		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	359 (70%)	151	9.9999e-06	0.000376	9.9999e-06	0.000376	0.1099	0.424	0.56445	0.886	2e-05	0.000582	9.9999e-06	0.000376	0.00478	0.0612	9.9999e-06	0.000376	9.9999e-06	0.000376	9.9999e-06	0.000376
CDKN2A	112 (22%)	398	0.02385	0.191	9.9999e-06	0.000376	0.00214	0.0351	0.71808	0.962	0.02515	0.199	2e-05	0.000582	0.2146	0.592	0.056819	0.307	0.00223	0.0357	0.03938	0.242
PIK3CA	94 (18%)	416	0.26211	0.655	0.2062	0.586	0.77842	0.98	0.063159	0.326	0.04107	0.248	0.34176	0.757	0.0070499	0.0885	0.02322	0.188	0.44469	0.852	0.094719	0.389
NSD1	63 (12%)	447	0.00435	0.058	9.9999e-06	0.000376	0.25051	0.636	0.0149	0.152	2e-05	0.000582	9.9999e-06	0.000376	0.0025	0.0381	5.9999e-05	0.00142	9.9999e-06	0.000376	3e-05	8e-04
CASP8	55 (11%)	455	9.9999e-06	0.000376	9.9999e-06	0.000376	0.01573	0.155	0.35076	0.769	9.9999e-06	0.000376	9.9999e-06	0.000376	0.0089999	0.103	0.56786	0.886	0.00024	0.00549	0.13759	0.449
HRAS	29 (6%)	481	3e-05	8e-04	9.9999e-06	0.000376	0.3752	0.794	0.65305	0.922	0.00050999	0.0105	0.00229	0.0357	0.00073999	0.0148	0.12105	0.435	0.0214	0.178	0.17217	0.508
TGFBR2	23 (5%)	487	0.01242	0.133	0.057969	0.309	0.46583	0.856	0.90126	1	0.10328	0.413	0.95882	1	0.63744	0.911	0.57006	0.886	0.72685	0.962	0.5157	0.875
FAT1	114 (22%)	396	0.25972	0.652	9.9999e-06	0.000376	0.84786	1	0.48751	0.863	0.14525	0.469	0.00035	0.00772	0.87361	1	0.59546	0.889	0.00325	0.0452	0.10034	0.406
NOTCH1	87 (17%)	423	0.01515	0.152	4e-05	0.00102	0.057049	0.307	0.059489	0.313	9.9999e-06	0.000376	0.00141	0.0244	2e-05	0.000582	0.066419	0.327	0.0084899	0.101	0.03754	0.24
EPHA2	24 (5%)	486	0.49774	0.863	5.9999e-05	0.00142	0.75586	0.969	0.93268	1	0.30993	0.721	0.29086	0.702	0.89544	1	0.16423	0.498	0.10738	0.423	0.64915	0.921
HLA-B	24 (5%)	486	0.15649	0.489	0.00127	0.0239	1	1	0.22122	0.602	0.03528	0.24	0.063049	0.326	0.057009	0.307	0.20909	0.586	0.086149	0.373	0.03602	0.24
RAC1	15 (3%)	495	0.11114	0.424	0.03551	0.24	1	1	0.8344	1	0.03455	0.24	0.069219	0.334	0.45038	0.852	0.40609	0.808	0.18047	0.525	0.3247	0.744
NFE2L2	26 (5%)	484	0.49512	0.863	2e-05	0.000582	0.50122	0.863	0.87389	1	0.8462	1	0.46802	0.856	0.23315	0.614	0.49347	0.863	0.59744	0.889	0.3572	0.775
ZNF750	19 (4%)	491	0.21448	0.592	0.01059	0.119	0.76234	0.97	0.28769	0.7	0.0073199	0.0901	0.01518	0.152	0.01624	0.155	0.13251	0.444	0.050499	0.284	0.02203	0.181
