F2R(11), FSHR(16), GHRHR(2), GNRHR(9), GPR116(16), GPR132(6), GPR133(15), GPR143(4), GPR17(2), GPR18(3), GPR55(2), GPR56(5), GPR61(9), GPR77(3), GPR84(5), GPR88(4), GRM1(32), GRPR(4), HRH4(6), LGR6(8), LPHN2(26), LPHN3(26), NTSR1(5), OR2M4(15), OR8G1(3), OR8G2(9), PTGFR(7), SMO(11), SSTR2(4), TAAR5(8), VN1R1(7)	29102018	496	189	450	176	157	94	49	116	79	1	0.363	1.000	1.000
178	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(11), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), GSK3B(16), IGF1(6), IGF1R(17), INPPL1(14), PDK2(8), PDPK1(4), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9)	8271910	397	189	281	159	43	194	42	65	45	8	0.825	1.000	1.000
179	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	18	ATM(200), ATR(43), BRCA1(29), BRCA2(77), CHEK1(10), FANCA(9), FANCC(8), FANCE(4), FANCF(3), FANCG(5), HUS1(7), MRE11A(15), RAD1(2), RAD17(7), RAD50(23), RAD9A(1), TREX1(3)	20866140	446	186	351	179	57	143	38	96	102	10	0.974	1.000	1.000
180	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CDK2(5), CDK4(3), CHEK1(10), MYT1(20), RB1(123), YWHAH(3)	8472620	391	184	295	135	64	147	27	80	59	14	0.333	1.000	1.000
181	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(11), BCAR1(5), CDKN1B(4), ILK(3), ITGB1(12), MAPK1(3), MAPK3(3), PDK2(8), PDPK1(4), PTEN(286), PTK2(24), SHC1(13), SOS1(11)	7463883	387	183	268	149	28	186	43	71	50	9	0.697	1.000	1.000
182	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	90	AKT1(11), AKT2(7), AKT3(7), CASP8(19), CCL4(1), CD14(6), CD40(6), CD80(4), CD86(2), CXCL10(1), CXCL11(3), CXCL9(6), FADD(1), FOS(4), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IKBKB(7), IKBKE(8), IKBKG(2), IL12A(1), IL12B(1), IL1B(4), IL6(5), IL8(5), IRAK1(6), IRAK4(6), IRF3(2), IRF5(6), JUN(2), LBP(7), LY96(4), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K7(7), MAP3K8(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), RAC1(2), RELA(9), RIPK1(7), SPP1(4), STAT1(15), TBK1(11), TICAM1(15), TIRAP(5), TLR1(8), TLR2(7), TLR3(13), TLR4(15), TLR5(7), TLR6(12), TLR7(15), TLR8(11), TLR9(12), TNF(1), TOLLIP(5), TRAF3(10), TRAF6(4)	40845967	551	182	525	185	136	94	68	148	104	1	0.465	1.000	1.000
183	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(11), AKT2(7), AKT3(7), BPNT1(9), ILK(3), MAPK1(3), MAPK3(3), PDK1(5), PIK3CD(10), PTEN(286), PTK2B(13), RBL2(22), SHC1(13), SOS1(11)	8947690	403	182	284	148	38	183	45	77	51	9	0.684	1.000	1.000
184	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(23), ATM(200), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDKN1A(2), MDM2(11), PCNA(2), RB1(123), TIMP3(10)	8896181	389	176	290	146	55	149	28	82	61	14	0.587	1.000	1.000
185	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	60	ADAM10(8), ADAM17(11), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CDC42(2), CSK(3), CXCL1(1), F11R(4), GIT1(3), HBEGF(1), IGSF5(14), IKBKB(7), IKBKG(2), IL8(5), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP3K14(6), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK8(11), MAPK9(10), NFKB1(8), NFKB2(4), NFKBIA(1), NOD1(9), PAK1(10), PLCG1(17), PLCG2(23), PTPN11(31), PTPRZ1(37), RAC1(2), RELA(9), SRC(3), TCIRG1(6), TJP1(21)	31609484	419	174	374	144	109	110	55	87	58	0	0.277	1.000	1.000
186	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(11), APAF1(23), ATM(200), BAD(1), BCL2(2), BCL2L1(1), BID(2), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CYCS(1), EIF2S1(3), PRKCA(5), PTK2(24), PXN(2), STAT1(15), TLN1(21)	13685327	324	172	265	143	57	109	32	66	53	7	0.983	1.000	1.000
187	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	35	AKT1(11), ASAH1(4), ATF1(5), CAMP(1), CREB1(3), CREB3(5), CREB5(5), CREBBP(68), CRKL(5), DAG1(8), EGR1(11), EGR2(14), EGR3(6), EGR4(3), ELK1(4), FRS2(4), GNAQ(10), JUN(2), MAP1B(38), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), NTRK1(16), OPN1LW(3), PIK3C2G(19), PIK3CD(10), PTPN11(31), RPS6KA3(13), SHC1(13), SRC(3), TERF2IP(3)	21169592	375	171	339	166	85	80	57	82	68	3	0.983	1.000	1.000
188	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(5), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CFLAR(2), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNB1(9), LMNB2(2), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), PTPN13(20), RB1(123), RIPK2(5), SPTAN1(25)	20343617	399	169	333	143	59	118	37	98	77	10	0.790	1.000	1.000
189	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	62	AKT1(11), AKT2(7), AKT3(7), BTK(11), FCER1A(5), FYN(15), GAB2(9), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(8), LAT(2), LCP2(9), LYN(13), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MS4A2(3), PDK1(5), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PRKCA(5), PRKCD(15), PRKCE(4), RAC1(2), RAC2(1), SOS1(11), SOS2(15), SYK(5), TNF(1), VAV1(22), VAV3(27)	30808718	436	169	414	150	131	90	58	100	57	0	0.233	1.000	1.000
190	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(27), ATM(200), BRCA1(29), CDKN1A(2), CHEK1(10), JUN(2), MAPK8(11), MDM2(11), MRE11A(15), NFKB1(8), NFKBIA(1), RAD50(23), RBBP8(14), RELA(9), TP73(5)	14272232	367	168	294	159	58	127	29	68	78	7	0.994	1.000	1.000
191	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(7), CDC40(6), CLK2(3), CLK3(7), COL2A1(19), CPSF1(14), CPSF2(10), CPSF3(8), CPSF4(4), CSTF1(4), CSTF2(2), CSTF2T(11), CSTF3(11), DDIT3(4), DDX1(14), DDX20(6), DHX15(8), DHX16(18), DHX38(12), DHX9(12), DICER1(23), DNAJC8(5), FUS(2), GIPC1(4), METTL3(5), NCBP1(8), NCBP2(2), NONO(12), NUDT21(1), NXF1(9), PABPN1(2), PAPOLA(7), PHF5A(1), POLR2A(12), PPM1G(3), PRPF18(4), PRPF3(9), PRPF4(9), PRPF4B(16), PRPF8(17), PSKH1(2), PTBP1(4), PTBP2(13), RBM17(6), RBM5(12), RNGTT(7), RNMT(5), RNPS1(1), SF3A1(10), SF3A2(4), SF3A3(1), SF3B1(17), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(2), SNRPA1(2), SNRPB(2), SNRPB2(3), SNRPD1(2), SNRPD3(1), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(8), SRPK2(9), SRRM1(15), SUPT5H(19), TXNL4A(2), U2AF1(3), U2AF2(6), XRN2(10)	52249220	531	167	503	175	140	80	59	132	119	1	0.866	1.000	1.000
192	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	39	ADAM17(11), APH1A(2), CREBBP(68), CTBP1(5), CTBP2(13), DLL1(6), DLL3(6), DLL4(5), DTX1(6), DTX2(8), DTX3(2), DTX3L(10), DTX4(8), DVL2(11), DVL3(8), EP300(42), HDAC1(5), HDAC2(8), HES1(2), JAG1(15), LFNG(5), MAML1(10), MAML2(8), MAML3(4), MFNG(1), NCOR2(38), NCSTN(6), NOTCH2(29), NOTCH3(27), NOTCH4(15), NUMB(10), NUMBL(6), PSEN1(3), PSEN2(6), PSENEN(2), PTCRA(4), RBPJL(11), RFNG(1), SNW1(9)	28600583	436	166	400	201	131	84	56	72	92	1	0.996	1.000	1.000
193	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	59	AGTR1(12), ATP8A1(11), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CX3CR1(5), CXCR3(4), CXCR4(6), CXCR6(1), EDNRA(8), EDNRB(13), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(3), GRPR(4), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), NMBR(3), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), PPYR1(5), SSTR1(11), SSTR2(4), SSTR4(12), TAC4(4), TACR1(9), TACR2(4), TACR3(11), TRHR(7)	23251323	403	166	377	170	137	81	46	97	42	0	0.704	1.000	1.000
194	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	51	AXIN1(8), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), DVL2(11), DVL3(8), FBXW2(5), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LDLR(9), MAPK10(14), MAPK9(10), MYC(5), PAFAH1B1(6), PLAU(6), PPP2R5C(5), PPP2R5E(8), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), RAC1(2), SFRP4(5), TCF7(12), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4)	23055717	402	166	374	148	146	89	37	65	64	1	0.335	1.000	1.000
195	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(12), AKT1(11), BDKRB2(4), CALM2(1), CALM3(1), CHRM1(4), CHRNA1(9), FLT1(34), FLT4(16), KDR(38), NOS3(21), PDE2A(10), PDE3A(19), PDE3B(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKG1(12), PRKG2(10), RYR2(122), SLC7A1(6), SYT1(14), TNNI1(2)	19429179	379	165	362	140	106	79	47	92	53	2	0.551	1.000	1.000
196	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	25	ARHGDIB(5), CASP2(8), CASP3(3), CASP8(19), CRADD(3), DFFA(4), DFFB(2), FADD(1), JUN(2), LMNB1(9), LMNB2(2), MADD(22), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), RB1(123), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TRAF2(8)	18535524	388	165	324	132	73	111	31	86	76	11	0.539	1.000	1.000
197	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	51	AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CAT(7), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADHA(10), KMO(13), KYNU(8), MAOA(5), MAOB(6), SDS(3), TDO2(8), TPH1(2), WARS(3), WARS2(6)	27321782	386	165	367	113	132	73	40	98	42	1	0.0249	1.000	1.000
198	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(35), AR(20), ESR1(20), ESR2(8), HNF4A(8), NPM1(2), NR0B1(10), NR1D1(7), NR1D2(7), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(3), NR2C2(11), NR2E1(12), NR2F1(5), NR2F2(10), NR3C1(8), NR4A1(3), NR4A2(13), NR5A1(5), NR5A2(9), PGR(15), PPARA(7), PPARD(4), PPARG(4), RARA(5), RARB(18), RARG(10), ROR1(19), RORA(6), RORC(5), RXRA(8), RXRB(7), RXRG(10), THRA(6), THRB(14), VDR(3)	20201748	358	163	338	124	123	60	45	76	52	2	0.363	1.000	1.000
199	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	67	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1C1(2), AKR1C2(2), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), CYP1A1(9), CYP1A2(10), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2F1(6), CYP2S1(7), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7)	28509286	385	162	348	108	103	70	42	101	68	1	0.0392	1.000	1.000
200	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	54	AKT1(11), AKT2(7), AKT3(7), BCL10(8), BLNK(1), BTK(11), CD19(10), CD22(15), CD72(3), CD79A(6), CD79B(2), CR2(20), FCGR2B(2), FOS(4), GSK3B(16), HRAS(4), IFITM1(2), IKBKB(7), IKBKG(2), INPP5D(8), JUN(2), LILRB3(6), LYN(13), MALT1(12), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RASGRP3(8), SYK(5), VAV1(22), VAV3(27)	31655590	417	162	394	133	131	72	58	90	66	0	0.0641	1.000	1.000
201	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	14	ABCB1(29), AKT1(11), ATM(200), CDKN1A(2), CPB2(10), CSNK1A1(3), CSNK1D(14), FHL2(2), HIF1A(14), MAPK8(11), MDM2(11), NFKBIB(5), NQO1(1)	9461535	313	162	255	113	49	109	30	69	50	6	0.595	1.000	1.000
202	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), CARM1(3), DBH(8), DCT(17), DDC(5), ECH1(2), ESCO1(16), ESCO2(13), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HEMK1(1), HGD(5), HPD(6), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), MYST3(28), MYST4(25), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SH3GLB1(5), TAT(14), TPO(29), TYR(9), TYRP1(6), WBSCR22(2)	30007730	403	161	360	150	124	80	46	98	54	1	0.576	1.000	1.000
203	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(7), ACADL(4), ACADM(9), ACOX1(11), ACOX2(7), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP27A1(4), CYP4A11(7), CYP4A22(13), CYP7A1(13), CYP8B1(9), DBI(2), EHHADH(13), FABP1(2), FABP2(8), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FADS2(10), GK(5), GK2(13), HMGCS2(5), ILK(3), LPL(12), ME1(11), MMP1(5), NR1H3(16), PCK1(3), PCK2(6), PDPK1(4), PLTP(10), PPARA(7), PPARD(4), PPARG(4), RXRA(8), RXRB(7), RXRG(10), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(6), SLC27A4(3), SLC27A5(7), SLC27A6(15), SORBS1(11), UBC(6), UCP1(8)	32916919	442	161	412	125	134	59	71	110	68	0	0.0102	1.000	1.000
204	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	41	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), BCR(11), BLNK(1), BTK(11), CD19(10), CD22(15), CR2(20), CSK(3), DAG1(8), FLOT1(6), FLOT2(2), GSK3A(6), GSK3B(16), INPP5D(8), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP4K1(6), MAPK1(3), MAPK3(3), NFATC2(10), PDK1(5), PIK3CD(10), PLCG2(23), PPP1R13B(9), PPP3CA(3), PPP3CB(10), PPP3CC(5), PTPRC(27), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22)	32999501	459	161	438	138	145	83	65	95	70	1	0.0194	1.000	1.000
205	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	55	AADAT(1), AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), AFMID(2), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CARM1(3), CAT(7), CYP1A1(9), CYP1A2(10), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADH(2), HADHA(10), HEMK1(1), HSD17B10(2), HSD17B4(9), INMT(3), KMO(13), KYNU(8), LCMT1(1), LCMT2(6), LNX1(14), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), NFX1(8), OGDH(13), OGDHL(12), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), TDO2(8), TPH1(2), TPH2(9), WARS(3), WARS2(6), WBSCR22(2)	30207186	362	160	345	126	116	66	46	90	44	0	0.374	1.000	1.000
206	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	60	AKT1(11), AKT2(7), AKT3(7), BAD(1), CASP9(5), CDC42(2), HRAS(4), KDR(38), MAP2K2(2), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPKAPK2(4), MAPKAPK3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NOS3(21), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCA(5), PRKCG(19), PTGS2(9), PTK2(24), PXN(2), RAC1(2), RAC2(1), SH2D2A(4), SHC2(2), SPHK1(2), SPHK2(5), SRC(3), VEGFA(5)	30992183	410	159	381	167	140	62	52	85	71	0	0.867	1.000	1.000
207	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(8), EIF1(2), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), ELAVL1(5), FLT1(34), FLT4(16), HIF1A(14), HRAS(4), KDR(38), NOS3(21), PLCG1(17), PRKCA(5), PTK2(24), PXN(2), SHC1(13), VHL(83)	14802116	326	159	264	134	57	108	43	62	55	1	0.937	1.000	1.000
208	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(29), CARM1(3), CCND1(2), CREBBP(68), EP300(42), ERCC3(18), ESR1(20), GRIP1(12), GTF2A1(5), GTF2E1(13), GTF2F1(5), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), MEF2C(15), NCOR2(38), NR0B1(10), NRIP1(17), PELP1(11), POLR2A(12), SRA1(2), TBP(2)	23481084	379	157	340	172	102	76	40	68	93	0	0.998	1.000	1.000
209	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	60	ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CHPT1(3), CRLS1(1), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), ESCO1(16), ESCO2(13), ETNK1(3), GNPAT(17), GPAM(4), GPD1(3), GPD1L(4), GPD2(10), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(28), MYST4(25), NAT6(2), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(11), SH3GLB1(5)	32260243	398	155	368	158	113	74	58	99	53	1	0.871	1.000	1.000
210	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	34	AKT1(11), ATF2(6), CDC42(2), DLD(3), DUSP10(5), DUSP4(6), GAB1(15), GCK(3), IL1R1(6), JUN(2), MAP2K5(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK10(14), MAPK7(6), MAPK8(11), MAPK9(10), MYEF2(14), NFATC3(13), NR2C2(11), PAPPA(33), SHC1(13), TRAF6(4), ZAK(8)	24306130	365	155	321	98	97	58	50	80	78	2	0.0603	1.000	1.000
211	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CHEK1(10), MYT1(20), YWHAH(3)	6812035	260	153	209	92	48	91	20	53	42	6	0.505	1.000	1.000
212	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(6), AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PRIM1(5), PRIM2(2), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), TK1(2), TK2(2), TXNRD1(9), TXNRD2(8), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UPB1(7), UPP1(5), UPP2(4), UPRT(6)	42323224	484	153	466	149	127	84	77	122	74	0	0.0440	1.000	1.000
