rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(5), CDC34(4), CUL1(11), RB1(18), TFDP1(3)	4986845	41	35	41	7	3	12	6	3	17	0	0.0381	0.264	1.000
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	386575	2	2	2	0	0	0	0	0	2	0	0.660	0.300	1.000
3	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2)	4644911	24	22	24	2	5	7	5	5	2	0	0.0310	0.501	1.000
4	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	549130	2	2	2	1	1	0	0	1	0	0	0.796	0.574	1.000
5	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(6)	1383171	9	9	9	2	1	3	2	2	1	0	0.347	0.623	1.000
6	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(7)	1537915	13	13	13	3	0	4	5	3	1	0	0.369	0.674	1.000
7	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(2), RAB27A(1), RAB3A(2), RAB4A(1), RAB5A(3)	3208378	14	14	14	1	5	4	2	2	1	0	0.0336	0.685	1.000
8	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(3), UGDH(4), UXS1(2)	2921501	11	11	11	0	0	1	5	4	1	0	0.104	0.695	1.000
9	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(4)	1256585	6	6	6	2	1	3	2	0	0	0	0.649	0.717	1.000
10	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(10), BCMO1(3), RDH5(1)	2966657	15	15	15	3	2	1	6	2	4	0	0.357	0.778	1.000
11	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(3), UGDH(4), UGP2(2), UXS1(2)	3720453	13	13	13	0	0	1	7	4	1	0	0.0736	0.792	1.000
12	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2)	1800404	7	7	6	2	0	1	0	3	3	0	0.747	0.810	1.000
13	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(18), SP1(3), SP3(3)	5049097	26	26	26	9	0	2	5	4	15	0	0.839	0.811	1.000
14	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(4), NR3C1(6), PPARG(1), RXRA(5)	4399391	16	16	16	1	2	4	6	2	2	0	0.0307	0.837	1.000
15	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(1), HGD(4)	1694316	7	7	7	2	1	3	2	0	1	0	0.481	0.845	1.000
16	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CHEK1(1), NEK1(9), WEE1(1)	5221484	17	17	17	1	4	3	6	1	3	0	0.124	0.864	1.000
17	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(1), GRIA2(16), JUND(1), PPP1R1B(2)	2839623	23	22	23	6	4	6	11	2	0	0	0.219	0.892	1.000
18	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(5), SNCA(1), SNCAIP(3), UBE2L3(2), UBE2L6(2)	4889898	23	21	23	4	4	5	4	7	3	0	0.155	0.912	1.000
19	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(6), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2)	2305423	12	12	11	4	0	4	4	0	4	0	0.598	0.953	1.000
20	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	1160551	1	1	1	0	0	0	0	1	0	0	0.757	0.955	1.000
21	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12A(1), IL12B(4), IL18(1), IL2(2)	2267286	12	12	12	4	1	2	2	4	3	0	0.769	0.963	1.000
22	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(4), PRKCA(7), TGM2(4)	3760452	18	18	18	4	2	6	5	3	2	0	0.114	0.965	1.000
23	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(5), CES1(7), ESD(3)	4600242	20	19	20	3	2	9	7	0	2	0	0.0470	0.972	1.000
24	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(5)	3898124	16	15	16	3	4	3	6	2	1	0	0.151	0.973	1.000
25	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	860420	1	1	1	1	0	0	1	0	0	0	0.944	0.975	1.000
26	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(2), CSAD(5), GAD1(4), GAD2(7), GGT1(4)	4376205	24	24	24	5	4	7	6	2	5	0	0.117	0.980	1.000
27	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(16), C5(11), C7(12), C8A(8), C9(15)	8096275	62	53	61	12	10	19	21	9	3	0	0.0301	0.983	1.000
28	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(12), RB1(18), WEE1(1), YWHAH(2)	12721311	65	59	65	9	7	14	14	8	22	0	0.0329	0.985	1.000
29	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(7), ELK1(2), FOS(6), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(2), PIK3R1(10), PLCG1(8), RAF1(3), SHC1(3), SOS1(9)	12509890	62	56	62	9	11	9	23	6	13	0	0.0152	0.986	1.000
30	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(2)	6634572	26	24	26	4	1	5	8	7	5	0	0.138	0.986	1.000
31	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4)	1300338	4	4	4	3	0	1	2	0	1	0	0.872	0.991	1.000
32	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(6), FOSL1(3), FOSL2(10), IFNAR1(3), IFNAR2(3), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3)	8440356	43	40	43	8	6	9	10	9	9	0	0.185	0.991	1.000
33	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1)	3683426	12	10	12	2	0	4	3	3	2	0	0.269	0.991	1.000
34	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(4), CHST12(5), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2)	7044363	40	37	40	7	10	7	11	8	4	0	0.0562	0.992	1.000
35	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1)	6032901	24	21	24	4	7	3	7	2	5	0	0.150	0.993	1.000
36	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(22), GNAS(12), GNB1(3), PRKACA(4), PRKAR1A(3)	5046187	44	37	43	8	15	7	13	6	3	0	0.0443	0.993	1.000
37	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3)	4111521	14	14	14	3	2	3	4	4	1	0	0.357	0.994	1.000
38	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(4)	4058542	23	21	23	6	2	1	11	1	8	0	0.437	0.994	1.000
39	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(2), HMGCL(1), OXCT1(2)	2569006	5	5	5	2	1	0	1	1	2	0	0.781	0.994	1.000
40	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(3), TAT(1)	1997140	5	5	5	2	0	0	3	1	1	0	0.768	0.996	1.000
41	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(3), AASS(3), KARS(3)	3583040	12	12	12	3	1	1	2	3	5	0	0.515	0.996	1.000
42	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4)	4282569	14	13	14	4	1	4	2	3	4	0	0.561	0.997	1.000
43	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(1), SPCS1(2), SPCS3(1)	2321334	6	6	6	4	0	2	1	0	3	0	0.848	0.998	1.000
44	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(3), CASP3(2), CASP9(1), GZMB(2), JUN(1), PRF1(4)	8920640	38	35	38	7	6	8	4	12	8	0	0.146	0.998	1.000
45	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(3), STX1A(6)	2472973	9	9	9	3	5	0	3	1	0	0	0.647	0.999	1.000
46	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1)	5938441	17	16	17	3	2	4	5	4	2	0	0.219	0.999	1.000
47	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4)	6158075	34	32	34	9	5	8	12	6	3	0	0.286	0.999	1.000
48	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2)	2757273	18	14	18	6	1	8	5	2	2	0	0.389	0.999	1.000
49	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(6), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(5)	4142702	22	21	21	6	4	6	6	2	4	0	0.296	0.999	1.000
50	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(1), CD80(5), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1)	3017930	15	15	14	5	0	4	4	4	3	0	0.664	0.999	1.000
51	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(5), SEC61A2(4), SRP54(2), SRP68(4), SRP72(1), SRPR(2)	5730942	18	17	18	3	2	9	6	1	0	0	0.145	0.999	1.000
52	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1)	3251066	9	9	9	3	2	5	1	1	0	0	0.406	0.999	1.000
53	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(3), CD3D(1), CD80(5), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3R1(10), PTPN11(2)	8051580	39	33	38	7	0	8	8	9	14	0	0.133	0.999	1.000
54	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(1), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PRKCA(7)	4449572	21	19	21	6	1	6	6	3	5	0	0.364	0.999	1.000
55	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(5), CDC34(4), CUL1(11), RB1(18), SKP2(4), TFDP1(3)	6468191	52	45	52	13	4	12	13	5	18	0	0.217	1.000	1.000
56	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(6), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2)	4052954	19	19	18	6	1	5	8	2	3	0	0.535	1.000	1.000
57	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(6), CD3D(1), CD4(1), CD58(2), CD8A(2), IL3(1), IL6(2), KITLG(1)	4699278	17	16	17	6	2	2	3	4	6	0	0.695	1.000	1.000
58	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2), GLUD1(4), GLUD2(10)	3468502	17	17	17	6	4	2	4	3	4	0	0.686	1.000	1.000
59	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(4), BCKDK(6), CTH(3), MUT(5)	3728828	18	17	18	5	2	6	4	3	3	0	0.473	1.000	1.000
60	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(2), IDI1(1)	2430488	7	7	7	3	2	4	1	0	0	0	0.550	1.000	1.000
61	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(8)	3576674	20	18	20	6	2	3	10	1	4	0	0.520	1.000	1.000
62	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(1)	3047233	15	14	15	5	2	3	5	2	3	0	0.600	1.000	1.000
63	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(4), IFNGR2(5), JAK1(11), JAK2(5), STAT1(7)	6222329	34	30	33	9	2	9	9	5	9	0	0.242	1.000	1.000
64	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(7), ELK1(2), FOS(6), INSR(3), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(10), PTPN11(2), RAF1(3), SHC1(3), SLC2A4(4), SOS1(9), SRF(1)	15828483	64	57	64	9	8	11	21	10	14	0	0.00614	1.000	1.000
65	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), FUT9(11), GBGT1(3), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3)	7710747	36	34	36	8	6	7	13	4	6	0	0.102	1.000	1.000
66	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(22), CREM(3), FHL5(5), FSHB(2), FSHR(12), GNAS(12), XPO1(6)	7305896	62	53	61	12	14	12	19	14	3	0	0.0687	1.000	1.000
67	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(7), SDHB(1), SDHC(1), UQCRC1(1)	5030336	17	17	16	4	1	5	6	4	1	0	0.336	1.000	1.000
68	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(3), CD3D(1), CD4(1)	2438429	5	5	5	3	0	0	1	3	1	0	0.904	1.000	1.000
69	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(3), HTR2C(3), PLCB1(21), TUB(3)	5432569	30	30	29	8	7	5	12	5	1	0	0.293	1.000	1.000
70	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1)	6350763	18	16	18	4	1	3	8	4	2	0	0.416	1.000	1.000
71	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(5), CDKN1B(3), CKS1B(4), CUL1(11), NEDD8(2), RB1(18), RBX1(3), SKP2(4), TFDP1(3), UBE2M(2)	6508770	55	51	55	14	4	13	12	6	20	0	0.202	1.000	1.000
72	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(2), FOS(6), FYN(5), JUN(1), MAPK14(2), THBS1(8)	5637356	26	24	26	7	3	7	5	7	4	0	0.239	1.000	1.000
73	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(3)	5282395	17	17	17	5	1	1	3	6	6	0	0.603	1.000	1.000
74	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(3), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3)	8183514	37	35	37	9	6	7	14	4	6	0	0.137	1.000	1.000
75	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3)	5283313	15	14	15	3	3	5	5	1	1	0	0.283	1.000	1.000
76	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3)	7766709	32	31	32	7	7	10	8	3	4	0	0.0943	1.000	1.000
77	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(22), NRG2(6), NRG3(17), PRKCA(7)	6834830	57	52	57	15	4	9	22	12	10	0	0.371	1.000	1.000
78	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(6), ST6GALNAC2(3), ST8SIA1(3)	4298913	20	19	20	7	4	4	5	2	5	0	0.426	1.000	1.000
79	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(2)	4604224	22	22	22	8	3	2	11	1	5	0	0.649	1.000	1.000
80	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(12), WEE1(1), YWHAH(2)	10453443	42	37	42	7	7	9	11	8	7	0	0.120	1.000	1.000
81	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(4), GH1(4), GHR(8), IGF1(1), IGF1R(13), PIK3R1(10), SHC1(3), SOD1(1), SOD2(1), SOD3(3)	8126349	50	43	50	11	10	12	14	9	5	0	0.0867	1.000	1.000
82	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	16	IL18(1), ITGB1(17), KLRC1(1), KLRC2(1), KLRC3(4), LAT(3), MAP2K1(5), PAK1(3), PIK3R1(10), PTK2B(4), PTPN6(3), SYK(8), VAV1(8)	11388222	68	56	67	12	14	9	15	9	21	0	0.0420	1.000	1.000
83	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT2(2), FUT9(11), GCNT2(7), ST8SIA1(3)	4694960	26	25	25	9	4	6	13	2	1	0	0.464	1.000	1.000
84	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(2), GGT1(4), SHMT1(1), SHMT2(2)	3159906	9	8	9	4	3	0	4	1	1	0	0.730	1.000	1.000
85	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6)	6560593	22	22	22	5	6	5	3	5	3	0	0.322	1.000	1.000
86	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1), GLUD1(4), OAT(1), PRODH(1)	4210897	8	8	8	3	0	2	1	3	2	0	0.659	1.000	1.000
87	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4)	10663831	47	41	47	9	11	11	13	6	6	0	0.0430	1.000	1.000
88	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3)	5041172	26	25	26	8	4	3	7	7	5	0	0.440	1.000	1.000
89	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3)	5041172	26	25	26	8	4	3	7	7	5	0	0.440	1.000	1.000
90	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(10), PDXK(1), PSAT1(1)	3686452	12	10	12	5	1	2	1	6	2	0	0.766	1.000	1.000
91	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(6), DNAJC3(2), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2)	6848557	24	23	24	9	4	5	5	3	7	0	0.753	1.000	1.000
92	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(7), ACO2(3), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1)	6763942	22	19	22	5	2	8	9	1	2	0	0.223	1.000	1.000
93	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(1), CREBBP(40), GZMA(2), GZMB(2), HMGB2(2), PRF1(4), SET(1)	8072642	53	44	52	13	10	8	13	11	10	1	0.145	1.000	1.000
94	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(10), PLCB1(21), PLCG1(8), PRKCA(7), VAV1(8)	8080811	56	50	55	13	7	9	22	8	10	0	0.228	1.000	1.000
95	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(7), ELK1(2), FOS(6), IGF1(1), IGF1R(13), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(10), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1)	15296528	71	62	71	11	12	13	22	11	13	0	0.00672	1.000	1.000
96	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(9)	7011957	32	29	32	9	6	8	10	6	2	0	0.240	1.000	1.000
97	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(16), ATR(25), CDC25C(4), CHEK1(1), CHEK2(5), YWHAH(2)	11536354	53	48	53	9	4	16	10	14	9	0	0.120	1.000	1.000
98	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(4), NRF1(5), TAX1BP3(1), UBE2D2(1), UBE2D3(1), UBE2E1(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(2), UBE2S(1), UBE3A(6)	8012959	29	27	29	8	4	11	8	0	6	0	0.326	1.000	1.000
99	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1B(4), BMPR2(6)	4760347	15	15	15	6	3	4	4	1	3	0	0.729	1.000	1.000
100	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(12), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIK(1), BIRC2(2), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), DIABLO(2)	9317945	39	35	39	8	7	13	5	6	8	0	0.113	1.000	1.000
101	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(12), BAD(2), BAK1(1), BAX(2), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(7)	8316255	33	31	33	8	7	9	6	5	6	0	0.341	1.000	1.000
102	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1)	6441487	24	21	24	6	1	4	10	7	2	0	0.383	1.000	1.000
103	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(5), ITPKB(5)	4610024	11	9	11	4	1	3	4	1	2	0	0.609	1.000	1.000
104	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C7(12), C8A(8), C9(15)	11866188	77	65	76	17	12	27	24	10	4	0	0.0217	1.000	1.000
105	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	6	CREBBP(40), LPL(4), NCOA1(7), NCOA2(8), PPARG(1), RXRA(5)	10308805	65	51	64	14	7	13	19	15	10	1	0.0953	1.000	1.000
106	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(14), RANGAP1(1)	6414010	18	18	18	9	3	4	5	1	5	0	0.941	1.000	1.000
107	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(2)	4542113	23	21	22	9	4	7	8	2	2	0	0.333	1.000	1.000
108	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	13	CUZD1(3), FOS(6), JUN(1), MAP2K1(5), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RAF1(3), RELA(2)	11000650	60	56	57	15	8	13	24	8	7	0	0.0830	1.000	1.000
109	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), IL6(2), IL6R(5), IL6ST(4), JAK1(11), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT3(6)	17770774	79	70	79	13	13	12	26	16	12	0	0.00567	1.000	1.000
110	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(5), DLL1(5), FURIN(1)	3958653	11	11	11	5	3	3	2	1	2	0	0.738	1.000	1.000
111	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6)	9796477	37	32	37	8	1	8	14	10	4	0	0.229	1.000	1.000
112	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), WT1(3)	4746761	17	17	15	7	0	4	8	3	2	0	0.770	1.000	1.000
113	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(12), ATM(16), BAX(2), BCL2(1), CCND1(4), CCNE1(5), CDK4(5), GADD45A(1), MDM2(2), PCNA(1), RB1(18)	13151754	67	60	67	13	4	17	10	13	23	0	0.105	1.000	1.000
114	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), CS(2), MDH1(1), ME1(2), PC(14), PDHA1(4)	7057566	27	27	27	8	4	7	6	5	5	0	0.331	1.000	1.000
115	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(2), CALM3(2), CCL2(2), CXCL12(6), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(8), PRKCA(7), PTK2B(4), SYT1(8)	10487659	55	49	55	13	8	9	21	13	4	0	0.105	1.000	1.000
116	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NFS1(1), PHPT1(1), TPK1(3)	4868352	16	14	16	5	4	2	5	3	2	0	0.699	1.000	1.000
117	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C7(12), C8A(8), C9(15), MASP1(9), MASP2(5), MBL2(2)	14759177	93	74	91	21	15	29	25	16	8	0	0.0178	1.000	1.000
118	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(8), MDM2(2), MYC(6), PIK3R1(10), POLR1A(10), POLR1B(4), POLR1C(3), RB1(18), TBX2(4), TWIST1(1)	12367648	66	58	63	14	6	10	13	11	26	0	0.149	1.000	1.000
119	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(4), JAK1(11), JAK2(5), PLA2G2A(2), PTPRU(9), REG1A(13), STAT1(7)	8690684	54	48	53	14	8	16	13	7	10	0	0.108	1.000	1.000
120	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(2), CASP9(1), CHUK(6), GH1(4), GHR(8), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3R1(10), RELA(2), YWHAH(2)	9069885	47	41	46	11	5	12	12	7	11	0	0.212	1.000	1.000
121	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(11), EPHB1(16), FYN(5), ITGA1(4), ITGB1(17), L1CAM(10), LYN(8), RAP1B(3), SELP(15)	12007305	93	66	91	20	13	17	25	18	20	0	0.0671	1.000	1.000
122	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), CSF1(2), IL6(2), LDLR(6), LPL(4)	4042609	16	16	15	7	2	5	6	2	1	0	0.708	1.000	1.000
123	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	13	AKT1(2), CREB1(1), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), NTRK1(3), PIK3R1(10), PLCG1(8), RPS6KA1(10), SHC1(3)	11207042	52	46	52	10	11	9	13	11	8	0	0.0766	1.000	1.000
124	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8)	9615390	56	49	54	14	4	10	18	8	16	0	0.215	1.000	1.000
125	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(5), CREB1(1), CREBBP(40), NCOA3(9), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RARA(4), RXRA(5)	11954119	80	65	79	21	15	19	16	13	16	1	0.121	1.000	1.000
126	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(3), GGT1(4), SHMT1(1), SHMT2(2)	4189992	11	11	11	5	5	2	2	1	1	0	0.639	1.000	1.000
127	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(16), GNA12(2), PRKACB(3), PRKACG(3), PRKAR2B(3)	7645574	27	25	27	8	5	10	6	3	3	0	0.393	1.000	1.000
128	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(2), IL1B(1), MST1(7), MST1R(8)	4955041	20	19	20	9	4	6	8	0	2	0	0.612	1.000	1.000
129	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(2), OXCT2(1)	5469959	13	12	13	8	3	2	2	4	2	0	0.925	1.000	1.000
130	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(8), GLI2(15), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3)	12661824	70	62	69	17	13	17	24	8	8	0	0.0678	1.000	1.000
131	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(22), ARHGEF1(9), F2(3), F2R(4), F2RL3(3), GNA12(2), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3R1(10), PLCB1(21), PPP1R12B(5), PRKCA(7), PTK2B(4), ROCK1(19)	18014302	124	100	121	26	21	24	40	23	16	0	0.00970	1.000	1.000
132	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), BCAR1(3), CDKN1B(3), ILK(4), ITGB1(17), PDK2(1), PDPK1(4), PIK3R1(10), PTK2(10), SHC1(3), SOS1(9)	11921381	66	56	64	15	9	13	17	9	18	0	0.169	1.000	1.000
