rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(11)	513817	11	11	11	1	9	0	1	1	0	0	0.107	0.152	1.000
2	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(9), LIPT1(13)	1090040	22	19	17	1	0	3	2	6	11	0	0.132	0.217	1.000
3	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(2), ALDOB(16), ALDOC(3), TPI1(3)	2558746	30	28	26	3	6	6	2	15	1	0	0.0266	0.677	1.000
4	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(3)	1063963	9	9	9	1	0	1	1	7	0	0	0.306	0.788	1.000
5	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(5), CD4(4), HLA-DRB1(7)	1196858	16	14	15	7	2	0	2	5	5	2	0.941	0.871	1.000
6	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPX1(5), PRKCE(6)	5195954	119	86	107	26	31	17	14	40	17	0	0.00673	0.898	1.000
7	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(12), ALDH1A2(17), BCMO1(5), RDH5(2)	2727712	36	33	35	8	10	8	5	9	4	0	0.117	0.956	1.000
8	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), GSTZ1(5), HGD(6)	1586183	15	13	14	4	1	3	5	4	2	0	0.278	0.962	1.000
9	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	2	CD3D(5), CD3E(2)	572147	7	7	4	3	0	5	1	0	1	0	0.673	0.970	1.000
10	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CDO1(3), CSAD(6), GAD1(17), GAD2(15), GGT1(11)	3850754	55	48	40	11	18	6	7	11	13	0	0.0786	0.978	1.000
11	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4)	5488463	93	66	81	13	29	20	13	21	10	0	0.000189	0.979	1.000
12	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4)	5488463	93	66	81	13	29	20	13	21	10	0	0.000189	0.979	1.000
13	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(4), CASP8(20), CFL1(2), CFLAR(3), PDE6D(2)	2623925	33	30	31	5	5	3	4	8	13	0	0.130	0.980	1.000
14	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), IL8(6), SLPI(2)	1095078	17	16	16	7	2	3	2	4	6	0	0.766	0.985	1.000
15	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(3), GGT1(11), SHMT1(7), SHMT2(5)	2503588	27	27	23	8	6	1	3	3	14	0	0.734	0.992	1.000
16	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(14), SPCS1(3), SPCS3(2)	2144483	24	21	22	6	9	3	2	7	3	0	0.201	0.997	1.000
17	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), SDS(3)	8385086	127	87	111	22	37	25	20	27	18	0	0.000222	0.999	1.000
18	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(7), B3GNT1(5), FUT1(11), FUT2(7), FUT9(10), GCNT2(26), ST8SIA1(10)	3829261	76	59	70	20	24	8	9	23	11	1	0.0900	0.999	1.000
19	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(12), CYP2C9(11)	1451222	23	21	22	5	3	8	2	9	1	0	0.292	0.999	1.000
20	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), MIOX(3), UGDH(9)	5672987	84	62	71	15	22	18	12	16	16	0	0.0117	0.999	1.000
21	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(11), CD28(5), CD3D(5), CD3E(2), CD4(4)	2096860	27	25	23	8	4	5	5	8	5	0	0.447	1.000	1.000
22	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(3), FOSB(6), GRIA2(29), PPP1R1B(1)	2306760	39	34	38	13	15	6	4	11	3	0	0.311	1.000	1.000
23	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(12), AGTR1(14), AGTR2(17), BDKRB2(6), KNG1(9), NOS3(23), REN(10)	6037396	105	68	90	20	30	9	11	29	26	0	0.0125	1.000	1.000
24	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(4), GALT(3), TGDS(1), UGDH(9), UGP2(12), UXS1(9)	3429686	38	33	39	7	8	2	6	11	11	0	0.281	1.000	1.000
25	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(10), BIRC3(18), CASP8(20), FADD(1), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	5215492	71	56	57	16	12	18	5	14	22	0	0.0851	1.000	1.000
26	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), LTB4R(2), P2RY1(8), P2RY2(8), P2RY6(6)	3529174	69	53	62	19	29	15	10	12	3	0	0.0255	1.000	1.000
27	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(4), GALT(3), TGDS(1), UGDH(9), UXS1(9)	2672136	26	25	27	6	6	2	4	6	8	0	0.490	1.000	1.000
28	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(7), ACAT2(9), ACYP1(2), ECHS1(4), EHHADH(15), GCDH(8), HADHA(12), SDHB(3), SDS(3)	5405606	63	50	57	14	15	10	11	14	13	0	0.0664	1.000	1.000
29	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(9), SUCLA2(9)	1413285	18	17	18	7	8	2	3	3	2	0	0.594	1.000	1.000
30	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(4), RANBP1(6), RANBP2(32), RANGAP1(4)	5440776	46	35	43	8	8	7	6	17	8	0	0.0692	1.000	1.000
31	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(6), GLUD1(4), GLUD2(22)	3043522	34	32	34	9	12	6	2	12	2	0	0.368	1.000	1.000
32	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(14), RAB11A(4), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(4), RAB6A(4), RAB9A(3)	2927576	42	33	40	12	13	6	9	6	8	0	0.224	1.000	1.000
33	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(9)	1207021	14	12	14	6	4	1	3	5	1	0	0.726	1.000	1.000
34	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(9), PAPSS1(5), PAPSS2(7), SULT1A2(4), SULT1E1(6), SULT2A1(6), SUOX(5)	4786107	42	28	38	7	11	5	4	15	7	0	0.103	1.000	1.000
35	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(4), CTH(6), MUT(8)	3247633	27	22	27	6	10	1	7	4	5	0	0.160	1.000	1.000
36	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(6), ST6GALNAC4(4), ST8SIA1(10)	3762847	34	31	32	9	11	7	4	6	6	0	0.205	1.000	1.000
37	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), PGD(7)	11884235	168	107	144	31	35	31	25	50	27	0	0.000534	1.000	1.000
38	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	3264996	27	24	24	7	11	4	1	8	3	0	0.324	1.000	1.000
39	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(2), CSF1(5), CSF3(3), EPO(1), IL11(6), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), IL9(2)	4283263	56	43	52	16	19	11	6	15	4	1	0.180	1.000	1.000
40	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	GATA3(17), IL13(2), IL4(5), MAF(9), MAP2K3(11), MAPK14(8), NFATC2(12), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	6718345	99	76	94	29	41	21	6	17	14	0	0.0862	1.000	1.000
41	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(15), PDXK(1), PDXP(1), PNPO(2), PSAT1(7)	3361327	26	22	25	7	6	7	3	6	4	0	0.341	1.000	1.000
42	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(36), ACACB(40), MCAT(3), OLAH(10), OXSM(14)	8629635	103	67	91	18	31	16	17	19	19	1	0.00608	1.000	1.000
43	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(7), MMP2(18), MMP9(19), RECK(14), TIMP1(2), TIMP2(3), TIMP3(11), TIMP4(4)	5166574	82	60	78	22	41	13	6	14	8	0	0.0665	1.000	1.000
44	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(2), CCR3(11), CD4(4), HLA-DRB1(7), IL1B(5), IL4(5), IL5RA(11), IL6(7)	3331389	52	33	46	17	17	7	5	16	5	2	0.488	1.000	1.000
45	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	BGN(8), DCN(9), FMOD(8), KERA(9)	1998166	34	30	33	11	9	6	1	15	3	0	0.648	1.000	1.000
46	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(13), DLL1(10), FURIN(17), PSEN1(4)	3217820	44	34	44	13	16	6	5	8	9	0	0.223	1.000	1.000
47	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(6), IDI1(4), SQLE(2)	2105761	16	16	17	5	1	2	4	5	4	0	0.601	1.000	1.000
48	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(7), ACAA2(4), ACAT1(7), ACAT2(9), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), SDS(3)	5892793	71	60	65	20	14	14	13	16	14	0	0.162	1.000	1.000
49	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(4), EHHADH(15), HADHA(12), SDS(3)	3381529	34	31	30	11	8	5	7	6	8	0	0.423	1.000	1.000
50	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(2), COQ6(4), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1)	2825492	18	18	21	6	6	1	7	2	2	0	0.476	1.000	1.000
51	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(6), GGPS1(5), IDI1(4), IDI2(3), SQLE(2)	2887472	24	23	24	7	4	2	4	7	7	0	0.562	1.000	1.000
52	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	2	BMP1(17), BMPR1B(15)	2024102	32	27	31	10	11	5	2	7	7	0	0.647	1.000	1.000
53	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(7), ACOX1(11), ACOX3(10), ELOVL2(9), ELOVL5(3), ELOVL6(4), FADS2(12), HADHA(12), HSD17B12(3), SCD(4)	7469545	75	60	71	17	25	8	12	18	12	0	0.0305	1.000	1.000
54	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(5), CD4(4), CD80(6), HLA-DRB1(7), IL10(2), IL2(5), IL4(5)	2352651	34	23	32	11	8	4	5	10	5	2	0.588	1.000	1.000
55	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(14), CLOCK(24), CRY1(17), CRY2(5), CSNK1E(9), PER1(13)	5727864	82	56	60	17	21	13	4	22	20	2	0.164	1.000	1.000
56	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(12), ACO1(12), ACO2(7), ACSS1(7), ACSS2(10), FH(10), IDH2(17), MDH1(8), MDH2(3), SUCLA2(9)	8714026	95	76	86	24	23	19	12	27	14	0	0.0757	1.000	1.000
57	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(15), PARK2(14), SNCA(2), SNCAIP(8), UBE2E2(4), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5)	4435755	54	42	53	17	16	2	9	20	7	0	0.409	1.000	1.000
58	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(14), KARS(8)	3412261	27	24	25	8	4	4	6	8	5	0	0.534	1.000	1.000
59	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	C9orf47(2), CNR1(13), CNR2(1), DNMT1(28), MTNR1A(3), MTNR1B(15), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2)	6920622	88	64	80	23	41	10	7	18	12	0	0.0149	1.000	1.000
60	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(12), ACO2(7), FH(10), IDH2(17), MDH1(8), MDH2(3), SDHB(3), SUCLA2(9)	5673949	69	63	61	20	13	14	9	21	12	0	0.293	1.000	1.000
61	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(27), GNAS(39), GNB1(3), GNGT1(1), PRKACA(2), PRKAR1A(8)	3947776	80	70	61	24	41	18	3	13	5	0	0.199	1.000	1.000
62	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(4), GBA3(3), LPO(10), MPO(17), PRDX6(5), TPO(36)	5518266	89	69	82	22	43	12	8	14	12	0	0.0534	1.000	1.000
63	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(6), CDK7(3), MNAT1(4), SHH(3), XPO1(9)	6040819	62	50	60	15	16	12	8	21	5	0	0.138	1.000	1.000
64	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(5), DPM2(1), EGR1(14), HRAS(4), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NGFR(5), RAF1(16)	5086719	74	56	64	23	32	9	9	14	10	0	0.143	1.000	1.000
65	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9)	3892945	46	41	42	17	5	15	6	16	4	0	0.524	1.000	1.000
66	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(8), CBS(4), CTH(6), GGT1(11), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), PAPSS1(5), PAPSS2(7), SCLY(12), SEPHS1(7)	8333402	96	68	82	24	26	10	15	20	25	0	0.0927	1.000	1.000
67	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(27), DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10)	6120079	64	49	58	14	21	18	6	9	10	0	0.0624	1.000	1.000
68	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(1), GPD2(11), NDUFA1(2), SDHA(14), SDHB(3), SDHD(4), UQCRC1(4)	4494132	46	35	46	12	18	4	8	13	3	0	0.233	1.000	1.000
69	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(11), ACOX3(10), FADS2(12), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10)	7146239	74	54	70	18	30	11	8	15	10	0	0.0458	1.000	1.000
70	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), GBA3(3), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TPO(36), TYR(12)	6336993	104	78	95	28	48	17	10	17	12	0	0.0653	1.000	1.000
71	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), KARS(8)	5021396	52	44	47	15	8	9	10	16	9	0	0.422	1.000	1.000
72	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(11), CTH(6), GOT1(7), GOT2(2), LDHA(14), LDHB(8), LDHC(4)	4555695	52	44	44	14	16	13	6	10	7	0	0.237	1.000	1.000
73	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(12), ALAS2(12), CPO(10), FECH(4), GATA1(19), HBB(3), HMBS(5), UROD(3), UROS(5)	5728569	74	52	68	18	23	17	7	17	10	0	0.113	1.000	1.000
74	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), RAC1(2), WASF1(6), WASL(18)	5691919	72	48	69	20	21	9	11	19	12	0	0.202	1.000	1.000
75	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NFS1(6), PHPT1(2), THTPA(2), TPK1(10)	4460825	58	48	53	16	18	13	7	12	8	0	0.292	1.000	1.000
76	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(12), PON2(7), PON3(14), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	5765037	77	58	67	23	20	19	8	19	11	0	0.262	1.000	1.000
77	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(2), CTSD(6), ESR1(21), GREB1(29), HSPB2(3), MTA1(6), MTA3(4), PDZK1(2), TUBA8(5)	6286975	78	55	77	25	29	8	10	16	15	0	0.293	1.000	1.000
78	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(10), GNAQ(11), ITPKA(3), ITPKB(15)	3673735	44	37	41	15	15	9	3	11	6	0	0.476	1.000	1.000
79	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(10), FOS(5), JUN(2), MAPK3(4), OPRK1(14), POLR2A(14), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	8802767	87	71	83	22	34	15	5	15	18	0	0.0858	1.000	1.000
80	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(8), ANKRD1(9), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(13), IL18(3), IL1A(1), IL1R1(7), MYOG(6), NR4A3(9), WDR1(7)	7302242	70	45	69	16	20	14	9	18	9	0	0.0669	1.000	1.000
81	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), GSR(5), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), TXNDC12(3)	13338470	188	119	157	41	37	40	26	52	33	0	0.00354	1.000	1.000
82	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	8	CD3D(5), CD3E(2), CD4(4), FYN(17), HLA-DRB1(7), LCK(9), PTPRC(36), ZAP70(12)	5588107	92	72	79	28	21	19	14	16	20	2	0.250	1.000	1.000
83	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(11), CARS2(6), CDO1(3), CTH(6), GOT1(7), GOT2(2), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), SDS(3), SULT1B1(6), SULT1C2(6), SULT1C4(3), SULT4A1(6)	8615564	98	70	88	25	31	19	12	23	13	0	0.0897	1.000	1.000
84	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(3), GRB2(11), HBXIP(4), HRAS(4), PTK2B(13), SHC1(14), SOS1(16), SRC(3)	5976285	68	58	57	19	8	19	9	15	16	1	0.431	1.000	1.000
85	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GBA3(3), GGT1(11), SHMT1(7), SHMT2(5)	3523686	31	30	27	11	8	1	3	4	15	0	0.852	1.000	1.000
86	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	194	ABI2(5), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), APC(683), ARAF(10), ARHGEF1(15), ARHGEF12(12), ARHGEF4(9), ARHGEF6(19), ARHGEF7(23), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(4), BAIAP2(7), BCAR1(6), BDKRB1(4), BDKRB2(6), BRAF(125), CD14(6), CDC42(3), CFL1(2), CFL2(2), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CRKL(5), CSK(5), CYFIP1(16), CYFIP2(10), DIAPH1(7), DIAPH2(28), DIAPH3(19), DOCK1(24), EGF(8), EGFR(115), EZR(3), F2(10), F2R(11), FGD1(21), FGD3(16), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR4(12), FN1(58), GIT1(4), GNA12(7), GNA13(3), GRLF1(19), GSN(4), HRAS(4), IQGAP1(31), IQGAP2(32), IQGAP3(24), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LIMK1(8), LIMK2(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MOS(10), MRAS(4), MSN(9), MYH10(17), MYH14(25), MYH9(43), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), NCKAP1(17), NCKAP1L(25), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PFN2(4), PFN4(6), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R12B(33), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RDX(16), ROCK1(35), ROCK2(20), RRAS(2), RRAS2(7), SCIN(10), SLC9A1(12), SOS1(16), SOS2(17), SSH1(15), SSH2(16), SSH3(4), TIAM1(42), TIAM2(26), TMSL3(2), VAV1(24), VAV2(20), VAV3(30), VCL(10), WAS(4), WASF1(6), WASF2(5), WASL(18)	183473775	3565	472	2799	1224	719	877	427	754	620	168	0.0951	1.000	1.000
87	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	132	APC(683), AXIN1(10), AXIN2(27), BTRC(11), CACYBP(4), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(6), CHD8(37), CREBBP(81), CSNK1A1(3), CSNK1A1L(9), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(14), CTNNB1(120), CTNNBIP1(1), CUL1(17), CXXC4(2), DAAM1(10), DAAM2(20), DKK1(9), DKK2(27), DKK4(8), DVL2(12), DVL3(10), EP300(56), FBXW11(13), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LEF1(9), LRP5(11), LRP6(34), MAP3K7(9), MAPK10(18), MAPK8(17), MAPK9(13), MMP7(10), MYC(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NKD1(6), NLK(12), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRICKLE1(24), PRICKLE2(18), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PSEN1(4), RAC1(2), RAC2(1), RAC3(2), RBX1(1), ROCK1(35), ROCK2(20), RUVBL1(9), SENP2(4), SFRP1(3), SFRP2(10), SFRP4(9), SFRP5(1), SIAH1(2), SKP1(2), SMAD4(191), TBL1X(9), TBL1XR1(11), TCF7(15), TCF7L1(8), VANGL1(15), VANGL2(9), WIF1(5), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	98737262	2285	468	1741	748	489	532	234	408	459	163	0.0142	1.000	1.000
88	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(11), APC(683), AR(26), ASAH1(4), BRAF(125), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(10), EGFR(115), GNA11(8), GNA15(6), GNAI1(5), GNAQ(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), MAPK10(18), MAPK14(8), PHKA2(19), PIK3CA(344), PIK3CD(11), PIK3R1(62), PITX2(2), PTX3(3), RAF1(16), SRC(3)	35303546	1683	456	1080	552	197	528	201	305	295	157	0.0116	1.000	1.000
89	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(683), AXIN1(10), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), CTNNB1(120), DVL2(12), DVL3(10), FBXW2(6), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LDLR(11), MAPK10(18), MAPK9(13), MYC(5), PAFAH1B1(6), PLAU(7), PPP2R5C(6), PPP2R5E(8), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), RAC1(2), SFRP4(9), TCF7(15), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4)	36639766	1289	448	891	415	191	329	114	197	303	155	0.0294	1.000	1.000
90	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(11), APC(683), AXIN1(10), CCND1(2), CD14(6), CTNNB1(120), FZD1(9), GJA1(9), GNAI1(5), GSK3B(17), IRAK1(6), LBP(8), LEF1(9), LY96(4), MYD88(4), NFKB1(11), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), RELA(10), TIRAP(5), TLR4(18), TOLLIP(5), WNT1(7)	19556205	1372	444	810	433	107	470	170	193	275	157	7.66e-05	1.000	1.000
91	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT1(11), AKT2(8), AKT3(8), ANKRD6(12), APC(683), AXIN1(10), AXIN2(27), CER1(6), CSNK1A1(3), CTNNB1(120), DACT1(19), DKK1(9), DKK2(27), DKK3(9), DKK4(8), FSTL1(10), GSK3A(6), GSK3B(17), LRP1(53), MVP(10), NKD1(6), PIN1(2), PSEN1(4), PTPRA(6), SENP2(4), SFRP1(3), TSHB(2), WIF1(5)	26192383	1088	442	711	331	126	282	97	162	264	157	0.0141	1.000	1.000
92	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), BAD(1), BCAR1(6), BCL2(2), BIRC2(7), BIRC3(18), BRAF(125), CAPN2(10), CAV1(1), CAV2(4), CAV3(4), CCND1(2), CCND2(3), CCND3(2), CDC42(3), CHAD(10), COL11A1(65), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), CRKL(5), CTNNB1(120), DIAPH1(7), DOCK1(24), EGF(8), EGFR(115), ELK1(4), ERBB2(37), FARP2(13), FIGF(6), FLNA(31), FLNB(40), FLNC(39), FLT1(43), FN1(58), FYN(17), GRB2(11), GRLF1(19), GSK3B(17), HGF(17), HRAS(4), IBSP(6), IGF1(6), IGF1R(22), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), JUN(2), KDR(42), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), MAP2K1(12), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MET(55), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PDPK1(4), PGF(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PRKCA(8), PRKCG(24), PTEN(333), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF1(19), RELN(95), ROCK1(35), ROCK2(20), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SPP1(4), SRC(3), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TLN1(23), TLN2(17), TNC(41), TNN(33), TNR(48), VASP(4), VAV1(24), VAV2(20), VAV3(30), VCL(10), VEGFA(5), VEGFB(3), VEGFC(15), VTN(13), VWF(36), ZYX(5)	238284017	4202	440	3518	1638	1012	1113	559	972	522	24	0.700	1.000	1.000
93	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	28	ACVR1(9), APC(683), ATF2(7), AXIN1(10), BMP10(15), BMP2(9), BMP4(6), BMP5(9), BMP7(15), CHRD(16), CTNNB1(120), FZD1(9), GATA4(4), GSK3B(17), MAP3K7(9), MEF2C(15), MYL2(2), NPPA(1), NPPB(5), RFC1(25), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), WNT1(7)	21480701	1070	434	699	324	120	274	95	170	256	155	0.00169	1.000	1.000
94	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(683), AXIN1(10), CREBBP(81), CTNNB1(120), EP300(56), FZD1(9), GSK3B(17), HDAC1(5), LDB1(9), LEF1(9), PITX2(2), TRRAP(70), WNT1(7)	22125437	1078	434	690	342	105	309	101	145	263	155	0.00516	1.000	1.000
95	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(683), AXIN1(10), BTRC(11), CCND1(2), CREBBP(81), CSNK1A1(3), CSNK1D(15), CSNK2A1(7), CTBP1(5), CTNNB1(120), FZD1(9), GSK3B(17), HDAC1(5), MAP3K7(9), MYC(5), NLK(12), PPARD(5), PPP2CA(3), TLE1(7), WIF1(5), WNT1(7)	19002093	1021	432	648	321	81	278	102	149	256	155	0.00606	1.000	1.000
96	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(4), AKT1(11), APC(683), ASAH1(4), CAMP(1), CAV3(4), DAG1(10), DLG4(10), EPHB2(16), GNAI1(5), GNAQ(11), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(5), RYR1(70)	30404752	1010	430	708	325	153	220	91	146	244	156	0.0508	1.000	1.000
97	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(683), CREBBP(81), EP300(56), MAP2K1(12), MAP3K7(9), MAPK3(4), SKIL(9), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26)	16968923	914	425	580	283	85	241	76	115	243	154	0.00645	1.000	1.000
98	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	164	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY7(13), ADCY8(34), ADCY9(22), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), ATP2A1(24), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), ATP2B4(26), AVPR1A(15), AVPR1B(5), BDKRB1(4), BDKRB2(6), BST1(3), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CCKAR(9), CCKBR(16), CD38(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM5(6), CHRNA7(1), CYSLTR1(9), CYSLTR2(18), DRD1(9), EDNRA(9), EDNRB(19), EGFR(115), ERBB2(37), ERBB3(32), ERBB4(65), F2R(11), GNA11(8), GNA14(13), GNA15(6), GNAL(5), GNAQ(11), GNAS(39), GRIN1(5), GRIN2A(55), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), GRPR(4), HRH1(4), HRH2(16), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), LHCGR(27), MYLK(33), MYLK2(10), NOS1(31), NOS3(23), NTSR1(5), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), PDE1A(10), PDE1B(11), PDE1C(19), PDGFRA(64), PDGFRB(21), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PLN(1), PPID(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTAFR(1), PTGFR(8), PTK2B(13), RYR1(70), RYR2(138), RYR3(84), SLC25A4(4), SLC25A5(10), SLC8A1(24), SLC8A2(16), SLC8A3(17), SPHK1(3), SPHK2(5), TACR1(9), TACR2(4), TACR3(18), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(17), VDAC1(6), VDAC2(4), VDAC3(2)	172482049	2744	424	2576	1007	951	533	300	597	352	11	0.267	1.000	1.000
99	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(13), APC(683), AXIN1(10), BTRC(11), CTNNB1(120), DLL1(10), FZD1(9), GSK3B(17), PSEN1(4), WNT1(7)	10915034	884	422	528	263	46	245	78	124	236	155	0.000515	1.000	1.000
100	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	22	APC(683), ASAH1(4), CAMP(1), CASP3(4), CERK(3), CREB1(3), CREB3(6), CREB5(8), DAG1(10), EPHB2(16), FOS(5), GNAQ(11), ITPKA(3), ITPKB(15), JUN(2), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13)	16815728	843	419	538	243	61	205	67	119	237	154	0.00106	1.000	1.000
101	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	219	ADCYAP1R1(5), ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), ADRA1A(12), ADRA1B(6), ADRA2A(5), ADRA2B(7), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), C5AR1(8), CALCR(12), CALCRL(9), CCKAR(9), CCKBR(16), CGA(3), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CNR1(13), CNR2(1), CRHR1(6), CRHR2(6), CTSG(5), CYSLTR1(9), CYSLTR2(18), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2(10), F2R(11), F2RL1(8), F2RL2(8), FPR1(8), FSHB(6), FSHR(19), GABBR1(20), GABBR2(23), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GABRB1(11), GABRB2(10), GABRB3(19), GABRD(6), GABRE(12), GABRG1(21), GABRG2(20), GABRG3(12), GABRP(13), GABRQ(19), GABRR1(5), GABRR2(8), GALR1(5), GH1(5), GH2(6), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(11), GLP2R(10), GLRA1(10), GLRA2(9), GLRA3(13), GLRB(14), GNRHR(9), GPR156(17), GPR35(3), GPR50(9), GPR63(7), GPR83(7), GRIA1(38), GRIA2(29), GRIA3(15), GRIA4(46), GRID1(30), GRID2(28), GRIK1(13), GRIK2(49), GRIK3(33), GRIK4(21), GRIK5(15), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRIN3A(19), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM6(27), GRM7(36), GRM8(29), GRPR(4), GZMA(11), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HRH4(6), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LEP(1), LEPR(21), LHB(3), LHCGR(27), LTB4R(2), MAS1(3), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), MCHR1(8), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPBWR1(7), NPBWR2(1), NPFFR1(1), NPFFR2(14), NPY1R(6), NPY2R(12), NPY5R(7), NR3C1(11), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), P2RY1(8), P2RY10(15), P2RY14(11), P2RY2(8), P2RY4(8), P2RY6(6), PARD3(13), PPYR1(8), PRL(4), PRLHR(5), PRLR(10), PRSS1(7), PRSS3(6), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTH2R(16), RXFP1(7), RXFP2(21), SCTR(6), SSTR1(12), SSTR2(6), SSTR4(14), TAAR1(7), TAAR2(7), TAAR5(10), TAAR6(7), TAAR8(6), TAAR9(6), TACR1(9), TACR2(4), TACR3(18), THRA(6), THRB(14), TRHR(9), TRPV1(11), TSHB(2), VIPR1(7), VIPR2(11)	140494298	2484	418	2247	909	870	436	275	605	293	5	0.0629	1.000	1.000