213	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	53	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AGK(6), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CEL(12), DAK(7), DGAT1(5), DGAT2(4), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), GK(5), GK2(13), GLA(7), GLB1(9), GPAM(4), LCT(39), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(12), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	28928912	393	153	368	150	109	58	58	123	44	1	0.675	1.000	1.000
214	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATM(200), ATR(43), CDC25C(5), CHEK1(10), YWHAH(3)	7651852	261	153	200	95	38	89	21	49	55	9	0.703	1.000	1.000
215	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(68), DAXX(14), HRAS(4), PAX3(23), PML(11), RARA(5), RB1(123), SIRT1(7), SP100(14), TNF(1), TNFRSF1A(4), TNFRSF1B(1)	9000330	275	153	217	105	61	95	23	47	41	8	0.587	1.000	1.000
216	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	39	AKT1(11), AKT2(7), AKT3(7), CAB39(2), EIF4B(4), FIGF(4), HIF1A(14), IGF1(6), MAPK1(3), MAPK3(3), PDPK1(4), PGF(3), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PRKAA1(8), PRKAA2(15), RHEB(4), RICTOR(24), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), STK11(36), TSC1(17), TSC2(15), ULK2(14), ULK3(3), VEGFA(5), VEGFC(11)	22415002	356	152	328	125	104	71	46	77	56	2	0.471	1.000	1.000
217	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), F10(5), F11(8), F12(5), F2(9), F2R(11), F5(30), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), PROC(3), PROS1(9), SERPINC1(8), SERPING1(5)	23443152	331	152	309	132	72	62	48	88	59	2	0.705	1.000	1.000
218	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	61	APAF1(23), BAD(1), BAK1(2), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), BIRC2(5), BIRC3(11), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), GZMB(4), HELLS(12), IKBKB(7), IKBKG(2), IRF1(5), IRF2(10), IRF3(2), IRF4(3), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP3K1(18), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), NFKBIB(5), NFKBIE(4), PLEKHG5(8), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFSF10(2), TP73(5), TRAF1(5), TRAF2(8), TRAF3(10)	26418395	341	150	310	114	81	67	42	73	78	0	0.530	1.000	1.000
219	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	89	ANK2(71), B3GALT4(4), CDR1(5), DGKI(18), FAU(1), IL6ST(14), MRPL19(4), PIGK(10), RPL10(2), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(5), RPL6(2), RPL7(3), RPL7A(1), RPL8(3), RPL9(3), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(1), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS4X(1), RPS5(2), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), RPS7(1), RPS9(3), RPSA(1), SLC36A2(3), TBC1D10C(8), TSPAN9(4), UBA52(3), UBB(2), UBC(6)	25701499	326	150	307	94	83	65	45	78	53	2	0.187	1.000	1.000
220	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHFR(1), DHX58(4), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), FPGS(4), GGH(1), IFIH1(20), MOV10L1(16), NUDT5(1), QDPR(2), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SKIV2L2(11), SMARCA2(19), SMARCA5(13), SPR(7)	31802044	417	149	375	138	132	77	48	86	72	2	0.370	1.000	1.000
221	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	44	ACTA1(12), AGT(10), AKT1(11), CALM2(1), CALM3(1), CALR(1), CAMK1G(5), CAMK4(6), CREBBP(68), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(9), FGF2(5), FKBP1A(1), GATA4(4), GSK3B(16), HAND1(4), HAND2(1), HRAS(4), IGF1(6), LIF(1), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MEF2C(15), MYH2(37), NFATC2(10), NFATC3(13), NFATC4(11), NPPA(1), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RPS6KB1(9), SYT1(14)	21336684	351	148	330	132	102	76	37	78	57	1	0.592	1.000	1.000
222	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	40	CD28(4), CD3D(4), CSK(3), CTLA4(4), DAG1(8), EPHB2(15), GRAP2(3), ITK(21), ITPKA(3), ITPKB(14), LAT(2), LCK(8), LCP2(9), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLCG1(17), PTPRC(27), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), SOS1(11), SOS2(15), VAV1(22), ZAP70(12)	24618596	331	148	309	116	85	77	41	70	58	0	0.477	1.000	1.000
223	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(1), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), HSD3B7(3), NSD1(25), OGDH(13), OGDHL(12), PIPOX(8), PLOD1(7), PLOD2(9), PLOD3(6), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SETD1A(20), SETD7(7), SETDB1(18), SHMT1(6), SHMT2(5), SPCS1(2), SPCS3(2), SUV39H1(4), SUV39H2(6), TMLHE(3)	28309731	331	147	312	103	115	49	33	76	58	0	0.224	1.000	1.000
224	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	20	CPEB1(7), ERBB2(28), ERBB4(56), ETS1(6), ETS2(4), ETV6(10), ETV7(3), MAPK1(3), MAPK3(3), NOTCH2(29), NOTCH3(27), NOTCH4(15), PIWIL1(27), PIWIL2(12), PIWIL3(12), PIWIL4(8), SOS1(11), SOS2(15), SPIRE1(4), SPIRE2(7)	18967813	287	146	265	90	83	52	44	67	41	0	0.230	1.000	1.000
225	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), RB1(123), RBL1(18), TFDP1(10)	8220397	237	145	188	88	41	74	20	59	35	8	0.500	1.000	1.000
226	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	45	ACCN1(13), ADCY4(14), ADCY6(13), ADCY8(30), CACNA1A(27), CACNA1B(36), GNAT3(4), GNB1(3), GNB3(6), GNG3(1), GRM4(15), ITPR3(39), KCNB1(19), PDE1A(8), PLCB2(10), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(8), SCNN1B(7), SCNN1G(9), TAS1R1(12), TAS1R2(20), TAS2R1(4), TAS2R10(6), TAS2R13(9), TAS2R14(1), TAS2R16(5), TAS2R3(5), TAS2R38(6), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(2), TAS2R43(3), TAS2R46(1), TAS2R5(2), TAS2R50(9), TAS2R60(3), TAS2R7(3), TAS2R8(8), TAS2R9(1), TRPM5(5)	25993568	391	145	379	142	141	47	43	94	65	1	0.619	1.000	1.000
227	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	46	ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(8), ACOX1(11), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP4A11(7), CYP4A22(13), DCI(3), ECHS1(3), EHHADH(13), GCDH(6), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), PECI(2)	24873648	330	144	307	97	91	61	54	82	42	0	0.0127	1.000	1.000
228	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	49	ALG2(8), BAK1(2), BTK(11), CAD(20), CASP10(7), CASP3(3), CASP8(19), CASP8AP2(27), CD7(4), CSNK1A1(3), DAXX(14), DEDD(2), DEDD2(1), DFFA(4), DIABLO(3), EPHB2(15), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(5), MAP3K1(18), MAP3K5(14), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PFN2(4), PTPN13(20), RALBP1(6), RIPK1(7), ROCK1(27), SMPD1(9), TPX2(9), TRAF2(8), TUFM(6)	30385786	377	144	347	118	92	73	42	95	69	6	0.327	1.000	1.000
229	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP12A(28), ATP4A(17), ATP4B(3), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), COX10(6), COX15(5), COX17(1), COX4I1(5), COX4I2(3), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(5), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(2), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(7), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(3), NDUFC1(1), NDUFC2(2), NDUFS1(14), NDUFS2(3), NDUFS3(4), NDUFS4(1), NDUFS5(1), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(4), PPA1(3), PPA2(3), SDHA(12), SDHB(3), SDHD(4), TCIRG1(6), UQCRB(2), UQCRC1(4), UQCRC2(11), UQCRFS1(3), UQCRH(1)	28556120	372	142	345	114	123	76	45	65	63	0	0.0288	1.000	1.000
230	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTG2(6), ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), CDC42(2), CFL1(2), CFL2(2), FLNA(24), FLNC(36), FSCN1(5), FSCN3(5), GDI1(1), GDI2(2), LIMK1(7), MYH2(37), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PFN2(4), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), VASP(4), WASF1(3), WASL(16)	22575562	347	142	319	121	98	55	42	78	69	5	0.457	1.000	1.000
231	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ENPP1(17), ENPP3(10), G6PC(4), GAA(14), GANAB(12), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), MGAM(26), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), SI(24), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UXS1(8)	30561250	340	142	324	102	97	62	43	70	67	1	0.157	1.000	1.000
232	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	57	A4GALT(6), ABO(5), B3GALNT1(5), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(3), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT6(10), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GBGT1(1), GCNT2(24), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGX(2), PIGZ(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(12), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7), UGCG(9)	23103991	312	141	286	100	98	59	24	76	54	1	0.395	1.000	1.000
233	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	28	AKT1(11), AR(20), ASAH1(4), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(8), GNA11(8), GNA15(5), GNAI1(3), GNAQ(10), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), MAPK10(14), MAPK14(7), PHKA2(15), PIK3CD(10), PITX2(2), PTX3(3), SRC(3)	18685154	298	141	289	108	101	46	39	76	36	0	0.323	1.000	1.000
234	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	42	ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AKR1B1(3), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), CEL(12), DGAT1(5), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), GK(5), GLA(7), GLB1(9), LCT(39), LIPC(5), LIPF(1), LIPG(4), LPL(12), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PPAP2A(2), PPAP2B(2), PPAP2C(3)	22925950	327	140	303	119	88	55	49	96	38	1	0.466	1.000	1.000
235	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CLDN1(1), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3)	23534840	330	140	303	133	92	57	42	69	66	4	0.815	1.000	1.000
236	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CLDN1(1), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3)	23534840	330	140	303	133	92	57	42	69	66	4	0.815	1.000	1.000
237	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	30	AKT1(11), AKT2(7), AKT3(7), ASAH1(4), DAG1(8), DRD2(7), EPHB2(15), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PI3(2), PIK3CB(5), PITX2(2), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), RGS20(9), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT3(10), TERF2IP(3)	26245453	367	140	344	119	113	58	49	87	59	1	0.223	1.000	1.000
238	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(11), BCL2(2), IGF1R(17), MYC(5), POLR2A(12), PPP2CA(3), PRKCA(5), RB1(123), TEP1(29), TERF1(5), TERT(8), TNKS(10), XRCC5(11)	12601305	241	140	189	88	53	75	23	41	41	8	0.498	1.000	1.000
239	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(23), BAD(1), BCL2(2), BCL2A1(2), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CD40(6), CD40LG(10), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), IKBKE(8), LTA(1), NFKB1(8), NFKBIA(1), NGFR(4), NR3C1(8), NTRK1(16), PTPN13(20), RIPK1(7), SFRS2IP(3), TFG(8), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10), TRAF6(4)	21653585	262	139	238	127	59	65	27	56	55	0	0.999	1.000	1.000
240	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	47	ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPS(5), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CLC(2), CPT1B(13), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), ETNK1(3), GNPAT(17), GPD1(3), GPD2(10), LCAT(4), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(6), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB2(10), PLCG1(17), PLCG2(23), PPAP2A(2), PPAP2B(2), PPAP2C(3)	24025213	317	138	295	120	102	50	47	77	41	0	0.649	1.000	1.000
241	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(6), ACSS2(9), ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), G6PC2(2), GALM(3), GAPDH(2), GAPDHS(3), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3)	28564293	344	137	317	121	112	58	36	83	55	0	0.461	1.000	1.000
242	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG5(4), ALG6(5), ALG8(12), ALG9(7), B4GALT1(7), B4GALT2(7), B4GALT3(6), DAD1(3), DDOST(4), DHDDS(4), DPAGT1(12), DPM1(3), FUT8(10), GANAB(12), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), RFT1(3), RPN1(4), RPN2(6), ST6GAL1(3), STT3B(9)	21057619	289	137	261	95	74	52	32	74	57	0	0.684	1.000	1.000
243	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), BTRC(7), CDC16(5), CDC20(3), CDC23(12), CDC26(1), CDC27(16), CUL1(16), CUL2(14), CUL3(8), FBXW11(12), FZR1(3), ITCH(7), SKP1(2), SKP2(3), SMURF1(7), SMURF2(6), TCEB2(1), UBA1(8), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D4(1), UBE2E1(4), UBE2E2(3), UBE2E3(1), VHL(83), WWP1(18), WWP2(8)	20251453	291	137	253	107	70	76	37	68	38	2	0.582	1.000	1.000
244	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(8), ACAA1(7), ACAA2(2), ACADM(9), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), AOX1(12), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(3), ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HADHB(9), HIBADH(2), HIBCH(2), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), OXCT2(3), PCCA(11), PCCB(5)	22329318	270	136	249	67	82	47	33	55	52	1	0.00879	1.000	1.000
245	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MIOX(3), OCRL(16), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CB(5), PIK3CG(36), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23)	21358953	301	135	272	101	99	53	40	66	42	1	0.389	1.000	1.000
246	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CREBBP(68), DUSP1(6), EP300(42), IKBKB(7), IL1B(4), IL8(5), MAP2K3(8), MAP2K6(4), MAP3K14(6), MAP3K7(7), MAPK14(7), MYD88(3), NFKB1(8), NFKBIA(1), NR3C1(8), RELA(9), TGFBR1(17), TGFBR2(24), TLR2(7), TNF(1)	14289776	242	135	218	96	67	69	31	44	30	1	0.688	1.000	1.000
247	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	36	BCL2(2), DAXX(14), EGF(7), ETS1(6), ETS2(4), FOS(4), HOXA7(3), HRAS(4), IKBKB(7), JUN(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK1(3), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), NFKB1(8), NFKBIA(1), PPP2CA(3), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), RELA(9), RIPK1(7), SP1(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	20885903	250	134	231	98	73	65	31	48	33	0	0.703	1.000	1.000
248	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), DBH(8), DCT(17), DDC(5), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HGD(5), HPD(6), MAOA(5), MAOB(6), PNMT(3), TAT(14), TPO(29), TYR(9)	15935467	238	134	206	82	83	45	27	56	27	0	0.201	1.000	1.000
249	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), ESCO1(16), ESCO2(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), PRDX6(4), SH3GLB1(5), TAT(14), TPO(29)	17599179	272	132	234	87	100	46	27	53	45	1	0.222	1.000	1.000
250	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(8), ACACA(30), ACACB(37), ACADM(9), ACAT1(7), ACAT2(8), ACSS1(6), ACSS2(9), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), HIBCH(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SUCLA2(6), SUCLG1(2), SUCLG2(1)	20537846	273	131	253	60	88	35	40	61	49	0	0.00183	1.000	1.000