PTEN	14 (3%)	496	0.67655	0.945	0.44907	0.852	0.83144	1	0.8331	1	0.080339	0.355	0.24582	0.629	0.37675	0.794	0.22376	0.604	0.114	0.424	0.11017	0.424
HLA-A	22 (4%)	488	0.00313	0.0452	0.00319	0.0452	1	1	0.63907	0.911	0.00473	0.0612	0.00256	0.0381	0.03644	0.24	0.12025	0.435	0.55206	0.886	0.47464	0.861
RB1	18 (4%)	492	0.60096	0.89	0.37144	0.791	0.35537	0.774	0.27296	0.672	0.03717	0.24	0.37703	0.794	0.15412	0.486	0.4971	0.863	0.38509	0.805	0.61817	0.899
MAPK1	9 (2%)	501	0.10528	0.419	0.53071	0.879	1	1	0.83482	1	0.45072	0.852	0.91862	1	0.4889	0.863	0.83717	1	1	1	0.73678	0.962
KDM6A	17 (3%)	493	0.02965	0.214	0.76632	0.971	0.14248	0.463	1	1	0.89884	1	0.38979	0.807	0.90747	1	0.86272	1	0.56358	0.886	0.58161	0.889
EP300	39 (8%)	471	0.44632	0.852	0.03478	0.24	0.56262	0.886	0.084779	0.372	0.0076299	0.0921	0.090999	0.383	0.55439	0.886	0.23737	0.618	0.03977	0.242	1	1
RASA1	17 (3%)	493	0.16788	0.504	0.069469	0.334	0.38774	0.806	0.7107	0.962	0.42351	0.829	0.49253	0.863	0.55231	0.886	0.40758	0.808	0.40372	0.808	0.16346	0.498
NAP1L2	7 (1%)	503	0.39147	0.808	0.58012	0.889	NA	NA	NA	NA	0.88428	1	0.48303	0.863	0.8098	0.999	0.89806	1	0.90086	1	0.60204	0.89
CREBBP	35 (7%)	475	0.02664	0.208	0.56502	0.886	0.74146	0.962	0.9324	1	0.13103	0.444	0.12994	0.444	0.48682	0.863	0.03563	0.24	0.059609	0.313	0.13093	0.444
CTCF	16 (3%)	494	0.050299	0.284	0.00135	0.0244	0.61385	0.898	0.52279	0.877	0.48155	0.863	0.27192	0.672	0.69213	0.947	0.90093	1	0.73695	0.962	0.76526	0.971
KEAP1	22 (4%)	488	0.12357	0.442	0.065339	0.327	0.6097	0.897	0.82699	1	0.094469	0.389	0.00138	0.0244	0.26772	0.664	0.0384	0.241	0.40921	0.808	0.070559	0.337
RHOA	10 (2%)	500	0.10333	0.413	0.57485	0.889	0.16837	0.504	0.2424	0.626	1	1	1	1	0.72521	0.962	0.56279	0.886	0.68712	0.947	0.69062	0.947
FBXW7	33 (6%)	477	0.45287	0.852	0.14968	0.479	0.50268	0.863	0.2324	0.614	0.1254	0.444	0.45669	0.852	0.29723	0.705	0.48321	0.863	0.20975	0.586	0.11298	0.424
TIGD4	7 (1%)	503	0.49698	0.863	0.77118	0.975	0.29232	0.702	0.83162	1	0.72012	0.962	0.39486	0.808	0.65272	0.922	0.3972	0.808	0.95595	1	0.68954	0.947
KRT5	11 (2%)	499	0.19431	0.558	0.7471	0.966	0.13002	0.444	0.22316	0.604	0.59283	0.889	0.6215	0.901	1	1	0.085579	0.373	0.81893	1	0.82006	1
SMAD4	14 (3%)	496	0.52831	0.878	0.85496	1	0.03824	0.241	0.87204	1	0.40217	0.808	0.78261	0.98	0.01954	0.169	0.49037	0.863	0.86409	1	0.41444	0.814