133	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	19	F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), ITGA1(4), ITGB1(17), MAP2K1(5), PLA2G4A(3), PLCB1(21), PRKCA(7), PTGS1(7), PTK2(10), RAF1(3), SYK(8), TBXAS1(5)	17698435	105	86	103	22	15	18	33	20	19	0	0.0219	1.000	1.000
134	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(4)	6989177	25	24	25	8	6	7	6	2	4	0	0.397	1.000	1.000
135	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(5), ST3GAL4(1)	5501975	18	17	18	7	5	2	7	2	2	0	0.694	1.000	1.000
136	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(27), CDH1(5), CREBBP(40), MAP2K1(5), MAP3K7(8), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2)	14883936	96	73	93	20	11	15	29	21	19	1	0.138	1.000	1.000
137	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(4), MPST(2)	5208192	19	17	19	7	4	1	11	2	1	0	0.707	1.000	1.000
138	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST7(2), CHSY1(3), DSE(2), UST(3), XYLT1(10), XYLT2(3)	10680334	56	51	56	12	14	5	19	11	7	0	0.0687	1.000	1.000
139	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(7), ELK1(2), EPO(2), EPOR(2), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(8), PTPN6(3), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5)	15986399	68	61	68	13	13	18	24	4	9	0	0.0109	1.000	1.000
140	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), BRAF(10), CREB1(1), CREB3(1), CREB5(8), RAF1(3), SNX13(2)	7952573	26	20	26	9	2	4	8	6	6	0	0.697	1.000	1.000
141	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(12), GNB1(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7)	7309401	40	35	40	10	14	9	9	4	4	0	0.184	1.000	1.000
142	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1)	5573878	15	15	15	7	2	2	6	4	1	0	0.881	1.000	1.000
143	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), IMPA2(4), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3)	8868988	40	38	40	10	9	11	10	3	7	0	0.0806	1.000	1.000
144	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(7), CCNA2(4), CCND1(4), CCNE1(5), CCNE2(4), CDK4(5), CDKN1B(3), E2F2(3), E2F4(2), PRB1(8)	6397211	45	43	45	14	1	12	13	12	7	0	0.572	1.000	1.000
145	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	5	CREBBP(40), ESR1(6), PELP1(2)	6952436	48	40	47	15	5	7	14	10	11	1	0.419	1.000	1.000
146	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(4)	6469482	24	24	24	9	4	3	6	8	3	0	0.624	1.000	1.000
147	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(12), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3R1(10), RELA(2), SYT1(8)	11981750	62	50	62	13	13	12	14	12	11	0	0.111	1.000	1.000
148	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(3), C1R(4), C1S(6), C2(2), C3(16), C5(11), C7(12), C8A(8), C8B(9), C9(15), MASP1(9)	14372980	95	77	93	24	15	28	29	15	8	0	0.0540	1.000	1.000
149	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(2), CAMKK2(6), CREB1(1), SYT1(8)	8786689	37	37	37	10	5	7	13	8	4	0	0.366	1.000	1.000
150	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	17	AKT1(2), BAD(2), BCL2L1(2), CASP9(1), CDC42(4), CHUK(6), ELK1(2), H2AFX(1), MAP2K1(5), NFKB1(5), PIK3R1(10), RAF1(3), RALBP1(5), RALGDS(9), RELA(2)	11885461	59	50	59	14	13	11	18	4	13	0	0.146	1.000	1.000
151	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA3(2), ANXA4(2), ANXA6(7), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(4), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5)	15681651	80	68	79	20	18	13	17	13	18	1	0.0720	1.000	1.000
152	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(5), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(4)	5738999	15	15	15	8	1	3	5	5	1	0	0.913	1.000	1.000
153	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(9), EGFR(21), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(24), RARA(4), RXRA(5), THRA(7), THRB(1)	13131412	84	69	84	22	13	14	24	18	14	1	0.139	1.000	1.000
154	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(1), PTK2B(4), SHC1(3), SOS1(9)	6371114	17	16	17	7	7	2	4	3	1	0	0.710	1.000	1.000
155	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	12	AKT1(2), BAD(2), IGF1R(13), IRS1(4), MAP2K1(5), PIK3R1(10), RAF1(3), SHC1(3), SOS1(9), YWHAH(2)	11923445	53	45	53	13	10	12	16	8	7	0	0.142	1.000	1.000
156	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4)	11404505	49	45	49	13	10	13	11	8	7	0	0.143	1.000	1.000
157	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	19	CSNK2A1(7), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), THPO(1)	19237986	90	75	90	19	14	22	27	10	17	0	0.0217	1.000	1.000
158	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(5), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(1), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5)	11454795	52	49	52	14	10	10	15	5	12	0	0.0625	1.000	1.000
159	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTA1(4), ACTN1(6), ACTN2(11), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(17), ITGB3(8), PTK2(10), PXN(3), SPTAN1(24), TLN1(24)	21398474	118	94	117	23	20	19	44	20	15	0	0.00802	1.000	1.000
160	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(1), DAB1(8), FYN(5), LRP8(4), RELN(53), VLDLR(5)	10640095	79	65	79	23	14	16	19	16	14	0	0.233	1.000	1.000
161	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(5), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(4)	8140743	38	34	38	11	5	7	9	12	5	0	0.513	1.000	1.000
162	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F2(3), F2R(4), F3(2), F5(20), F7(3), FGA(10), FGB(4), FGG(6), PROC(2), PROS1(9), SERPINC1(4), TFPI(2)	12450168	73	58	73	19	6	23	21	13	10	0	0.158	1.000	1.000
163	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(1), FARSB(7), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7), YARS2(4)	6612485	35	32	35	10	2	11	12	5	5	0	0.260	1.000	1.000
164	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4)	7051136	31	30	31	10	7	9	5	4	6	0	0.355	1.000	1.000
165	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6)	10251772	47	40	47	11	3	9	18	6	11	0	0.193	1.000	1.000
166	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	20	ACTA1(4), ADCY1(22), CAP1(6), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(12), GNB1(3), MYT1(12), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10)	14810434	95	75	94	22	28	19	24	14	10	0	0.0209	1.000	1.000
167	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(12), BIRC2(2), BIRC3(2), CASP10(3), CASP3(2), CASP7(3), CASP9(1), GZMB(2), PRF1(4), SCAP(9), SREBF1(5), SREBF2(5)	12953721	50	45	50	12	10	11	10	10	9	0	0.146	1.000	1.000
168	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(5), APC(27), AXIN1(11), BTRC(1), CTNNB1(6), DLL1(5), DVL1(7), FZD1(6), GSK3B(3), WNT1(2)	13236379	73	53	72	19	13	18	16	13	12	1	0.154	1.000	1.000
169	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(3), CDKN2C(1), RB1(18), RBL1(11), TFDP1(3)	11744055	66	60	66	18	4	14	14	11	23	0	0.283	1.000	1.000
170	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(2), IL12A(1), IL12B(4), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4)	7559330	36	34	36	12	7	9	10	6	4	0	0.460	1.000	1.000
171	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(11), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(9), REG1A(13), SOAT1(5)	10403694	55	51	55	15	10	10	17	9	9	0	0.246	1.000	1.000
172	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(6), MBTPS1(10), MBTPS2(4), SCAP(9), SREBF1(5), SREBF2(5)	9048536	42	40	41	13	6	8	13	10	5	0	0.439	1.000	1.000
173	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(40), FYN(5), IL7(1), IL7R(6), JAK1(11), JAK3(6), LCK(5), NMI(6), PIK3R1(10), PTK2B(4), STAT5A(3), STAT5B(5)	15834955	103	78	102	27	10	22	24	22	24	1	0.0533	1.000	1.000
174	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(8), FOS(6), IL3(1), IL3RA(6), JAK2(5), MAP2K1(5), PTPN6(3), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5)	13118426	57	50	57	15	9	17	17	8	6	0	0.0953	1.000	1.000
175	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(7), ELK1(2), FOS(6), IL2(2), IL2RA(2), IL2RB(3), JAK1(11), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5), SYK(8)	17382445	85	72	85	21	11	18	28	11	17	0	0.0443	1.000	1.000
176	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(5), JAK1(11), JAK2(5), JAK3(6), PIAS3(4), PTPRU(9), REG1A(13), STAT3(6)	11553078	62	58	62	17	11	11	20	12	8	0	0.171	1.000	1.000
177	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(6), CREBBP(40), FADD(4), HDAC3(3), IKBKB(12), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3)	13310411	82	72	81	22	12	15	24	16	14	1	0.159	1.000	1.000
178	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(8), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(13), HIF1A(3), KDR(13), NOS3(4), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(10), PXN(3), SHC1(3)	23822343	132	107	132	29	26	33	33	20	20	0	0.0176	1.000	1.000
179	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(5), HDAC5(3), MEF2A(3), MEF2B(5), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(4), SYT1(8), YWHAH(2)	14716358	56	50	55	14	5	15	19	14	3	0	0.112	1.000	1.000
180	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), KLK2(2), NTRK1(3), PIK3R1(10), PLCG1(8), PRKCA(7), SHC1(3), SOS1(9)	9840505	44	40	44	12	7	10	14	7	6	0	0.350	1.000	1.000
181	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	22	ADCY1(22), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(12), MAPK14(2), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RPS6KA1(10), RPS6KA5(5), SOS1(9)	19336048	107	88	106	25	22	25	29	14	17	0	0.0396	1.000	1.000
182	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	18	AKT1(2), CCND1(4), CCNE1(5), CDK4(5), CDK6(2), CDKN1B(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3R1(10), RAF1(3), RB1(18), RELA(2), TFDP1(3)	12559647	66	62	66	18	4	12	14	8	28	0	0.290	1.000	1.000
183	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(2), EGF(9), EGFR(21), MET(4), PDGFRA(14), PRKCA(7), SH3GLB1(2), SH3GLB2(3), SH3KBP1(8)	14746309	73	67	73	21	9	16	23	13	11	1	0.208	1.000	1.000
184	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), ARHGAP5(10), BAD(2), BCAR1(3), BCL2(1), BIRC2(2), BIRC3(2), BRAF(10), CAPN2(6), CAV1(1), CCND1(4), CCND2(2), CDC42(4), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(9), EGFR(21), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(23), FLNB(10), FLNC(15), FLT1(17), FN1(19), FYN(5), GSK3B(3), HGF(13), IBSP(3), IGF1(1), IGF1R(13), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(17), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), JUN(1), KDR(13), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), MAP2K1(5), MAPK10(4), MAPK8(4), MAPK9(5), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), MYLPF(2), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PDPK1(4), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(14), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(53), ROCK1(19), ROCK2(10), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TLN1(24), TLN2(13), TNC(12), TNN(23), TNR(19), TNXB(23), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2)	277078767	1494	416	1481	478	236	322	474	230	226	6	0.0486	1.000	1.000
185	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY7(5), ADCY8(28), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ATP2A1(8), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(16), ATP2B4(6), AVPR1A(9), AVPR1B(7), BDKRB1(3), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(13), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(6), CD38(5), CHRM2(5), CHRM3(9), CHRM5(3), CHRNA7(2), CYSLTR1(2), CYSLTR2(5), DRD1(2), EDNRA(2), EDNRB(7), EGFR(21), ERBB2(11), ERBB3(14), ERBB4(22), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(12), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(30), GRM5(13), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), LHCGR(9), LTB4R2(3), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(14), PDGFRB(8), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), PTGER3(7), PTGFR(2), PTK2B(4), RYR1(34), RYR2(79), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(17), SPHK2(5), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), TNNC2(1), TRHR(7), TRPC1(10)	204129430	1231	395	1224	426	259	262	355	203	151	1	0.00576	1.000	1.000
186	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	240	ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(4), AKT3(6), ARRB1(2), ARRB2(3), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(13), CACNA1S(16), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(5), CACNB2(7), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(4), CACNG6(5), CACNG7(4), CACNG8(8), CASP3(2), CD14(1), CDC25B(4), CDC42(4), CHUK(6), CRK(2), CRKL(3), DAXX(5), DDIT3(1), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(4), EGF(9), EGFR(21), ELK1(2), ELK4(4), FAS(5), FASLG(1), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(4), FGFR2(3), FGFR3(15), FGFR4(6), FLNA(23), FLNB(10), FLNC(15), FOS(6), GADD45A(1), GADD45G(1), GNA12(2), GNG12(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MAPKAPK3(4), MAPKAPK5(2), MAPT(9), MAX(1), MKNK1(1), MKNK2(3), MOS(7), MYC(6), NF1(16), NFATC2(15), NFATC4(4), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(14), PDGFRB(8), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP3R2(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), PTPN5(1), PTPN7(5), PTPRR(5), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(8), RASGRP4(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(1), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(1), TAOK1(6), TAOK2(16), TAOK3(5), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TNFRSF1A(1), TRAF2(2), TRAF6(3), ZAK(5)	212444297	1105	389	1094	362	218	235	323	165	162	2	0.0172	1.000	1.000
187	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(7), ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(4), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(6), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CNR1(4), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(5), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHB(2), FSHR(12), GABBR1(3), GABBR2(6), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GABRB1(8), GABRB2(8), GABRB3(15), GABRD(2), GABRE(8), GABRG1(10), GABRG2(8), GABRG3(8), GABRP(6), GABRQ(10), GABRR1(4), GABRR2(4), GALR1(4), GALR2(4), GALR3(2), GH1(4), GH2(7), GHR(8), GHRHR(4), GHSR(3), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(3), GLRA2(5), GLRA3(4), GLRB(4), GNRHR(3), GPR156(5), GPR35(2), GPR50(6), GPR63(6), GPR83(1), GRIA1(17), GRIA2(16), GRIA3(8), GRIA4(12), GRID1(20), GRID2(21), GRIK1(8), GRIK2(15), GRIK3(8), GRIK4(6), GRIK5(9), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(30), GRM2(10), GRM3(32), GRM4(2), GRM5(13), GRM6(4), GRM7(19), GRM8(23), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), LEP(1), LEPR(20), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(3), MAS1(2), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), MCHR1(3), MCHR2(5), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR1(1), NPBWR2(4), NPY1R(6), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX7(1), P2RY1(5), P2RY10(5), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), P2RY8(3), PARD3(15), PRL(4), PRLHR(5), PRLR(8), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(7), PTGER4(6), PTGFR(2), PTGIR(2), PTH2R(12), RXFP1(5), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), THRA(7), THRB(1), TRHR(7), TRPV1(7), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(6)	167011664	1236	384	1229	436	225	231	424	201	154	1	0.0184	1.000	1.000
188	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	197	ABI2(3), ACTN1(6), ACTN2(11), ACTN4(6), APC(27), APC2(6), ARAF(2), ARHGEF1(9), ARHGEF12(12), ARHGEF4(5), ARHGEF6(7), ARHGEF7(3), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(3), BCAR1(3), BDKRB1(3), BDKRB2(3), BRAF(10), CD14(1), CDC42(4), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CRK(2), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(9), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(9), EGFR(21), F2(3), F2R(4), FGD1(12), FGD3(5), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(4), FGFR2(3), FGFR3(15), FGFR4(6), FN1(19), GIT1(5), GNA12(2), GNA13(2), GNG12(1), GSN(5), IQGAP1(11), IQGAP2(6), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(17), ITGB2(4), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(7), MAP2K1(5), MAP2K2(6), MOS(7), MSN(3), MYH10(23), MYH14(7), MYH9(24), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), MYLPF(2), NCKAP1(8), NCKAP1L(8), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(14), PDGFRB(8), PFN1(1), PFN4(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(3), RDX(1), ROCK1(19), ROCK2(10), RRAS(2), RRAS2(1), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(7), SSH2(7), SSH3(5), TIAM1(15), TIAM2(13), TMSB4Y(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), WAS(2), WASF1(3), WASF2(5), WASL(2)	205275484	1008	369	996	345	188	206	292	164	156	2	0.303	1.000	1.000
189	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(5), ACTG1(3), CHAD(5), COL11A1(65), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(9), DSG2(3), DSG3(2), DSG4(5), FN1(19), GJA1(2), GJA10(7), GJA3(2), GJA4(1), GJA5(6), GJA8(8), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(3), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(11), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(4), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(5), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(4), KRT35(4), KRT36(6), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(3), KRT72(4), KRT73(4), KRT74(7), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(4), KRT8(1), KRT82(7), KRT83(6), KRT84(1), KRT85(5), KRT86(4), KRT9(3), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), LMNA(1), LMNB1(1), LMNB2(8), NES(13), RELN(53), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VIM(4), VTN(2), VWF(19)	189768350	1052	361	1046	364	175	214	355	150	153	5	0.393	1.000	1.000
190	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	120	ABL1(8), ABLIM1(8), ABLIM2(5), ABLIM3(5), ARHGEF12(12), CDC42(4), CDK5(3), CFL1(2), CXCL12(6), CXCR4(2), DCC(31), DPYSL2(5), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA3(20), EPHA4(11), EPHA5(25), EPHA6(18), EPHA7(24), EPHA8(5), EPHB1(16), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(6), FYN(5), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), ITGB1(17), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(7), LRRC4C(29), MET(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLXNA1(24), PLXNA2(17), PLXNA3(15), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTK2(10), RAC2(2), RAC3(3), RGS3(10), RHOD(1), ROBO1(13), ROBO2(16), ROBO3(6), ROCK1(19), ROCK2(10), SEMA3A(14), SEMA3C(8), SEMA3D(5), SEMA3E(12), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(4), SEMA4C(3), SEMA4D(8), SEMA4F(5), SEMA4G(8), SEMA5B(13), SEMA6A(3), SEMA6B(6), SEMA6C(1), SEMA6D(11), SEMA7A(4), SLIT1(9), SLIT2(25), SLIT3(9), SRGAP1(11), SRGAP2(2), SRGAP3(7), UNC5A(5), UNC5B(8), UNC5C(20), UNC5D(22)	143666998	891	357	884	280	138	184	279	153	135	2	0.0195	1.000	1.000
191	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(9), CD36(2), CD44(3), CD47(1), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(6), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DAG1(5), FN1(19), FNDC1(13), FNDC3A(11), FNDC4(3), FNDC5(1), GP5(4), GP6(3), GP9(2), HMMR(2), HSPG2(23), IBSP(3), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(17), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(5), LAMC3(9), RELN(53), SDC1(2), SDC2(2), SDC3(3), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VTN(2), VWF(19)	169148130	936	348	930	319	151	204	296	141	140	4	0.380	1.000	1.000