251	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	10	AXIN1(8), CREBBP(68), EP300(42), FZD1(7), GSK3B(16), HDAC1(5), LDB1(7), LEF1(9), PITX2(2), TRRAP(61)	12453297	225	131	205	91	70	65	30	28	31	1	0.550	1.000	1.000
252	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(2), AKT1(11), ASAH1(4), CAMP(1), CAV3(3), DAG1(8), DLG4(10), EPHB2(15), GNAI1(3), GNAQ(10), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(4), RYR1(58)	19946564	288	131	281	120	118	41	40	57	31	1	0.650	1.000	1.000
253	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	65	CALR(1), CANX(5), CD4(4), CD74(3), CD8A(1), CD8B(4), CIITA(15), CREB1(3), CTSB(3), CTSL1(6), CTSS(4), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA2(4), HLA-DQB1(1), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), HSP90AA1(7), HSP90AB1(2), HSPA5(3), IFI30(3), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(9), KIR2DL4(5), KIR2DS4(4), KIR3DL1(6), KIR3DL2(6), KIR3DL3(10), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LGMN(1), LTA(1), NFYA(3), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(14), RFXANK(1), RFXAP(5), TAP1(7), TAP2(15), TAPBP(4)	20383577	292	130	273	94	51	60	39	74	57	11	0.382	1.000	1.000
254	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	41	ABP1(4), AGMAT(3), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH4A1(7), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), MAOA(5), MAOB(6), NOS1(23), NOS3(21), OAT(3), ODC1(5), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(6), RARS(7), SMS(4)	21188940	277	129	253	95	93	47	36	57	44	0	0.407	1.000	1.000
255	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(8), ASPH(12), COPS5(1), CREB1(3), EDN1(3), EP300(42), EPO(1), HIF1A(14), JUN(2), LDHA(10), NOS3(21), P4HB(6), VHL(83)	8362614	206	129	164	79	31	76	28	38	33	0	0.651	1.000	1.000
256	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(27), CDKN2A(7), MDM2(11), MYC(5), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), RAC1(2), RB1(123), TWIST1(3)	7518979	214	128	167	69	40	77	24	39	26	8	0.111	1.000	1.000
257	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ABAT(8), ADC(3), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EARS2(3), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GFPT2(11), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GNPNAT1(1), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSR(5), GSS(8), NADSYN1(4), NAGK(7), PPAT(5), QARS(13)	19930868	253	128	235	67	71	52	33	66	31	0	0.0192	1.000	1.000
258	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(6), IFNG(3), IFNGR1(6), IFNGR2(4), IKBKB(7), LIN7A(7), NFKB1(8), NFKBIA(1), RB1(123), RELA(9), TNF(1), TNFRSF1A(4), TNFRSF1B(1), USH1C(11), WT1(28)	7579512	219	128	166	77	38	80	17	44	31	9	0.407	1.000	1.000
259	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	50	ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3)	23575550	289	127	263	99	89	55	30	71	44	0	0.382	1.000	1.000
260	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	50	ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3)	23575550	289	127	263	99	89	55	30	71	44	0	0.382	1.000	1.000
261	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	39	ABP1(4), ACY3(4), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(9), ASPA(6), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(11), HARS(6), HARS2(6), HDC(8), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), PRPS2(6), UROC1(7), WBSCR22(2)	19082580	249	127	235	73	74	46	31	63	35	0	0.0724	1.000	1.000
262	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	40	ACACA(30), ACACB(37), ACAT1(7), ACAT2(8), ACOT12(8), ACSS1(6), ACSS2(9), ACYP1(1), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PCK2(6), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4)	23631024	306	127	285	98	96	49	41	67	53	0	0.261	1.000	1.000
263	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(9), AARS2(13), CARS(10), CARS2(6), DARS(4), DARS2(7), EARS2(3), EPRS(23), FARS2(5), FARSA(6), FARSB(11), GARS(8), HARS(6), HARS2(6), IARS(9), IARS2(19), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), MTFMT(1), NARS(4), NARS2(8), PARS2(2), QARS(13), RARS(7), RARS2(7), SARS(5), SARS2(4), TARS(7), TARS2(9), VARS(7), VARS2(9), WARS(3), WARS2(6), YARS(4), YARS2(6)	27433192	289	127	282	69	95	40	38	71	45	0	0.00943	1.000	1.000
264	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(5), GTF2A1L(9), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2F1(5), GTF2H1(4), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(16), TAF1(26), TAF10(1), TAF12(3), TAF13(3), TAF1L(50), TAF2(17), TAF4(9), TAF4B(9), TAF5(11), TAF5L(2), TAF6(8), TAF6L(5), TAF7(2), TAF7L(12), TAF9(2), TAF9B(1), TBPL1(3), TBPL2(2)	18564632	229	127	210	72	59	42	28	65	34	1	0.325	1.000	1.000
265	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	ANKHD1(27), EEF1A2(8), EEF1B2(1), EEF1D(9), EEF1G(1), EEF2(7), EEF2K(10), EIF1AX(1), EIF2AK2(3), EIF2AK3(13), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF4A2(10), EIF4EBP2(3), EIF4G1(17), EIF4G3(16), EIF5(6), EIF5A(2), EIF5B(20), ETF1(10), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(16), PAIP1(4), SLC35A4(3)	21475371	260	127	227	69	60	63	24	53	60	0	0.0617	1.000	1.000
266	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	34	ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), HIBADH(2), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), PCCA(11), PCCB(5), SDS(3)	17911525	240	127	220	56	68	40	32	56	43	1	0.00345	1.000	1.000
267	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	31	ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), BCR(11), CAPN1(2), CAPNS1(4), CAPNS2(4), CRKL(5), CSK(3), FYN(15), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K2(2), MAPK1(3), MAPK3(3), MAPK8(11), PTK2(24), PXN(2), RAP1A(1), ROCK1(27), SHC1(13), SOS1(11), SRC(3), TLN1(21), VCL(9), ZYX(2)	20721090	253	126	230	107	73	39	30	56	49	6	0.950	1.000	1.000
268	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ITPA(6), NME1(1), NT5C(1), NT5E(6), NT5M(3), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), RRM1(2), RRM2(5), TK1(2), TK2(2), TXNRD1(9), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UNG(3), UPB1(7), UPP1(5)	29198675	335	126	320	107	95	55	49	92	44	0	0.181	1.000	1.000
269	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(11), CREB1(3), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NFKB1(8), RB1(123), RELA(9), SP1(6)	7814192	205	125	158	62	38	68	19	45	27	8	0.101	1.000	1.000
270	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1D1(8), ARSD(9), ARSE(4), CARM1(3), CYP11B1(13), CYP11B2(7), CYP19A1(8), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), WBSCR22(2)	24618252	289	125	277	92	77	50	35	69	58	0	0.241	1.000	1.000
271	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	13	BCL2(2), CREBBP(68), EP300(42), FYN(15), IL2RG(8), IL7(3), IL7R(12), JAK1(20), JAK3(27), LCK(8), NMI(3), PTK2B(13), STAT5A(8)	11749252	229	125	199	85	57	68	23	41	40	0	0.618	1.000	1.000
272	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	28	ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), DRD1(9), DRD2(7), DRD3(5), DRD5(10), HRH1(4), HRH2(15), HTR1A(15), HTR1B(11), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12)	11355954	238	125	218	88	101	41	32	37	27	0	0.179	1.000	1.000
273	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CDK5(2), CDK5R1(5), CFL1(2), CHN1(5), LIMK1(7), MAP3K1(18), MYL2(2), MYLK(29), NCF2(8), PAK1(10), PDGFRA(56), PLD1(16), RAC1(2), RALBP1(6), RPS6KB1(9), TRIO(38), VAV1(22), WASF1(3)	15118148	242	125	227	87	60	56	33	55	34	4	0.452	1.000	1.000
274	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	28	ACTR2(1), ACTR3(4), ARHGAP1(3), ARHGAP4(7), ARHGAP6(10), ARHGEF1(13), ARHGEF11(20), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), BAIAP2(6), CFL1(2), DIAPH1(7), GSN(4), LIMK1(7), MYL2(2), MYLK(29), OPHN1(7), PIP5K1A(7), PIP5K1B(3), ROCK1(27), SRC(3), TLN1(21), VCL(9)	21257075	220	125	203	81	70	30	24	51	40	5	0.828	1.000	1.000
275	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	34	CALM2(1), CALM3(1), CD3D(4), CD3E(2), ELK1(4), FOS(4), FYN(15), HRAS(4), JUN(2), LAT(2), LCK(8), MAP3K1(18), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), PTPN7(3), RAC1(2), RASA1(20), RELA(9), SHC1(13), SOS1(11), SYT1(14), VAV1(22), ZAP70(12)	19886463	268	125	241	94	85	56	24	43	59	1	0.538	1.000	1.000
276	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	38	APAF1(23), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), FADD(1), FAS(7), FASLG(3), GZMB(4), IKBKG(2), JUN(2), MAP3K1(18), MAP3K14(6), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), PARP1(16), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(2), TRAF1(5), TRAF2(8)	17722890	229	124	208	74	55	49	29	44	52	0	0.312	1.000	1.000
277	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	43	AACS(7), AADAC(5), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ACSM1(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH7A1(6), ALDH9A1(4), BDH1(3), BDH2(2), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADH(2), HADHA(10), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), HSD3B7(3), ILVBL(8), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(7), PDHA2(14), PDHB(3), PLA1A(8), PPME1(2), PRDX6(4), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	19941452	262	124	242	79	87	47	31	64	33	0	0.0510	1.000	1.000
278	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	34	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCR(11), BLNK(1), BTK(11), CD19(10), CSK(3), DAG1(8), EPHB2(15), ITPKA(3), ITPKB(14), LYN(13), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PI3(2), PIK3CD(10), PLCG2(23), PPP1R13B(9), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22)	22232517	263	124	246	76	93	43	35	56	35	1	0.0278	1.000	1.000
279	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(11), ATF1(5), CDC42(2), CREB1(3), CREB3(5), CREB5(5), DUSP1(6), DUSP10(5), EEF2K(10), ELK1(4), IL1R1(6), MAP2K3(8), MAP2K6(4), MAP3K10(10), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MKNK1(2), MKNK2(6), MYEF2(14), NFKB1(8), NR2C2(11), SRF(4), TRAF6(4)	16458665	231	124	205	59	60	41	35	48	46	1	0.0199	1.000	1.000
280	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), HRAS(4), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(10), RAC1(2), RB1(123), RELA(9), TFDP1(10)	7730754	209	123	160	74	36	70	21	44	30	8	0.455	1.000	1.000
281	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(4), AKT1(11), AKT2(7), AKT3(7), DAG1(8), GNAQ(10), IKBKG(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PIK3CB(5), PITX2(2), PLD1(16), PLD2(7), PLD3(7), VN1R1(7)	21502783	273	123	263	93	87	55	38	57	36	0	0.276	1.000	1.000
282	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(8), F12(5), F13B(10), F2(9), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), LPA(28), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8), SERPINF2(4), VWF(30)	18220608	283	122	259	109	68	53	42	72	45	3	0.740	1.000	1.000
283	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	ALOX12(3), ALOX12B(4), ALOX15(4), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP2U1(5), CYP4A11(7), CYP4A22(13), CYP4F2(12), CYP4F3(10), DHRS4(1), EPHX2(5), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11)	19659459	241	122	227	84	76	37	35	63	30	0	0.424	1.000	1.000
284	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), DAG1(8), DGKA(8), ETFA(4), GCA(1), ITGA9(9), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(10), PDE3A(19), PDE3B(8), PI3(2), PIK3C2G(19), PIK3CD(10), PLDN(1), PSME1(1), RIPK3(5), RPS4X(1), SGCB(3), VASP(4)	21788080	289	122	280	107	85	50	35	71	47	1	0.646	1.000	1.000
285	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	25	ACVR1(6), ATF2(6), AXIN1(8), BMP10(13), BMP2(8), BMP4(5), BMP5(8), BMP7(14), CHRD(14), FZD1(7), GATA4(4), GSK3B(16), MAP3K7(7), MEF2C(15), MYL2(2), NPPA(1), NPPB(4), RFC1(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14)	12012447	223	121	206	77	83	37	25	48	29	1	0.284	1.000	1.000
286	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	24	DPM2(1), ELK1(4), GNB1(3), HRAS(4), IGF1R(17), ITGB1(12), KLK2(4), MAP2K2(2), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MYC(5), NGFR(4), PDGFRA(56), PPP2CA(3), PTPRR(11), RPS6KA1(9), RPS6KA5(10), SHC1(13), SOS1(11), SRC(3), STAT3(10)	13278982	196	120	177	80	48	49	27	38	31	3	0.790	1.000	1.000
287	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(8), AGXT2(8), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), ATP6V0C(1), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CPT1B(13), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), MAOA(5), MAOB(6), PEMT(2), PISD(5), PLCB2(10), PLCG1(17), PLCG2(23), PSPH(1), SARDH(15), SARS(5), SHMT1(6), SHMT2(5), TARS(7)	21297265	264	120	242	97	95	39	35	51	44	0	0.604	1.000	1.000
288	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(9), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(5), ADSSL1(6), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), ASRGL1(1), ASS1(4), CAD(20), CRAT(10), DARS(4), DARS2(7), DDO(6), DLAT(7), DLD(3), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), NARS2(8), PC(12), PDHA1(7), PDHA2(14), PDHB(3)	19177377	244	120	230	87	81	36	37	53	37	0	0.465	1.000	1.000
289	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(28), ATP4B(3), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ATP7A(11), ATP7B(14), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3), PPA2(3), SDHA(12), SDHB(3), SHMT1(6), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1)	19721532	243	120	225	83	80	43	32	45	43	0	0.232	1.000	1.000
290	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(11), AKT2(7), AKT3(7), ARHGEF11(20), BCL2(2), CDC42(2), DLG4(10), GNA13(3), IKBKG(2), LPA(28), MAP3K1(18), MAP3K5(14), MAPK8(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PI3(2), PIK3CB(5), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RDX(13), ROCK1(27), ROCK2(15), SERPINA4(5), SRF(4)	24295795	302	120	279	94	88	48	30	74	57	5	0.399	1.000	1.000
291	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	29	BTK(11), CALM2(1), CALM3(1), ELK1(4), FCER1A(5), FOS(4), HRAS(4), JUN(2), LYN(13), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PAK2(14), PLA2G4A(13), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22)	17416511	241	119	221	71	66	53	28	49	44	1	0.151	1.000	1.000
292	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(26), GABBR1(16), GPRC5A(5), GPRC5B(3), GPRC5C(9), GPRC5D(3), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM7(30), GRM8(27)	10083260	224	119	193	88	92	30	27	44	31	0	0.620	1.000	1.000
293	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	30	BLNK(1), BTK(11), CALM2(1), CALM3(1), CD79A(6), CD79B(2), ELK1(4), FOS(4), HRAS(4), JUN(2), LYN(13), MAP3K1(18), MAPK14(7), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), RAC1(2), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22)	17605417	229	118	211	78	68	47	27	45	41	1	0.457	1.000	1.000