102	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	134	ACTB(4), ACTG1(6), CHAD(10), COL11A1(65), COL11A2(19), COL17A1(16), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), DES(6), DSC1(14), DSC2(17), DSC3(13), DSG1(23), DSG2(12), DSG3(17), DSG4(29), FN1(58), GJA1(9), GJA10(17), GJA3(5), GJA4(3), GJA5(7), GJA8(22), GJA9(6), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GJB7(4), GJC1(10), GJC3(4), GJD2(5), GJD4(4), IBSP(6), INA(9), ITGA6(16), ITGB4(18), KRT1(19), KRT10(7), KRT12(7), KRT13(11), KRT14(10), KRT15(9), KRT16(5), KRT17(11), KRT18(3), KRT19(4), KRT2(15), KRT20(3), KRT23(9), KRT24(5), KRT25(12), KRT27(3), KRT28(5), KRT3(13), KRT31(12), KRT32(7), KRT33A(8), KRT33B(6), KRT34(11), KRT35(7), KRT36(5), KRT37(11), KRT38(3), KRT39(9), KRT4(36), KRT40(2), KRT5(8), KRT6A(8), KRT6B(6), KRT6C(7), KRT7(6), KRT71(9), KRT72(14), KRT73(14), KRT74(9), KRT75(14), KRT76(9), KRT77(6), KRT78(6), KRT79(8), KRT8(4), KRT81(3), KRT82(7), KRT83(4), KRT84(12), KRT85(15), KRT86(4), KRT9(13), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), LMNA(1), LMNB1(11), LMNB2(3), NES(30), PRPH(3), RELN(95), SPP1(4), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VIM(9), VTN(13), VWF(36)	159764754	2186	396	2023	863	762	314	297	497	313	3	0.856	1.000	1.000
103	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	234	ACVR1C(11), AKT1(11), AKT2(8), AKT3(8), ARRB1(4), ARRB2(1), ATF2(7), ATF4(4), BDNF(5), BRAF(125), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CACNA2D1(31), CACNA2D2(9), CACNA2D3(24), CACNA2D4(13), CACNB1(6), CACNB2(11), CACNB3(3), CACNB4(4), CACNG1(5), CACNG2(6), CACNG3(12), CACNG4(4), CACNG5(9), CACNG6(4), CACNG7(9), CACNG8(2), CASP3(4), CD14(6), CDC25B(11), CDC42(3), CHUK(27), CRKL(5), DAXX(18), DDIT3(5), DUSP1(7), DUSP10(6), DUSP16(11), DUSP3(4), DUSP4(6), DUSP5(2), DUSP6(7), DUSP7(8), DUSP9(9), ECSIT(7), EGF(8), EGFR(115), ELK1(4), ELK4(5), FAS(9), FASLG(3), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR4(12), FLNA(31), FLNB(40), FLNC(39), FOS(5), GADD45G(1), GNA12(7), GRB2(11), HRAS(4), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAPT(11), MAX(5), MEF2C(15), MKNK1(4), MKNK2(7), MOS(10), MRAS(4), MYC(5), NF1(138), NFATC2(12), NFATC4(12), NFKB1(11), NFKB2(6), NLK(12), NR4A1(3), NTF3(3), NTRK1(17), NTRK2(25), PAK1(11), PAK2(15), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PPM1A(9), PPM1B(6), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PPP5C(9), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTPN5(8), PTPN7(4), PTPRR(16), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF2(35), RASA1(24), RASA2(17), RASGRF1(25), RASGRF2(26), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KA6(18), RRAS(2), RRAS2(7), SOS1(16), SOS2(17), SRF(4), STK3(8), STK4(9), STMN1(2), TAOK1(17), TAOK2(14), TAOK3(20), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF1A(4), TRAF2(8), TRAF6(4), ZAK(12)	181328728	2748	389	2458	934	790	599	311	630	403	15	0.0265	1.000	1.000
104	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(31), ABL2(20), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BRAF(125), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CBL(45), CBLB(17), CBLC(3), CDKN1A(2), CDKN1B(6), CRKL(5), EGF(8), EGFR(115), ELK1(4), ERBB2(37), ERBB3(32), ERBB4(65), EREG(3), GAB1(15), GRB2(11), GSK3B(17), HBEGF(1), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYC(5), NCK1(1), NCK2(5), NRG1(33), NRG2(8), NRG3(18), NRG4(2), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), RAF1(16), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SRC(3), STAT5A(10), STAT5B(20)	68063061	1569	373	1174	564	288	507	239	333	199	3	0.309	1.000	1.000
105	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	CD36(3), CD44(6), CD47(8), CHAD(10), COL11A1(65), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), DAG1(10), FN1(58), FNDC1(44), FNDC3A(15), FNDC4(6), FNDC5(2), GP5(9), GP6(13), GP9(1), HMMR(17), HSPG2(27), IBSP(6), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), RELN(95), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SPP1(4), SV2A(24), SV2B(11), SV2C(13), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VTN(13), VWF(36)	143247103	1883	372	1774	762	628	277	248	456	268	6	0.888	1.000	1.000
106	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(21), ATP1B1(4), ATP1B2(4), ATP1B3(4), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1S(34), CACNB1(6), CACNB3(3), CALM2(1), CALM3(1), CALR(2), CAMK1(9), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CASQ1(5), CASQ2(11), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), GJA1(9), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), ITPR1(43), ITPR2(49), ITPR3(44), KCNB1(22), KCNJ3(11), KCNJ5(11), MIB1(13), MYCBP(1), NME7(9), PEA15(1), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLN(1), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SLC8A3(17), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1)	122428045	1734	364	1694	642	642	271	191	371	250	9	0.311	1.000	1.000
107	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	125	ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), AMOTL1(15), ASH1L(64), CASK(11), CDC42(3), CDK4(4), CGN(18), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTTN(5), EPB41(11), EPB41L1(14), EPB41L2(12), EPB41L3(35), EXOC3(3), EXOC4(22), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), HCLS1(16), HRAS(4), IGSF5(16), INADL(18), JAM2(2), JAM3(9), LLGL1(7), LLGL2(8), MAGI1(31), MAGI2(32), MAGI3(10), MLLT4(21), MPDZ(26), MPP5(7), MRAS(4), MYH1(47), MYH10(17), MYH11(49), MYH13(28), MYH14(25), MYH15(37), MYH2(42), MYH3(46), MYH4(30), MYH6(34), MYH7(28), MYH7B(31), MYH8(47), MYH9(43), MYL2(2), MYL7(1), MYL9(3), OCLN(2), PARD3(13), PARD6A(2), PARD6B(2), PARD6G(7), PPM1J(3), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP2R3A(16), PPP2R4(4), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PTEN(333), RAB13(1), RAB3B(3), RRAS(2), RRAS2(7), SPTAN1(30), SRC(3), SYMPK(11), TJAP1(5), TJP1(25), TJP2(17), TJP3(12), VAPA(2), YES1(10), ZAK(12)	128194095	2031	364	1731	716	567	508	246	423	269	18	0.302	1.000	1.000
108	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	143	AKT1(11), AKT2(8), AKT3(8), BCL2L1(1), CBL(45), CBLB(17), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(81), CSF2RB(13), CSF3(3), CSF3R(19), EP300(56), EPO(1), EPOR(2), GH1(5), GH2(6), GHR(12), GRB2(11), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL13RA2(17), IL15(1), IL15RA(1), IL19(3), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL9(2), IRF9(6), JAK1(22), JAK2(55), JAK3(31), LEP(1), LEPR(21), LIF(1), LIFR(41), MPL(9), MYC(5), OSM(4), OSMR(22), PIAS1(4), PIAS2(5), PIAS3(10), PIAS4(2), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIM1(4), PRL(4), PRLR(10), PTPN11(41), PTPN6(4), SOCS2(4), SOCS4(1), SOCS5(12), SOCS7(1), SOS1(16), SOS2(17), SPRED1(10), SPRED2(10), SPRY1(10), SPRY2(2), SPRY4(7), STAM(4), STAM2(4), STAT1(17), STAT2(12), STAT3(10), STAT4(13), STAT5A(10), STAT5B(20), STAT6(4), TPO(36), TSLP(3), TYK2(5)	96589797	1667	363	1312	583	338	488	239	385	209	8	0.139	1.000	1.000
109	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	103	ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), BCAR1(6), CDC42(3), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTNND1(19), CXCL12(2), CXCR4(7), CYBB(6), ESAM(6), EZR(3), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), GRLF1(19), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), ITK(26), JAM2(2), JAM3(9), MAPK12(4), MAPK13(6), MAPK14(8), MLLT4(21), MMP2(18), MMP9(19), MSN(9), MYL2(2), MYL7(1), MYL9(3), NCF1(4), NCF2(10), NCF4(5), NOX1(4), NOX3(14), OCLN(2), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAC1(2), RAC2(1), RAP1A(2), RAP1B(2), RAPGEF3(8), RAPGEF4(12), RASSF5(6), RHOH(5), ROCK1(35), ROCK2(20), SIPA1(10), TXK(12), VASP(4), VAV1(24), VAV2(20), VAV3(30), VCAM1(15), VCL(10)	79255893	1536	362	1210	566	358	434	203	339	195	7	0.606	1.000	1.000
110	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	235	ACVR1(9), ACVR2B(14), AMHR2(4), BMP2(9), BMP7(15), BMPR1B(15), CCL11(2), CCL13(1), CCL14(4), CCL15(2), CCL16(2), CCL17(1), CCL18(2), CCL22(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL28(4), CCL4(1), CCL7(2), CCL8(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CD27(4), CD40(7), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(5), CSF1R(16), CSF2RB(13), CSF3(3), CSF3R(19), CX3CL1(5), CX3CR1(6), CXCL1(1), CXCL10(2), CXCL11(4), CXCL12(2), CXCL14(2), CXCL16(3), CXCL5(6), CXCL6(1), CXCL9(7), CXCR3(5), CXCR4(7), CXCR6(1), EDA(5), EDA2R(4), EDAR(8), EGF(8), EGFR(115), EPO(1), EPOR(2), FAS(9), FASLG(3), FLT1(43), FLT3(36), FLT3LG(1), FLT4(18), GDF5(13), GH1(5), GH2(6), GHR(12), HGF(17), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL15(1), IL15RA(1), IL17A(3), IL17B(1), IL17RA(8), IL17RB(8), IL18(3), IL18R1(16), IL18RAP(12), IL19(3), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL1RAP(7), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL25(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL8(6), IL9(2), INHBA(21), INHBB(3), INHBC(4), INHBE(3), KDR(42), KIT(161), KITLG(3), LEP(1), LEPR(21), LIF(1), LIFR(41), LTA(1), LTBR(5), MET(55), MPL(9), NGFR(5), OSM(4), OSMR(22), PDGFB(2), PDGFC(10), PDGFRA(64), PDGFRB(21), PF4(3), PLEKHO2(7), PPBP(6), PRL(4), PRLR(10), RELT(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFRSF11A(6), TNFRSF11B(7), TNFRSF13B(7), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFRSF8(8), TNFRSF9(10), TNFSF10(3), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(4), TNFSF14(4), TNFSF15(3), TNFSF4(6), TNFSF8(6), TPO(36), TSLP(3), VEGFA(5), VEGFB(3), VEGFC(15), XCL1(1), XCL2(4), XCR1(6)	114579528	1828	361	1619	646	445	460	220	463	235	5	0.136	1.000	1.000
111	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	123	ACACA(36), ACACB(40), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BRAF(125), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBL(45), CBLB(17), CBLC(3), CRKL(5), ELK1(4), EXOC7(4), FBP1(1), FBP2(5), FLOT1(7), FLOT2(2), FOXO1(8), G6PC(5), G6PC2(3), GCK(6), GRB2(11), GSK3B(17), GYS1(6), GYS2(17), HRAS(4), IKBKB(9), INPP5D(10), INSR(21), IRS1(21), IRS4(36), LIPE(11), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MKNK1(4), MKNK2(7), PCK1(6), PCK2(6), PDE3A(21), PDE3B(10), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PKLR(12), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R3A(45), PPP1R3B(4), PPP1R3C(6), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACA(2), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCI(25), PRKCZ(4), PRKX(3), PTPN1(11), PTPRF(23), PYGB(15), PYGL(8), PYGM(12), RAF1(16), RAPGEF1(19), RHEB(5), RHOQ(6), RPS6(3), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SLC2A4(8), SOCS2(4), SOCS4(1), SORBS1(15), SOS1(16), SOS2(17), SREBF1(8), TRIP10(5), TSC1(18), TSC2(17)	101810232	1716	360	1348	594	405	456	243	394	214	4	0.0627	1.000	1.000
112	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS1(15), CDS2(10), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), FN3K(1), IMPA1(4), IMPA2(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5D(10), INPP5E(3), INPPL1(16), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), OCRL(21), PI4KA(29), PI4KB(5), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3C3(29), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PRKCA(8), PRKCG(24), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15)	81870157	1678	358	1286	603	344	559	231	329	203	12	0.396	1.000	1.000
113	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(31), ACTN1(13), ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGEF6(19), ARHGEF7(23), BCAR1(6), BRAF(125), CAV1(1), CDC42(3), CDKN2A(9), CSE1L(10), DOCK1(24), EPHB2(16), FYN(17), GRB2(11), GRB7(3), GRLF1(19), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGB3BP(3), MAP3K11(12), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MRAS(4), MYLK(33), MYLK2(10), P4HB(6), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CA(344), PIK3CB(6), PKLR(12), PLCG1(19), PLCG2(28), PTEN(333), PTK2(24), RAF1(16), RALA(8), RHO(5), ROCK1(35), ROCK2(20), SHC1(14), SOS1(16), SOS2(17), SRC(3), TERF2IP(4), TLN1(23), TLN2(17), VASP(4), WAS(4), ZYX(5)	80363437	1735	357	1295	654	279	565	251	394	231	15	0.666	1.000	1.000
114	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	121	ABL1(31), ABLIM1(11), ABLIM2(7), ABLIM3(17), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CFL2(2), CXCL12(2), CXCR4(7), DCC(42), DPYSL2(11), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(6), EFNB1(6), EFNB2(1), EFNB3(11), EPHA1(11), EPHA2(12), EPHA3(70), EPHA4(26), EPHA5(47), EPHA6(28), EPHA7(45), EPHA8(19), EPHB1(38), EPHB2(16), EPHB3(12), EPHB4(15), EPHB6(15), FES(7), FYN(17), GNAI1(5), GNAI2(2), GNAI3(2), GSK3B(17), HRAS(4), ITGB1(13), L1CAM(17), LIMK1(8), LIMK2(13), LRRC4C(17), MAPK1(3), MAPK3(4), MET(55), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NGEF(19), NRP1(12), NTN1(5), NTN4(10), NTNG1(17), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLXNA1(22), PLXNA2(26), PLXNA3(24), PLXNB1(22), PLXNB2(28), PLXNB3(25), PLXNC1(20), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RAC3(2), RASA1(24), RGS3(25), RND1(3), ROBO1(32), ROBO3(12), ROCK1(35), ROCK2(20), SEMA3A(21), SEMA3B(7), SEMA3C(18), SEMA3D(29), SEMA3E(22), SEMA3F(13), SEMA3G(10), SEMA4A(13), SEMA4B(5), SEMA4C(5), SEMA4D(18), SEMA4F(14), SEMA4G(11), SEMA5A(21), SEMA5B(26), SEMA6A(9), SEMA6B(8), SEMA6C(13), SEMA6D(15), SEMA7A(3), SLIT1(31), SLIT2(33), SLIT3(25), SRGAP1(25), SRGAP2(9), SRGAP3(21), UNC5A(9), UNC5B(10), UNC5C(17), UNC5D(22)	120612345	1785	354	1652	649	585	335	192	393	272	8	0.490	1.000	1.000
115	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	118	ARAF(10), BID(2), BRAF(125), CASP3(4), CD244(7), CD247(3), CD48(2), FAS(9), FASLG(3), FCGR3A(5), FCGR3B(2), FYN(17), GRB2(11), GZMB(5), HCST(2), HLA-C(13), HLA-E(4), HLA-G(13), HRAS(4), ICAM1(4), ICAM2(6), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), ITGAL(21), ITGB2(18), KIR2DL1(10), KIR2DL4(5), KIR3DL1(10), KIR3DL2(7), KLRC1(2), KLRC2(2), KLRC3(8), KLRD1(3), KLRK1(8), LAT(3), LCK(9), LCP2(10), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MICB(4), NCR1(3), NCR2(2), NCR3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), PAK1(11), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRF1(8), PRKCA(8), PRKCG(24), PTK2B(13), PTPN11(41), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SH2D1A(3), SH2D1B(1), SH3BP2(7), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SYK(8), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFSF10(3), TYROBP(1), ULBP1(7), ULBP2(2), ULBP3(6), VAV1(24), VAV2(20), VAV3(30), ZAP70(12)	72971449	1429	351	1054	501	291	423	197	328	186	4	0.169	1.000	1.000
116	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(14), ACTA2(3), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADM(5), ARRB1(4), ARRB2(1), ATF1(6), ATF2(7), ATF3(1), ATF4(4), ATF5(2), ATP2A2(17), ATP2A3(13), CACNB3(3), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CNN1(5), CNN2(4), CORIN(21), CREB3(6), CRHR1(6), DGKZ(9), ETS2(5), FOS(5), GABPA(14), GABPB2(4), GBA2(15), GJA1(9), GNAQ(11), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), GSTO1(2), GUCA2B(3), GUCY1A3(33), IGFBP1(2), IGFBP2(3), IGFBP3(8), IGFBP4(4), IGFBP6(2), IL1B(5), IL6(7), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), MIB1(13), MYL2(2), MYL4(4), MYLK2(10), NFKB1(11), NOS1(31), NOS3(23), OXTR(3), PDE4B(13), PDE4D(9), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLCD1(10), PLCG1(19), PLCG2(28), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RAMP1(2), RAMP2(2), RAMP3(7), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RLN1(4), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SP1(7), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1)	108292599	1512	351	1467	517	519	233	188	342	224	6	0.0410	1.000	1.000
117	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA1(14), ACTA2(3), ACTN2(19), ACTN3(6), ACTN4(8), DES(6), DMD(85), FAM48A(13), MYBPC1(12), MYBPC2(16), MYBPC3(15), MYH3(46), MYH6(34), MYH7(28), MYH8(47), MYL2(2), MYL3(1), MYL4(4), MYL9(3), MYOM1(35), NEB(106), TMOD1(8), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(3), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(8), TPM3(7), TPM4(9), TTN(882), VIM(9)	80510551	1450	350	1322	421	406	293	195	423	114	19	3.55e-05	1.000	1.000
118	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	69	ACP1(5), ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), ACVR1C(11), BAIAP2(7), CDC42(3), CREBBP(81), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTNND1(19), EGFR(115), EP300(56), ERBB2(37), FARP2(13), FER(18), FGFR1(22), FYN(17), IGF1R(22), INSR(21), IQGAP1(31), LEF1(9), LMO7(33), MAP3K7(9), MAPK1(3), MAPK3(4), MET(55), MLLT4(21), NLK(12), PARD3(13), PTPN1(11), PTPN6(4), PTPRB(21), PTPRF(23), PTPRJ(18), PTPRM(48), PVRL1(9), PVRL2(5), PVRL3(5), PVRL4(11), RAC1(2), RAC2(1), RAC3(2), SMAD4(191), SNAI1(6), SNAI2(11), SORBS1(15), SRC(3), SSX2IP(9), TCF7(15), TCF7L1(8), TGFBR1(20), TGFBR2(26), TJP1(25), VCL(10), WAS(4), WASF1(6), WASF2(5), WASF3(17), WASL(18), YES1(10)	76674455	1482	346	1226	522	349	413	186	325	204	5	0.161	1.000	1.000
119	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRB1(4), CSNK1D(15), DRD1(9), DRD2(9), EGF(8), EGFR(115), GJA1(9), GJD2(5), GNA11(8), GNAI1(5), GNAI2(2), GNAI3(2), GNAQ(11), GNAS(39), GRB2(11), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), HTR2A(24), HTR2B(7), HTR2C(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAP2K5(6), MAP3K2(9), MAPK1(3), MAPK3(4), MAPK7(6), NPR1(18), NPR2(17), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), PRKX(3), RAF1(16), SOS1(16), SOS2(17), SRC(3), TJP1(25), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10)	86835430	1383	346	1256	505	446	292	179	315	147	4	0.203	1.000	1.000
120	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT1(11), AKT2(8), AKT3(8), BCL10(8), CARD11(59), CBL(45), CBLB(17), CBLC(3), CD247(3), CD28(5), CD3D(5), CD3E(2), CD4(4), CD40LG(10), CD8A(2), CD8B(4), CDC42(3), CDK4(4), CHUK(27), CTLA4(5), FOS(5), FYN(17), GRAP2(7), GRB2(11), HRAS(4), ICOS(2), IFNG(3), IKBKB(9), IKBKG(2), IL10(2), IL2(5), IL4(5), ITK(26), JUN(2), LAT(3), LCK(9), LCP2(10), MALT1(13), MAP3K14(6), MAP3K8(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDCD1(2), PDK1(7), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCQ(16), PTPN6(4), PTPRC(36), RASGRP1(8), SOS1(16), SOS2(17), TEC(10), TNF(2), VAV1(24), VAV2(20), VAV3(30), ZAP70(12)	66195292	1270	346	983	427	271	401	189	246	161	2	0.0168	1.000	1.000
121	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	78	ACVR1(9), ACVRL1(8), AKT1(11), AURKB(6), BUB1(16), CDKL1(6), CDKL2(16), CDS1(15), CDS2(10), CLK1(10), CLK2(3), CLK4(17), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), IMPA1(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MAP3K10(11), MOS(10), NEK1(20), NEK3(10), OCRL(21), PAK4(6), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CA(344), PIK3CB(6), PIK3CG(41), PIM2(1), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28), PLK3(3), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKG1(18), RAF1(16), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KB1(9), STK11(38), TGFBR1(20), VRK1(7)	72321135	1325	345	1030	465	327	370	195	267	164	2	0.284	1.000	1.000
122	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(31), ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), ATM(237), ATR(53), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDC14A(14), CDC14B(6), CDC16(6), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(6), CDC26(1), CDC27(21), CDC6(10), CDC7(25), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CHEK1(11), CHEK2(30), CREBBP(81), CUL1(17), DBF4(11), E2F2(7), E2F3(6), EP300(56), ESPL1(23), FZR1(4), GADD45G(1), GSK3B(17), HDAC1(5), HDAC2(8), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTTG1(2), RB1(139), RBL1(21), RBL2(24), RBX1(1), SFN(1), SKP1(2), SKP2(3), SMAD4(191), SMC1A(21), SMC1B(28), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), WEE1(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	91130046	1600	342	1276	559	305	476	156	365	275	23	0.453	1.000	1.000
123	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2L1(1), CDC42(3), CDK2(5), CDKN1B(6), CDKN2A(9), CREB1(3), CREB3(6), CREB5(8), EBP(6), ERBB4(65), F2RL2(8), GAB1(15), GRB2(11), GSK3A(6), GSK3B(17), IGF1(6), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), MET(55), MYC(5), NOLC1(9), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARD3(13), PARD6A(2), PDK1(7), PIK3CA(344), PIK3CD(11), PPP1R13B(10), PREX1(27), PTEN(333), PTK2(24), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SLC2A4(8), SOS1(16), SOS2(17), TSC1(18), TSC2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	49803085	1380	341	1000	517	203	511	220	271	166	9	0.458	1.000	1.000
124	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	150	ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCBP2(14), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CCRL1(7), CCRL2(5), CHML(25), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CMKLR1(8), CNR1(13), CNR2(1), CX3CR1(6), CXCR3(5), CXCR4(7), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2R(11), F2RL1(8), F2RL2(8), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GPR17(3), GPR173(3), GPR174(10), GPR3(3), GPR35(3), GPR37(15), GPR37L1(8), GPR4(7), GPR44(2), GPR50(9), GPR6(8), GPR63(7), GPR77(4), GPR83(7), GPR85(7), GPR87(12), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LHCGR(27), LTB4R(2), MAS1(3), MC1R(2), MC3R(14), MC4R(7), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPN1SW(8), OPN3(7), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OR10A5(3), OR12D3(4), OR1C1(11), OR1F1(4), OR1Q1(5), OR2H1(5), OR7A5(6), OR8B8(6), OXTR(3), P2RY1(8), P2RY10(15), P2RY12(6), P2RY14(11), P2RY2(8), P2RY6(6), PPYR1(8), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), RGR(4), RHO(5), RRH(7), SSTR1(12), SSTR2(6), SSTR4(14), SUCNR1(6), TRHR(9)	75078166	1257	337	1134	466	457	236	154	290	119	1	0.0173	1.000	1.000
125	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(31), ATM(237), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDAN1(9), CDC14A(14), CDC14B(6), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(6), CDC6(10), CDC7(25), CDK2(5), CDK4(4), CDKN1A(2), CDKN2A(9), CHEK1(11), CHEK2(30), DTX4(8), E2F2(7), E2F3(6), E2F4(2), E2F5(6), E2F6(4), EP300(56), ESPL1(23), GSK3B(17), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), HDAC8(3), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MPEG1(8), MPL(9), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTPRA(6), PTTG1(2), RB1(139), RBL1(21), SKP2(3), SMAD4(191), TBC1D8(11), TFDP1(10), TGFB1(2), WEE1(15)	73522047	1336	334	1046	477	242	428	134	298	214	20	0.494	1.000	1.000
126	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(13), AKT1(11), AKT2(8), AKT3(8), APAF1(27), ATM(237), BAD(1), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CAPN1(2), CAPN2(10), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CSF2RB(13), CYCS(1), DFFA(6), DFFB(2), ENDOG(3), FADD(1), FAS(9), FASLG(3), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL3(6), IRAK1(6), IRAK2(11), IRAK3(11), IRAK4(8), MAP3K14(6), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), NTRK1(17), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), RIPK1(7), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFRSF1A(4), TNFSF10(3), TRAF2(8)	55594231	1197	333	874	427	207	398	161	246	174	11	0.401	1.000	1.000
