rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(11)	513817	11	11	11	1	9	0	1	1	0	0	0.107	0.152	1.000
2	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(9), LIPT1(13)	1090040	22	19	17	1	0	3	2	6	11	0	0.132	0.217	1.000
3	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(3)	1063963	9	9	9	1	0	1	1	7	0	0	0.306	0.788	1.000
4	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(5), CD4(4), HLA-DRB1(7)	1196858	16	14	15	7	2	0	2	5	5	2	0.941	0.871	1.000
5	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPX1(5), PRKCE(6)	5195954	119	86	107	26	31	17	14	40	17	0	0.00673	0.898	1.000
6	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(12), ALDH1A2(17), BCMO1(5), RDH5(2)	2727712	36	33	35	8	10	8	5	9	4	0	0.117	0.956	1.000
7	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), GSTZ1(5), HGD(6)	1586183	15	13	14	4	1	3	5	4	2	0	0.278	0.962	1.000
8	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	2	CD3D(5), CD3E(2)	572147	7	7	4	3	0	5	1	0	1	0	0.673	0.970	1.000
9	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	4	ALDH6A1(6), ALDOA(2), ALDOC(3), TPI1(3)	2014016	14	13	14	1	4	1	1	8	0	0	0.0914	0.970	1.000
10	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	7	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4)	4842817	81	59	74	12	27	13	11	20	10	0	0.00106	0.973	1.000
11	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	7	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4)	4842817	81	59	74	12	27	13	11	20	10	0	0.00106	0.973	1.000
12	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(4), CASP8(20), CFL1(2), CFLAR(3), PDE6D(2)	2623925	33	30	31	5	5	3	4	8	13	0	0.130	0.980	1.000
13	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), IL8(6), SLPI(2)	1095078	17	16	16	7	2	3	2	4	6	0	0.766	0.985	1.000
14	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(14), SPCS1(3), SPCS3(2)	2144483	24	21	22	6	9	3	2	7	3	0	0.201	0.997	1.000
15	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(7), B3GNT1(5), FUT1(11), FUT2(7), FUT9(10), GCNT2(26), ST8SIA1(10)	3829261	76	59	70	20	24	8	9	23	11	1	0.0900	0.999	1.000
16	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(12), CYP2C9(11)	1451222	23	21	22	5	3	8	2	9	1	0	0.292	0.999	1.000
17	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(11), CD28(5), CD3D(5), CD3E(2), CD4(4)	2096860	27	25	23	8	4	5	5	8	5	0	0.447	1.000	1.000
18	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	11	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), SDS(3)	7739440	115	80	104	21	35	18	18	26	18	0	0.00107	1.000	1.000
19	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(3), FOSB(6), GRIA2(29), PPP1R1B(1)	2306760	39	34	38	13	15	6	4	11	3	0	0.311	1.000	1.000
20	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(12), AGTR1(14), AGTR2(17), BDKRB2(6), KNG1(9), NOS3(23), REN(10)	6037396	105	68	90	20	30	9	11	29	26	0	0.0125	1.000	1.000
21	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(4), GALT(3), TGDS(1), UGDH(9), UGP2(12), UXS1(9)	3429686	38	33	39	7	8	2	6	11	11	0	0.281	1.000	1.000
22	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	8	ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), MIOX(3), UGDH(9)	5027341	72	53	64	14	20	11	10	15	16	0	0.0476	1.000	1.000
23	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	5	BAAT(3), CDO1(3), CSAD(6), GAD1(17), GAD2(15)	3319509	44	39	36	11	18	6	6	11	3	0	0.140	1.000	1.000
24	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(4), GALT(3), TGDS(1), UGDH(9), UXS1(9)	2672136	26	25	27	6	6	2	4	6	8	0	0.490	1.000	1.000
25	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(8), ERBB3(32), NRG1(33), UBE2D1(1)	5419920	74	60	62	15	22	18	9	13	12	0	0.0538	1.000	1.000
26	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BIRC3(18), CASP8(20), FADD(1), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	4678118	61	49	51	16	12	15	5	11	18	0	0.160	1.000	1.000
27	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(7), ACAT2(9), ACYP1(2), ECHS1(4), EHHADH(15), GCDH(8), HADHA(12), SDHB(3), SDS(3)	5405606	63	50	57	14	15	10	11	14	13	0	0.0664	1.000	1.000
28	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(9), SUCLA2(9)	1413285	18	17	18	7	8	2	3	3	2	0	0.594	1.000	1.000
29	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(4), RANBP1(6), RANBP2(32), RANGAP1(4)	5440776	46	35	43	8	8	7	6	17	8	0	0.0692	1.000	1.000
30	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(6), GLUD1(4), GLUD2(22)	3043522	34	32	34	9	12	6	2	12	2	0	0.368	1.000	1.000
31	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(14), RAB11A(4), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(4), RAB6A(4), RAB9A(3)	2927576	42	33	40	12	13	6	9	6	8	0	0.224	1.000	1.000
32	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(9)	1207021	14	12	14	6	4	1	3	5	1	0	0.726	1.000	1.000
33	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(9), PAPSS1(5), PAPSS2(7), SULT1A2(4), SULT1E1(6), SULT2A1(6), SUOX(5)	4786107	42	28	38	7	11	5	4	15	7	0	0.103	1.000	1.000
34	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(4), CTH(6), MUT(8)	3247633	27	22	27	6	10	1	7	4	5	0	0.160	1.000	1.000
35	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(6), ST6GALNAC4(4), ST8SIA1(10)	3762847	34	31	32	9	11	7	4	6	6	0	0.205	1.000	1.000
36	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	3264996	27	24	24	7	11	4	1	8	3	0	0.324	1.000	1.000
37	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(2), CSF1(5), CSF3(3), EPO(1), IL11(6), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), IL9(2)	4283263	56	43	52	16	19	11	6	15	4	1	0.180	1.000	1.000
38	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	GATA3(17), IL13(2), IL4(5), MAF(9), MAP2K3(11), MAPK14(8), NFATC2(12), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	6718345	99	76	94	29	41	21	6	17	14	0	0.0862	1.000	1.000
39	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	5	IFNG(3), IFNGR1(8), IFNGR2(5), JAK1(22), STAT1(17)	4206167	55	42	49	15	16	12	0	15	10	2	0.407	1.000	1.000
40	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(15), PDXK(1), PDXP(1), PNPO(2), PSAT1(7)	3361327	26	22	25	7	6	7	3	6	4	0	0.341	1.000	1.000
41	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	4	ATP6V0C(1), GBA3(3), SHMT1(7), SHMT2(5)	1972343	16	16	19	8	6	1	2	3	4	0	0.876	1.000	1.000
42	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(7), MMP2(18), MMP9(19), RECK(14), TIMP1(2), TIMP2(3), TIMP3(11), TIMP4(4)	5166574	82	60	78	22	41	13	6	14	8	0	0.0665	1.000	1.000
43	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(2), CCR3(11), CD4(4), HLA-DRB1(7), IL1B(5), IL4(5), IL5RA(11), IL6(7)	3331389	52	33	46	17	17	7	5	16	5	2	0.488	1.000	1.000
44	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	BGN(8), DCN(9), FMOD(8), KERA(9)	1998166	34	30	33	11	9	6	1	15	3	0	0.648	1.000	1.000
45	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(13), DLL1(10), FURIN(17), PSEN1(4)	3217820	44	34	44	13	16	6	5	8	9	0	0.223	1.000	1.000
46	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(6), IDI1(4), SQLE(2)	2105761	16	16	17	5	1	2	4	5	4	0	0.601	1.000	1.000
47	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(7), ACAA2(4), ACAT1(7), ACAT2(9), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), SDS(3)	5892793	71	60	65	20	14	14	13	16	14	0	0.162	1.000	1.000
48	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(4), EHHADH(15), HADHA(12), SDS(3)	3381529	34	31	30	11	8	5	7	6	8	0	0.423	1.000	1.000
49	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(2), COQ6(4), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1)	2825492	18	18	21	6	6	1	7	2	2	0	0.476	1.000	1.000
50	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(6), GGPS1(5), IDI1(4), IDI2(3), SQLE(2)	2887472	24	23	24	7	4	2	4	7	7	0	0.562	1.000	1.000
51	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	7	ADORA1(18), ADORA2A(7), ADORA2B(5), LTB4R(2), P2RY1(8), P2RY2(8), P2RY6(6)	2664314	54	39	50	18	24	10	8	9	3	0	0.113	1.000	1.000
52	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	7	ADAM17(13), AXIN1(10), BTRC(11), DLL1(10), FZD1(9), GSK3B(17), PSEN1(4)	5342044	74	53	71	22	22	14	11	13	13	1	0.128	1.000	1.000
53	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(27), CREM(10), FHL5(11), FSHB(6), FSHR(19), XPO1(9)	5181748	82	61	72	25	27	21	8	19	7	0	0.248	1.000	1.000
54	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	2	BMP1(17), BMPR1B(15)	2024102	32	27	31	10	11	5	2	7	7	0	0.647	1.000	1.000
55	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(7), ACOX1(11), ACOX3(10), ELOVL2(9), ELOVL5(3), ELOVL6(4), FADS2(12), HADHA(12), HSD17B12(3), SCD(4)	7469545	75	60	71	17	25	8	12	18	12	0	0.0305	1.000	1.000
56	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(5), CD4(4), CD80(6), HLA-DRB1(7), IL10(2), IL2(5), IL4(5)	2352651	34	23	32	11	8	4	5	10	5	2	0.588	1.000	1.000
57	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	10	ADCY1(27), ADRB2(3), PLCE1(34), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAP2B(3)	8506327	102	72	98	27	34	23	6	27	12	0	0.0485	1.000	1.000
58	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(12), ACO1(12), ACO2(7), ACSS1(7), ACSS2(10), FH(10), IDH2(17), MDH1(8), MDH2(3), SUCLA2(9)	8714026	95	76	86	24	23	19	12	27	14	0	0.0757	1.000	1.000
59	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(15), PARK2(14), SNCA(2), SNCAIP(8), UBE2E2(4), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5)	4435755	54	42	53	17	16	2	9	20	7	0	0.409	1.000	1.000
60	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(14), KARS(8)	3412261	27	24	25	8	4	4	6	8	5	0	0.534	1.000	1.000
61	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	C9orf47(2), CNR1(13), CNR2(1), DNMT1(28), MTNR1A(3), MTNR1B(15), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2)	6920622	88	64	80	23	41	10	7	18	12	0	0.0149	1.000	1.000
62	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(12), ACO2(7), FH(10), IDH2(17), MDH1(8), MDH2(3), SDHB(3), SUCLA2(9)	5673949	69	63	61	20	13	14	9	21	12	0	0.293	1.000	1.000
63	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(4), GBA3(3), LPO(10), MPO(17), PRDX6(5), TPO(36)	5518266	89	69	82	22	43	12	8	14	12	0	0.0534	1.000	1.000
64	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(6), CDK7(3), MNAT1(4), SHH(3), XPO1(9)	6040819	62	50	60	15	16	12	8	21	5	0	0.138	1.000	1.000
65	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	3	ACACA(36), ACACB(40), MCAT(3)	7490906	79	54	76	17	30	11	13	17	8	0	0.0254	1.000	1.000
66	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9)	3892945	46	41	42	17	5	15	6	16	4	0	0.524	1.000	1.000
67	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	CISH(2), IFNG(3), IFNGR1(8), JAK1(22), PTPRU(24), REG1A(8), STAT1(17)	6290372	84	60	76	22	35	15	4	15	13	2	0.181	1.000	1.000
68	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(27), DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10)	6120079	64	49	58	14	21	18	6	9	10	0	0.0624	1.000	1.000
69	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(27), BAD(1), BAK1(2), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), CASP8AP2(30), CASP9(6), CES1(14)	6785459	97	68	87	28	21	10	18	21	26	1	0.536	1.000	1.000
70	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(3), CDK5R1(5), DPM2(1), EGR1(14), HRAS(4), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NGFR(5)	4106702	58	46	54	21	23	5	6	14	10	0	0.405	1.000	1.000
71	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(1), GPD2(11), NDUFA1(2), SDHA(14), SDHB(3), SDHD(4), UQCRC1(4)	4494132	46	35	46	12	18	4	8	13	3	0	0.233	1.000	1.000
72	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(11), ACOX3(10), FADS2(12), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10)	7146239	74	54	70	18	30	11	8	15	10	0	0.0458	1.000	1.000
73	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), GBA3(3), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TPO(36), TYR(12)	6336993	104	78	95	28	48	17	10	17	12	0	0.0653	1.000	1.000
74	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	11	AKT1(11), BAD(1), HRAS(4), IGF1R(22), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), SHC1(14), SOS1(16), YWHAH(5)	8694681	113	87	98	29	32	19	17	21	23	1	0.0891	1.000	1.000
75	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), KARS(8)	5021396	52	44	47	15	8	9	10	16	9	0	0.422	1.000	1.000
76	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), PGD(7)	11029534	147	91	135	31	34	24	23	49	17	0	0.00318	1.000	1.000
77	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(12), ALAS2(12), CPO(10), FECH(4), GATA1(19), HBB(3), HMBS(5), UROD(3), UROS(5)	5728569	74	52	68	18	23	17	7	17	10	0	0.113	1.000	1.000
78	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), RAC1(2), WASF1(6), WASL(18)	5691919	72	48	69	20	21	9	11	19	12	0	0.202	1.000	1.000
79	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(12), PON2(7), PON3(14), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	5765037	77	58	67	23	20	19	8	19	11	0	0.262	1.000	1.000
80	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(2), CTSD(6), ESR1(21), GREB1(29), HSPB2(3), MTA1(6), MTA3(4), PDZK1(2), TUBA8(5)	6286975	78	55	77	25	29	8	10	16	15	0	0.293	1.000	1.000
81	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(10), GNAQ(11), ITPKA(3), ITPKB(15)	3673735	44	37	41	15	15	9	3	11	6	0	0.476	1.000	1.000
82	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(19), EGF(8), HGS(10), RAB5A(4), TF(21), TFRC(7)	7052242	69	52	61	20	14	16	8	15	15	1	0.210	1.000	1.000
83	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(10), FOS(5), JUN(2), MAPK3(4), OPRK1(14), POLR2A(14), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	8802767	87	71	83	22	34	15	5	15	18	0	0.0858	1.000	1.000
84	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(8), ANKRD1(9), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(13), IL18(3), IL1A(1), IL1R1(7), MYOG(6), NR4A3(9), WDR1(7)	7302242	70	45	69	16	20	14	9	18	9	0	0.0669	1.000	1.000
85	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	8	CD3D(5), CD3E(2), CD4(4), FYN(17), HLA-DRB1(7), LCK(9), PTPRC(36), ZAP70(12)	5588107	92	72	79	28	21	19	14	16	20	2	0.250	1.000	1.000
86	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	177	ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), BAD(1), BCAR1(6), BCL2(2), BIRC2(7), BIRC3(18), CAPN2(10), CAV1(1), CAV2(4), CAV3(4), CCND1(2), CCND2(3), CCND3(2), CDC42(3), CHAD(10), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), CRKL(5), DIAPH1(7), DOCK1(24), EGF(8), ELK1(4), FARP2(13), FIGF(6), FLNA(31), FLNB(40), FLNC(39), FLT1(43), FN1(58), FYN(17), GRLF1(19), GSK3B(17), HGF(17), HRAS(4), IBSP(6), IGF1(6), IGF1R(22), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), JUN(2), KDR(42), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), MAP2K1(12), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PDPK1(4), PGF(4), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PRKCA(8), PRKCG(24), PTEN(333), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1A(2), RAP1B(2), RAPGEF1(19), RELN(95), ROCK1(35), ROCK2(20), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SPP1(4), SRC(3), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TLN1(23), TLN2(17), TNC(41), TNN(33), TNR(48), VASP(4), VAV1(24), VAV3(30), VCL(10), VEGFA(5), VEGFC(15), VTN(13), VWF(36), ZYX(5)	222687044	3229	422	2927	1307	910	691	409	744	455	20	0.961	1.000	1.000
87	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	157	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY7(13), ADCY8(34), ADCY9(22), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), ATP2A1(24), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), ATP2B4(26), AVPR1A(15), AVPR1B(5), BDKRB1(4), BDKRB2(6), BST1(3), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CCKAR(9), CCKBR(16), CD38(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM5(6), CHRNA7(1), CYSLTR1(9), DRD1(9), EDNRA(9), EDNRB(19), ERBB3(32), ERBB4(65), F2R(11), GNA11(8), GNA14(13), GNA15(6), GNAL(5), GNAQ(11), GRIN1(5), GRIN2A(55), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), GRPR(4), HRH1(4), HRH2(16), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MYLK(33), MYLK2(10), NOS1(31), NOS3(23), NTSR1(5), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), PDE1A(10), PDE1B(11), PDE1C(19), PDGFRA(64), PDGFRB(21), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PLN(1), PPID(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTAFR(1), PTGFR(8), PTK2B(13), RYR1(70), RYR2(138), RYR3(84), SLC25A4(4), SLC25A5(10), SLC8A1(24), SLC8A2(16), SLC8A3(17), SPHK1(3), SPHK2(5), TACR1(9), TACR2(4), TACR3(18), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(17), VDAC1(6), VDAC2(4), VDAC3(2)	164386910	2473	411	2373	915	885	428	272	537	340	11	0.351	1.000	1.000
88	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	213	ADCYAP1R1(5), ADORA1(18), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA2A(5), ADRA2B(7), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), C5AR1(8), CALCR(12), CALCRL(9), CCKAR(9), CCKBR(16), CGA(3), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CNR1(13), CNR2(1), CRHR1(6), CRHR2(6), CTSG(5), CYSLTR1(9), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2(10), F2R(11), F2RL2(8), FPR1(8), FSHB(6), FSHR(19), GABBR1(20), GABBR2(23), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GABRB1(11), GABRB2(10), GABRB3(19), GABRD(6), GABRE(12), GABRG1(21), GABRG2(20), GABRG3(12), GABRP(13), GABRQ(19), GABRR1(5), GABRR2(8), GALR1(5), GH1(5), GH2(6), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(11), GLP2R(10), GLRA1(10), GLRA2(9), GLRA3(13), GLRB(14), GNRHR(9), GPR156(17), GPR35(3), GPR50(9), GPR63(7), GPR83(7), GRIA1(38), GRIA2(29), GRIA3(15), GRIA4(46), GRID1(30), GRID2(28), GRIK1(13), GRIK2(49), GRIK3(33), GRIK4(21), GRIK5(15), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRIN3A(19), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM6(27), GRM7(36), GRM8(29), GRPR(4), GZMA(11), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HRH4(6), HTR1A(17), HTR1B(13), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LEP(1), LEPR(21), LHB(3), LTB4R(2), MAS1(3), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), MCHR1(8), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPBWR1(7), NPBWR2(1), NPFFR1(1), NPFFR2(14), NPY1R(6), NPY2R(12), NPY5R(7), NR3C1(11), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), P2RY1(8), P2RY10(15), P2RY14(11), P2RY2(8), P2RY4(8), P2RY6(6), PARD3(13), PPYR1(8), PRL(4), PRLHR(5), PRLR(10), PRSS1(7), PRSS3(6), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTH2R(16), RXFP1(7), RXFP2(21), SCTR(6), SSTR1(12), SSTR2(6), SSTR4(14), TAAR1(7), TAAR2(7), TAAR5(10), TAAR6(7), TAAR8(6), TAAR9(6), TACR1(9), TACR2(4), TACR3(18), THRA(6), THRB(14), TRHR(9), TRPV1(11), TSHB(2), VIPR1(7), VIPR2(11)	136389279	2374	410	2172	884	845	394	266	580	285	4	0.129	1.000	1.000
89	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	132	ACTB(4), ACTG1(6), CHAD(10), COL11A2(19), COL17A1(16), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), DES(6), DSC1(14), DSC2(17), DSC3(13), DSG1(23), DSG2(12), DSG3(17), DSG4(29), FN1(58), GJA1(9), GJA10(17), GJA3(5), GJA4(3), GJA5(7), GJA8(22), GJA9(6), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GJB7(4), GJC1(10), GJC3(4), GJD2(5), GJD4(4), IBSP(6), INA(9), ITGA6(16), ITGB4(18), KRT1(19), KRT10(7), KRT12(7), KRT13(11), KRT14(10), KRT15(9), KRT16(5), KRT17(11), KRT18(3), KRT19(4), KRT2(15), KRT20(3), KRT23(9), KRT24(5), KRT25(12), KRT27(3), KRT28(5), KRT3(13), KRT31(12), KRT32(7), KRT33A(8), KRT33B(6), KRT34(11), KRT35(7), KRT36(5), KRT37(11), KRT38(3), KRT39(9), KRT40(2), KRT5(8), KRT6A(8), KRT6B(6), KRT6C(7), KRT7(6), KRT71(9), KRT72(14), KRT73(14), KRT74(9), KRT75(14), KRT76(9), KRT77(6), KRT78(6), KRT79(8), KRT8(4), KRT81(3), KRT82(7), KRT83(4), KRT84(12), KRT85(15), KRT86(4), KRT9(13), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), LMNA(1), LMNB1(11), LMNB2(3), NES(30), PRPH(3), RELN(95), SPP1(4), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VIM(9), VTN(13), VWF(36)	156162691	2085	385	1958	843	748	308	282	470	276	1	0.892	1.000	1.000
90	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	228	AKT1(11), AKT2(8), AKT3(8), ARRB1(4), ARRB2(1), ATF2(7), ATF4(4), BDNF(5), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CACNA2D1(31), CACNA2D2(9), CACNA2D3(24), CACNA2D4(13), CACNB1(6), CACNB2(11), CACNB3(3), CACNB4(4), CACNG1(5), CACNG2(6), CACNG3(12), CACNG4(4), CACNG5(9), CACNG6(4), CACNG7(9), CACNG8(2), CASP3(4), CD14(6), CDC25B(11), CDC42(3), CHUK(27), CRKL(5), DAXX(18), DDIT3(5), DUSP1(7), DUSP10(6), DUSP16(11), DUSP3(4), DUSP4(6), DUSP5(2), DUSP6(7), DUSP7(8), DUSP9(9), ECSIT(7), EGF(8), ELK1(4), FAS(9), FASLG(3), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR3(26), FGFR4(12), FLNA(31), FLNB(40), FLNC(39), FOS(5), GADD45G(1), GNA12(7), HRAS(4), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAPT(11), MAX(5), MEF2C(15), MKNK1(4), MKNK2(7), MOS(10), MRAS(4), MYC(5), NFATC2(12), NFATC4(12), NFKB1(11), NFKB2(6), NLK(12), NR4A1(3), NTF3(3), NTRK1(17), NTRK2(25), PAK1(11), PAK2(15), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PPM1A(9), PPM1B(6), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PPP5C(9), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTPN5(8), PTPN7(4), PTPRR(16), RAC1(2), RAC2(1), RAC3(2), RAP1A(2), RAP1B(2), RAPGEF2(35), RASA1(24), RASA2(17), RASGRF1(25), RASGRF2(26), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KA6(18), RRAS(2), RRAS2(7), SOS1(16), SOS2(17), SRF(4), STK3(8), STK4(9), STMN1(2), TAOK1(17), TAOK2(14), TAOK3(20), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF1A(4), TRAF2(8), TRAF6(4), ZAK(12)	171931370	2353	375	2201	785	749	449	273	511	363	8	0.00789	1.000	1.000
91	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	187	ABI2(5), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), ARAF(10), ARHGEF1(15), ARHGEF12(12), ARHGEF4(9), ARHGEF6(19), ARHGEF7(23), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(4), BAIAP2(7), BCAR1(6), BDKRB1(4), BDKRB2(6), CD14(6), CDC42(3), CFL1(2), CFL2(2), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CRKL(5), CSK(5), CYFIP1(16), CYFIP2(10), DIAPH1(7), DIAPH2(28), DIAPH3(19), DOCK1(24), EGF(8), EZR(3), F2(10), F2R(11), FGD1(21), FGD3(16), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR3(26), FGFR4(12), FN1(58), GIT1(4), GNA12(7), GNA13(3), GRLF1(19), GSN(4), HRAS(4), IQGAP1(31), IQGAP2(32), IQGAP3(24), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LIMK1(8), LIMK2(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MOS(10), MRAS(4), MSN(9), MYH10(17), MYH14(25), MYH9(43), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), NCKAP1(17), NCKAP1L(25), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PFN2(4), PFN4(6), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RDX(16), ROCK1(35), ROCK2(20), RRAS(2), RRAS2(7), SCIN(10), SLC9A1(12), SOS1(16), SOS2(17), SSH1(15), SSH2(16), SSH3(4), TIAM1(42), TIAM2(26), TMSL3(2), VAV1(24), VAV3(30), VCL(10), WAS(4), WASF1(6), WASF2(5), WASL(18)	170721394	2193	368	2044	789	635	403	267	528	348	12	0.526	1.000	1.000
92	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	82	CD36(3), CD44(6), CD47(8), CHAD(10), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), DAG1(10), FN1(58), FNDC1(44), FNDC3A(15), FNDC4(6), FNDC5(2), GP5(9), GP6(13), GP9(1), HMMR(17), HSPG2(27), IBSP(6), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), RELN(95), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SPP1(4), SV2A(24), SV2B(11), SV2C(13), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VTN(13), VWF(36)	140472741	1818	366	1718	753	619	271	237	429	258	4	0.945	1.000	1.000
93	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(21), ATP1B1(4), ATP1B2(4), ATP1B3(4), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1S(34), CACNB1(6), CACNB3(3), CALM2(1), CALM3(1), CALR(2), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CASQ1(5), CASQ2(11), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), GJA1(9), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), ITPR1(43), ITPR2(49), ITPR3(44), KCNB1(22), KCNJ3(11), KCNJ5(11), MIB1(13), MYCBP(1), NME7(9), PEA15(1), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLN(1), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SLC8A3(17), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1)	121877764	1725	364	1687	639	637	270	191	368	250	9	0.312	1.000	1.000