294	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	32	AGT(10), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDK5(2), F2(9), FYN(15), GNA11(8), GNAI1(3), GNB1(3), HRAS(4), MAP2K2(2), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MAPT(10), MYLK(29), PLCG1(17), PRKCA(5), PTK2B(13), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), SYT1(14)	18586413	253	118	228	99	64	46	34	55	53	1	0.839	1.000	1.000
295	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	25	ABAT(8), ABP1(4), ACADL(4), ACADM(9), ACADSB(7), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), MLYCD(4), SDS(3), SMS(4), UPB1(7)	13985050	234	117	219	60	71	31	35	68	29	0	0.00611	1.000	1.000
296	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(8), AGXT2(8), AKR1B10(3), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), GNMT(3), HSD3B7(3), MAOA(5), MAOB(6), PEMT(2), PHGDH(3), PIPOX(8), PISD(5), PSAT1(6), PSPH(1), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SARDH(15), SARS(5), SARS2(4), SDS(3), SHMT1(6), SHMT2(5), TARS(7), TARS2(9)	22029091	256	117	241	90	89	35	35	58	39	0	0.446	1.000	1.000
297	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(16), CCNE1(6), CDC34(2), CDK2(5), CUL1(16), RB1(123), SKP2(3), TFDP1(10)	4612671	181	117	133	64	31	63	10	43	26	8	0.387	1.000	1.000
298	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(3), B4GALT1(7), B4GALT2(7), G6PC(4), G6PC2(2), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANC(8), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), HSD3B7(3), LALBA(1), LCT(39), MGAM(26), PFKL(7), PFKM(2), PFKP(15), PGM1(8), PGM3(5), RDH11(3), RDH12(6), RDH13(4), RDH14(1), UGP2(10)	18749746	246	116	235	87	87	40	30	61	28	0	0.343	1.000	1.000
299	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	10	CREBBP(68), EP300(42), MAP3K7(7), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24)	9225487	178	116	156	79	55	53	21	25	24	0	0.860	1.000	1.000
300	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	39	CDC6(6), CDK2(5), DIAPH2(24), GMNN(3), MCM10(10), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), PRIM1(5), RFC1(20), RFC2(2), RFC4(8), RFC5(6), RPA1(12), RPA2(1), RPA4(5), UBA52(3), UBB(2), UBC(6)	24800410	270	115	247	89	56	51	35	70	57	1	0.496	1.000	1.000
301	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), PON1(11)	14763894	222	115	217	66	85	37	21	53	25	1	0.0786	1.000	1.000
302	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(8), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSS(8), NADSYN1(4), PPAT(5), QARS(13)	17216991	223	115	205	54	58	49	29	61	26	0	0.00919	1.000	1.000
303	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	35	ATF2(6), CDC42(2), CREB1(3), DAXX(14), DDIT3(4), ELK1(4), HRAS(4), HSPB2(2), MAP2K6(4), MAP3K1(18), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MYC(5), PLA2G4A(13), RAC1(2), RIPK1(7), RPS6KA5(10), SHC1(13), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8)	18046677	238	115	222	74	76	47	26	47	41	1	0.302	1.000	1.000
304	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	20	CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), JAK1(20), JUN(2), MAP3K1(18), MAPK3(3), MAPK8(11), PDGFA(2), PDGFRA(56), PLCG1(17), PRKCA(5), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8)	14396620	234	115	210	81	56	51	25	54	45	3	0.671	1.000	1.000
305	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(5), CDKN1B(4), CKS1B(2), CUL1(16), RB1(123), SKP2(3), TFDP1(10), UBE2M(2)	4522685	171	114	125	60	26	61	10	37	29	8	0.473	1.000	1.000
306	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	21	ATF2(6), BCR(11), BLNK(1), ELK1(4), FOS(4), HRAS(4), JUN(2), LYN(13), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8IP3(11), PAPPA(33), RAC1(2), RPS6KA1(9), RPS6KA3(13), SHC1(13), SOS1(11), SYK(5), VAV1(22), VAV3(27)	14252438	215	114	198	56	66	43	28	48	29	1	0.0218	1.000	1.000
307	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	18	ADCY1(22), CD3D(4), CD3E(2), CD4(4), CREBBP(68), CSK(3), GNB1(3), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12)	10162075	184	113	169	75	51	53	20	30	28	2	0.696	1.000	1.000
308	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	18	ADCY1(22), CD3D(4), CD3E(2), CD4(4), CREBBP(68), CSK(3), GNB1(3), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12)	10162075	184	113	169	75	51	53	20	30	28	2	0.696	1.000	1.000
309	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	33	CALM2(1), CALM3(1), CAMK1G(5), ELK1(4), FPR1(5), GNA15(5), GNB1(3), HRAS(4), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NCF1(4), NCF2(8), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PAK1(10), PIK3C2G(19), PLCB1(22), PPP3CA(3), PPP3CB(10), PPP3CC(5), RAC1(2), RELA(9), SYT1(14)	17347368	222	113	210	82	67	42	25	52	35	1	0.601	1.000	1.000
310	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	29	ABAT(8), ACACA(30), ACADL(4), ACADM(9), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), LDHA(10), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SDS(3), SUCLA2(6), SUCLG1(2), SUCLG2(1)	16495616	227	113	207	51	68	32	33	52	42	0	0.00872	1.000	1.000
311	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	34	ACACA(30), ACAT1(7), ACAT2(8), ACYP1(1), ADH5(6), AKR1B1(3), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4)	17789126	240	113	218	82	69	45	31	55	40	0	0.458	1.000	1.000
312	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	21	AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), GSK3A(6), GSK3B(16), IL4R(6), IRS1(17), JAK1(20), JAK3(27), MAP4K1(6), MAPK1(3), MAPK3(3), PDK1(5), PIK3CD(10), PPP1R13B(9), SHC1(13), SOS1(11), SOS2(15), STAT6(4)	14695928	199	113	175	55	57	43	21	38	39	1	0.130	1.000	1.000
313	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(6), ELK1(4), FOS(4), IKBKB(7), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), PPARA(7), RELA(9), TIRAP(5), TLR10(11), TLR2(7), TLR3(13), TLR4(15), TLR6(12), TLR7(15), TLR9(12), TOLLIP(5), TRAF6(4)	17411286	223	113	218	65	57	40	23	60	42	1	0.199	1.000	1.000
314	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	18	AXIN1(8), BTRC(7), CCND1(2), CREBBP(68), CSNK1A1(3), CSNK1D(14), CSNK2A1(7), CTBP1(5), FZD1(7), GSK3B(16), HDAC1(5), MAP3K7(7), MYC(5), NLK(12), PPARD(4), PPP2CA(3), TLE1(7), WIF1(5)	10164911	185	113	171	75	50	40	32	33	29	1	0.674	1.000	1.000
315	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(22), AKT1(11), ASAH1(4), GNAI1(3), GNB1(3), ITGB3(12), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(56), PLCB1(22), PRKCA(5), PTK2(24), RAC1(2), SMPD1(9), SMPD2(3), SPHK1(2), SRC(3)	11023088	189	112	168	80	49	51	27	42	18	2	0.800	1.000	1.000
316	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(7), B4GALT2(7), FBP2(4), G6PC(4), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANAB(12), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), LALBA(1), LCT(39), MGAM(26), PFKM(2), PFKP(15), PGM1(8), PGM3(5)	15965997	215	112	207	80	74	40	26	50	25	0	0.538	1.000	1.000
317	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	24	ABAT(8), ABP1(4), ACADM(9), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), HIBCH(2), MLYCD(4), SMS(4), SRM(1), UPB1(7)	13395242	218	112	203	60	68	30	32	61	27	0	0.0258	1.000	1.000
318	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(11), ALAS2(10), BLVRA(2), BLVRB(1), COX10(6), COX15(5), CP(18), CPOX(3), EARS2(3), EPRS(23), FECH(3), FTH1(1), FTMT(7), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), MMAB(1), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UROD(2), UROS(5)	21277127	250	112	225	63	57	47	32	62	52	0	0.0881	1.000	1.000
319	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(9), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CYP2C19(11), CYP2C9(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), HADHA(10), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3)	15312600	226	112	204	71	62	46	28	52	37	1	0.290	1.000	1.000
320	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ACTG1(6), ACTG2(6), ADCY3(10), ADCY9(19), AK1(1), ARF1(1), ARF4(4), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ERO1L(3), PDIA4(7), PLCG1(17), PLCG2(23), PRKCA(5), SEC61A1(9), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(13)	18091256	227	112	199	89	76	53	26	38	34	0	0.658	1.000	1.000
321	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	AGT(10), AGTR1(12), ATF2(6), CALM2(1), CALM3(1), ELK1(4), GNAQ(10), HRAS(4), JUN(2), MAP2K2(2), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), MEF2A(5), MEF2C(15), MEF2D(3), PAK1(10), PRKCA(5), PTK2(24), PTK2B(13), RAC1(2), SHC1(13), SOS1(11), SRC(3), SYT1(14)	14339906	205	111	188	77	43	42	20	55	44	1	0.866	1.000	1.000
322	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(3), CREBBP(68), EP300(42), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RARA(5), RXRA(8)	10639166	168	111	157	77	41	45	25	30	27	0	0.927	1.000	1.000
323	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	30	ADCY1(22), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(4), GNAI1(3), GNAQ(10), GNB1(3), HRAS(4), JUN(2), MAPK3(3), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RPS6KA3(13), SYT1(14)	14772134	186	111	169	77	62	50	16	30	28	0	0.736	1.000	1.000
324	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	29	AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ATP6V0C(1), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADHA(10), PLOD1(7), PLOD2(9), PLOD3(6), SDS(3), SHMT1(6), SHMT2(5), TMLHE(3)	16807258	210	111	197	57	62	34	26	52	36	0	0.0316	1.000	1.000
325	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TAT(14), TPO(29)	11185665	183	111	157	49	78	27	18	33	27	0	0.0250	1.000	1.000
326	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), P4HB(6), SLC23A1(9), SLC23A2(17), SLC2A1(5), SLC2A3(12)	13422700	182	111	171	65	45	24	27	48	38	0	0.144	1.000	1.000
327	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	36	ACAA1(7), ACAA2(2), ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1B10(3), AKR1D1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), HSD3B7(3), LIPA(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SLC27A5(7), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2)	15485581	209	110	194	59	55	39	33	56	25	1	0.0444	1.000	1.000
328	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	26	ATF1(5), BAD(1), CREB1(3), CREB3(5), CREB5(5), DUSP4(6), DUSP6(6), DUSP9(9), EEF2K(10), MAP2K2(2), MAP3K8(4), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MOS(8), NFKB1(8), RAP1A(1), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), SHC1(13), SOS1(11), SOS2(15), TRAF3(10)	13838529	180	110	164	63	50	37	23	31	38	1	0.461	1.000	1.000
329	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	24	AKT1(11), CABIN1(22), CALM2(1), CALM3(1), CAMK1G(5), HDAC5(13), IGF1(6), IGF1R(17), INSR(20), MAP2K6(4), MAPK14(7), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NFATC2(10), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYT1(14), YWHAH(3)	13933159	181	109	171	75	58	41	21	38	23	0	0.688	1.000	1.000
330	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), NOS1(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), SYT1(14)	12815583	197	109	183	90	67	40	15	42	33	0	0.935	1.000	1.000
331	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(6), CDC34(2), CDK2(5), CUL1(16), RB1(123), TFDP1(10)	3556469	162	108	116	55	25	59	9	36	25	8	0.326	1.000	1.000
332	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	23	AKT1(11), AKT2(7), AKT3(7), CISH(2), IARS(9), IL13RA1(5), IL2RG(8), IL4(5), IL4R(6), INPP5D(8), JAK1(20), JAK3(27), PI3(2), PPP1R13B(9), RPS6KB1(9), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT6(4), TYK2(5)	15995435	191	108	172	59	51	33	22	41	43	1	0.417	1.000	1.000
333	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	24	AKT1(11), AKT2(7), AKT3(7), ANKRD6(12), AXIN1(8), CER1(4), CSNK1A1(3), DACT1(18), DKK1(8), DKK3(7), DKK4(5), FSTL1(9), GSK3A(6), GSK3B(16), LRP1(49), MVP(10), NKD1(6), PIN1(2), PSEN1(3), PTPRA(5), SENP2(3), SFRP1(2), TSHB(1), WIF1(5)	14677218	207	108	197	76	78	35	22	38	33	1	0.563	1.000	1.000
334	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(12), AGT(10), AGTR1(12), CMA1(1), COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), REN(8)	13166602	176	107	171	58	41	26	25	47	37	0	0.0952	1.000	1.000
335	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	25	AACS(7), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH9A1(4), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), L2HGDH(3), OXCT1(3), PDHA1(7), PDHA2(14), PDHB(3), SDHB(3), SDS(3)	12441010	191	107	174	51	56	33	26	50	26	0	0.0229	1.000	1.000
336	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	17	DIAPH1(7), FYN(15), GSN(4), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PTK2(24), PXN(2), ROCK1(27), SHC1(13), SRC(3), TLN1(21)	15064381	181	107	156	65	42	27	26	38	42	6	0.743	1.000	1.000
337	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GAPDHS(3), GCK(3), GOT1(6), GOT2(2), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6B(6), LDHB(5), LDHC(4), MDH1(8), MDH2(3), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PKLR(11), PKM2(4), TNFAIP1(4), TPI1(3)	20765388	233	107	217	98	91	38	23	47	34	0	0.857	1.000	1.000
338	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(10), POLA2(5), POLB(4), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLG(8), POLG2(4), POLH(13), POLK(9), POLM(11), POLQ(37), PRIM1(5), PRIM2(2), REV1(13), REV3L(36), RFC5(6)	21027386	240	107	220	77	54	38	32	65	50	1	0.582	1.000	1.000
339	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(4), ACY1(5), ADC(3), AGMAT(3), ALDH18A1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), ASS1(4), CPS1(31), GATM(2), MAOA(5), MAOB(6), NAGS(5), ODC1(5), OTC(14), SAT1(4), SAT2(1), SMS(4), SRM(1)	14757811	192	106	173	60	58	41	25	45	23	0	0.181	1.000	1.000
340	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(23), C5(20), C6(24), C7(10), ICAM1(4), IL1A(1), IL6(5), IL8(5), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELP(13), TNF(1), VCAM1(12)	12311973	178	106	170	62	58	27	20	38	34	1	0.336	1.000	1.000
341	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(68), EP300(42), LPL(12), NCOA1(13), NCOA2(21), PPARG(4), RXRA(8)	9283947	168	106	157	77	40	47	27	32	22	0	0.910	1.000	1.000
342	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CREBBP(68), EP300(42), FADD(1), HDAC3(3), IKBKB(7), IKBKG(2), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	10714589	158	106	146	69	43	46	20	24	25	0	0.852	1.000	1.000
343	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), DAG1(8), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFAT5(6), PDE6A(12), PDE6B(11), PDE6C(10), PDE6D(2), SLC6A13(9), TF(16)	17658234	238	106	234	84	75	43	28	51	41	0	0.328	1.000	1.000
344	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYB(2), NFYC(10), RB1(123), SP1(6), SP3(10)	3561443	154	106	109	50	18	64	10	34	20	8	0.114	1.000	1.000
345	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(2), ENPP7(2), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(5), SGMS2(6), SGPP1(6), SGPP2(4), SMPD1(9), SMPD2(3), SMPD3(4), SMPD4(8), SPHK1(2), SPHK2(5), SPTLC1(11), SPTLC2(9), UGCG(9), UGT8(10)	16365010	211	105	203	73	62	36	32	49	32	0	0.286	1.000	1.000