127	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	118	ALCAM(12), CADM1(18), CADM3(15), CD2(7), CD22(17), CD226(6), CD274(5), CD276(6), CD28(5), CD34(7), CD4(4), CD40(7), CD40LG(10), CD6(6), CD80(6), CD86(2), CD8A(2), CD8B(4), CDH15(3), CDH2(40), CDH3(9), CDH4(24), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CNTN1(31), CNTN2(13), CNTNAP1(15), CNTNAP2(39), CTLA4(5), ESAM(6), F11R(4), GLG1(15), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), ICAM1(4), ICAM2(6), ICAM3(3), ICOS(2), ICOSLG(5), ITGA4(20), ITGA6(16), ITGA8(20), ITGA9(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGB1(13), ITGB2(18), ITGB7(10), ITGB8(12), JAM2(2), JAM3(9), L1CAM(17), MAG(11), MPZ(2), MPZL1(7), NCAM1(18), NCAM2(29), NEGR1(4), NEO1(14), NFASC(41), NLGN1(21), NLGN2(5), NLGN3(11), NRCAM(21), NRXN1(46), NRXN2(24), NRXN3(35), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(36), PTPRF(23), PTPRM(48), PVR(2), PVRL1(9), PVRL2(5), PVRL3(5), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SELE(13), SELL(5), SELP(15), SIGLEC1(19), SPN(6), VCAM1(15), VCAN(74)	92717775	1317	332	1242	511	403	192	158	351	208	5	0.742	1.000	1.000
128	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGAP1(3), ARHGAP4(7), ARHGEF11(24), BTK(12), CDC42(3), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(16), ITPR1(43), ITPR2(49), ITPR3(44), LIMK1(8), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3CG(41), PIK3R1(62), PITX2(2), PPP1R13B(10), PTEN(333), RACGAP1(5), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), SAG(5), WASF1(6), WASL(18)	46398755	1297	332	941	475	196	475	195	253	163	15	0.488	1.000	1.000
129	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	94	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), CREB3(6), CREB3L1(6), CREB3L2(5), CREB3L3(7), CREB3L4(5), CREBBP(81), CTNNB1(120), DCT(22), DVL2(12), DVL3(10), EDN1(3), EDNRB(19), EP300(56), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAS(39), GSK3B(17), HRAS(4), KIT(161), KITLG(3), LEF1(9), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MC1R(2), MITF(19), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), POMC(4), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAF1(16), TCF7(15), TCF7L1(8), TYR(12), TYRP1(6), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	68254110	1271	330	1085	499	396	335	154	242	144	0	0.656	1.000	1.000
130	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(11), AKT2(8), AKT3(8), CASP8(20), CCL4(1), CD14(6), CD40(7), CD80(6), CD86(2), CHUK(27), CXCL10(2), CXCL11(4), CXCL9(7), FADD(1), FOS(5), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IKBKB(9), IKBKE(9), IKBKG(2), IL12A(2), IL12B(1), IL1B(5), IL6(7), IL8(6), IRAK1(6), IRAK4(8), IRF3(4), IRF5(6), JUN(2), LBP(8), LY96(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K7(9), MAP3K8(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), RAC1(2), RELA(10), RIPK1(7), SPP1(4), STAT1(17), TBK1(12), TICAM1(15), TIRAP(5), TLR1(11), TLR2(12), TLR3(15), TLR4(18), TLR5(9), TLR6(14), TLR7(18), TLR8(20), TLR9(16), TNF(2), TOLLIP(5), TRAF3(12), TRAF6(4)	58482313	1105	326	864	365	209	326	161	254	151	4	0.0664	1.000	1.000
131	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(11), AKT2(8), AKT3(8), BRD4(22), CAP1(5), CBL(45), CDC42(3), CDKN2A(9), F2RL2(8), FLOT1(7), FLOT2(2), GRB2(11), GSK3A(6), GSK3B(17), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), LNPEP(23), MAPK1(3), MAPK3(4), PARD3(13), PARD6A(2), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PPYR1(8), PTEN(333), PTPN1(11), RAF1(16), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SERPINB6(4), SFN(1), SHC1(14), SLC2A4(8), SORBS1(15), SOS1(16), SOS2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	38664488	1226	323	847	419	188	489	185	220	133	11	0.0188	1.000	1.000
132	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(11), AKT2(8), AKT3(8), BCL10(8), BLNK(2), BTK(12), CARD11(59), CD19(10), CD22(17), CD72(4), CD79A(6), CD79B(3), CHUK(27), CR2(22), FCGR2B(2), FOS(5), GSK3B(17), HRAS(4), IFITM1(2), IKBKB(9), IKBKG(2), INPP5D(10), JUN(2), LILRB3(8), LYN(13), MALT1(13), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RASGRP3(9), SYK(8), VAV1(24), VAV2(20), VAV3(30)	48246786	992	322	738	332	216	318	155	185	116	2	0.0181	1.000	1.000
133	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT1(11), AKT2(8), AKT3(8), BTK(12), FCER1A(6), FYN(17), GAB2(10), GRB2(11), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(10), LAT(3), LCP2(10), LYN(13), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MS4A2(6), PDK1(7), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PRKCA(8), PRKCD(15), PRKCE(6), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SOS1(16), SOS2(17), SYK(8), TNF(2), VAV1(24), VAV2(20), VAV3(30)	46461930	987	321	738	331	206	328	155	194	102	2	0.0387	1.000	1.000
134	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(4), IMPA2(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(16), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), MINPP1(6), MIOX(3), OCRL(21), PI4KA(29), PI4KB(5), PIK3C3(29), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15)	48729399	1216	320	869	449	214	455	181	235	122	9	0.492	1.000	1.000
135	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(14), CRKL(5), DOCK1(24), ELK1(4), FOS(5), GAB1(15), GRB2(11), HGF(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAP4K1(7), MAPK1(3), MAPK3(4), MAPK8(17), MET(55), PAK1(11), PIK3CA(344), PIK3R1(62), PTEN(333), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAF1(16), RAP1A(2), RAP1B(2), RASA1(24), SOS1(16), SRC(3), STAT3(10)	30595431	1130	320	753	426	122	510	171	211	106	10	0.278	1.000	1.000
136	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(11), AKT2(8), AKT3(8), BCR(12), BTK(12), CD19(10), CDKN2A(9), DAPP1(3), FLOT1(7), FLOT2(2), GAB1(15), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), PDK1(7), PHF11(3), PIK3CA(344), PITX2(2), PLCG2(28), PPP1R13B(10), PREX1(27), PTEN(333), PTPRC(36), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SAG(5), SYK(8), TEC(10), VAV1(24)	36676407	1142	320	826	418	183	445	187	209	109	9	0.367	1.000	1.000
137	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	AKT1(11), ASAH1(4), ATF1(6), BRAF(125), CAMP(1), CREB1(3), CREB3(6), CREB5(8), CREBBP(81), CRKL(5), DAG1(10), EGR1(14), EGR2(16), EGR3(6), EGR4(3), ELK1(4), FRS2(6), GNAQ(11), JUN(2), MAP1B(51), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NTRK1(17), OPN1LW(4), PIK3C2G(21), PIK3CA(344), PIK3CD(11), PIK3R1(62), PTPN11(41), RPS6KA3(16), SHC1(14), SRC(3), TERF2IP(4)	31681697	983	320	661	380	140	345	149	226	118	5	0.654	1.000	1.000
138	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(11), AKT2(8), AKT3(8), BAD(1), CASP9(6), CDC42(3), HRAS(4), KDR(42), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPKAPK2(5), MAPKAPK3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NOS3(23), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCA(8), PRKCG(24), PTGS2(10), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SH2D2A(5), SHC2(2), SPHK1(3), SPHK2(5), SRC(3), VEGFA(5)	45329791	909	319	662	341	215	281	144	157	110	2	0.414	1.000	1.000
139	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	90	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ATF4(4), CACNA1C(35), CACNA1D(29), CACNA1F(37), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDC42(3), CGA(3), EGFR(115), ELK1(4), FSHB(6), GNA11(8), GNAQ(11), GNAS(39), GNRH1(4), GNRH2(6), GNRHR(9), GRB2(11), HBEGF(1), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), LHB(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK9(13), MMP14(7), MMP2(18), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLD1(19), PLD2(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCD(15), PRKX(3), PTK2B(13), RAF1(16), SOS1(16), SOS2(17), SRC(3)	83919477	1208	318	1112	416	386	245	147	267	160	3	0.103	1.000	1.000
140	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(27), ADCY8(34), ARAF(10), ATF4(4), BRAF(125), CACNA1C(35), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CREBBP(81), EP300(56), GNAQ(11), GRIA1(38), GRIA2(29), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R1A(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF3(8), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18)	66384440	1114	316	971	429	335	260	120	262	134	3	0.707	1.000	1.000
141	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	78	ACVR1(9), ACVR1C(11), ACVR2B(14), ACVRL1(8), AMHR2(4), BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BMPR1B(15), CHRD(16), COMP(6), CREBBP(81), CUL1(17), DCN(9), E2F4(2), E2F5(6), EP300(56), FST(5), GDF5(13), GDF6(7), ID1(2), ID4(1), IFNG(3), INHBA(21), INHBB(3), INHBC(4), INHBE(3), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(3), MAPK3(4), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), RBL1(21), RBL2(24), RBX1(1), ROCK1(35), ROCK2(20), RPS6KB1(9), RPS6KB2(6), SKP1(2), SMAD1(10), SMAD4(191), SMAD5(4), SMAD7(2), SMAD9(7), SMURF1(9), SMURF2(7), SP1(7), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNF(2), ZFYVE16(23), ZFYVE9(23)	61182620	1001	315	862	370	293	212	116	219	153	8	0.595	1.000	1.000
142	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(14), CREBBP(81), DUSP1(7), EHHADH(15), EP300(56), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(4), ME1(14), MRPL11(1), MYC(5), NCOA1(15), NCOR1(35), NCOR2(44), NFKBIA(1), NR1H3(16), NR2F1(6), NRIP1(18), PDGFA(2), PIK3CA(344), PIK3R1(62), PPARA(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PTGS2(10), RB1(139), RELA(10), RXRA(8), SP1(7), SRA1(3), STAT5A(10), STAT5B(20), TNF(2)	42050973	1048	315	723	365	177	368	139	188	166	10	0.145	1.000	1.000
143	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(10), BRAF(125), C7orf16(11), CACNA1A(28), CRHR1(6), GNA11(8), GNA12(7), GNA13(3), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAS(39), GNAZ(5), GRIA1(38), GRIA2(29), GRIA3(15), GRID2(28), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), IGF1(6), IGF1R(22), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NOS1(31), NOS3(23), NPR1(18), NPR2(17), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), RAF1(16), RYR1(70)	73137813	1191	309	1043	440	388	217	137	299	147	3	0.624	1.000	1.000
144	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADK(7), ADSL(13), ADSS(8), ADSSL1(6), AK1(2), AK5(10), AK7(8), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), FHIT(1), GART(5), GDA(7), GMPR(9), GMPR2(3), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NPR1(18), NPR2(17), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE10A(19), PDE11A(16), PDE1A(10), PDE1C(19), PDE2A(10), PDE3B(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6D(2), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PPAT(8), PRIM1(5), PRIM2(3), PRPS1(9), PRPS1L1(4), PRPS2(6), PRUNE(4), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), XDH(19)	111775779	1263	308	1199	426	370	195	195	303	199	1	0.0996	1.000	1.000
145	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(27), ATM(237), ATR(53), BAI1(13), BAX(16), BID(2), CASP3(4), CASP8(20), CASP9(6), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG1(5), CCNG2(4), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN2A(9), CHEK1(11), CHEK2(30), CYCS(1), DDB2(1), EI24(1), FAS(9), GADD45G(1), GTSE1(5), IGF1(6), IGFBP3(8), MDM2(11), MDM4(7), PPM1D(6), PTEN(333), RCHY1(4), RFWD2(6), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(7), SERPINE1(10), SESN1(5), SESN2(9), SESN3(8), SFN(1), SIAH1(2), STEAP3(6), THBS1(14), TNFRSF10B(8), TP53I3(2), TP73(5), TSC2(17), ZMAT3(12)	41608628	1019	308	762	389	131	378	114	211	165	20	0.848	1.000	1.000
146	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(11), AKT2(8), AKT3(8), BRAF(125), CAB39(2), EIF4B(5), FIGF(6), HIF1A(16), IGF1(6), MAPK1(3), MAPK3(4), PDPK1(4), PGF(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PRKAA1(9), PRKAA2(20), RHEB(5), RICTOR(27), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), STK11(38), TSC1(18), TSC2(17), ULK2(14), ULK3(3), VEGFA(5), VEGFB(3), VEGFC(15)	33606906	941	308	634	332	156	329	141	206	105	4	0.168	1.000	1.000
147	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), BCR(12), BLNK(2), BTK(12), CD19(10), CD22(17), CR2(22), CSK(5), DAG1(10), FLOT1(7), FLOT2(2), GRB2(11), GSK3A(6), GSK3B(17), INPP5D(10), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP4K1(7), MAPK1(3), MAPK3(4), NFATC2(12), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLCG2(28), PPP1R13B(10), PPP3CA(5), PPP3CB(11), PPP3CC(7), PTPRC(36), RAF1(16), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24)	47589464	964	307	731	303	210	307	153	180	110	4	0.00283	1.000	1.000
148	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(11), EIF4A2(12), EIF4G1(19), EIF4G2(16), EIF4G3(19), GHR(12), IRS1(21), MAPK1(3), MAPK14(8), MAPK3(4), MKNK1(4), PABPC1(8), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PRKCA(8), PTEN(333), RPS6KB1(9)	19190355	906	303	563	340	87	419	147	156	87	10	0.259	1.000	1.000
149	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(11), AKT2(8), AKT3(8), BAD(1), BTK(12), CDKN2A(9), DAPP1(3), GRB2(11), GSK3A(6), GSK3B(17), IARS(10), IGFBP1(2), INPP5D(10), PDK1(7), PIK3CA(344), PPP1R13B(10), PTEN(333), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SOS1(16), SOS2(17), TEC(10), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	24300500	941	301	619	349	108	419	147	169	89	9	0.188	1.000	1.000
150	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(11), EIF4A2(12), EIF4B(5), EIF4G1(19), EIF4G2(16), EIF4G3(19), FKBP1A(2), MKNK1(4), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9), TSC1(18), TSC2(17)	18382092	890	298	550	336	88	422	136	144	90	10	0.220	1.000	1.000
151	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(11), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), GSK3B(17), IGF1(6), IGF1R(22), INPPL1(16), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9)	13571114	862	296	523	330	77	425	135	135	80	10	0.392	1.000	1.000
152	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(14), AGT(12), AKT1(11), CALM2(1), CALM3(1), CALR(2), CAMK1(9), CAMK1G(7), CAMK4(9), CREBBP(81), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(10), FGF2(5), FKBP1A(2), GATA4(4), GSK3B(17), HAND1(5), HAND2(2), HRAS(4), IGF1(6), LIF(1), MAP2K1(12), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MEF2C(15), MYH2(42), NFATC2(12), NFATC3(15), NFATC4(12), NPPA(1), PIK3CA(344), PIK3R1(62), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAF1(16), RPS6KB1(9), SYT1(14)	32957459	855	296	614	302	171	301	129	155	96	3	0.100	1.000	1.000
153	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(11), BCAR1(6), CDKN1B(6), GRB2(11), ILK(3), ITGB1(13), MAPK1(3), MAPK3(4), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PTEN(333), PTK2(24), SHC1(14), SOS1(16)	12839244	863	293	520	320	63	424	137	141	87	11	0.182	1.000	1.000
154	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	39	CALM2(1), CALM3(1), CD3D(5), CD3E(2), ELK1(4), FOS(5), FYN(17), GRB2(11), HRAS(4), JUN(2), LAT(3), LCK(9), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PIK3CA(344), PIK3R1(62), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), PTPN7(4), RAC1(2), RAF1(16), RASA1(24), RELA(10), SHC1(14), SOS1(16), SYT1(14), VAV1(24), ZAP70(12)	30910758	761	293	515	254	150	280	112	123	93	3	0.0217	1.000	1.000
155	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(11), AKT2(8), AKT3(8), BPNT1(9), GRB2(11), ILK(3), MAPK1(3), MAPK3(4), PDK1(7), PIK3CA(344), PIK3CD(11), PTEN(333), PTK2B(13), RBL2(24), SHC1(14), SOS1(16)	13697746	819	290	497	308	67	393	136	145	69	9	0.421	1.000	1.000
156	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCR(12), BLNK(2), BTK(12), CD19(10), CSK(5), DAG1(10), EPHB2(16), GRB2(11), ITPKA(3), ITPKB(15), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PI3(3), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLCG2(28), PPP1R13B(10), RAF1(16), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24)	34085306	752	290	517	237	155	268	124	133	69	3	0.00297	1.000	1.000
157	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(9), EIF1(2), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), ELAVL1(5), FLT1(43), FLT4(18), HIF1A(16), HRAS(4), KDR(42), NOS3(23), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTK2(24), PXN(2), SHC1(14), VHL(105)	22291426	783	290	500	293	101	333	128	130	88	3	0.379	1.000	1.000
158	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(2), CHN1(6), LIMK1(8), MAP3K1(21), MYL2(2), MYLK(33), NCF2(10), PAK1(11), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLD1(19), PPP1R12B(33), RAC1(2), RALBP1(8), RPS6KB1(9), TRIO(40), VAV1(24), WASF1(6)	24166713	714	288	475	240	105	267	118	132	86	6	0.0690	1.000	1.000
159	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(12), CALM2(1), CALM3(1), ELK1(4), FCER1A(6), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PAK2(15), PIK3CA(344), PIK3R1(62), PLA2G4A(16), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAF1(16), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24)	27664113	726	287	488	233	125	277	116	124	81	3	0.00652	1.000	1.000
160	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(7), EGF(8), EGFR(115), ELK1(4), FOS(5), GRB2(11), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10)	25493206	776	285	525	267	126	305	124	140	77	4	0.0840	1.000	1.000
161	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), DAG1(10), DGKA(8), ETFA(5), GCA(1), ITGA9(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAPK1(3), MAPK3(4), NR1I3(5), PAK1(11), PDE3A(21), PDE3B(10), PI3(3), PIK3C2G(21), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLDN(1), PSME1(1), RIPK3(6), RPS4X(3), SGCB(7), VASP(4)	31891832	752	285	543	261	135	259	121	147	85	5	0.143	1.000	1.000
162	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	88	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), AKAP1(7), AKAP10(6), AKAP11(30), AKAP12(36), AKAP2(2), AKAP3(26), AKAP4(16), AKAP5(6), AKAP6(44), AKAP7(21), AKAP8(8), AKAP9(75), ARHGEF1(15), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(7), GNA13(3), GNA14(13), GNA15(6), GNAI2(2), GNAI3(2), GNAL(5), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), HRAS(4), IL18BP(4), ITPR1(43), KCNJ3(11), PALM2(1), PDE1A(10), PDE1B(11), PDE1C(19), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PLCB3(15), PPP3CA(5), PPP3CC(7), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKD3(19), RRAS(2), SLC9A1(12), USP5(10)	77959550	1022	284	941	366	306	181	118	226	188	3	0.352	1.000	1.000
163	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MIOX(3), OCRL(21), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CA(344), PIK3CB(6), PIK3CG(41), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28)	29752016	694	283	480	246	134	240	123	134	62	1	0.281	1.000	1.000
164	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(11), AKT3(8), BCAR1(6), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(10), CAPN3(11), CAPN5(14), CAPN6(15), CAPN7(12), CAPN9(5), CAPNS1(4), CAV1(1), CAV2(4), CAV3(4), CDC42(3), CSK(5), DOCK1(24), FYN(17), GIT2(11), GRB2(11), ILK(3), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK10(18), MAPK12(4), MAPK4(4), MAPK6(19), MAPK7(6), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(19), RHO(5), ROCK1(35), ROCK2(20), SDCCAG8(4), SEPP1(4), SHC1(14), SHC3(5), SORBS1(15), SOS1(16), SRC(3), TLN1(23), TNS1(39), VASP(4), VAV2(20), VAV3(30), VCL(10), ZYX(5)	89351139	1051	282	983	387	302	160	113	280	187	9	0.780	1.000	1.000
165	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(27), AKT1(11), BAD(1), BAX(16), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(22), IL3(6), KIT(161), KITLG(3), PIK3CA(344), PIK3R1(62), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), YWHAH(5)	14365102	715	281	450	264	101	333	109	104	65	3	0.360	1.000	1.000
166	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(27), AKT1(11), ASAH1(4), GNAI1(5), GNB1(3), GNGT1(1), ITGAV(21), ITGB3(16), MAPK1(3), MAPK3(4), PDGFA(2), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLCB1(23), PRKCA(8), PTK2(24), RAC1(2), SMPD1(10), SMPD2(3), SPHK1(3), SRC(3)	18830928	643	280	415	236	90	262	111	118	56	6	0.230	1.000	1.000
167	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(64), ASH2L(7), C17orf79(1), CARM1(3), CTCFL(19), DOT1L(10), EED(2), EHMT1(11), EHMT2(10), EZH1(9), EZH2(51), FBXO11(15), HCFC1(13), HSF4(5), JMJD4(2), JMJD6(9), KDM6A(27), MEN1(32), MLL(58), MLL2(67), MLL3(88), MLL4(41), MLL5(32), NSD1(29), OGT(10), PAXIP1(22), PPP1CA(2), PPP1CB(6), PPP1CC(2), PRDM2(36), PRDM7(6), PRDM9(43), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), RBBP5(4), SATB1(17), SETD1A(21), SETD2(55), SETD7(9), SETD8(6), SETDB1(19), SETDB2(6), SETMAR(4), SMYD3(6), STK38(11), SUV39H1(4), SUV39H2(7), SUV420H1(17), SUV420H2(1), SUZ12(5), WHSC1(28), WHSC1L1(10)	78519652	994	279	871	309	259	220	89	224	190	12	0.177	1.000	1.000
168	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(27), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), GNAS(39), GRB2(11), HRAS(4), MAPK1(3), MAPK14(8), MAPK3(4), PIK3CA(344), PIK3R1(62), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAC1(2), RPS6KA1(9), RPS6KA5(13), SOS1(16)	19542475	626	279	394	212	113	257	101	101	52	2	0.0502	1.000	1.000
169	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(11), CREB1(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NFKB1(11), PIK3CA(344), PIK3R1(62), RB1(139), RELA(10), SP1(7)	13584114	654	278	395	223	83	282	103	114	62	10	0.0245	1.000	1.000
170	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	27	AKT1(11), CABIN1(24), CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), HDAC5(14), IGF1(6), IGF1R(22), INSR(21), MAP2K6(5), MAPK14(8), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NFATC2(12), PIK3CA(344), PIK3R1(62), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYT1(14), YWHAH(5)	21577268	620	278	404	236	102	249	104	105	58	2	0.440	1.000	1.000
171	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PDGFA(2), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10)	23650549	719	278	476	236	112	275	113	135	78	6	0.0409	1.000	1.000
172	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), GRB2(11), GSK3A(6), GSK3B(17), IL4R(6), IRS1(21), JAK1(22), JAK3(31), MAP4K1(7), MAPK1(3), MAPK3(4), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PPP1R13B(10), RAF1(16), SHC1(14), SOS1(16), SOS2(17), STAT6(4)	23446042	659	278	420	210	104	262	106	109	74	4	0.0189	1.000	1.000
173	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(237), CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CREB3(6), CREB3L1(6), CREB3L3(7), CREB3L4(5), E2F2(7), E2F3(6), E2F4(2), E2F5(6), E2F6(4), GBA2(15), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MNAT1(4), MYC(5), MYT1(25), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLE(41), POLE2(6), PRIM1(5), RB1(139), RBL1(21), RPA1(12), RPA2(1), RPA3(4), TFDP1(10), TFDP2(5), WEE1(15)	46526449	797	277	654	276	137	242	83	192	127	16	0.281	1.000	1.000
174	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(81), EP300(56), FYN(17), IL2RG(9), IL7(4), IL7R(13), JAK1(22), JAK3(31), LCK(9), NMI(4), PIK3CA(344), PIK3R1(62), PTK2B(13), STAT5A(10), STAT5B(20)	19280876	697	276	444	244	100	280	107	118	89	3	0.212	1.000	1.000
175	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	DIAPH1(7), FYN(17), GSN(4), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PIK3CA(344), PIK3R1(62), PTK2(24), PXN(2), RAF1(16), ROCK1(35), SHC1(14), SRC(3), TLN1(23)	24171661	634	274	400	222	92	236	115	108	75	8	0.135	1.000	1.000
176	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(5), GHR(12), GRB2(11), HRAS(4), INSR(21), IRS1(21), JAK2(55), MAP2K1(12), MAPK1(3), MAPK3(4), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTPN6(4), RAF1(16), RPS6KA1(9), SHC1(14), SLC2A4(8), SOS1(16), SRF(4), STAT5A(10), STAT5B(20)	22334539	682	273	434	251	104	280	115	111	66	6	0.453	1.000	1.000