ASXL1	16 (3%)	494	0.72262	0.962	0.29542	0.704	0.62993	0.91	0.87622	1	0.075479	0.34	0.01699	0.158	0.056209	0.307	0.064599	0.326	0.83254	1	0.01128	0.124
CES2	11 (2%)	499	0.36918	0.791	0.53928	0.881	0.92969	1	1	1	0.43313	0.838	0.29881	0.706	0.46639	0.856	0.58743	0.889	0.97447	1	0.46818	0.856
IRS4	17 (3%)	493	0.19244	0.557	0.57037	0.886	0.25891	0.652	0.78993	0.985	0.12665	0.444	0.073149	0.34	0.21582	0.593	0.064319	0.326	0.01495	0.152	0.22117	0.602
ARID2	20 (4%)	490	0.32118	0.739	0.02967	0.214	0.61134	0.897	0.79513	0.99	0.22715	0.606	0.61465	0.898	0.16747	0.504	0.68094	0.947	0.52516	0.877	0.69082	0.947
CBWD1	5 (1%)	505	0.59358	0.889	0.80364	0.998	NA	NA	NA	NA	1	1	1	1	1	1	0.85462	1	0.83582	1	0.01248	0.133
RGL4	7 (1%)	503	0.52501	0.877	0.97785	1	0.055109	0.307	0.33772	0.753	0.80701	0.998	0.36255	0.784	0.43003	0.837	0.40005	0.808	0.16968	0.504	0.33653	0.753
HUWE1	45 (9%)	465	0.00112	0.0217	0.00044	0.00939	0.40765	0.808	0.63659	0.911	0.01784	0.163	0.04285	0.254	0.17501	0.511	0.66751	0.935	0.13193	0.444	0.15729	0.489
HNRNPL	11 (2%)	499	0.47478	0.861	0.02088	0.176	0.20865	0.586	0.75785	0.969	0.59712	0.889	0.35328	0.772	0.74179	0.962	0.1292	0.444	0.75806	0.969	0.46466	0.856
ITGB1	14 (3%)	496	0.61651	0.899	0.075169	0.34	0.27823	0.682	0.61012	0.897	0.0183	0.163	0.04752	0.274	0.40344	0.808	0.11308	0.424	0.14742	0.474	0.58493	0.889
B2M	7 (1%)	503	0.19392	0.558	0.33196	0.752	NA	NA	NA	NA	0.24194	0.626	0.13682	0.449	0.072689	0.34	0.1586	0.49	1	1	0.12739	0.444
LRRC37B	16 (3%)	494	0.15245	0.485	0.32552	0.744	1	1	1	1	0.23501	0.616	0.15558	0.488	0.90068	1	0.53163	0.879	0.02745	0.211	0.56922	0.886
PPFIA4	14 (3%)	496	0.89537	1	0.58543	0.889	0.28567	0.698	0.73422	0.962	0.65829	0.926	0.53959	0.881	0.089939	0.382	0.31576	0.73	0.77266	0.975	0.63209	0.911
PIK3R1	9 (2%)	501	0.51841	0.875	0.067779	0.331	NA	NA	NA	NA	0.33268	0.752	0.13466	0.446	0.57986	0.889	0.24971	0.636	0.29599	0.704	0.39713	0.808
VPS33B	7 (1%)	503	0.10781	0.423	0.02906	0.214	0.70384	0.954	1	1	0.72425	0.962	0.33447	0.753	0.57584	0.889	0.56589	0.886	0.9693	1	0.33559	0.753
C8ORF31	4 (1%)	506	1	1	0.40644	0.808	NA	NA	NA	NA	0.38718	0.806	1	1	0.69193	0.947	1	1	0.84222	1	0.75842	0.969
NCOR1	18 (4%)	492	0.87659	1	0.090059	0.382	0.46772	0.856	0.49476	0.863	0.62211	0.901	0.17022	0.504	0.53865	0.881	0.10922	0.424	0.52494	0.877	0.85311	1
SEH1L	4 (1%)	506	0.20773	0.586	0.064479	0.326	NA	NA	NA	NA	0.30856	0.721	0.0451	0.263	0.39396	0.808	0.098049	0.4	0.15428	0.486	1	1