346	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(23), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CYCS(1), DFFA(4), DFFB(2), FADD(1), GAS2(4), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), SPTAN1(25), TNFRSF10A(8), TNFRSF10B(4), TNFRSF25(2), TNFSF10(2), TNFSF12(2), TRAF2(8)	16231836	178	103	161	67	38	38	22	42	37	1	0.811	1.000	1.000
347	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(7), ACAT2(8), ACOT11(9), ACYP1(1), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), FN3K(1), GCDH(6), HADHA(10), ITGB1BP3(1), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3)	13158598	178	103	161	60	47	35	23	38	34	1	0.477	1.000	1.000
348	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(5), ARSB(10), FUCA1(5), FUCA2(4), GALNS(6), GBA(4), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NAGLU(5), NEU1(6), NEU2(6), NEU3(2), SPAM1(9)	16510767	213	103	202	70	65	52	20	52	24	0	0.229	1.000	1.000
349	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	16	CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), INSR(20), IRS1(17), JUN(2), MAPK3(3), MAPK8(11), PTPN11(31), RASA1(20), SHC1(13), SLC2A4(7), SOS1(11), SRF(4)	9469933	158	103	135	57	38	37	21	34	27	1	0.633	1.000	1.000
350	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(68), EP300(42), ESR1(20), MAPK1(3), MAPK3(3), PELP1(11), SRC(3)	7678049	150	103	140	68	40	38	19	29	24	0	0.920	1.000	1.000
351	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(12), EPHA4(20), EPHB1(33), FYN(15), ITGA1(12), ITGB1(12), L1CAM(14), LYN(13), RAP1B(2), SELP(13)	7982869	146	102	134	47	44	31	27	28	15	1	0.0971	1.000	1.000
352	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(8), CALCRL(7), CD97(10), CRHR1(4), CRHR2(5), ELTD1(11), EMR1(13), EMR2(7), GHRHR(2), GIPR(1), GLP1R(6), GLP2R(8), GPR64(17), LPHN1(19), LPHN2(26), LPHN3(26), SCTR(5), VIPR1(6), VIPR2(11)	13892229	196	102	192	84	61	31	19	60	25	0	0.849	1.000	1.000
353	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(12), ACO1(11), ACO2(7), CLYBL(6), CS(2), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), OGDHL(12), PC(12), PCK1(3), PCK2(6), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1)	14983809	160	102	151	54	55	22	26	35	22	0	0.274	1.000	1.000
354	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(7), ARG1(2), ARG2(5), ASL(3), ASS1(4), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), EPRS(23), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), LAP3(3), NOS1(23), NOS3(21), OAT(3), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(5), RARS(7), RARS2(7)	17466364	206	102	190	68	66	31	33	43	33	0	0.356	1.000	1.000
355	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	16	CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), IL6(5), IL6R(7), IL6ST(14), JAK1(20), JAK3(27), JUN(2), MAPK3(3), PTPN11(31), SHC1(13), SOS1(11), SRF(4), STAT3(10)	9510024	166	102	130	49	37	43	23	31	31	1	0.248	1.000	1.000
356	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	ALOX12(3), ALOX15(4), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(10), EPX(13), LPO(9), LTA4H(2), MPO(13), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11), TPO(29)	13695641	186	102	175	63	78	27	23	36	22	0	0.234	1.000	1.000
357	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(4), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GCNT1(7), GCNT3(4), GCNT4(12), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(5)	16246956	208	101	200	88	66	30	29	52	31	0	0.960	1.000	1.000
358	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(12), CAPN1(2), CAPN2(8), CAPNS1(4), CAPNS2(4), CXCR3(4), EGF(7), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTK2(24), PXN(2), TLN1(21)	15734647	178	101	173	69	48	38	29	37	25	1	0.560	1.000	1.000
359	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(9), ABAT(8), ADSL(13), ADSS(5), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), CAD(20), CRAT(10), DARS(4), DDO(6), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), PC(12)	13176927	167	100	155	58	55	22	26	41	23	0	0.425	1.000	1.000
360	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(12), ACE2(12), AGT(10), AGTR1(12), ANPEP(16), CMA1(1), CPA3(4), CTSA(6), CTSG(4), ENPEP(22), LNPEP(21), MAS1(2), MME(23), NLN(10), REN(8), THOP1(6)	10428646	169	100	156	44	37	33	24	42	33	0	0.0452	1.000	1.000
361	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(10), ADRBK2(8), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CLCA1(12), CLCA2(8), CLCA4(14), CNGA3(14), CNGA4(13), CNGB1(15), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(2), PDC(4), PDE1C(17), PRKACA(1), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(10), PRKX(3)	16096741	196	100	190	91	56	30	28	50	32	0	0.960	1.000	1.000
362	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(11), BAIAP2(6), CASP1(6), CASP3(3), CASP7(3), CASP8(19), GAPDH(2), INSR(20), ITCH(7), MAGI1(27), MAGI2(25), RERE(15), WWP1(18), WWP2(8)	12050699	170	100	158	64	47	26	27	35	34	1	0.700	1.000	1.000
363	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	IFNA1(7), IFNB1(6), IKBKB(7), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL1RN(6), IL6(5), IRAK1(6), IRAK2(11), IRAK3(9), JUN(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1), TOLLIP(5), TRAF6(4)	14135638	177	100	170	54	58	26	21	46	26	0	0.219	1.000	1.000
364	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	25	CALM2(1), CALM3(1), EGR2(14), EGR3(6), GNAQ(10), MAP3K1(18), MYC(5), NFATC2(10), NFKB1(8), NFKBIA(1), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), SYT1(14), VIP(3), VIPR2(11)	12624877	171	100	159	59	49	37	22	32	31	0	0.356	1.000	1.000
365	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(3), AKR1B10(3), ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), FUK(9), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), HSD3B7(3), KHK(4), LHPP(5), MPI(4), MTMR1(12), MTMR2(7), MTMR6(9), PFKFB1(12), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(7), PFKM(2), PFKP(15), PGM2(3), PHPT1(2), PMM1(3), PMM2(2), RDH11(3), RDH12(6), RDH13(4), RDH14(1), TPI1(3), TSTA3(1)	18393853	200	99	189	82	81	29	22	38	30	0	0.759	1.000	1.000
366	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	15	CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), IGF1(6), IGF1R(17), IRS1(17), JUN(2), MAPK3(3), MAPK8(11), PTPN11(31), RASA1(20), SHC1(13), SOS1(11), SRF(4)	9113019	154	99	132	52	39	34	17	32	31	1	0.536	1.000	1.000
367	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BIRC2(5), BIRC3(11), CASP3(3), CASP8(19), CFLAR(2), FADD(1), IKBKG(2), JUN(2), MAP3K3(6), MAP3K7(7), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NR2C2(11), RALBP1(6), RIPK1(7), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	12201962	157	99	138	50	34	45	13	30	35	0	0.348	1.000	1.000
368	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	24	ACAA1(7), ACAA2(2), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AKR1D1(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), SOAT2(4), SRD5A1(2), SRD5A2(2)	10636745	163	98	150	37	39	32	25	45	21	1	0.00569	1.000	1.000
369	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(2), DLAT(7), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), PC(12), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PDK1(5), PDK2(8), PDK3(5), PDK4(4), PDP2(5), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1)	14714864	171	98	157	65	55	28	26	36	26	0	0.566	1.000	1.000
370	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	26	DUSP1(6), IKBKG(2), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PIK3CD(10), SYT1(14), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4)	11815772	165	98	147	51	51	40	18	34	22	0	0.161	1.000	1.000
371	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(12), ITGB3(12), PTK2(24), PXN(2), RAC1(2), SPTAN1(25), SRC(3), TLN1(21)	14529895	165	98	159	88	52	30	19	40	22	2	0.998	1.000	1.000
372	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(4), CSF1R(15), DDX20(6), E2F4(2), ETS1(6), ETS2(4), ETV3(4), FOS(4), HDAC2(8), HDAC5(13), HRAS(4), JUN(2), NCOR2(38), RBL1(18), RBL2(22), SIN3A(20), SIN3B(9)	12922974	179	97	160	69	46	33	17	35	48	0	0.892	1.000	1.000
373	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(7), CDK7(3), ERCC3(18), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2H1(4), GTF2H4(3), ILK(3), MNAT1(3), POLR1A(12), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3B(8), POLR3D(5), POLR3E(10), POLR3H(2), POLR3K(1), TAF12(3), TAF13(3), TAF5(11), TAF6(8), TAF7(2), TAF9(2), TBP(2)	17969059	172	97	163	72	41	33	26	40	32	0	0.937	1.000	1.000
374	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	19	BTK(11), DLG4(10), EPHB2(15), F2(9), F2RL2(6), JUN(2), MAP2K5(4), MAPK1(3), MAPK7(6), MAPK8(11), MYEF2(14), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RASAL1(7), SRC(3), TEC(8), VAV1(22)	12980325	185	97	179	71	62	38	24	38	23	0	0.656	1.000	1.000
375	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C8B(22), C9(11), MASP1(19)	12608648	173	96	161	59	50	22	21	39	39	2	0.662	1.000	1.000
376	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5)	12636124	170	95	152	66	38	41	23	42	25	1	0.747	1.000	1.000
377	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(22), CALM2(1), CALM3(1), CAPN2(8), CAPNS1(4), CAPNS2(4), EP300(42), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(10), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SYT1(14)	11515991	145	95	132	65	39	31	21	26	28	0	0.911	1.000	1.000
378	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	35	ARNTL(11), AZIN1(3), BTG1(2), CBX3(6), CRY2(5), DNAJA1(4), EIF4G2(16), ETV6(10), GFRA1(12), GSTM3(5), GSTP1(1), HERPUD1(3), HSPA8(11), IDI1(4), KLF9(1), MYF6(6), NCKAP1(15), NCOA4(8), NR1D2(7), PER1(12), PER2(7), PIGF(1), PPP1R3C(4), PPP2CB(2), PSMA4(3), SF3A3(1), SUMO3(1), TUBB3(8), UCP3(3), UGP2(10), VAPA(2), ZFR(15)	16857784	199	94	180	61	64	28	20	45	41	1	0.392	1.000	1.000
379	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	26	AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CFLAR(2), CRKL(5), FOS(4), HRAS(4), IL2RA(3), IL2RB(4), IL2RG(8), IRS1(17), JAK1(20), JAK3(27), MAPK1(3), MAPK3(3), MYC(5), NMI(3), PPIA(1), PTPN6(4), RPS6KB1(9), SHC1(13), SOS1(11), STAT5A(8), SYK(5)	13111401	174	94	150	54	46	31	26	31	39	1	0.356	1.000	1.000
380	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	24	BCAR1(5), CALM2(1), CALM3(1), CRKL(5), GNAQ(10), HRAS(4), JUN(2), MAP2K2(2), MAP2K3(8), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), PAK1(10), PLCG1(17), PRKCA(5), PTK2B(13), RAC1(2), SHC1(13), SOS1(11), SRC(3), SYT1(14)	12545922	168	94	153	67	36	34	17	49	31	1	0.940	1.000	1.000
381	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(23), ARHGDIB(5), BIRC2(5), BIRC3(11), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), GZMB(4), LMNB1(9), LMNB2(2), PRF1(7)	9933116	134	93	116	51	24	32	11	36	31	0	0.902	1.000	1.000
382	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(5), DAB1(13), FYN(15), LRP8(1), RELN(83), VLDLR(13)	7325732	132	93	109	41	35	35	16	27	19	0	0.0713	1.000	1.000
383	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(66), MAP2(51), PPP1CA(2), PPP2CA(3), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4), PRKCE(4)	9497583	149	92	132	48	30	33	20	33	33	0	0.402	1.000	1.000
384	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	FADD(1), IKBKB(7), IKBKG(2), IL1A(1), IL1R1(6), IRAK1(6), MAP3K1(18), MAP3K14(6), MAP3K7(7), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TLR4(15), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	11340662	146	92	138	51	34	40	16	31	25	0	0.449	1.000	1.000
385	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(39), APOA1(3), APOA4(4), APOC2(1), APOE(1), CETP(11), CYP7A1(13), DGAT1(5), HMGCR(6), LCAT(4), LDLR(9), LIPC(5), LPL(12), LRP1(49), SCARB1(3), SOAT1(6)	13528722	171	92	161	64	55	29	23	43	21	0	0.571	1.000	1.000
386	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(9), CARS(10), DARS(4), EPRS(23), FARS2(5), GARS(8), HARS(6), IARS(9), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), NARS(4), QARS(13), RARS(7), SARS(5), TARS(7), WARS(3), WARS2(6), YARS(4)	17070398	165	91	160	36	54	23	25	40	23	0	0.0126	1.000	1.000
387	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	19	CSNK2A1(7), EGF(7), ELK1(4), FOS(4), HRAS(4), JAK1(20), JUN(2), MAP3K1(18), MAPK3(3), MAPK8(11), PLCG1(17), PRKCA(5), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8)	14375051	183	91	168	62	50	31	18	42	41	1	0.739	1.000	1.000
388	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(10), CHIT1(10), CMAS(6), CTBS(6), CYB5R1(2), CYB5R3(1), GFPT1(5), GFPT2(11), GNE(7), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NAGK(7), NANS(1), NPL(3), PGM3(5), PHPT1(2), RENBP(3), UAP1(6)	14792435	170	91	164	47	61	33	19	32	25	0	0.0594	1.000	1.000
389	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(13), GLI2(22), GLI3(37), GSK3B(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SHH(3), SMO(11), SUFU(5)	7885736	140	91	129	62	54	30	13	21	22	0	0.725	1.000	1.000
390	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), LTA(1), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNFAIP3(39), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10)	10847205	148	91	135	51	38	42	17	22	29	0	0.310	1.000	1.000
391	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1D1(8), ARSB(10), ARSD(9), ARSE(4), CYP11B1(13), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9)	13664275	168	90	155	48	61	23	20	27	37	0	0.0606	1.000	1.000
392	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11), MASP1(19), MASP2(10), MBL2(3)	12875350	164	90	153	60	45	18	21	38	40	2	0.820	1.000	1.000
393	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	22	ADCY1(22), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), HRAS(4), MAPK1(3), MAPK14(7), MAPK3(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RAC1(2), RPS6KA1(9), RPS6KA5(10), SOS1(11)	11762516	141	90	136	54	46	33	18	27	17	0	0.470	1.000	1.000
394	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	18	CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), IL2(4), IL2RA(3), IL2RB(4), IL2RG(8), JAK1(20), JAK3(27), JUN(2), LCK(8), MAPK3(3), MAPK8(11), SHC1(13), SOS1(11), STAT5A(8), SYK(5)	9735237	146	90	126	46	36	35	13	28	33	1	0.516	1.000	1.000
395	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	ASAH1(4), CAMP(1), CASP3(3), CERK(3), CREB1(3), CREB3(5), CREB5(5), DAG1(8), EPHB2(15), FOS(4), GNAQ(10), ITPKA(3), ITPKB(14), JUN(2), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10)	9534223	134	90	130	48	37	25	17	32	23	0	0.424	1.000	1.000
396	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	15	ADCY1(22), ARHGEF1(13), F2(9), F2R(11), GNA12(6), GNA13(3), GNAI1(3), GNAQ(10), GNB1(3), MAP3K7(7), PLCB1(22), PRKCA(5), PTK2B(13), ROCK1(27)	10108707	154	89	135	64	47	31	10	34	28	4	0.960	1.000	1.000