192	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(7), ARRB1(2), ARRB2(3), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(16), CACNA1A(14), CACNA1B(14), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(16), CACNB1(5), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(2), GNAZ(7), GNB1(3), GNB2(4), GNB3(7), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), ITPR1(16), ITPR2(26), ITPR3(10), KCNB1(3), KCNJ3(11), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(8), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(6), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(17), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3)	142455442	863	346	858	302	180	197	234	139	111	2	0.0237	1.000	1.000
193	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), AMOTL1(5), ASH1L(20), CASK(4), CDC42(4), CDK4(5), CGN(5), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTTN(12), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(24), EXOC3(3), EXOC4(15), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(2), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(14), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(7), MYH1(22), MYH10(23), MYH11(11), MYH13(28), MYH14(7), MYH15(14), MYH2(28), MYH3(14), MYH4(19), MYH6(20), MYH7(16), MYH7B(10), MYH8(26), MYH9(24), MYL7(2), MYL9(4), MYLPF(2), NRAS(1), OCLN(1), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP2R3A(14), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), RAB13(2), RRAS(2), RRAS2(1), SPTAN1(24), SYMPK(7), TJAP1(4), TJP1(12), TJP2(5), TJP3(6), VAPA(2), YES1(3), ZAK(5)	146368196	838	337	826	258	144	186	258	132	116	2	0.0138	1.000	1.000
194	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(3), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADM(1), ARRB1(2), ARRB2(3), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(6), CACNB3(3), CALCA(3), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CREB3(1), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(9), GJA1(2), GNB1(3), GNB2(4), GNB3(7), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), GSTO1(2), GUCA2A(1), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(16), ITPR2(26), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(2), PDE4B(9), PDE4D(10), PKIG(1), PLCB3(8), PLCD1(4), PLCG1(8), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(6), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(23), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3)	131546288	757	332	754	265	141	186	212	120	96	2	0.0731	1.000	1.000
195	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(5), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(2), CCL3(1), CCL8(3), CCR1(1), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(5), CNTFR(1), CRLF2(4), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(8), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCL1(3), CXCL10(2), CXCL12(6), CXCL13(1), CXCL14(1), CXCL16(3), CXCL2(1), CXCL3(1), CXCL5(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(4), EDA2R(1), EDAR(2), EGF(9), EGFR(21), EPO(2), EPOR(2), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(13), GDF5(4), GH1(4), GH2(7), GHR(8), HGF(13), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(6), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(11), INHBA(4), INHBB(4), INHBC(3), INHBE(1), KDR(13), KIT(11), KITLG(1), LEP(1), LEPR(20), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(2), OSMR(5), PDGFB(1), PDGFC(3), PDGFRA(14), PDGFRB(8), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(4), PRLR(8), RELT(5), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(2), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(11), TSLP(1), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3)	133839974	691	309	687	226	105	135	226	124	100	1	0.169	1.000	1.000
196	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADK(2), ADSL(5), ADSS(4), ADSSL1(6), AK1(1), AK2(1), AK5(12), AK7(2), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(6), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(7), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(1), GART(4), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(3), ITPA(4), NME2(1), NME4(2), NME6(1), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE11A(3), PDE1A(6), PDE1C(14), PDE2A(4), PDE3B(4), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE5A(9), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PDE9A(3), PFAS(13), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(6)	122900958	616	300	613	199	108	132	185	101	90	0	0.127	1.000	1.000
197	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(27), APC2(6), AXIN1(11), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(4), CCND2(2), CER1(1), CHD8(16), CREBBP(40), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTBP1(2), CTBP2(8), CTNNB1(6), CUL1(11), CXXC4(4), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(7), DVL2(1), DVL3(9), FBXW11(3), FOSL1(3), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(6), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(5), MMP7(1), MYC(6), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NKD1(8), NKD2(3), NLK(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PORCN(2), PPARD(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAC2(2), RAC3(3), RBX1(3), ROCK1(19), ROCK2(10), SENP2(3), SFRP1(4), SFRP4(12), SFRP5(1), SIAH1(5), SKP1(1), SMAD2(4), SMAD3(4), SOX17(3), TBL1X(6), TBL1XR1(5), TBL1Y(3), TCF7(3), TCF7L1(2), TCF7L2(1), VANGL1(2), VANGL2(5), WIF1(1), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3)	117179899	663	298	657	203	111	142	198	109	101	2	0.0152	1.000	1.000
198	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(3), ACTN2(11), ACTN4(6), DES(3), DMD(53), MYBPC1(13), MYBPC2(8), MYBPC3(5), MYH3(14), MYH6(20), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(42), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(4), TNNT3(3), TPM1(2), TPM2(2), TPM4(1), TTN(434), VIM(4)	103717356	706	297	700	198	93	180	252	105	70	6	0.109	1.000	1.000
199	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(7), CADM1(4), CADM3(5), CD2(1), CD22(3), CD226(5), CD274(1), CD276(1), CD28(3), CD34(6), CD4(1), CD40(7), CD40LG(5), CD58(2), CD6(1), CD80(5), CD86(2), CD8A(2), CD8B(2), CD99(1), CDH1(5), CDH15(3), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(11), CNTN2(8), CNTNAP1(9), CNTNAP2(27), CTLA4(2), ESAM(4), F11R(3), GLG1(4), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(13), ITGA6(4), ITGA9(3), ITGAL(7), ITGAM(8), ITGAV(6), ITGB1(17), ITGB2(4), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(4), NCAM2(13), NEGR1(7), NEO1(4), NFASC(6), NLGN1(19), NLGN2(6), NLGN3(3), NRCAM(14), NRXN1(31), NRXN2(10), NRXN3(24), OCLN(1), PDCD1(2), PTPRC(19), PTPRF(17), PTPRM(25), PVR(5), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(3), SDC4(1), SELE(7), SELL(2), SELP(15), SELPLG(1), SIGLEC1(13), SPN(3), VCAM1(10), VCAN(32)	109550739	643	288	636	237	101	135	185	116	106	0	0.525	1.000	1.000
200	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(9), EGFR(21), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(12), GRM1(30), GRM5(13), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HTR2A(5), HTR2B(2), HTR2C(3), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(1), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKG1(8), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), TJP1(12), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2)	99622820	594	286	588	175	111	134	173	109	66	1	0.000849	1.000	1.000
201	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(4), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(4), CCND2(2), CISH(1), CNTFR(1), CREBBP(40), CRLF2(4), CSF2RA(1), CSF2RB(8), CSF3R(3), EPO(2), EPOR(2), GH1(4), GH2(7), GHR(8), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL13RA2(4), IL19(4), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(11), IRF9(4), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(5), PIAS1(1), PIAS2(3), PIAS3(4), PIAS4(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIM1(3), PRL(4), PRLR(8), PTPN11(2), PTPN6(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(7), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(7), STAT2(6), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(11), TSLP(1), TYK2(8)	105156382	564	285	556	170	73	122	174	111	83	1	0.0458	1.000	1.000
202	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(4), CGA(1), EGFR(21), ELK1(2), FSHB(2), GNA11(4), GNAS(12), GNRHR(3), ITPR1(16), ITPR2(26), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(5), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLD1(17), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11)	95661740	545	285	539	177	108	126	153	94	64	0	0.0178	1.000	1.000
203	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(6), CCR1(1), CCR10(2), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(8), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(6), GPR6(5), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7), LHCGR(9), LTB4R(3), MAS1(2), MC1R(2), MC3R(4), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(8), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(2), P2RY1(5), P2RY10(5), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), RGR(4), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SUCNR1(1), TBXA2R(1), TRHR(7)	92000845	572	283	569	226	116	120	191	90	55	0	0.0823	1.000	1.000
204	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(16), ACACB(20), AKT1(2), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(4), FOXO1(3), G6PC(2), G6PC2(7), GCK(4), GSK3B(3), GYS1(7), GYS2(7), IKBKB(12), INPP5D(10), INSR(3), IRS1(4), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK10(4), MAPK8(4), MAPK9(5), MKNK1(1), MKNK2(3), NRAS(1), PCK1(1), PCK2(4), PDE3A(18), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(13), PPP1R3B(3), PPP1R3C(2), PPP1R3D(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAG3(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(17), PYGB(5), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(5), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(5), TSC2(8)	119336369	577	282	572	190	117	116	161	96	87	0	0.118	1.000	1.000
205	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), AKAP1(8), AKAP10(5), AKAP11(8), AKAP12(13), AKAP2(1), AKAP3(8), AKAP4(11), AKAP5(3), AKAP6(27), AKAP7(5), AKAP8(4), AKAP9(30), ARHGEF1(9), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(2), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(2), GNAZ(7), GNB1(3), GNB2(4), GNB3(7), GNB5(2), GNG10(1), GNG12(1), GNG13(2), IL18BP(1), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PLCB3(8), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RRAS(2), SLC9A1(4), USP5(5)	88186925	530	279	526	140	107	125	138	87	73	0	0.000121	1.000	1.000
206	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADK(2), ADSL(5), ADSS(4), AK1(1), AK2(1), AK5(12), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(6), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(4), GDA(7), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(3), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(9), PDE4C(4), PDE4D(10), PDE5A(9), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(13), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(1), RRM2(1)	97524512	517	274	514	158	88	111	167	76	75	0	0.0370	1.000	1.000
207	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(6), ACTN2(11), ACTN4(6), ARHGAP5(10), BCAR1(3), CD99(1), CDC42(4), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTNND1(8), CXCL12(6), CXCR4(2), CYBB(3), ESAM(4), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(17), ITGB2(4), ITK(3), JAM2(2), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), MYLPF(2), NCF1(2), NCF2(6), NCF4(3), NOX1(6), NOX3(8), OCLN(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(10), PTK2B(4), PTPN11(2), PXN(3), RAC2(2), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOH(1), ROCK1(19), ROCK2(10), SIPA1(3), THY1(2), TXK(5), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCAM1(10), VCL(6)	92316933	506	264	499	166	87	94	139	93	92	1	0.259	1.000	1.000
208	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	69	ACP1(1), ACTB(5), ACTG1(3), ACTN1(6), ACTN2(11), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(3), CDC42(4), CDH1(5), CREBBP(40), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(13), CTNNB1(6), CTNND1(8), EGFR(21), ERBB2(11), FARP2(3), FER(6), FGFR1(4), FYN(5), IGF1R(13), INSR(3), IQGAP1(11), LEF1(6), LMO7(8), MAP3K7(8), MET(4), MLLT4(13), NLK(1), PARD3(15), PTPN1(3), PTPN6(3), PTPRB(24), PTPRF(17), PTPRJ(7), PTPRM(25), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(3), RAC2(2), RAC3(3), SMAD2(4), SMAD3(4), SNAI2(1), SORBS1(7), SSX2IP(6), TCF7(3), TCF7L1(2), TCF7L2(1), TGFBR1(2), TJP1(12), VCL(6), WAS(2), WASF1(3), WASF2(5), WASF3(7), WASL(2), YES1(3)	84358819	477	263	471	148	75	98	137	90	75	2	0.201	1.000	1.000
209	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(22), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(1), CREB3L1(4), CREB3L2(3), CREB3L3(10), CREB3L4(2), CREBBP(40), CTNNB1(6), DCT(4), DVL1(7), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(2), GNAS(12), GSK3B(3), KIT(11), KITLG(1), KRAS(1), LEF1(6), MAP2K1(5), MAP2K2(6), MC1R(2), MITF(7), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), POMC(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), TCF7(3), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3)	78415402	480	262	475	146	105	90	135	85	63	2	0.00261	1.000	1.000
210	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(22), ADCY8(28), ARAF(2), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(40), GRIA1(17), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRM1(30), GRM5(13), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP1CA(1), PPP1R12A(5), PPP1R1A(2), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8)	70906136	488	257	483	163	83	111	136	97	60	1	0.0591	1.000	1.000
211	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(8), ABL2(11), AKT1(2), AKT2(4), AKT3(6), ARAF(2), BAD(2), BRAF(10), BTC(3), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(3), CRK(2), CRKL(3), EGF(9), EGFR(21), EIF4EBP1(1), ELK1(2), ERBB2(11), ERBB3(14), ERBB4(22), EREG(1), GAB1(5), GSK3B(3), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK9(5), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(4), NRG2(6), NRG3(17), NRG4(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(10), RAF1(3), RPS6KB1(5), RPS6KB2(2), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), STAT5A(3), STAT5B(5)	75815462	446	254	440	139	61	93	147	86	58	1	0.211	1.000	1.000
212	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(10), INPP5E(1), INPPL1(9), ITPK1(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), OCRL(4), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3C3(5), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PRKCA(7), PRKCG(14), PTPMT1(2), SYNJ1(10), SYNJ2(9)	92234964	478	251	471	143	76	101	129	92	80	0	0.0196	1.000	1.000
213	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(2), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(2), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(2), GNAS(12), GNAZ(7), GRIA1(17), GRIA2(16), GRIA3(8), GRID2(21), GRM1(30), GRM5(13), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), IGF1(1), IGF1R(13), ITPR1(16), ITPR2(26), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PRKCA(7), PRKCG(14), PRKG1(8), PRKG2(2), RAF1(3), RYR1(34)	82750691	489	250	487	153	90	101	146	92	60	0	0.0530	1.000	1.000
214	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(5), ACVRL1(4), AKT1(2), AURKB(3), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(1), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(8), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MAP3K10(6), MOS(7), NEK1(9), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9), PLK3(6), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(8), RAF1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KB1(5), STK11(7), TGFBR1(2), VRK1(1)	84052961	463	248	456	137	83	86	142	75	77	0	0.0337	1.000	1.000
215	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2A(3), AMY2B(9), ASCC3(13), ATP13A2(3), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(4), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(7), GAA(3), GANC(6), GBA(3), GCK(4), GPI(3), GUSB(5), GYS1(7), GYS2(7), HK1(4), HK2(5), HK3(8), IFIH1(6), MGAM(37), MOV10L1(6), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SI(61), SKIV2L2(4), SMARCA2(13), SMARCA5(2), TREH(1), UGDH(4), UGP2(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), UXS1(2)	94008768	473	247	471	145	56	95	154	95	71	2	0.309	1.000	1.000
216	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(17), ABCA10(13), ABCA12(19), ABCA13(39), ABCA2(17), ABCA3(10), ABCA4(15), ABCA5(6), ABCA6(11), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(20), ABCB11(9), ABCB4(13), ABCB5(12), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(9), ABCC12(11), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(9), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(9), ABCG8(13), CFTR(14), TAP1(6), TAP2(6)	89789433	441	247	439	143	65	93	133	70	80	0	0.0709	1.000	1.000
217	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(2), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FCGR3B(5), FYN(5), GZMB(2), HLA-C(5), HLA-E(1), HLA-G(2), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IFNG(2), IFNGR1(4), IFNGR2(5), ITGAL(7), ITGB2(4), KIR2DL1(6), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KLRC1(1), KLRC2(1), KLRC3(4), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MICB(3), NCR1(6), NCR2(3), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NRAS(1), PAK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRF1(4), PRKCA(7), PRKCG(14), PTK2B(4), PTPN11(2), PTPN6(3), RAC2(2), RAC3(3), RAF1(3), SH2D1B(2), SH3BP2(4), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(8), VAV2(4), VAV3(4), ZAP70(2)	82247418	433	244	427	140	86	83	119	70	75	0	0.122	1.000	1.000
218	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(8), ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(25), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(4), CDC26(1), CDC27(8), CDC6(2), CDC7(1), CDK4(5), CDK6(2), CDKN1B(3), CDKN2C(1), CHEK1(1), CHEK2(5), CREBBP(40), CUL1(11), DBF4(3), E2F2(3), E2F3(3), ESPL1(10), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(18), RBL1(11), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMC1A(3), SMC1B(7), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), WEE1(1), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	97716577	411	239	409	133	40	100	103	87	80	1	0.522	1.000	1.000
219	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(4), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(5), CD8A(2), CD8B(2), CDC42(4), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(5), GRAP2(2), ICOS(1), IFNG(2), IKBKB(12), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDCD1(2), PDK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCQ(8), PTPN6(3), PTPRC(19), RASGRP1(8), SOS1(9), SOS2(11), TEC(2), VAV1(8), VAV2(4), VAV3(4), ZAP70(2)	74997338	390	238	388	126	66	75	112	68	69	0	0.338	1.000	1.000