177	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADK(7), ADSL(13), ADSS(8), AK1(2), AK5(10), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), ATP1B1(4), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), FHIT(1), GART(5), GDA(7), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NPR1(18), NPR2(17), NT5C(1), NT5E(7), NT5M(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE1A(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6B(11), PDE6C(12), PDE7B(6), PDE8A(6), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), PPAT(8), PRPS1(9), PRPS1L1(4), PRPS2(6), PRUNE(4), RRM1(3), RRM2(5)	86149002	991	273	940	331	295	153	141	245	156	1	0.190	1.000	1.000
178	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), HRAS(4), MAPK1(3), MAPK3(4), NFKB1(11), NFKBIA(1), PAK1(11), PIK3CA(344), PIK3R1(62), RAC1(2), RAF1(16), RB1(139), RELA(10), TFDP1(10)	13838106	656	272	392	235	85	285	105	105	66	10	0.120	1.000	1.000
179	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	77	ANPEP(19), CD14(6), CD19(10), CD1A(6), CD1B(6), CD1C(5), CD1D(6), CD2(7), CD22(17), CD33(3), CD34(7), CD36(3), CD37(4), CD38(5), CD3D(5), CD3E(2), CD4(4), CD44(6), CD5(9), CD55(8), CD7(6), CD8A(2), CD8B(4), CD9(3), CR1(20), CR2(22), CSF1(5), CSF1R(16), CSF3(3), CSF3R(19), DNTT(13), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(36), FLT3LG(1), GP5(9), GP9(1), GYPA(8), HLA-DRB1(7), HLA-DRB5(4), IL11(6), IL11RA(4), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL2RA(6), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL7(4), IL7R(13), ITGA1(12), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGAM(14), ITGB3(16), KIT(161), KITLG(3), MME(27), MS4A1(7), TFRC(7), THPO(6), TNF(2), TPO(36)	53533448	806	271	716	291	205	203	105	197	92	4	0.207	1.000	1.000
180	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CBL(45), CFLAR(3), CRKL(5), FOS(5), GRB2(11), HRAS(4), IL2RA(6), IL2RB(5), IL2RG(9), IRS1(21), JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), MYC(5), NMI(4), PIK3CA(344), PIK3R1(62), PPIA(1), PTPN6(4), RAF1(16), RPS6KB1(9), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8)	23628185	702	271	450	228	103	267	123	113	92	4	0.0505	1.000	1.000
181	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(27), ARHGEF1(15), F2(10), F2R(11), GNA12(7), GNA13(3), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), MAP3K7(9), PIK3CA(344), PIK3R1(62), PLCB1(23), PPP1R12B(33), PRKCA(8), PTK2B(13), ROCK1(35)	17531648	620	271	380	218	92	243	92	105	82	6	0.357	1.000	1.000
182	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(11), AKT2(8), AKT3(8), CISH(2), GRB2(11), IARS(10), IL13RA1(6), IL2RG(9), IL4(5), IL4R(6), INPP5D(10), JAK1(22), JAK2(55), JAK3(31), PI3(3), PIK3CA(344), PPP1R13B(10), RPS6KB1(9), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT6(4), TYK2(5)	24712123	629	271	407	219	87	256	106	114	61	5	0.162	1.000	1.000
183	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(31), CDKN2A(9), MDM2(11), MYC(5), PIK3CA(344), PIK3R1(62), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), RAC1(2), RB1(139), TWIST1(3)	12645933	648	270	391	228	80	291	106	102	59	10	0.0427	1.000	1.000
184	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IGF1(6), IGF1R(22), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PTPN11(41), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4)	16583740	636	270	392	212	92	263	106	108	64	3	0.0242	1.000	1.000
185	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), INSR(21), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PTPN11(41), RAF1(16), RASA1(24), SHC1(14), SLC2A4(8), SOS1(16), SRF(4)	17063492	637	269	394	214	91	263	109	110	61	3	0.0255	1.000	1.000
186	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	29	DUSP1(7), GORASP1(13), IKBKG(2), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK5(7), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CA(344), PIK3CD(11), PIK3R1(62), SYT1(14), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4)	18919431	616	269	391	209	96	252	102	104	60	2	0.0748	1.000	1.000
187	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(7), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAPK3(4), MPL(9), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), THPO(6)	20895475	675	269	426	226	95	280	106	111	77	6	0.108	1.000	1.000
188	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(44), ABCA10(36), ABCA12(82), ABCA13(72), ABCA3(24), ABCA4(35), ABCA5(36), ABCA6(35), ABCA7(22), ABCA8(32), ABCA9(39), ABCB1(35), ABCB10(11), ABCB11(19), ABCB4(28), ABCB5(29), ABCB6(8), ABCB7(7), ABCB8(10), ABCB9(7), ABCC1(25), ABCC10(20), ABCC11(17), ABCC12(27), ABCC2(23), ABCC3(11), ABCC4(24), ABCC5(22), ABCC6(13), ABCC8(25), ABCC9(26), ABCD1(5), ABCD2(21), ABCD3(5), ABCD4(10), ABCG1(8), ABCG2(17), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(21), TAP1(9), TAP2(16)	76282590	984	268	966	304	255	148	112	294	164	11	0.0126	1.000	1.000
189	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	80	ATF2(7), BRAF(125), CHUK(27), CREB1(3), DAXX(18), ELK1(4), FOS(5), GRB2(11), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP3K9(11), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAP4K5(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK4(4), MAPK6(19), MAPK7(6), MAPK8(17), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MKNK2(7), MYC(5), NFKB1(11), NFKBIA(1), PAK1(11), PAK2(15), RAC1(2), RAF1(16), RELA(10), RIPK1(7), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KB1(9), RPS6KB2(6), SHC1(14), SP1(7), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8)	62003430	920	268	768	267	223	204	118	227	146	2	0.00565	1.000	1.000
190	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CXCL12(2), CXCR4(7), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), NFKB1(11), PIK3C2G(21), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTK2(24), PTK2B(13), PXN(2), RAF1(16), RELA(10)	18229328	588	266	372	221	87	241	104	97	56	3	0.407	1.000	1.000
191	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(125), CPEB1(10), EGFR(115), ERBB2(37), ERBB4(65), ETS1(10), ETS2(5), ETV6(11), ETV7(3), GRB2(11), MAP2K1(12), MAPK1(3), MAPK3(4), NOTCH2(35), NOTCH3(31), NOTCH4(20), PIWIL1(31), PIWIL2(16), PIWIL3(15), PIWIL4(10), RAF1(16), SOS1(16), SOS2(17), SPIRE1(6), SPIRE2(9)	30095442	633	266	502	202	138	173	84	175	63	0	0.0626	1.000	1.000
192	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(11), BCL2(2), BCR(12), CRKL(5), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), MYC(5), PIK3CA(344), PIK3R1(62), RAF1(16), SOS1(16), STAT1(17), STAT5A(10), STAT5B(20)	18046223	651	265	414	213	94	276	109	108	59	5	0.0147	1.000	1.000
193	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(11), BAD(1), BCL2L1(1), CASP9(6), CDC42(3), CHUK(27), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(12), MAPK3(4), NFKB1(11), PIK3CA(344), PIK3R1(62), RAC1(2), RAF1(16), RALA(8), RALBP1(8), RALGDS(9), RELA(10)	12582595	544	262	323	179	86	229	101	80	46	2	0.0116	1.000	1.000
194	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	87	ACTB(4), BAD(1), BCL2(2), CABIN1(24), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(9), CD3E(2), CD69(4), CDKN1A(2), CNR1(13), CREBBP(81), CSNK2A1(7), CSNK2B(2), CTLA4(5), EGR2(16), EGR3(6), EP300(56), FCER1A(6), FCGR3A(5), FOS(5), FOSL1(1), GATA3(17), GATA4(4), GRLF1(19), GSK3A(6), GSK3B(17), HRAS(4), ICOS(2), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL13(2), IL1B(5), IL2(5), IL2RA(6), IL3(6), IL4(5), IL6(7), IL8(6), ITK(26), KPNA5(12), MAPK14(8), MAPK8(17), MAPK9(13), MEF2A(7), MEF2D(3), MYF5(7), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB2(6), NFKBIB(5), NFKBIE(5), NPPB(5), NUP214(22), OPRD1(6), P2RX7(13), PAK1(11), PIN1(2), PPIA(1), PPP3CB(11), PPP3CC(7), PPP3R1(4), PTPRC(36), RELA(10), RPL13A(1), SFN(1), SLA(8), SP1(7), SP3(13), TGFB1(2), TNF(2), TRAF2(8), TRPV6(20), VAV1(24), VAV2(20), VAV3(30), XPO5(8)	58290451	818	261	751	286	246	199	88	172	113	0	0.148	1.000	1.000
195	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(11), BAD(1), GRB2(11), HRAS(4), IGF1R(22), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), PIK3CA(344), PIK3R1(62), RAF1(16), SHC1(14), SOS1(16), YWHAH(5)	12595172	546	261	318	176	74	233	101	82	53	3	0.0166	1.000	1.000
196	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(8), ADAM17(13), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), CASP3(4), CDC42(3), CHUK(27), CSK(5), CXCL1(1), EGFR(115), F11R(4), GIT1(4), HBEGF(1), IGSF5(16), IKBKB(9), IKBKG(2), IL8(6), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP3K14(6), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK8(17), MAPK9(13), MET(55), NFKB1(11), NFKB2(6), NFKBIA(1), NOD1(10), PAK1(11), PLCG1(19), PLCG2(28), PTPN11(41), PTPRZ1(43), RAC1(2), RELA(10), SRC(3), TCIRG1(7), TJP1(25)	47655324	716	260	621	241	163	224	89	155	84	1	0.113	1.000	1.000
197	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(45), CD28(5), CD3D(5), CSK(5), CTLA4(5), DAG1(10), DTYMK(1), EPHB2(16), FBXW7(156), GRAP2(7), GRB2(11), ITK(26), ITPKA(3), ITPKB(15), LAT(3), LCK(9), LCP2(10), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLCG1(19), PTPRC(36), RAF1(16), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), SOS1(16), SOS2(17), VAV1(24), ZAP70(12)	36408350	624	260	522	207	166	151	69	133	104	1	0.139	1.000	1.000
198	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(11), ANXA1(4), CALM2(1), CALM3(1), GNAS(39), GNB1(3), GNGT1(1), NFKB1(11), NOS3(23), NPPA(1), NR3C1(11), PIK3CA(344), PIK3R1(62), RELA(10), SYT1(14)	11393777	539	258	304	187	83	236	91	79	48	2	0.111	1.000	1.000
199	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(11), DPM2(1), GRB2(11), HRAS(4), KLK2(4), NTRK1(17), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), SHC1(14), SOS1(16)	10659201	511	258	291	186	50	231	98	80	49	3	0.298	1.000	1.000
200	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	IL18(3), ITGB1(13), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LAT(3), MAP2K1(12), MAPK3(4), PAK1(11), PIK3CA(344), PIK3R1(62), PTK2B(13), PTPN6(4), RAC1(2), SYK(8), VAV1(24)	12437604	522	257	315	183	64	228	92	91	45	2	0.170	1.000	1.000
201	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(11), PIK3CA(344), PIK3R1(62), PLCB1(23), PLCG1(19), PRKCA(8), VAV1(24)	9053724	491	257	282	182	60	224	92	77	36	2	0.411	1.000	1.000
202	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(11), CREB1(3), GRB2(11), HRAS(4), MAPK1(3), MAPK3(4), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NTRK1(17), PIK3CA(344), PIK3R1(62), PLCG1(19), RPS6KA1(9), SHC1(14)	12775174	532	256	318	194	65	236	98	79	51	3	0.384	1.000	1.000
203	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BTRC(11), CSNK1A1(3), CSNK1A1L(9), CSNK1D(15), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(7), DHH(4), FBXW11(13), GLI1(22), GLI2(28), GLI3(44), GSK3B(17), HHIP(16), IHH(5), LRP2(130), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), PTCH1(143), PTCH2(21), RAB23(4), SHH(3), SMO(13), STK36(20), SUFU(5), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	38049670	715	256	617	261	227	157	82	139	107	3	0.464	1.000	1.000
204	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(7), DPM2(1), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), KLK2(4), MAP2K1(12), MAPK3(4), MAPK8(17), NGFR(5), PIK3CA(344), PIK3R1(62), PLCG1(19), RAF1(16), SHC1(14), SOS1(16)	12844340	547	256	324	185	72	237	97	87	51	3	0.0671	1.000	1.000
205	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(5), CD3D(5), CD3E(2), CD80(6), CD86(2), CTLA4(5), GRB2(11), HLA-DRB1(7), ICOS(2), IL2(5), ITK(26), LCK(9), PIK3CA(344), PIK3R1(62), PTPN11(41)	8282133	532	254	300	185	53	252	93	88	42	4	0.0816	1.000	1.000
206	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHX58(6), ENPP1(17), ENPP3(12), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), G6PC(5), G6PC2(3), GAA(14), GANC(9), GBA(4), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), IFIH1(22), LYZL1(4), MGAM(26), MOV10L1(23), NUDT5(1), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SI(28), SKIV2L2(13), SMARCA2(22), SMARCA5(18), TREH(6), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UXS1(9)	85635782	923	252	856	275	257	158	110	220	175	3	0.0469	1.000	1.000
207	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(7), ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG6(5), ALG8(13), ALG9(8), B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT5(5), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(10), CHST11(6), CHST12(6), CHST14(1), CHST2(13), CHST3(7), CHST4(8), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(14), EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), FUT11(3), FUT8(11), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GANAB(13), GCNT1(9), GCNT3(6), GCNT4(14), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), NDST1(10), NDST2(10), NDST3(19), NDST4(13), OGT(10), RPN1(4), RPN2(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(6), STT3B(11), UST(12), XYLT1(14), XYLT2(15)	71361348	863	252	803	320	283	148	92	200	140	0	0.922	1.000	1.000
208	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(11), CAT(8), GH1(5), GHR(12), HRAS(4), IGF1(6), IGF1R(22), PIK3CA(344), PIK3R1(62), SHC1(14), SOD2(4)	8888486	492	252	278	179	59	215	93	78	44	3	0.253	1.000	1.000
209	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(11), BAD(1), CHRNB1(10), CHRNG(8), MUSK(15), PIK3CA(344), PIK3R1(62), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(10), YWHAH(5)	10689274	511	251	303	186	62	225	95	78	49	2	0.370	1.000	1.000
210	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(11), BAD(1), CASP9(6), CHUK(27), GH1(5), GHR(12), NFKB1(11), NFKBIA(1), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), RELA(10), YWHAH(5)	9817337	502	251	288	175	63	223	93	80	41	2	0.0467	1.000	1.000
211	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), PAK1(11), PDGFRA(64), PIK3CA(344), PIK3R1(62), RAC1(2), WASL(18)	9475375	533	250	318	186	55	233	97	98	46	4	0.0525	1.000	1.000
212	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(11), AKT2(8), AKT3(8), CDKN1A(2), ELK1(4), GRB2(11), HRAS(4), MAP2K1(12), MAP2K2(3), NGFR(5), NTRK1(17), PIK3CA(344), PIK3CD(11), SHC1(14), SOS1(16)	10438025	470	250	276	177	59	198	99	82	31	1	0.387	1.000	1.000
213	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(25), BDKRB1(4), BDKRB2(6), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(17), C2(10), C3(25), C3AR1(12), C4A(3), C4B(2), C4BPA(12), C4BPB(1), C5(25), C5AR1(8), C6(27), C7(11), C8A(14), C8B(23), C8G(1), C9(12), CD46(4), CD55(8), CFB(7), CFH(32), CFI(9), CPB2(11), CR1(20), CR2(22), F10(5), F11(8), F12(5), F13A1(15), F13B(12), F2(10), F2R(11), F3(2), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), KNG1(9), MASP1(23), MASP2(10), MBL2(3), PLAT(11), PLAU(7), PLAUR(9), PLG(27), PROC(3), PROS1(12), SERPINA1(9), SERPINA5(9), SERPINC1(8), SERPIND1(6), SERPINE1(10), SERPINF2(4), SERPING1(7), TFPI(9), THBD(3), VWF(36)	63684208	814	246	775	288	205	132	116	217	140	4	0.598	1.000	1.000
214	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(40), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ADIPOR1(2), ADIPOR2(6), AKT1(11), AKT2(8), AKT3(8), CAMKK1(2), CAMKK2(9), CD36(3), CHUK(27), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), G6PC(5), G6PC2(3), IKBKB(9), IKBKG(2), IRS1(21), IRS4(36), JAK1(22), JAK2(55), JAK3(31), LEP(1), LEPR(21), MAPK10(18), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NPY(6), PCK1(6), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(16), PTPN11(41), RELA(10), RXRA(8), RXRB(8), RXRG(11), SLC2A1(7), SLC2A4(8), STAT3(10), STK11(38), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5)	54515479	783	246	681	252	211	202	99	169	98	4	0.0323	1.000	1.000
215	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(11), AKT2(8), AKT3(8), ASAH1(4), BRAF(125), DAG1(10), DRD2(9), EGFR(115), EPHB2(16), GRB2(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PI3(3), PIK3CB(6), PITX2(2), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), RAF1(16), RGS20(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT3(10), TERF2IP(4)	38975867	677	246	555	229	163	176	80	180	76	2	0.253	1.000	1.000
216	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(237), ATR(53), BRCA1(32), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(11), CHEK2(30), EP300(56), MDM2(11), MYT1(25), PRKDC(85), RPS6KA1(9), WEE1(15), YWHAH(5), YWHAQ(1)	28157126	611	245	476	235	102	201	56	133	107	12	0.837	1.000	1.000
217	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(237), ATR(53), BRCA1(32), BRCA2(99), CHEK1(11), CHEK2(30), FANCA(12), FANCC(8), FANCD2(42), FANCE(4), FANCF(4), FANCG(7), HUS1(8), MRE11A(20), RAD1(2), RAD17(9), RAD50(30), RAD9A(1), TREX1(3)	30709853	612	242	451	232	71	196	48	146	139	12	0.960	1.000	1.000
218	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(237), BMPR1B(15), CCND2(3), CDK4(4), CDKN1B(6), DAZL(3), DMC1(7), EGR1(14), ESR2(8), FSHR(19), GJA4(3), INHA(6), LHCGR(27), MLH1(68), MSH5(8), NCOR1(35), NR5A1(5), NRIP1(18), PGR(16), PRLR(10), PTGER2(2), SMPD1(10), VDR(4), ZP2(16)	23733670	544	239	433	183	101	164	49	121	101	8	0.321	1.000	1.000
219	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(31), ATM(237), ATR(53), CCNA1(18), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), DHFR(1), GSK3B(17), HDAC1(5), RB1(139), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2)	20217609	576	238	441	222	95	203	42	116	101	19	0.744	1.000	1.000
220	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	53	ALG2(8), BAK1(2), BAX(16), BFAR(9), BTK(12), CAD(23), CASP10(7), CASP3(4), CASP8(20), CASP8AP2(30), CD7(6), CSNK1A1(3), DAXX(18), DEDD(3), DEDD2(1), DFFA(6), DIABLO(3), EGFR(115), EPHB2(16), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(6), MAP3K1(21), MAP3K5(16), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MET(55), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PFN2(4), PTPN13(23), RALBP1(8), RIPK1(7), ROCK1(35), SMPD1(10), TPX2(10), TRAF2(8), TUFM(6)	44980435	633	237	566	212	130	172	68	160	96	7	0.361	1.000	1.000
221	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(6), APAF1(27), ARHGDIB(5), BAG4(10), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), GSN(4), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK8(17), MDM2(11), NFKB1(11), NFKBIA(1), NUMA1(26), PAK2(15), PRKCD(15), PRKDC(85), PSEN1(4), PSEN2(6), PTK2(24), RASA1(24), RB1(139), RELA(10), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8)	45065804	692	236	577	224	148	194	58	152	130	10	0.298	1.000	1.000
222	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	49	ADORA3(15), ALG6(5), CCKBR(16), CCR2(7), CCR3(11), CCR5(11), CELSR1(28), CELSR2(33), CELSR3(28), CHRM2(29), CHRM3(23), CIDEB(1), CXCR3(5), EDNRA(9), EMR2(11), EMR3(19), F2R(11), FSHR(19), GHRHR(2), GNRHR(9), GPR116(21), GPR132(6), GPR133(16), GPR143(4), GPR17(3), GPR18(5), GPR55(2), GPR56(6), GPR61(12), GPR77(4), GPR84(8), GPR88(4), GRM1(37), GRPR(4), HRH4(6), LGR6(9), LPHN2(30), LPHN3(30), NTSR1(5), OR2M4(17), OR8G1(3), OR8G2(9), PTGFR(8), SMO(13), SSTR2(6), TAAR5(10), VN1R1(7)	39268960	577	235	517	208	184	111	54	143	84	1	0.425	1.000	1.000
223	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), BTRC(11), CDC16(6), CDC20(3), CDC23(12), CDC26(1), CDC27(21), CUL1(17), CUL2(15), CUL3(8), FBXW11(13), FBXW7(156), FZR1(4), ITCH(7), RBX1(1), SKP1(2), SKP2(3), SMURF1(9), SMURF2(7), TCEB1(1), TCEB2(1), UBA1(10), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(4), UBE2E2(4), UBE2E3(1), VHL(105), WWP1(21), WWP2(9)	28199328	503	234	385	184	124	129	57	110	80	3	0.494	1.000	1.000
224	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	61	AGTR1(14), AGTR2(17), ATP8A1(16), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CX3CR1(6), CXCR3(5), CXCR4(7), CXCR6(1), EDNRA(9), EDNRB(19), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(4), GRPR(4), LHCGR(27), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), NMBR(4), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), PPYR1(8), SSTR1(12), SSTR2(6), SSTR4(14), TAC4(4), TACR1(9), TACR2(4), TACR3(18), TRHR(9)	32365472	529	226	479	202	181	103	58	135	52	0	0.308	1.000	1.000
225	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CDK2(5), CDK4(4), CHEK1(11), MYT1(25), RB1(139), WEE1(15), YWHAH(5)	11948512	469	225	344	160	74	178	31	102	68	16	0.243	1.000	1.000
226	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(27), ATM(237), BAX(16), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDKN1A(2), MDM2(11), PCNA(5), RB1(139), TIMP3(11)	12170451	467	218	331	171	61	176	31	101	81	17	0.619	1.000	1.000
227	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	BCL2(2), CHUK(27), DAXX(18), EGF(8), EGFR(115), ETS1(10), ETS2(5), FOS(5), HOXA7(4), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK1(3), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), NFKB1(11), NFKBIA(1), PPP2CA(3), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), RAF1(16), RELA(10), RIPK1(7), SP1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	32226823	471	216	413	173	130	143	59	94	45	0	0.345	1.000	1.000
228	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(31), ATM(237), BRCA1(32), CDKN1A(2), CHEK1(11), CHEK2(30), JUN(2), MAPK8(17), MDM2(11), MRE11A(20), NFKB1(11), NFKBIA(1), RAD50(30), RBBP8(15), RELA(10), TP73(5)	19727006	465	212	353	202	70	169	33	101	83	9	0.996	1.000	1.000
229	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(115), ELK1(4), GNAS(39), GNB1(3), GNGT1(1), GRB2(11), HRAS(4), IGF1R(22), ITGB1(13), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MYC(5), NGFR(5), PDGFRA(64), PPP2CA(3), PTPRR(16), RAF1(16), RPS6KA1(9), RPS6KA5(13), SHC1(14), SOS1(16), SRC(3), STAT3(10)	22414341	424	210	354	154	111	131	55	83	40	4	0.338	1.000	1.000
230	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	40	ADAM17(13), APH1A(2), CREBBP(81), CTBP1(5), CTBP2(14), DLL1(10), DLL3(7), DLL4(7), DTX1(6), DTX2(10), DTX3(3), DTX3L(11), DTX4(8), DVL2(12), DVL3(10), EP300(56), HDAC1(5), HDAC2(8), HES1(2), JAG1(16), LFNG(6), MAML1(12), MAML2(9), MAML3(4), MFNG(1), NCOR2(44), NCSTN(6), NOTCH2(35), NOTCH3(31), NOTCH4(20), NUMB(10), NUMBL(6), PSEN1(4), PSEN2(6), PSENEN(2), PTCRA(5), RBPJ(21), RBPJL(11), RFNG(1), SNW1(10)	38604140	530	209	467	232	154	101	68	91	115	1	0.987	1.000	1.000
231	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTNNB1(120), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3)	32443702	514	209	431	200	121	122	64	121	82	4	0.783	1.000	1.000
232	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTNNB1(120), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3)	32443702	514	209	431	200	121	122	64	121	82	4	0.783	1.000	1.000
233	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(6), CDC34(2), CDK2(5), CUL1(17), FBXW7(156), RB1(139), TFDP1(10)	5993566	335	206	218	121	72	102	18	70	64	9	0.377	1.000	1.000
234	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(11), APAF1(27), ATM(237), BAD(1), BAX(16), BCL2(2), BCL2L1(1), BID(2), CASP3(4), CASP6(3), CASP7(3), CASP9(6), CYCS(1), EIF2S1(3), PRKCA(8), PTK2(24), PXN(2), STAT1(17), TLN1(23)	18504039	391	205	302	158	61	127	37	85	71	10	0.961	1.000	1.000
235	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(14), AKT1(11), BDKRB2(6), CALM2(1), CALM3(1), CAV1(1), CHRM1(4), CHRNA1(12), FLT1(43), FLT4(18), KDR(42), NOS3(23), PDE2A(10), PDE3A(21), PDE3B(10), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKG1(18), PRKG2(12), RYR2(138), SLC7A1(6), SYT1(14), TNNI1(2)	25500072	442	203	424	158	119	97	52	112	60	2	0.395	1.000	1.000
236	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(11), BCL2(2), EGFR(115), IGF1R(22), MYC(5), POLR2A(14), PPP2CA(3), PRKCA(8), RB1(139), TEP1(29), TERF1(6), TERT(10), TNKS(11), XRCC5(13)	18639879	388	203	309	156	81	140	42	68	49	8	0.738	1.000	1.000
237	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CAT(8), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADHA(12), KMO(16), KYNU(9), MAOA(7), MAOB(9), SDS(3), TDO2(11), TPH1(4), WARS(4), WARS2(7)	37713531	481	203	450	142	157	91	52	128	52	1	0.0183	1.000	1.000