94	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	124	ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), AMOTL1(15), ASH1L(64), CASK(11), CDC42(3), CDK4(4), CGN(18), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTTN(5), EPB41(11), EPB41L1(14), EPB41L2(12), EPB41L3(35), EXOC3(3), EXOC4(22), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), HCLS1(16), HRAS(4), IGSF5(16), INADL(18), JAM2(2), JAM3(9), LLGL1(7), LLGL2(8), MAGI1(31), MAGI2(32), MAGI3(10), MLLT4(21), MPDZ(26), MPP5(7), MRAS(4), MYH1(47), MYH10(17), MYH11(49), MYH13(28), MYH14(25), MYH15(37), MYH2(42), MYH3(46), MYH4(30), MYH6(34), MYH7(28), MYH7B(31), MYH8(47), MYH9(43), MYL2(2), MYL7(1), MYL9(3), OCLN(2), PARD3(13), PARD6A(2), PARD6B(2), PARD6G(7), PPM1J(3), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP2R3A(16), PPP2R4(4), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PTEN(333), RAB13(1), RAB3B(3), RRAS(2), RRAS2(7), SPTAN1(30), SRC(3), SYMPK(11), TJAP1(5), TJP1(25), TJP2(17), TJP3(12), VAPA(2), YES1(10), ZAK(12)	127031966	1911	355	1660	667	561	450	229	391	262	18	0.229	1.000	1.000
95	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(14), ACTA2(3), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADM(5), ARRB1(4), ARRB2(1), ATF1(6), ATF2(7), ATF3(1), ATF4(4), ATF5(2), ATP2A2(17), ATP2A3(13), CACNB3(3), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CNN1(5), CNN2(4), CORIN(21), CREB3(6), CRHR1(6), DGKZ(9), ETS2(5), FOS(5), GABPA(14), GABPB2(4), GBA2(15), GJA1(9), GNAQ(11), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), GSTO1(2), GUCA2B(3), GUCY1A3(33), IGFBP1(2), IGFBP2(3), IGFBP3(8), IGFBP4(4), IGFBP6(2), IL1B(5), IL6(7), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), MIB1(13), MYL2(2), MYL4(4), MYLK2(10), NFKB1(11), NOS1(31), NOS3(23), OXTR(3), PDE4B(13), PDE4D(9), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLCD1(10), PLCG1(19), PLCG2(28), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RAMP1(2), RAMP2(2), RAMP3(7), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RLN1(4), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SP1(7), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1)	108292599	1512	351	1467	517	519	233	188	342	224	6	0.0410	1.000	1.000
96	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	120	ABL1(31), ABLIM1(11), ABLIM2(7), ABLIM3(17), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CFL2(2), CXCL12(2), CXCR4(7), DCC(42), DPYSL2(11), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(6), EFNB1(6), EFNB2(1), EFNB3(11), EPHA1(11), EPHA2(12), EPHA3(70), EPHA4(26), EPHA5(47), EPHA6(28), EPHA7(45), EPHA8(19), EPHB1(38), EPHB2(16), EPHB3(12), EPHB4(15), EPHB6(15), FES(7), FYN(17), GNAI1(5), GNAI2(2), GNAI3(2), GSK3B(17), HRAS(4), ITGB1(13), L1CAM(17), LIMK1(8), LIMK2(13), LRRC4C(17), MAPK1(3), MAPK3(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NGEF(19), NRP1(12), NTN1(5), NTN4(10), NTNG1(17), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLXNA1(22), PLXNA2(26), PLXNA3(24), PLXNB1(22), PLXNB2(28), PLXNB3(25), PLXNC1(20), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RAC3(2), RASA1(24), RGS3(25), RND1(3), ROBO1(32), ROBO3(12), ROCK1(35), ROCK2(20), SEMA3A(21), SEMA3B(7), SEMA3C(18), SEMA3D(29), SEMA3E(22), SEMA3F(13), SEMA3G(10), SEMA4A(13), SEMA4B(5), SEMA4C(5), SEMA4D(18), SEMA4F(14), SEMA4G(11), SEMA5A(21), SEMA5B(26), SEMA6A(9), SEMA6B(8), SEMA6C(13), SEMA6D(15), SEMA7A(3), SLIT1(31), SLIT2(33), SLIT3(25), SRGAP1(25), SRGAP2(9), SRGAP3(21), UNC5A(9), UNC5B(10), UNC5C(17), UNC5D(22)	118638503	1730	349	1605	630	581	303	186	383	269	8	0.523	1.000	1.000
97	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(14), ACTA2(3), ACTN2(19), ACTN3(6), ACTN4(8), DES(6), DMD(85), FAM48A(13), MYBPC1(12), MYBPC2(16), MYBPC3(15), MYH3(46), MYH6(34), MYH7(28), MYH8(47), MYL2(2), MYL3(1), MYL4(4), MYL9(3), NEB(106), TMOD1(8), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(3), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(8), TPM3(7), TPM4(9), TTN(882), VIM(9)	78815721	1415	348	1302	416	398	292	173	420	113	19	0.000176	1.000	1.000
98	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	228	ACVR1(9), ACVR2B(14), AMHR2(4), BMP2(9), BMP7(15), BMPR1B(15), CCL11(2), CCL13(1), CCL15(2), CCL16(2), CCL17(1), CCL18(2), CCL22(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL4(1), CCL7(2), CCL8(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CD27(4), CD40(7), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(5), CSF1R(16), CSF2RB(13), CSF3(3), CSF3R(19), CX3CL1(5), CX3CR1(6), CXCL1(1), CXCL10(2), CXCL11(4), CXCL12(2), CXCL14(2), CXCL16(3), CXCL5(6), CXCL6(1), CXCL9(7), CXCR3(5), CXCR4(7), CXCR6(1), EDA(5), EDA2R(4), EDAR(8), EGF(8), EPO(1), EPOR(2), FAS(9), FASLG(3), FLT1(43), FLT3(36), FLT3LG(1), FLT4(18), GDF5(13), GH1(5), GH2(6), GHR(12), HGF(17), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL15(1), IL15RA(1), IL17A(3), IL17B(1), IL17RA(8), IL17RB(8), IL18(3), IL18R1(16), IL18RAP(12), IL19(3), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL1RAP(7), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL25(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL8(6), IL9(2), INHBA(21), INHBB(3), INHBC(4), INHBE(3), KDR(42), KITLG(3), LEP(1), LEPR(21), LIF(1), LIFR(41), LTA(1), LTBR(5), MPL(9), NGFR(5), OSM(4), OSMR(22), PDGFB(2), PDGFC(10), PDGFRA(64), PDGFRB(21), PF4(3), PLEKHO2(7), PPBP(6), PRL(4), PRLR(10), RELT(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10D(2), TNFRSF11A(6), TNFRSF11B(7), TNFRSF13B(7), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFRSF8(8), TNFRSF9(10), TNFSF10(3), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(4), TNFSF14(4), TNFSF15(3), TNFSF4(6), TNFSF8(6), TPO(36), TSLP(3), VEGFA(5), VEGFC(15), XCL1(1), XCL2(4), XCR1(6)	108443588	1477	337	1345	505	398	276	176	405	217	5	0.100	1.000	1.000
99	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	118	ALCAM(12), CADM1(18), CADM3(15), CD2(7), CD22(17), CD226(6), CD274(5), CD276(6), CD28(5), CD34(7), CD4(4), CD40(7), CD40LG(10), CD6(6), CD80(6), CD86(2), CD8A(2), CD8B(4), CDH15(3), CDH2(40), CDH3(9), CDH4(24), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CNTN1(31), CNTN2(13), CNTNAP1(15), CNTNAP2(39), CTLA4(5), ESAM(6), F11R(4), GLG1(15), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), ICAM1(4), ICAM2(6), ICAM3(3), ICOS(2), ICOSLG(5), ITGA4(20), ITGA6(16), ITGA8(20), ITGA9(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGB1(13), ITGB2(18), ITGB7(10), ITGB8(12), JAM2(2), JAM3(9), L1CAM(17), MAG(11), MPZ(2), MPZL1(7), NCAM1(18), NCAM2(29), NEGR1(4), NEO1(14), NFASC(41), NLGN1(21), NLGN2(5), NLGN3(11), NRCAM(21), NRXN1(46), NRXN2(24), NRXN3(35), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(36), PTPRF(23), PTPRM(48), PVR(2), PVRL1(9), PVRL2(5), PVRL3(5), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SELE(13), SELL(5), SELP(15), SIGLEC1(19), SPN(6), VCAM1(15), VCAN(74)	92717775	1317	332	1242	511	403	192	158	351	208	5	0.742	1.000	1.000
100	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	67	CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS2(10), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), FN3K(1), IMPA1(4), IMPA2(4), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5D(10), INPP5E(3), INPPL1(16), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), OCRL(21), PI4KA(29), PI4KB(5), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3C3(29), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PRKCA(8), PRKCG(24), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15)	76635767	1238	320	1061	443	308	350	146	262	162	10	0.497	1.000	1.000
101	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	100	ABL1(31), ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), ATM(237), ATR(53), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDC14A(14), CDC14B(6), CDC16(6), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(6), CDC26(1), CDC27(21), CDC6(10), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CHEK1(11), CREBBP(81), CUL1(17), DBF4(11), E2F2(7), E2F3(6), EP300(56), ESPL1(23), FZR1(4), GADD45G(1), GSK3B(17), HDAC1(5), HDAC2(8), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTTG1(2), RB1(139), RBL1(21), RBL2(24), RBX1(1), SFN(1), SKP1(2), SKP2(3), SMC1A(21), SMC1B(28), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	88095997	1339	319	1126	462	274	374	123	312	235	21	0.438	1.000	1.000
102	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	123	AXIN1(10), AXIN2(27), BTRC(11), CACYBP(4), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(6), CHD8(37), CREBBP(81), CSNK1A1(3), CSNK1A1L(9), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(14), CTNNBIP1(1), CUL1(17), CXXC4(2), DAAM1(10), DAAM2(20), DKK1(9), DKK4(8), DVL2(12), DVL3(10), EP300(56), FBXW11(13), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LEF1(9), LRP5(11), LRP6(34), MAP3K7(9), MAPK10(18), MAPK8(17), MAPK9(13), MMP7(10), MYC(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NKD1(6), NLK(12), PLCB1(23), PLCB3(15), PLCB4(23), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRICKLE1(24), PRICKLE2(18), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PSEN1(4), RAC1(2), RAC2(1), RAC3(2), RBX1(1), ROCK1(35), ROCK2(20), RUVBL1(9), SENP2(4), SFRP1(3), SFRP4(9), SFRP5(1), SIAH1(2), SKP1(2), TBL1X(9), TBL1XR1(11), TCF7(15), TCF7L1(8), VANGL2(9), WIF1(5), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	88915496	1212	315	1123	415	412	207	138	245	203	7	0.135	1.000	1.000
103	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	71	ABL1(31), ACTN1(13), ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGEF6(19), ARHGEF7(23), BCAR1(6), CAV1(1), CDC42(3), CDKN2A(9), CSE1L(10), DOCK1(24), EPHB2(16), FYN(17), GRB7(3), GRLF1(19), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGB3BP(3), MAP3K11(12), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MRAS(4), MYLK(33), MYLK2(10), P4HB(6), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CB(6), PKLR(12), PLCG1(19), PLCG2(28), PTEN(333), PTK2(24), RALA(8), RHO(5), ROCK1(35), ROCK2(20), SHC1(14), SOS1(16), SOS2(17), SRC(3), TERF2IP(4), TLN1(23), TLN2(17), VASP(4), WAS(4), ZYX(5)	76500668	1239	314	1060	477	241	336	159	279	209	15	0.882	1.000	1.000
104	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	143	ADORA1(18), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCBP2(14), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CCRL1(7), CCRL2(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CMKLR1(8), CNR1(13), CNR2(1), CX3CR1(6), CXCR3(5), CXCR4(7), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2R(11), F2RL2(8), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GPR17(3), GPR173(3), GPR3(3), GPR35(3), GPR37(15), GPR37L1(8), GPR4(7), GPR44(2), GPR50(9), GPR6(8), GPR63(7), GPR77(4), GPR83(7), GPR85(7), GPR87(12), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HTR1A(17), HTR1B(13), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LTB4R(2), MAS1(3), MC1R(2), MC3R(14), MC4R(7), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPN1SW(8), OPN3(7), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OR10A5(3), OR12D3(4), OR1C1(11), OR1F1(4), OR1Q1(5), OR2H1(5), OR7A5(6), OR8B8(6), OXTR(3), P2RY1(8), P2RY10(15), P2RY12(6), P2RY14(11), P2RY2(8), P2RY6(6), PPYR1(8), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), RGR(4), RHO(5), RRH(7), SSTR1(12), SSTR2(6), SSTR4(14), SUCNR1(6), TRHR(9)	70048968	1130	313	1052	433	429	189	143	259	110	0	0.0414	1.000	1.000
105	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	83	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRB1(4), CSNK1D(15), DRD1(9), DRD2(9), EGF(8), GJA1(9), GJD2(5), GNA11(8), GNAI1(5), GNAI2(2), GNAI3(2), GNAQ(11), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), HTR2B(7), HTR2C(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAP2K5(6), MAP3K2(9), MAPK1(3), MAPK3(4), MAPK7(6), NPR1(18), NPR2(17), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PLCB1(23), PLCB3(15), PLCB4(23), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), PRKX(3), SOS1(16), SOS2(17), SRC(3), TJP1(25), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10)	80580429	1167	311	1100	426	388	202	155	278	140	4	0.259	1.000	1.000
106	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	138	AKT1(11), AKT2(8), AKT3(8), BCL2L1(1), CBLB(17), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(81), CSF2RB(13), CSF3(3), CSF3R(19), EP300(56), EPO(1), EPOR(2), GH1(5), GH2(6), GHR(12), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL13RA2(17), IL15(1), IL15RA(1), IL19(3), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL9(2), IRF9(6), JAK1(22), JAK3(31), LEP(1), LEPR(21), LIF(1), LIFR(41), MPL(9), MYC(5), OSM(4), OSMR(22), PIAS1(4), PIAS2(5), PIAS3(10), PIAS4(2), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIM1(4), PRL(4), PRLR(10), PTPN11(41), PTPN6(4), SOCS2(4), SOCS4(1), SOCS5(12), SOCS7(1), SOS1(16), SOS2(17), SPRED1(10), SPRED2(10), SPRY1(10), SPRY2(2), SPRY4(7), STAM(4), STAM2(4), STAT1(17), STAT2(12), STAT3(10), STAT4(13), STAT5A(10), STAT5B(20), STAT6(4), TPO(36), TSLP(3), TYK2(5)	90741122	1150	308	1020	398	292	227	146	309	173	3	0.339	1.000	1.000
107	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	75	ABL1(31), ATM(237), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDAN1(9), CDC14A(14), CDC14B(6), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(6), CDC6(10), CDK2(5), CDK4(4), CDKN1A(2), CDKN2A(9), CHEK1(11), DTX4(8), E2F2(7), E2F3(6), E2F4(2), E2F5(6), EP300(56), ESPL1(23), GSK3B(17), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), HDAC8(3), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MPEG1(8), MPL(9), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTPRA(6), PTTG1(2), RB1(139), RBL1(21), SKP2(3), TBC1D8(11), TFDP1(10), TGFB1(2)	70105021	1071	305	894	379	211	323	100	245	174	18	0.497	1.000	1.000
108	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	139	ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADK(7), ADSL(13), ADSS(8), ADSSL1(6), AK1(2), AK5(10), AK7(8), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), FHIT(1), GART(5), GDA(7), GMPR(9), GMPR2(3), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NPR1(18), NPR2(17), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE10A(19), PDE11A(16), PDE1A(10), PDE1C(19), PDE2A(10), PDE3B(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6D(2), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PPAT(8), PRIM1(5), PRIM2(3), PRPS1L1(4), PRPS2(6), PRUNE(4), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), XDH(19)	111306915	1254	305	1194	425	369	190	192	303	199	1	0.122	1.000	1.000
109	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(27), ATM(237), ATR(53), BAI1(13), BID(2), CASP3(4), CASP8(20), CASP9(6), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG1(5), CCNG2(4), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN2A(9), CHEK1(11), CYCS(1), DDB2(1), EI24(1), FAS(9), GADD45G(1), GTSE1(5), IGF1(6), IGFBP3(8), MDM2(11), MDM4(7), PPM1D(6), PTEN(333), RCHY1(4), RFWD2(6), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(7), SERPINE1(10), SESN1(5), SESN2(9), SESN3(8), SFN(1), SIAH1(2), STEAP3(6), THBS1(14), TNFRSF10B(8), TP53I3(2), TP73(5), TSC2(17), ZMAT3(12)	40579033	973	304	747	361	130	357	112	203	152	19	0.667	1.000	1.000
110	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	58	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2L1(1), CDC42(3), CDK2(5), CDKN1B(6), CDKN2A(9), CREB1(3), CREB3(6), CREB5(8), EBP(6), ERBB4(65), F2RL2(8), GAB1(15), GSK3A(6), GSK3B(17), IGF1(6), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), MYC(5), NOLC1(9), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARD3(13), PARD6A(2), PDK1(7), PIK3CD(11), PPP1R13B(10), PREX1(27), PTEN(333), PTK2(24), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SLC2A4(8), SOS1(16), SOS2(17), TSC1(18), TSC2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	46022008	970	295	783	366	174	298	135	204	150	9	0.769	1.000	1.000
111	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	62	ADCY1(27), ADCY8(34), ARAF(10), ATF4(4), CACNA1C(35), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CREBBP(81), EP300(56), GNAQ(11), GRIA1(38), GRIA2(29), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), PLCB1(23), PLCB3(15), PLCB4(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R1A(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAP1A(2), RAP1B(2), RAPGEF3(8), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18)	62927923	962	294	898	372	321	209	106	198	125	3	0.612	1.000	1.000
112	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	99	ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), BCAR1(6), CDC42(3), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNND1(19), CXCL12(2), CXCR4(7), CYBB(6), ESAM(6), EZR(3), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), GRLF1(19), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), ITK(26), JAM2(2), JAM3(9), MAPK12(4), MAPK13(6), MAPK14(8), MLLT4(21), MMP2(18), MMP9(19), MSN(9), MYL2(2), MYL7(1), MYL9(3), NCF1(4), NCF2(10), NCF4(5), NOX1(4), NOX3(14), OCLN(2), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAC1(2), RAC2(1), RAP1A(2), RAP1B(2), RAPGEF3(8), RAPGEF4(12), RASSF5(6), RHOH(5), ROCK1(35), ROCK2(20), SIPA1(10), TXK(12), VASP(4), VAV1(24), VAV3(30), VCAM1(15), VCL(10)	74446439	990	293	921	367	316	170	102	240	157	5	0.738	1.000	1.000
113	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	117	ACACA(36), ACACB(40), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBLB(17), CBLC(3), CRKL(5), ELK1(4), EXOC7(4), FBP1(1), FBP2(5), FLOT1(7), FLOT2(2), FOXO1(8), G6PC(5), G6PC2(3), GCK(6), GSK3B(17), GYS1(6), GYS2(17), HRAS(4), IKBKB(9), INPP5D(10), INSR(21), IRS1(21), IRS4(36), LIPE(11), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MKNK1(4), MKNK2(7), PCK1(6), PCK2(6), PDE3A(21), PDE3B(10), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PKLR(12), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R3A(45), PPP1R3B(4), PPP1R3C(6), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACA(2), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCI(25), PRKCZ(4), PRKX(3), PTPN1(11), PTPRF(23), PYGB(15), PYGL(8), PYGM(12), RAPGEF1(19), RHEB(5), RHOQ(6), RPS6(3), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SLC2A4(8), SOCS2(4), SOCS4(1), SORBS1(15), SOS1(16), SOS2(17), SREBF1(8), TRIP10(5), TSC1(18), TSC2(17)	95576634	1113	292	1033	389	352	182	141	266	170	2	0.215	1.000	1.000
114	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	73	ABL1(31), ABL2(20), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CBLB(17), CBLC(3), CDKN1A(2), CDKN1B(6), CRKL(5), EGF(8), ELK1(4), ERBB3(32), ERBB4(65), EREG(3), GAB1(15), GSK3B(17), HBEGF(1), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYC(5), NCK1(1), NCK2(5), NRG1(33), NRG2(8), NRG3(18), NRG4(2), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SRC(3), STAT5A(10), STAT5B(20)	58299944	814	285	732	301	202	169	118	173	151	1	0.793	1.000	1.000
115	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	87	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), AKAP1(7), AKAP10(6), AKAP11(30), AKAP12(36), AKAP2(2), AKAP3(26), AKAP4(16), AKAP5(6), AKAP6(44), AKAP8(8), AKAP9(75), ARHGEF1(15), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(7), GNA13(3), GNA14(13), GNA15(6), GNAI2(2), GNAI3(2), GNAL(5), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), HRAS(4), IL18BP(4), ITPR1(43), KCNJ3(11), PALM2(1), PDE1A(10), PDE1B(11), PDE1C(19), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PLCB3(15), PPP3CA(5), PPP3CC(7), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKD3(19), RRAS(2), SLC9A1(12), USP5(10)	77410626	1001	282	934	362	306	177	118	225	172	3	0.322	1.000	1.000
116	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGAP1(3), ARHGAP4(7), ARHGEF11(24), BTK(12), CDC42(3), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(16), ITPR1(43), ITPR2(49), ITPR3(44), LIMK1(8), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDK1(7), PIK3CD(11), PIK3CG(41), PITX2(2), PPP1R13B(10), PTEN(333), RACGAP1(5), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), SAG(5), WASF1(6), WASL(18)	43799407	891	282	737	331	164	273	114	194	133	13	0.772	1.000	1.000
117	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	44	FN3K(1), IMPA1(4), IMPA2(4), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(16), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), MINPP1(6), MIOX(3), OCRL(21), PI4KA(29), PI4KB(5), PIK3C3(29), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15)	45248283	853	279	691	305	187	276	98	174	109	9	0.504	1.000	1.000
118	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	87	AKT1(11), AKT3(8), BCAR1(6), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(10), CAPN3(11), CAPN5(14), CAPN6(15), CAPN7(12), CAPN9(5), CAPNS1(4), CAV1(1), CAV2(4), CAV3(4), CDC42(3), CSK(5), DOCK1(24), FYN(17), GIT2(11), ILK(3), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK10(18), MAPK12(4), MAPK4(4), MAPK7(6), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(19), RHO(5), ROCK1(35), ROCK2(20), SDCCAG8(4), SEPP1(4), SHC1(14), SHC3(5), SORBS1(15), SOS1(16), SRC(3), TLN1(23), TNS1(39), VASP(4), VAV3(30), VCL(10), ZYX(5)	86986575	1001	277	949	379	291	145	108	263	185	9	0.896	1.000	1.000
119	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	68	ARAF(10), C7orf16(11), CACNA1A(28), CRHR1(6), GNA11(8), GNA12(7), GNA13(3), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GRIA1(38), GRIA2(29), GRIA3(15), GRID2(28), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), IGF1(6), IGF1R(22), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NOS1(31), NOS3(23), NPR1(18), NPR2(17), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB3(15), PLCB4(23), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), RYR1(70)	68687519	1000	276	947	376	351	158	122	230	136	3	0.616	1.000	1.000
120	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	72	ACVR1(9), ACVRL1(8), AKT1(11), AURKB(6), BUB1(16), CDKL1(6), CDKL2(16), CDS2(10), CLK1(10), CLK2(3), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), IMPA1(4), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MAP3K10(11), MOS(10), NEK1(20), NEK3(10), OCRL(21), PAK4(6), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CB(6), PIK3CG(41), PIM2(1), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28), PLK3(3), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKG1(18), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KB1(9), STK11(38), TGFBR1(20), VRK1(7)	66500774	914	276	827	314	280	185	108	201	138	2	0.383	1.000	1.000
121	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	58	ATM(237), CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CREB3(6), CREB3L1(6), CREB3L3(7), CREB3L4(5), E2F2(7), E2F3(6), E2F4(2), E2F5(6), GBA2(15), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MNAT1(4), MYC(5), MYT1(25), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLE(41), POLE2(6), PRIM1(5), RB1(139), RBL1(21), RPA1(12), RPA2(1), TFDP1(10), TFDP2(5)	45292935	774	273	641	270	135	232	78	189	124	16	0.350	1.000	1.000
122	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	87	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), CREB3(6), CREB3L1(6), CREB3L2(5), CREB3L3(7), CREB3L4(5), CREBBP(81), DCT(22), DVL2(12), DVL3(10), EDN1(3), EDNRB(19), EP300(56), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GSK3B(17), HRAS(4), KITLG(3), LEF1(9), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MC1R(2), MITF(19), PLCB1(23), PLCB3(15), PLCB4(23), POMC(4), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), TCF7(15), TCF7L1(8), TYR(12), TYRP1(6), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	61444974	908	273	846	358	339	162	112	178	117	0	0.425	1.000	1.000