220	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(4), CAPN11(2), CAPN2(6), CAPN3(5), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(4), CAPNS1(2), CAV1(1), CDC42(4), CRK(2), CSK(1), DOCK1(15), FYN(5), GIT2(3), ILK(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(17), ITGB2(4), ITGB3(8), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(8), MAPK6(3), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(10), SDCCAG8(7), SEPP1(3), SHC1(3), SHC3(6), SORBS1(7), SOS1(9), TLN1(24), TNS1(8), VASP(1), VAV2(4), VAV3(4), VCL(6), ZYX(2)	99922567	461	235	456	152	78	100	137	72	74	0	0.126	1.000	1.000
221	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(2), AKT2(4), AKT3(6), CCL3(1), CD14(1), CD40(7), CD80(5), CD86(2), CHUK(6), CXCL10(2), CXCL9(3), FADD(4), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(3), IKBKB(12), IKBKE(5), IL12A(1), IL12B(4), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(3), IRF5(3), IRF7(3), JUN(1), LBP(8), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), RELA(2), RIPK1(2), SPP1(2), STAT1(7), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(3), TLR3(2), TLR4(16), TLR5(4), TLR6(4), TLR7(8), TLR8(7), TLR9(7), TOLLIP(2), TRAF3(6), TRAF6(3)	64937456	347	221	344	116	56	75	105	55	56	0	0.204	1.000	1.000
222	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(6), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), ALG9(3), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(3), CHPF(7), CHST1(4), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST2(5), CHST4(4), CHST6(8), CHST7(2), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(5), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GANAB(3), GCNT1(1), GCNT3(1), GCNT4(3), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1), ST6GAL1(3), ST6GALNAC1(4), STT3B(2), UST(3), WBSCR17(9), XYLT1(10), XYLT2(3)	84055408	358	217	358	141	74	72	115	50	46	1	0.794	1.000	1.000
223	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	83	ACVR1(5), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(5), BMPR1B(4), BMPR2(6), CHRD(12), CREBBP(40), CUL1(11), DCN(4), E2F4(2), E2F5(6), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(4), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MYC(6), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), RBL1(11), RBL2(6), RBX1(3), ROCK1(19), ROCK2(10), RPS6KB1(5), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(3), SMURF2(6), SP1(3), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), ZFYVE16(10), ZFYVE9(8)	69028546	365	217	362	96	36	81	108	71	68	1	0.0108	1.000	1.000
224	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	73	ABL1(8), ACTN1(6), ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(3), BCAR1(3), BRAF(10), CAV1(1), CDC42(4), CRK(2), CSE1L(2), DOCK1(15), EPHB2(3), FYN(5), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(4), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CB(7), PKLR(3), PLCG1(8), PLCG2(9), PTK2(10), RAF1(3), RHO(3), ROCK1(19), ROCK2(10), SHC1(3), SOS1(9), SOS2(11), TLN1(24), TLN2(13), VASP(1), WAS(2), ZYX(2)	88152167	374	216	372	136	62	66	119	74	53	0	0.724	1.000	1.000
225	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(7), BDKRB1(3), BDKRB2(3), C1QA(3), C1QC(1), C1R(4), C1S(6), C2(2), C3(16), C3AR1(5), C4BPA(5), C4BPB(2), C5(11), C5AR1(2), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(3), CD55(1), CD59(1), CFB(8), CFH(19), CFI(5), CPB2(4), CR1(10), CR2(9), F10(4), F11(2), F12(2), F13A1(8), F13B(13), F2(3), F2R(4), F3(2), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), KNG1(5), MASP1(9), MASP2(5), MBL2(2), PLAT(3), PLAU(3), PLG(13), PROC(2), PROS1(9), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(8), SERPING1(5), TFPI(2), THBD(2), VWF(19)	67386746	389	213	386	136	49	99	113	69	58	1	0.538	1.000	1.000
226	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(5), BAD(2), BCL2(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(4), CREBBP(40), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(9), GSK3A(2), GSK3B(3), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(5), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB2(5), NFKBIB(2), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(19), RELA(2), RPL13A(2), SFN(7), SLA(3), SP1(3), SP3(3), TGFB1(2), TRAF2(2), TRPV6(7), VAV1(8), VAV2(4), VAV3(4), XPO5(4)	65282583	331	208	330	116	46	64	99	66	55	1	0.484	1.000	1.000
227	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(8), ATM(16), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND2(2), CCNE1(5), CCNE2(4), CDAN1(7), CDC14A(3), CDC14B(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CHEK1(1), CHEK2(5), DTX4(5), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), ESPL1(10), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), HDAC8(2), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(4), RB1(18), RBL1(11), SKP2(4), TBC1D8(4), TFDP1(3), TGFB1(2), WEE1(1)	77872752	308	202	307	105	35	72	78	58	65	0	0.663	1.000	1.000
228	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(5), ELK1(2), FOS(6), IKBKB(12), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(4), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAP4K5(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(8), MAPK6(3), MAPK7(6), MAPK8(4), MAPK9(5), MAPKAPK3(4), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MKNK2(3), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(5), RPS6KB2(2), SHC1(3), SP1(3), STAT1(7), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	70775698	330	201	325	107	58	68	107	52	45	0	0.353	1.000	1.000
229	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2L1(2), CDC42(4), CDKN1B(3), CREB1(1), CREB3(1), CREB5(8), EBP(1), ERBB4(22), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CD(8), PPP1R13B(2), PREX1(15), PTK2(10), PTPN1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SLC2A4(4), SOS1(9), SOS2(11), TSC1(5), TSC2(8), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	56091953	297	198	295	90	43	65	86	53	50	0	0.110	1.000	1.000
230	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(4), AKT3(6), BCL10(1), BLNK(5), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(9), FCGR2B(1), FOS(6), GSK3B(3), IKBKB(12), INPP5D(10), JUN(1), KRAS(1), LILRB3(5), LYN(8), MALT1(3), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NRAS(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(2), RAC3(3), RASGRP3(8), SYK(8), VAV1(8), VAV2(4), VAV3(4)	54401076	294	194	292	94	59	60	76	50	48	1	0.153	1.000	1.000
231	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(20), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(4), AKT3(6), CAMKK1(2), CAMKK2(6), CD36(2), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(7), IKBKB(12), IRS1(4), IRS2(6), IRS4(16), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), MAPK10(4), MAPK8(4), MAPK9(5), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NPY(5), PCK1(1), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(5), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), STK11(7), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8)	63166369	321	194	321	102	55	62	96	55	52	1	0.112	1.000	1.000
232	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(1), AKT1(2), AKT2(4), AKT3(6), APAF1(12), ATM(16), BAD(2), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CAPN1(3), CAPN2(6), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(8), FADD(4), FAS(5), FASLG(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(6), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(2)	60402234	270	188	267	86	48	61	64	49	48	0	0.225	1.000	1.000
233	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(4), AKT3(6), BTK(8), FCER1A(4), FYN(5), GAB2(4), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(10), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), MS4A2(5), NRAS(1), PDK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC2(2), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8), VAV2(4), VAV3(4)	52007868	282	185	280	95	50	49	87	47	48	1	0.471	1.000	1.000
234	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(11), EZH1(5), EZH2(5), FBXO11(7), HCFC1(8), HSF4(1), JMJD4(2), JMJD6(2), KDM6A(17), MEN1(3), OGT(4), PAXIP1(5), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(37), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(2), SATB1(6), SETD1A(11), SETD2(12), SETD7(4), SETD8(1), SETDB1(10), SETDB2(2), SETMAR(2), SMYD3(2), STK38(3), SUV39H1(5), SUV39H2(2), SUV420H1(8), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6)	86174587	281	182	276	79	43	52	85	50	51	0	0.142	1.000	1.000
235	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(9), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(4), MIOX(4), OCRL(4), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(9), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(8), PTPMT1(2), SYNJ1(10), SYNJ2(9)	54225122	272	182	267	92	54	51	80	48	39	0	0.189	1.000	1.000
236	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(2), AKT2(4), AKT3(6), BAD(2), CASP9(1), CDC42(4), KDR(13), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(4), NFAT5(13), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NOS3(4), NRAS(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PPP3R2(1), PRKCA(7), PRKCG(14), PTGS2(4), PTK2(10), PXN(3), RAC2(2), RAC3(3), RAF1(3), SHC2(5), SPHK2(5)	52040639	273	181	271	96	59	55	74	44	41	0	0.334	1.000	1.000
237	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(6), CCR1(1), CCR10(2), CCR2(5), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(3), GRPR(1), LHCGR(9), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), NMBR(3), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(7), OXTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), TACR1(3), TACR2(4), TACR3(6), TRHR(7), TSHR(4)	39301078	274	180	273	96	52	64	86	38	34	0	0.0308	1.000	1.000
238	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(6), CPSF2(5), CPSF3(2), CSTF1(2), CSTF2(2), CSTF2T(2), CSTF3(2), DDIT3(1), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(2), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(3), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(11), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(13), PTBP1(3), PTBP2(4), RBM17(1), RBM5(9), RNGTT(2), RNMT(5), RNPS1(5), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(4), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(5), SRPK1(1), SRPK2(8), SRRM1(4), SUPT5H(4), U2AF1(4), U2AF2(2), XRN2(8)	80511676	293	179	291	103	34	71	83	51	54	0	0.815	1.000	1.000
239	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(10), CPEB1(6), EGFR(21), ERBB2(11), ERBB4(22), ETS1(4), ETS2(7), ETV6(6), ETV7(4), FMN2(41), KRAS(1), MAP2K1(5), NOTCH2(21), NOTCH3(23), NOTCH4(8), PIWIL1(11), PIWIL2(9), PIWIL3(7), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1)	36177175	249	175	245	77	34	48	82	42	43	0	0.596	1.000	1.000
240	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), ALG6(4), CCKBR(6), CCR2(5), CCR3(6), CELSR1(23), CELSR2(25), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(4), GNRHR(3), GPR116(8), GPR132(4), GPR133(10), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR61(3), GPR84(3), GRM1(30), GRPR(1), HRH4(3), LGR6(10), LPHN2(11), LPHN3(24), LTB4R2(3), NTSR1(3), OR2M4(6), P2RY13(3), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2)	50653530	279	173	278	108	52	63	84	46	34	0	0.322	1.000	1.000
241	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(9), ARHGEF11(4), BTK(8), CDC42(4), CFL1(2), GDI1(4), GDI2(5), INPPL1(9), ITPR1(16), ITPR2(26), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CD(8), PIK3CG(20), PIK3R1(10), PITX2(2), PPP1R13B(2), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(10), SAG(1), WASF1(3), WASL(2)	50927844	253	169	251	101	42	65	65	45	35	1	0.741	1.000	1.000
242	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	CD14(1), CD19(4), CD1A(7), CD1B(3), CD1C(5), CD1D(5), CD2(1), CD22(3), CD33(2), CD34(6), CD36(2), CD37(1), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD55(1), CD59(1), CD7(2), CD8A(2), CD8B(2), CD9(1), CR1(10), CR2(9), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(3), EPO(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), GYPA(5), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL7(1), IL7R(6), IL9R(11), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(8), KIT(11), KITLG(1), MME(16), MS4A1(3), TFRC(7), THPO(1), TPO(11)	61431156	283	168	280	114	43	57	82	56	45	0	0.909	1.000	1.000
243	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2(1), BCR(2), BLNK(5), BTK(8), CD19(4), CD22(3), CR2(9), CSK(1), DAG1(5), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), INPP5D(10), ITPR1(16), ITPR2(26), ITPR3(10), LYN(8), MAP4K1(4), NFATC1(10), NFATC2(15), NR0B2(1), PDK1(3), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(19), RAF1(3), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8)	54031389	259	168	258	95	45	58	58	57	40	1	0.482	1.000	1.000
244	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2A(3), AMY2B(9), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(3), GCK(4), GPI(3), GUSB(5), GYS1(7), GYS2(7), HK1(4), HK2(5), HK3(8), MGAM(37), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), SI(61), UCHL3(1), UGDH(4), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14), UXS1(2)	43197822	255	167	253	83	30	48	82	52	41	2	0.494	1.000	1.000
245	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(16), CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG2(4), CDC25A(2), CDK4(5), CDKN1B(3), CDKN2C(1), CREB3(1), CREB3L1(4), CREB3L3(10), CREB3L4(2), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), GADD45A(1), GBA2(9), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MNAT1(1), MYC(6), MYT1(12), NACA(25), PCNA(1), POLA2(2), POLE(11), POLE2(1), PRIM1(3), RB1(18), RBL1(11), RPA1(5), RPA2(1), TFDP1(3), TFDP2(1), TNXB(23), WEE1(1)	57694492	255	166	252	71	29	67	72	38	48	1	0.0758	1.000	1.000
246	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(5), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(4), CHUK(6), CSK(1), CXCL1(3), EGFR(21), F11R(3), GIT1(5), IGSF5(4), IKBKB(12), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(5), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(8), PAK1(3), PLCG1(8), PLCG2(9), PTPN11(2), PTPRZ1(16), RELA(2), TCIRG1(8), TJP1(12)	53097613	243	163	242	75	27	54	75	48	39	0	0.303	1.000	1.000
247	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACADL(4), ACADM(3), ACOX1(2), ACOX2(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ANGPTL4(3), APOA2(1), APOA5(2), AQP7(3), CD36(2), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(3), CYP4A22(10), CYP7A1(6), CYP8B1(6), DBI(5), EHHADH(5), FABP1(4), FABP2(2), FABP3(1), FABP4(4), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(5), GK2(8), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(7), NR1H3(1), OLR1(1), PCK1(1), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRA(5), RXRB(3), RXRG(7), SCD(1), SCP2(2), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1)	48966333	226	159	225	84	40	51	65	31	38	1	0.536	1.000	1.000
248	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(4), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(21), EPHB2(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), PI3(2), PIK3CB(7), PITX2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), RAF1(3), RGS20(4), SHC1(3), SOS1(9), SOS2(11), STAT3(6)	43856905	228	159	227	76	33	51	64	57	23	0	0.267	1.000	1.000
249	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(7), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME6(1), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UPB1(2), UPP1(3), UPP2(4), UPRT(2)	61520900	242	158	242	92	40	43	67	51	41	0	0.864	1.000	1.000
250	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(5), APH1A(4), CREBBP(40), CTBP1(2), CTBP2(8), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(7), DVL2(1), DVL3(9), HDAC1(1), HDAC2(3), JAG1(7), JAG2(8), LFNG(3), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(24), NCSTN(2), NOTCH2(21), NOTCH3(23), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(8), RBPJL(5), RFNG(3), SNW1(5)	45988128	249	158	247	100	48	53	61	36	50	1	0.817	1.000	1.000
251	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(5), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(15), GLI3(12), GSK3B(3), HHIP(7), IHH(2), LRP2(42), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(14), PTCH2(11), RAB23(2), SHH(2), SMO(3), STK36(7), SUFU(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3), ZIC2(6)	46317598	240	158	239	90	52	46	83	34	25	0	0.567	1.000	1.000
252	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(27), AXIN1(11), CCND1(4), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(7), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(7), FZD2(4), FZD3(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(6), MAPK10(4), MAPK9(5), MYC(6), PAFAH1B1(1), PLAU(3), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), SFRP4(12), TCF7(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1)	45136374	248	155	244	85	40	53	78	50	26	1	0.274	1.000	1.000
253	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(2), APOA2(1), CD36(2), CPT1B(4), CREBBP(40), DUSP1(2), EHHADH(5), FABP1(4), HSD17B4(5), JUN(1), LPL(4), ME1(2), MYC(6), NCOA1(7), NCOR1(21), NCOR2(24), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(9), PIK3R1(10), PPARA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(4), RB1(18), RELA(2), RXRA(5), SP1(3), STAT5A(3), STAT5B(5)	42216979	220	154	213	63	25	54	59	30	51	1	0.0760	1.000	1.000
254	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(4), AKT3(6), BRD4(9), CAP1(6), CBL(3), CDC42(4), F2RL2(2), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), LNPEP(5), PARD3(15), PARD6A(1), PDK1(3), PIK3CD(8), PIK3R1(10), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(7), SHC1(3), SLC2A4(4), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	42074484	217	154	216	63	38	49	58	39	33	0	0.119	1.000	1.000
255	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(12), ATM(16), ATR(25), BAI1(8), BAX(2), BID(3), CASP3(2), CASP9(1), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(2), CHEK1(1), CHEK2(5), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(8), IGF1(1), IGFBP3(1), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(6), RCHY1(2), RFWD2(2), RRM2(1), RRM2B(1), SERPINE1(8), SESN1(3), SESN2(3), SESN3(3), SFN(7), SIAH1(5), STEAP3(4), THBS1(8), TNFRSF10B(1), TSC2(8), ZMAT3(2)	47227163	209	151	209	58	22	53	43	46	45	0	0.117	1.000	1.000
256	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(14), GNAS(12), GNAT3(6), GNB1(3), GNB3(7), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(4), SCNN1B(6), SCNN1G(6), TAS1R1(8), TAS1R2(3), TAS1R3(3), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R14(5), TAS2R16(4), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R40(8), TAS2R41(3), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(6)	43345617	230	150	228	108	50	42	54	47	37	0	0.932	1.000	1.000
257	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(13), KDR(13), NOS3(4), PDE2A(4), PDE3A(18), PDE3B(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKG1(8), PRKG2(2), RYR2(79), SLC7A1(4), SYT1(8)	30730065	205	149	205	74	34	52	58	37	23	1	0.516	1.000	1.000
258	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ACAT2(2), ACMSD(4), AFMID(6), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), NFX1(2), OGDH(11), OGDHL(12), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(4), TPH1(2), TPH2(6), WARS(2), WARS2(8)	45967534	202	147	202	65	29	45	64	32	32	0	0.306	1.000	1.000