397	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(11), EEA1(15), GRASP(3), GSK3A(6), GSK3B(16), LYN(13), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PLCG1(17), PRKCE(4), PRKCZ(3), RAB5A(3), RAC1(2), RPS6KB1(9)	11593177	154	89	144	45	49	33	22	21	28	1	0.116	1.000	1.000
398	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(13), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPHN(16), NSF(4), SRC(3), UBQLN1(6)	6376004	134	88	124	46	33	20	14	43	24	0	0.468	1.000	1.000
399	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(7), AMD1(3), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTAP(2), MTFMT(1), MTR(13), SRM(1), TAT(14)	10647886	142	88	131	48	54	21	18	25	23	1	0.343	1.000	1.000
400	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	17	CCL11(1), CCR3(9), CFL1(2), GNAQ(10), GNB1(3), HRAS(4), LIMK1(7), MAPK1(3), MAPK3(3), MYL2(2), NOX1(4), PIK3C2G(19), PLCB1(22), PRKCA(5), PTK2(24), ROCK2(15)	9719944	133	87	125	53	33	30	12	36	21	1	0.849	1.000	1.000
401	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	33	ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), GSR(5), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH2(16), MGST1(2), MGST2(2), MGST3(1), TXNDC12(1)	9385134	145	87	130	36	32	28	23	40	22	0	0.0184	1.000	1.000
402	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), BLVRB(1), CP(18), CPOX(3), EPRS(23), FECH(3), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UROD(2), UROS(5)	14137647	148	87	129	41	38	26	18	30	36	0	0.343	1.000	1.000
403	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	18	F2(9), F2R(11), GNAI1(3), GNB1(3), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), PLA2G4A(13), PLCB1(22), PRKCA(5), PTGS1(9), PTK2(24), SRC(3), SYK(5), TBXAS1(11)	11545298	152	87	140	71	48	36	20	33	15	0	0.947	1.000	1.000
404	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	17	ADCY1(22), AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(17), IL3(6), KITLG(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), YWHAH(3)	7528590	110	86	102	38	45	26	6	19	14	0	0.282	1.000	1.000
405	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	16	CALM2(1), CALM3(1), CDKN1A(2), GNAQ(10), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SP1(6), SP3(10), SYT1(14)	9788005	118	86	107	53	32	30	13	23	20	0	0.909	1.000	1.000
406	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	11	ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), CSK(3), CTNNA1(26), CTNNA2(33), PTK2(24), PXN(2), SRC(3), VCL(9)	8449723	135	86	127	55	49	20	12	33	20	1	0.715	1.000	1.000
407	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	20	AKT1(11), AXIN1(8), CCND1(2), CD14(6), FZD1(7), GJA1(5), GNAI1(3), GSK3B(16), IRAK1(6), LBP(7), LEF1(9), LY96(4), MYD88(3), NFKB1(8), PDPK1(4), PPP2CA(3), RELA(9), TIRAP(5), TLR4(15), TOLLIP(5)	8603640	136	86	129	42	41	35	18	19	22	1	0.107	1.000	1.000
408	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	19	BCAR1(5), CXCL12(2), CXCR4(6), GNAI1(3), GNAQ(10), GNB1(3), HRAS(4), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(19), PLCG1(17), PRKCA(5), PTK2(24), PTK2B(13), PXN(2), RELA(9)	10670926	136	85	129	66	34	32	15	31	23	1	0.985	1.000	1.000
409	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(9), SMPD2(3), SPTLC1(11), SPTLC2(9), UGCG(9)	11380855	154	85	146	52	45	27	21	42	19	0	0.317	1.000	1.000
410	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(4), ALOX5(12), CYP1A2(10), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), HSD3B7(3), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), RDH11(3), RDH12(6), RDH13(4), RDH14(1)	12588066	151	85	145	53	50	33	18	38	11	1	0.306	1.000	1.000
411	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(12), ADCY1(22), CAP1(4), CCNB1(8), CDC25C(5), GNAI1(3), GNB1(3), HRAS(4), MAPK1(3), MAPK3(3), MYT1(20), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RPS6KA1(9), SRC(3)	9276848	126	85	121	43	51	25	17	23	10	0	0.135	1.000	1.000
412	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(5), CSNK1D(14), DRD1(9), DRD2(7), GRM1(32), PLCB1(22), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	8141009	125	84	113	46	40	32	7	27	19	0	0.566	1.000	1.000
413	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	17	GH1(4), GHR(12), HRAS(4), INSR(20), IRS1(17), MAPK1(3), MAPK3(3), PLCG1(17), PRKCA(5), PTPN6(4), RPS6KA1(9), SHC1(13), SLC2A4(7), SOS1(11), SRF(4), STAT5A(8)	11360433	141	84	127	67	41	25	21	31	22	1	0.981	1.000	1.000
414	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(5), ABP1(4), AOC2(12), AOC3(9), CES1(13), ESCO1(16), ESCO2(13), LIPA(3), MYST3(28), MYST4(25), NAT6(2), PLA1A(8), PNPLA3(6), PPME1(2), PRDX6(4), SH3GLB1(5)	12297191	155	84	142	61	43	29	19	36	27	1	0.773	1.000	1.000
415	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(4), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), DDOST(4), DPAGT1(12), DPM1(3), FUT8(10), MAN1A1(12), MAN1B1(7), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), RPN1(4), RPN2(6), ST6GAL1(3)	9567334	136	84	122	43	39	29	17	27	24	0	0.499	1.000	1.000
416	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	13	ERCC3(18), GTF2A1(5), GTF2E1(13), GTF2F1(5), HDAC3(3), NCOA1(13), NCOA2(21), NCOA3(14), NCOR2(38), POLR2A(12), RARA(5), RXRA(8), TBP(2)	11893944	157	84	142	76	44	27	26	29	31	0	0.994	1.000	1.000
417	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(23), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP7(3), CASP8(19), CASP9(5), DFFA(4), DFFB(2), GZMB(4), PRF1(7), SCAP(6), SREBF1(8), SREBF2(9)	8877382	116	84	102	44	25	20	13	31	27	0	0.808	1.000	1.000
418	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(10), F13A1(12), F2(9), F2R(11), FGA(19), FGB(4), FGG(7), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8)	7190582	128	83	120	52	31	23	22	31	21	0	0.838	1.000	1.000
419	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	26	ATG3(2), ATG7(1), BECN1(2), GABARAPL1(1), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(25), PIK3R4(20), PRKAA1(8), PRKAA2(15), ULK2(14), ULK3(3)	9741846	138	83	126	41	23	31	21	42	20	1	0.290	1.000	1.000
420	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR7(5), CD28(4), CD4(4), CXCR3(4), CXCR4(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18R1(13), IL2(4), IL4(5), IL4R(6), TGFB1(2), TGFB2(6), TGFB3(2)	10650676	133	83	123	57	28	30	17	39	18	1	0.850	1.000	1.000
421	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(5), CREBBP(68), DFFA(4), DFFB(2), GZMA(8), GZMB(4), HMGB2(2), NME1(1), PRF1(7), SET(6)	5419971	108	83	103	46	29	25	14	23	17	0	0.796	1.000	1.000
422	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(11), ACO2(7), CS(2), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), PC(12), PCK1(3), SDHA(12), SDHB(3), SUCLA2(6), SUCLG1(2), SUCLG2(1)	10145375	107	82	100	40	34	16	17	24	16	0	0.501	1.000	1.000
423	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), XYLB(6)	13427435	161	82	145	42	31	26	19	43	42	0	0.281	1.000	1.000
424	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), TNFAIP3(39), TRAF3(10), TRAF6(4)	8778194	125	81	115	40	31	34	13	21	26	0	0.288	1.000	1.000
425	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	21	CALM2(1), CALM3(1), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), HDAC5(13), MEF2A(5), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(3), PPP3CB(10), PPP3CC(5), SLC2A4(7), SYT1(14), YWHAH(3)	9687724	124	81	117	59	37	28	10	26	23	0	0.948	1.000	1.000
426	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	8	CSF1R(15), EGF(7), PDGFRA(56), PRKCA(5), SH3GLB1(5), SH3GLB2(6), SH3KBP1(8), SRC(3)	6319723	105	80	96	52	15	34	16	28	10	2	0.945	1.000	1.000
427	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	22	ATF1(5), CASP2(8), CRADD(3), IKBKB(7), IKBKG(2), JUN(2), LTA(1), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP4K2(5), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNF(1), TNFRSF1A(4), TRAF2(8)	10891573	130	80	123	51	38	28	17	24	23	0	0.663	1.000	1.000
428	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(4), CR1(19), CR2(20), FCGR2B(2), HLA-DRB1(6), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27)	7317534	116	79	113	40	29	16	20	25	24	2	0.559	1.000	1.000
429	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(16), CD2(7), CD33(2), CD5(7), CD7(4), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(16), TLR2(7), TLR4(15), TLR7(15), TLR9(12)	9572799	133	79	123	55	43	22	16	37	13	2	0.696	1.000	1.000
430	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), NAGLU(5), SPAM1(9)	10144481	141	79	130	44	43	33	12	36	17	0	0.228	1.000	1.000
431	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), SLC33A1(9), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7)	7990629	119	79	108	41	43	30	12	24	10	0	0.314	1.000	1.000
432	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(11), IL2RG(8), IL4(5), IL4R(6), IRS1(17), JAK1(20), JAK3(27), RPS6KB1(9), SHC1(13), STAT6(4)	6925196	120	79	97	32	31	22	17	16	33	1	0.245	1.000	1.000
433	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	25	AHCY(7), CARM1(3), CBS(3), CTH(5), HEMK1(1), LCMT1(1), LCMT2(6), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), METTL2B(2), METTL6(5), PAPSS1(4), PAPSS2(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SCLY(11), SEPHS1(5), SEPHS2(5), WBSCR22(2)	12021219	131	78	128	44	37	23	18	34	19	0	0.311	1.000	1.000
434	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), GLCE(5), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), NDST1(9), NDST2(9), NDST3(15), NDST4(13)	10448192	128	78	125	48	51	24	13	24	16	0	0.608	1.000	1.000
435	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	23	AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11)	10592944	123	78	116	48	38	23	17	23	22	0	0.775	1.000	1.000
436	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	18	CCR5(11), CD3D(4), CD3E(2), CXCR3(4), ETV5(13), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), JUN(2), MAP2K6(4), MAPK14(7), MAPK8(11), STAT4(10), TYK2(5)	8288401	114	77	105	48	22	26	19	32	15	0	0.827	1.000	1.000
437	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), SELE(11), SELL(5), SELP(13)	8115760	111	77	110	36	38	20	11	23	19	0	0.271	1.000	1.000
438	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11)	9972928	120	77	113	45	36	23	17	23	21	0	0.712	1.000	1.000
439	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(3), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(5), EDN1(3), EDNRA(8), EDNRB(13), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(13), PRL(3), PTGDR(7), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11)	10734350	138	77	132	49	50	17	12	39	20	0	0.492	1.000	1.000
440	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	15	CSNK2A1(7), FOS(4), HRAS(4), JUN(2), MAPK3(3), MPL(5), PLCG1(17), PRKCA(5), RASA1(20), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), THPO(5)	10296154	129	77	116	44	32	23	11	28	34	1	0.828	1.000	1.000
441	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2)	9737081	122	76	118	43	38	32	14	28	10	0	0.357	1.000	1.000
442	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(1), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), ILVBL(8), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7), VNN1(11)	8538602	128	76	121	34	28	26	23	37	13	1	0.0420	1.000	1.000
443	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(7), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTR(13)	9000806	121	76	114	38	45	20	13	21	21	1	0.276	1.000	1.000
444	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	11	ARHGEF1(13), GNA12(6), GNA13(3), GNAQ(10), GNB1(3), MYL2(2), MYLK(29), PLCB1(22), PRKCA(5), ROCK1(27)	8234658	120	76	107	49	29	19	14	29	25	4	0.912	1.000	1.000
445	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(3), CHAT(16), DBH(8), DDC(5), GAD1(15), GAD2(15), HDC(8), MAOA(5), PAH(15), PNMT(3), SLC18A3(11), TPH1(2)	6821903	108	75	100	45	37	18	11	34	8	0	0.649	1.000	1.000
446	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	14	ADAM12(13), AGT(10), EDN1(3), EDNRA(8), EDNRB(13), EGF(7), FOS(4), HRAS(4), JUN(2), MYC(5), NFKB1(8), PLCG1(17), PRKCA(5), RELA(9)	8863891	108	75	102	46	25	19	21	21	22	0	0.878	1.000	1.000
447	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(18), AP2A1(5), AP2M1(6), BIN1(3), CALM2(1), CALM3(1), DNM1(13), EPN1(9), EPS15(11), NME1(1), PICALM(8), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYNJ1(24), SYNJ2(14), SYT1(14)	11587367	146	75	133	62	38	27	16	36	29	0	0.865	1.000	1.000
448	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11)	10836621	132	74	121	44	37	13	16	27	37	2	0.729	1.000	1.000
449	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(9), F2R(11), F3(1), F5(30), F7(6), FGA(19), FGB(4), FGG(7), PROC(3), PROS1(9), SERPINC1(8), TFPI(6)	8417194	118	74	110	46	31	24	17	32	14	0	0.738	1.000	1.000
450	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	24	AKR1B1(3), ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), GCK(3), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), KHK(4), MPI(4), PFKFB1(12), PFKFB3(2), PFKFB4(5), PFKM(2), PFKP(15), PMM1(3), PMM2(2), TPI1(3)	11894894	123	74	116	53	49	18	13	24	19	0	0.808	1.000	1.000
451	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AGPS(5), CHPT1(3), ENPP2(23), ENPP6(10), PAFAH1B1(6), PAFAH2(6), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PPAP2A(2), PPAP2B(2), PPAP2C(3)	12152391	136	74	128	61	44	27	17	32	16	0	0.944	1.000	1.000
452	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	21	ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME3(7), PGK1(3), PGK2(9), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TKTL1(7), TPI1(3)	9173363	106	74	102	40	29	13	13	37	14	0	0.658	1.000	1.000
453	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(2), IL6(5), IL6R(7), JAK1(20), JAK3(27), PIAS3(10), PTPRU(18), REG1A(6), SRC(3), STAT3(10)	6550148	108	74	94	35	39	21	19	13	16	0	0.228	1.000	1.000
454	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	12	CD28(4), CD3D(4), CD3E(2), CD80(4), CD86(2), CTLA4(4), HLA-DRB1(6), ICOS(2), IL2(4), ITK(21), LCK(8), PTPN11(31)	4043053	92	73	75	30	14	35	11	20	10	2	0.453	1.000	1.000
455	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	14	AKT1(11), CREB1(3), HRAS(4), MAPK1(3), MAPK3(3), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NTRK1(16), PLCG1(17), RPS6KA1(9), SHC1(13)	7476989	108	73	100	44	31	22	17	17	20	1	0.849	1.000	1.000
456	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(12), BST1(2), C9orf95(2), CD38(4), ENPP1(17), ENPP3(10), NADK(5), NADSYN1(4), NMNAT1(2), NMNAT2(4), NMNAT3(4), NNMT(4), NNT(5), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT12(3), QPRT(2)	11397771	123	73	117	42	37	26	16	29	14	1	0.219	1.000	1.000
457	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(6), FOS(4), GNAQ(10), JUN(2), MAPK14(7), MAPK8(11), PLCG1(17), PRKCA(5), PTK2B(13), SYT1(14)	7104158	105	72	95	46	21	27	9	31	17	0	0.953	1.000	1.000
458	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), PAK1(10), PDGFRA(56), RAC1(2), WASL(16)	5171551	112	72	100	39	20	29	16	32	13	2	0.473	1.000	1.000
459	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CMBL(1), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), PON1(11), PON2(6), PON3(10)	8728048	124	72	115	40	33	29	13	28	20	1	0.310	1.000	1.000