238	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(7), CDC40(7), CLK2(3), CLK3(8), CLK4(17), COL2A1(20), CPSF1(15), CPSF2(10), CPSF3(9), CPSF4(5), CSTF1(5), CSTF2(2), CSTF2T(14), CSTF3(13), DDIT3(5), DDX1(15), DDX20(7), DHX15(10), DHX16(20), DHX38(14), DHX8(16), DHX9(13), DICER1(25), DNAJC8(5), FUS(2), GIPC1(4), LSM2(1), METTL3(6), NCBP1(12), NCBP2(2), NONO(13), NUDT21(1), NXF1(11), PABPN1(2), PAPOLA(8), PHF5A(1), POLR2A(14), PPM1G(4), PRPF18(5), PRPF3(9), PRPF4(10), PRPF4B(22), PRPF8(19), PSKH1(2), PTBP1(4), PTBP2(14), RBM17(6), RBM5(15), RNGTT(7), RNMT(6), RNPS1(2), SF3A1(11), SF3A2(5), SF3A3(1), SF3B1(18), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(3), SNRPA1(2), SNRPB(3), SNRPB2(3), SNRPD1(2), SNRPD3(2), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(9), SRPK2(12), SRRM1(18), SUPT5H(20), TXNL4A(2), U2AF1(4), U2AF2(8), XRN2(12)	71972919	636	201	592	202	180	92	66	163	134	1	0.766	1.000	1.000
239	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(2), AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), AFMID(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CARM1(3), CAT(8), CYP1A1(10), CYP1A2(11), CYP1B1(14), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADH(2), HADHA(12), HEMK1(1), HSD17B10(3), HSD17B4(9), INMT(4), KMO(16), KYNU(9), LCMT1(1), LCMT2(6), LNX1(19), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), NFX1(11), OGDH(14), OGDHL(16), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), TDO2(11), TPH1(4), TPH2(12), WARS(4), WARS2(7), WBSCR22(2)	41182103	458	200	427	155	136	81	58	122	61	0	0.277	1.000	1.000
240	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(7), AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PRIM1(5), PRIM2(3), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), TK1(2), TK2(3), TXNRD1(9), TXNRD2(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UPB1(9), UPP1(5), UPP2(6), UPRT(7)	56169458	575	199	549	165	152	92	91	153	87	0	0.00515	1.000	1.000
241	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(5), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CFLAR(3), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), PTPN13(23), RB1(139), RIPK2(5), SPTAN1(30)	26633770	455	198	384	160	71	136	38	114	86	10	0.749	1.000	1.000
242	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	62	ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), CDS1(15), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CHPT1(4), CRLS1(1), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), ESCO1(22), ESCO2(18), ETNK1(3), ETNK2(12), GNPAT(19), GPAM(5), GPD1(3), GPD1L(5), GPD2(11), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(34), MYST4(33), NAT6(2), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(14), SH3GLB1(6)	43812988	506	196	453	189	145	85	68	133	74	1	0.777	1.000	1.000
243	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(35), AKT1(11), ATM(237), BAX(16), CDKN1A(2), CPB2(11), CSNK1A1(3), CSNK1D(15), FHL2(3), HIF1A(16), IGFBP3(8), MAPK8(17), MDM2(11), NFKBIB(5), NQO1(1)	13141694	391	196	305	128	59	128	35	93	67	9	0.371	1.000	1.000
244	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(237), ATR(53), CDC25C(6), CHEK1(11), CHEK2(30), YWHAH(5)	10897669	342	196	243	136	44	127	24	73	63	11	0.895	1.000	1.000
245	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(14), ADCY4(14), ADCY6(13), ADCY8(34), CACNA1A(28), CACNA1B(40), GNAS(39), GNAT3(4), GNB1(3), GNB3(6), GNG3(2), GRM4(15), ITPR3(44), KCNB1(22), PDE1A(10), PLCB2(11), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), SCNN1A(8), SCNN1B(8), SCNN1G(12), TAS1R1(13), TAS1R2(22), TAS2R1(5), TAS2R10(10), TAS2R13(9), TAS2R14(2), TAS2R16(7), TAS2R3(6), TAS2R38(7), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(3), TAS2R46(1), TAS2R5(4), TAS2R50(10), TAS2R60(4), TAS2R7(4), TAS2R8(9), TAS2R9(3), TRPM5(5)	35670165	485	195	463	178	183	65	47	112	77	1	0.698	1.000	1.000
246	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	53	ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), CARM1(3), DBH(9), DCT(22), DDC(5), ECH1(2), ESCO1(22), ESCO2(18), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HEMK1(1), HGD(6), HPD(7), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), MYST3(34), MYST4(33), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SH3GLB1(6), TAT(16), TPO(36), TYR(12), TYRP1(6), WBSCR22(2)	39403230	474	194	426	176	135	95	56	124	63	1	0.565	1.000	1.000
247	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(5), BAG4(10), CASP2(8), CASP3(4), CASP8(20), CRADD(4), DFFA(6), DFFB(2), FADD(1), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MADD(26), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), RB1(139), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TRAF2(8)	24949108	451	194	375	153	88	129	32	103	88	11	0.563	1.000	1.000
248	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1C1(2), AKR1C2(3), AKR1C3(2), AKR1C4(12), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), CYP1A1(10), CYP1A2(11), CYP1B1(14), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2F1(7), CYP2S1(8), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9)	38543255	474	193	418	127	116	98	48	132	79	1	0.00853	1.000	1.000
249	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(7), ACADL(6), ACADM(12), ACOX1(11), ACOX2(8), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP27A1(4), CYP4A11(8), CYP4A22(13), CYP7A1(14), CYP8B1(10), DBI(2), EHHADH(15), FABP1(2), FABP2(9), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FABP7(1), FADS2(12), GK(5), GK2(16), HMGCS2(6), ILK(3), LPL(12), ME1(14), MMP1(6), NR1H3(16), OLR1(10), PCK1(6), PCK2(6), PDPK1(4), PLTP(12), PPARA(7), PPARD(5), PPARG(4), RXRA(8), RXRB(8), RXRG(11), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(7), SLC27A4(3), SLC27A5(9), SLC27A6(20), SORBS1(15), UBC(7), UCP1(8)	44630667	517	192	473	144	163	73	75	132	74	0	0.00366	1.000	1.000
250	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(27), BAD(1), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(18), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), GZMB(5), HELLS(13), IKBKB(9), IKBKG(2), IRF1(6), IRF2(10), IRF3(4), IRF4(5), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP3K1(21), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), NFKBIB(5), NFKBIE(5), PLEKHG5(9), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF10B(8), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFSF10(3), TP73(5), TRAF1(7), TRAF2(8), TRAF3(12)	36525793	443	189	383	135	104	85	49	98	106	1	0.287	1.000	1.000
251	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(6), BAD(1), BRAF(125), CREB1(3), CREB3(6), CREB5(8), DUSP4(6), DUSP6(7), DUSP9(9), EEF2K(11), GRB2(11), MAP2K1(12), MAP2K2(3), MAP3K8(4), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MOS(10), NFKB1(11), RAP1A(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), SHC1(14), SOS1(16), SOS2(17), TRAF3(12)	20384970	362	187	270	115	68	98	40	105	50	1	0.159	1.000	1.000
252	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(32), CARM1(3), CCND1(2), CREBBP(81), EP300(56), ERCC3(19), ESR1(21), GRIP1(15), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), MEF2C(15), NCOR2(44), NR0B1(11), NRIP1(18), PELP1(11), POLR2A(14), SRA1(3), TBP(2)	31101277	431	186	375	191	113	89	45	82	102	0	0.997	1.000	1.000
253	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CHEK1(11), MYT1(25), WEE1(15), YWHAH(5)	9731376	321	185	248	108	54	113	24	74	48	8	0.307	1.000	1.000
254	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(42), AR(26), ESR1(21), ESR2(8), HNF4A(12), NPM1(3), NR0B1(11), NR1D1(8), NR1D2(10), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(5), NR2C2(11), NR2E1(13), NR2F1(6), NR2F2(11), NR3C1(11), NR4A1(3), NR4A2(16), NR5A1(5), NR5A2(9), PGR(16), PPARA(7), PPARD(5), PPARG(4), RARA(6), RARB(20), RARG(10), ROR1(23), RORA(6), RORC(6), RXRA(8), RXRB(8), RXRG(11), THRA(6), THRB(14), VDR(4)	26843553	406	185	379	136	138	71	47	91	57	2	0.247	1.000	1.000
255	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	34	AKT1(11), ATF2(7), CDC42(3), DLD(4), DUSP10(6), DUSP4(6), GAB1(15), GCK(6), IL1R1(7), JUN(2), MAP2K5(6), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK10(18), MAPK7(6), MAPK8(17), MAPK9(13), MYEF2(14), NFATC3(15), NR2C2(11), PAPPA(39), SHC1(14), TRAF6(4), ZAK(12)	32319345	424	185	371	116	113	69	54	97	89	2	0.0503	1.000	1.000
256	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(12), AGTR2(17), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDK5(3), F2(10), FYN(17), GNA11(8), GNAI1(5), GNB1(3), GNGT1(1), GRB2(11), HRAS(4), JAK2(55), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MAPT(11), MYLK(33), PLCG1(19), PRKCA(8), PTK2B(13), RAF1(16), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), SYT1(14)	28812736	403	184	345	147	102	110	47	82	58	4	0.605	1.000	1.000
257	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AGK(7), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CEL(13), DAK(8), DGAT1(5), DGAT2(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), GK(5), GK2(16), GLA(7), GLB1(9), GPAM(5), LCT(46), LIPA(3), LIPC(6), LIPF(3), LIPG(4), LPL(12), MGLL(2), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	39025910	468	184	432	178	131	73	67	144	52	1	0.655	1.000	1.000
258	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(12), AGTR1(14), ATF2(7), CALM2(1), CALM3(1), EGFR(115), ELK1(4), GNAQ(11), GRB2(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), MEF2A(7), MEF2C(15), MEF2D(3), PAK1(11), PRKCA(8), PTK2(24), PTK2B(13), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SRC(3), SYT1(14)	22756844	388	182	341	138	82	115	44	95	51	1	0.440	1.000	1.000
259	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(45), CSF1R(16), EGF(8), EGFR(115), GRB2(11), MET(55), PDGFRA(64), PRKCA(8), SH3GLB1(6), SH3GLB2(6), SH3KBP1(8), SRC(3)	13825164	345	182	298	143	51	143	48	78	23	2	0.671	1.000	1.000
260	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	88	ANK2(84), B3GALT4(4), CDR1(8), DGKI(22), FAU(2), IL6ST(15), MRPL19(4), PIGK(12), RPL10(3), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(6), RPL6(4), RPL7(4), RPL7A(1), RPL8(3), RPL9(4), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(2), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS4X(3), RPS5(2), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), RPS7(1), RPS9(3), RPSA(1), SLC36A2(6), TSPAN9(5), UBA52(3), UBB(3), UBC(7)	33919000	378	181	355	108	98	76	51	94	57	2	0.122	1.000	1.000
261	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(81), DAXX(18), HRAS(4), PAX3(26), PML(12), RARA(6), RB1(139), SIRT1(8), SP100(15), TNF(2), TNFRSF1A(4), TNFRSF1B(1)	11937104	316	180	243	121	73	113	23	52	47	8	0.572	1.000	1.000
262	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), HSD3B7(3), NSD1(29), OGDH(14), OGDHL(16), PIPOX(9), PLOD1(8), PLOD2(10), PLOD3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SETD1A(21), SETD7(9), SETDB1(19), SHMT1(7), SHMT2(5), SPCS1(3), SPCS3(2), SUV39H1(4), SUV39H2(7), TMLHE(6)	38267916	398	176	366	120	135	63	41	92	67	0	0.0981	1.000	1.000
263	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(35), ATP4A(20), ATP4B(3), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5L(2), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), COX10(6), COX15(8), COX17(1), COX4I1(5), COX4I2(4), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(6), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(3), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(8), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(4), NDUFC1(1), NDUFC2(2), NDUFS1(16), NDUFS2(6), NDUFS3(4), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(5), PPA1(3), PPA2(5), SDHA(14), SDHB(3), SDHD(4), TCIRG1(7), UQCRB(2), UQCRC1(4), UQCRC2(13), UQCRFS1(3), UQCRH(1)	38676698	450	175	409	130	145	90	54	86	75	0	0.00779	1.000	1.000
264	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHFR(1), DHX58(6), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), FPGS(4), GGH(2), IFIH1(22), MOV10L1(23), NUDT5(1), QDPR(2), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SKIV2L2(13), SMARCA2(22), SMARCA5(18), SPR(7)	42240555	478	174	432	156	149	83	53	106	85	2	0.327	1.000	1.000
265	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), BCR(12), CAPN1(2), CAPNS1(4), CAPNS2(4), CAV1(1), CRKL(5), CSK(5), FYN(17), GRB2(11), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MAPK8(17), PPP1R12B(33), PTK2(24), PXN(2), RAF1(16), RAP1A(2), ROCK1(35), SHC1(14), SOS1(16), SRC(3), TLN1(23), VCL(10), ZYX(5)	30770205	372	173	318	123	105	67	43	78	73	6	0.381	1.000	1.000
266	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), F10(5), F11(8), F12(5), F2(10), F2R(11), F5(37), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), PROC(3), PROS1(12), SERPINC1(8), SERPING1(7)	31265399	375	172	347	149	83	72	55	99	64	2	0.679	1.000	1.000
267	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(27), CREBBP(81), DUSP1(7), EP300(56), IKBKB(9), IL1B(5), IL8(6), MAP2K3(11), MAP2K6(5), MAP3K14(6), MAP3K7(9), MAPK14(8), MYD88(4), NFKB1(11), NFKBIA(1), NR3C1(11), RELA(10), TGFBR1(20), TGFBR2(26), TLR2(12), TNF(2)	20033236	327	172	281	114	87	98	34	63	44	1	0.294	1.000	1.000
268	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(45), EGF(8), EGFR(115), GRB2(11), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), PTPRB(21), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SPRY1(10), SPRY2(2), SPRY4(7), SRC(3)	16287639	315	172	267	109	64	107	48	60	35	1	0.195	1.000	1.000
269	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), CEL(13), DGAT1(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), GK(5), GLA(7), GLB1(9), LCT(46), LIPC(6), LIPF(3), LIPG(4), LPL(12), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	31815098	404	171	370	144	112	73	57	115	46	1	0.347	1.000	1.000
270	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTG2(6), ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), CDC42(3), CFL1(2), CFL2(2), FLNA(31), FLNC(39), FSCN1(5), FSCN3(6), GDI1(1), GDI2(2), LIMK1(8), MYH2(42), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PFN2(4), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), VASP(4), WASF1(6), WASL(18)	30035145	406	171	373	137	120	63	49	89	80	5	0.286	1.000	1.000
271	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ENPP1(17), ENPP3(12), G6PC(5), GAA(14), GANAB(13), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), MGAM(26), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), SI(28), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UXS1(9)	40341344	392	171	375	118	112	71	49	83	76	1	0.123	1.000	1.000
272	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPS(6), CDS1(15), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CLC(3), CPT1B(14), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), ETNK1(3), GNPAT(19), GPD1(3), GPD2(11), LCAT(4), LGALS13(5), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(7), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB2(11), PLCG1(19), PLCG2(28), PPAP2A(2), PPAP2B(2), PPAP2C(3)	32486698	381	170	343	150	129	56	50	89	57	0	0.850	1.000	1.000
273	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(7), ACSS2(10), ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), G6PC2(3), GALM(3), GAPDH(2), GAPDHS(3), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	38703646	427	170	386	146	135	79	44	111	58	0	0.280	1.000	1.000
274	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(9), ACOX1(11), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP4A11(8), CYP4A22(13), DCI(4), ECHS1(4), EHHADH(15), GCDH(8), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), PECI(2)	33630441	389	170	355	118	103	74	63	98	51	0	0.0180	1.000	1.000
275	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(27), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(5), GNAI1(5), GNAQ(11), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAF1(16), RPS6KA3(16), SYT1(14)	22182296	292	169	249	97	116	69	24	47	36	0	0.109	1.000	1.000
276	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(7), IFNG(3), IFNGR1(8), IFNGR2(5), IKBKB(9), JAK2(55), LIN7A(7), NFKB1(11), NFKBIA(1), RB1(139), RELA(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), USH1C(15), WT1(32)	11761111	309	169	233	118	54	127	24	55	37	12	0.595	1.000	1.000
277	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), CSK(5), CTNNA1(28), CTNNA2(38), CTNNB1(120), PTK2(24), PXN(2), SRC(3), VCL(10)	12330090	274	168	216	107	63	79	34	69	28	1	0.725	1.000	1.000
278	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(14), CAPN1(2), CAPN2(10), CAPNS1(4), CAPNS2(4), CXCR3(5), EGF(8), EGFR(115), HRAS(4), ITGA1(12), ITGB1(13), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTK2(24), PXN(2), TLN1(23)	22698575	317	168	293	131	75	94	50	64	33	1	0.715	1.000	1.000
279	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(27), BAD(1), BAX(16), BCL2(2), BCL2A1(5), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CD40(7), CD40LG(10), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), IKBKE(9), LTA(1), NFKB1(11), NFKBIA(1), NGFR(5), NR3C1(11), NTRK1(17), PTPN13(23), RIPK1(7), SFRS2IP(3), TFG(8), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12), TRAF6(4)	28956784	319	165	281	147	66	78	31	69	74	1	1.000	1.000	1.000
280	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	66	CALR(2), CANX(5), CD4(4), CD74(3), CD8A(2), CD8B(4), CIITA(18), CREB1(3), CTSB(6), CTSL1(8), CTSS(4), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), HSP90AA1(9), HSP90AB1(4), HSPA5(5), IFI30(3), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(10), KIR2DL4(5), KIR2DS4(4), KIR3DL1(10), KIR3DL2(7), KIR3DL3(11), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LGMN(3), LTA(1), NFYA(5), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(15), RFXANK(1), RFXAP(5), TAP1(9), TAP2(16), TAPBP(6)	27307902	355	165	331	116	66	67	45	99	66	12	0.416	1.000	1.000
281	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(6), GTF2A1L(13), GTF2A2(1), GTF2B(12), GTF2E1(13), GTF2E2(1), GTF2F1(7), GTF2F2(1), GTF2H1(6), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(19), TAF1(32), TAF10(1), TAF12(4), TAF13(3), TAF1L(66), TAF2(20), TAF4(11), TAF4B(11), TAF5(13), TAF5L(3), TAF6(9), TAF6L(5), TAF7(3), TAF7L(14), TAF9(3), TAF9B(1), TBPL1(3), TBPL2(2)	25193065	292	164	259	87	79	52	32	80	48	1	0.168	1.000	1.000
282	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IL6(7), IL6R(8), IL6ST(15), JAK1(22), JAK2(55), JAK3(31), JUN(2), MAP2K1(12), MAPK3(4), PTPN11(41), RAF1(16), SHC1(14), SOS1(16), SRF(4), STAT3(10)	16194606	288	164	219	89	63	101	34	50	35	5	0.132	1.000	1.000
283	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), RB1(139), RBL1(21), TFDP1(10)	10864390	263	163	207	100	47	86	20	61	41	8	0.548	1.000	1.000
284	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(6), ABO(7), B3GALNT1(6), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(5), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALNT1(13), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT6(10), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GBGT1(1), GCNT2(26), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGX(4), PIGZ(6), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(16), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10), UGCG(9)	31239428	378	162	340	123	116	65	28	97	71	1	0.519	1.000	1.000
285	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), AGMAT(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH4A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), GAMT(6), GATM(2), GLUD1(4), GOT1(7), GOT2(2), MAOA(7), MAOB(9), NOS1(31), NOS3(23), OAT(4), ODC1(8), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(6), RARS(9), SMS(4)	29618054	368	161	332	117	124	60	47	81	56	0	0.131	1.000	1.000
286	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	32858197	381	161	340	124	119	79	39	97	47	0	0.129	1.000	1.000
287	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	32858197	381	161	340	124	119	79	39	97	47	0	0.129	1.000	1.000
288	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(8), ACAA1(7), ACAA2(4), ACADM(12), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), AOX1(15), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(4), ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HADHB(10), HIBADH(2), HIBCH(3), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), OXCT2(3), PCCA(17), PCCB(6)	30325901	324	161	293	82	96	58	41	67	61	1	0.00470	1.000	1.000
289	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(17), AGT(12), AGTR2(17), EDN1(3), EDNRA(9), EDNRB(19), EGF(8), EGFR(115), FOS(5), HRAS(4), JUN(2), MYC(5), NFKB1(11), PLCG1(19), PRKCA(8), RELA(10)	14190326	264	160	230	108	63	75	41	54	31	0	0.777	1.000	1.000
290	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(9), ASPH(15), COPS5(2), CREB1(3), EDN1(3), EP300(56), EPO(1), HIF1A(16), JUN(2), LDHA(14), NOS3(23), P4HB(6), VHL(105)	11126917	255	160	190	88	41	96	35	43	40	0	0.259	1.000	1.000
291	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(8), ACACA(36), ACACB(40), ACADM(12), ACAT1(7), ACAT2(9), ACSS1(7), ACSS2(10), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), HIBCH(3), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SUCLA2(9), SUCLG1(3), SUCLG2(1)	28010401	337	159	304	71	99	53	50	76	59	0	9.17e-05	1.000	1.000
292	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), DRD1(9), DRD2(9), DRD3(6), DRD5(14), HRH1(4), HRH2(16), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13)	16283720	315	158	277	110	128	61	38	54	33	1	0.0567	1.000	1.000
293	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ITPA(6), NME1(1), NT5C(1), NT5E(7), NT5M(3), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), RRM1(3), RRM2(5), TK1(2), TK2(3), TXNRD1(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UNG(3), UPB1(9), UPP1(5)	38761888	391	158	374	123	108	63	58	110	52	0	0.131	1.000	1.000
294	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(12), AKR1D1(9), ARSD(9), ARSE(4), CARM1(3), CYP11B1(17), CYP11B2(7), CYP19A1(11), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), WBSCR22(2)	33084863	348	157	329	106	90	64	41	88	65	0	0.0935	1.000	1.000
295	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	19	ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNAS(39), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12)	14468903	266	156	228	89	87	70	24	46	37	2	0.191	1.000	1.000
296	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	19	ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNAS(39), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12)	14468903	266	156	228	89	87	70	24	46	37	2	0.191	1.000	1.000
297	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(30), EEF1A2(8), EEF1B2(3), EEF1D(12), EEF1G(1), EEF2(7), EEF2K(11), EIF1AX(1), EIF2AK1(16), EIF2AK2(5), EIF2AK3(14), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF4A2(12), EIF4EBP2(4), EIF4G1(19), EIF4G3(19), EIF5(6), EIF5A(3), EIF5B(20), ETF1(13), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(23), PAIP1(7), SLC35A4(3)	29310599	313	156	268	82	71	72	29	70	71	0	0.0443	1.000	1.000
298	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(2), BTK(12), CALM2(1), CALM3(1), CD79A(6), CD79B(3), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK14(8), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24)	25300891	309	155	275	95	95	70	34	63	46	1	0.107	1.000	1.000
299	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(8), ADC(3), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EARS2(3), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GFPT2(12), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), GMPS(16), GNPNAT1(1), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSR(5), GSS(9), NADSYN1(4), NAGK(7), PPAT(8), QARS(14)	27172490	303	155	281	83	85	59	37	85	37	0	0.0280	1.000	1.000
300	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(36), ACACB(40), ACAT1(7), ACAT2(9), ACOT12(11), ACSS1(7), ACSS2(10), ACYP1(2), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PCK2(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4)	32074289	374	155	342	118	112	64	50	89	59	0	0.157	1.000	1.000
301	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(6), ADCY3(11), ADCY9(22), AK1(2), ARF1(1), ARF4(5), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ERO1L(4), GNAS(39), PDIA4(9), PLCG1(19), PLCG2(28), PRKCA(8), SEC61A1(10), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(18)	25093398	309	155	257	104	116	68	31	55	39	0	0.199	1.000	1.000