259	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(6), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CRADD(1), DAXX(5), FADD(4), GSN(5), LMNA(1), LMNB1(1), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(2), NFKB1(5), NFKBIA(1), NUMA1(18), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(10), RB1(18), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	50295853	224	146	224	73	30	48	62	36	48	0	0.445	1.000	1.000
260	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(4), DGAT1(1), DGAT2(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), GK(5), GK2(8), GLA(3), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1)	44508420	201	144	200	61	26	44	53	41	37	0	0.113	1.000	1.000
261	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(4), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), PDPK1(4), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PRKAA1(4), PRKAA2(4), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), STK11(7), TSC1(5), TSC2(8), ULK1(8), ULK2(2), VEGFB(1), VEGFC(6)	38250667	198	144	195	54	34	42	52	32	38	0	0.0897	1.000	1.000
262	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	47	ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(40), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), IGF1(1), LIF(2), MAP2K1(5), MAPK14(2), MAPK8(4), MYH2(28), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NKX2-5(1), NPPA(3), PIK3R1(10), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(5), SYT1(8)	35440055	202	141	201	64	35	44	59	31	32	1	0.152	1.000	1.000
263	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB3(1), CREB5(8), CREBBP(40), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), NTRK1(3), OPN1LW(3), PIK3C2G(13), PIK3CD(8), PIK3R1(10), PTPN11(2), RPS6KA3(4), SHC1(3), TH(3)	36969164	187	141	185	50	28	34	51	34	39	1	0.0884	1.000	1.000
264	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(1), BAX(2), BTK(8), CAD(5), CASP10(3), CASP3(2), CD7(2), CSNK1A1(1), DAXX(5), DEDD(1), DEDD2(5), DIABLO(2), EGFR(21), EPHB2(3), FADD(4), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MET(4), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), NR0B2(1), PFN1(1), PTPN13(13), RALBP1(5), RIPK1(2), ROCK1(19), SMPD1(2), TNFRSF6B(4), TPX2(5), TRAF2(2), TUFM(2)	53450829	202	141	202	61	30	45	61	28	37	1	0.219	1.000	1.000
265	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(2), ACMSD(4), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(2), WARS(2), WARS2(8)	41837003	188	139	188	65	25	40	62	33	27	1	0.482	1.000	1.000
266	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(12), BAD(2), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(2), BIRC3(2), BIRC5(1), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CHUK(6), FADD(4), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(12), IRF1(8), IRF2(8), IRF3(3), IRF4(5), IRF5(3), IRF6(6), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), PLEKHG5(6), PRF1(4), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2), TRAF3(6)	42241605	192	138	189	56	37	50	43	23	39	0	0.0706	1.000	1.000
267	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(7), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	44194172	185	138	185	78	29	49	48	30	29	0	0.808	1.000	1.000
268	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C2(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(3), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7)	43717129	210	138	210	81	29	43	68	41	28	1	0.783	1.000	1.000
269	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(4), CDH1(5), CTNNB1(6), CTTN(12), FYN(5), HCLS1(2), ITGB1(17), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2)	39643784	205	138	202	74	34	48	60	25	37	1	0.446	1.000	1.000
270	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(4), CDH1(5), CTNNB1(6), CTTN(12), FYN(5), HCLS1(2), ITGB1(17), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1A(2), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(5), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2)	39643784	205	138	202	74	34	48	60	25	37	1	0.446	1.000	1.000
271	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), RRM1(1), RRM2(1), TXNRD1(6), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UNG(2), UPB1(2), UPP1(3)	43605398	187	138	187	60	27	34	59	32	35	0	0.374	1.000	1.000
272	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(2), AKT2(4), AKT3(6), BCR(2), BTK(8), CD19(4), FLOT1(2), FLOT2(4), GAB1(5), ITPR1(16), ITPR2(26), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(15), PTPRC(19), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SAG(1), SYK(8), TEC(2), VAV1(8)	39121694	194	138	193	70	28	48	46	40	31	1	0.470	1.000	1.000
273	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(21), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK10(4), MAPK14(2), PHKA2(9), PIK3CD(8), PIK3R1(10), PITX2(2), PTX3(4), RAF1(3)	38267398	198	137	196	63	30	45	52	41	30	0	0.213	1.000	1.000
274	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), GRAP2(2), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), NCK1(5), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLCG1(8), PTPRC(19), RAF1(3), RASGRP1(8), RASGRP2(7), RASGRP3(8), RASGRP4(3), SOS1(9), SOS2(11), VAV1(8), ZAP70(2)	40747494	188	136	188	64	25	36	58	27	42	0	0.586	1.000	1.000
275	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(2), CARM1(5), CYP11B1(7), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7)	38193915	185	135	185	60	34	33	60	36	22	0	0.374	1.000	1.000
276	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MIOX(4), OCRL(4), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9)	32377525	178	134	173	48	33	31	55	31	28	0	0.0607	1.000	1.000
277	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), ASCC3(13), ATP13A2(3), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(4), DDX56(4), DHFR(3), DHX58(2), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), FPGS(2), GGH(3), IFIH1(6), MOV10L1(6), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SKIV2L2(4), SMARCA2(13), SMARCA5(2)	47813003	180	132	180	55	23	36	58	35	28	0	0.365	1.000	1.000
278	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(4), CFL1(2), FLNA(23), FLNC(15), FSCN1(2), FSCN2(1), FSCN3(6), GDI1(4), GDI2(5), LIMK1(5), MYH2(28), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PFN1(1), RHO(3), ROCK1(19), ROCK2(10), VASP(1), WASF1(3), WASL(2)	36437833	191	132	191	75	32	45	53	28	33	0	0.659	1.000	1.000
279	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), OGDH(11), OGDHL(12), PIPOX(2), PLOD1(3), PLOD2(8), PLOD3(4), RDH11(2), RDH12(4), SETD1A(11), SETD7(4), SETDB1(10), SHMT1(1), SHMT2(2), SPCS1(2), SPCS3(1), SUV39H1(5), SUV39H2(2), TMLHE(2)	39947494	175	131	175	63	34	32	49	34	26	0	0.495	1.000	1.000
280	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), AKT2(4), AKT3(6), BAD(2), BCR(2), BLNK(5), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PI3(2), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8)	38028694	175	131	175	58	35	31	47	28	33	1	0.357	1.000	1.000
281	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(12), CARM1(5), CCND1(4), CREBBP(40), ERCC3(5), ESR1(6), GRIP1(11), GTF2A1(3), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), NCOR2(24), NR0B1(5), NRIP1(9), PELP1(2), POLR2A(11), TBP(2)	30546205	178	130	177	63	19	33	53	38	34	1	0.611	1.000	1.000
282	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(10), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), ATP5L(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX6A1(2), COX7A2(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(1), NDUFA2(1), NDUFA3(3), NDUFA5(3), NDUFA7(2), NDUFA9(2), NDUFB1(1), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(5), PPA1(1), SDHA(7), SDHB(1), SDHC(1), TCIRG1(8), UQCRC1(1), UQCRC2(1), UQCRFS1(4)	42404427	177	130	176	47	18	38	59	33	29	0	0.0872	1.000	1.000
283	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), GK(5), GLA(3), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1)	36570399	166	126	165	52	21	33	45	31	36	0	0.193	1.000	1.000
284	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(35), B3GALT4(4), CDR1(7), DGKI(11), IL6ST(4), MRPL19(3), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL18A(1), RPL22(1), RPL23(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(3), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(2), RPS24(1), RPS25(2), RPS26(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5)	39813299	179	126	179	71	21	39	67	25	27	0	0.909	1.000	1.000
285	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), F10(4), F11(2), F12(2), F2(3), F2R(4), F5(20), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), PROC(2), PROS1(9), SERPINC1(4), SERPING1(5)	33727835	171	125	170	55	16	52	47	31	25	0	0.585	1.000	1.000
286	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(6), DAXX(5), EGF(9), EGFR(21), ETS1(4), ETS2(7), FOS(6), HOXA7(4), IKBKB(12), JUN(1), MAP2K1(5), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(5), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(1), TNFRSF1B(2), TRAF2(2)	36684011	173	125	173	64	29	35	54	28	26	1	0.600	1.000	1.000
287	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(1), CDC42(4), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(4), MAP3K12(9), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(5), MYEF2(7), NFATC3(6), NR2C2(1), PAPPA(13), SHC1(3), TRAF6(3), ZAK(5)	37764870	173	125	170	45	28	40	58	25	22	0	0.106	1.000	1.000
288	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), CARM1(5), COMT(2), DBH(8), DCT(4), DDC(7), ECH1(2), ESCO1(4), ESCO2(4), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PNMT(1), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(8), TYRP1(4)	45187717	164	124	163	54	28	40	48	23	25	0	0.265	1.000	1.000
289	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PAK2(8), PIK3R1(10), PLA2G4A(3), PLCG1(8), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8)	30228030	159	123	159	39	30	26	46	29	27	1	0.0723	1.000	1.000
290	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(4), AKT3(6), ANKRD6(3), APC(27), AXIN1(11), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(7), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(34), MVP(5), NKD1(8), NKD2(3), PIN1(1), PTPRA(4), SENP2(3), SFRP1(4), TSHB(2), WIF1(1)	30754359	163	123	162	56	22	39	43	33	25	1	0.453	1.000	1.000
291	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKI(11), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(3), GNPAT(3), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(17), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(2)	49774432	185	122	184	52	20	38	55	31	41	0	0.113	1.000	1.000
292	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	34	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(7), GNA15(4), GNB1(3), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK14(2), NCF1(2), NCF2(6), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(13), PLCB1(21), PPP3CA(2), PPP3CB(1), RAF1(3), RELA(2), SYT1(8)	27927977	151	121	149	48	33	24	51	23	20	0	0.366	1.000	1.000
293	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	ALOX12(3), ALOX12B(5), ALOX15B(5), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP2U1(1), CYP4A22(10), CYP4F2(7), CYP4F3(4), DHRS4(2), EPHX2(4), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GPX6(4), GPX7(1), LTA4H(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5)	28776554	149	121	149	50	22	29	48	22	27	1	0.255	1.000	1.000
294	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	21	ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(5), EPHB2(3), GNAI1(2), ITPR1(16), ITPR2(26), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), PITX2(2), PTX3(4), RHO(3), RYR1(34)	33910438	158	121	157	60	31	36	38	26	27	0	0.413	1.000	1.000
295	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(4), AKT3(6), ARHGEF11(4), BCL2(1), CDC42(4), DLG4(5), GNA13(2), LPA(16), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PDK1(3), PHKA2(9), PI3(2), PIK3CB(7), PLD1(17), PLD2(1), PLD3(2), PTK2(10), RDX(1), ROCK1(19), ROCK2(10), SERPINA4(7), SRF(1), TBXA2R(1)	37381120	168	120	168	55	16	43	51	29	29	0	0.435	1.000	1.000
296	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(16), ACACB(20), ACAT2(2), ACOT12(3), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3)	35530493	149	119	149	58	31	26	44	29	19	0	0.822	1.000	1.000
297	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(5), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), NFKB1(5), NFKBIA(1), PIK3R1(10), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(5), RAF1(3), RELA(2), SHC1(3), SOS1(9), SYT1(8), VAV1(8), ZAP70(2)	32524611	154	119	154	39	31	28	44	22	29	0	0.0542	1.000	1.000
298	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	37124672	152	118	152	57	22	40	40	26	24	0	0.575	1.000	1.000
299	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	37124672	152	118	152	57	22	40	40	26	24	0	0.575	1.000	1.000
300	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(3), GCNT2(7), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(5), PIGS(2), PIGT(2), PIGU(2), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1), ST3GAL5(6), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1)	36951387	159	118	157	61	30	37	53	18	21	0	0.456	1.000	1.000
301	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(17), AR(6), ESR1(6), ESR2(1), ESRRA(5), HNF4A(7), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(2), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(8), NR2F1(3), NR2F2(9), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(5), PGR(5), PPARA(2), PPARD(1), PPARG(1), RARA(4), RARB(6), RARG(11), ROR1(9), RORA(4), RORC(3), RXRA(5), RXRB(3), RXRG(7), THRA(7), THRB(1), VDR(2)	31972831	171	118	169	50	31	30	59	25	25	1	0.130	1.000	1.000
302	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CFLAR(2), DAXX(5), FADD(4), FAF1(2), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(13), RB1(18), RIPK2(6), SPTAN1(24)	30163874	158	117	157	38	18	34	45	24	37	0	0.107	1.000	1.000
303	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(5), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(3), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(8), PLCG2(9), PPAP2A(1), PPAP2B(1)	37943344	155	116	154	50	20	26	47	26	36	0	0.282	1.000	1.000
304	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(7), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(37), PFKL(6), PFKM(6), PFKP(6), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2)	29300594	153	116	152	39	26	34	46	22	23	2	0.0186	1.000	1.000
305	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	70	CALR(2), CANX(3), CD4(1), CD74(3), CD8A(2), CD8B(2), CIITA(12), CREB1(1), CTSS(4), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(9), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), KIR2DL1(6), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(4), LGMN(5), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(2), TAP1(6), TAP2(6), TAPBP(5)	34088361	162	116	159	59	21	42	47	22	30	0	0.480	1.000	1.000
306	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(8), AKT1(2), AKT2(4), AKT3(6), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PDK1(3), PHKA2(9), PIK3CB(7), PITX2(2), PLD1(17), PLD2(1), PLD3(2), VN1R1(2)	34047169	141	116	141	50	17	43	32	27	22	0	0.323	1.000	1.000
307	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	32	BLNK(5), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8)	28435577	145	114	145	34	30	25	41	25	23	1	0.0230	1.000	1.000
308	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	30	ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(13), ITGA1(4), ITGB1(17), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(4), MAPK8(4), MET(4), PAK1(3), PIK3R1(10), PTK2(10), PTK2B(4), PTPN11(2), PXN(3), RAF1(3), RAP1B(3), SOS1(9), STAT3(6)	28841107	148	113	145	33	23	23	46	32	24	0	0.0347	1.000	1.000
309	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(18), EEF1A2(3), EEF1B2(1), EEF1D(4), EEF1G(2), EEF2(5), EEF2K(6), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G3(9), EIF5(3), EIF5A(5), EIF5B(6), ETF1(3), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1)	33334084	154	112	153	40	17	35	50	28	24	0	0.174	1.000	1.000
310	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(22), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(12), GNB1(3), JUN(1), MAP2K1(5), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(8)	26244007	143	111	142	34	36	28	40	22	17	0	0.00954	1.000	1.000
311	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(5), EPRS(4), FARS2(4), FARSA(1), FARSB(7), GARS(1), HARS(1), HARS2(3), IARS(11), IARS2(3), KARS(3), LARS(5), LARS2(2), MARS(4), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), SARS2(1), TARS(6), TARS2(4), VARS(6), VARS2(4), WARS(2), WARS2(8), YARS(7), YARS2(4)	41248531	145	111	145	38	17	30	48	29	21	0	0.117	1.000	1.000
312	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	EGFR(21), ELK1(2), GNAS(12), GNB1(3), IGF1R(13), ITGB1(17), KLK2(2), MAP2K1(5), MAP2K2(6), MKNK1(1), MKNK2(3), MYC(6), NGFR(2), PDGFRA(14), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(3), SOS1(9), STAT3(6)	24297470	148	110	145	32	36	28	48	19	17	0	0.00634	1.000	1.000
313	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(3), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4)	32250973	149	110	149	57	25	40	40	24	20	0	0.489	1.000	1.000
314	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	46	ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(4), ACAT2(2), ACOX1(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A22(10), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5)	36379858	137	110	137	49	15	32	39	29	22	0	0.595	1.000	1.000
315	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(4), ACTN1(6), ACTN2(11), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(5), ITGA1(4), ITGB1(17), JUN(1), MAP2K1(5), MAP2K2(6), MAPK8(4), PPP1R12B(5), PTK2(10), PXN(3), RAF1(3), ROCK1(19), SHC1(3), SOS1(9), TLN1(24), VCL(6), ZYX(2)	35055940	164	110	163	43	29	28	59	29	19	0	0.0926	1.000	1.000
316	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(4), ARHGAP4(9), ARHGAP5(10), ARHGAP6(10), ARHGEF1(9), ARHGEF11(4), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(3), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(4), PIP5K1B(9), PPP1R12B(5), ROCK1(19), TLN1(24), VCL(6)	34447041	162	110	162	63	25	36	48	34	19	0	0.863	1.000	1.000
317	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(2), ITGA9(3), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), MAP2K1(5), NR1I3(1), PAK1(3), PDE3A(18), PDE3B(4), PI3(2), PIK3C2G(13), PIK3CD(8), PIK3R1(10), PSME1(1), RIPK3(1), SGCB(3), VASP(1)	34730959	150	109	149	57	18	35	39	27	31	0	0.799	1.000	1.000
318	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(9), GABBR1(3), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(30), GRM2(10), GRM3(32), GRM4(2), GRM5(13), GRM7(19), GRM8(23)	15909035	149	108	147	44	32	29	46	29	13	0	0.0415	1.000	1.000
319	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS2(5), BLVRA(3), COX10(3), COX15(4), CP(8), CPOX(1), EARS2(5), EPRS(4), FECH(1), FTMT(6), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(2), PPOX(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), UROD(1), UROS(4)	32129286	146	108	146	59	17	23	57	35	14	0	0.952	1.000	1.000
320	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(6), CASP2(3), CASP3(2), CRADD(1), FADD(4), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(18), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TRADD(1), TRAF2(2)	28714380	145	108	144	42	19	26	47	23	30	0	0.353	1.000	1.000