123	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	84	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ATF4(4), CACNA1C(35), CACNA1D(29), CACNA1F(37), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDC42(3), CGA(3), ELK1(4), FSHB(6), GNA11(8), GNAQ(11), GNRH1(4), GNRHR(9), HBEGF(1), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), LHB(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK9(13), MMP14(7), MMP2(18), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB3(15), PLCB4(23), PLD1(19), PLD2(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCD(15), PRKX(3), PTK2B(13), SOS1(16), SOS2(17), SRC(3)	78223281	1010	272	966	341	331	170	125	232	149	3	0.0807	1.000	1.000
124	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(64), ASH2L(7), C17orf79(1), CARM1(3), CTCFL(19), DOT1L(10), EED(2), EHMT1(11), EHMT2(10), EZH1(9), EZH2(51), FBXO11(15), HCFC1(13), HSF4(5), JMJD4(2), JMJD6(9), KDM6A(27), MEN1(32), MLL(58), MLL2(67), MLL3(88), MLL4(41), MLL5(32), NSD1(29), OGT(10), PAXIP1(22), PPP1CA(2), PPP1CB(6), PPP1CC(2), PRDM2(36), PRDM7(6), PRDM9(43), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), RBBP5(4), SATB1(17), SETD1A(21), SETD7(9), SETD8(6), SETDB1(19), SETDB2(6), SETMAR(4), SMYD3(6), STK38(11), SUV39H1(4), SUV39H2(7), SUV420H1(17), SUV420H2(1), SUZ12(5), WHSC1(28), WHSC1L1(10)	75004455	939	270	822	291	254	209	79	206	179	12	0.178	1.000	1.000
125	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADK(7), ADSL(13), ADSS(8), AK1(2), AK5(10), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), ATP1B1(4), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), FHIT(1), GART(5), GDA(7), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NPR1(18), NPR2(17), NT5C(1), NT5E(7), NT5M(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE1A(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6B(11), PDE6C(12), PDE7B(6), PDE8A(6), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), PPAT(8), PRPS1L1(4), PRPS2(6), PRUNE(4), RRM1(3), RRM2(5)	85680138	982	270	935	330	294	148	138	245	156	1	0.230	1.000	1.000
126	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(11), AKT2(8), AKT3(8), BCR(12), BTK(12), CD19(10), CDKN2A(9), DAPP1(3), FLOT1(7), FLOT2(2), GAB1(15), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), PDK1(7), PHF11(3), PITX2(2), PLCG2(28), PPP1R13B(10), PREX1(27), PTEN(333), PTPRC(36), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SAG(5), SYK(8), TEC(10), VAV1(24)	35190298	798	269	662	287	159	272	108	154	96	9	0.437	1.000	1.000
127	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(44), ABCA10(36), ABCA12(82), ABCA13(72), ABCA3(24), ABCA4(35), ABCA5(36), ABCA6(35), ABCA7(22), ABCA8(32), ABCA9(39), ABCB1(35), ABCB10(11), ABCB11(19), ABCB4(28), ABCB5(29), ABCB6(8), ABCB7(7), ABCB8(10), ABCB9(7), ABCC1(25), ABCC10(20), ABCC11(17), ABCC12(27), ABCC2(23), ABCC3(11), ABCC4(24), ABCC5(22), ABCC6(13), ABCC8(25), ABCC9(26), ABCD1(5), ABCD2(21), ABCD3(5), ABCD4(10), ABCG1(8), ABCG2(17), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(21), TAP1(9), TAP2(16)	76282590	984	268	966	304	255	148	112	294	164	11	0.0126	1.000	1.000
128	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	63	ACP1(5), ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), BAIAP2(7), CDC42(3), CREBBP(81), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNND1(19), EP300(56), FARP2(13), FER(18), FGFR1(22), FYN(17), IGF1R(22), INSR(21), IQGAP1(31), LEF1(9), LMO7(33), MAP3K7(9), MAPK1(3), MAPK3(4), MLLT4(21), NLK(12), PARD3(13), PTPN1(11), PTPN6(4), PTPRB(21), PTPRF(23), PTPRJ(18), PTPRM(48), PVRL1(9), PVRL2(5), PVRL3(5), PVRL4(11), RAC1(2), RAC2(1), RAC3(2), SNAI1(6), SNAI2(11), SORBS1(15), SRC(3), SSX2IP(9), TCF7(15), TCF7L1(8), TGFBR1(20), TGFBR2(26), TJP1(25), VCL(10), WAS(4), WASF1(6), WASF2(5), WASF3(17), WASL(18), YES1(10)	68485326	953	267	853	328	275	184	116	209	166	3	0.224	1.000	1.000
129	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	111	ARAF(10), BID(2), CASP3(4), CD244(7), CD247(3), CD48(2), FAS(9), FASLG(3), FCGR3A(5), FCGR3B(2), FYN(17), GZMB(5), HCST(2), HLA-C(13), HLA-E(4), HLA-G(13), HRAS(4), ICAM1(4), ICAM2(6), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), ITGAL(21), ITGB2(18), KIR2DL1(10), KIR2DL4(5), KIR3DL1(10), KIR3DL2(7), KLRC1(2), KLRC2(2), KLRC3(8), KLRD1(3), KLRK1(8), LAT(3), LCK(9), LCP2(10), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MICB(4), NCR1(3), NCR2(2), NCR3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), PAK1(11), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRF1(8), PRKCA(8), PRKCG(24), PTK2B(13), PTPN11(41), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), SH2D1A(3), SH2D1B(1), SH3BP2(7), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SYK(8), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10D(2), TNFSF10(3), TYROBP(1), ULBP1(7), ULBP2(2), ULBP3(6), VAV1(24), VAV3(30), ZAP70(12)	66576765	842	265	760	304	241	160	99	194	146	2	0.499	1.000	1.000
130	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	43	AKT1(11), AKT2(8), AKT3(8), BRD4(22), CAP1(5), CDC42(3), CDKN2A(9), F2RL2(8), FLOT1(7), FLOT2(2), GSK3A(6), GSK3B(17), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), LNPEP(23), MAPK1(3), MAPK3(4), PARD3(13), PARD6A(2), PDK1(7), PIK3CD(11), PPYR1(8), PTEN(333), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SERPINB6(4), SFN(1), SHC1(14), SLC2A4(8), SORBS1(15), SOS1(16), SOS2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	33506407	748	262	587	257	139	259	93	150	98	9	0.187	1.000	1.000
131	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	75	AIFM1(13), AKT1(11), AKT2(8), AKT3(8), APAF1(27), ATM(237), BAD(1), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CAPN1(2), CAPN2(10), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CSF2RB(13), CYCS(1), DFFA(6), DFFB(2), ENDOG(3), FADD(1), FAS(9), FASLG(3), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL3(6), IRAK1(6), IRAK2(11), IRAK3(11), IRAK4(8), MAP3K14(6), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), NTRK1(17), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), RIPK1(7), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10D(2), TNFRSF1A(4), TNFSF10(3), TRAF2(8)	52292264	766	261	660	279	175	195	78	178	132	8	0.750	1.000	1.000
132	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	86	ACTB(4), BAD(1), BCL2(2), CABIN1(24), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(9), CD3E(2), CD69(4), CDKN1A(2), CNR1(13), CREBBP(81), CSNK2A1(7), CSNK2B(2), CTLA4(5), EGR2(16), EGR3(6), EP300(56), FCER1A(6), FCGR3A(5), FOS(5), FOSL1(1), GATA3(17), GATA4(4), GRLF1(19), GSK3A(6), GSK3B(17), HRAS(4), ICOS(2), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL13(2), IL1B(5), IL2(5), IL2RA(6), IL3(6), IL4(5), IL6(7), IL8(6), ITK(26), KPNA5(12), MAPK14(8), MAPK8(17), MAPK9(13), MEF2A(7), MEF2D(3), MYF5(7), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB2(6), NFKBIB(5), NFKBIE(5), NPPB(5), NUP214(22), OPRD1(6), P2RX7(13), PAK1(11), PIN1(2), PPIA(1), PPP3CB(11), PPP3CC(7), PPP3R1(4), PTPRC(36), RELA(10), RPL13A(1), SFN(1), SLA(8), SP1(7), SP3(13), TGFB1(2), TNF(2), TRAF2(8), TRPV6(20), VAV1(24), VAV3(30), XPO5(8)	57242474	798	260	737	280	242	195	85	164	112	0	0.162	1.000	1.000
133	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	76	ACVR1(9), ACVR2B(14), ACVRL1(8), AMHR2(4), BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BMPR1B(15), CHRD(16), COMP(6), CREBBP(81), CUL1(17), DCN(9), E2F4(2), E2F5(6), EP300(56), FST(5), GDF5(13), GDF6(7), ID1(2), ID4(1), IFNG(3), INHBA(21), INHBB(3), INHBC(4), INHBE(3), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(3), MAPK3(4), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), RBL1(21), RBL2(24), RBX1(1), ROCK1(35), ROCK2(20), RPS6KB1(9), RPS6KB2(6), SKP1(2), SMAD1(10), SMAD5(4), SMAD7(2), SMAD9(7), SMURF1(9), SMURF2(7), SP1(7), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNF(2), ZFYVE16(23), ZFYVE9(23)	59658981	799	260	734	302	262	137	88	177	129	6	0.741	1.000	1.000
134	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	52	BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BTRC(11), CSNK1A1(3), CSNK1A1L(9), CSNK1D(15), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(7), DHH(4), FBXW11(13), GLI1(22), GLI2(28), GLI3(44), GSK3B(17), HHIP(16), IHH(5), LRP2(130), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), PTCH1(143), PTCH2(21), RAB23(4), SHH(3), SMO(13), STK36(20), SUFU(5), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	37232771	699	255	610	259	226	157	82	136	95	3	0.457	1.000	1.000
135	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	30	ACTA1(14), CRKL(5), DOCK1(24), ELK1(4), FOS(5), GAB1(15), HGF(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAP4K1(7), MAPK1(3), MAPK3(4), MAPK8(17), PAK1(11), PTEN(333), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAP1A(2), RAP1B(2), RASA1(24), SOS1(16), SRC(3), STAT3(10)	24721098	642	255	486	260	76	264	81	140	73	8	0.870	1.000	1.000
136	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHX58(6), ENPP1(17), ENPP3(12), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), G6PC(5), G6PC2(3), GAA(14), GANC(9), GBA(4), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), IFIH1(22), LYZL1(4), MGAM(26), MOV10L1(23), NUDT5(1), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SI(28), SKIV2L2(13), SMARCA2(22), SMARCA5(18), TREH(6), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UXS1(9)	85635782	923	252	856	275	257	158	110	220	175	3	0.0469	1.000	1.000
137	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	101	A4GNT(7), ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG6(5), ALG8(13), ALG9(8), B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT5(5), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(10), CHST11(6), CHST12(6), CHST14(1), CHST2(13), CHST3(7), CHST4(8), CHSY1(14), DAD1(3), DDOST(4), EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), FUT11(3), FUT8(11), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GANAB(13), GCNT1(9), GCNT3(6), GCNT4(14), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), NDST1(10), NDST2(10), NDST3(19), NDST4(13), OGT(10), RPN1(4), RPN2(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(6), STT3B(11), UST(12), XYLT1(14)	69881365	834	250	790	316	280	146	90	196	122	0	0.923	1.000	1.000
138	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	82	AKT1(11), AKT2(8), AKT3(8), BCL10(8), CBLB(17), CBLC(3), CD247(3), CD28(5), CD3D(5), CD3E(2), CD4(4), CD40LG(10), CD8A(2), CD8B(4), CDC42(3), CDK4(4), CHUK(27), CTLA4(5), FOS(5), FYN(17), GRAP2(7), HRAS(4), ICOS(2), IFNG(3), IKBKB(9), IKBKG(2), IL10(2), IL2(5), IL4(5), ITK(26), JUN(2), LAT(3), LCK(9), LCP2(10), MALT1(13), MAP3K14(6), MAP3K8(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDCD1(2), PDK1(7), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCQ(16), PTPN6(4), PTPRC(36), RASGRP1(8), SOS1(16), SOS2(17), TEC(10), TNF(2), VAV1(24), VAV3(30), ZAP70(12)	59481116	729	248	675	242	209	148	93	162	117	0	0.118	1.000	1.000
139	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(25), BDKRB1(4), BDKRB2(6), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(17), C2(10), C3(25), C3AR1(12), C4A(3), C4B(2), C4BPA(12), C4BPB(1), C5(25), C5AR1(8), C6(27), C7(11), C8A(14), C8B(23), C8G(1), C9(12), CD46(4), CD55(8), CFB(7), CFH(32), CFI(9), CPB2(11), CR1(20), CR2(22), F10(5), F11(8), F12(5), F13A1(15), F13B(12), F2(10), F2R(11), F3(2), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), KNG1(9), MASP1(23), MASP2(10), MBL2(3), PLAT(11), PLAU(7), PLAUR(9), PLG(27), PROC(3), PROS1(12), SERPINA1(9), SERPINA5(9), SERPINC1(8), SERPIND1(6), SERPINE1(10), SERPINF2(4), SERPING1(7), TFPI(9), THBD(3), VWF(36)	63684208	814	246	775	288	205	132	116	217	140	4	0.598	1.000	1.000
140	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(14), CREBBP(81), DUSP1(7), EHHADH(15), EP300(56), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(4), ME1(14), MRPL11(1), MYC(5), NCOA1(15), NCOR1(35), NCOR2(44), NFKBIA(1), NR1H3(16), NR2F1(6), NRIP1(18), PDGFA(2), PPARA(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PTGS2(10), RB1(139), RELA(10), RXRA(8), SP1(7), SRA1(3), STAT5A(10), STAT5B(20), TNF(2)	39451625	642	246	519	221	145	166	58	129	136	8	0.465	1.000	1.000
141	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(4), AKT1(11), AKT2(8), AKT3(8), BAD(1), BTK(12), CDKN2A(9), DAPP1(3), GSK3A(6), GSK3B(17), IARS(10), IGFBP1(2), INPP5D(10), PDK1(7), PPP1R13B(10), PTEN(333), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SOS1(16), SOS2(17), TEC(10), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	22493265	586	242	449	217	83	238	68	112	76	9	0.453	1.000	1.000
142	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(31), ATM(237), ATR(53), CCNA1(18), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), DHFR(1), GSK3B(17), HDAC1(5), RB1(139), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2)	20217609	576	238	441	222	95	203	42	116	101	19	0.744	1.000	1.000
143	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	76	ATF2(7), CHUK(27), CREB1(3), DAXX(18), ELK1(4), FOS(5), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP3K9(11), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAP4K5(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK4(4), MAPK7(6), MAPK8(17), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MKNK2(7), MYC(5), NFKB1(11), NFKBIA(1), PAK1(11), PAK2(15), RAC1(2), RELA(10), RIPK1(7), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KB1(9), RPS6KB2(6), SHC1(14), SP1(7), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8)	58631309	749	238	683	220	203	145	103	160	136	2	0.0178	1.000	1.000
144	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	19	ATM(237), ATR(53), BRCA1(32), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(11), EP300(56), MDM2(11), MYT1(25), PRKDC(85), RPS6KA1(9), YWHAH(5), YWHAQ(1)	26794079	566	237	457	206	100	173	53	124	104	12	0.666	1.000	1.000
145	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	76	ANPEP(19), CD14(6), CD19(10), CD1A(6), CD1B(6), CD1C(5), CD1D(6), CD2(7), CD22(17), CD33(3), CD34(7), CD36(3), CD37(4), CD38(5), CD3D(5), CD3E(2), CD4(4), CD44(6), CD5(9), CD55(8), CD7(6), CD8A(2), CD8B(4), CD9(3), CR1(20), CR2(22), CSF1(5), CSF1R(16), CSF3(3), CSF3R(19), DNTT(13), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(36), FLT3LG(1), GP5(9), GP9(1), GYPA(8), HLA-DRB1(7), HLA-DRB5(4), IL11(6), IL11RA(4), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL2RA(6), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL7(4), IL7R(13), ITGA1(12), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGAM(14), ITGB3(16), KITLG(3), MME(27), MS4A1(7), TFRC(7), THPO(6), TNF(2), TPO(36)	52078117	645	236	596	222	188	103	85	179	86	4	0.132	1.000	1.000
146	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(40), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ADIPOR1(2), ADIPOR2(6), AKT1(11), AKT2(8), AKT3(8), CAMKK1(2), CAMKK2(9), CD36(3), CHUK(27), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), G6PC(5), G6PC2(3), IKBKB(9), IKBKG(2), IRS1(21), IRS4(36), JAK1(22), JAK3(31), LEP(1), LEPR(21), MAPK10(18), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NPY(6), PCK1(6), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(16), PTPN11(41), RELA(10), RXRA(8), RXRB(8), RXRG(11), SLC2A1(7), SLC2A4(8), STAT3(10), STK11(38), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5)	52844868	728	236	639	227	205	167	95	163	97	1	0.0142	1.000	1.000
147	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	49	ACTG1(6), APAF1(27), ARHGDIB(5), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), GSN(4), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK8(17), MDM2(11), NFKB1(11), NFKBIA(1), NUMA1(26), PAK2(15), PRKCD(15), PRKDC(85), PSEN1(4), PSEN2(6), PTK2(24), RASA1(24), RB1(139), RELA(10), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8)	44528430	682	235	571	224	148	191	58	149	126	10	0.349	1.000	1.000
148	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(11), EIF4A2(12), EIF4G1(19), EIF4G2(16), EIF4G3(19), GHR(12), IRS1(21), MAPK1(3), MAPK14(8), MAPK3(4), MKNK1(4), PABPC1(8), PDK2(9), PDPK1(4), PRKCA(8), PTEN(333), RPS6KB1(9)	16591007	500	234	359	196	55	217	66	97	57	8	0.733	1.000	1.000
149	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(237), BMPR1B(15), CCND2(3), CDK4(4), CDKN1B(6), DAZL(3), DMC1(7), EGR1(14), ESR2(8), FSHR(19), GJA4(3), INHA(6), MLH1(68), MSH5(8), NCOR1(35), NR5A1(5), NRIP1(18), PGR(16), PRLR(10), PTGER2(2), SMPD1(10), VDR(4), ZP2(16)	22763313	517	234	413	177	99	157	44	112	97	8	0.375	1.000	1.000
150	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	92	AKT1(11), AKT2(8), AKT3(8), CASP8(20), CCL4(1), CD14(6), CD40(7), CD80(6), CD86(2), CHUK(27), CXCL10(2), CXCL11(4), CXCL9(7), FADD(1), FOS(5), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IKBKB(9), IKBKE(9), IKBKG(2), IL12A(2), IL12B(1), IL1B(5), IL6(7), IL8(6), IRAK1(6), IRAK4(8), IRF3(4), IRF5(6), JUN(2), LBP(8), LY96(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K7(9), MAP3K8(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), RAC1(2), RELA(10), RIPK1(7), SPP1(4), STAT1(17), TBK1(12), TICAM1(15), TIRAP(5), TLR1(11), TLR2(12), TLR3(15), TLR4(18), TLR5(9), TLR6(14), TLR7(18), TLR8(20), TLR9(16), TNF(2), TOLLIP(5), TRAF3(12), TRAF6(4)	55882965	699	229	660	221	177	124	80	195	121	2	0.175	1.000	1.000
151	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(11), EIF4A2(12), EIF4B(5), EIF4G1(19), EIF4G2(16), EIF4G3(19), FKBP1A(2), MKNK1(4), PDK2(9), PDPK1(4), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9), TSC1(18), TSC2(17)	15782744	484	229	346	192	56	220	55	85	60	8	0.721	1.000	1.000
152	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ALG6(5), CCKBR(16), CCR2(7), CCR3(11), CCR5(11), CELSR1(28), CELSR2(33), CELSR3(28), CHRM2(29), CHRM3(23), CIDEB(1), CXCR3(5), EDNRA(9), EMR2(11), EMR3(19), F2R(11), FSHR(19), GHRHR(2), GNRHR(9), GPR116(21), GPR132(6), GPR133(16), GPR143(4), GPR17(3), GPR18(5), GPR55(2), GPR56(6), GPR61(12), GPR77(4), GPR84(8), GPR88(4), GRM1(37), GRPR(4), HRH4(6), LGR6(9), LPHN2(30), LPHN3(30), NTSR1(5), OR2M4(17), OR8G1(3), OR8G2(9), PTGFR(8), SMO(13), SSTR2(6), TAAR5(10), VN1R1(7)	38404100	562	228	505	207	179	106	52	140	84	1	0.543	1.000	1.000
153	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(11), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), GSK3B(17), IGF1(6), IGF1R(22), INPPL1(16), PDK2(9), PDPK1(4), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9)	10971766	456	227	319	186	45	223	54	76	50	8	0.875	1.000	1.000
154	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	18	ATM(237), ATR(53), BRCA1(32), BRCA2(99), CHEK1(11), FANCA(12), FANCC(8), FANCE(4), FANCF(4), FANCG(7), HUS1(8), MRE11A(20), RAD1(2), RAD17(9), RAD50(30), RAD9A(1), TREX1(3)	27772822	540	226	420	202	67	169	44	137	111	12	0.892	1.000	1.000
155	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CDK2(5), CDK4(4), CHEK1(11), MYT1(25), RB1(139), YWHAH(5)	11283140	454	223	335	156	73	171	29	99	66	16	0.291	1.000	1.000
156	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	61	ADAM10(8), ADAM17(13), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), CASP3(4), CDC42(3), CHUK(27), CSK(5), CXCL1(1), F11R(4), GIT1(4), HBEGF(1), IGSF5(16), IKBKB(9), IKBKG(2), IL8(6), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP3K14(6), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NOD1(10), PAK1(11), PLCG1(19), PLCG2(28), PTPN11(41), PTPRZ1(43), RAC1(2), RELA(10), SRC(3), TCIRG1(7), TJP1(25)	43103119	529	221	466	169	135	140	64	120	69	1	0.0819	1.000	1.000
157	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(11), BCAR1(6), CDKN1B(6), ILK(3), ITGB1(13), MAPK1(3), MAPK3(4), PDK2(9), PDPK1(4), PTEN(333), PTK2(24), SHC1(14), SOS1(16)	9918770	446	221	310	175	30	214	56	80	57	9	0.732	1.000	1.000
158	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(11), AKT2(8), AKT3(8), BPNT1(9), ILK(3), MAPK1(3), MAPK3(4), PDK1(7), PIK3CD(11), PTEN(333), PTK2B(13), RBL2(24), SHC1(14), SOS1(16)	11890511	464	221	327	176	42	212	57	88	56	9	0.757	1.000	1.000
159	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(27), ATM(237), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDKN1A(2), MDM2(11), PCNA(5), RB1(139), TIMP3(11)	11838531	451	215	326	168	61	176	30	99	69	16	0.562	1.000	1.000
160	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	60	AGTR1(14), AGTR2(17), ATP8A1(16), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CX3CR1(6), CXCR3(5), CXCR4(7), CXCR6(1), EDNRA(9), EDNRB(19), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(4), GRPR(4), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), NMBR(4), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), PPYR1(8), SSTR1(12), SSTR2(6), SSTR4(14), TAC4(4), TACR1(9), TACR2(4), TACR3(18), TRHR(9)	31395115	502	215	459	196	179	96	53	126	48	0	0.370	1.000	1.000
161	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	35	AKT1(11), ASAH1(4), ATF1(6), CAMP(1), CREB1(3), CREB3(6), CREB5(8), CREBBP(81), CRKL(5), DAG1(10), EGR1(14), EGR2(16), EGR3(6), EGR4(3), ELK1(4), FRS2(6), GNAQ(11), JUN(2), MAP1B(51), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NTRK1(17), OPN1LW(4), PIK3C2G(21), PIK3CD(11), PTPN11(41), RPS6KA3(16), SHC1(14), SRC(3), TERF2IP(4)	28006832	452	206	402	193	104	99	58	109	79	3	0.968	1.000	1.000
162	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(11), APAF1(27), ATM(237), BAD(1), BCL2(2), BCL2L1(1), BID(2), CASP3(4), CASP6(3), CASP7(3), CASP9(6), CYCS(1), EIF2S1(3), PRKCA(8), PTK2(24), PXN(2), STAT1(17), TLN1(23)	18172119	375	204	297	155	61	127	36	83	59	9	0.947	1.000	1.000
163	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	39	ADAM17(13), APH1A(2), CREBBP(81), CTBP1(5), CTBP2(14), DLL1(10), DLL3(7), DLL4(7), DTX1(6), DTX2(10), DTX3(3), DTX3L(11), DTX4(8), DVL2(12), DVL3(10), EP300(56), HDAC1(5), HDAC2(8), HES1(2), JAG1(16), LFNG(6), MAML1(12), MAML2(9), MAML3(4), MFNG(1), NCOR2(44), NCSTN(6), NOTCH2(35), NOTCH3(31), NOTCH4(20), NUMB(10), NUMBL(6), PSEN1(4), PSEN2(6), PSENEN(2), PTCRA(5), RBPJL(11), RFNG(1), SNW1(10)	37843484	509	204	453	230	151	98	62	88	109	1	0.995	1.000	1.000
164	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	64	AKT1(11), AKT2(8), AKT3(8), BTK(12), FCER1A(6), FYN(17), GAB2(10), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(10), LAT(3), LCP2(10), LYN(13), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MS4A2(6), PDK1(7), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PRKCA(8), PRKCD(15), PRKCE(6), RAC1(2), RAC2(1), RAC3(2), SOS1(16), SOS2(17), SYK(8), TNF(2), VAV1(24), VAV3(30)	41513462	534	204	504	178	160	110	68	125	71	0	0.133	1.000	1.000
165	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(14), AKT1(11), BDKRB2(6), CALM2(1), CALM3(1), CAV1(1), CHRM1(4), CHRNA1(12), FLT1(43), FLT4(18), KDR(42), NOS3(23), PDE2A(10), PDE3A(21), PDE3B(10), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKG1(18), PRKG2(12), RYR2(138), SLC7A1(6), SYT1(14), TNNI1(2)	25500072	442	203	424	158	119	97	52	112	60	2	0.395	1.000	1.000
166	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(31), ATM(237), BRCA1(32), CDKN1A(2), CHEK1(11), JUN(2), MAPK8(17), MDM2(11), MRE11A(20), NFKB1(11), NFKBIA(1), RAD50(30), RBBP8(15), RELA(10), TP73(5)	19029331	435	201	343	177	69	148	32	95	82	9	0.974	1.000	1.000
167	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	52	AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CAT(8), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADHA(12), KMO(16), KYNU(9), MAOA(7), MAOB(9), SDS(3), TDO2(11), TPH1(4), WARS(4), WARS2(7)	37067885	469	200	443	141	155	84	50	127	52	1	0.0340	1.000	1.000