302	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG5(5), ALG6(5), ALG8(13), ALG9(8), B4GALT1(8), B4GALT2(7), B4GALT3(8), DAD1(3), DDOST(4), DHDDS(6), DPAGT1(14), DPM1(3), FUT8(11), GANAB(13), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), RFT1(3), RPN1(4), RPN2(7), ST6GAL1(3), STT3B(11)	27880274	325	154	293	112	84	57	34	88	62	0	0.819	1.000	1.000
303	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	29	ACTR2(2), ACTR3(5), ARHGAP1(3), ARHGAP4(7), ARHGAP6(11), ARHGEF1(15), ARHGEF11(24), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), BAIAP2(7), CFL1(2), DIAPH1(7), GSN(4), LIMK1(8), MYL2(2), MYLK(33), OPHN1(11), PIP5K1A(7), PIP5K1B(4), PPP1R12B(33), ROCK1(35), SRC(3), TLN1(23), VCL(10)	29742991	285	154	247	91	83	41	27	63	66	5	0.594	1.000	1.000
304	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), ESCO1(22), ESCO2(18), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), PRDX6(5), SH3GLB1(6), TAT(16), TPO(36)	22992331	317	153	275	103	110	53	37	69	47	1	0.189	1.000	1.000
305	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), DBH(9), DCT(22), DDC(5), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HGD(6), HPD(7), MAOA(7), MAOB(9), PNMT(3), TAT(16), TPO(36), TYR(12)	20736047	272	153	238	100	87	52	33	69	31	0	0.363	1.000	1.000
306	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), AOX1(15), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), HIBADH(2), HMGCL(1), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), PCCA(17), PCCB(6), SDS(3)	25203908	308	153	277	72	88	55	41	71	52	1	0.000551	1.000	1.000
307	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(4), ACY3(4), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(10), ASPA(8), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(12), HARS(6), HARS2(8), HDC(14), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), PRPS1(9), PRPS2(6), UROC1(10), WBSCR22(2)	26040708	300	152	278	92	87	61	42	74	36	0	0.0497	1.000	1.000
308	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(8), ABP1(4), ACADL(6), ACADM(12), ACADSB(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), MLYCD(4), SDS(3), SMS(4), UPB1(9)	20034021	296	150	271	79	87	47	45	80	37	0	0.00356	1.000	1.000
309	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(10), CDC7(25), CDK2(5), DIAPH2(28), GMNN(5), MCM10(12), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), PRIM1(5), RFC1(25), RFC2(3), RFC4(8), RFC5(8), RPA1(12), RPA2(1), RPA3(4), RPA4(6), UBA52(3), UBB(3), UBC(7)	33914887	349	148	301	107	68	62	47	93	78	1	0.369	1.000	1.000
310	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(8), AGXT2(9), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), ATP6V0C(1), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CPT1B(14), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), MAOA(7), MAOB(9), PEMT(2), PISD(8), PLCB2(11), PLCG1(19), PLCG2(28), PSPH(2), SARDH(17), SARS(6), SHMT1(7), SHMT2(5), TARS(10)	28265420	315	148	287	118	118	46	39	63	49	0	0.661	1.000	1.000
311	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(4), ALOX12B(6), ALOX15(5), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP2U1(5), CYP4A11(8), CYP4A22(13), CYP4F2(12), CYP4F3(11), DHRS4(1), EPHX2(5), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	26624421	287	148	263	97	92	39	36	74	45	1	0.452	1.000	1.000
312	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(11), CFL1(2), GNAQ(11), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), LIMK1(8), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), NOX1(4), PIK3C2G(21), PLCB1(23), PPP1R12B(33), PRKCA(8), PTK2(24), RAF1(16), ROCK2(20)	16889460	251	147	201	73	79	50	20	51	50	1	0.202	1.000	1.000
313	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AACS(9), AADAC(7), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ACSM1(10), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH7A1(8), ALDH9A1(4), BDH1(4), BDH2(2), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADH(2), HADHA(12), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), HSD3B7(3), ILVBL(9), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(8), PDHA2(17), PDHB(3), PLA1A(10), PPME1(2), PRDX6(5), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	27133702	310	147	280	100	102	56	39	75	38	0	0.0859	1.000	1.000
314	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(35), ATP4B(3), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ATP7A(13), ATP7B(16), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3), PPA2(5), SDHA(14), SDHB(3), SHMT1(7), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1)	26969228	296	147	267	93	90	52	38	62	54	0	0.127	1.000	1.000
315	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(7), BCR(12), BLNK(2), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8IP3(12), PAPPA(39), RAC1(2), RPS6KA1(9), RPS6KA3(16), SHC1(14), SOS1(16), SYK(8), VAV1(24), VAV2(20), VAV3(30)	20917090	290	146	258	71	83	61	36	75	34	1	0.00205	1.000	1.000
316	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(5), AKT1(11), AKT2(8), AKT3(8), DAG1(10), GNAQ(11), IKBKG(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PIK3CB(6), PITX2(2), PLD1(19), PLD2(10), PLD3(7), VN1R1(7)	28429292	314	146	306	103	103	60	39	70	41	1	0.187	1.000	1.000
317	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), ELK1(4), FPR1(8), GNA15(6), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NCF1(4), NCF2(10), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PAK1(11), PIK3C2G(21), PLCB1(23), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAC1(2), RAF1(16), RELA(10), SYT1(14)	25078048	296	145	273	104	100	51	33	70	41	1	0.385	1.000	1.000
318	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(8), ACACA(36), ACADL(6), ACADM(12), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), LDHA(14), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SDS(3), SUCLA2(9), SUCLG1(3), SUCLG2(1)	23384916	301	145	268	64	87	52	43	67	52	0	0.000235	1.000	1.000
319	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(36), ACAT1(7), ACAT2(9), ACYP1(2), ADH5(7), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHA(14), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4)	25038141	315	144	282	104	92	62	40	75	46	0	0.253	1.000	1.000
320	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(27), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), FADD(1), FAS(9), FASLG(3), GZMB(5), IKBKG(2), JUN(2), MAP3K1(21), MAP3K14(6), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), PARP1(17), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(3), TRAF1(7), TRAF2(8)	23844461	282	143	242	86	65	54	33	56	73	1	0.280	1.000	1.000
321	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(8), F12(5), F13B(12), F2(10), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), LPA(30), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10), SERPINF2(4), VWF(36)	24266775	325	143	295	129	81	61	48	83	49	3	0.823	1.000	1.000
322	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(10), AARS2(13), CARS(11), CARS2(6), DARS(5), DARS2(8), EARS2(3), EPRS(27), FARS2(7), FARSA(6), FARSB(12), GARS(8), HARS(6), HARS2(8), IARS(10), IARS2(19), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), MTFMT(1), NARS(5), NARS2(11), PARS2(2), QARS(14), RARS(9), RARS2(10), SARS(6), SARS2(4), TARS(10), TARS2(10), VARS(7), VARS2(9), WARS(4), WARS2(7), YARS(4), YARS2(7)	36535307	328	143	319	84	103	43	44	88	50	0	0.0279	1.000	1.000
323	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(11), AKT2(8), AKT3(8), ARHGEF11(24), BCL2(2), CDC42(3), DLG4(10), GNA13(3), IKBKG(2), LPA(30), MAP3K1(21), MAP3K5(16), MAPK8(17), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PI3(3), PIK3CB(6), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RDX(16), ROCK1(35), ROCK2(20), SERPINA4(10), SRF(4)	32302569	363	143	338	112	108	54	33	99	64	5	0.387	1.000	1.000
324	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(11), ATF1(6), CDC42(3), CREB1(3), CREB3(6), CREB5(8), DUSP1(7), DUSP10(6), EEF2K(11), ELK1(4), IL1R1(7), MAP2K3(11), MAP2K6(5), MAP3K10(11), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MKNK1(4), MKNK2(7), MYEF2(14), NFKB1(11), NR2C2(11), SRF(4), TRAF6(4)	21860849	265	143	236	73	69	46	40	60	49	1	0.0445	1.000	1.000
325	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(8), AGXT2(9), AKR1B10(3), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), GNMT(3), HSD3B7(3), MAOA(7), MAOB(9), PEMT(2), PHGDH(3), PIPOX(9), PISD(8), PSAT1(7), PSPH(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SARDH(17), SARS(6), SARS2(4), SDS(3), SHMT1(7), SHMT2(5), TARS(10), TARS2(10)	29237069	303	142	286	109	110	39	39	72	43	0	0.511	1.000	1.000
326	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(28), GABBR1(20), GPRC5A(5), GPRC5B(4), GPRC5C(10), GPRC5D(3), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM7(36), GRM8(29)	13402320	257	141	223	103	104	34	32	53	34	0	0.630	1.000	1.000
327	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(8), ABP1(4), ACADM(12), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HIBCH(3), MLYCD(4), SMS(4), SRM(1), UPB1(9)	18476994	263	141	239	77	76	42	41	70	34	0	0.0364	1.000	1.000
328	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ATP6V0C(1), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADHA(12), PLOD1(8), PLOD2(10), PLOD3(7), SDS(3), SHMT1(7), SHMT2(5), TMLHE(6)	23744664	279	141	251	71	81	53	38	64	43	0	0.00219	1.000	1.000
329	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(6), CHUK(27), ELK1(4), FOS(5), IKBKB(9), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), PPARA(7), RELA(10), TIRAP(5), TLR10(14), TLR2(12), TLR3(15), TLR4(18), TLR6(14), TLR7(18), TLR9(16), TOLLIP(5), TRAF6(4)	24124288	296	141	283	79	76	57	27	86	48	2	0.0458	1.000	1.000
330	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(8), EGFR(115), MAP2K1(12), MAP3K1(21), MAPK14(8), NCOR2(44), RARA(6), RXRA(8), THRA(6), THRB(14)	11147728	242	140	207	92	57	70	36	46	33	0	0.688	1.000	1.000
331	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(3), B4GALT1(8), B4GALT2(7), G6PC(5), G6PC2(3), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANC(9), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), HSD3B7(3), LALBA(2), LCT(46), MGAM(26), PFKL(7), PFKM(5), PFKP(16), PGM1(10), PGM3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), UGP2(12)	24841549	283	139	272	100	103	43	31	77	29	0	0.324	1.000	1.000
332	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(7), ACAA2(4), ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1B10(3), AKR1C4(12), AKR1D1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), HSD3B7(3), LIPA(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SLC27A5(9), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2)	21633822	261	139	235	74	66	55	38	70	31	1	0.0322	1.000	1.000
333	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(7), CDC42(3), CREB1(3), DAXX(18), DDIT3(5), ELK1(4), GRB2(11), HRAS(4), HSPB2(3), MAP2K6(5), MAP3K1(21), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MYC(5), PLA2G4A(16), RAC1(2), RIPK1(7), RPS6KA5(13), SHC1(14), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8)	24221369	290	137	263	88	85	66	28	64	46	1	0.189	1.000	1.000
334	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(8), B4GALT2(7), FBP2(5), G6PC(5), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANAB(13), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), LALBA(2), LCT(46), MGAM(26), PFKM(5), PFKP(16), PGM1(10), PGM3(7)	21134447	248	136	239	93	90	44	27	61	26	0	0.538	1.000	1.000
335	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CYP2C19(12), CYP2C9(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), HADHA(12), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3)	21011582	281	136	247	82	71	62	37	68	42	1	0.0906	1.000	1.000
336	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(3), CREBBP(81), EP300(56), NCOA3(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RARA(6), RXRA(8)	14144361	213	135	187	87	52	56	28	41	36	0	0.754	1.000	1.000
337	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(10), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(8), ADSSL1(6), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), ASRGL1(1), ASS1(5), CAD(23), CRAT(11), DARS(5), DARS2(8), DDO(6), DLAT(10), DLD(4), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), NARS2(11), PC(16), PDHA1(8), PDHA2(17), PDHB(3)	25476532	280	135	263	109	96	39	41	64	40	0	0.747	1.000	1.000
338	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(12), ALAS2(12), BLVRA(2), BLVRB(2), COX10(6), COX15(8), CP(24), CPOX(4), EARS2(3), EPRS(27), FECH(4), FTH1(1), FTMT(8), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), MMAB(2), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UROD(3), UROS(5)	28229195	298	135	269	72	67	55	39	80	57	0	0.0271	1.000	1.000
339	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(27), CREBBP(81), EP300(56), FADD(1), HDAC3(3), IKBKB(9), IKBKG(2), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	15327977	219	135	188	81	59	66	23	36	35	0	0.463	1.000	1.000
340	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(4), BFAR(9), BRAF(125), CAMP(1), CREB1(3), CREB3(6), CREB5(8), MAPK1(3), RAF1(16), SRC(3), TERF2IP(4)	6867563	182	135	103	61	19	58	17	72	16	0	0.428	1.000	1.000
341	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(8), ARG1(2), ARG2(6), ASL(5), ASS1(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), EPRS(27), GAMT(6), GATM(2), GLUD1(4), GLUD2(22), GOT1(7), GOT2(2), LAP3(4), NOS1(31), NOS3(23), OAT(4), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(2), PRODH(5), RARS(9), RARS2(10)	23926762	279	134	257	86	89	38	41	69	42	0	0.175	1.000	1.000
342	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), PON1(12)	19550871	255	133	246	77	98	42	22	63	28	2	0.0872	1.000	1.000
343	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GAPDHS(3), GCK(6), GOT1(7), GOT2(2), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHAL6B(7), LDHB(8), LDHC(4), MDH1(8), MDH2(3), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PKLR(12), PKM2(4), TNFAIP1(4), TPI1(3)	28154287	295	133	268	122	113	49	27	67	39	0	0.849	1.000	1.000
344	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ACY1(6), ADC(3), AGMAT(7), ALDH18A1(8), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), ASS1(5), CPS1(39), GATM(2), MAOA(7), MAOB(9), NAGS(6), ODC1(8), OTC(17), SAT1(5), SAT2(2), SMS(4), SRM(1)	20265396	244	133	217	71	73	50	31	59	31	0	0.0570	1.000	1.000
345	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PLCG1(19), PTPN6(4), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20)	14736094	223	132	182	75	54	70	21	40	34	4	0.597	1.000	1.000
346	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(8), EGFR(115), ERBB3(32), NRG1(33), UBE2D1(1)	7284913	189	132	159	67	43	69	26	35	16	0	0.334	1.000	1.000
347	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(5), CDKN1B(6), CKS1B(2), CUL1(17), NEDD8(1), RB1(139), RBX1(1), SKP2(3), TFDP1(10), UBE2M(2)	6024134	192	132	139	73	31	70	10	38	35	8	0.660	1.000	1.000
348	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(18), CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), SKP2(3), TFDP1(10)	6148005	200	132	145	78	34	73	10	44	31	8	0.619	1.000	1.000
349	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(27), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), GAS2(4), LMNA(1), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), SPTAN1(30), TNFRSF10A(8), TNFRSF10B(8), TNFRSF25(2), TNFSF10(3), TNFSF12(2), TRAF2(8)	22591935	240	131	209	79	57	52	27	54	49	1	0.485	1.000	1.000
350	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), NOS1(31), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), SYT1(14)	16989570	238	131	222	100	85	43	22	51	36	1	0.781	1.000	1.000
351	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(8), PDHA2(17), PDHB(3), SDHB(3), SDS(3)	17956584	242	130	215	68	72	46	34	60	30	0	0.0170	1.000	1.000
352	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IL2(5), IL2RA(6), IL2RB(5), IL2RG(9), JAK1(22), JAK3(31), JUN(2), LCK(9), MAP2K1(12), MAPK3(4), MAPK8(17), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8)	15861493	237	130	195	59	59	56	24	46	50	2	0.0472	1.000	1.000
353	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(4), ALOX15(5), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(11), EPX(14), GGT1(11), LPO(10), LTA4H(2), MPO(17), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13), TPO(36)	18683209	227	130	207	73	93	28	27	42	37	0	0.168	1.000	1.000
354	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(7), ACAA2(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AKR1C4(12), AKR1D1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), SOAT2(4), SRD5A1(2), SRD5A2(2)	15991332	223	129	198	52	54	51	31	59	27	1	0.00182	1.000	1.000
355	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(8), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), GMPS(16), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSS(9), NADSYN1(4), PPAT(8), QARS(14)	22869210	250	129	228	64	65	53	31	70	31	0	0.0209	1.000	1.000
356	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(14), ADCY1(27), CAP1(5), CCNB1(8), CDC25C(6), GNAI1(5), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), MAPK1(3), MAPK3(4), MYT1(25), PIN1(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KA1(9), SRC(3)	13313794	193	129	170	56	84	37	21	36	15	0	0.0166	1.000	1.000
357	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(6), CALM2(1), CALM3(1), CRKL(5), GNAQ(11), GRB2(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), PAK1(11), PLCG1(19), PRKCA(8), PTK2B(13), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SRC(3), SYT1(14)	18583106	236	129	206	80	56	56	25	65	33	1	0.541	1.000	1.000
358	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(15), POLA2(6), POLB(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLG(9), POLG2(4), POLH(16), POLK(11), POLL(2), POLM(12), POLQ(42), PRIM1(5), PRIM2(3), REV1(16), REV3L(45), RFC5(8)	27921628	285	128	260	87	65	42	38	81	57	2	0.457	1.000	1.000
359	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ABP1(4), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), AOC2(12), AOC3(10), ASPA(8), CNDP1(7), DDC(5), HAL(12), HARS(6), HDC(14), HNMT(11), MAOA(7), MAOB(9), PRPS1(9), PRPS2(6)	16485179	221	126	197	55	66	46	31	56	22	0	0.00259	1.000	1.000
360	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM2(1), CALM3(1), CHUK(27), EGR2(16), EGR3(6), GNAQ(11), MAP3K1(21), MYC(5), NFATC2(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), SYT1(14), VIP(3), VIPR2(11)	17855655	227	126	205	73	70	50	24	44	39	0	0.182	1.000	1.000
361	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(15), AGT(12), AGTR1(14), AGTR2(17), CMA1(1), COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), REN(10)	18109524	216	125	205	72	54	30	29	60	43	0	0.100	1.000	1.000
362	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(12), CALCRL(9), CD97(12), CRHR1(6), CRHR2(6), ELTD1(14), EMR1(17), EMR2(11), GHRHR(2), GIPR(1), GLP1R(11), GLP2R(10), GPR64(19), LPHN1(20), LPHN2(30), LPHN3(30), SCTR(6), VIPR1(7), VIPR2(11)	18379554	239	125	235	99	79	37	20	74	29	0	0.764	1.000	1.000
363	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(3), ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), FUK(9), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), HSD3B7(3), KHK(4), LHPP(6), MPI(4), MTMR1(13), MTMR2(8), MTMR6(11), PFKFB1(14), PFKFB2(5), PFKFB3(3), PFKFB4(5), PFKL(7), PFKM(5), PFKP(16), PGM2(4), PHPT1(2), PMM1(5), PMM2(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SORD(2), TPI1(3), TSTA3(1)	25000486	252	125	234	95	97	36	26	61	32	0	0.575	1.000	1.000
364	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(81), EP300(56), LPL(12), NCOA1(15), NCOA2(23), PPARG(4), RXRA(8)	12259823	199	125	178	83	50	56	28	37	28	0	0.735	1.000	1.000
365	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(5), NFYB(2), NFYC(10), RB1(139), SP1(7), SP3(13)	4757427	176	125	123	59	23	74	10	37	24	8	0.121	1.000	1.000
366	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), P4HB(6), SLC23A1(10), SLC23A2(18), SLC2A1(7), SLC2A3(13)	17893323	201	125	188	77	52	26	31	51	41	0	0.268	1.000	1.000
367	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CCR5(11), CD3D(5), CD3E(2), CXCR3(5), ETV5(15), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), JAK2(55), JUN(2), MAP2K6(5), MAPK14(8), MAPK8(17), STAT4(13), TYK2(5)	12667138	193	124	168	78	31	69	25	47	18	3	0.818	1.000	1.000
368	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TAT(16), TPO(36)	14444897	203	124	177	62	84	28	25	38	28	0	0.0672	1.000	1.000
369	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(19), EGF(8), EGFR(115), HGS(10), RAB5A(4), TF(21), TFRC(7)	8917235	184	123	158	72	35	67	25	37	19	1	0.409	1.000	1.000
370	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(5), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GCNT1(9), GCNT3(6), GCNT4(14), OGT(10), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(6)	21606286	249	123	238	96	76	40	34	66	33	0	0.857	1.000	1.000
371	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(25), C5(25), C6(27), C7(11), ICAM1(4), IL1A(1), IL6(7), IL8(6), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELP(15), TNF(2), VCAM1(15)	16334425	210	123	200	73	69	29	21	50	40	1	0.343	1.000	1.000
372	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), DAG1(10), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFAT5(6), PDE6A(14), PDE6B(11), PDE6C(12), PDE6D(2), SLC6A13(10), TF(21)	23328549	267	123	265	89	83	48	29	61	45	1	0.193	1.000	1.000
373	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(7), ACAT2(9), ACOT11(9), ACYP1(2), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), FN3K(1), GCDH(8), HADHA(12), ITGB1BP3(1), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3)	17500620	214	122	190	71	53	43	28	51	38	1	0.407	1.000	1.000
374	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(27), IFNA1(8), IFNB1(6), IKBKB(9), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL1RN(7), IL6(7), IRAK1(6), IRAK2(11), IRAK3(11), JUN(2), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2), TOLLIP(5), TRAF6(4)	19825512	242	122	224	68	76	43	25	64	34	0	0.0748	1.000	1.000
375	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(12), DLG4(10), EPHB2(16), F2(10), F2RL1(8), F2RL2(8), JUN(2), MAP2K5(6), MAPK1(3), MAPK7(6), MAPK8(17), MYEF2(14), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RAF1(16), RASAL1(9), SRC(3), TEC(10), VAV1(24)	18732351	234	122	218	86	79	52	28	50	25	0	0.548	1.000	1.000
376	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(15), AGT(12), AGTR1(14), AGTR2(17), ANPEP(19), CMA1(1), CPA3(5), CTSA(6), CTSG(5), ENPEP(24), LNPEP(23), MAS1(3), MME(27), NLN(13), REN(10), THOP1(6)	14399905	214	121	194	54	52	38	26	60	38	0	0.0172	1.000	1.000
377	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(81), EP300(56), ESR1(21), MAPK1(3), MAPK3(4), PELP1(11), SRC(3)	10143037	179	121	157	75	46	47	21	34	31	0	0.809	1.000	1.000
378	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(7), IL6R(8), JAK1(22), JAK2(55), JAK3(31), PIAS3(10), PTPRU(24), REG1A(8), SRC(3), STAT3(10)	10374426	180	121	148	66	56	57	23	21	19	4	0.556	1.000	1.000
379	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(14), AZIN1(3), BTG1(2), CBX3(7), CLOCK(24), CRY1(17), CRY2(5), DNAJA1(5), EIF4G2(16), ETV6(11), GFRA1(17), GSTM3(6), GSTP1(1), HERPUD1(3), HSPA8(13), IDI1(4), KLF9(1), MYF6(7), NCKAP1(17), NCOA4(9), NR1D2(10), PER1(13), PER2(9), PIGF(1), PPP1R3C(6), PPP2CB(4), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(8), TUBB3(10), UCP3(3), UGP2(12), VAPA(2), ZFR(21)	24979942	286	120	243	76	76	42	25	78	62	3	0.167	1.000	1.000
380	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(7), ARSB(10), FUCA1(7), FUCA2(5), GALNS(6), GBA(4), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE(11), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NAGLU(6), NEU1(6), NEU2(6), NEU3(2), SPAM1(13)	21886047	248	120	228	85	78	58	23	60	29	0	0.307	1.000	1.000
381	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(7), CDK7(3), ERCC3(19), GTF2A2(1), GTF2B(12), GTF2E1(13), GTF2E2(1), GTF2F2(1), GTF2H1(6), GTF2H4(3), ILK(3), MNAT1(4), POLR1A(15), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3B(14), POLR3D(5), POLR3E(13), POLR3H(2), POLR3K(2), TAF12(4), TAF13(3), TAF5(13), TAF6(9), TAF7(3), TAF9(3), TBP(2)	24399525	217	120	200	79	60	36	28	50	43	0	0.716	1.000	1.000