321	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(16), ATR(25), BRCA1(12), BRCA2(22), CHEK1(1), CHEK2(5), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(9), RAD51(1), RAD9A(2), TREX1(4)	32865448	132	107	132	27	9	41	32	29	21	0	0.0328	1.000	1.000
322	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	35	AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(5), GNA11(4), GNAI1(2), GNB1(3), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK14(2), MAPK8(4), MAPT(9), MYLK(8), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), SYT1(8)	30749051	139	107	139	48	31	32	42	21	13	0	0.285	1.000	1.000
323	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(3), BTG1(1), CBX3(2), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(3), DNAJA1(3), EIF4G2(9), ETV6(6), G0S2(1), GFRA1(8), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(2), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(3), PPP1R3C(2), PPP2CB(3), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(2), ZFR(5)	27841024	126	107	126	42	17	24	45	23	17	0	0.708	1.000	1.000
324	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), EGF(9), EGFR(21), ELK1(2), FOS(6), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3)	24928734	131	107	131	32	17	29	38	22	24	1	0.0493	1.000	1.000
325	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(5), ABAT(7), ACY3(3), ADSL(5), ADSS(4), ADSSL1(6), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(1), DLAT(4), DLD(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1)	28751414	135	107	135	44	19	34	43	20	19	0	0.276	1.000	1.000
326	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(12), BAD(2), BAX(2), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CD40(7), CD40LG(5), CRADD(1), DAXX(5), FADD(4), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(2), NR3C1(6), NTRK1(3), PTPN13(13), RIPK1(2), TFG(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3)	32204174	131	106	131	36	21	35	32	22	21	0	0.102	1.000	1.000
327	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(3), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(5), TAF1(13), TAF10(4), TAF13(1), TAF1L(25), TAF2(8), TAF4(5), TAF4B(5), TAF5(7), TAF5L(4), TAF6(8), TAF6L(2), TAF7(2), TAF7L(5), TAF9(3), TBPL1(2), TBPL2(1)	27383127	136	104	135	46	19	31	39	24	23	0	0.660	1.000	1.000
328	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(3), AOC2(5), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(3), HAL(6), HARS(1), HARS2(3), HDC(4), HEMK1(1), HNMT(2), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(2), UROC1(5)	30069281	131	103	131	36	22	34	43	17	15	0	0.0325	1.000	1.000
329	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT2(2), ACSM1(8), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(5), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(6), L2HGDH(4), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PRDX6(1), RDH11(2), RDH12(4)	30830480	142	103	142	54	17	39	46	25	15	0	0.644	1.000	1.000
330	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F11(2), F12(2), F13B(13), F2(3), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), LPA(16), PLAT(3), PLAU(3), PLG(13), SERPINB2(2), SERPINE1(8), VWF(19)	26846529	148	102	147	42	15	40	44	26	23	0	0.174	1.000	1.000
331	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), FUK(3), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(5), MTMR1(1), MTMR2(5), MTMR6(4), PFKFB1(3), PFKFB2(5), PFKFB3(3), PFKFB4(1), PFKL(6), PFKM(6), PFKP(6), PGM2(3), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2)	28192307	119	102	119	36	24	27	32	22	14	0	0.108	1.000	1.000
332	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(7), POLM(2), POLQ(22), PRIM1(3), PRIM2(1), REV1(3), REV3L(25), RFC5(2)	30787268	126	102	125	31	20	29	31	20	26	0	0.0934	1.000	1.000
333	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), LALBA(1), LCT(17), MGAM(37), PFKM(6), PFKP(6), PGM1(5), PGM3(1)	24702425	124	101	123	29	20	30	34	17	21	2	0.0121	1.000	1.000
334	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(8), ATM(16), ATR(25), CCNA1(7), CCND1(4), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(3), DHFR(3), GSK3B(3), HDAC1(1), RB1(18), SKP2(4), TFDP1(3), TGFB1(2), TGFB2(3), TGFB3(1)	21884065	115	100	114	27	9	22	30	24	30	0	0.161	1.000	1.000
335	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(7), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(10), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), OXCT2(1), PCCA(9), PCCB(1)	32713574	129	100	128	43	16	34	34	27	18	0	0.503	1.000	1.000
336	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(3), HTR5A(8), HTR6(6), HTR7(7)	19574300	127	100	127	61	34	17	40	21	15	0	0.734	1.000	1.000
337	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(7), AKT1(2), AKT2(4), AKT3(6), BAD(2), BTK(8), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(10), PDK1(3), PPP1R13B(2), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	24676050	134	100	134	46	17	30	42	27	17	1	0.600	1.000	1.000
338	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(27), AXIN1(11), BTRC(1), CCND1(4), CREBBP(40), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(1), TLE1(8), WIF1(1), WNT1(2)	22357252	144	100	139	36	18	34	36	25	29	2	0.0525	1.000	1.000
339	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(5), APC(27), ATF2(1), AXIN1(11), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(12), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), MAP3K7(8), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR3(5), WNT1(2)	26210907	138	99	136	36	20	30	35	29	23	1	0.105	1.000	1.000
340	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(16), ATR(25), BRCA1(12), CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CDC34(4), CHEK1(1), CHEK2(5), GADD45A(1), MDM2(2), MYT1(12), PRKDC(28), RPS6KA1(10), WEE1(1), YWHAH(2), YWHAQ(3)	27511188	135	99	135	28	17	30	39	28	21	0	0.0540	1.000	1.000
341	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	22	ACTA1(4), CAPN1(3), CAPN2(6), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(21), ITGA1(4), ITGB1(17), MYLK(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTK2(10), PXN(3), TLN1(24)	24025925	130	99	128	43	24	23	40	25	17	1	0.444	1.000	1.000
342	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(21), IGF1R(13), MYC(6), POLR2A(11), PRKCA(7), RB1(18), TEP1(16), TERF1(5), TERT(4), TNKS(8), XRCC5(4)	20871413	116	99	114	39	14	30	30	18	23	1	0.266	1.000	1.000
343	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(8), ADRBK2(5), ARRB2(3), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(5), CLCA2(6), CLCA4(6), CNGA3(10), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(3), PRKG1(8), PRKG2(2), PRKX(1)	23203428	120	98	120	45	18	27	35	23	17	0	0.548	1.000	1.000
344	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(14), PIK3R1(10), PLD1(17), PPP1R12B(5), RALBP1(5), RPS6KB1(5), TRIO(22), VAV1(8), WASF1(3)	24567635	130	98	130	52	21	29	43	15	22	0	0.896	1.000	1.000
345	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	AGT(4), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(21), ELK1(2), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK8(4), MEF2A(3), MEF2B(5), MEF2D(1), PAK1(3), PRKCA(7), PTK2(10), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), SYT1(8)	23034129	113	97	113	34	18	19	40	25	11	0	0.336	1.000	1.000
346	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), NACA(25), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5)	38518834	143	97	142	52	15	38	48	18	23	1	0.848	1.000	1.000
347	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(3), CEBPB(1), DAZL(3), DMC1(2), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), NCOR1(21), NRIP1(9), PGR(5), PRLR(8), PTGER2(5), SMPD1(2), VDR(2), ZP2(6)	26643751	128	97	124	37	15	32	39	21	21	0	0.225	1.000	1.000
348	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(5), ADCY3(8), ADCY9(9), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(8), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6)	28098922	128	96	128	35	24	28	36	21	19	0	0.0589	1.000	1.000
349	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	19	ARHGAP5(10), DIAPH1(7), FYN(5), GSN(5), ITGA1(4), ITGB1(17), MAP2K1(5), MYLK(8), PFN1(1), PIK3R1(10), PTK2(10), PXN(3), RAF1(3), ROCK1(19), SHC1(3), TLN1(24)	25884604	134	95	133	36	21	23	36	29	25	0	0.238	1.000	1.000
350	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(7), ACACA(16), ACACB(20), ACADM(3), ACAT2(2), ACSS1(5), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	30167579	123	95	123	47	23	22	36	24	18	0	0.800	1.000	1.000
351	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), ELK1(2), FOS(6), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(14), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3)	22979223	115	95	115	27	17	26	35	14	23	0	0.0409	1.000	1.000
352	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(12), IRAK1(3), JUN(1), LY96(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(4), TLR2(3), TLR3(2), TLR4(16), TLR6(4), TLR7(8), TLR9(7), TOLLIP(2), TRAF6(3)	27776437	120	95	119	46	19	25	38	14	24	0	0.710	1.000	1.000
353	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(2), DLG4(5), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(8)	19451476	114	94	114	41	23	28	30	20	13	0	0.213	1.000	1.000
354	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(16), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3)	28074114	119	94	119	41	22	23	36	24	14	0	0.589	1.000	1.000
355	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(4), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(10), JAK1(11), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PPP1R13B(2), RPS6KB1(5), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), STAT6(5), TYK2(8)	26383894	120	94	120	44	19	24	39	24	14	0	0.628	1.000	1.000
356	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(3), CDC42(4), CREB1(1), CREB3(1), CREB5(8), DUSP1(2), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(6), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3)	24848235	114	94	112	35	17	24	32	23	18	0	0.320	1.000	1.000
357	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(27), AXIN1(11), CCND1(4), CD14(1), CTNNB1(6), DVL1(7), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(8), LEF1(6), LY96(2), NFKB1(5), PDPK1(4), PIK3R1(10), RELA(2), TIRAP(1), TLR4(16), TOLLIP(2), WNT1(2)	21801708	132	93	130	41	18	34	33	19	27	1	0.229	1.000	1.000
358	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), AVP(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(13), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), NFATC1(10), NFATC2(15), PIK3R1(10), PPP3CA(2), PPP3CB(1), SYT1(8), YWHAH(2)	24165674	115	93	115	41	21	23	28	28	15	0	0.345	1.000	1.000
359	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(22), CD3D(1), CD4(1), CREBBP(40), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2)	17491281	125	92	122	38	23	26	31	21	23	1	0.202	1.000	1.000
360	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	19	CCR3(6), CFL1(2), GNAS(12), GNB1(3), LIMK1(5), MAP2K1(5), NOX1(6), PIK3C2G(13), PLCB1(21), PPP1R12B(5), PRKCA(7), PTK2(10), RAF1(3), ROCK2(10)	18294635	108	92	106	32	18	21	39	14	16	0	0.445	1.000	1.000
361	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(22), CD3D(1), CD4(1), CREBBP(40), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2)	17491281	125	92	122	38	23	26	31	21	23	1	0.202	1.000	1.000
362	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(4), GIPR(2), GLP1R(2), GLP2R(3), GPR64(6), LPHN1(11), LPHN2(11), LPHN3(24), SCTR(2), VIPR1(1), VIPR2(6)	20246798	120	92	120	44	15	15	36	38	16	0	0.641	1.000	1.000
363	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(2), BAD(2), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), IL2RA(2), IL2RB(3), IRS1(4), JAK1(11), JAK3(6), MYC(6), NMI(6), PIK3R1(10), PTPN6(3), RAF1(3), RPS6KB1(5), SHC1(3), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8)	24980870	110	92	108	31	15	32	29	16	18	0	0.0560	1.000	1.000
364	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(1), CDC42(4), CREB1(1), DAXX(5), DDIT3(1), ELK1(2), HMGN1(1), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RIPK1(2), RPS6KA5(5), SHC1(3), STAT1(7), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	26494513	101	92	98	37	18	22	30	14	17	0	0.722	1.000	1.000
365	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(27), AXIN1(11), CREBBP(40), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(6), PITX2(2), TRRAP(22), WNT1(2)	21511275	135	92	133	31	23	29	32	27	22	2	0.0101	1.000	1.000
366	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), GAMT(2), GATM(4), GLUD1(4), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3)	33577243	117	91	117	39	22	25	33	21	16	0	0.367	1.000	1.000
367	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(22), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(8), PDGFRA(14), PIK3R1(10), PLCB1(21), PRKCA(7), PTK2(10), SMPD1(2)	18363045	108	91	106	30	15	23	36	17	17	0	0.124	1.000	1.000
368	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(10)	22321126	115	91	114	44	15	19	43	22	15	1	0.734	1.000	1.000
369	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(5), ALAS2(5), AMT(2), AOC2(5), AOC3(5), ATP6V0C(2), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), MAOA(1), MAOB(1), PLCB2(7), PLCG1(8), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(2), TARS(6)	31847778	117	90	117	47	28	20	40	19	10	0	0.690	1.000	1.000
370	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(10), ATP4B(2), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX6A1(2), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(7), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4)	28976279	116	90	114	27	16	29	34	24	13	0	0.0248	1.000	1.000
371	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	21	ATF2(1), BCR(2), BLNK(5), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK8IP3(8), PAPPA(13), RPS6KA1(10), RPS6KA3(4), SHC1(3), SOS1(9), SYK(8), VAV1(8), VAV2(4), VAV3(4)	23230646	107	90	107	27	25	14	30	15	23	0	0.123	1.000	1.000
372	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(4), AKT3(6), BAD(2), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(4), IRS2(6), JAK1(11), JAK3(6), MAP4K1(4), PDK1(3), PIK3CD(8), PIK3R1(10), PPP1R13B(2), RAF1(3), SHC1(3), SOCS1(1), SOS1(9), SOS2(11), STAT6(5)	25670668	114	90	114	36	19	24	32	24	15	0	0.260	1.000	1.000
373	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH9A1(3), AOX1(10), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), PCCA(9), PCCB(1), SDS(1)	27373833	108	90	107	34	11	22	32	25	18	0	0.550	1.000	1.000
374	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(7), ADC(1), ALDH5A1(1), CAD(5), CPS1(13), EARS2(5), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5)	30042916	109	89	109	51	19	25	26	20	19	0	0.932	1.000	1.000
375	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(7), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), MLYCD(3), SDS(1), SMS(3), UPB1(2)	22098133	114	88	114	31	12	30	38	22	12	0	0.125	1.000	1.000
376	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(16), C5(11), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(13), ITGAL(7), ITGB1(17), ITGB2(4), SELP(15), SELPLG(1), VCAM1(10)	17391670	115	88	114	35	12	32	35	17	19	0	0.155	1.000	1.000
377	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), ATP6V0C(2), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADHA(3), PLOD1(3), PLOD2(8), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(2)	28166869	110	88	110	45	19	18	28	24	21	0	0.780	1.000	1.000
378	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK11(4), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), PIK3CD(8), PIK3R1(10), SYT1(8), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3)	23475983	101	88	101	28	21	17	27	12	24	0	0.0927	1.000	1.000
379	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(7), ACACA(16), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	25172960	103	87	103	32	17	17	33	20	16	0	0.501	1.000	1.000
380	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(3), BAD(2), BRAF(10), CREB1(1), CREB3(1), CREB5(8), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(6), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MKNK1(1), MKNK2(3), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(8), RPS6KA3(4), SHC1(3), SOS1(9), SOS2(11), TRAF3(6)	21917671	121	87	120	32	26	22	37	21	15	0	0.104	1.000	1.000
381	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(2), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(11), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(8), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	21552481	103	86	102	30	13	24	36	17	13	0	0.224	1.000	1.000
382	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(3), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(3), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(8), TAF7(2), TAF9(3), TBP(2)	26651829	112	86	112	39	9	26	28	23	26	0	0.621	1.000	1.000
383	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(5), AMT(2), AOC2(5), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SARS2(1), SDS(1), SHMT1(1), SHMT2(2), TARS(6), TARS2(4)	32368566	109	85	109	45	27	20	39	15	7	1	0.720	1.000	1.000
384	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CHUK(6), CREBBP(40), DUSP1(2), IKBKB(12), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K7(8), MAPK11(4), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TLR2(3)	17962099	99	85	97	28	14	16	29	18	21	1	0.296	1.000	1.000
385	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), COMT(2), DBH(8), DCT(4), DDC(7), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(3), TPO(11), TYR(8)	24089511	104	85	103	40	18	25	31	12	18	0	0.517	1.000	1.000
386	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), RPE(1), UGDH(4), UGP2(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(14), UGT2B7(7), XYLB(3)	20775690	104	84	104	40	14	15	39	25	11	0	0.876	1.000	1.000
387	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(3), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(3)	26180325	99	84	99	44	23	20	20	17	19	0	0.801	1.000	1.000
388	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(10), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(8), VIP(1), VIPR2(6)	21280054	103	84	101	36	24	20	31	16	12	0	0.369	1.000	1.000
389	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), ALG9(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(2), RPN1(2), RPN2(6), ST6GAL1(3), STT3B(2)	32231042	113	83	113	41	15	23	38	18	19	0	0.668	1.000	1.000
390	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(17), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(4), LCAT(2), LDLR(6), LIPC(5), LPL(4), LRP1(34), SCARB1(1), SOAT1(5)	20853162	92	83	91	29	12	21	27	19	13	0	0.357	1.000	1.000
391	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(12), ATM(16), BAD(2), BAX(2), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(10), PXN(3), STAT1(7), TLN1(24)	20207506	104	82	104	28	13	30	25	20	16	0	0.176	1.000	1.000
392	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(26), ITPR3(10), NFAT5(13), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5)	27079943	103	82	103	40	10	36	27	17	13	0	0.519	1.000	1.000
393	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GH1(4), GHR(8), INSR(3), IRS1(4), JAK2(5), MAP2K1(5), PIK3R1(10), PLCG1(8), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(10), SHC1(3), SLC2A4(4), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5)	22651414	96	81	96	22	15	26	33	11	11	0	0.0192	1.000	1.000
394	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(7), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HIBCH(2), MLYCD(3), SMS(3), UPB1(2)	20536304	99	81	99	29	11	30	31	19	8	0	0.167	1.000	1.000