168	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(7), AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PRIM1(5), PRIM2(3), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), TK1(2), TK2(3), TXNRD1(9), TXNRD2(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UPB1(9), UPP1(5), UPP2(6), UPRT(7)	56169458	575	199	549	165	152	92	91	153	87	0	0.00515	1.000	1.000
169	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	62	AKT1(11), AKT2(8), AKT3(8), BAD(1), CASP9(6), CDC42(3), HRAS(4), KDR(42), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPKAPK2(5), MAPKAPK3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NOS3(23), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCA(8), PRKCG(24), PTGS2(10), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), SH2D2A(5), SHC2(2), SPHK1(3), SPHK2(5), SRC(3), VEGFA(5)	41750426	487	199	448	195	174	75	60	98	80	0	0.806	1.000	1.000
170	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	56	AKT1(11), AKT2(8), AKT3(8), BCL10(8), BLNK(2), BTK(12), CD19(10), CD22(17), CD72(4), CD79A(6), CD79B(3), CHUK(27), CR2(22), FCGR2B(2), FOS(5), GSK3B(17), HRAS(4), IFITM1(2), IKBKB(9), IKBKG(2), INPP5D(10), JUN(2), LILRB3(8), LYN(13), MALT1(13), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RASGRP3(9), SYK(8), VAV1(24), VAV3(30)	43111326	507	199	476	163	162	89	67	112	77	0	0.0574	1.000	1.000
171	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(5), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CFLAR(3), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), PTPN13(23), RB1(139), RIPK2(5), SPTAN1(30)	26633770	455	198	384	160	71	136	38	114	86	10	0.749	1.000	1.000
172	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	51	AXIN1(10), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), DVL2(12), DVL3(10), FBXW2(6), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LDLR(11), MAPK10(18), MAPK9(13), MYC(5), PAFAH1B1(6), PLAU(7), PPP2R5C(6), PPP2R5E(8), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), RAC1(2), SFRP4(9), TCF7(15), WNT10A(3), WNT10B(6), WNT11(6), WNT2(4), WNT2B(8), WNT3(7), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4)	30538721	470	197	428	172	166	98	47	83	75	1	0.286	1.000	1.000
173	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	15	ABCB1(35), AKT1(11), ATM(237), CDKN1A(2), CPB2(11), CSNK1A1(3), CSNK1D(15), FHL2(3), HIF1A(16), IGFBP3(8), MAPK8(17), MDM2(11), NFKBIB(5), NQO1(1)	12809774	375	195	300	125	59	128	34	91	55	8	0.314	1.000	1.000
174	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	53	ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), CARM1(3), DBH(9), DCT(22), DDC(5), ECH1(2), ESCO1(22), ESCO2(18), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HEMK1(1), HGD(6), HPD(7), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), MYST3(34), MYST4(33), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SH3GLB1(6), TAT(16), TPO(36), TYR(12), TYRP1(6), WBSCR22(2)	39403230	474	194	426	176	135	95	56	124	63	1	0.565	1.000	1.000
175	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	55	AADAT(2), AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), AFMID(3), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CARM1(3), CAT(8), CYP1A1(10), CYP1A2(11), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADH(2), HADHA(12), HEMK1(1), HSD17B10(3), HSD17B4(9), INMT(4), KMO(16), KYNU(9), LCMT1(1), LCMT2(6), LNX1(19), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), NFX1(11), OGDH(14), OGDHL(16), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), TDO2(11), TPH1(4), TPH2(12), WARS(4), WARS2(7), WBSCR22(2)	40159518	432	193	411	152	132	72	56	117	55	0	0.419	1.000	1.000
176	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(7), CDC40(7), CLK2(3), CLK3(8), COL2A1(20), CPSF1(15), CPSF2(10), CPSF3(9), CPSF4(5), CSTF1(5), CSTF2(2), CSTF2T(14), CSTF3(13), DDIT3(5), DDX1(15), DDX20(7), DHX15(10), DHX16(20), DHX38(14), DHX9(13), DICER1(25), DNAJC8(5), FUS(2), GIPC1(4), LSM2(1), METTL3(6), NCBP1(12), NCBP2(2), NONO(13), NUDT21(1), NXF1(11), PABPN1(2), PAPOLA(8), PHF5A(1), POLR2A(14), PPM1G(4), PRPF18(5), PRPF3(9), PRPF4(10), PRPF4B(22), PRPF8(19), PSKH1(2), PTBP1(4), PTBP2(14), RBM17(6), RBM5(15), RNGTT(7), RNMT(6), RNPS1(2), SF3A1(11), SF3A2(5), SF3A3(1), SF3B1(18), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(3), SNRPA1(2), SNRPB(3), SNRPB2(3), SNRPD1(2), SNRPD3(2), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(9), SRPK2(12), SRRM1(18), SUPT5H(20), TXNL4A(2), U2AF1(4), U2AF2(8), XRN2(12)	69448641	603	193	568	195	161	89	64	159	129	1	0.811	1.000	1.000
177	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	25	ARHGDIB(5), CASP2(8), CASP3(4), CASP8(20), CRADD(4), DFFA(6), DFFB(2), FADD(1), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MADD(26), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), RB1(139), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TRAF2(8)	24411734	441	193	369	153	88	126	32	100	84	11	0.635	1.000	1.000
178	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	41	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), BCR(12), BLNK(2), BTK(12), CD19(10), CD22(17), CR2(22), CSK(5), DAG1(10), FLOT1(7), FLOT2(2), GSK3A(6), GSK3B(17), INPP5D(10), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP4K1(7), MAPK1(3), MAPK3(4), NFATC2(12), PDK1(7), PIK3CD(11), PLCG2(28), PPP1R13B(10), PPP3CA(5), PPP3CB(11), PPP3CC(7), PTPRC(36), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24)	43688973	531	190	511	156	168	93	69	119	80	2	0.00950	1.000	1.000
179	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(7), ACADL(6), ACADM(12), ACOX1(11), ACOX2(8), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP27A1(4), CYP4A11(8), CYP4A22(13), CYP7A1(14), CYP8B1(10), DBI(2), EHHADH(15), FABP1(2), FABP2(9), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FABP7(1), FADS2(12), GK(5), GK2(16), HMGCS2(6), ILK(3), LPL(12), ME1(14), MMP1(6), NR1H3(16), PCK1(6), PCK2(6), PDPK1(4), PLTP(12), PPARA(7), PPARD(5), PPARG(4), RXRA(8), RXRB(8), RXRG(11), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(7), SLC27A4(3), SLC27A5(9), SLC27A6(20), SORBS1(15), UBC(7), UCP1(8)	44220571	507	189	468	144	162	67	75	131	72	0	0.00655	1.000	1.000
180	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(27), BAD(1), BAK1(2), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(18), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), GZMB(5), HELLS(13), IKBKB(9), IKBKG(2), IRF1(6), IRF2(10), IRF3(4), IRF4(5), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP3K1(21), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), NFKBIB(5), NFKBIE(5), PLEKHG5(9), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF10B(8), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFSF10(3), TP73(5), TRAF1(7), TRAF2(8), TRAF3(12)	36193873	427	187	378	132	104	85	48	96	94	0	0.239	1.000	1.000
181	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	45	ACTA1(14), AGT(12), AKT1(11), CALM2(1), CALM3(1), CALR(2), CAMK1G(7), CAMK4(9), CREBBP(81), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(10), FGF2(5), FKBP1A(2), GATA4(4), GSK3B(17), HAND1(5), HAND2(2), HRAS(4), IGF1(6), LIF(1), MAP2K1(12), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MEF2C(15), MYH2(42), NFATC2(12), NFATC3(15), NFATC4(12), NPPA(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KB1(9), SYT1(14)	28827813	424	187	393	153	125	94	45	93	66	1	0.384	1.000	1.000
182	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(32), CARM1(3), CCND1(2), CREBBP(81), EP300(56), ERCC3(19), ESR1(21), GRIP1(15), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), MEF2C(15), NCOR2(44), NR0B1(11), NRIP1(18), PELP1(11), POLR2A(14), SRA1(3), TBP(2)	31101277	431	186	375	191	113	89	45	82	102	0	0.997	1.000	1.000
183	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	59	ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CHPT1(4), CRLS1(1), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), ESCO1(22), ESCO2(18), ETNK1(3), GPAM(5), GPD1(3), GPD1L(5), GPD2(11), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(34), MYST4(33), NAT6(2), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(14), SH3GLB1(6)	41793491	460	185	428	183	141	74	65	120	59	1	0.871	1.000	1.000
184	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	66	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1C1(2), AKR1C2(3), AKR1C3(2), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), CYP1A1(10), CYP1A2(11), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2F1(7), CYP2S1(8), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9)	37362907	438	185	398	123	110	83	47	124	73	1	0.0285	1.000	1.000
185	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(42), AR(26), ESR1(21), ESR2(8), HNF4A(12), NPM1(3), NR0B1(11), NR1D1(8), NR1D2(10), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(5), NR2C2(11), NR2E1(13), NR2F1(6), NR2F2(11), NR3C1(11), NR4A1(3), NR4A2(16), NR5A1(5), NR5A2(9), PGR(16), PPARA(7), PPARD(5), PPARG(4), RARA(6), RARB(20), RARG(10), ROR1(23), RORA(6), RORC(6), RXRA(8), RXRB(8), RXRG(11), THRA(6), THRB(14), VDR(4)	26843553	406	185	379	136	138	71	47	91	57	2	0.247	1.000	1.000
186	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	34	AKT1(11), ATF2(7), CDC42(3), DLD(4), DUSP10(6), DUSP4(6), GAB1(15), GCK(6), IL1R1(7), JUN(2), MAP2K5(6), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK10(18), MAPK7(6), MAPK8(17), MAPK9(13), MYEF2(14), NFATC3(15), NR2C2(11), PAPPA(39), SHC1(14), TRAF6(4), ZAK(12)	32319345	424	185	371	116	113	69	54	97	89	2	0.0503	1.000	1.000
187	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CHEK1(11), MYT1(25), YWHAH(5)	9066004	306	183	239	104	53	106	22	71	46	8	0.367	1.000	1.000
188	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	53	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AGK(7), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CEL(13), DAK(8), DGAT1(5), DGAT2(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), GK(5), GK2(16), GLA(7), GLB1(9), GPAM(5), LCT(46), LIPA(3), LIPC(6), LIPF(3), LIPG(4), LPL(12), MGLL(2), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	38380264	456	183	425	177	129	66	65	143	52	1	0.748	1.000	1.000
189	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATM(237), ATR(53), CDC25C(6), CHEK1(11), YWHAH(5)	10199994	312	183	233	111	43	106	23	67	62	11	0.636	1.000	1.000
190	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	88	ANK2(84), B3GALT4(4), CDR1(8), DGKI(22), FAU(2), IL6ST(15), MRPL19(4), PIGK(12), RPL10(3), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(6), RPL6(4), RPL7(4), RPL7A(1), RPL8(3), RPL9(4), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(2), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS4X(3), RPS5(2), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), RPS7(1), RPS9(3), RPSA(1), SLC36A2(6), TSPAN9(5), UBA52(3), UBB(3), UBC(7)	33919000	378	181	355	108	98	76	51	94	57	2	0.122	1.000	1.000
191	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(81), DAXX(18), HRAS(4), PAX3(26), PML(12), RARA(6), RB1(139), SIRT1(8), SP100(15), TNF(2), TNFRSF1A(4), TNFRSF1B(1)	11937104	316	180	243	121	73	113	23	52	47	8	0.572	1.000	1.000
192	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	40	CD28(5), CD3D(5), CSK(5), CTLA4(5), DAG1(10), DTYMK(1), EPHB2(16), GRAP2(7), ITK(26), ITPKA(3), ITPKB(15), LAT(3), LCK(9), LCP2(10), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLCG1(19), PTPRC(36), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), SOS1(16), SOS2(17), VAV1(24), ZAP70(12)	32595830	396	179	374	134	105	89	49	89	64	0	0.303	1.000	1.000
193	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	39	AKT1(11), AKT2(8), AKT3(8), CAB39(2), EIF4B(5), FIGF(6), HIF1A(16), IGF1(6), MAPK1(3), MAPK3(4), PDPK1(4), PGF(4), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R2(3), PIK3R3(7), PIK3R5(5), PRKAA1(9), PRKAA2(20), RHEB(5), RICTOR(27), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), STK11(38), TSC1(18), TSC2(17), ULK2(14), ULK3(3), VEGFA(5), VEGFC(15)	29798905	407	175	374	145	120	83	50	89	63	2	0.519	1.000	1.000
194	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	38	BCL2(2), CHUK(27), DAXX(18), EGF(8), ETS1(10), ETS2(5), FOS(5), HOXA7(4), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK1(3), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), NFKB1(11), NFKBIA(1), PPP2CA(3), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), RELA(10), RIPK1(7), SP1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	29381813	340	175	306	119	100	88	39	72	41	0	0.319	1.000	1.000
195	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHFR(1), DHX58(6), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), FPGS(4), GGH(2), IFIH1(22), MOV10L1(23), NUDT5(1), QDPR(2), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SKIV2L2(13), SMARCA2(22), SMARCA5(18), SPR(7)	42240555	478	174	432	156	149	83	53	106	85	2	0.327	1.000	1.000
196	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	44	ACCN1(14), ADCY4(14), ADCY6(13), ADCY8(34), CACNA1A(28), CACNA1B(40), GNAT3(4), GNB1(3), GNB3(6), GNG3(2), GRM4(15), ITPR3(44), KCNB1(22), PDE1A(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), SCNN1A(8), SCNN1B(8), SCNN1G(12), TAS1R1(13), TAS1R2(22), TAS2R1(5), TAS2R10(10), TAS2R13(9), TAS2R14(2), TAS2R16(7), TAS2R3(6), TAS2R38(7), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R43(3), TAS2R46(1), TAS2R5(4), TAS2R50(10), TAS2R60(4), TAS2R7(4), TAS2R8(9), TAS2R9(3), TRPM5(5)	32826317	431	173	429	158	159	53	44	101	73	1	0.697	1.000	1.000
197	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	111	ATP12A(35), ATP4A(20), ATP4B(3), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5L(2), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), COX10(6), COX15(8), COX17(1), COX4I1(5), COX4I2(4), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(6), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(3), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(8), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(4), NDUFC1(1), NDUFC2(2), NDUFS1(16), NDUFS2(6), NDUFS3(4), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(5), PPA1(3), PPA2(5), SDHA(14), SDHB(3), SDHD(4), TCIRG1(7), UQCRB(2), UQCRC1(4), UQCRC2(13), UQCRFS1(3), UQCRH(1)	37963328	433	172	398	129	142	89	52	83	67	0	0.0120	1.000	1.000
198	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), F10(5), F11(8), F12(5), F2(10), F2R(11), F5(37), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), PROC(3), PROS1(12), SERPINC1(8), SERPING1(7)	31265399	375	172	347	149	83	72	55	99	64	2	0.679	1.000	1.000
199	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(27), CREBBP(81), DUSP1(7), EP300(56), IKBKB(9), IL1B(5), IL8(6), MAP2K3(11), MAP2K6(5), MAP3K14(6), MAP3K7(9), MAPK14(8), MYD88(4), NFKB1(11), NFKBIA(1), NR3C1(11), RELA(10), TGFBR1(20), TGFBR2(26), TLR2(12), TNF(2)	20033236	327	172	281	114	87	98	34	63	44	1	0.294	1.000	1.000
200	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTG2(6), ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), CDC42(3), CFL1(2), CFL2(2), FLNA(31), FLNC(39), FSCN1(5), FSCN3(6), GDI1(1), GDI2(2), LIMK1(8), MYH2(42), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PFN2(4), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), VASP(4), WASF1(6), WASL(18)	30035145	406	171	373	137	120	63	49	89	80	5	0.286	1.000	1.000
201	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ENPP1(17), ENPP3(12), G6PC(5), GAA(14), GANAB(13), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), MGAM(26), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), SI(28), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UXS1(9)	40341344	392	171	375	118	112	71	49	83	76	1	0.123	1.000	1.000
202	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(2), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), HSD3B7(3), NSD1(29), OGDH(14), OGDHL(16), PIPOX(9), PLOD1(8), PLOD2(10), PLOD3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SETD1A(21), SETD7(9), SETDB1(19), SHMT1(7), SHMT2(5), SPCS1(3), SPCS3(2), SUV39H1(4), SUV39H2(7), TMLHE(6)	37622270	386	170	359	119	133	56	39	91	67	0	0.160	1.000	1.000
203	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	49	ALG2(8), BAK1(2), BTK(12), CAD(23), CASP10(7), CASP3(4), CASP8(20), CASP8AP2(30), CD7(6), CSNK1A1(3), DAXX(18), DEDD(3), DEDD2(1), DFFA(6), DIABLO(3), EPHB2(16), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(6), MAP3K1(21), MAP3K5(16), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PFN2(4), PTPN13(23), RALBP1(8), RIPK1(7), ROCK1(35), SMPD1(10), TPX2(10), TRAF2(8), TUFM(6)	40141860	438	170	411	137	104	84	44	123	77	6	0.341	1.000	1.000
204	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	43	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), CEL(13), DGAT1(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), GK(5), GLA(7), GLB1(9), LCT(46), LIPC(6), LIPF(3), LIPG(4), LPL(12), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	31169452	392	169	363	143	110	66	55	114	46	1	0.454	1.000	1.000
205	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3)	31281573	394	169	360	151	115	64	47	89	75	4	0.697	1.000	1.000
206	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	47	ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3)	31281573	394	169	360	151	115	64	47	89	75	4	0.697	1.000	1.000
207	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	46	ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(9), ACOX1(11), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP4A11(8), CYP4A22(13), DCI(4), ECHS1(4), EHHADH(15), GCDH(8), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), PECI(2)	32984795	377	166	348	117	101	67	61	97	51	0	0.0353	1.000	1.000
208	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	20	CPEB1(10), ERBB4(65), ETS1(10), ETS2(5), ETV6(11), ETV7(3), MAP2K1(12), MAPK1(3), MAPK3(4), NOTCH2(35), NOTCH3(31), NOTCH4(20), PIWIL1(31), PIWIL2(16), PIWIL3(15), PIWIL4(10), SOS1(16), SOS2(17), SPIRE1(6), SPIRE2(9)	24189263	329	165	304	98	91	53	52	83	50	0	0.121	1.000	1.000
209	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	66	CALR(2), CANX(5), CD4(4), CD74(3), CD8A(2), CD8B(4), CIITA(18), CREB1(3), CTSB(6), CTSL1(8), CTSS(4), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), HSP90AA1(9), HSP90AB1(4), HSPA5(5), IFI30(3), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(10), KIR2DL4(5), KIR2DS4(4), KIR3DL1(10), KIR3DL2(7), KIR3DL3(11), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LGMN(3), LTA(1), NFYA(5), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(15), RFXANK(1), RFXAP(5), TAP1(9), TAP2(16), TAPBP(6)	27307902	355	165	331	116	66	67	45	99	66	12	0.416	1.000	1.000
210	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	28	AKT1(11), AR(26), ASAH1(4), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(10), GNA11(8), GNA15(6), GNAI1(5), GNAQ(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), MAPK10(18), MAPK14(8), PHKA2(19), PIK3CD(11), PITX2(2), PTX3(3), SRC(3)	24661654	338	165	329	119	113	54	40	87	43	1	0.245	1.000	1.000
211	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(11), BCL2(2), IGF1R(22), MYC(5), POLR2A(14), PPP2CA(3), PRKCA(8), RB1(139), TEP1(29), TERF1(6), TERT(10), TNKS(11), XRCC5(13)	16774886	273	164	212	104	60	89	25	46	45	8	0.636	1.000	1.000
212	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), RB1(139), RBL1(21), TFDP1(10)	10864390	263	163	207	100	47	86	20	61	41	8	0.548	1.000	1.000
213	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(27), BAD(1), BCL2(2), BCL2A1(5), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CD40(7), CD40LG(10), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), IKBKE(9), LTA(1), NFKB1(11), NFKBIA(1), NGFR(5), NR3C1(11), NTRK1(17), PTPN13(23), RIPK1(7), SFRS2IP(3), TFG(8), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12), TRAF6(4)	28624864	303	162	276	144	66	78	30	67	62	0	0.999	1.000	1.000
214	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	29	AKT1(11), AKT2(8), AKT3(8), ASAH1(4), DAG1(10), DRD2(9), EPHB2(16), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PI3(3), PIK3CB(6), PITX2(2), PLCB1(23), PLCB3(15), PLCB4(23), RGS20(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT3(10), TERF2IP(4)	33333231	399	162	379	119	127	66	49	92	63	2	0.0628	1.000	1.000
215	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	57	A4GALT(6), ABO(7), B3GALNT1(6), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(5), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT6(10), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GBGT1(1), GCNT2(26), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGX(4), PIGZ(6), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(16), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10), UGCG(9)	30606997	365	161	334	122	113	65	28	96	62	1	0.536	1.000	1.000
216	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(8), ACAA1(7), ACAA2(4), ACADM(12), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), AOX1(15), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(4), ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HADHB(10), HIBADH(2), HIBCH(3), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), OXCT2(3), PCCA(17), PCCB(6)	29680255	312	158	286	81	94	51	39	66	61	1	0.0120	1.000	1.000
217	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	20	IMPA1(4), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MIOX(3), OCRL(21), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CB(6), PIK3CG(41), PLCB1(23), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28)	26270900	331	158	302	102	107	61	40	73	49	1	0.211	1.000	1.000
218	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ITPA(6), NME1(1), NT5C(1), NT5E(7), NT5M(3), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), RRM1(3), RRM2(5), TK1(2), TK2(3), TXNRD1(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UNG(3), UPB1(9), UPP1(5)	38761888	391	158	374	123	108	63	58	110	52	0	0.131	1.000	1.000
219	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	ABP1(4), AGMAT(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH4A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), GAMT(6), GATM(2), GLUD1(4), GOT1(7), GOT2(2), MAOA(7), MAOB(9), NOS1(31), NOS3(23), OAT(4), ODC1(8), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(6), RARS(9), SMS(4)	28972408	356	157	325	116	122	53	45	80	56	0	0.208	1.000	1.000
220	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(6), GTF2A1L(13), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2F1(7), GTF2F2(1), GTF2H1(6), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(19), TAF1(32), TAF10(1), TAF12(4), TAF13(3), TAF1L(66), TAF2(20), TAF4(11), TAF4B(11), TAF5(13), TAF5L(3), TAF6(9), TAF6L(5), TAF7(3), TAF7L(14), TAF9(3), TAF9B(1), TBPL1(3), TBPL2(2)	24723511	280	157	253	85	72	52	32	79	44	1	0.209	1.000	1.000
221	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	10	AXIN1(10), CREBBP(81), EP300(56), FZD1(9), GSK3B(17), HDAC1(5), LDB1(9), LEF1(9), PITX2(2), TRRAP(70)	16552447	268	156	233	101	81	78	34	34	40	1	0.304	1.000	1.000
222	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(4), AKT1(11), ASAH1(4), CAMP(1), CAV3(4), DAG1(10), DLG4(10), EPHB2(16), GNAI1(5), GNAQ(11), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(5), RYR1(70)	26282735	327	156	323	133	135	47	41	67	35	2	0.598	1.000	1.000
223	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(30), EEF1A2(8), EEF1B2(3), EEF1D(12), EEF1G(1), EEF2(7), EEF2K(11), EIF1AX(1), EIF2AK1(16), EIF2AK2(5), EIF2AK3(14), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF4A2(12), EIF4EBP2(4), EIF4G1(19), EIF4G3(19), EIF5(6), EIF5A(3), EIF5B(20), ETF1(13), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(23), PAIP1(7), SLC35A4(3)	29310599	313	156	268	82	71	72	29	70	71	0	0.0443	1.000	1.000