460	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(11), BAD(1), CHRNB1(10), CHRNG(6), MUSK(13), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(8), YWHAH(3)	6139996	97	71	90	38	27	22	13	18	17	0	0.671	1.000	1.000
461	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PGK1(3), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TPI1(3)	8714284	99	71	95	32	25	14	14	32	14	0	0.329	1.000	1.000
462	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	16	BAD(1), BCL2(2), CASP8(19), CYCS(1), FADD(1), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFKB1(8), NSMAF(10), RELA(9), RIPK1(7), SMPD1(9), TNFRSF1A(4), TRAF2(8)	8626706	114	71	107	33	35	22	10	22	25	0	0.156	1.000	1.000
463	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(12), PGAP1(11), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGW(2), PIGX(2), PIGZ(6)	12374706	111	71	103	48	18	28	9	33	23	0	0.954	1.000	1.000
464	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5)	8323582	116	71	102	46	29	26	12	26	22	1	0.850	1.000	1.000
465	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(20), ABCC2(18), ABCG2(12), CES1(13), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9)	11602723	133	71	116	49	39	24	17	26	26	1	0.598	1.000	1.000
466	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(9), ACADS(3), ACADVL(6), ACSL1(9), ACSL3(11), ACSL4(10), CPT1A(10), CPT2(2), DCI(3), EHHADH(13), HADHA(10), SCP2(6), SLC25A20(1)	8818945	97	71	90	36	25	18	14	25	15	0	0.483	1.000	1.000
467	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), NCKAP1(15), NTRK1(16), PIR(1), PSMA7(1), RAC1(2), WASF1(3), WASF2(5), WASF3(14), WASL(16)	8126706	111	70	105	38	30	13	16	32	20	0	0.534	1.000	1.000
468	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	23	ALDOA(2), ALDOC(1), DERA(4), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKL(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TALDO1(4), TKT(6), TKTL1(7)	10484024	115	69	111	48	43	13	17	30	12	0	0.695	1.000	1.000
469	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(1), IARS(9), IARS2(19), ILVBL(8), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3), VARS(7), VARS2(9)	8561493	99	69	98	34	39	17	14	14	15	0	0.478	1.000	1.000
470	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(23), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(5), BIRC3(11), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), DIABLO(3), ENDOG(3)	6831860	92	69	80	28	17	16	13	24	22	0	0.479	1.000	1.000
471	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2)	7949587	105	69	101	31	31	28	13	23	10	0	0.131	1.000	1.000
472	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	12	EGF(7), HRAS(4), MAPK1(3), MAPK3(3), PTPRB(19), RASA1(20), SHC1(13), SOS1(11), SPRY1(9), SPRY2(2), SPRY4(7), SRC(3)	8600961	101	69	90	33	19	22	14	21	24	1	0.637	1.000	1.000
473	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	CISH(2), JAK1(20), JAK3(27), PIAS1(4), PIAS3(10), PTPRU(18), REG1A(6), SOAT1(6)	5675504	93	69	83	29	33	20	13	11	16	0	0.253	1.000	1.000
474	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(5), ALDH18A1(8), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), GAMT(6), GATM(2), GLUD1(4), NAGS(5), OAT(3), ODC1(5), OTC(14), SMS(4)	8948451	111	69	103	32	29	26	19	24	13	0	0.125	1.000	1.000
475	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(23), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(3), CASP8(19), CASP9(5), CYCS(1), GZMB(4), JUN(2), PRF1(7)	5164230	82	68	70	30	17	16	8	19	22	0	0.774	1.000	1.000
476	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), CHST1(9), CHST2(11), CHST4(6), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	5473752	92	68	88	31	45	17	4	14	12	0	0.516	1.000	1.000
477	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	13	MAP3K14(6), MAPK14(7), MAPK8(11), NFKB1(8), RELA(9), TNFRSF13B(6), TNFRSF17(4), TNFSF13(2), TNFSF13B(3), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4)	6534453	89	68	83	29	33	15	8	15	18	0	0.450	1.000	1.000
478	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(29), ABCB11(19), ABCB4(23), ABCC1(20), ABCC3(10), GSTP1(1)	7369488	102	67	105	33	18	16	16	27	23	2	0.536	1.000	1.000
479	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	12	AKT1(11), AKT2(7), AKT3(7), CDKN1A(2), ELK1(4), HRAS(4), MAP2K2(2), NGFR(4), NTRK1(16), PIK3CD(10), SHC1(13), SOS1(11)	6078525	91	67	83	40	27	10	16	19	18	1	0.906	1.000	1.000
480	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(23), C5(20), C6(24), C7(10), C8A(11), C9(11)	6634264	99	66	91	32	30	11	13	22	22	1	0.456	1.000	1.000
481	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(22), GNB1(3), PPP2CA(3), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	6886995	94	66	89	36	32	19	7	19	17	0	0.640	1.000	1.000
482	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(56), NRG2(6), NRG3(14), PRKCA(5), PSEN1(3)	4774191	95	66	88	36	17	21	18	25	14	0	0.678	1.000	1.000
483	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(4), HRAS(4), JUN(2), MAPK3(3), MAPK8(11), PLCG1(17), PTPN6(4), SHC1(13), SOS1(11), STAT5A(8)	7626760	91	65	82	38	26	15	8	19	22	1	0.952	1.000	1.000
484	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), IDS(5), LCT(39), NAGLU(5)	7169816	92	65	86	30	34	19	8	22	9	0	0.218	1.000	1.000
485	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELE(11), SELL(5)	6237051	85	65	82	32	26	16	7	18	18	0	0.635	1.000	1.000
486	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	21	ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TAL1(2), TALDO1(4), TKT(6)	9337202	99	65	95	40	37	12	12	28	10	0	0.658	1.000	1.000
487	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(20), ESR2(8), ITPKA(3), PDE1A(8), PDE1B(10), PLCB1(22), PLCB2(10), PRL(3), TRH(7), VIP(3)	5653105	94	65	87	34	27	17	13	21	16	0	0.561	1.000	1.000
488	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	8	CD3D(4), CD3E(2), CD4(4), FYN(15), HLA-DRB1(6), LCK(8), PTPRC(27), ZAP70(12)	4220464	78	65	66	26	19	17	12	11	17	2	0.348	1.000	1.000
489	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	15	ATF2(6), IFNG(3), IKBKB(7), IL2(4), IL4(5), JUN(2), MAP3K1(18), MAP3K5(14), MAP4K5(4), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), TRAF2(8)	8977746	107	64	103	28	31	23	13	25	15	0	0.111	1.000	1.000
490	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(4), LCT(39), MPI(4), PGM1(8), PYGL(6), PYGM(10), TPI1(3), TREH(6)	6970708	93	64	87	29	26	20	15	26	6	0	0.155	1.000	1.000
491	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), PHPT1(2), RFK(1), TYR(9)	7930988	108	64	97	31	30	29	12	20	16	1	0.160	1.000	1.000
492	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1)	12162862	101	64	98	28	28	15	22	20	16	0	0.158	1.000	1.000
493	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(12), APAF1(23), BCL2(2), CASP3(3), CASP9(5), CYCS(1), DAXX(14), FAS(7), FASLG(3), HSPB2(2), IL1A(1), MAPKAPK2(4), MAPKAPK3(6), TNF(1)	5583459	84	64	70	36	17	22	11	13	21	0	0.926	1.000	1.000
494	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	10	IL10RA(3), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(20), JAK3(27), STAT1(15), STAT3(10), STAT5A(8), TYK2(5)	7184531	96	64	83	32	28	25	8	19	16	0	0.498	1.000	1.000
495	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	13	CSNK2A1(7), DPM2(1), ELK1(4), FOS(4), HRAS(4), JUN(2), KLK2(4), MAPK3(3), MAPK8(11), NGFR(4), PLCG1(17), SHC1(13), SOS1(11)	6288337	85	64	77	32	22	15	9	18	20	1	0.877	1.000	1.000
496	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	9	AKT1(11), DPM2(1), HRAS(4), KLK2(4), NTRK1(16), PLCG1(17), PRKCA(5), SHC1(13), SOS1(11)	5820663	82	64	70	37	14	15	16	17	19	1	0.963	1.000	1.000
497	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	8	EGF(7), MAP3K1(18), MAPK14(7), NCOR2(38), RARA(5), RXRA(8), THRA(6), THRB(14)	6539226	103	63	92	34	29	16	14	18	26	0	0.641	1.000	1.000
498	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(1), MRPL13(6), MRPS7(4), RPL10A(2), RPL10L(4), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(2), RPL7(3), RPL8(3), RPL9(3), RPS10(2), RPS11(2), RPS13(2), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS5(2), RPS6(2), RPS7(1), RPS9(3), RPSA(1)	10355172	103	63	99	28	27	23	16	24	13	0	0.220	1.000	1.000
499	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(4), CSF3(2), HLA-DRB1(6), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL11(6), IL12A(1), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), LTA(1), PDGFA(2), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1)	6544903	87	63	79	39	26	16	7	24	11	3	0.895	1.000	1.000
500	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(30), CPT1A(10), LEP(1), LEPR(15), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6)	7781487	97	63	94	28	29	9	11	31	17	0	0.426	1.000	1.000
501	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37)	8638137	106	62	93	33	34	13	17	27	15	0	0.324	1.000	1.000
502	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(2), ATIC(13), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4)	9719681	94	62	88	45	29	14	14	19	16	2	0.951	1.000	1.000
503	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(2), BNIP1(5), GOSR1(4), GOSR2(5), SEC22B(3), SNAP23(2), SNAP25(1), SNAP29(4), STX11(6), STX12(6), STX16(7), STX17(1), STX18(2), STX19(3), STX2(5), STX3(3), STX4(3), STX5(10), STX6(2), STX7(3), STX8(5), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(3), VAMP4(3), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1)	8341316	108	62	96	31	34	11	11	22	30	0	0.435	1.000	1.000
504	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	15	IL18(3), ITGB1(12), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LAT(2), MAPK3(3), PAK1(10), PTK2B(13), PTPN6(4), RAC1(2), SYK(5), VAV1(22)	6966558	93	62	89	36	26	25	7	24	11	0	0.712	1.000	1.000
505	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	14	AKT1(11), BCL2(2), BCR(11), CRKL(5), FOS(4), HRAS(4), JUN(2), MAP3K1(18), MAPK3(3), MAPK8(11), MYC(5), SOS1(11), STAT1(15), STAT5A(8)	8180474	110	61	107	34	34	20	15	24	17	0	0.199	1.000	1.000
506	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	10	AKT1(11), CAT(7), GH1(4), GHR(12), HRAS(4), IGF1(6), IGF1R(17), SHC1(13), SOD2(4)	4732422	78	61	68	27	26	9	11	17	14	1	0.464	1.000	1.000
507	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(11), PLCB1(22), PLCG1(17), PRKCA(5), VAV1(22)	4847551	77	61	71	33	25	21	11	14	6	0	0.793	1.000	1.000
508	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	11	ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(20), CLTA(5), CLTB(2), COPA(13), GBF1(17), GPLD1(12), KDELR1(5), KDELR3(2)	8292486	88	60	87	34	25	15	10	19	19	0	0.825	1.000	1.000
509	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(15), PSMD11(8), PSMD12(4), PSMD13(6), PSMD2(3), PSMD6(5)	8627918	81	59	76	36	20	21	11	18	11	0	0.897	1.000	1.000
510	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(2), ATIC(13), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4)	9430955	89	59	82	43	26	15	13	18	15	2	0.949	1.000	1.000
511	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(4), CD3D(4), CD3E(2), CD4(4), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27)	5619971	86	59	81	35	22	14	13	18	19	0	0.787	1.000	1.000
512	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(10), FOS(4), JUN(2), MAPK3(3), OPRK1(12), POLR2A(12), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4)	6640353	71	58	68	19	26	13	5	12	15	0	0.155	1.000	1.000
513	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	14	ADRB2(3), AKT1(11), ANXA1(3), CALM2(1), CALM3(1), GNB1(3), NFKB1(8), NOS3(21), NPPA(1), NR3C1(8), RELA(9), SYT1(14)	5864750	83	58	69	30	22	24	9	13	15	0	0.582	1.000	1.000
514	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2)	7099195	77	58	77	30	15	19	8	24	11	0	0.782	1.000	1.000
515	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9)	8920638	89	58	75	27	25	13	11	12	28	0	0.538	1.000	1.000
516	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), FDXR(5), SHMT1(6)	7873082	88	58	79	38	28	23	11	15	11	0	0.800	1.000	1.000
517	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(6), JAK1(20), PTPRU(18), REG1A(6), STAT1(15), STAT2(10), TYK2(5)	6410913	87	58	81	21	30	20	8	16	13	0	0.0846	1.000	1.000
518	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	14	CD28(4), CD3D(4), CD3E(2), IFNG(3), IL2(4), IL2RA(3), IL4(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14), TOB2(2)	5076433	92	58	80	36	33	20	10	16	13	0	0.641	1.000	1.000
519	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(6), CYB5R3(1), GCK(3), GFPT1(5), GNE(7), GNPDA1(2), GNPDA2(3), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), PGM3(5), RENBP(3), UAP1(6)	8750177	83	57	80	29	26	21	8	17	11	0	0.525	1.000	1.000
520	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	7519622	83	57	74	37	27	22	11	13	10	0	0.833	1.000	1.000
521	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	7519622	83	57	74	37	27	22	11	13	10	0	0.833	1.000	1.000
522	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(4), GALNT10(8), GALNT2(10), GALNT3(15), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GCNT1(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4)	6850435	79	57	77	37	29	15	12	9	14	0	0.881	1.000	1.000
523	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(4), CD3D(4), CD3E(2), CD8A(1), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27)	5275922	83	57	78	33	23	14	11	17	18	0	0.740	1.000	1.000
524	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(4), CD86(2), HLA-DRB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), IL2(4), IL2RA(3), IL4(5), IL4R(6)	6326465	81	57	74	30	18	15	10	22	13	3	0.626	1.000	1.000
525	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6)	7519622	83	57	74	37	27	22	11	13	10	0	0.833	1.000	1.000
526	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	14	B3GAT1(6), B3GAT2(1), B3GAT3(1), B4GALT7(2), CHPF(10), CHST11(4), CHST12(4), CHST14(1), CHST3(6), CHSY1(14), DSE(9), UST(10), XYLT1(12)	5802932	80	56	72	40	34	13	12	13	7	1	0.863	1.000	1.000
527	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL15(1), IL16(14), IL18(3), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL8(5), IL9(1), LTA(1), TNF(1)	5013721	68	55	61	36	20	15	6	20	7	0	0.931	1.000	1.000
528	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(3), ALOX15(4), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(2), LTA4H(2), PLA2G6(8), PTGDS(2), PTGES(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11)	7036192	81	55	80	35	28	11	11	21	10	0	0.759	1.000	1.000
529	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), NAT1(1), NAT2(3), XDH(19)	4269526	68	55	64	30	22	13	9	18	6	0	0.832	1.000	1.000
530	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	15	AKT1(11), BAD(1), BCL2L1(1), CASP9(5), CDC42(2), ELK1(4), H2AFX(1), HRAS(4), MAPK3(3), NFKB1(8), RAC1(2), RALA(7), RALBP1(6), RALGDS(7), RELA(9)	5557083	71	55	67	25	29	11	12	9	10	0	0.337	1.000	1.000
531	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(20), JAK3(27), MAPK1(3), MAPK3(3), STAT3(10), TYK2(5)	4652839	68	55	56	21	21	20	6	11	10	0	0.423	1.000	1.000