395	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(3), GALNT1(2), GALNT10(5), GALNT11(5), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(3), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(4), WBSCR17(9)	24558538	105	80	105	38	17	28	28	15	16	1	0.604	1.000	1.000
396	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(12), BAK1(1), BAX(2), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), FADD(4), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TRADD(1), TRAF2(2)	27021042	101	79	99	26	19	26	26	14	16	0	0.0776	1.000	1.000
397	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(22), AKT1(2), BAD(2), BAX(2), BCL2(1), BCL2L1(2), CSF2RB(8), IGF1(1), IGF1R(13), IL3(1), IL3RA(6), KIT(11), KITLG(1), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), YWHAH(2)	15019889	100	79	99	30	16	26	25	17	16	0	0.119	1.000	1.000
398	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(9), EGFR(21), FOS(6), JUN(1), MYC(6), NFKB1(5), PLCG1(8), PRKCA(7), RELA(2)	15307125	87	79	85	26	12	22	31	14	7	1	0.214	1.000	1.000
399	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(12), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP10(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), FADD(4), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2)	24567054	94	79	94	25	18	23	22	12	19	0	0.0803	1.000	1.000
400	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(7), CYP4F3(4), EPX(10), GGT1(4), LTA4H(1), MPO(8), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5), TPO(11)	21251910	96	79	95	46	22	18	27	11	18	0	0.849	1.000	1.000
401	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB3(1), CREB5(8), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(5)	21252265	95	79	94	22	13	24	25	15	18	0	0.0548	1.000	1.000
402	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(4), ARSE(2), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD1(2), SMPD3(2), SMPD4(5), SPHK2(5), SPTLC1(5), SPTLC2(3), UGCG(1)	27239418	95	78	95	44	20	24	26	12	13	0	0.716	1.000	1.000
403	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(2), CDC23(4), CDC26(1), CDC27(8), CUL1(11), CUL2(3), FBXW11(3), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(3), SMURF2(6), TCEB1(2), TCEB2(1), UBA1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(1), WWP1(7), WWP2(5)	28013249	96	78	96	37	9	30	21	21	15	0	0.805	1.000	1.000
404	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(2), TGFB2(3), TGFB3(1), TOLLIP(2), TRAF6(3)	22629746	91	78	90	34	18	17	26	12	18	0	0.723	1.000	1.000
405	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(8), DLG4(5), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK7(6), MAPK8(4), MYEF2(7), PLD1(17), PLD2(1), PLD3(2), PTK2(10), RAF1(3), RASAL1(5), TEC(2), VAV1(8)	20396850	94	78	94	23	8	21	26	18	20	1	0.0794	1.000	1.000
406	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	15	CBL(3), EGF(9), EGFR(21), MAP2K1(5), PTPRB(24), RAF1(3), SHC1(3), SOS1(9), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2)	16585991	87	77	87	26	14	14	28	19	11	1	0.405	1.000	1.000
407	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	BCAR1(3), CRK(2), CXCL12(6), CXCR4(2), GNAI1(2), GNB1(3), MAP2K1(5), NFKB1(5), PIK3C2G(13), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(10), PTK2B(4), PXN(3), RAF1(3), RELA(2)	18542196	88	76	87	29	15	14	26	15	18	0	0.628	1.000	1.000
408	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(7), ACO2(3), CLYBL(1), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(11), OGDHL(12), PC(14), PCK1(1), PCK2(4), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	22686178	94	76	93	37	19	18	29	15	13	0	0.639	1.000	1.000
409	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(7), ADSL(5), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), PC(14)	19803813	89	75	89	28	15	17	30	14	13	0	0.299	1.000	1.000
410	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(8)	18450820	85	75	85	31	14	16	25	19	11	0	0.491	1.000	1.000
411	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), EPRS(4), GAMT(2), GATM(4), GLUD1(4), GLUD2(10), GOT1(1), GOT2(3), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	27312081	95	75	95	33	20	17	23	22	13	0	0.529	1.000	1.000
412	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(40), DAXX(5), PAX3(6), PML(4), RARA(4), RB1(18), SIRT1(2), SP100(8), TNFRSF1A(1), TNFRSF1B(2)	13524169	90	75	89	27	9	17	25	13	25	1	0.375	1.000	1.000
413	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(3), NCOA1(7), NCOA2(8), NCOA3(9), NCOR2(24), POLR2A(11), RARA(4), RXRA(5), TBP(2)	18982669	93	75	93	25	12	21	25	23	12	0	0.110	1.000	1.000
414	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(2), CYP11B1(7), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14)	20760596	89	74	89	34	18	14	27	19	11	0	0.699	1.000	1.000
415	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(7), ALDH5A1(1), CAD(5), CPS1(13), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), GMPS(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5)	25243521	87	74	87	41	13	21	21	17	15	0	0.933	1.000	1.000
416	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2)	24044556	89	74	89	37	17	20	28	17	7	0	0.774	1.000	1.000
417	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(3), AP2M1(3), BAD(2), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PLCG1(8), PRKCE(3), PRKCZ(3), RAB5A(3), RPS6KB1(5), VAV2(4)	18709470	91	74	90	31	12	17	30	13	18	1	0.497	1.000	1.000
418	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(7), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(2), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1)	19612415	90	73	90	32	10	26	28	12	14	0	0.553	1.000	1.000
419	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(3), AGT(4), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), REN(3)	18588701	89	72	88	39	10	26	28	15	10	0	0.960	1.000	1.000
420	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), GCK(4), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), KHK(3), MPI(5), PFKFB1(3), PFKFB3(3), PFKFB4(1), PFKM(6), PFKP(6), PMM2(2), SORD(2), TPI1(4)	18131556	80	72	80	23	14	23	18	14	11	0	0.0729	1.000	1.000
421	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(2), CSF1R(2), DDX20(4), E2F4(2), ETS1(4), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), JUN(1), NCOR2(24), RBL1(11), RBL2(6), SIN3A(6), SIN3B(11)	19454627	92	71	92	29	16	27	23	14	12	0	0.157	1.000	1.000
422	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(14), BAIAP2(3), CASP1(2), CASP3(2), CASP7(3), GAPDH(2), INSR(3), ITCH(7), MAGI1(14), MAGI2(20), RERE(7), WWP1(7), WWP2(5)	17353403	89	71	89	36	13	26	22	16	12	0	0.834	1.000	1.000
423	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(10), ARHGEF1(9), GNA12(2), GNA13(2), GNB1(3), MYLK(8), PLCB1(21), PPP1R12B(5), PRKCA(7), ROCK1(19)	15718096	86	71	85	30	15	16	28	16	11	0	0.653	1.000	1.000
424	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(17), AP2A1(3), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(5), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(10), SYNJ2(9), SYT1(8)	16499519	81	71	81	35	11	15	27	15	13	0	0.922	1.000	1.000
425	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), FADD(4), IKBKB(12), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(16), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3)	18588574	83	71	82	30	15	17	26	13	12	0	0.560	1.000	1.000
426	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	25	BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP3K1(6), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), SYT1(8)	20509374	86	71	86	30	21	12	31	12	10	0	0.599	1.000	1.000
427	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), GHR(8), IRS1(4), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3R1(10), PRKCA(7), RPS6KB1(5)	18642654	89	70	88	26	3	25	23	14	24	0	0.449	1.000	1.000
428	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(5), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2)	18542350	82	70	82	24	11	18	31	12	10	0	0.183	1.000	1.000
429	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(4), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(13), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3)	22360443	80	70	80	25	18	21	22	11	8	0	0.221	1.000	1.000
430	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(6), CHIT1(4), CTBS(3), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(5), HK3(8), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(4)	21800018	82	70	82	28	21	17	21	8	15	0	0.402	1.000	1.000
431	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4)	18172097	85	70	85	30	11	16	36	12	9	1	0.498	1.000	1.000
432	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), HAL(6)	16146378	79	70	79	33	16	17	21	16	9	0	0.834	1.000	1.000
433	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(8), ACE2(3), AGT(4), AGTR2(2), CMA1(5), CPA3(7), CTSA(2), CTSG(1), ENPEP(14), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1)	15535590	83	70	83	32	11	13	32	15	12	0	0.697	1.000	1.000
434	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(6), P4HB(1), SLC23A1(3), SLC23A2(7), SLC2A1(4), SLC2A3(2)	18991315	89	70	88	40	10	27	24	17	11	0	0.948	1.000	1.000
435	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(4), DARS(5), EPRS(4), FARS2(4), GARS(1), HARS(1), IARS(11), KARS(3), LARS(5), LARS2(2), MARS(4), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(7)	24299185	84	69	84	21	7	14	33	21	9	0	0.231	1.000	1.000
436	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(4), PIK3R1(10), RPS6KB1(5), TSC1(5), TSC2(8)	18753629	87	69	86	22	6	22	23	10	26	0	0.275	1.000	1.000
437	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(6), ACTN2(11), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(31), CTNNB1(6), PTK2(10), PXN(3), VCL(6)	14613213	85	68	83	36	11	18	30	13	12	1	0.896	1.000	1.000
438	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3R1(10), RAF1(3), SOS1(9), STAT1(7), STAT5A(3), STAT5B(5)	19413464	80	68	78	25	9	24	25	8	14	0	0.293	1.000	1.000
439	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(30), PLCB1(21), PPP1CA(1), PPP1R1B(2), PPP3CA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	12136445	83	67	81	30	16	21	24	18	4	0	0.337	1.000	1.000
440	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAPN2(6), CAPNS1(2), CAPNS2(2), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(10), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(8)	14816740	78	67	77	26	13	17	21	19	8	0	0.308	1.000	1.000
441	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(5), GADD45A(1), JUN(1), MAPK8(4), MDM2(2), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(2)	22063335	78	66	77	24	6	20	24	14	14	0	0.656	1.000	1.000
442	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(5), CCR3(6), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(2), TGFB2(3), TGFB3(1)	15203829	79	66	78	26	10	13	26	14	16	0	0.354	1.000	1.000
443	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(5), IKBKB(12), JAK2(5), LIN7A(5), NFKB1(5), NFKBIA(1), RB1(18), RELA(2), TNFRSF1A(1), TNFRSF1B(2), USH1C(7), WT1(3)	13216630	75	66	74	23	6	12	24	10	23	0	0.421	1.000	1.000
444	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(10), NFATC2(15), NFATC3(6), NFATC4(4), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(8)	15979389	73	63	73	25	15	14	22	15	7	0	0.410	1.000	1.000
445	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(7), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), METTL2B(4), METTL6(3), PAPSS1(6), PAPSS2(6), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(3)	18938494	77	62	77	23	18	21	19	12	7	0	0.132	1.000	1.000
446	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(3)	15532358	72	62	72	31	13	15	14	16	14	0	0.802	1.000	1.000
447	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(6), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7)	12508670	71	62	71	23	15	14	19	11	12	0	0.269	1.000	1.000
448	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(17), ITGB2(4), SELE(7), SELL(2), SELP(15)	12108439	82	62	81	29	9	18	22	12	21	0	0.525	1.000	1.000
449	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(5), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), HAL(6)	14444489	68	62	68	28	12	16	18	15	7	0	0.804	1.000	1.000
450	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3)	15543179	68	62	68	25	11	13	19	16	9	0	0.458	1.000	1.000
451	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(3), CP(8), CPOX(1), EPRS(4), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14), UROD(1), UROS(4)	20864118	70	62	70	35	8	11	25	17	9	0	0.987	1.000	1.000
452	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), ESCO1(4), ESCO2(4), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11)	26016506	76	61	75	37	15	16	27	7	11	0	0.924	1.000	1.000
453	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(2), ACP5(2), ACP6(6), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CMBL(2), CYP3A4(6), CYP3A43(3), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(10), PON2(1), PON3(6)	13706360	70	61	69	27	10	10	23	13	14	0	0.773	1.000	1.000
454	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GPX6(4), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(3), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), OPLAH(6)	16828021	72	61	72	31	14	18	20	13	7	0	0.610	1.000	1.000
455	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(20), AKT1(2), ATM(16), BAX(2), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(4), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(2), NQO1(3)	15197591	67	61	67	21	11	14	18	10	14	0	0.568	1.000	1.000
456	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(3), CASP2(3), CHUK(6), CRADD(1), IKBKB(12), JUN(1), LTA(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(1), TRADD(1), TRAF2(2)	18415390	67	61	67	25	13	12	21	9	12	0	0.665	1.000	1.000
457	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(9), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(4), MAPK14(2), NFATC1(10), NFATC2(15), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	9250727	63	60	63	25	19	13	13	9	9	0	0.324	1.000	1.000
458	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK14(2), NFKB1(5), PIK3R1(10), RB1(18), RELA(2), SP1(3)	12579283	65	60	65	22	10	7	17	5	26	0	0.821	1.000	1.000
459	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15)	15808855	64	59	64	31	14	11	23	9	7	0	0.929	1.000	1.000
460	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6)	17108010	64	59	64	22	12	14	17	7	14	0	0.448	1.000	1.000
461	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(22), CFTR(14), GNAS(12), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1)	9965823	65	58	64	19	18	14	18	9	6	0	0.236	1.000	1.000
462	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(22), GNAS(12), GNB1(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	11662340	69	58	68	22	20	11	20	10	8	0	0.481	1.000	1.000
463	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(10), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(4), QPRT(1)	16385816	70	58	70	36	9	9	23	18	11	0	0.984	1.000	1.000
464	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX2(2), PRDX6(1), TAT(1), TPO(11)	16695952	68	58	67	32	15	15	23	6	9	0	0.769	1.000	1.000
465	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(22), GNAS(12), PLCE1(21), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAP2B(2)	11244945	73	58	72	22	20	15	21	8	9	0	0.246	1.000	1.000
466	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(9), COMT(2), DBH(8), DDC(7), GAD1(4), GAD2(7), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(2)	10979411	64	57	64	28	10	13	23	5	13	0	0.739	1.000	1.000
467	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(7), POLQ(22)	12728592	61	57	61	16	11	13	14	7	16	0	0.155	1.000	1.000
468	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(15), DNMT3B(9), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), MTAP(4), MTFMT(4), MTR(8), TAT(1)	15762418	72	57	72	25	11	16	15	14	16	0	0.343	1.000	1.000
469	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(3), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(11), ENPP6(5), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(17), PLD2(1), PPAP2A(1), PPAP2B(1)	17648206	76	57	76	21	6	21	23	14	12	0	0.156	1.000	1.000
470	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(8), TPI1(4)	15364646	65	57	65	23	10	14	23	11	7	0	0.519	1.000	1.000
471	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(30), MAP2(21), PPP1CA(1), PRKACB(3), PRKACG(3), PRKAR2B(3), PRKCE(3)	13782702	64	56	63	20	4	7	24	11	18	0	0.819	1.000	1.000
472	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(10), CR2(9), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19)	11557965	64	56	63	29	4	17	17	10	16	0	0.910	1.000	1.000
473	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(6), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2), VNN1(3)	13169729	71	56	71	29	8	15	23	16	9	0	0.823	1.000	1.000
474	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSD(4), ARSE(2), ASAH1(1), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SMPD1(2), SPTLC1(5), SPTLC2(3), UGCG(1)	18358974	63	55	63	33	14	16	17	6	10	0	0.894	1.000	1.000
475	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(9), ABCG2(4), BCHE(5), CES1(7), CES2(11), CYP3A4(6), CYP3A5(1), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1)	17365735	66	55	66	35	13	10	26	9	8	0	0.951	1.000	1.000
476	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(16), CPT1A(6), LEP(1), LEPR(20), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2)	10992549	59	55	59	30	9	8	21	9	12	0	0.989	1.000	1.000
477	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), SOAT2(2)	17667332	65	54	65	27	10	11	20	15	9	0	0.842	1.000	1.000
478	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(8), F2(3), F2R(4), FGA(10), FGB(4), FGG(6), PLAT(3), PLAU(3), PLG(13), SERPINB2(2), SERPINE1(8)	10177414	68	54	68	24	6	17	18	9	18	0	0.669	1.000	1.000
479	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(7), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), HADHA(3), SH3GLB1(2), YOD1(4)	23523236	65	54	65	27	3	14	22	17	9	0	0.874	1.000	1.000
480	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(4), POLR1C(3), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1)	17836859	71	54	71	21	6	16	20	13	16	0	0.351	1.000	1.000
481	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(2), IL22RA1(4), IL22RA2(1), JAK1(11), JAK2(5), JAK3(6), SOCS3(1), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8)	13969727	64	54	64	26	8	19	18	10	9	0	0.527	1.000	1.000
482	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(4), IARS(11), IARS2(3), ILVBL(6), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(6), VARS2(4)	14172257	64	53	64	23	3	24	21	7	9	0	0.571	1.000	1.000
483	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(7), ST3GAL6(4), ST8SIA1(3)	12353169	57	53	55	20	9	15	23	5	5	0	0.356	1.000	1.000
484	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(2), ATIC(6), DHFR(3), FTCD(3), GART(4), MTFMT(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2)	14376024	64	53	64	24	9	6	25	10	13	1	0.762	1.000	1.000
485	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(6), BIRC2(2), BIRC3(2), CASP3(2), CFLAR(2), FADD(4), JUN(1), MAP2K4(2), MAP3K3(3), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(2), NFKBIE(1), NFKBIL1(2), NR2C2(1), RALBP1(5), RIPK1(2), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	19926143	68	53	67	23	16	20	16	7	9	0	0.304	1.000	1.000