382	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(14), EPHA4(26), EPHB1(38), FYN(17), ITGA1(12), ITGB1(13), L1CAM(17), LYN(13), RAP1B(2), SELP(15)	10545769	167	118	153	56	52	34	31	31	18	1	0.135	1.000	1.000
383	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(12), ACO1(12), ACO2(7), CLYBL(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), OGDHL(16), PC(16), PCK1(6), PCK2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1)	19904306	187	118	175	68	61	25	27	49	25	0	0.506	1.000	1.000
384	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(3), ENPP7(3), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(6), SGMS2(8), SGPP1(8), SGPP2(6), SMPD1(10), SMPD2(3), SMPD3(4), SMPD4(9), SPHK1(3), SPHK2(5), SPTLC1(12), SPTLC2(9), UGCG(9), UGT8(12)	21682977	235	118	223	87	72	41	34	53	34	1	0.443	1.000	1.000
385	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6)	16773466	208	117	185	76	44	50	26	57	30	1	0.632	1.000	1.000
386	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(13), FOS(5), GRB2(11), HRAS(4), IL3(6), JAK2(55), MAP2K1(12), MAPK3(4), PTPN6(4), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20)	11504029	190	117	150	60	46	63	17	29	31	4	0.421	1.000	1.000
387	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(10), BIRC2(7), BIRC3(18), CASP3(4), CASP8(20), CFLAR(3), FADD(1), IKBKG(2), JUN(2), MAP3K3(8), MAP3K7(9), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NR2C2(11), RALBP1(8), RIPK1(7), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	16764403	195	116	169	61	43	54	16	40	42	0	0.303	1.000	1.000
388	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(11), ADRBK2(11), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CLCA1(14), CLCA2(11), CLCA4(15), CNGA3(17), CNGA4(14), CNGB1(15), GNAL(5), GUCA1A(3), GUCA1B(4), GUCA1C(3), PDC(4), PDE1C(19), PRKACA(2), PRKACB(5), PRKACG(9), PRKG1(18), PRKG2(12), PRKX(3)	21422132	228	115	218	107	64	34	31	64	35	0	0.978	1.000	1.000
389	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(2), DLAT(10), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), PC(16), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PDK1(7), PDK2(9), PDK3(6), PDK4(6), PDP2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1)	19541091	203	115	186	81	64	33	26	51	29	0	0.761	1.000	1.000
390	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(27), FADD(1), IKBKB(9), IKBKG(2), IL1A(1), IL1R1(7), IRAK1(6), MAP3K1(21), MAP3K14(6), MAP3K7(9), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TLR4(18), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	16109182	193	115	178	62	46	55	18	44	30	0	0.253	1.000	1.000
391	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), LTA(1), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNFAIP3(42), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12)	15452709	195	115	173	64	52	55	20	34	34	0	0.206	1.000	1.000
392	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(16), DDX20(7), E2F4(2), ETS1(10), ETS2(5), ETV3(5), FOS(5), HDAC2(8), HDAC5(14), HRAS(4), JUN(2), NCOR2(44), RBL1(21), RBL2(24), SIN3A(28), SIN3B(10)	17145408	210	114	183	80	55	41	20	42	52	0	0.872	1.000	1.000
393	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(4), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(22), JAK2(55), JAK3(31), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), TYK2(5)	12278247	182	114	148	65	38	62	14	34	30	4	0.803	1.000	1.000
394	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(24), CALM2(1), CALM3(1), CAPN2(10), CAPNS1(4), CAPNS2(4), EP300(56), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SYT1(14)	15300958	173	114	153	73	50	35	22	32	34	0	0.825	1.000	1.000
395	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(22), JAK2(55), JAK3(31), PIAS1(4), PIAS3(10), PTPRU(24), REG1A(8), SOAT1(6)	9167754	162	114	136	58	47	56	17	19	19	4	0.511	1.000	1.000
396	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(10), F2R(11), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), PLA2G4A(16), PLCB1(23), PRKCA(8), PTGS1(10), PTK2(24), RAF1(16), SRC(3), SYK(8), TBXAS1(13)	16933598	199	113	179	83	68	43	27	40	21	0	0.803	1.000	1.000
397	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(10), ABAT(8), ADSL(13), ADSS(8), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), CAD(23), CRAT(11), DARS(5), DDO(6), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), PC(16)	17503229	190	112	176	73	64	24	30	47	25	0	0.674	1.000	1.000
398	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(12), AKR1D1(9), ARSB(10), ARSD(9), ARSE(4), CYP11B1(17), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10)	18613178	201	112	182	55	69	30	23	39	40	0	0.0221	1.000	1.000
399	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(10), DYRK1B(14), GLI2(28), GLI3(44), GSK3B(17), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SHH(3), SMO(13), SUFU(5)	10475187	169	112	154	71	60	38	14	30	27	0	0.691	1.000	1.000
400	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(27), GNAS(39), GNB1(3), GNGT1(1), PPP2CA(3), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	10150157	159	111	134	47	68	31	8	31	21	0	0.118	1.000	1.000
401	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(13), ITGB3(16), PTK2(24), PXN(2), RAC1(2), SPTAN1(30), SRC(3), TLN1(23)	19208856	187	111	180	96	60	31	23	45	26	2	0.997	1.000	1.000
402	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C8B(23), C9(12), MASP1(23)	16668527	202	110	192	65	59	26	22	52	41	2	0.515	1.000	1.000
403	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(75), MAP2(60), PPP1CA(2), PPP2CA(3), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6), PRKCE(6)	12641543	175	109	151	56	36	40	23	39	37	0	0.395	1.000	1.000
404	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(11), CHIT1(12), CMAS(9), CTBS(6), CYB5R1(4), CYB5R3(2), GFPT1(6), GFPT2(12), GNE(8), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NAGK(7), NANS(2), NPL(4), PGM3(7), PHPT1(2), RENBP(3), UAP1(6)	19707803	200	109	191	56	74	36	24	38	28	0	0.0434	1.000	1.000
405	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(12), BAIAP2(7), CASP1(6), CASP3(4), CASP7(3), CASP8(20), GAPDH(2), INSR(21), ITCH(7), MAGI1(31), MAGI2(32), RERE(15), WWP1(21), WWP2(9)	16031074	190	109	176	70	53	31	28	38	39	1	0.659	1.000	1.000
406	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(12), EEA1(19), GRASP(3), GSK3A(6), GSK3B(17), LYN(13), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PLCG1(19), PRKCE(6), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(9), VAV2(20)	16443107	190	108	173	63	57	39	26	37	30	1	0.328	1.000	1.000
407	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(16), FYN(17), LRP8(5), RELN(95), VLDLR(15)	9756132	156	107	129	50	41	38	17	39	21	0	0.116	1.000	1.000
408	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(27), ARHGDIB(5), BIRC2(7), BIRC3(18), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), GZMB(5), LMNA(1), LMNB1(11), LMNB2(3), PRF1(8)	13214043	162	106	135	55	30	36	14	44	38	0	0.763	1.000	1.000
409	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), TNFAIP3(42), TRAF3(12), TRAF6(4)	12705040	167	106	149	51	41	47	16	32	31	0	0.193	1.000	1.000
410	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(19), GTF2A1(6), GTF2B(12), GTF2E1(13), GTF2F1(7), HDAC3(3), NCOA1(15), NCOA2(23), NCOA3(21), NCOR2(44), POLR2A(14), RARA(6), RXRA(8), TBP(2)	16178934	193	106	169	85	59	29	29	37	39	0	0.975	1.000	1.000
411	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(6), CASP2(8), CHUK(27), CRADD(4), IKBKB(9), IKBKG(2), JUN(2), LTA(1), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP4K2(6), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNF(2), TNFRSF1A(4), TRAF2(8)	15496295	184	106	168	63	53	43	19	42	27	0	0.375	1.000	1.000
412	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(10), CARS(11), DARS(5), EPRS(27), FARS2(7), GARS(8), HARS(6), IARS(10), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), NARS(5), QARS(14), RARS(9), SARS(6), TARS(10), WARS(4), WARS2(7), YARS(4)	22744531	192	105	186	44	58	26	28	52	28	0	0.0199	1.000	1.000
413	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12), MASP1(23), MASP2(10), MBL2(3)	17012866	192	104	183	67	54	22	21	51	42	2	0.740	1.000	1.000
414	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(24), CPOX(4), EPRS(27), FECH(4), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UROD(3), UROS(5)	18782028	175	104	156	46	43	30	23	40	39	0	0.187	1.000	1.000
415	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	12	ARHGEF1(15), GNA12(7), GNA13(3), GNAQ(11), GNB1(3), GNGT1(1), MYL2(2), MYLK(33), PLCB1(23), PPP1R12B(33), PRKCA(8), ROCK1(35)	12436250	174	103	142	57	41	27	15	39	48	4	0.725	1.000	1.000
416	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), GCK(6), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), KHK(4), MPI(4), PFKFB1(14), PFKFB3(3), PFKFB4(5), PFKM(5), PFKP(16), PMM1(5), PMM2(2), SORD(2), TPI1(3)	16348521	170	102	157	61	64	24	16	45	21	0	0.450	1.000	1.000
417	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(16), ALDOC(3), DERA(4), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKL(7), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1(9), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TALDO1(4), TKT(7), TKTL1(8), TKTL2(15)	15779471	174	102	162	58	58	30	25	46	15	0	0.168	1.000	1.000
418	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(8), CARM1(3), CBS(4), CTH(6), GGT1(11), HEMK1(1), LCMT1(1), LCMT2(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), METTL2B(3), METTL6(8), PAPSS1(5), PAPSS2(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SCLY(12), SEPHS1(7), SEPHS2(5), WBSCR22(2)	16478016	167	102	156	51	42	27	23	41	34	0	0.196	1.000	1.000
419	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	16	CALM2(1), CALM3(1), CDKN1A(2), GNAQ(11), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SP1(7), SP3(13), SYT1(14)	13023936	138	101	124	59	43	33	13	25	24	0	0.839	1.000	1.000
420	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(8), AMD1(4), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTAP(3), MTFMT(1), MTR(14), SRM(1), TAT(16)	14116545	174	101	161	57	66	21	26	33	27	1	0.248	1.000	1.000
421	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(7), ABP1(4), AOC2(12), AOC3(10), CES1(14), CES7(1), ESCO1(22), ESCO2(18), LIPA(3), MYST3(34), MYST4(33), NAT6(2), PLA1A(10), PNPLA3(6), PPME1(2), PRDX6(5), SH3GLB1(6)	16351661	189	101	172	72	50	35	24	49	30	1	0.702	1.000	1.000
422	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(44), APOA1(3), APOA4(6), APOC1(1), APOC2(2), APOE(1), CETP(12), CYP7A1(14), DGAT1(5), HMGCR(7), LCAT(4), LDLR(11), LIPC(6), LPL(12), LRP1(53), SCARB1(4), SOAT1(6)	18004821	191	101	181	71	65	30	25	48	23	0	0.546	1.000	1.000
423	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), HAL(12)	14785991	161	100	152	58	50	29	19	38	25	0	0.631	1.000	1.000
424	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(27), ADRB2(3), GNAS(39), PLCE1(34), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAP2B(3)	9500104	141	100	121	34	57	31	7	32	14	0	0.00902	1.000	1.000
425	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(22), JAK2(55), JAK3(31), MAPK1(3), MAPK3(4), STAT3(10), TYK2(5)	7857135	130	100	103	49	27	56	10	19	14	4	0.769	1.000	1.000
426	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(15), DRD1(9), DRD2(9), GRM1(37), PLCB1(23), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	10797443	147	99	133	54	50	35	7	33	22	0	0.565	1.000	1.000
427	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(16), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPHN(18), NSF(4), SRC(3), UBQLN1(6)	8469740	155	99	140	47	40	22	17	51	25	0	0.205	1.000	1.000
428	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG3(4), ATG5(10), ATG7(1), BECN1(3), GABARAPL1(1), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(29), PIK3R4(21), PRKAA1(9), PRKAA2(20), ULK2(14), ULK3(3)	13352843	166	99	146	48	26	42	23	51	23	1	0.206	1.000	1.000
429	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BAX(16), BCL2(2), CASP8(20), CYCS(1), FADD(1), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFKB1(11), NSMAF(13), RAF1(16), RELA(10), RIPK1(7), SMPD1(10), TNFRSF1A(4), TRAF2(8)	13359013	177	98	151	49	54	30	19	34	39	1	0.107	1.000	1.000
430	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(27), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP7(3), CASP8(20), CASP9(6), DFFA(6), DFFB(2), GZMB(5), PRF1(8), SCAP(9), SREBF1(8), SREBF2(10)	11809219	140	98	120	47	28	25	16	38	33	0	0.596	1.000	1.000
431	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(12), ACO2(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), PC(16), PCK1(6), SDHA(14), SDHB(3), SUCLA2(9), SUCLG1(3), SUCLG2(1)	13467799	128	96	119	52	38	19	18	34	19	0	0.745	1.000	1.000
432	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(5), ALOX5(12), CYP1A2(11), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), HSD3B7(3), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	16709635	177	96	169	62	62	35	18	48	13	1	0.325	1.000	1.000
433	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), B4GALNT1(13), GLB1(9), HEXA(4), HEXB(5), LCT(46), SLC33A1(10), ST3GAL1(3), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10)	11266988	151	96	129	53	53	33	13	32	20	0	0.470	1.000	1.000
434	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME3(8), PGK1(3), PGK2(10), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TKTL1(8), TKTL2(15), TPI1(3)	13626489	150	96	140	58	45	22	17	49	17	0	0.667	1.000	1.000
435	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), DDOST(4), DPAGT1(14), DPM1(3), FUT8(11), MAN1A1(14), MAN1B1(7), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), RPN1(4), RPN2(7), ST6GAL1(3)	12685384	151	96	136	52	43	33	17	30	28	0	0.679	1.000	1.000
436	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR7(7), CD28(5), CD4(4), CXCR3(5), CXCR4(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18R1(16), IL2(5), IL4(5), IL4R(6), TGFB1(2), TGFB2(10), TGFB3(2)	14143712	159	96	145	62	34	37	21	45	21	1	0.641	1.000	1.000
437	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1(9), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TAL1(3), TALDO1(4), TKT(7)	13375468	143	96	130	47	47	26	17	41	12	0	0.216	1.000	1.000
438	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(7), CREBBP(81), DFFA(6), DFFB(2), GZMA(11), GZMB(5), HMGB2(2), NME1(1), PRF1(8), SET(6)	7165757	130	96	119	51	34	31	14	31	20	0	0.666	1.000	1.000
439	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(3), IFNGR1(8), JAK1(22), JAK2(55), PTPRU(24), REG1A(8), STAT1(17)	7960983	139	96	118	47	41	50	8	21	14	5	0.484	1.000	1.000
440	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(27), ADRB2(3), CFTR(21), GNAS(39), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SLC9A3R1(3)	8463733	128	95	108	35	51	27	6	29	15	0	0.0556	1.000	1.000
441	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(7), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GCNT2(26), ST3GAL6(16), ST8SIA1(10)	9215862	142	95	131	33	48	20	11	41	21	1	0.0228	1.000	1.000
442	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(11), CD2(7), CD3D(5), CD3E(2), CD4(4), CXCR3(5), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), JAK2(55), STAT4(13), TYK2(5)	10007909	138	95	117	55	17	56	19	32	11	3	0.770	1.000	1.000
443	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(10), SMPD2(3), SPTLC1(12), SPTLC2(9), UGCG(9)	15097703	165	94	155	62	50	30	22	43	20	0	0.538	1.000	1.000
444	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), XYLB(6)	17778277	187	94	169	46	33	30	23	55	46	0	0.143	1.000	1.000
445	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(11), GRB2(11), IL2RG(9), IL4(5), IL4R(6), IRS1(21), JAK1(22), JAK3(31), RPS6KB1(9), SHC1(14), STAT6(4)	9532244	143	94	112	37	34	32	17	21	37	2	0.177	1.000	1.000
446	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(4), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(7), EDN1(3), EDNRA(9), EDNRB(19), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(16), PRL(4), PTGDR(9), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	14267644	160	93	151	58	59	18	14	46	23	0	0.566	1.000	1.000
447	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(27), CREM(10), FHL5(11), FSHB(6), FSHR(19), GNAS(39), XPO1(9)	6175525	121	92	95	32	50	29	9	24	9	0	0.0841	1.000	1.000
448	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(11), F13A1(15), F2(10), F2R(11), FGA(23), FGB(6), FGG(7), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10)	9577865	148	92	137	52	41	26	25	33	23	0	0.490	1.000	1.000
449	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE(11), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), NAGLU(6), SPAM1(13)	13451262	166	92	148	54	52	37	15	43	19	0	0.279	1.000	1.000
450	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), GLCE(8), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), NDST1(10), NDST2(10), NDST3(19), NDST4(13)	13840841	152	92	147	57	58	29	13	34	18	0	0.646	1.000	1.000
451	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(1), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), ILVBL(9), PANK1(7), PANK2(1), PANK3(7), PANK4(8), PPCS(4), UPB1(9), VNN1(13)	11358523	151	92	141	46	32	29	28	44	17	1	0.132	1.000	1.000
452	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), HDAC5(14), MEF2A(7), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(5), PPP3CB(11), PPP3CC(7), SLC2A4(8), SYT1(14), YWHAH(5)	13353528	150	92	142	70	48	32	11	33	26	0	0.952	1.000	1.000
453	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(5), CHAT(17), DBH(9), DDC(5), GAD1(17), GAD2(15), HDC(14), MAOA(7), PAH(17), PNMT(3), SLC18A3(12), TPH1(4)	9026307	127	90	119	54	42	19	12	44	10	0	0.746	1.000	1.000
454	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), JAK2(55), TYK2(5)	7151025	113	90	90	44	20	55	4	22	8	4	0.741	1.000	1.000
455	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), JAK2(55), TYK2(5)	7151025	113	90	90	44	20	55	4	22	8	4	0.741	1.000	1.000
456	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(7), CHUK(27), IFNG(3), IKBKB(9), IL2(5), IL4(5), JUN(2), MAP3K1(21), MAP3K5(16), MAP4K5(4), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), TNFRSF9(10), TRAF2(8)	13368999	164	89	147	40	44	41	16	44	19	0	0.0246	1.000	1.000
457	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PGK1(3), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TPI1(3)	12129487	126	89	116	46	35	20	15	40	16	0	0.548	1.000	1.000
458	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(19), CD2(7), CD33(3), CD5(9), CD7(6), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(18), TLR2(12), TLR4(18), TLR7(18), TLR9(16)	12701615	161	89	149	61	52	24	17	50	16	2	0.545	1.000	1.000
459	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2)	12938978	142	89	134	52	46	36	15	31	14	0	0.421	1.000	1.000
460	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(14), CLOCK(24), CRY1(17), CRY2(5), CSNK1D(15), CSNK1E(9), NPAS2(10), NR1D1(8), PER1(13), PER2(9), PER3(20)	11433966	144	89	116	31	45	29	10	33	25	2	0.00806	1.000	1.000
461	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(8), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTR(14)	11950916	149	89	139	46	57	20	19	27	25	1	0.207	1.000	1.000
462	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(22), AP2A1(5), AP2M1(6), BIN1(6), CALM2(1), CALM3(1), DNM1(16), EPN1(10), EPS15(14), NME1(1), PICALM(9), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYNJ1(28), SYNJ2(15), SYT1(14)	15355004	171	89	155	70	48	30	17	44	32	0	0.798	1.000	1.000
463	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(27), MAP3K14(6), MAPK14(8), MAPK8(17), NFKB1(11), RELA(10), TNFRSF13B(7), TNFRSF17(4), TNFSF13(2), TNFSF13B(4), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4)	9700198	133	89	120	38	44	29	10	25	25	0	0.211	1.000	1.000
464	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(6), CR1(20), CR2(22), FCGR2B(2), HLA-DRB1(7), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	9581861	136	88	134	46	31	19	22	33	29	2	0.549	1.000	1.000
465	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AGPS(6), CHPT1(4), ENPP2(27), ENPP6(11), PAFAH1B1(6), PAFAH1B3(2), PAFAH2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PPAP2A(2), PPAP2B(2), PPAP2C(3)	16146603	163	88	153	72	57	30	21	37	18	0	0.931	1.000	1.000
466	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(27), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(7), BIRC3(18), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), DIABLO(3), ENDOG(3)	9412726	127	88	98	32	20	19	17	31	39	1	0.352	1.000	1.000
467	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), SELE(13), SELL(5), SELP(15)	10693526	129	88	131	44	41	21	13	31	23	0	0.374	1.000	1.000
468	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4)	9027693	125	87	109	34	29	31	19	31	15	0	0.0634	1.000	1.000
469	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6)	11082560	143	86	125	51	34	32	15	37	24	1	0.663	1.000	1.000
470	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(15), BST1(3), C9orf95(2), CD38(5), ENPP1(17), ENPP3(12), NADK(8), NADSYN1(4), NMNAT1(3), NMNAT2(5), NMNAT3(5), NNMT(6), NNT(8), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT12(3), QPRT(2)	15172522	146	86	139	52	45	27	17	36	20	1	0.362	1.000	1.000
471	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12)	14305523	156	85	147	50	44	16	16	39	39	2	0.659	1.000	1.000
472	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(16), PGAP1(14), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGW(2), PIGX(4), PIGZ(6)	16362410	139	84	130	57	24	30	13	44	28	0	0.933	1.000	1.000
473	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(25), ABCC2(23), ABCG2(17), CES1(14), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10)	15469541	155	84	137	54	44	27	20	35	28	1	0.428	1.000	1.000
474	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), HAL(12)	13277194	136	84	127	51	41	26	17	29	23	0	0.731	1.000	1.000
475	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), PON1(12), PON2(7), PON3(14)	11598072	139	83	126	46	37	31	14	34	21	2	0.351	1.000	1.000
476	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(7), CAT(8), EPX(14), LPO(10), MPO(17), MTHFR(9), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36)	7671411	118	83	106	32	54	14	13	21	16	0	0.0871	1.000	1.000
477	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(7), ATP6V0C(1), CAT(8), EPX(14), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36)	7751352	117	83	105	34	55	14	13	18	17	0	0.106	1.000	1.000
478	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(7), FOS(5), GNAQ(11), JUN(2), MAPK14(8), MAPK8(17), PLCG1(19), PRKCA(8), PTK2B(13), SYT1(14)	9455777	120	82	108	51	26	31	9	36	18	0	0.944	1.000	1.000
479	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(16), JAK2(55), NFKB1(11), NFKBIA(1), RELA(10), SOD2(4)	8654048	116	82	100	47	24	44	13	17	15	3	0.727	1.000	1.000
480	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(13), ERBB4(65), NRG2(8), NRG3(18), PRKCA(8), PSEN1(4)	6360313	116	82	106	39	23	22	20	34	17	0	0.448	1.000	1.000
481	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(10), F2R(11), F3(2), F5(37), F7(7), FGA(23), FGB(6), FGG(7), PROC(3), PROS1(12), SERPINC1(8), TFPI(9)	11211396	140	82	131	54	37	29	20	38	16	0	0.723	1.000	1.000
482	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(6), ALDH18A1(8), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), GAMT(6), GATM(2), GLUD1(4), NAGS(6), OAT(4), ODC1(8), OTC(17), SMS(4)	11898702	137	81	127	38	39	29	19	33	17	0	0.0859	1.000	1.000
483	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(8), IFNGR2(5), JAK1(22), JAK2(55), STAT1(17)	5876778	110	80	91	40	22	47	4	21	11	5	0.632	1.000	1.000
484	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(6), ACADM(12), ACADS(4), ACADVL(6), ACSL1(9), ACSL3(12), ACSL4(10), CPT1A(13), CPT2(3), DCI(4), EHHADH(15), HADHA(12), SCP2(6), SLC25A20(2)	11733185	114	80	103	44	29	21	15	31	18	0	0.588	1.000	1.000
485	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2)	10562813	122	80	115	37	37	31	14	26	14	0	0.145	1.000	1.000