CUL3	14 (3%)	496	0.02026	0.173	0.00375	0.0511	0.36476	0.786	0.73119	0.962	0.33219	0.752	0.02767	0.211	0.21441	0.592	0.83994	1	0.00145	0.0244	0.37879	0.795
NOTCH2	20 (4%)	490	0.45261	0.852	0.39984	0.808	0.074959	0.34	0.34715	0.766	0.59449	0.889	0.30747	0.721	0.50226	0.863	0.48589	0.863	0.90077	1	0.59937	0.89
YTHDF1	6 (1%)	504	0.59047	0.889	0.83887	1	NA	NA	NA	NA	1	1	0.83386	1	0.5869	0.889	0.51833	0.875	0.53534	0.881	1	1
FOSL2	10 (2%)	500	0.85776	1	0.41471	0.814	0.30632	0.721	0.51072	0.872	0.16026	0.491	0.37192	0.791	0.78905	0.985	0.7804	0.98	0.11383	0.424	0.13309	0.444
MYH9	22 (4%)	488	0.01603	0.155	0.23769	0.618	0.54408	0.886	0.47008	0.857	0.55698	0.886	0.71675	0.962	0.70378	0.954	0.45429	0.852	0.84634	1	0.45549	0.852
TP63	12 (2%)	498	0.19996	0.571	0.92757	1	0.82148	1	1	1	0.49998	0.863	0.73113	0.962	0.04144	0.248	0.42724	0.834	0.78271	0.98	0.54914	0.886
DYSF	21 (4%)	489	0.88333	1	0.01856	0.163	0.13528	0.446	0.73239	0.962	0.092099	0.385	0.0166	0.156	0.24449	0.628	0.22455	0.604	0.03889	0.242	0.076379	0.342
TMEM2	17 (3%)	493	0.28935	0.701	0.075069	0.34	0.86266	1	0.15979	0.491	0.31465	0.73	0.46649	0.856	0.70229	0.954	0.51811	0.875	0.72015	0.962	0.56015	0.886
PTPN14	15 (3%)	495	0.0182	0.163	0.11914	0.434	0.84776	1	0.57792	0.889	0.22627	0.606	0.72087	0.962	0.04512	0.263	0.63781	0.911	0.26334	0.656	0.45145	0.852
RBM10	4 (1%)	506	0.45496	0.852	0.52635	0.877	NA	NA	NA	NA	0.69168	0.947	0.66703	0.935	0.69572	0.949	0.56513	0.886	0.80614	0.998	0.65394	0.922
IRF2	8 (2%)	502	0.065959	0.327	0.13014	0.444	NA	NA	NA	NA	0.02979	0.214	0.079859	0.355	0.80739	0.998	0.34941	0.768	0.43362	0.838	0.69015	0.947
AMPD1	6 (1%)	504	0.11521	0.426	0.64031	0.911	NA	NA	NA	NA	0.33884	0.753	0.17429	0.511	0.29269	0.702	0.0309	0.22	0.83714	1	0.11935	0.434
ZMYM1	9 (2%)	501	0.96142	1	0.12868	0.444	0.50581	0.866	0.54521	0.886	0.53392	0.881	0.72085	0.962	0.76109	0.97	0.83913	1	0.74255	0.962	0.63345	0.911
LCP1	15 (3%)	495	0.073849	0.34	0.089949	0.382	0.75417	0.969	0.82663	1	0.755	0.969	0.072079	0.34	0.94624	1	0.89625	1	0.73648	0.962	0.25452	0.644
SLC9A6	5 (1%)	505	0.0088299	0.103	0.093749	0.389	0.87305	1	0.11628	0.428	0.11317	0.424	0.36976	0.791	0.050109	0.284	0.23032	0.612	0.56893	0.886	0.02807	0.211
CCNG2	3 (1%)	507	0.03679	0.24	0.58635	0.889	NA	NA	NA	NA	1	1	0.74035	0.962	0.48179	0.863	1	1	NA	NA	NA	NA
TACR2	4 (1%)	506	1	1	0.86182	1	NA	NA	NA	NA	1	1	0.90371	1	1	1	0.68395	0.947	0.94513	1	1	1