224	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	34	AGT(12), AGTR2(17), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDK5(3), F2(10), FYN(17), GNA11(8), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MAPT(11), MYLK(33), PLCG1(19), PRKCA(8), PTK2B(13), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), SYT1(14)	25840982	321	155	287	119	86	63	40	74	57	1	0.691	1.000	1.000
225	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	45	ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPS(6), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CLC(3), CPT1B(14), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), ETNK1(3), GPD1(3), GPD2(11), LCAT(4), LGALS13(5), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(7), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPAP2A(2), PPAP2B(2), PPAP2C(3)	29422770	336	155	315	135	126	42	46	78	44	0	0.816	1.000	1.000
226	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	60	ACSS1(7), ACSS2(10), ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), G6PC2(3), GALM(3), GAPDH(2), GAPDHS(3), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	37011433	385	155	359	141	130	58	40	103	54	0	0.539	1.000	1.000
227	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(8), ADC(3), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EARS2(3), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GFPT2(12), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), GMPS(16), GNPNAT1(1), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSR(5), GSS(9), NADSYN1(4), NAGK(7), PPAT(8), QARS(14)	27172490	303	155	281	83	85	59	37	85	37	0	0.0280	1.000	1.000
228	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	35	CALM2(1), CALM3(1), CD3D(5), CD3E(2), ELK1(4), FOS(5), FYN(17), HRAS(4), JUN(2), LAT(3), LCK(9), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), PTPN7(4), RAC1(2), RASA1(24), RELA(10), SHC1(14), SOS1(16), SYT1(14), VAV1(24), ZAP70(12)	27010267	328	155	295	107	108	66	28	62	63	1	0.254	1.000	1.000
229	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	32	ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), BCR(12), CAPN1(2), CAPNS1(4), CAPNS2(4), CAV1(1), CRKL(5), CSK(5), FYN(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MAPK8(17), PTK2(24), PXN(2), RAP1A(2), ROCK1(35), SHC1(14), SOS1(16), SRC(3), TLN1(23), VCL(10), ZYX(5)	27987052	312	154	288	118	90	49	40	74	53	6	0.740	1.000	1.000
230	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), DAG1(10), DGKA(8), ETFA(5), GCA(1), ITGA9(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAPK1(3), MAPK3(4), NR1I3(5), PAK1(11), PDE3A(21), PDE3B(10), PI3(3), PIK3C2G(21), PIK3CD(11), PLDN(1), PSME1(1), RIPK3(6), RPS4X(3), SGCB(7), VASP(4)	29292484	346	154	339	117	103	57	40	88	55	3	0.338	1.000	1.000
231	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(11), CREB1(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NFKB1(11), RB1(139), RELA(10), SP1(7)	10984766	248	153	191	79	51	80	22	55	32	8	0.138	1.000	1.000
232	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), ESCO1(22), ESCO2(18), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), PRDX6(5), SH3GLB1(6), TAT(16), TPO(36)	22992331	317	153	275	103	110	53	37	69	47	1	0.189	1.000	1.000
233	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), DBH(9), DCT(22), DDC(5), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HGD(6), HPD(7), MAOA(7), MAOB(9), PNMT(3), TAT(16), TPO(36), TYR(12)	20736047	272	153	238	100	87	52	33	69	31	0	0.363	1.000	1.000
234	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1D1(9), ARSD(9), ARSE(4), CARM1(3), CYP11B1(17), CYP11B2(7), CYP19A1(11), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), WBSCR22(2)	32604910	336	151	323	104	87	58	41	85	65	0	0.127	1.000	1.000
235	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(2), CREBBP(81), EP300(56), FYN(17), IL2RG(9), IL7(4), IL7R(13), JAK1(22), JAK3(31), LCK(9), NMI(4), PTK2B(13), STAT5A(10), STAT5B(20)	16681528	291	151	240	100	68	78	26	59	59	1	0.548	1.000	1.000
236	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(31), CDKN2A(9), MDM2(11), MYC(5), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), RAC1(2), RB1(139), TWIST1(3)	10046585	242	149	187	84	48	89	25	43	29	8	0.220	1.000	1.000
237	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	49	ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	31165984	339	149	313	119	114	58	35	89	43	0	0.336	1.000	1.000
238	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	49	ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	31165984	339	149	313	119	114	58	35	89	43	0	0.336	1.000	1.000
239	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	22	ARNT(9), EIF1(2), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), ELAVL1(5), FLT1(43), FLT4(18), HIF1A(16), HRAS(4), KDR(42), NOS3(23), PLCG1(19), PRKCA(8), PTK2(24), PXN(2), SHC1(14)	19535415	272	149	229	104	62	70	31	55	53	1	0.853	1.000	1.000
240	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	31	ABAT(8), ACACA(36), ACACB(40), ACADM(12), ACAT1(7), ACAT2(9), ACSS1(7), ACSS2(10), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), HIBCH(3), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SUCLA2(9), SUCLG1(3), SUCLG2(1)	26862918	311	148	289	68	96	37	47	75	56	0	0.000628	1.000	1.000
241	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(7), IFNG(3), IFNGR1(8), IFNGR2(5), IKBKB(9), LIN7A(7), NFKB1(11), NFKBIA(1), RB1(139), RELA(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), USH1C(15), WT1(32)	10090500	254	148	191	93	48	92	20	49	36	9	0.507	1.000	1.000
242	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	35	ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), AOX1(15), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), HIBADH(2), HMGCL(1), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), PCCA(17), PCCB(6), SDS(3)	24558262	296	148	270	71	86	48	39	70	52	1	0.00173	1.000	1.000
243	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	39	ACACA(36), ACACB(40), ACAT1(7), ACAT2(9), ACOT12(11), ACSS1(7), ACSS2(10), ACYP1(2), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PCK2(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4)	30926806	348	147	327	115	109	48	47	88	56	0	0.308	1.000	1.000
244	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	38	ABP1(4), ACY3(4), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(10), ASPA(8), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(12), HARS(6), HARS2(8), HDC(14), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), PRPS2(6), UROC1(10), WBSCR22(2)	24926198	279	146	266	90	84	49	37	73	36	0	0.136	1.000	1.000
245	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	40	ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG5(5), ALG6(5), ALG8(13), ALG9(8), B4GALT1(8), B4GALT2(7), B4GALT3(8), DAD1(3), DDOST(4), DHDDS(6), DPM1(3), FUT8(11), GANAB(13), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), RFT1(3), RPN1(4), RPN2(7), ST6GAL1(3), STT3B(11)	27274388	311	146	286	111	82	55	32	87	55	0	0.861	1.000	1.000
246	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	35	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCR(12), BLNK(2), BTK(12), CD19(10), CSK(5), DAG1(10), EPHB2(16), ITPKA(3), ITPKB(15), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PI3(3), PIK3CD(11), PLCG2(28), PPP1R13B(10), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24)	30184815	319	146	297	90	113	54	40	72	39	1	0.0103	1.000	1.000
247	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(5), AKT1(11), AKT2(8), AKT3(8), DAG1(10), GNAQ(11), IKBKG(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PIK3CB(6), PITX2(2), PLD1(19), PLD2(10), PLD3(7), VN1R1(7)	28429292	314	146	306	103	103	60	39	70	41	1	0.187	1.000	1.000
248	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	31	BLNK(2), BTK(12), CALM2(1), CALM3(1), CD79A(6), CD79B(3), ELK1(4), FOS(5), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK14(8), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), RAC1(2), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24)	23999748	282	144	259	92	85	58	31	61	46	1	0.283	1.000	1.000
249	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(4), AGXT(8), AGXT2(9), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), ATP6V0C(1), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CPT1B(14), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), MAOA(7), MAOB(9), PEMT(2), PISD(8), PLCG1(19), PLCG2(28), PSPH(2), SARDH(17), SARS(6), SHMT1(7), SHMT2(5), TARS(10)	26864437	304	144	279	106	117	43	38	57	49	0	0.428	1.000	1.000
250	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	26	ABAT(8), ABP1(4), ACADL(6), ACADM(12), ACADSB(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), MLYCD(4), SDS(3), SMS(4), UPB1(9)	19388375	284	143	264	78	85	40	43	79	37	0	0.00878	1.000	1.000
251	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(8), F12(5), F13B(12), F2(10), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), LPA(30), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10), SERPINF2(4), VWF(36)	24266775	325	143	295	129	81	61	48	83	49	3	0.823	1.000	1.000
252	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	25	DPM2(1), ELK1(4), GNB1(3), GNGT1(1), HRAS(4), IGF1R(22), ITGB1(13), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MYC(5), NGFR(5), PDGFRA(64), PPP2CA(3), PTPRR(16), RPS6KA1(9), RPS6KA5(13), SHC1(14), SOS1(16), SRC(3), STAT3(10)	18254428	243	143	218	92	57	60	34	54	34	4	0.610	1.000	1.000
253	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(35), ATP4B(3), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ATP7A(13), ATP7B(16), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3), PPA2(5), SDHA(14), SDHB(3), SHMT1(7), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1)	26255858	279	143	256	92	87	51	36	59	46	0	0.176	1.000	1.000
254	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(11), AKT2(8), AKT3(8), ARHGEF11(24), BCL2(2), CDC42(3), DLG4(10), GNA13(3), IKBKG(2), LPA(30), MAP3K1(21), MAP3K5(16), MAPK8(17), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PI3(3), PIK3CB(6), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RDX(16), ROCK1(35), ROCK2(20), SERPINA4(10), SRF(4)	32302569	363	143	338	112	108	54	33	99	64	5	0.387	1.000	1.000
255	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	AKT1(11), ATF1(6), CDC42(3), CREB1(3), CREB3(6), CREB5(8), DUSP1(7), DUSP10(6), EEF2K(11), ELK1(4), IL1R1(7), MAP2K3(11), MAP2K6(5), MAP3K10(11), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MKNK1(4), MKNK2(7), MYEF2(14), NFKB1(11), NR2C2(11), SRF(4), TRAF6(4)	21860849	265	143	236	73	69	46	40	60	49	1	0.0445	1.000	1.000
256	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	CREBBP(81), EP300(56), MAP2K1(12), MAP3K7(9), MAPK3(4), SKIL(9), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26)	12846906	231	143	195	91	67	68	26	36	34	0	0.574	1.000	1.000
257	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	31	ADCY1(27), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(5), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RPS6KA3(16), SYT1(14)	20208502	237	142	216	88	84	57	20	42	34	0	0.407	1.000	1.000
258	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(8), AGXT2(9), AKR1B10(3), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), GNMT(3), HSD3B7(3), MAOA(7), MAOB(9), PEMT(2), PHGDH(3), PIPOX(9), PISD(8), PSAT1(7), PSPH(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SARDH(17), SARS(6), SARS2(4), SDS(3), SHMT1(7), SHMT2(5), TARS(10), TARS2(10)	29237069	303	142	286	109	110	39	39	72	43	0	0.511	1.000	1.000
259	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	AKR1C3(2), ALOX12(4), ALOX12B(6), ALOX15(5), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP2U1(5), CYP4A11(8), CYP4A22(13), CYP4F2(12), CYP4F3(11), DHRS4(1), EPHX2(5), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	26093176	276	142	259	97	92	39	35	74	35	1	0.507	1.000	1.000
260	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	28	ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), DRD1(9), DRD2(9), DRD3(6), DRD5(14), HRH1(4), HRH2(16), HTR1A(17), HTR1B(13), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13)	15058320	273	142	250	102	115	44	36	47	31	0	0.154	1.000	1.000
261	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	21	CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PDGFA(2), PDGFRA(64), PLCG1(19), PRKCA(8), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10)	19750058	286	142	256	89	70	61	29	74	48	4	0.313	1.000	1.000
262	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(2), CHN1(6), LIMK1(8), MAP3K1(21), MYL2(2), MYLK(33), NCF2(10), PAK1(11), PDGFRA(64), PLD1(19), RAC1(2), RALBP1(8), RPS6KB1(9), TRIO(40), VAV1(24), WASF1(6)	20085355	275	142	257	94	68	59	37	71	36	4	0.296	1.000	1.000
263	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), HRAS(4), MAPK1(3), MAPK3(4), NFKB1(11), NFKBIA(1), PAK1(11), RAC1(2), RB1(139), RELA(10), TFDP1(10)	10258741	234	142	178	89	44	79	21	46	36	8	0.666	1.000	1.000
264	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	30	BTK(12), CALM2(1), CALM3(1), ELK1(4), FCER1A(6), FOS(5), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PAK2(15), PLA2G4A(16), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24)	23763622	293	141	268	86	83	63	32	63	51	1	0.0958	1.000	1.000
265	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(28), GABBR1(20), GPRC5A(5), GPRC5B(4), GPRC5C(10), GPRC5D(3), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM7(36), GRM8(29)	13402320	257	141	223	103	104	34	32	53	34	0	0.630	1.000	1.000
266	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	43	AACS(9), AADAC(7), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ACSM1(10), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH7A1(8), ALDH9A1(4), BDH1(4), BDH2(2), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADH(2), HADHA(12), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), HSD3B7(3), ILVBL(9), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(8), PDHA2(17), PDHB(3), PLA1A(10), PPME1(2), PRDX6(5), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	26488056	298	141	273	99	100	49	37	74	38	0	0.150	1.000	1.000
267	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	28	ACTR2(2), ACTR3(5), ARHGAP1(3), ARHGAP4(7), ARHGAP6(11), ARHGEF1(15), ARHGEF11(24), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), BAIAP2(7), CFL1(2), DIAPH1(7), GSN(4), LIMK1(8), MYL2(2), MYLK(33), OPHN1(11), PIP5K1A(7), PIP5K1B(4), ROCK1(35), SRC(3), TLN1(23), VCL(10)	28260981	252	141	233	89	78	35	27	61	46	5	0.727	1.000	1.000
268	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(6), CHUK(27), ELK1(4), FOS(5), IKBKB(9), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), PPARA(7), RELA(10), TIRAP(5), TLR10(14), TLR2(12), TLR3(15), TLR4(18), TLR6(14), TLR7(18), TLR9(16), TOLLIP(5), TRAF6(4)	24124288	296	141	283	79	76	57	27	86	48	2	0.0458	1.000	1.000
269	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	38	APAF1(27), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), FADD(1), FAS(9), FASLG(3), GZMB(5), IKBKG(2), JUN(2), MAP3K1(21), MAP3K14(6), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), PARP1(17), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(3), TRAF1(7), TRAF2(8)	23512541	266	140	237	83	65	54	32	54	61	0	0.219	1.000	1.000
270	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	37	AARS(10), AARS2(13), CARS(11), CARS2(6), DARS(5), DARS2(8), EARS2(3), EPRS(27), FARS2(7), FARSA(6), FARSB(12), GARS(8), HARS(6), HARS2(8), IARS(10), IARS2(19), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), MTFMT(1), NARS(5), NARS2(11), PARS2(2), QARS(14), RARS(9), SARS(6), SARS2(4), TARS(10), TARS2(10), VARS(7), VARS2(9), WARS(4), WARS2(7), YARS(4), YARS2(7)	35658967	318	140	311	83	103	43	41	83	48	0	0.0391	1.000	1.000
271	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(3), B4GALT1(8), B4GALT2(7), G6PC(5), G6PC2(3), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANC(9), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), HSD3B7(3), LALBA(2), LCT(46), MGAM(26), PFKL(7), PFKM(5), PFKP(16), PGM1(10), PGM3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), UGP2(12)	24841549	283	139	272	100	103	43	31	77	29	0	0.324	1.000	1.000
272	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	38	CDC6(10), CDK2(5), DIAPH2(28), MCM10(12), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), PRIM1(5), RFC1(25), RFC2(3), RFC4(8), RFC5(8), RPA1(12), RPA2(1), RPA4(6), UBA52(3), UBB(3), UBC(7)	32567229	315	138	284	98	67	60	41	86	60	1	0.322	1.000	1.000
273	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	34	CALM2(1), CALM3(1), CAMK1G(7), ELK1(4), FPR1(8), GNA15(6), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NCF1(4), NCF2(10), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PAK1(11), PIK3C2G(21), PLCB1(23), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAC1(2), RELA(10), SYT1(14)	23547750	271	138	256	99	86	46	30	67	41	1	0.550	1.000	1.000
274	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	25	ACVR1(9), ATF2(7), AXIN1(10), BMP10(15), BMP2(9), BMP4(6), BMP5(9), BMP7(15), CHRD(16), FZD1(9), GATA4(4), GSK3B(17), MAP3K7(9), MEF2C(15), MYL2(2), NPPA(1), NPPB(5), RFC1(25), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17)	15907711	260	137	242	83	96	43	28	59	33	1	0.107	1.000	1.000
275	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	18	ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12)	13475126	227	137	205	82	64	62	23	41	35	2	0.378	1.000	1.000
276	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	18	ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12)	13475126	227	137	205	82	64	62	23	41	35	2	0.378	1.000	1.000
277	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(27), AKT1(11), ASAH1(4), GNAI1(5), GNB1(3), GNGT1(1), ITGAV(21), ITGB3(16), MAPK1(3), MAPK3(4), PDGFA(2), PDGFRA(64), PLCB1(23), PRKCA(8), PTK2(24), RAC1(2), SMPD1(10), SMPD2(3), SPHK1(3), SRC(3)	16231580	237	137	211	92	58	60	30	59	26	4	0.644	1.000	1.000
278	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ACTG1(6), ACTG2(6), ADCY3(11), ADCY9(22), AK1(2), ARF1(1), ARF4(5), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ERO1L(4), PDIA4(9), PLCG1(19), PLCG2(28), PRKCA(8), SEC61A1(10), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(18)	24099621	270	137	234	97	93	60	30	50	37	0	0.385	1.000	1.000
279	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(8), B4GALT2(7), FBP2(5), G6PC(5), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANAB(13), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), LALBA(2), LCT(46), MGAM(26), PFKM(5), PFKP(16), PGM1(10), PGM3(7)	21134447	248	136	239	93	90	44	27	61	26	0	0.538	1.000	1.000
280	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	34	ACACA(36), ACAT1(7), ACAT2(9), ACYP1(2), ADH5(7), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4)	23890658	289	136	267	101	89	46	37	74	43	0	0.463	1.000	1.000
281	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	25	AKT1(11), AKT2(8), AKT3(8), ANKRD6(12), AXIN1(10), AXIN2(27), CER1(6), CSNK1A1(3), DACT1(19), DKK1(9), DKK3(9), DKK4(8), FSTL1(10), GSK3A(6), GSK3B(17), LRP1(53), MVP(10), NKD1(6), PIN1(2), PSEN1(4), PTPRA(6), SENP2(4), SFRP1(3), TSHB(2), WIF1(5)	20523244	258	136	242	82	92	37	29	50	47	3	0.238	1.000	1.000
282	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(3), CREBBP(81), EP300(56), NCOA3(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RARA(6), RXRA(8)	14144361	213	135	187	87	52	56	28	41	36	0	0.754	1.000	1.000
283	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(10), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(8), ADSSL1(6), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), ASRGL1(1), ASS1(5), CAD(23), CRAT(11), DARS(5), DARS2(8), DDO(6), DLAT(10), DLD(4), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), NARS2(11), PC(16), PDHA1(8), PDHA2(17), PDHB(3)	25476532	280	135	263	109	96	39	41	64	40	0	0.747	1.000	1.000
284	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(12), ALAS2(12), BLVRA(2), BLVRB(2), COX10(6), COX15(8), CP(24), CPOX(4), EARS2(3), EPRS(27), FECH(4), FTH1(1), FTMT(8), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), MMAB(2), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UROD(3), UROS(5)	28229195	298	135	269	72	67	55	39	80	57	0	0.0271	1.000	1.000
285	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	30	AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ATP6V0C(1), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADHA(12), PLOD1(8), PLOD2(10), PLOD3(7), SDS(3), SHMT1(7), SHMT2(5), TMLHE(6)	23099018	267	135	244	70	79	46	36	63	43	0	0.00585	1.000	1.000
286	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(27), CREBBP(81), EP300(56), FADD(1), HDAC3(3), IKBKB(9), IKBKG(2), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	15327977	219	135	188	81	59	66	23	36	35	0	0.463	1.000	1.000
287	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	22	ATF2(7), BCR(12), BLNK(2), ELK1(4), FOS(5), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8IP3(12), PAPPA(39), RAC1(2), RPS6KA1(9), RPS6KA3(16), SHC1(14), SOS1(16), SYK(8), VAV1(24), VAV3(30)	19547987	259	134	238	64	78	49	33	65	33	1	0.00470	1.000	1.000
288	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), PON1(12)	19550871	255	133	246	77	98	42	22	63	28	2	0.0872	1.000	1.000
289	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	35	ATF2(7), CDC42(3), CREB1(3), DAXX(18), DDIT3(5), ELK1(4), HRAS(4), HSPB2(3), MAP2K6(5), MAP3K1(21), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MYC(5), PLA2G4A(16), RAC1(2), RIPK1(7), RPS6KA5(13), SHC1(14), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8)	23900243	279	133	257	87	84	58	28	62	46	1	0.276	1.000	1.000
290	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	24	ABAT(8), ABP1(4), ACADM(12), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HIBCH(3), MLYCD(4), SMS(4), SRM(1), UPB1(9)	17831348	251	132	232	76	74	35	39	69	34	0	0.0736	1.000	1.000
291	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	17	CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), IL6(7), IL6R(8), IL6ST(15), JAK1(22), JAK3(31), JUN(2), MAP2K1(12), MAPK3(4), PTPN11(41), SHC1(14), SOS1(16), SRF(4), STAT3(10)	13222852	206	132	161	61	47	54	27	42	34	2	0.184	1.000	1.000
292	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(5), CDKN1B(6), CKS1B(2), CUL1(17), NEDD8(1), RB1(139), RBX1(1), SKP2(3), TFDP1(10), UBE2M(2)	6024134	192	132	139	73	31	70	10	38	35	8	0.660	1.000	1.000
293	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	29	ABAT(8), ACACA(36), ACADL(6), ACADM(12), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SDS(3), SUCLA2(9), SUCLG1(3), SUCLG2(1)	22237433	275	132	253	61	84	36	40	66	49	0	0.00176	1.000	1.000
294	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(18), CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), SKP2(3), TFDP1(10)	6148005	200	132	145	78	34	73	10	44	31	8	0.619	1.000	1.000
295	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(27), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), GAS2(4), LMNA(1), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), SPTAN1(30), TNFRSF10A(8), TNFRSF10B(8), TNFRSF25(2), TNFSF10(3), TNFSF12(2), TRAF2(8)	22591935	240	131	209	79	57	52	27	54	49	1	0.485	1.000	1.000
296	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ALDH4A1(8), ARG1(2), ARG2(6), ASL(5), ASS1(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), EPRS(27), GAMT(6), GATM(2), GLUD1(4), GLUD2(22), GOT1(7), GOT2(2), LAP3(4), NOS1(31), NOS3(23), OAT(4), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(2), PRODH(5), RARS(9)	23050422	269	131	249	85	89	38	38	64	40	0	0.220	1.000	1.000
297	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CYP2C19(12), CYP2C9(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), HADHA(12), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3)	20365936	269	131	240	81	69	55	35	67	42	1	0.165	1.000	1.000
298	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), NOS1(31), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), SYT1(14)	16989570	238	131	222	100	85	43	22	51	36	1	0.781	1.000	1.000