532	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	13	CUZD1(8), FOS(4), HRAS(4), JUN(2), MAPK1(3), MAPK3(3), MYC(5), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RELA(9), TNF(1)	6656461	75	54	71	35	18	14	13	16	14	0	0.905	1.000	1.000
533	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	10	ADCY1(22), ADRB2(3), CFTR(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SLC9A3R1(3)	5617093	69	54	66	25	21	17	3	18	10	0	0.453	1.000	1.000
534	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(5), FDFT1(3), FDPS(6), GGCX(8), GGPS1(4), HMGCR(6), IDI1(4), IDI2(3), LSS(4), MVD(3), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1), TM7SF2(2)	9328085	80	54	78	31	23	8	12	23	14	0	0.812	1.000	1.000
535	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(12), CD38(4), ENPP1(17), ENPP3(10), NADSYN1(4), NMNAT1(2), NMNAT2(4), NNMT(4), NNT(5), NT5C(1), NT5E(6), NT5M(3), QPRT(2)	7785195	74	54	68	23	21	18	9	17	8	1	0.146	1.000	1.000
536	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(10), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(2), CDK5R1(5), CSNK1A1(3), CSNK1D(14), GSK3B(16), MAPT(10), PPP2CA(3)	4347482	73	54	70	23	25	17	5	16	10	0	0.357	1.000	1.000
537	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(2), EPO(1), FLT3(27), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(6), TGFB3(2)	4375309	68	53	62	34	18	17	4	18	10	1	0.964	1.000	1.000
538	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(6), IL10(1), IL10RA(3), IL10RB(6), IL1A(1), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(8), TNF(1)	6253500	79	53	70	31	25	14	6	19	15	0	0.755	1.000	1.000
539	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(13), ADSS(5), DHFR(1), HPRT1(2), IMPDH1(3), MTHFD2(2), POLB(4), POLD1(18), POLG(8), PRPS2(6), RRM1(2), SRM(1)	6276418	65	53	63	26	24	6	10	12	13	0	0.729	1.000	1.000
540	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(4), FOSL1(1), FOSL2(4), IFNAR1(7), IFNAR2(3), IFNB1(6), MAPK8(11), NFKB1(8), RELA(9), TNFRSF11A(5), TNFSF11(8), TRAF6(4)	5597305	70	53	68	24	19	15	9	12	15	0	0.410	1.000	1.000
541	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(16), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(2), CDK2(5), CDK4(3), CDKN1B(4), CDKN2A(7), E2F2(7), E2F4(2), PRB1(3)	4415905	61	53	57	23	13	12	9	18	9	0	0.595	1.000	1.000
542	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(16), CKM(6), FBL(6), GPT(6), LDHA(10), LDHB(5), LDHC(4), MAPK14(7), NCL(10)	4545633	70	53	63	27	17	16	10	20	7	0	0.634	1.000	1.000
543	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(10), GNB1(3), HTR2C(13), PLCB1(22), TUB(13)	3723592	65	53	64	26	26	12	7	15	5	0	0.654	1.000	1.000
544	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	13	CALM2(1), CALM3(1), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CAMKK1(2), CAMKK2(8), CREB1(3), SYT1(14)	5507579	66	52	60	33	15	18	7	13	13	0	0.946	1.000	1.000
545	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2)	7032103	68	51	70	32	14	16	7	20	11	0	0.966	1.000	1.000
546	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	13	CCR5(11), CD2(7), CD3D(4), CD3E(2), CD4(4), CXCR3(4), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), STAT4(10), TYK2(5)	6280228	72	51	66	28	10	16	14	22	10	0	0.716	1.000	1.000
547	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	9	CSF2RB(13), FOS(4), HRAS(4), IL3(6), MAPK3(3), PTPN6(4), SHC1(13), SOS1(11), STAT5A(8)	5202160	66	50	57	23	20	11	4	11	19	1	0.796	1.000	1.000
548	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(6), UBE2A(4), UBE3A(19)	6949809	72	50	69	29	18	16	10	16	12	0	0.740	1.000	1.000
549	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	7	CD3D(4), CD3E(2), GZMB(4), ICAM1(4), ITGAL(18), ITGB2(16), PRF1(7)	3616766	55	49	52	24	26	8	3	6	12	0	0.763	1.000	1.000
550	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	11	AHCY(7), CBS(3), CTH(5), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), PAPSS1(4), PAPSS2(5), SCLY(11), SEPHS1(5)	5874445	70	49	65	20	24	8	11	15	12	0	0.145	1.000	1.000
551	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(5), MAX(5), MYC(5), SP1(6), SP3(10), WT1(28)	3132555	59	49	52	28	11	19	14	9	6	0	0.800	1.000	1.000
552	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10)	4818345	67	48	66	22	19	9	7	22	10	0	0.494	1.000	1.000
553	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(6), FARSB(11), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4), YARS2(6)	4613164	69	48	63	21	18	8	10	22	11	0	0.393	1.000	1.000
554	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), IMPA2(3), ISYNA1(6), PGM1(8), PGM3(5)	5688831	65	48	62	31	23	11	7	16	8	0	0.858	1.000	1.000
555	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(5), B3GALT5(3), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST8SIA1(10)	5160355	71	48	69	23	23	8	8	22	10	0	0.435	1.000	1.000
556	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), SIRT1(7), SIRT2(2), SIRT5(2), SIRT7(3), VNN2(4)	5826348	57	48	55	19	20	9	9	10	9	0	0.371	1.000	1.000
557	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	12	CYSLTR1(9), GPR109B(5), GPR161(10), GPR171(10), GPR18(3), GPR34(10), GPR39(3), GPR45(11), GPR65(1), GPR68(5), GPR75(9)	4747692	76	47	67	35	20	14	6	20	15	1	0.959	1.000	1.000
558	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	3915509	58	47	53	17	23	13	3	11	8	0	0.429	1.000	1.000
559	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(10), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RELA(9)	4316122	55	47	52	21	15	12	7	13	8	0	0.662	1.000	1.000
560	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(10), NEK1(20)	3202331	57	47	52	19	10	11	3	16	16	1	0.845	1.000	1.000
561	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(12), CD44(5), CSF1(4), FCGR3A(4), IL1B(4), IL6R(7), SELL(5), SPN(4), TGFB1(2), TGFB2(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(7), TNFSF8(4)	6662233	70	47	69	21	22	8	12	16	12	0	0.211	1.000	1.000
562	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(16), CHKA(4), PCYT1A(4), PDHA1(7), PDHA2(14), PEMT(2), SLC18A3(11)	3473981	61	45	60	36	26	9	10	11	5	0	0.942	1.000	1.000
563	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	11	AKT1(11), BAD(1), CASP9(5), GH1(4), GHR(12), NFKB1(8), NFKBIA(1), PDPK1(4), PPP2CA(3), RELA(9), YWHAH(3)	4621331	61	45	56	24	20	11	10	14	6	0	0.622	1.000	1.000
564	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(3), HBXIP(4), HRAS(4), PTK2B(13), SHC1(13), SOS1(11), SRC(3)	4250933	51	45	45	16	7	7	8	12	16	1	0.735	1.000	1.000
565	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(5), B3GALT1(3), B3GALT2(10), B3GALT5(3), B3GNT5(3), FUT1(8), FUT2(6), FUT3(4), ST3GAL3(12), ST3GAL4(4)	3540206	58	45	55	22	26	6	3	14	9	0	0.706	1.000	1.000
566	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(25), GNA12(6), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4)	5350557	54	44	52	15	13	8	7	15	11	0	0.354	1.000	1.000
567	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13)	6380793	63	44	61	19	22	12	7	12	10	0	0.430	1.000	1.000
568	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(15), EGF(7), HGS(10), RAB5A(3), TF(16), TFRC(5)	5294259	56	43	48	18	11	15	6	10	13	1	0.338	1.000	1.000
569	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	ARNT(8), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(14), NFKB1(8), NFKBIA(1), RELA(9), SOD2(4)	5265739	54	43	52	16	13	9	9	11	12	0	0.350	1.000	1.000
570	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	7	CAMK1G(5), HDAC9(18), MEF2A(5), MEF2C(15), MEF2D(3), YWHAH(3)	3326913	49	42	56	26	16	7	2	16	7	1	0.968	1.000	1.000
571	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(2), ENO3(5), FARS2(5), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4)	4455212	56	42	51	24	13	7	12	17	7	0	0.840	1.000	1.000
572	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	8	CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CSK(3), PRKCA(5), PTPRA(5), SRC(3)	4553477	51	42	51	22	13	12	5	16	5	0	0.766	1.000	1.000
573	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3)	3882671	52	41	52	23	26	6	6	7	7	0	0.746	1.000	1.000
574	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ENO1(3), GPI(5), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(11), TPI1(3)	3979895	49	41	46	23	19	7	4	13	6	0	0.874	1.000	1.000
575	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3)	3882671	52	41	52	23	26	6	6	7	7	0	0.746	1.000	1.000
576	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), PGM1(8), PGM3(5)	5185687	56	41	53	27	19	10	6	15	6	0	0.879	1.000	1.000
577	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(9), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3)	5306104	55	41	55	23	17	11	9	10	8	0	0.786	1.000	1.000
578	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NFS1(5), PHPT1(2), THTPA(2), TPK1(5)	3347996	47	40	43	14	14	12	5	8	8	0	0.393	1.000	1.000
579	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(12), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(5), APOBEC3F(1), APOBEC3G(6), APOBEC4(7)	3914814	48	38	47	15	19	4	9	8	8	0	0.365	1.000	1.000
580	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	11	CD2(7), CD34(7), CD3D(4), CD3E(2), CD4(4), CD8A(1), CSF3(2), IL3(6), IL6(5), IL8(5), KITLG(3)	2910538	46	38	40	21	8	13	5	12	8	0	0.776	1.000	1.000
581	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(9), MBTPS1(11), MBTPS2(2), SCAP(6), SREBF1(8), SREBF2(9)	5502059	46	38	45	25	13	10	8	8	7	0	0.884	1.000	1.000
582	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(3), CD36(3), FOS(4), FYN(15), JUN(2), MAPK14(7), THBS1(12)	3778936	46	37	42	17	12	7	6	8	13	0	0.533	1.000	1.000
583	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	10	ARRB1(4), GNB1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5)	3990321	37	36	37	25	10	11	1	7	8	0	0.985	1.000	1.000
584	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(12), AOC3(9), CES1(13), ESD(4)	2998414	42	36	41	17	15	6	6	10	5	0	0.624	1.000	1.000
585	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), IDI1(4), LSS(4), MVD(3), NQO1(1), NQO2(2), PMVK(2), SC5DL(7), SQLE(1)	5018238	43	36	41	15	13	7	6	13	4	0	0.498	1.000	1.000
586	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	BPNT1(9), CHST11(4), CHST12(4), PAPSS1(4), PAPSS2(5), SULT1A1(4), SULT1A2(4), SULT1E1(5), SULT2A1(4), SULT2B1(4), SUOX(5)	4883015	52	36	49	18	17	8	5	14	8	0	0.565	1.000	1.000
587	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(3), FOS(4), JUN(2), KEAP1(5), MAPK1(3), MAPK14(7), MAPK8(11), NFE2L2(4), PRKCA(5)	4239099	44	35	44	21	8	9	4	16	7	0	0.925	1.000	1.000
588	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(3), DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), HMGCS1(1), IDI1(4), LSS(4), MVD(3), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1)	6186199	48	34	47	18	14	7	6	15	6	0	0.691	1.000	1.000
589	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(9), NR1H3(16), NR1H4(7), RXRA(8)	2597155	42	34	35	20	11	8	6	6	11	0	0.939	1.000	1.000
590	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(8), F13B(10), HSD17B1(2), HSD17B2(6), HSD17B3(4), HSD17B4(9), HSD3B1(5), HSD3B2(3)	4242355	47	34	45	19	16	10	7	9	5	0	0.524	1.000	1.000
591	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(5), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), ST3GAL3(12)	2030097	39	32	37	18	21	5	2	8	3	0	0.756	1.000	1.000
592	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	10	CDK5(2), CDK5R1(5), DPM2(1), EGR1(11), HRAS(4), KLK2(4), MAP2K2(2), MAPK1(3), MAPK3(3), NGFR(4)	2675811	39	32	37	17	14	3	3	10	9	0	0.751	1.000	1.000
593	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(6), PLCG1(17), PRKCA(5), PTK2B(13)	3447846	41	32	39	23	11	11	5	8	6	0	0.974	1.000	1.000
594	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(10), CYP2E1(9), NR1I3(3), PTGS1(9), PTGS2(9)	2793524	40	31	40	15	18	4	8	7	3	0	0.605	1.000	1.000
595	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(8), CYP11A1(5), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3)	3506464	39	31	38	23	17	6	6	5	5	0	0.913	1.000	1.000
596	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(11), ALAS2(10), CPOX(3), FECH(3), HMBS(4), PPOX(5), UROD(2), UROS(5)	4051107	43	31	39	11	17	7	5	8	6	0	0.360	1.000	1.000
597	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(6), GOT2(2), TAT(14), TYR(9)	2521444	36	31	30	18	10	5	9	10	2	0	0.865	1.000	1.000
598	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(8), GAD1(15), HDC(8), PNMT(3), TPH1(2)	2671897	36	30	34	17	11	6	2	13	4	0	0.862	1.000	1.000
599	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMB8(6), PSMB9(4)	4401070	37	30	36	19	9	5	5	10	8	0	0.929	1.000	1.000
600	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(9), ACADS(3), ACAT1(7), ECHS1(3), HADHA(10)	2793555	36	29	36	15	9	6	5	7	9	0	0.713	1.000	1.000
601	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), DHFR(1), FPGS(4), GGH(1), SPR(7)	2772845	35	29	34	14	11	7	5	8	4	0	0.598	1.000	1.000
602	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(7), ACAT2(8), BDH1(3), BDH2(2), HMGCS1(1), HMGCS2(5), OXCT1(3), OXCT2(3)	3844184	32	29	30	11	10	6	3	6	7	0	0.590	1.000	1.000
603	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(7), CSF1(4), IL6(5), LDLR(9), LPL(12)	2735901	37	29	35	18	10	11	3	7	6	0	0.796	1.000	1.000
604	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(12), NR3C1(8), PPARG(4), RETN(2), RXRA(8), TNF(1)	2821698	37	29	35	23	10	5	8	8	6	0	0.972	1.000	1.000
605	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12)	2342704	29	28	27	20	14	7	2	3	2	1	0.980	1.000	1.000
606	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12)	2342704	29	28	27	20	14	7	2	3	2	1	0.980	1.000	1.000
607	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	5	ADCY1(22), GNB1(3), PRKACA(1), PRKAR1A(3)	2218568	29	27	26	16	14	9	2	3	1	0	0.815	1.000	1.000
608	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(9), PRKCA(5), TGM2(15)	2559717	34	27	33	19	13	6	3	9	3	0	0.904	1.000	1.000
609	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	8	ASAH1(4), CAMP(1), CREB1(3), CREB3(5), CREB5(5), MAPK1(3), SRC(3), TERF2IP(3)	3115633	27	23	27	13	3	5	4	8	7	0	0.865	1.000	1.000
610	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(7), ARG1(2), GLS(2), GLUD1(4), OAT(3), PRODH(5)	2793487	23	22	22	10	10	6	2	1	4	0	0.668	1.000	1.000
611	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(9), HLA-DRB1(6), IL3(6)	1199864	22	21	18	10	4	8	0	7	1	2	0.922	1.000	1.000
612	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(4), CD4(4), CD80(4), HLA-DRB1(6), IL10(1), IL2(4), IL4(5)	1778678	28	20	27	11	7	3	4	8	4	2	0.770	1.000	1.000
613	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(2), TAT(14)	1417414	22	20	17	11	7	1	7	5	2	0	0.839	1.000	1.000
614	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(9), SNAP25(1), STX1A(3), VAMP2(1)	1689745	18	18	16	10	7	4	3	3	1	0	0.943	1.000	1.000
615	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(6), IFNG(3), IL12A(1), IL12B(1), IL18(3), IL2(4)	1606799	18	14	17	14	1	4	5	6	2	0	0.989	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	273768	1	1	1	2	1	0	0	0	0	0	0.955	1.000	1.000