486	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), PANK1(7), PANK2(1), PANK3(7), PANK4(8), PPCS(4), UPB1(9)	9038743	128	80	119	35	22	25	24	39	17	1	0.0833	1.000	1.000
487	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), FDXR(5), SHMT1(7)	11185039	120	79	102	41	34	28	15	24	19	0	0.499	1.000	1.000
488	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), NCK1(1), NCKAP1(17), NTRK1(17), PIR(2), PSMA7(2), RAC1(2), WASF1(6), WASF2(5), WASF3(17), WASL(18)	10790657	130	78	123	44	36	16	19	36	23	0	0.488	1.000	1.000
489	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10716841	115	78	97	40	33	27	15	22	18	0	0.538	1.000	1.000
490	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(11), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK1(3), MAPK3(4), MYC(5), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RAF1(16), RELA(10), TNF(2)	10407445	117	78	106	48	39	21	19	22	16	0	0.658	1.000	1.000
491	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10716841	115	78	97	40	33	27	15	22	18	0	0.538	1.000	1.000
492	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(14), APAF1(27), BCL2(2), CASP3(4), CASP9(6), CYCS(1), DAXX(18), FAS(9), FASLG(3), HSPB2(3), IL1A(1), MAPKAPK2(5), MAPKAPK3(6), TNF(2)	7422406	101	78	81	37	18	30	13	17	23	0	0.755	1.000	1.000
493	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(36), CPT1A(13), LEP(1), LEPR(21), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7)	10370628	122	78	115	36	38	14	12	39	19	0	0.407	1.000	1.000
494	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(35), ABCB11(19), ABCB4(28), ABCC1(25), ABCC3(11), GSTP1(1)	9746347	119	78	123	37	23	20	18	32	24	2	0.409	1.000	1.000
495	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10716841	115	78	97	40	33	27	15	22	18	0	0.538	1.000	1.000
496	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(39), GNB1(3), GNGT1(1), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8)	6294507	90	77	73	33	39	21	2	16	12	0	0.475	1.000	1.000
497	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), CHST1(10), CHST2(13), CHST4(8), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	7278265	103	77	101	36	51	17	4	17	14	0	0.596	1.000	1.000
498	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(27), BAD(1), BAK1(2), BAX(16), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), CASP8AP2(30), CASP9(6), CES1(14)	7117379	113	77	92	31	21	10	19	23	38	2	0.650	1.000	1.000
499	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(27), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(4), CASP8(20), CASP9(6), CYCS(1), GZMB(5), JUN(2), PRF1(8)	6864885	91	76	75	32	17	19	9	20	26	0	0.742	1.000	1.000
500	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(25), C5(25), C6(27), C7(11), C8A(14), C9(12)	8778922	114	75	107	35	35	11	13	30	24	1	0.385	1.000	1.000
501	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(4), ALOX15(5), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(3), GGT1(11), LTA4H(2), PLA2G6(10), PTGDS(2), PTGES(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	9867332	102	75	94	37	34	11	12	22	23	0	0.596	1.000	1.000
502	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(1), IARS(10), IARS2(19), ILVBL(9), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3), VARS(7), VARS2(9)	11405023	107	75	105	41	42	17	14	19	15	0	0.723	1.000	1.000
503	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(2), MRPL13(8), MRPS7(4), RPL10A(3), RPL10L(4), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(4), RPL7(4), RPL8(3), RPL9(4), RPS10(2), RPS11(2), RPS13(2), RPS15A(1), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS5(2), RPS6(3), RPS7(1), RPS9(3), RPSA(1)	13694342	122	75	117	32	29	27	20	31	15	0	0.152	1.000	1.000
504	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2)	16195591	124	75	119	31	38	17	25	27	17	0	0.0476	1.000	1.000
505	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(24), CLTA(6), CLTB(3), COPA(14), GBF1(19), GPLD1(16), KDELR1(5), KDELR2(9), KDELR3(2)	11408612	110	74	106	39	31	21	14	22	22	0	0.652	1.000	1.000
506	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), PHPT1(2), RFK(1), TYR(12)	10560919	120	74	107	38	35	30	14	22	17	2	0.292	1.000	1.000
507	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(4), LCT(46), MPI(4), PGM1(10), PYGL(8), PYGM(12), TPI1(3), TREH(6)	9210110	106	73	98	34	34	22	15	28	7	0	0.170	1.000	1.000
508	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), IDS(5), LCT(46), NAGLU(6)	9533781	106	73	97	37	39	21	10	25	11	0	0.315	1.000	1.000
509	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELE(13), SELL(5)	8270708	100	73	98	38	27	17	9	26	21	0	0.696	1.000	1.000
510	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42)	11478171	122	71	108	39	37	15	21	31	18	0	0.356	1.000	1.000
511	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(21), ESR2(8), ITPKA(3), PDE1A(10), PDE1B(11), PLCB1(23), PLCB2(11), PRL(4), TRH(8), VIP(3)	7534369	102	71	94	39	28	19	15	24	16	0	0.677	1.000	1.000
512	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(5), CD3D(5), CD3E(2), IFNG(3), IL2(5), IL2RA(6), IL4(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), TOB1(8), TOB2(2)	7211875	118	71	102	39	37	29	13	23	16	0	0.297	1.000	1.000
513	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(9), CYB5R3(2), GCK(6), GFPT1(6), GNE(8), GNPDA1(2), GNPDA2(3), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), PGM3(7), RENBP(3), UAP1(6)	11659061	103	70	97	31	35	24	12	19	13	0	0.192	1.000	1.000
514	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(13), AMT(2), ATIC(14), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6)	12911227	107	70	101	51	33	17	16	22	17	2	0.944	1.000	1.000
515	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(5), CSF3(3), HLA-DRB1(7), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL11(6), IL12A(2), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), LTA(1), PDGFA(2), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2)	8684335	103	70	93	45	30	18	9	29	14	3	0.887	1.000	1.000
516	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(2), FH(10), IDH2(17), MDH1(8), OGDH(14), SDHA(14), SUCLA2(9)	6549626	81	69	71	29	22	15	8	22	14	0	0.581	1.000	1.000
517	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(6), JAK1(22), PTPRU(24), REG1A(8), STAT1(17), STAT2(12), TYK2(5)	8526878	101	69	92	27	39	21	8	18	14	1	0.133	1.000	1.000
518	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(14), EIF2AK4(23), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF5(6), GSK3B(17), PPP1CA(2)	7874754	85	68	72	21	14	31	6	15	19	0	0.136	1.000	1.000
519	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(9), CYSLTR2(18), GPR109B(5), GPR161(13), GPR171(11), GPR18(5), GPR34(11), GPR39(4), GPR45(14), GPR65(2), GPR68(5), GPR75(10)	6794550	107	68	93	44	30	21	7	29	19	1	0.841	1.000	1.000
520	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(6), B3GAT2(1), B3GAT3(2), B4GALT7(2), CHPF(10), CHST11(6), CHST12(6), CHST14(1), CHST3(7), CHSY1(14), DSE(10), UST(12), XYLT1(14), XYLT2(15)	8544270	106	68	88	51	41	16	12	18	18	1	0.953	1.000	1.000
521	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(2), BNIP1(5), GOSR1(5), GOSR2(6), SEC22B(3), SNAP23(2), SNAP25(2), SNAP29(4), STX11(7), STX12(6), STX16(7), STX17(2), STX18(3), STX19(4), STX2(6), STX3(4), STX4(3), STX5(11), STX6(2), STX7(4), STX8(7), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(4), VAMP4(4), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1), YKT6(1)	11075338	124	68	111	35	39	12	11	29	33	0	0.381	1.000	1.000
522	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(5), CD86(2), HLA-DRB1(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), IL2(5), IL2RA(6), IL4(5), IL4R(6)	8376012	99	68	89	32	23	19	14	24	16	3	0.324	1.000	1.000
523	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2)	9410902	88	67	89	34	19	21	9	26	13	0	0.734	1.000	1.000
524	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(4), GALNT10(8), GALNT2(15), GALNT3(15), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GCNT1(9), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4)	9088904	93	67	91	39	35	18	14	12	14	0	0.737	1.000	1.000
525	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(13), AMT(2), ATIC(14), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6)	12541796	102	67	94	49	30	18	15	21	16	2	0.941	1.000	1.000
526	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(6), FDFT1(4), FDPS(6), GGCX(11), GGPS1(5), HMGCR(7), IDI1(4), IDI2(3), LSS(5), MVD(3), MVK(16), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2), TM7SF2(2)	12916653	108	66	97	41	33	8	14	28	25	0	0.891	1.000	1.000
527	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(19), PSMD11(8), PSMD12(6), PSMD13(8), PSMD2(4), PSMD6(8)	11487542	97	66	88	37	25	24	11	25	12	0	0.728	1.000	1.000
528	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10)	11835122	102	66	88	30	27	14	13	18	30	0	0.450	1.000	1.000
529	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(5), CD3D(5), CD3E(2), CD4(4), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	7473398	102	66	96	41	25	16	15	23	23	0	0.782	1.000	1.000
530	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(19), CKM(7), FBL(6), GPT(7), LDHA(14), LDHB(8), LDHC(4), MAPK14(8), NCL(12)	6045227	85	65	74	33	21	21	12	24	7	0	0.641	1.000	1.000
531	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(5), CD3D(5), CD3E(2), CD8A(2), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	7012128	100	65	94	39	27	16	13	22	22	0	0.712	1.000	1.000
532	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(3), EPO(1), FLT3(36), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(7), IL9(2), KITLG(3), TGFB1(2), TGFB2(10), TGFB3(2)	5817287	85	64	75	40	21	21	7	23	12	1	0.940	1.000	1.000
533	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), NTAN1(10), SIRT1(8), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(5)	8175711	78	63	68	26	22	11	10	14	21	0	0.547	1.000	1.000
534	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(6), ICAM1(4), ITGAL(21), ITGAM(14), ITGB2(18), SELE(13), SELL(5)	6781644	81	63	87	27	30	12	8	16	15	0	0.363	1.000	1.000
535	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), NAT1(1), NAT2(3), XDH(19)	5673381	77	62	72	34	25	13	10	21	8	0	0.858	1.000	1.000
536	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PCYT1A(5), PCYT1B(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2)	9317773	82	62	85	36	19	18	9	23	13	0	0.915	1.000	1.000
537	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(6), IL10(2), IL10RA(4), IL10RB(7), IL1A(1), IL6(7), JAK1(22), STAT1(17), STAT3(10), STAT5A(10), TNF(2)	8331374	92	62	80	35	30	16	6	22	17	1	0.735	1.000	1.000
538	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CAMKK1(2), CAMKK2(9), CREB1(3), SYT1(14)	7873843	82	61	74	39	21	21	9	17	14	0	0.929	1.000	1.000
539	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), IMPA2(4), ISYNA1(6), PGM1(10), PGM3(7), TGDS(1)	7573819	80	61	75	33	33	12	8	18	9	0	0.607	1.000	1.000
540	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(8), IFNAR1(7), IFNAR2(4), IFNB1(6), JAK1(22), STAT1(17), STAT2(12), TYK2(5)	7400082	81	61	70	24	22	18	6	21	13	1	0.355	1.000	1.000
541	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(13), ADSS(8), DHFR(1), HPRT1(2), IMPDH1(4), MTHFD2(2), POLB(6), POLD1(20), POLG(9), PRPS2(6), RRM1(3), SRM(1)	8300600	75	61	74	31	28	7	12	14	14	0	0.783	1.000	1.000
542	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(3), DFFA(6), DFFB(2), ENDOG(3), GZMB(5), HMGB1(2), HMGB2(2), TOP2A(24), TOP2B(25)	6083306	76	60	71	18	10	15	8	22	21	0	0.439	1.000	1.000
543	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(14), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(3), CDK5R1(5), CSNK1A1(3), CSNK1D(15), GSK3B(17), MAPT(11), PPP2CA(3)	5698340	81	60	77	27	29	20	5	17	10	0	0.413	1.000	1.000
544	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(12), AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	5644014	73	59	67	28	32	12	6	14	9	0	0.589	1.000	1.000
545	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL15(1), IL16(18), IL18(3), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL8(6), IL9(2), LTA(1), TNF(2)	6679783	81	59	72	43	23	16	8	25	9	0	0.954	1.000	1.000
546	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(12), AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	5644014	73	59	67	28	32	12	6	14	9	0	0.589	1.000	1.000
547	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(12), ACO2(7), AFMID(3), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2)	9484795	83	59	76	26	25	10	13	24	11	0	0.242	1.000	1.000
548	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(15), CD38(5), ENPP1(17), ENPP3(12), NADSYN1(4), NMNAT1(3), NMNAT2(5), NNMT(6), NNT(8), NT5C(1), NT5E(7), NT5M(3), QPRT(2)	10368086	88	59	81	32	24	19	10	22	12	1	0.425	1.000	1.000
549	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(6), CSF1(5), FCGR3A(5), IL1B(5), IL6R(8), SELL(5), SPN(6), TGFB1(2), TGFB2(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(8), TNFSF8(6)	8798591	87	59	89	29	26	12	16	19	14	0	0.272	1.000	1.000
550	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(18), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(3), CDK2(5), CDK4(4), CDKN1B(6), CDKN2A(9), E2F2(7), E2F4(2), PRB1(5)	5854733	71	59	67	30	15	14	9	19	14	0	0.783	1.000	1.000
551	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(12), ACO2(7), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2)	9047504	80	58	73	24	24	10	13	22	11	0	0.201	1.000	1.000
552	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(5), FOSL1(1), FOSL2(5), IFNAR1(7), IFNAR2(4), IFNB1(6), MAPK8(17), NFKB1(11), RELA(10), TNFRSF11A(6), TNFSF11(8), TRAF6(4)	7427319	84	58	82	32	25	17	9	18	15	0	0.615	1.000	1.000
553	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(11), NEK1(20), WEE1(15)	4831657	73	58	64	26	11	19	5	19	18	1	0.833	1.000	1.000
554	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CSK(5), GRB2(11), PRKCA(8), PTPRA(6), SRC(3)	6378948	69	58	64	25	17	20	7	20	5	0	0.476	1.000	1.000
555	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(16), ENO1(3), GPI(6), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(12), TPI1(3)	5847539	67	57	59	29	22	13	5	20	7	0	0.833	1.000	1.000
556	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10)	6419614	77	56	76	26	24	10	8	23	12	0	0.514	1.000	1.000
557	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(6), B3GALT5(5), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST8SIA1(10)	6872877	84	56	81	28	30	10	9	23	12	0	0.434	1.000	1.000
558	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(7), UBE2A(5), UBE3A(25)	9226684	84	56	82	30	21	17	11	23	12	0	0.570	1.000	1.000
559	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(11), GNB1(3), GNGT1(1), HTR2C(15), PLCB1(23), TUB(14)	4961287	71	56	70	30	27	13	7	18	6	0	0.764	1.000	1.000
560	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	7	CD3D(5), CD3E(2), GZMB(5), ICAM1(4), ITGAL(21), ITGB2(18), PRF1(8)	4795831	63	55	58	28	27	9	3	9	15	0	0.805	1.000	1.000
561	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(5), GSR(5), GSS(9), IL8(6), NFKB1(11), NOX1(4), RELA(10), TNF(2), XDH(19)	6903227	71	55	66	23	17	22	7	11	14	0	0.457	1.000	1.000
562	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(8), ME1(14), PC(16), PDHA1(8), SLC25A1(1), SLC25A11(2)	6057386	63	55	57	21	23	15	7	11	7	0	0.344	1.000	1.000
563	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(9), CAMK1G(7), HDAC9(20), MEF2A(7), MEF2C(15), MEF2D(3), YWHAH(5)	4818752	66	55	74	32	21	9	3	22	10	1	0.956	1.000	1.000
564	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(5), MAX(5), MYC(5), SP1(7), SP3(13), WT1(32)	4179137	67	55	57	30	14	22	15	9	7	0	0.691	1.000	1.000
565	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(17), CHKA(6), PCYT1A(5), PDHA1(8), PDHA2(17), PEMT(2), SLC18A3(12)	4591510	72	54	70	43	30	9	10	18	5	0	0.968	1.000	1.000
566	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(6), FARSB(12), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4), YARS2(7)	6150246	78	53	71	25	19	8	12	27	12	0	0.474	1.000	1.000
567	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	5223575	64	53	59	19	26	14	3	12	9	0	0.439	1.000	1.000
568	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), PGM1(10), PGM3(7), TGDS(1)	6907599	70	53	65	29	28	11	7	17	7	0	0.652	1.000	1.000
569	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(28), GNA12(7), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6)	7123468	64	52	60	17	17	10	7	17	13	0	0.286	1.000	1.000
570	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(7), B3GALT1(3), B3GALT2(10), B3GALT5(5), B3GNT5(3), FUT1(11), FUT2(7), FUT3(6), ST3GAL3(12), ST3GAL4(4)	4700899	68	52	64	25	31	7	4	15	11	0	0.675	1.000	1.000
571	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(11), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10)	5746565	64	52	61	28	21	12	7	15	9	0	0.840	1.000	1.000
572	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14)	8476258	73	51	71	20	26	13	8	16	10	0	0.273	1.000	1.000
573	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), IDI1(4), LSS(5), MVD(3), MVK(16), NQO1(1), NQO2(3), PMVK(2), SC5DL(9), SQLE(2)	7185377	66	50	56	20	20	8	8	15	15	0	0.436	1.000	1.000
574	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), RFK(1), TYR(12)	6843528	74	49	65	20	20	19	9	15	9	2	0.146	1.000	1.000
575	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(2), CDK2(5), CDK4(4), CDKN1A(2), CDKN1B(6), CDKN2A(9), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(5)	4661823	59	49	55	21	10	14	8	11	16	0	0.632	1.000	1.000
576	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(6), FARS2(7), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4)	5934868	65	48	59	28	15	7	14	20	9	0	0.857	1.000	1.000
577	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(5), UBE2A(5), UBE2B(3), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(4), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(25)	7020427	74	48	72	22	20	13	6	17	18	0	0.275	1.000	1.000
578	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), HMGCS1(1), IDI1(4), LSS(5), MVD(3), MVK(16), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2)	8736823	71	47	62	23	21	7	8	18	17	0	0.639	1.000	1.000
579	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), ECHS1(4), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), MECR(4), PPT1(1), PPT2(5)	5881095	54	47	53	18	14	9	6	13	12	0	0.456	1.000	1.000
580	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(10), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3)	7048795	62	46	61	27	20	11	9	14	8	0	0.859	1.000	1.000
581	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(15), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(6), APOBEC3F(2), APOBEC3G(8), APOBEC4(9)	5191508	57	44	56	17	22	5	10	10	10	0	0.312	1.000	1.000
582	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14), XYLT2(15)	3963660	51	43	39	24	19	7	2	8	14	1	0.974	1.000	1.000
583	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14), XYLT2(15)	3963660	51	43	39	24	19	7	2	8	14	1	0.974	1.000	1.000
584	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	11	CD2(7), CD34(7), CD3D(5), CD3E(2), CD4(4), CD8A(2), CSF3(3), IL3(6), IL6(7), IL8(6), KITLG(3)	3875790	52	43	44	23	12	14	5	13	8	0	0.748	1.000	1.000
585	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3)	4996405	57	43	55	15	17	6	5	10	19	0	0.269	1.000	1.000
586	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(39), GLS(2), GLUD1(4), GOT1(7)	5422364	59	43	52	16	14	14	10	14	7	0	0.214	1.000	1.000
587	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(3), FOS(5), JUN(2), KEAP1(5), MAPK1(3), MAPK14(8), MAPK8(17), NFE2L2(7), PRKCA(8)	5625930	58	42	57	24	13	12	5	20	8	0	0.803	1.000	1.000
588	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(11), MBTPS1(14), MBTPS2(2), SCAP(9), SREBF1(8), SREBF2(10)	7338535	55	42	54	28	16	13	8	10	8	0	0.839	1.000	1.000
589	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	BPNT1(9), CHST11(6), CHST12(6), PAPSS1(5), PAPSS2(7), SULT1A1(4), SULT1A2(4), SULT1E1(6), SULT2A1(6), SULT2B1(4), SUOX(5)	6526346	62	41	58	21	20	9	5	20	8	0	0.560	1.000	1.000
590	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(3), FOS(5), FYN(17), JUN(2), MAPK14(8), THBS1(14)	5017622	53	41	48	20	14	9	6	11	13	0	0.587	1.000	1.000
591	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(12), AOC3(10), CES1(14), ESD(5)	4004121	45	39	44	23	15	6	8	11	5	0	0.869	1.000	1.000
592	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(7), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), ST3GAL3(12)	2690635	48	39	45	19	26	5	3	9	5	0	0.593	1.000	1.000
593	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(7), SEC61A2(4), SRP19(1), SRP54(4), SRP68(13), SRP72(9), SRPR(13)	5300023	51	39	42	13	11	7	7	13	13	0	0.471	1.000	1.000
594	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(19), PRKCA(8), PTK2B(13)	4596991	48	39	44	26	15	12	6	9	6	0	0.967	1.000	1.000
595	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(8), F13B(12), HSD17B1(2), HSD17B2(7), HSD17B3(6), HSD17B4(9), HSD3B1(6), HSD3B2(4)	5650953	54	39	52	23	18	10	7	13	6	0	0.646	1.000	1.000
596	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(9), GAD1(17), HDC(14), PNMT(3), TPH1(4)	3543730	47	38	45	19	14	7	3	18	5	0	0.718	1.000	1.000
597	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(11), CYP2E1(11), NR1I3(5), PTGS1(10), PTGS2(10)	3714878	47	37	47	19	22	4	8	9	4	0	0.722	1.000	1.000
598	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(10), CYP11A1(7), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	4653077	45	37	43	26	18	7	7	7	6	0	0.916	1.000	1.000
599	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(11), NR1H3(16), NR1H4(9), RXRA(8)	3464000	46	36	39	21	14	9	6	6	11	0	0.904	1.000	1.000
600	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(12), ALAS2(12), CPOX(4), FECH(4), HMBS(5), PPOX(5), UROD(3), UROS(5)	5397606	51	36	47	13	21	8	5	11	6	0	0.344	1.000	1.000
601	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(6), ACADM(12), ACADS(4), ACAT1(7), ECHS1(4), HADHA(12)	3709116	45	35	43	19	12	6	6	8	13	0	0.746	1.000	1.000
602	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(7), GOT2(2), TAT(16), TYR(12)	3360193	42	35	34	22	11	6	11	11	3	0	0.911	1.000	1.000
603	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMB8(9), PSMB9(4)	5875820	44	35	43	19	9	5	5	17	8	0	0.855	1.000	1.000
604	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(7), ACAT2(9), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(1), HMGCS2(6), OXCT1(3), OXCT2(3)	5121005	36	33	34	14	13	6	3	7	7	0	0.701	1.000	1.000
605	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(7), CSF1(5), IL6(7), LDLR(11), LPL(12)	3651205	42	33	39	19	14	12	3	7	6	0	0.692	1.000	1.000
606	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(12), NR3C1(11), PPARG(4), RETN(2), RXRA(8), TNF(2)	3753014	41	33	37	25	10	8	8	8	7	0	0.970	1.000	1.000
607	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), DHFR(1), FPGS(4), GGH(2), SPR(7)	3636482	37	32	37	15	12	7	5	9	4	0	0.609	1.000	1.000
608	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(10), PRKCA(8), TGM2(17)	3400591	41	31	40	21	17	6	3	12	3	0	0.853	1.000	1.000
609	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(5), IL1B(5), MST1(5), MST1R(14), TNF(2)	3518329	31	28	28	11	11	5	4	8	3	0	0.496	1.000	1.000
610	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(2), CCR3(11), HLA-DRB1(7), IL3(6)	1585747	26	25	21	12	5	9	0	7	3	2	0.937	1.000	1.000
611	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(8), ARG1(2), GLS(2), GLUD1(4), OAT(4), PRODH(5)	3682869	25	23	24	12	11	7	2	1	4	0	0.760	1.000	1.000
612	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(12), SNAP25(2), STX1A(4), VAMP2(1)	2245011	23	23	20	11	7	6	3	6	1	0	0.907	1.000	1.000
613	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(7), GOT2(2), TAT(16)	1889276	25	21	19	13	7	1	9	5	3	0	0.867	1.000	1.000
614	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(7), ACAT2(9), HMGCL(1), OXCT1(3)	2416096	20	18	18	10	3	5	3	5	4	0	0.890	1.000	1.000
615	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(6), IFNG(3), IL12A(2), IL12B(1), IL18(3), IL2(5)	2128698	20	15	19	16	1	4	6	7	2	0	0.995	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	365947	1	1	1	2	1	0	0	0	0	0	0.955	1.000	1.000