299	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	29	AGT(12), AGTR1(14), ATF2(7), CALM2(1), CALM3(1), ELK1(4), GNAQ(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), MEF2A(7), MEF2C(15), MEF2D(3), PAK1(11), PRKCA(8), PTK2(24), PTK2B(13), RAC1(2), SHC1(14), SOS1(16), SRC(3), SYT1(14)	19590708	246	130	228	83	51	52	24	71	47	1	0.578	1.000	1.000
300	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	27	ATF1(6), BAD(1), CREB1(3), CREB3(6), CREB5(8), DUSP4(6), DUSP6(7), DUSP9(9), EEF2K(11), MAP2K1(12), MAP2K2(3), MAP3K8(4), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MOS(10), NFKB1(11), RAP1A(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), SHC1(14), SOS1(16), SOS2(17), TRAF3(12)	18988327	226	130	209	71	63	46	30	45	41	1	0.162	1.000	1.000
301	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(8), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), GMPS(16), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSS(9), NADSYN1(4), PPAT(8), QARS(14)	22869210	250	129	228	64	65	53	31	70	31	0	0.0209	1.000	1.000
302	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	17	CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), INSR(21), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PTPN11(41), RASA1(24), SHC1(14), SLC2A4(8), SOS1(16), SRF(4)	13163001	204	129	174	67	49	49	25	49	31	1	0.331	1.000	1.000
303	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	18	AXIN1(10), BTRC(11), CCND1(2), CREBBP(81), CSNK1A1(3), CSNK1D(15), CSNK2A1(7), CTBP1(5), FZD1(9), GSK3B(17), HDAC1(5), MAP3K7(9), MYC(5), NLK(12), PPARD(5), PPP2CA(3), TLE1(7), WIF1(5)	13429103	211	129	191	80	57	47	35	38	33	1	0.461	1.000	1.000
304	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(15), POLA2(6), POLB(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLG(9), POLG2(4), POLH(16), POLK(11), POLL(2), POLM(12), POLQ(42), PRIM1(5), PRIM2(3), REV1(16), REV3L(45), RFC5(8)	27921628	285	128	260	87	65	42	38	81	57	2	0.457	1.000	1.000
305	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	16	CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), IGF1(6), IGF1R(22), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PTPN11(41), RASA1(24), SHC1(14), SOS1(16), SRF(4)	12683249	203	128	172	65	50	49	22	47	34	1	0.297	1.000	1.000
306	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	21	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), GSK3A(6), GSK3B(17), IL4R(6), IRS1(21), JAK1(22), JAK3(31), MAP4K1(7), MAPK1(3), MAPK3(4), PDK1(7), PIK3CD(11), PPP1R13B(10), SHC1(14), SOS1(16), SOS2(17), STAT6(4)	19545551	226	128	200	63	62	48	22	48	44	2	0.134	1.000	1.000
307	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	36	ACAA1(7), ACAA2(4), ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1B10(3), AKR1D1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), HSD3B7(3), LIPA(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SLC27A5(9), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2)	20508223	237	127	222	71	61	42	36	66	31	1	0.0977	1.000	1.000
308	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	41	ALDOA(2), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GAPDHS(3), GCK(6), GOT1(7), GOT2(2), GPI(6), HK1(13), HK2(7), HK3(22), LDHAL6B(7), LDHB(8), LDHC(4), MDH1(8), MDH2(3), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PKLR(12), PKM2(4), TNFAIP1(4), TPI1(3)	27107720	265	126	248	118	110	35	25	60	35	0	0.936	1.000	1.000
309	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	24	AKT1(11), CABIN1(24), CALM2(1), CALM3(1), CAMK1G(7), HDAC5(14), IGF1(6), IGF1R(22), INSR(21), MAP2K6(5), MAPK14(8), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYT1(14), YWHAH(5)	18427639	205	126	193	89	65	46	23	43	28	0	0.834	1.000	1.000
310	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(4), ACY1(6), ADC(3), AGMAT(7), ALDH18A1(8), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), ASS1(5), CPS1(39), GATM(2), MAOA(7), MAOB(9), NAGS(6), ODC1(8), OTC(17), SAT1(5), SAT2(2), SMS(4), SRM(1)	19619750	232	126	210	70	71	43	29	58	31	0	0.111	1.000	1.000
311	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM2(1), CALM3(1), CHUK(27), EGR2(16), EGR3(6), GNAQ(11), MAP3K1(21), MYC(5), NFATC2(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), SYT1(14), VIP(3), VIPR2(11)	17855655	227	126	205	73	70	50	24	44	39	0	0.182	1.000	1.000
312	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(15), AGT(12), AGTR1(14), AGTR2(17), CMA1(1), COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), REN(10)	18109524	216	125	205	72	54	30	29	60	43	0	0.100	1.000	1.000
313	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(12), CALCRL(9), CD97(12), CRHR1(6), CRHR2(6), ELTD1(14), EMR1(17), EMR2(11), GHRHR(2), GIPR(1), GLP1R(11), GLP2R(10), GPR64(19), LPHN1(20), LPHN2(30), LPHN3(30), SCTR(6), VIPR1(7), VIPR2(11)	18379554	239	125	235	99	79	37	20	74	29	0	0.764	1.000	1.000
314	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(81), EP300(56), LPL(12), NCOA1(15), NCOA2(23), PPARG(4), RXRA(8)	12259823	199	125	178	83	50	56	28	37	28	0	0.735	1.000	1.000
315	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(5), NFYB(2), NFYC(10), RB1(139), SP1(7), SP3(13)	4757427	176	125	123	59	23	74	10	37	24	8	0.121	1.000	1.000
316	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), P4HB(6), SLC23A1(10), SLC23A2(18), SLC2A1(7), SLC2A3(13)	17893323	201	125	188	77	52	26	31	51	41	0	0.268	1.000	1.000
317	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	26	AACS(9), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(8), PDHA2(17), PDHB(3), SDHB(3), SDS(3)	17310938	230	124	208	67	70	39	32	59	30	0	0.0391	1.000	1.000
318	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TAT(16), TPO(36)	14444897	203	124	177	62	84	28	25	38	28	0	0.0672	1.000	1.000
319	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	23	AKT1(11), AKT2(8), AKT3(8), CISH(2), IARS(10), IL13RA1(6), IL2RG(9), IL4(5), IL4R(6), INPP5D(10), JAK1(22), JAK3(31), PI3(3), PPP1R13B(10), RPS6KB1(9), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT6(4), TYK2(5)	21234277	219	124	195	62	56	40	23	51	47	2	0.218	1.000	1.000
320	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), TFDP1(10)	4739779	179	123	126	66	28	68	9	37	29	8	0.497	1.000	1.000
321	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	28	B4GALT5(5), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GCNT1(9), GCNT3(6), GCNT4(14), OGT(10), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(6)	21606286	249	123	238	96	76	40	34	66	33	0	0.857	1.000	1.000
322	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(25), C5(25), C6(27), C7(11), ICAM1(4), IL1A(1), IL6(7), IL8(6), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELP(15), TNF(2), VCAM1(15)	16334425	210	123	200	73	69	29	21	50	40	1	0.343	1.000	1.000
323	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), DAG1(10), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFAT5(6), PDE6A(14), PDE6B(11), PDE6C(12), PDE6D(2), SLC6A13(10), TF(21)	23328549	267	123	265	89	83	48	29	61	45	1	0.193	1.000	1.000
324	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(7), ACAT2(9), ACOT11(9), ACYP1(2), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), FN3K(1), GCDH(8), HADHA(12), ITGB1BP3(1), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3)	17500620	214	122	190	71	53	43	28	51	38	1	0.407	1.000	1.000
325	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(27), IFNA1(8), IFNB1(6), IKBKB(9), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL1RN(7), IL6(7), IRAK1(6), IRAK2(11), IRAK3(11), JUN(2), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2), TOLLIP(5), TRAF6(4)	19825512	242	122	224	68	76	43	25	64	34	0	0.0748	1.000	1.000
326	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	18	DIAPH1(7), FYN(17), GSN(4), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PTK2(24), PXN(2), ROCK1(35), SHC1(14), SRC(3), TLN1(23)	20592296	212	121	186	76	51	30	31	49	45	6	0.728	1.000	1.000
327	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(15), AGT(12), AGTR1(14), AGTR2(17), ANPEP(19), CMA1(1), CPA3(5), CTSA(6), CTSG(5), ENPEP(24), LNPEP(23), MAS1(3), MME(27), NLN(13), REN(10), THOP1(6)	14399905	214	121	194	54	52	38	26	60	38	0	0.0172	1.000	1.000
328	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(81), EP300(56), ESR1(21), MAPK1(3), MAPK3(4), PELP1(11), SRC(3)	10143037	179	121	157	75	46	47	21	34	31	0	0.809	1.000	1.000
329	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(2), ALOX12(4), ALOX15(5), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(11), EPX(14), LPO(10), LTA4H(2), MPO(17), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13), TPO(36)	18151964	216	121	203	73	93	28	26	42	27	0	0.212	1.000	1.000
330	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	27	DUSP1(7), GORASP1(13), IKBKG(2), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK5(7), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CD(11), SYT1(14), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4)	16320083	210	120	187	65	64	50	21	45	30	0	0.137	1.000	1.000
331	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	21	ABP1(4), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), AOC2(12), AOC3(10), ASPA(8), CNDP1(7), DDC(5), HAL(12), HARS(6), HDC(14), HNMT(11), MAOA(7), MAOB(9), PRPS2(6)	15370669	200	119	185	53	63	34	26	55	22	0	0.0148	1.000	1.000
332	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	20	CSNK2A1(7), ELK1(4), FOS(5), HRAS(4), IL2(5), IL2RA(6), IL2RB(5), IL2RG(9), JAK1(22), JAK3(31), JUN(2), LCK(9), MAP2K1(12), MAPK3(4), MAPK8(17), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8)	14560350	210	119	179	56	49	44	21	44	50	2	0.188	1.000	1.000
333	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	25	ACAA1(7), ACAA2(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AKR1D1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), SOAT2(4), SRD5A1(2), SRD5A2(2)	14865733	199	118	185	49	49	38	29	55	27	1	0.00984	1.000	1.000
334	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	37	ARNTL(14), AZIN1(3), BTG1(2), CBX3(7), CRY1(17), CRY2(5), DNAJA1(5), EIF4G2(16), ETV6(11), GFRA1(17), GSTM3(6), GSTP1(1), HERPUD1(3), HSPA8(13), IDI1(4), KLF9(1), MYF6(7), NCKAP1(17), NCOA4(9), NR1D2(10), PER1(13), PER2(9), PIGF(1), PPP1R3C(6), PPP2CB(4), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(8), TUBB3(10), UCP3(3), UGP2(12), VAPA(2), ZFR(21)	23709984	262	118	232	75	75	40	23	76	46	2	0.216	1.000	1.000
335	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(14), EPHA4(26), EPHB1(38), FYN(17), ITGA1(12), ITGB1(13), L1CAM(17), LYN(13), RAP1B(2), SELP(15)	10545769	167	118	153	56	52	34	31	31	18	1	0.135	1.000	1.000
336	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(12), ACO1(12), ACO2(7), CLYBL(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), OGDHL(16), PC(16), PCK1(6), PCK2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1)	19904306	187	118	175	68	61	25	27	49	25	0	0.506	1.000	1.000
337	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(6), AKR1B10(3), ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), FUK(9), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), HSD3B7(3), KHK(4), LHPP(6), MPI(4), MTMR1(13), MTMR2(8), MTMR6(11), PFKFB1(14), PFKFB2(5), PFKFB3(3), PFKFB4(5), PFKL(7), PFKM(5), PFKP(16), PGM2(4), PHPT1(2), PMM1(5), PMM2(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SORD(2), TPI1(3), TSTA3(1)	24455756	236	118	222	93	95	31	25	54	31	0	0.680	1.000	1.000
338	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(3), ENPP7(3), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(6), SGMS2(8), SGPP1(8), SGPP2(6), SMPD1(10), SMPD2(3), SMPD3(4), SMPD4(9), SPHK1(3), SPHK2(5), SPTLC1(12), SPTLC2(9), UGCG(9), UGT8(12)	21682977	235	118	223	87	72	41	34	53	34	1	0.443	1.000	1.000
339	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	25	BCAR1(6), CALM2(1), CALM3(1), CRKL(5), GNAQ(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), PAK1(11), PLCG1(19), PRKCA(8), PTK2B(13), RAC1(2), SHC1(14), SOS1(16), SRC(3), SYT1(14)	17281963	209	118	190	77	46	44	22	63	33	1	0.821	1.000	1.000
340	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6)	16773466	208	117	185	76	44	50	26	57	30	1	0.632	1.000	1.000
341	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	26	AGA(7), ARSB(10), FUCA1(7), FUCA2(5), GALNS(6), GBA(4), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NAGLU(6), NEU1(6), NEU2(6), NEU3(2), SPAM1(13)	21117860	237	116	219	83	77	52	22	57	29	0	0.374	1.000	1.000
342	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	20	CSNK2A1(7), EGF(8), ELK1(4), FOS(5), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PLCG1(19), PRKCA(8), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10)	19727722	228	115	208	68	63	40	23	57	43	2	0.328	1.000	1.000
343	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), BTRC(11), CDC16(6), CDC20(3), CDC23(12), CDC26(1), CDC27(21), CUL1(17), CUL2(15), CUL3(8), FBXW11(13), FZR1(4), ITCH(7), RBX1(1), SKP1(2), SKP2(3), SMURF1(9), SMURF2(7), TCEB1(1), TCEB2(1), UBA1(10), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(4), UBE2E2(4), UBE2E3(1), WWP1(21), WWP2(9)	26788878	242	115	226	84	73	34	32	61	40	2	0.570	1.000	1.000
344	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(11), ADRBK2(11), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CLCA1(14), CLCA2(11), CLCA4(15), CNGA3(17), CNGA4(14), CNGB1(15), GNAL(5), GUCA1A(3), GUCA1B(4), GUCA1C(3), PDC(4), PDE1C(19), PRKACA(2), PRKACB(5), PRKACG(9), PRKG1(18), PRKG2(12), PRKX(3)	21422132	228	115	218	107	64	34	31	64	35	0	0.978	1.000	1.000
345	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	27	AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CFLAR(3), CRKL(5), FOS(5), HRAS(4), IL2RA(6), IL2RB(5), IL2RG(9), IRS1(21), JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), MYC(5), NMI(4), PPIA(1), PTPN6(4), RPS6KB1(9), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8)	18470104	224	115	190	66	54	37	31	43	57	2	0.341	1.000	1.000
346	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(2), DLAT(10), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), PC(16), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PDK1(7), PDK2(9), PDK3(6), PDK4(6), PDP2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1)	19541091	203	115	186	81	64	33	26	51	29	0	0.761	1.000	1.000
347	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(14), CAPN1(2), CAPN2(10), CAPNS1(4), CAPNS2(4), CXCR3(5), EGF(8), HRAS(4), ITGA1(12), ITGB1(13), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTK2(24), PXN(2), TLN1(23)	20833582	202	115	196	79	54	43	33	42	29	1	0.605	1.000	1.000
348	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(27), FADD(1), IKBKB(9), IKBKG(2), IL1A(1), IL1R1(7), IRAK1(6), MAP3K1(21), MAP3K14(6), MAP3K7(9), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TLR4(18), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	16109182	193	115	178	62	46	55	18	44	30	0	0.253	1.000	1.000
349	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), LTA(1), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNFAIP3(42), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12)	15452709	195	115	173	64	52	55	20	34	34	0	0.206	1.000	1.000
350	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(16), DDX20(7), E2F4(2), ETS1(10), ETS2(5), ETV3(5), FOS(5), HDAC2(8), HDAC5(14), HRAS(4), JUN(2), NCOR2(44), RBL1(21), RBL2(24), SIN3A(28), SIN3B(10)	17145408	210	114	183	80	55	41	20	42	52	0	0.872	1.000	1.000
351	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(24), CALM2(1), CALM3(1), CAPN2(10), CAPNS1(4), CAPNS2(4), EP300(56), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SYT1(14)	15300958	173	114	153	73	50	35	22	32	34	0	0.825	1.000	1.000
352	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(7), CDK7(3), ERCC3(19), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2F2(1), GTF2H1(6), GTF2H4(3), ILK(3), MNAT1(4), POLR1A(15), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3B(14), POLR3D(5), POLR3E(13), POLR3H(2), POLR3K(2), TAF12(4), TAF13(3), TAF5(13), TAF6(9), TAF7(3), TAF9(3), TBP(2)	23929971	205	114	194	77	53	36	28	49	39	0	0.782	1.000	1.000
353	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BIRC2(7), BIRC3(18), CASP3(4), CASP8(20), CFLAR(3), FADD(1), IKBKG(2), JUN(2), MAP3K3(8), MAP3K7(9), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NR2C2(11), RALBP1(8), RIPK1(7), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	16227029	185	114	163	61	43	51	16	37	38	0	0.397	1.000	1.000
354	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(10), ABAT(8), ADSL(13), ADSS(8), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), CAD(23), CRAT(11), DARS(5), DDO(6), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), PC(16)	17503229	190	112	176	73	64	24	30	47	25	0	0.674	1.000	1.000
355	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(10), DYRK1B(14), GLI2(28), GLI3(44), GSK3B(17), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SHH(3), SMO(13), SUFU(5)	10475187	169	112	154	71	60	38	14	30	27	0	0.691	1.000	1.000
356	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(13), ITGB3(16), PTK2(24), PXN(2), RAC1(2), SPTAN1(30), SRC(3), TLN1(23)	19208856	187	111	180	96	60	31	23	45	26	2	0.997	1.000	1.000
357	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C8B(23), C9(12), MASP1(23)	16668527	202	110	192	65	59	26	22	52	41	2	0.515	1.000	1.000
358	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	19	GH1(5), GHR(12), HRAS(4), INSR(21), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), PLCG1(19), PRKCA(8), PTPN6(4), RPS6KA1(9), SHC1(14), SLC2A4(8), SOS1(16), SRF(4), STAT5A(10), STAT5B(20)	16763437	194	110	172	79	56	31	27	44	35	1	0.929	1.000	1.000
359	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(75), MAP2(60), PPP1CA(2), PPP2CA(3), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6), PRKCE(6)	12641543	175	109	151	56	36	40	23	39	37	0	0.395	1.000	1.000
360	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	22	ADCY1(27), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), HRAS(4), MAPK1(3), MAPK14(8), MAPK3(4), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAC1(2), RPS6KA1(9), RPS6KA5(13), SOS1(16)	15628224	170	109	161	60	57	39	19	35	20	0	0.297	1.000	1.000
361	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(11), CHIT1(12), CMAS(9), CTBS(6), CYB5R1(4), CYB5R3(2), GFPT1(6), GFPT2(12), GNE(8), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NAGK(7), NANS(2), NPL(4), PGM3(7), PHPT1(2), RENBP(3), UAP1(6)	19707803	200	109	191	56	74	36	24	38	28	0	0.0434	1.000	1.000
362	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(12), BAIAP2(7), CASP1(6), CASP3(4), CASP7(3), CASP8(20), GAPDH(2), INSR(21), ITCH(7), MAGI1(31), MAGI2(32), RERE(15), WWP1(21), WWP2(9)	16031074	190	109	176	70	53	31	28	38	39	1	0.659	1.000	1.000
363	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	19	BTK(12), DLG4(10), EPHB2(16), F2(10), F2RL2(8), JUN(2), MAP2K5(6), MAPK1(3), MAPK7(6), MAPK8(17), MYEF2(14), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RASAL1(9), SRC(3), TEC(10), VAV1(24)	17214330	210	109	205	78	69	42	25	50	24	0	0.621	1.000	1.000
364	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(16), FYN(17), LRP8(5), RELN(95), VLDLR(15)	9756132	156	107	129	50	41	38	17	39	21	0	0.116	1.000	1.000
365	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(27), ARHGDIB(5), BIRC2(7), BIRC3(18), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), GZMB(5), LMNA(1), LMNB1(11), LMNB2(3), PRF1(8)	13214043	162	106	135	55	30	36	14	44	38	0	0.763	1.000	1.000
366	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), TNFAIP3(42), TRAF3(12), TRAF6(4)	12705040	167	106	149	51	41	47	16	32	31	0	0.193	1.000	1.000
367	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	19	F2(10), F2R(11), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), PLA2G4A(16), PLCB1(23), PRKCA(8), PTGS1(10), PTK2(24), SRC(3), SYK(8), TBXAS1(13)	15953581	183	106	169	81	59	39	24	40	21	0	0.916	1.000	1.000
368	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(6), CASP2(8), CHUK(27), CRADD(4), IKBKB(9), IKBKG(2), JUN(2), LTA(1), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP4K2(6), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNF(2), TNFRSF1A(4), TRAF2(8)	15496295	184	106	168	63	53	43	19	42	27	0	0.375	1.000	1.000
369	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(10), CARS(11), DARS(5), EPRS(27), FARS2(7), GARS(8), HARS(6), IARS(10), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), NARS(5), QARS(14), RARS(9), SARS(6), TARS(10), WARS(4), WARS2(7), YARS(4)	22744531	192	105	186	44	58	26	28	52	28	0	0.0199	1.000	1.000
370	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1D1(9), ARSB(10), ARSD(9), ARSE(4), CYP11B1(17), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10)	18133225	189	105	176	53	66	24	23	36	40	0	0.0359	1.000	1.000
371	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	18	CCL11(2), CCR3(11), CFL1(2), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), LIMK1(8), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), NOX1(4), PIK3C2G(21), PLCB1(23), PRKCA(8), PTK2(24), ROCK2(20)	13433656	163	105	154	62	42	32	16	44	28	1	0.775	1.000	1.000
372	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	15	ADCY1(27), ARHGEF1(15), F2(10), F2R(11), GNA12(7), GNA13(3), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), MAP3K7(9), PLCB1(23), PRKCA(8), PTK2B(13), ROCK1(35)	13450290	181	105	162	72	55	35	11	44	32	4	0.935	1.000	1.000
373	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12), MASP1(23), MASP2(10), MBL2(3)	17012866	192	104	183	67	54	22	21	51	42	2	0.740	1.000	1.000
374	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	BCAR1(6), CXCL12(2), CXCR4(7), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), NFKB1(11), PIK3C2G(21), PLCG1(19), PRKCA(8), PTK2(24), PTK2B(13), PXN(2), RELA(10)	14649963	166	104	158	75	46	35	20	38	26	1	0.957	1.000	1.000
375	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(24), CPOX(4), EPRS(27), FECH(4), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UROD(3), UROS(5)	18782028	175	104	156	46	43	30	23	40	39	0	0.187	1.000	1.000
376	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	17	CSNK2A1(7), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), MPL(9), PLCG1(19), PRKCA(8), RASA1(24), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), THPO(6)	15324373	187	104	164	54	47	31	18	44	46	1	0.488	1.000	1.000
377	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	17	ADCY1(27), AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(22), IL3(6), KITLG(3), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), YWHAH(5)	9978503	132	103	121	48	52	31	7	25	17	0	0.406	1.000	1.000
378	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	11	ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), CSK(5), CTNNA1(28), CTNNA2(38), PTK2(24), PXN(2), SRC(3), VCL(10)	11167961	154	103	145	58	57	21	17	37	21	1	0.497	1.000	1.000
379	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	33	ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), GSR(5), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), TXNDC12(3)	12483769	167	103	148	41	36	33	24	51	23	0	0.0148	1.000	1.000
380	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(14), ADCY1(27), CAP1(5), CCNB1(8), CDC25C(6), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), MAPK1(3), MAPK3(4), MYT1(25), PIN1(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KA1(9), SRC(3)	12320017	154	102	147	49	61	29	20	31	13	0	0.0646	1.000	1.000
381	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	16	CALM2(1), CALM3(1), CDKN1A(2), GNAQ(11), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SP1(7), SP3(13), SYT1(14)	13023936	138	101	124	59	43	33	13	25	24	0	0.839	1.000	1.000
382	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(17), AGT(12), AGTR2(17), EDN1(3), EDNRA(9), EDNRB(19), EGF(8), FOS(5), HRAS(4), JUN(2), MYC(5), NFKB1(11), PLCG1(19), PRKCA(8), RELA(10)	12325333	149	101	133	56	42	24	24	32	27	0	0.690	1.000	1.000
383	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(8), AMD1(4), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTAP(3), MTFMT(1), MTR(14), SRM(1), TAT(16)	14116545	174	101	161	57	66	21	26	33	27	1	0.248	1.000	1.000
384	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(7), ABP1(4), AOC2(12), AOC3(10), CES1(14), CES7(1), ESCO1(22), ESCO2(18), LIPA(3), MYST3(34), MYST4(33), NAT6(2), PLA1A(10), PNPLA3(6), PPME1(2), PRDX6(5), SH3GLB1(6)	16351661	189	101	172	72	50	35	24	49	30	1	0.702	1.000	1.000
385	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	ASAH1(4), CAMP(1), CASP3(4), CERK(3), CREB1(3), CREB3(6), CREB5(8), DAG1(10), EPHB2(16), FOS(5), GNAQ(11), ITPKA(3), ITPKB(15), JUN(2), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13)	12693711	160	101	153	51	43	32	17	40	28	0	0.188	1.000	1.000
386	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(44), APOA1(3), APOA4(6), APOC1(1), APOC2(2), APOE(1), CETP(12), CYP7A1(14), DGAT1(5), HMGCR(7), LCAT(4), LDLR(11), LIPC(6), LPL(12), LRP1(53), SCARB1(4), SOAT1(6)	18004821	191	101	181	71	65	30	25	48	23	0	0.546	1.000	1.000
387	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), HAL(12)	14785991	161	100	152	58	50	29	19	38	25	0	0.631	1.000	1.000
388	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(15), DRD1(9), DRD2(9), GRM1(37), PLCB1(23), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	10797443	147	99	133	54	50	35	7	33	22	0	0.565	1.000	1.000
389	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(16), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPHN(18), NSF(4), SRC(3), UBQLN1(6)	8469740	155	99	140	47	40	22	17	51	25	0	0.205	1.000	1.000
390	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	13	ERCC3(19), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC3(3), NCOA1(15), NCOA2(23), NCOA3(21), NCOR2(44), POLR2A(14), RARA(6), RXRA(8), TBP(2)	15709380	181	99	163	83	52	29	29	36	35	0	0.988	1.000	1.000
391	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(12), EEA1(19), GRASP(3), GSK3A(6), GSK3B(17), LYN(13), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PLCG1(19), PRKCE(6), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(9)	15395130	170	98	159	57	53	35	23	29	29	1	0.370	1.000	1.000
392	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(27), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP7(3), CASP8(20), CASP9(6), DFFA(6), DFFB(2), GZMB(5), PRF1(8), SCAP(9), SREBF1(8), SREBF2(10)	11809219	140	98	120	47	28	25	16	38	33	0	0.596	1.000	1.000
393	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(12), ACO2(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), PC(16), PCK1(6), SDHA(14), SDHB(3), SUCLA2(9), SUCLG1(3), SUCLG2(1)	13467799	128	96	119	52	38	19	18	34	19	0	0.745	1.000	1.000
394	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	20	AKT1(11), AXIN1(10), CCND1(2), CD14(6), FZD1(9), GJA1(9), GNAI1(5), GSK3B(17), IRAK1(6), LBP(8), LEF1(9), LY96(4), MYD88(4), NFKB1(11), PDPK1(4), PPP2CA(3), RELA(10), TIRAP(5), TLR4(18), TOLLIP(5)	11383867	156	96	149	48	51	37	22	23	22	1	0.0712	1.000	1.000
395	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(5), ALOX5(12), CYP1A2(11), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), HSD3B7(3), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	16709635	177	96	169	62	62	35	18	48	13	1	0.325	1.000	1.000
396	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR7(7), CD28(5), CD4(4), CXCR3(5), CXCR4(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18R1(16), IL2(5), IL4(5), IL4R(6), TGFB1(2), TGFB2(10), TGFB3(2)	14143712	159	96	145	62	34	37	21	45	21	1	0.641	1.000	1.000
397	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(7), CREBBP(81), DFFA(6), DFFB(2), GZMA(11), GZMB(5), HMGB2(2), NME1(1), PRF1(8), SET(6)	7165757	130	96	119	51	34	31	14	31	20	0	0.666	1.000	1.000
398	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(7), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GCNT2(26), ST3GAL6(16), ST8SIA1(10)	9215862	142	95	131	33	48	20	11	41	21	1	0.0228	1.000	1.000
399	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	16	CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PLCG1(19), PTPN6(4), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20)	11764340	141	94	124	47	38	23	14	32	33	1	0.762	1.000	1.000
400	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(10), SMPD2(3), SPTLC1(12), SPTLC2(9), UGCG(9)	15097703	165	94	155	62	50	30	22	43	20	0	0.538	1.000	1.000
401	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), XYLB(6)	17778277	187	94	169	46	33	30	23	55	46	0	0.143	1.000	1.000
402	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	26	ATG3(4), ATG7(1), BECN1(3), GABARAPL1(1), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(29), PIK3R4(21), PRKAA1(9), PRKAA2(20), ULK2(14), ULK3(3)	12938288	156	94	140	48	26	36	22	49	22	1	0.348	1.000	1.000
403	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(4), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(7), EDN1(3), EDNRA(9), EDNRB(19), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(16), PRL(4), PTGDR(9), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	14267644	160	93	151	58	59	18	14	46	23	0	0.566	1.000	1.000
404	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(11), F13A1(15), F2(10), F2R(11), FGA(23), FGB(6), FGG(7), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10)	9577865	148	92	137	52	41	26	25	33	23	0	0.490	1.000	1.000
405	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	24	AKR1B1(6), ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), GCK(6), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), KHK(4), MPI(4), PFKFB1(14), PFKFB3(3), PFKFB4(5), PFKM(5), PFKP(16), PMM1(5), PMM2(2), SORD(2), TPI1(3)	15803791	154	92	145	59	62	19	15	38	20	0	0.581	1.000	1.000
406	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	25	AHCY(8), CARM1(3), CBS(4), CTH(6), HEMK1(1), LCMT1(1), LCMT2(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), METTL2B(3), METTL6(8), PAPSS1(5), PAPSS2(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SCLY(12), SEPHS1(7), SEPHS2(5), WBSCR22(2)	15946771	156	92	152	51	42	27	22	41	24	0	0.240	1.000	1.000
407	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), GLCE(8), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), NDST1(10), NDST2(10), NDST3(19), NDST4(13)	13840841	152	92	147	57	58	29	13	34	18	0	0.646	1.000	1.000
408	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	18	CCR5(11), CD3D(5), CD3E(2), CXCR3(5), ETV5(15), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), JUN(2), MAP2K6(5), MAPK14(8), MAPK8(17), STAT4(13), TYK2(5)	10996527	138	91	126	53	25	34	21	41	17	0	0.724	1.000	1.000
409	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	21	CALM2(1), CALM3(1), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), HDAC5(14), MEF2A(7), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(5), PPP3CB(11), PPP3CC(7), SLC2A4(8), SYT1(14), YWHAH(5)	12803247	141	91	135	67	43	31	11	30	26	0	0.958	1.000	1.000
410	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(5), CHAT(17), DBH(9), DDC(5), GAD1(17), GAD2(15), HDC(14), MAOA(7), PAH(17), PNMT(3), SLC18A3(12), TPH1(4)	9026307	127	90	119	54	42	19	12	44	10	0	0.746	1.000	1.000
411	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	16	AKT1(11), BCL2(2), BCR(12), CRKL(5), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), MYC(5), SOS1(16), STAT1(17), STAT5A(10), STAT5B(20)	12475121	163	90	152	41	46	27	21	41	28	0	0.0396	1.000	1.000
412	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	15	B3GALT4(4), GLB1(9), HEXA(4), HEXB(5), LCT(46), SLC33A1(10), ST3GAL1(3), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10)	10634557	138	90	123	52	50	33	13	31	11	0	0.491	1.000	1.000
413	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(7), CHUK(27), IFNG(3), IKBKB(9), IL2(5), IL4(5), JUN(2), MAP3K1(21), MAP3K5(16), MAP4K5(4), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), TNFRSF9(10), TRAF2(8)	13368999	164	89	147	40	44	41	16	44	19	0	0.0246	1.000	1.000
414	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	8	CSF1R(16), EGF(8), PDGFRA(64), PRKCA(8), SH3GLB1(6), SH3GLB2(6), SH3KBP1(8), SRC(3)	8407613	119	89	108	56	18	36	17	35	11	2	0.924	1.000	1.000
415	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(19), CD2(7), CD33(3), CD5(9), CD7(6), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(18), TLR2(12), TLR4(18), TLR7(18), TLR9(16)	12701615	161	89	149	61	52	24	17	50	16	2	0.545	1.000	1.000
416	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2)	12938978	142	89	134	52	46	36	15	31	14	0	0.421	1.000	1.000
417	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(8), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTR(14)	11950916	149	89	139	46	57	20	19	27	25	1	0.207	1.000	1.000
418	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	11	ARHGEF1(15), GNA12(7), GNA13(3), GNAQ(11), GNB1(3), GNGT1(1), MYL2(2), MYLK(33), PLCB1(23), PRKCA(8), ROCK1(35)	10954240	141	89	128	55	36	21	15	37	28	4	0.862	1.000	1.000
419	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(22), AP2A1(5), AP2M1(6), BIN1(6), CALM2(1), CALM3(1), DNM1(16), EPN1(10), EPS15(14), NME1(1), PICALM(9), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYNJ1(28), SYNJ2(15), SYT1(14)	15355004	171	89	155	70	48	30	17	44	32	0	0.798	1.000	1.000
420	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(27), MAP3K14(6), MAPK14(8), MAPK8(17), NFKB1(11), RELA(10), TNFRSF13B(7), TNFRSF17(4), TNFSF13(2), TNFSF13B(4), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4)	9700198	133	89	120	38	44	29	10	25	25	0	0.211	1.000	1.000
421	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CD80(6), CR1(20), CR2(22), FCGR2B(2), HLA-DRB1(7), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	9581861	136	88	134	46	31	19	22	33	29	2	0.549	1.000	1.000
422	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	12	CD28(5), CD3D(5), CD3E(2), CD80(6), CD86(2), CTLA4(5), HLA-DRB1(7), ICOS(2), IL2(5), ITK(26), LCK(9), PTPN11(41)	5361659	115	88	90	40	20	42	12	27	12	2	0.546	1.000	1.000
423	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	24	ALDOA(2), ALDOC(3), DERA(4), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKL(7), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TALDO1(4), TKT(7), TKTL1(8), TKTL2(15)	14765877	149	88	145	55	55	20	21	39	14	0	0.373	1.000	1.000
424	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	15	ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), NAGLU(6), SPAM1(13)	12683075	155	88	139	52	51	31	14	40	19	0	0.359	1.000	1.000
425	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AGPS(6), CHPT1(4), ENPP2(27), ENPP6(11), PAFAH1B1(6), PAFAH1B3(2), PAFAH2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PPAP2A(2), PPAP2B(2), PPAP2C(3)	16146603	163	88	153	72	57	30	21	37	18	0	0.931	1.000	1.000
426	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	15	BCAT1(5), BCAT2(1), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), ILVBL(9), PANK1(7), PANK2(1), PANK4(8), PPCS(4), UPB1(9), VNN1(13)	10831817	144	88	136	46	32	26	28	41	16	1	0.196	1.000	1.000
427	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), SELE(13), SELL(5), SELP(15)	10693526	129	88	131	44	41	21	13	31	23	0	0.374	1.000	1.000
428	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	11	ARNT(9), ASPH(15), COPS5(2), CREB1(3), EDN1(3), EP300(56), EPO(1), HIF1A(16), JUN(2), NOS3(23), P4HB(6)	10468417	136	87	115	41	33	26	18	27	32	0	0.312	1.000	1.000
429	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME3(8), PGK1(3), PGK2(10), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TKTL1(8), TKTL2(15), TPI1(3)	13081759	134	87	128	56	43	17	16	42	16	0	0.793	1.000	1.000
430	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	AKT1(11), IL2RG(9), IL4(5), IL4R(6), IRS1(21), JAK1(22), JAK3(31), RPS6KB1(9), SHC1(14), STAT6(4)	9211118	132	87	106	36	33	24	17	19	37	2	0.285	1.000	1.000
431	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	20	ALG3(2), ALG5(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), DDOST(4), DPM1(3), FUT8(11), MAN1A1(14), MAN1B1(7), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), RPN1(4), RPN2(7), ST6GAL1(3)	12079498	137	87	129	51	41	31	15	29	21	0	0.765	1.000	1.000
432	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	13	EGF(8), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), PTPRB(21), RASA1(24), SHC1(14), SOS1(16), SPRY1(10), SPRY2(2), SPRY4(7), SRC(3)	11863913	128	87	114	39	26	28	20	27	26	1	0.359	1.000	1.000
433	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(2), IL6(7), IL6R(8), JAK1(22), JAK3(31), PIAS3(10), PTPRU(24), REG1A(8), SRC(3), STAT3(10)	8703815	125	87	106	41	50	22	19	15	18	1	0.242	1.000	1.000
434	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6)	11082560	143	86	125	51	34	32	15	37	24	1	0.663	1.000	1.000
435	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(15), BST1(3), C9orf95(2), CD38(5), ENPP1(17), ENPP3(12), NADK(8), NADSYN1(4), NMNAT1(3), NMNAT2(5), NMNAT3(5), NNMT(6), NNT(8), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT12(3), QPRT(2)	15172522	146	86	139	52	45	27	17	36	20	1	0.362	1.000	1.000
436	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	17	BAD(1), BCL2(2), CASP8(20), CYCS(1), FADD(1), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFKB1(11), NSMAF(13), RELA(10), RIPK1(7), SMPD1(10), TNFRSF1A(4), TRAF2(8)	12047076	145	85	136	44	45	26	15	32	27	0	0.168	1.000	1.000
437	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12)	14305523	156	85	147	50	44	16	16	39	39	2	0.659	1.000	1.000
438	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	17	AKT1(11), BAD(1), BCL2L1(1), CASP9(6), CDC42(3), CHUK(27), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(12), MAPK3(4), NFKB1(11), RAC1(2), RALA(8), RALBP1(8), RALGDS(9), RELA(10)	9003230	122	85	109	33	45	23	17	21	16	0	0.0408	1.000	1.000
439	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(27), GNB1(3), GNGT1(1), PPP2CA(3), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	9156380	120	84	111	40	45	23	7	26	19	0	0.338	1.000	1.000
440	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(16), PGAP1(14), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGW(2), PIGX(4), PIGZ(6)	16362410	139	84	130	57	24	30	13	44	28	0	0.933	1.000	1.000
441	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC1(25), ABCC2(23), ABCG2(17), CES1(14), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10)	15469541	155	84	137	54	44	27	20	35	28	1	0.428	1.000	1.000
442	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), HAL(12)	13277194	136	84	127	51	41	26	17	29	23	0	0.731	1.000	1.000
443	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), PON1(12), PON2(7), PON3(14)	11598072	139	83	126	46	37	31	14	34	21	2	0.351	1.000	1.000
444	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(7), CAT(8), EPX(14), LPO(10), MPO(17), MTHFR(9), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36)	7671411	118	83	106	32	54	14	13	21	16	0	0.0871	1.000	1.000
445	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	11	IL10RA(4), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(22), JAK3(31), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), TYK2(5)	10607636	127	83	106	40	32	27	10	28	29	1	0.600	1.000	1.000
446	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(7), ATP6V0C(1), CAT(8), EPX(14), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36)	7751352	117	83	105	34	55	14	13	18	17	0	0.106	1.000	1.000
447	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(7), FOS(5), GNAQ(11), JUN(2), MAPK14(8), MAPK8(17), PLCG1(19), PRKCA(8), PTK2B(13), SYT1(14)	9455777	120	82	108	51	26	31	9	36	18	0	0.944	1.000	1.000
448	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(13), ERBB4(65), NRG2(8), NRG3(18), PRKCA(8), PSEN1(4)	6360313	116	82	106	39	23	22	20	34	17	0	0.448	1.000	1.000
449	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	14	AKT1(11), CREB1(3), HRAS(4), MAPK1(3), MAPK3(4), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NTRK1(17), PLCG1(19), RPS6KA1(9), SHC1(14)	9854700	115	82	108	49	32	26	17	18	21	1	0.914	1.000	1.000
450	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(10), F2R(11), F3(2), F5(37), F7(7), FGA(23), FGB(6), FGG(7), PROC(3), PROS1(12), SERPINC1(8), TFPI(9)	11211396	140	82	131	54	37	29	20	38	16	0	0.723	1.000	1.000
451	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	14	CSNK2A1(7), DPM2(1), ELK1(4), FOS(5), HRAS(4), JUN(2), KLK2(4), MAP2K1(12), MAPK3(4), MAPK8(17), NGFR(5), PLCG1(19), SHC1(14), SOS1(16)	8943849	114	82	104	38	30	23	13	26	21	1	0.629	1.000	1.000
452	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(11), AKT2(8), AKT3(8), CDKN1A(2), ELK1(4), HRAS(4), MAP2K1(12), MAP2K2(3), NGFR(5), NTRK1(17), PIK3CD(11), SHC1(14), SOS1(16)	8630790	115	82	106	45	34	17	20	25	18	1	0.716	1.000	1.000
453	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	10	ARNTL(14), CRY1(17), CRY2(5), CSNK1D(15), CSNK1E(9), NPAS2(10), NR1D1(8), PER1(13), PER2(9), PER3(20)	10164008	120	81	105	30	44	27	8	31	9	1	0.0159	1.000	1.000
454	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	CISH(2), JAK1(22), JAK3(31), PIAS1(4), PIAS3(10), PTPRU(24), REG1A(8), SOAT1(6)	7497143	107	81	94	33	41	21	13	13	18	1	0.232	1.000	1.000
455	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(6), ALDH18A1(8), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), GAMT(6), GATM(2), GLUD1(4), NAGS(6), OAT(4), ODC1(8), OTC(17), SMS(4)	11898702	137	81	127	38	39	29	19	33	17	0	0.0859	1.000	1.000
456	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(6), ACADM(12), ACADS(4), ACADVL(6), ACSL1(9), ACSL3(12), ACSL4(10), CPT1A(13), CPT2(3), DCI(4), EHHADH(15), HADHA(12), SCP2(6), SLC25A20(2)	11733185	114	80	103	44	29	21	15	31	18	0	0.588	1.000	1.000
457	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2)	10562813	122	80	115	37	37	31	14	26	14	0	0.145	1.000	1.000
458	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PGK1(3), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TPI1(3)	11584757	110	79	104	44	33	15	14	33	15	0	0.705	1.000	1.000
459	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	14	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4)	8382047	113	79	102	33	27	24	17	30	15	0	0.153	1.000	1.000
460	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(27), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(7), BIRC3(18), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), DIABLO(3), ENDOG(3)	9080806	111	79	93	29	20	19	16	29	27	0	0.247	1.000	1.000
461	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	21	ALDOA(2), ALDOC(3), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TAL1(3), TALDO1(4), TKT(7)	12361874	118	79	113	44	44	16	13	34	11	0	0.475	1.000	1.000
462	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(11), BAD(1), CHRNB1(10), CHRNG(8), MUSK(15), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(10), YWHAH(5)	8089926	105	78	99	42	30	23	14	19	19	0	0.701	1.000	1.000
463	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), NCK1(1), NCKAP1(17), NTRK1(17), PIR(2), PSMA7(2), RAC1(2), WASF1(6), WASF2(5), WASF3(17), WASL(18)	10790657	130	78	123	44	36	16	19	36	23	0	0.488	1.000	1.000
464	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(14), APAF1(27), BCL2(2), CASP3(4), CASP9(6), CYCS(1), DAXX(18), FAS(9), FASLG(3), HSPB2(3), IL1A(1), MAPKAPK2(5), MAPKAPK3(6), TNF(2)	7422406	101	78	81	37	18	30	13	17	23	0	0.755	1.000	1.000
465	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(36), CPT1A(13), LEP(1), LEPR(21), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7)	10370628	122	78	115	36	38	14	12	39	19	0	0.407	1.000	1.000
466	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(35), ABCB11(19), ABCB4(28), ABCC1(25), ABCC3(11), GSTP1(1)	9746347	119	78	123	37	23	20	18	32	24	2	0.409	1.000	1.000
467	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), PAK1(11), PDGFRA(64), RAC1(2), WASL(18)	6876027	127	77	114	42	23	31	16	39	16	2	0.398	1.000	1.000
468	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), CHST1(10), CHST2(13), CHST4(8), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	7278265	103	77	101	36	51	17	4	17	14	0	0.596	1.000	1.000
469	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	11	CSF2RB(13), FOS(5), HRAS(4), IL3(6), MAP2K1(12), MAPK3(4), PTPN6(4), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20)	8532275	108	77	92	32	30	16	10	21	30	1	0.590	1.000	1.000
470	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(27), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(4), CASP8(20), CASP9(6), CYCS(1), GZMB(5), JUN(2), PRF1(8)	6864885	91	76	75	32	17	19	9	20	26	0	0.742	1.000	1.000
471	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(8), MAP2K1(12), MAP3K1(21), MAPK14(8), NCOR2(44), RARA(6), RXRA(8), THRA(6), THRB(14)	9282735	127	76	110	40	36	19	19	24	29	0	0.478	1.000	1.000
472	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	11	BCAT1(5), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), PANK1(7), PANK2(1), PANK4(8), PPCS(4), UPB1(9)	8512037	121	76	114	35	22	22	24	36	16	1	0.138	1.000	1.000
473	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(25), C5(25), C6(27), C7(11), C8A(14), C9(12)	8778922	114	75	107	35	35	11	13	30	24	1	0.385	1.000	1.000
474	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(1), IARS(10), IARS2(19), ILVBL(9), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3), VARS(7), VARS2(9)	11405023	107	75	105	41	42	17	14	19	15	0	0.723	1.000	1.000
475	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(2), MRPL13(8), MRPS7(4), RPL10A(3), RPL10L(4), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(4), RPL7(4), RPL8(3), RPL9(4), RPS10(2), RPS11(2), RPS13(2), RPS15A(1), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS5(2), RPS6(3), RPS7(1), RPS9(3), RPSA(1)	13694342	122	75	117	32	29	27	20	31	15	0	0.152	1.000	1.000
476	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2)	16195591	124	75	119	31	38	17	25	27	17	0	0.0476	1.000	1.000
477	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(24), CLTA(6), CLTB(3), COPA(14), GBF1(19), GPLD1(16), KDELR1(5), KDELR2(9), KDELR3(2)	11408612	110	74	106	39	31	21	14	22	22	0	0.652	1.000	1.000
478	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), PHPT1(2), RFK(1), TYR(12)	10560919	120	74	107	38	35	30	14	22	17	2	0.292	1.000	1.000
479	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	9	AKT1(11), DPM2(1), HRAS(4), KLK2(4), NTRK1(17), PLCG1(19), PRKCA(8), SHC1(14), SOS1(16)	7738727	94	74	81	41	17	21	17	19	19	1	0.947	1.000	1.000
480	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(4), LCT(46), MPI(4), PGM1(10), PYGL(8), PYGM(12), TPI1(3), TREH(6)	9210110	106	73	98	34	34	22	15	28	7	0	0.170	1.000	1.000
481	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), IDS(5), LCT(46), NAGLU(6)	9533781	106	73	97	37	39	21	10	25	11	0	0.315	1.000	1.000
482	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELE(13), SELL(5)	8270708	100	73	98	38	27	17	9	26	21	0	0.696	1.000	1.000
483	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	16	IL18(3), ITGB1(13), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LAT(3), MAP2K1(12), MAPK3(4), PAK1(11), PTK2B(13), PTPN6(4), RAC1(2), SYK(8), VAV1(24)	9838256	116	73	111	39	32	26	11	32	15	0	0.431	1.000	1.000
484	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42)	11478171	122	71	108	39	37	15	21	31	18	0	0.356	1.000	1.000
485	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(5), CD3D(5), CD3E(2), IFNG(3), IL2(5), IL2RA(6), IL4(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), TOB1(8), TOB2(2)	7211875	118	71	102	39	37	29	13	23	16	0	0.297	1.000	1.000
486	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(9), CYB5R3(2), GCK(6), GFPT1(6), GNE(8), GNPDA1(2), GNPDA2(3), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), PGM3(7), RENBP(3), UAP1(6)	11659061	103	70	97	31	35	24	12	19	13	0	0.192	1.000	1.000
487	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(13), AMT(2), ATIC(14), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6)	12911227	107	70	101	51	33	17	16	22	17	2	0.944	1.000	1.000
488	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(5), CSF3(3), HLA-DRB1(7), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL11(6), IL12A(2), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), LTA(1), PDGFA(2), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2)	8684335	103	70	93	45	30	18	9	29	14	3	0.887	1.000	1.000
489	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(11), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK1(3), MAPK3(4), MYC(5), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10), TNF(2)	9427428	101	69	96	46	30	17	16	22	16	0	0.870	1.000	1.000
490	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(2), FH(10), IDH2(17), MDH1(8), OGDH(14), SDHA(14), SUCLA2(9)	6549626	81	69	71	29	22	15	8	22	14	0	0.581	1.000	1.000
491	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	10	AKT1(11), CAT(8), GH1(5), GHR(12), HRAS(4), IGF1(6), IGF1R(22), SHC1(14), SOD2(4)	6289138	86	69	74	35	27	13	12	19	14	1	0.768	1.000	1.000
492	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), FDXR(5), SHMT1(7)	10471669	103	69	91	40	31	27	13	21	11	0	0.635	1.000	1.000
493	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(6), JAK1(22), PTPRU(24), REG1A(8), STAT1(17), STAT2(12), TYK2(5)	8526878	101	69	92	27	39	21	8	18	14	1	0.133	1.000	1.000
494	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(11), BAD(1), CASP9(6), CHUK(27), GH1(5), GHR(12), NFKB1(11), NFKBIA(1), PDPK1(4), PPP2CA(3), RELA(10), YWHAH(5)	7217989	96	68	84	31	31	21	12	21	11	0	0.293	1.000	1.000
495	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10003471	98	68	86	39	30	26	13	19	10	0	0.675	1.000	1.000
496	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(14), EIF2AK4(23), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF5(6), GSK3B(17), PPP1CA(2)	7874754	85	68	72	21	14	31	6	15	19	0	0.136	1.000	1.000
497	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10003471	98	68	86	39	30	26	13	19	10	0	0.675	1.000	1.000
498	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(2), BNIP1(5), GOSR1(5), GOSR2(6), SEC22B(3), SNAP23(2), SNAP25(2), SNAP29(4), STX11(7), STX12(6), STX16(7), STX17(2), STX18(3), STX19(4), STX2(6), STX3(4), STX4(3), STX5(11), STX6(2), STX7(4), STX8(7), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(4), VAMP4(4), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1), YKT6(1)	11075338	124	68	111	35	39	12	11	29	33	0	0.381	1.000	1.000
499	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(5), CD86(2), HLA-DRB1(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), IL2(5), IL2RA(6), IL4(5), IL4R(6)	8376012	99	68	89	32	23	19	14	24	16	3	0.324	1.000	1.000
500	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10003471	98	68	86	39	30	26	13	19	10	0	0.675	1.000	1.000
501	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	10	ADCY1(27), ADRB2(3), CFTR(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SLC9A3R1(3)	7469956	89	67	85	28	28	19	5	24	13	0	0.217	1.000	1.000
502	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2)	9410902	88	67	89	34	19	21	9	26	13	0	0.734	1.000	1.000
503	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(4), GALNT10(8), GALNT2(15), GALNT3(15), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GCNT1(9), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4)	9088904	93	67	91	39	35	18	14	12	14	0	0.737	1.000	1.000
504	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(13), AMT(2), ATIC(14), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6)	12541796	102	67	94	49	30	18	15	21	16	2	0.941	1.000	1.000
505	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(11), PLCB1(23), PLCG1(19), PRKCA(8), VAV1(24)	6454376	85	67	78	38	28	22	11	18	6	0	0.875	1.000	1.000
506	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	14	ADRB2(3), AKT1(11), ANXA1(4), CALM2(1), CALM3(1), GNB1(3), GNGT1(1), NFKB1(11), NOS3(23), NPPA(1), NR3C1(11), RELA(10), SYT1(14)	7800652	94	66	77	36	28	26	9	15	16	0	0.669	1.000	1.000
507	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(19), PSMD11(8), PSMD12(6), PSMD13(8), PSMD2(4), PSMD6(8)	11487542	97	66	88	37	25	24	11	25	12	0	0.728	1.000	1.000
508	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10)	11835122	102	66	88	30	27	14	13	18	30	0	0.450	1.000	1.000
509	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(5), CD3D(5), CD3E(2), CD4(4), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	7473398	102	66	96	41	25	16	15	23	23	0	0.782	1.000	1.000
510	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(4), ALOX15(5), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(3), LTA4H(2), PLA2G6(10), PTGDS(2), PTGES(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	9336087	91	65	90	37	34	11	11	22	13	0	0.679	1.000	1.000
511	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(7), CD28(5), CD3D(5), CD3E(2), CD8A(2), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	7012128	100	65	94	39	27	16	13	22	22	0	0.712	1.000	1.000
512	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(3), EPO(1), FLT3(36), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(7), IL9(2), KITLG(3), TGFB1(2), TGFB2(10), TGFB3(2)	5817287	85	64	75	40	21	21	7	23	12	1	0.940	1.000	1.000
513	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(21), ESR2(8), ITPKA(3), PDE1A(10), PDE1B(11), PLCB1(23), PRL(4), TRH(8), VIP(3)	6133386	91	64	86	27	27	16	14	18	16	0	0.263	1.000	1.000
514	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	14	B3GAT1(6), B3GAT2(1), B3GAT3(2), B4GALT7(2), CHPF(10), CHST11(6), CHST12(6), CHST14(1), CHST3(7), CHSY1(14), DSE(10), UST(12), XYLT1(14)	7670173	91	63	82	48	40	16	12	15	7	1	0.922	1.000	1.000
515	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(6), ICAM1(4), ITGAL(21), ITGAM(14), ITGB2(18), SELE(13), SELL(5)	6781644	81	63	87	27	30	12	8	16	15	0	0.363	1.000	1.000
516	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), NAT1(1), NAT2(3), XDH(19)	5673381	77	62	72	34	25	13	10	21	8	0	0.858	1.000	1.000
517	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PCYT1A(5), PCYT1B(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2)	9317773	82	62	85	36	19	18	9	23	13	0	0.915	1.000	1.000
518	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(6), IL10(2), IL10RA(4), IL10RB(7), IL1A(1), IL6(7), JAK1(22), STAT1(17), STAT3(10), STAT5A(10), TNF(2)	8331374	92	62	80	35	30	16	6	22	17	1	0.735	1.000	1.000
519	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), STAT3(10), TYK2(5)	6186524	75	62	61	24	21	21	6	13	13	1	0.522	1.000	1.000
520	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), IMPA2(4), ISYNA1(6), PGM1(10), PGM3(7), TGDS(1)	7573819	80	61	75	33	33	12	8	18	9	0	0.607	1.000	1.000
521	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(8), IFNAR1(7), IFNAR2(4), IFNB1(6), JAK1(22), STAT1(17), STAT2(12), TYK2(5)	7400082	81	61	70	24	22	18	6	21	13	1	0.355	1.000	1.000
522	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(13), ADSS(8), DHFR(1), HPRT1(2), IMPDH1(4), MTHFD2(2), POLB(6), POLD1(20), POLG(9), PRPS2(6), RRM1(3), SRM(1)	8300600	75	61	74	31	28	7	12	14	14	0	0.783	1.000	1.000
523	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(3), DFFA(6), DFFB(2), ENDOG(3), GZMB(5), HMGB1(2), HMGB2(2), TOP2A(24), TOP2B(25)	6083306	76	60	71	18	10	15	8	22	21	0	0.439	1.000	1.000
524	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(6), FDFT1(4), FDPS(6), GGCX(11), GGPS1(5), HMGCR(7), IDI1(4), IDI2(3), LSS(5), MVD(3), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2), TM7SF2(2)	12365251	92	60	90	39	29	8	13	28	14	0	0.921	1.000	1.000
525	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	13	CCR5(11), CD2(7), CD3D(5), CD3E(2), CD4(4), CXCR3(5), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), STAT4(13), TYK2(5)	8337298	83	60	75	30	11	21	15	26	10	0	0.618	1.000	1.000
526	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(14), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(3), CDK5R1(5), CSNK1A1(3), CSNK1D(15), GSK3B(17), MAPT(11), PPP2CA(3)	5698340	81	60	77	27	29	20	5	17	10	0	0.413	1.000	1.000
527	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL15(1), IL16(18), IL18(3), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL8(6), IL9(2), LTA(1), TNF(2)	6679783	81	59	72	43	23	16	8	25	9	0	0.954	1.000	1.000
528	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(12), ACO2(7), AFMID(3), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2)	9484795	83	59	76	26	25	10	13	24	11	0	0.242	1.000	1.000
529	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(15), CD38(5), ENPP1(17), ENPP3(12), NADSYN1(4), NMNAT1(3), NMNAT2(5), NNMT(6), NNT(8), NT5C(1), NT5E(7), NT5M(3), QPRT(2)	10368086	88	59	81	32	24	19	10	22	12	1	0.425	1.000	1.000
530	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(6), CSF1(5), FCGR3A(5), IL1B(5), IL6R(8), SELL(5), SPN(6), TGFB1(2), TGFB2(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(8), TNFSF8(6)	8798591	87	59	89	29	26	12	16	19	14	0	0.272	1.000	1.000
531	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(18), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(3), CDK2(5), CDK4(4), CDKN1B(6), CDKN2A(9), E2F2(7), E2F4(2), PRB1(5)	5854733	71	59	67	30	15	14	9	19	14	0	0.783	1.000	1.000
532	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(12), ACO2(7), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2)	9047504	80	58	73	24	24	10	13	22	11	0	0.201	1.000	1.000
533	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(5), FOSL1(1), FOSL2(5), IFNAR1(7), IFNAR2(4), IFNB1(6), MAPK8(17), NFKB1(11), RELA(10), TNFRSF11A(6), TNFSF11(8), TRAF6(4)	7427319	84	58	82	32	25	17	9	18	15	0	0.615	1.000	1.000
534	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	13	CALM2(1), CALM3(1), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CAMKK1(2), CAMKK2(9), CREB1(3), SYT1(14)	7323562	73	57	67	36	16	20	9	14	14	0	0.942	1.000	1.000
535	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	15	CARS(11), CARS2(6), CDO1(3), CTH(6), GOT1(7), GOT2(2), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), SDS(3), SULT1B1(6), SULT1C2(6), SULT1C4(3), SULT4A1(6)	8113727	84	57	80	23	30	10	11	23	10	0	0.164	1.000	1.000
536	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	11	AHCY(8), CBS(4), CTH(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), PAPSS1(5), PAPSS2(7), SCLY(12), SEPHS1(7)	7802157	85	57	78	24	26	10	14	20	15	0	0.133	1.000	1.000
537	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10)	6419614	77	56	76	26	24	10	8	23	12	0	0.514	1.000	1.000
538	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(6), B3GALT5(5), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST8SIA1(10)	6872877	84	56	81	28	30	10	9	23	12	0	0.434	1.000	1.000
539	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), SIRT1(8), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(5)	7751289	68	56	63	25	21	11	10	13	13	0	0.530	1.000	1.000
540	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(7), UBE2A(5), UBE3A(25)	9226684	84	56	82	30	21	17	11	23	12	0	0.570	1.000	1.000
541	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(11), GNB1(3), GNGT1(1), HTR2C(15), PLCB1(23), TUB(14)	4961287	71	56	70	30	27	13	7	18	6	0	0.764	1.000	1.000
542	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	7	CD3D(5), CD3E(2), GZMB(5), ICAM1(4), ITGAL(21), ITGB2(18), PRF1(8)	4795831	63	55	58	28	27	9	3	9	15	0	0.805	1.000	1.000
543	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(5), GSR(5), GSS(9), IL8(6), NFKB1(11), NOX1(4), RELA(10), TNF(2), XDH(19)	6903227	71	55	66	23	17	22	7	11	14	0	0.457	1.000	1.000
544	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(8), ME1(14), PC(16), PDHA1(8), SLC25A1(1), SLC25A11(2)	6057386	63	55	57	21	23	15	7	11	7	0	0.344	1.000	1.000
545	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(5), MAX(5), MYC(5), SP1(7), SP3(13), WT1(32)	4179137	67	55	57	30	14	22	15	9	7	0	0.691	1.000	1.000
546	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(17), CHKA(6), PCYT1A(5), PDHA1(8), PDHA2(17), PEMT(2), SLC18A3(12)	4591510	72	54	70	43	30	9	10	18	5	0	0.968	1.000	1.000
547	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	12	CYSLTR1(9), GPR109B(5), GPR161(13), GPR171(11), GPR18(5), GPR34(11), GPR39(4), GPR45(14), GPR65(2), GPR68(5), GPR75(10)	6288152	89	54	80	40	26	14	7	23	18	1	0.915	1.000	1.000
548	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(19), CKM(7), FBL(6), GPT(7), LDHB(8), LDHC(4), MAPK14(8), NCL(12)	5543390	71	54	66	31	20	12	11	24	4	0	0.784	1.000	1.000
549	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(6), FARSB(12), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4), YARS2(7)	6150246	78	53	71	25	19	8	12	27	12	0	0.474	1.000	1.000
550	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	5223575	64	53	59	19	26	14	3	12	9	0	0.439	1.000	1.000
551	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), PGM1(10), PGM3(7), TGDS(1)	6907599	70	53	65	29	28	11	7	17	7	0	0.652	1.000	1.000
552	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(28), GNA12(7), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6)	7123468	64	52	60	17	17	10	7	17	13	0	0.286	1.000	1.000
553	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(7), B3GALT1(3), B3GALT2(10), B3GALT5(5), B3GNT5(3), FUT1(11), FUT2(7), FUT3(6), ST3GAL3(12), ST3GAL4(4)	4700899	68	52	64	25	31	7	4	15	11	0	0.675	1.000	1.000
554	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(11), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10)	5746565	64	52	61	28	21	12	7	15	9	0	0.840	1.000	1.000
555	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	6	IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), TYK2(5)	5480414	58	52	48	19	14	20	0	16	7	1	0.566	1.000	1.000
556	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	6	IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), TYK2(5)	5480414	58	52	48	19	14	20	0	16	7	1	0.566	1.000	1.000
557	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(3), HBXIP(4), HRAS(4), PTK2B(13), SHC1(14), SOS1(16), SRC(3)	5655159	57	51	51	18	7	11	9	13	16	1	0.688	1.000	1.000
558	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	7	CAMK1G(7), HDAC9(20), MEF2A(7), MEF2C(15), MEF2D(3), YWHAH(5)	4268471	57	51	67	29	16	8	3	19	10	1	0.967	1.000	1.000
559	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14)	8476258	73	51	71	20	26	13	8	16	10	0	0.273	1.000	1.000
560	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	5164061	61	50	61	26	29	6	6	11	9	0	0.710	1.000	1.000
561	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	9	AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	5164061	61	50	61	26	29	6	6	11	9	0	0.710	1.000	1.000
562	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	6	CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(11), NEK1(20)	4166285	58	50	55	22	10	12	3	16	16	1	0.923	1.000	1.000
563	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), RFK(1), TYR(12)	6843528	74	49	65	20	20	19	9	15	9	2	0.146	1.000	1.000
564	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(2), CDK2(5), CDK4(4), CDKN1A(2), CDKN1B(6), CDKN2A(9), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(5)	4661823	59	49	55	21	10	14	8	11	16	0	0.632	1.000	1.000
565	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(6), FARS2(7), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4)	5934868	65	48	59	28	15	7	14	20	9	0	0.857	1.000	1.000
566	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	8	CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CSK(5), PRKCA(8), PTPRA(6), SRC(3)	6057822	58	48	58	24	16	12	7	18	5	0	0.680	1.000	1.000
567	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(5), UBE2A(5), UBE2B(3), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(4), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(25)	7020427	74	48	72	22	20	13	6	17	18	0	0.275	1.000	1.000
568	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	10	ARRB1(4), GNB1(3), GNGT1(1), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8)	5300730	51	47	50	26	16	13	1	11	10	0	0.900	1.000	1.000
569	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), ECHS1(4), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), MECR(4), PPT1(1), PPT2(5)	5881095	54	47	53	18	14	9	6	13	12	0	0.456	1.000	1.000
570	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(10), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3)	7048795	62	46	61	27	20	11	9	14	8	0	0.859	1.000	1.000
571	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	10	ARNT(9), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(16), NFKB1(11), NFKBIA(1), RELA(10), SOD2(4)	6983437	61	45	58	22	18	9	9	11	14	0	0.625	1.000	1.000
572	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(15), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(6), APOBEC3F(2), APOBEC3G(8), APOBEC4(9)	5191508	57	44	56	17	22	5	10	10	10	0	0.312	1.000	1.000
573	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ENO1(3), GPI(6), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(12), TPI1(3)	5302809	51	43	47	27	20	8	4	13	6	0	0.945	1.000	1.000
574	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	11	CD2(7), CD34(7), CD3D(5), CD3E(2), CD4(4), CD8A(2), CSF3(3), IL3(6), IL6(7), IL8(6), KITLG(3)	3875790	52	43	44	23	12	14	5	13	8	0	0.748	1.000	1.000
575	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3)	4996405	57	43	55	15	17	6	5	10	19	0	0.269	1.000	1.000
576	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(39), GLS(2), GLUD1(4), GOT1(7)	5422364	59	43	52	16	14	14	10	14	7	0	0.214	1.000	1.000
577	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(3), FOS(5), JUN(2), KEAP1(5), MAPK1(3), MAPK14(8), MAPK8(17), NFE2L2(7), PRKCA(8)	5625930	58	42	57	24	13	12	5	20	8	0	0.803	1.000	1.000
578	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	5	ARNTL(14), CRY1(17), CRY2(5), CSNK1E(9), PER1(13)	4457906	58	42	49	16	20	11	2	20	4	1	0.284	1.000	1.000
579	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(11), MBTPS1(14), MBTPS2(2), SCAP(9), SREBF1(8), SREBF2(10)	7338535	55	42	54	28	16	13	8	10	8	0	0.839	1.000	1.000
580	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), IDI1(4), LSS(5), MVD(3), NQO1(1), NQO2(3), PMVK(2), SC5DL(9), SQLE(2)	6633975	50	41	49	18	16	8	7	15	4	0	0.508	1.000	1.000
581	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	7	LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NFS1(6), PHPT1(2), THTPA(2)	4094658	48	41	46	15	17	8	6	9	8	0	0.519	1.000	1.000
582	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	BPNT1(9), CHST11(6), CHST12(6), PAPSS1(5), PAPSS2(7), SULT1A1(4), SULT1A2(4), SULT1E1(6), SULT2A1(6), SULT2B1(4), SUOX(5)	6526346	62	41	58	21	20	9	5	20	8	0	0.560	1.000	1.000
583	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(3), FOS(5), FYN(17), JUN(2), MAPK14(8), THBS1(14)	5017622	53	41	48	20	14	9	6	11	13	0	0.587	1.000	1.000
584	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(12), AOC3(10), CES1(14), ESD(5)	4004121	45	39	44	23	15	6	8	11	5	0	0.869	1.000	1.000
585	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(7), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), ST3GAL3(12)	2690635	48	39	45	19	26	5	3	9	5	0	0.593	1.000	1.000
586	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(19), PRKCA(8), PTK2B(13)	4596991	48	39	44	26	15	12	6	9	6	0	0.967	1.000	1.000
587	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(8), F13B(12), HSD17B1(2), HSD17B2(7), HSD17B3(6), HSD17B4(9), HSD3B1(6), HSD3B2(4)	5650953	54	39	52	23	18	10	7	13	6	0	0.646	1.000	1.000
588	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(3), DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), HMGCS1(1), IDI1(4), LSS(5), MVD(3), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2)	8185421	55	38	55	21	17	7	7	18	6	0	0.711	1.000	1.000
589	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(9), GAD1(17), HDC(14), PNMT(3), TPH1(4)	3543730	47	38	45	19	14	7	3	18	5	0	0.718	1.000	1.000
590	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(11), CYP2E1(11), NR1I3(5), PTGS1(10), PTGS2(10)	3714878	47	37	47	19	22	4	8	9	4	0	0.722	1.000	1.000
591	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(10), CYP11A1(7), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	4653077	45	37	43	26	18	7	7	7	6	0	0.916	1.000	1.000
592	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	5	ADCY1(27), GNB1(3), GNGT1(1), PRKACA(2), PRKAR1A(8)	2953999	41	37	38	17	18	10	2	8	3	0	0.574	1.000	1.000
593	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(11), NR1H3(16), NR1H4(9), RXRA(8)	3464000	46	36	39	21	14	9	6	6	11	0	0.904	1.000	1.000
594	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(12), ALAS2(12), CPOX(4), FECH(4), HMBS(5), PPOX(5), UROD(3), UROS(5)	5397606	51	36	47	13	21	8	5	11	6	0	0.344	1.000	1.000
595	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(6), ACADM(12), ACADS(4), ACAT1(7), ECHS1(4), HADHA(12)	3709116	45	35	43	19	12	6	6	8	13	0	0.746	1.000	1.000
596	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(7), GOT2(2), TAT(16), TYR(12)	3360193	42	35	34	22	11	6	11	11	3	0	0.911	1.000	1.000
597	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMB8(9), PSMB9(4)	5875820	44	35	43	19	9	5	5	17	8	0	0.855	1.000	1.000
598	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(7), ACAT2(9), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(1), HMGCS2(6), OXCT1(3), OXCT2(3)	5121005	36	33	34	14	13	6	3	7	7	0	0.701	1.000	1.000
599	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(7), CSF1(5), IL6(7), LDLR(11), LPL(12)	3651205	42	33	39	19	14	12	3	7	6	0	0.692	1.000	1.000
600	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(12), NR3C1(11), PPARG(4), RETN(2), RXRA(8), TNF(2)	3753014	41	33	37	25	10	8	8	8	7	0	0.970	1.000	1.000
601	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), DHFR(1), FPGS(4), GGH(2), SPR(7)	3636482	37	32	37	15	12	7	5	9	4	0	0.609	1.000	1.000
602	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14)	3089563	36	31	33	21	18	7	2	5	3	1	0.942	1.000	1.000
603	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14)	3089563	36	31	33	21	18	7	2	5	3	1	0.942	1.000	1.000
604	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(10), PRKCA(8), TGM2(17)	3400591	41	31	40	21	17	6	3	12	3	0	0.853	1.000	1.000
605	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	6	CARS(11), CTH(6), GOT1(7), GOT2(2), LDHB(8), LDHC(4)	4053858	38	30	36	12	15	4	5	10	4	0	0.439	1.000	1.000
606	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	7	OXA1L(7), SEC61A2(4), SRP19(1), SRP54(4), SRP68(13), SRP72(9)	4436588	38	29	38	10	9	7	6	13	3	0	0.298	1.000	1.000
607	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(5), IL1B(5), MST1(5), MST1R(14), TNF(2)	3518329	31	28	28	11	11	5	4	8	3	0	0.496	1.000	1.000
608	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	8	ASAH1(4), CAMP(1), CREB1(3), CREB3(6), CREB5(8), MAPK1(3), SRC(3), TERF2IP(4)	4144209	32	26	32	15	5	5	4	11	7	0	0.867	1.000	1.000
609	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(2), CCR3(11), HLA-DRB1(7), IL3(6)	1585747	26	25	21	12	5	9	0	7	3	2	0.937	1.000	1.000
610	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(8), ARG1(2), GLS(2), GLUD1(4), OAT(4), PRODH(5)	3682869	25	23	24	12	11	7	2	1	4	0	0.760	1.000	1.000
611	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(12), SNAP25(2), STX1A(4), VAMP2(1)	2245011	23	23	20	11	7	6	3	6	1	0	0.907	1.000	1.000
612	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(7), GOT2(2), TAT(16)	1889276	25	21	19	13	7	1	9	5	3	0	0.867	1.000	1.000
613	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	ASRGL1(1), GBA(4), GBA3(3), SHMT1(7), SHMT2(5)	2992441	20	19	23	11	8	1	2	4	5	0	0.935	1.000	1.000
614	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(7), ACAT2(9), HMGCL(1), OXCT1(3)	2416096	20	18	18	10	3	5	3	5	4	0	0.890	1.000	1.000
615	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(6), IFNG(3), IL12A(2), IL12B(1), IL18(3), IL2(5)	2128698	20	15	19	16	1	4	6	7	2	0	0.995	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	365947	1	1	1	2	1	0	0	0	0	0	0.955	1.000	1.000