486	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(4), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), GAMT(2), GATM(4), GLUD1(4), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3)	13320479	55	53	55	16	15	15	14	7	4	0	0.152	1.000	1.000
487	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(2), IKBKB(12), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2)	14780390	60	52	60	20	9	9	21	7	14	0	0.624	1.000	1.000
488	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(7), ACO2(3), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(14), PCK1(1), SDHA(7), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	15649727	61	52	60	22	10	16	18	10	7	0	0.413	1.000	1.000
489	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(11), EGF(9), EGFR(21), HGS(2), RAB5A(3), TF(5), TFRC(7)	9752921	58	52	58	21	5	13	17	12	10	1	0.764	1.000	1.000
490	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(2), ACP5(2), ACP6(6), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(6), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), PHPT1(1), TYR(8)	11427331	59	52	59	18	11	6	24	7	11	0	0.641	1.000	1.000
491	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(1), GOSR1(4), GOSR2(2), SNAP25(3), STX11(6), STX12(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(2), VTI1A(1), YKT6(1)	12701549	59	52	58	18	11	13	17	4	14	0	0.320	1.000	1.000
492	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3)	13818226	55	51	55	18	10	12	15	5	13	0	0.472	1.000	1.000
493	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(4), ULK1(8), ULK2(2)	16075307	59	51	59	27	8	8	27	11	5	0	0.952	1.000	1.000
494	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8)	14191291	60	51	60	23	5	13	18	8	16	0	0.772	1.000	1.000
495	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), JAK1(11), PTPRU(9), REG1A(13), STAT1(7), STAT2(6), TYK2(8)	9506297	57	51	57	22	9	15	15	7	11	0	0.550	1.000	1.000
496	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	CD2(1), CD33(2), CD5(1), CD7(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(7), TLR2(3), TLR4(16), TLR7(8), TLR9(7)	14151845	59	50	59	25	9	12	17	9	12	0	0.660	1.000	1.000
497	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX1(3), GPX2(1), GPX3(1), GPX4(2), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(7), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), PGD(2)	13740469	58	50	58	22	13	14	14	10	7	0	0.470	1.000	1.000
498	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(2), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(13), INPPL1(9), PDK2(1), PDPK1(4), PIK3R1(10), RPS6KB1(5)	12712212	63	50	62	18	9	18	13	7	16	0	0.301	1.000	1.000
499	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(16), ACACB(20), FASN(10), MCAT(3), OLAH(3), OXSM(3)	12070202	55	49	55	23	13	12	14	11	5	0	0.658	1.000	1.000
500	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(20), ABCB11(9), ABCB4(13), ABCC1(5), ABCC3(4), GSTP1(1)	10885488	52	49	52	24	7	10	18	3	14	0	0.806	1.000	1.000
501	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(2), ATIC(6), ATP6V0C(2), DHFR(3), GART(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2)	13581168	59	49	59	25	9	5	26	9	9	1	0.894	1.000	1.000
502	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	13	AKT1(2), AKT2(4), AKT3(6), BPNT1(2), ILK(4), PDK1(3), PIK3CD(8), PTK2B(4), RBL2(6), SHC1(3), SOS1(9)	12749744	51	49	51	17	12	9	15	11	4	0	0.469	1.000	1.000
503	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPHN(5), NSF(1), UBQLN1(2)	9111054	58	48	57	26	5	11	21	9	12	0	0.953	1.000	1.000
504	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4)	10912235	54	48	54	23	11	14	12	10	7	0	0.644	1.000	1.000
505	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGB1(17), ITGB2(4), SELE(7), SELL(2)	9205718	59	48	58	23	7	14	14	8	16	0	0.634	1.000	1.000
506	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2)	10610737	58	48	58	22	7	10	19	14	8	0	0.775	1.000	1.000
507	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(21), PLCB2(7), PRL(4), TRH(2), VIP(1)	8460897	52	48	51	23	6	7	24	10	5	0	0.844	1.000	1.000
508	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPX1(3), PRKCE(3), SOD1(1)	5981221	55	47	54	19	5	8	22	8	12	0	0.743	1.000	1.000
509	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(15), DNMT3B(9), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), MTR(8)	13211457	59	47	59	23	10	14	13	12	10	0	0.518	1.000	1.000
510	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(5), HK3(8), PGM3(1), RENBP(5), UAP1(4)	12878816	48	46	48	16	13	14	9	6	6	0	0.352	1.000	1.000
511	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(12), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), GZMB(2), LMNA(1), LMNB1(1), LMNB2(8), PRF1(4)	13797785	54	46	54	14	10	13	9	13	9	0	0.211	1.000	1.000
512	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(4), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(5), PIGS(2), PIGT(2), PIGU(2), PIGV(1), PIGW(2), PIGX(2), PIGZ(2)	18076612	53	46	53	32	8	13	16	6	10	0	0.989	1.000	1.000
513	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(4), UGT1A1(2), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A8(2), UGT1A9(1), UGT2B15(4), UGT2B4(14)	13372374	49	46	49	25	9	4	15	15	6	0	0.963	1.000	1.000
514	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(2), AKT2(4), AKT3(6), ELK1(2), MAP2K1(5), MAP2K2(6), NGFR(2), NTRK1(3), PIK3CD(8), SHC1(3), SOS1(9)	10293649	50	46	50	17	15	6	15	11	3	0	0.482	1.000	1.000
515	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(2), CHRNB1(1), CHRNG(9), MUSK(7), PIK3R1(10), PTK2(10), PTK2B(4), TERT(4), YWHAH(2)	10798624	51	45	51	23	8	10	13	9	11	0	0.786	1.000	1.000
516	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(3), LCT(17), MPI(5), PGM1(5), PYGL(9), PYGM(8), TPI1(4), TREH(1)	10134954	56	45	56	19	10	15	16	8	7	0	0.263	1.000	1.000
517	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2)	15482055	50	45	50	25	15	8	12	6	9	0	0.825	1.000	1.000
518	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(7), ACO2(3), AFMID(6), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3)	10171935	51	45	51	16	6	13	17	8	6	1	0.483	1.000	1.000
519	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(3), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(2), SLC25A20(3)	12775859	51	45	51	20	5	13	11	12	10	0	0.762	1.000	1.000
520	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(5), GALNT2(7), GALNT3(6), GALNT6(4), GALNT7(3), GALNT8(6), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(9)	10976813	47	44	47	20	8	14	12	5	7	1	0.699	1.000	1.000
521	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4)	13746524	49	43	49	18	9	10	16	9	5	0	0.565	1.000	1.000
522	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(2), BAX(2), BCL2(1), FADD(4), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), SMPD1(2), TNFRSF1A(1), TRADD(1), TRAF2(2)	14253683	50	43	50	23	12	6	19	6	7	0	0.910	1.000	1.000
523	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(5), AOC3(5), CES1(7), DDHD1(5), ESCO1(4), ESCO2(4), LIPA(3), PLA1A(8), PRDX6(1), SH3GLB1(2)	19292782	49	43	49	12	4	12	19	9	5	0	0.268	1.000	1.000
524	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(10), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5E(1), QPRT(1)	11070058	51	43	51	27	4	7	19	13	8	0	0.981	1.000	1.000
525	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(3), FOS(6), JUN(1), OPRK1(7), POLR2A(11), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	9805793	45	42	45	17	9	12	12	7	5	0	0.497	1.000	1.000
526	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(9), EGFR(21), ERBB3(14), NRG1(4)	7831161	48	42	48	17	5	12	12	13	5	1	0.686	1.000	1.000
527	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4(1), IL4R(8), IRS1(4), JAK1(11), JAK3(6), RPS6KB1(5), SHC1(3), STAT6(5)	11221458	45	42	45	13	7	11	12	8	7	0	0.220	1.000	1.000
528	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(3)	15241478	55	42	55	18	9	9	15	9	13	0	0.448	1.000	1.000
529	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(4), DHFR(3), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(1)	9527178	46	42	46	16	12	5	18	2	9	0	0.554	1.000	1.000
530	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(3), CD3D(1), CD8A(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2)	8175122	45	42	45	22	4	8	10	9	14	0	0.872	1.000	1.000
531	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(5), ARFGEF2(14), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(3)	12328265	47	41	47	14	5	17	12	4	9	0	0.219	1.000	1.000
532	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(7), ACO2(3), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3)	9711714	45	41	45	16	6	10	16	7	5	1	0.666	1.000	1.000
533	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(5), ESR1(6), GREB1(19), HSPB2(2), MTA1(8), MTA3(2), PDZK1(1), TUBA8(2)	8345615	46	41	46	22	12	3	17	8	6	0	0.852	1.000	1.000
534	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2)	8577979	44	41	44	22	3	8	10	10	13	0	0.885	1.000	1.000
535	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), WASF1(3), WASF2(5), WASF3(7), WASL(2)	11260187	46	40	46	22	10	10	12	9	5	0	0.942	1.000	1.000
536	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(1), DHCR24(1), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(5), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2), VKORC1(2)	14668829	45	40	45	18	11	11	10	5	8	0	0.577	1.000	1.000
537	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(5), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(5), ST3GAL4(1)	9584644	48	40	48	22	20	8	14	2	4	0	0.728	1.000	1.000
538	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(2), YOD1(4)	19773448	44	40	44	16	2	11	12	12	7	0	0.675	1.000	1.000
539	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(4), PAK1(3), PDGFRA(14), PIK3R1(10), WASL(2)	8177237	41	39	41	16	5	8	13	6	9	0	0.899	1.000	1.000
540	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2)	12562163	43	39	43	21	12	6	12	6	7	0	0.829	1.000	1.000
541	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(4), EPX(10), MPO(8), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11)	8827971	42	38	41	22	15	6	15	3	3	0	0.892	1.000	1.000
542	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(6)	12149192	43	38	43	15	3	8	16	11	5	0	0.710	1.000	1.000
543	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(2), CAT(4), EPX(10), MPO(8), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11)	8975989	44	38	43	21	14	6	16	5	3	0	0.830	1.000	1.000
544	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), FDXR(4), SHMT1(1)	12146771	50	38	50	14	6	9	18	9	8	0	0.375	1.000	1.000
545	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(5), SELL(2), SPN(3), TGFB1(2), TGFB2(3), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2)	10031334	43	38	43	19	6	12	11	10	4	0	0.658	1.000	1.000
546	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(3), PER3(7)	12977866	44	37	44	17	11	11	10	9	3	0	0.573	1.000	1.000
547	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(2), IL1A(1), IL6(2), JAK1(11), STAT1(7), STAT3(6), STAT5A(3)	9254119	41	37	41	20	3	15	11	6	6	0	0.651	1.000	1.000
548	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), JAK2(5), STAT4(6), TYK2(8)	11170748	45	37	45	19	4	10	14	7	10	0	0.789	1.000	1.000
549	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(6), TYR(8)	7388664	41	37	41	14	5	6	19	4	7	0	0.699	1.000	1.000
550	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(2), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3)	11090459	37	37	36	13	4	9	12	1	11	0	0.598	1.000	1.000
551	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(3), RPL8(1), RPS13(2), RPS15A(1), RPS20(1), RPS21(1), RPS23(2), RPS24(1), RPS25(2), RPS26(1), RPS28(1), RPS3(1), RPS5(1)	17258755	45	36	45	21	5	10	17	4	9	0	0.879	1.000	1.000
552	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(4), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), TBXA2R(1)	8514322	41	36	41	22	8	8	17	5	3	0	0.770	1.000	1.000
553	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11410965	46	35	46	13	5	9	15	9	8	0	0.384	1.000	1.000
554	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11410965	46	35	46	13	5	9	15	9	8	0	0.384	1.000	1.000
555	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(5), GPR161(4), GPR171(3), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(3), GPR75(5)	7484334	38	35	38	19	11	7	7	7	6	0	0.857	1.000	1.000
556	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1)	9523891	40	35	40	16	8	5	15	7	5	0	0.752	1.000	1.000
557	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2)	18987938	41	35	41	16	3	12	8	10	8	0	0.754	1.000	1.000
558	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(5), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(4)	8603698	38	35	38	12	6	11	10	6	5	0	0.430	1.000	1.000
559	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(10), MPO(8), PRDX2(2), PRDX6(1), TPO(11), TYR(8)	7343191	40	35	39	18	11	4	17	4	4	0	0.818	1.000	1.000
560	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(2), ATP6V0C(2), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11410965	46	35	46	13	5	9	15	9	8	0	0.384	1.000	1.000
561	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1)	7603533	41	35	41	13	0	16	14	6	5	0	0.622	1.000	1.000
562	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(8), ASPH(11), COPS5(2), CREB1(1), EDN1(1), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(4), P4HB(1)	9165972	35	34	35	14	6	10	7	9	3	0	0.655	1.000	1.000
563	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNAR2(3), JAK1(11), STAT1(7), STAT2(6), TYK2(8)	8257040	38	34	38	16	5	11	7	6	9	0	0.673	1.000	1.000
564	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RELA(2)	6273776	36	34	35	12	5	6	15	6	4	0	0.519	1.000	1.000
565	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8)	7970737	39	34	39	14	8	8	9	7	7	0	0.578	1.000	1.000
566	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8)	7970737	39	34	39	14	8	8	9	7	7	0	0.578	1.000	1.000
567	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6)	5331209	37	33	37	19	4	10	15	4	4	0	0.874	1.000	1.000
568	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(7), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1)	8797320	34	33	34	14	3	9	10	4	8	0	0.895	1.000	1.000
569	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(8), EPO(2), EPOR(2), GRIN1(4), HIF1A(3), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1)	9657990	33	33	33	11	4	11	6	7	5	0	0.358	1.000	1.000
570	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1)	9244748	36	33	36	13	4	5	12	9	6	0	0.703	1.000	1.000
571	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(6), ITGAL(7), ITGAM(8), ITGB2(4), SELE(7), SELL(2)	7886915	37	33	37	21	4	9	7	5	12	0	0.895	1.000	1.000
572	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(10), PON2(1), PON3(6), RDH11(2), RDH12(4)	6840643	37	32	36	17	3	7	11	11	5	0	0.830	1.000	1.000
573	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), LTA(4), TGFB1(2), TGFB2(3), TGFB3(1)	10113759	34	32	33	18	5	8	7	8	6	0	0.931	1.000	1.000
574	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(19), ZAP70(2)	6869407	36	32	35	18	3	8	8	7	10	0	0.907	1.000	1.000
575	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH7A1(2), ALDH9A1(3)	10054416	33	31	33	14	4	8	8	8	5	0	0.777	1.000	1.000
576	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(2), HDAC9(16), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), YWHAH(2)	5163667	33	31	33	11	7	5	9	9	3	0	0.516	1.000	1.000
577	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(3), GGT1(4), MARS(4), MARS2(5), MAT1A(1), MAT2B(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(1)	9404841	33	31	33	12	8	10	7	6	2	0	0.443	1.000	1.000
578	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(11), JAK2(5), JAK3(6), STAT3(6), TYK2(8)	8386337	36	31	36	13	5	6	10	9	6	0	0.572	1.000	1.000
579	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(7), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	7004272	32	30	32	15	10	3	8	5	5	1	0.837	1.000	1.000
580	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(7), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	7004272	32	30	32	15	10	3	8	5	5	1	0.837	1.000	1.000
581	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(10), GBA(3), MPO(8), PRDX6(1), TPO(11)	6371299	33	29	32	16	11	5	12	2	3	0	0.804	1.000	1.000
582	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(8), AGT(4), AGTR2(2), BDKRB2(3), KNG1(5), NOS3(4), REN(3)	6950425	29	28	29	16	5	7	9	3	5	0	0.839	1.000	1.000
583	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7)	6487339	30	28	30	11	6	6	8	9	1	0	0.632	1.000	1.000
584	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(7), ACO2(3), ACSS1(5), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(1)	10104755	32	28	32	16	3	10	11	2	6	0	0.865	1.000	1.000
585	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(2), FH(3), IDH2(1), MDH1(1), OGDH(11), SDHA(7), SUCLA2(1)	7148129	29	27	28	10	5	4	11	5	4	0	0.657	1.000	1.000
586	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR3(5), TOB2(3)	7155105	27	26	27	11	2	5	8	8	4	0	0.851	1.000	1.000
587	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4)	10028443	28	25	28	12	9	8	3	4	4	0	0.564	1.000	1.000
588	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(4), CDK4(5), CDKN1B(3), CFL1(2), E2F2(3), MDM2(2), PRB1(8)	5364510	27	25	27	11	1	7	10	5	4	0	0.804	1.000	1.000
589	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3)	6074660	25	24	25	11	4	2	9	6	4	0	0.853	1.000	1.000
590	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(3), ALDH9A1(3)	6074660	25	24	25	11	4	2	9	6	4	0	0.853	1.000	1.000
591	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4), VKORC1(2)	8415959	27	24	27	10	10	8	3	2	4	0	0.361	1.000	1.000
592	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(3), GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6)	7528437	26	24	26	13	5	6	7	4	4	0	0.819	1.000	1.000
593	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2)	9007518	30	24	30	11	0	11	10	5	4	0	0.716	1.000	1.000
594	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(2), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1)	10918791	26	24	26	16	6	8	5	2	5	0	0.893	1.000	1.000
595	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(3), FARS2(4), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7)	6306436	29	24	29	11	0	9	11	3	6	0	0.603	1.000	1.000
596	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	10	CDK5(3), CDK5R1(1), EGR1(4), KLK2(2), MAP2K1(5), MAP2K2(6), NGFR(2), RAF1(3)	5378267	26	23	26	12	8	4	8	2	4	0	0.597	1.000	1.000
597	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3D(1), GZMB(2), ICAM1(6), ITGAL(7), ITGB2(4), PRF1(4)	5900376	24	23	24	12	5	5	4	2	8	0	0.649	1.000	1.000
598	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), DHFR(3), FPGS(2), GGH(3)	4978860	25	23	25	11	3	2	13	3	4	0	0.769	1.000	1.000
599	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3)	7706334	25	22	25	14	4	6	8	1	6	0	0.893	1.000	1.000
600	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(4)	5101404	22	22	22	10	5	4	9	3	1	0	0.655	1.000	1.000
601	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1)	5385256	23	22	23	19	2	8	5	6	2	0	0.994	1.000	1.000
602	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(13), GLS(1), GLUD1(4), GOT1(1)	5928982	22	22	22	10	4	5	5	5	3	0	0.801	1.000	1.000
603	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	5250461	24	21	24	17	7	3	7	2	4	1	0.960	1.000	1.000
604	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(4), WASF1(3), WASL(2)	5844308	21	21	21	15	5	5	5	4	2	0	0.990	1.000	1.000
605	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(2), TGFB2(3), TGFB3(1)	6285319	23	20	23	12	6	2	8	5	2	0	0.882	1.000	1.000
606	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), NAT1(2), XDH(6)	6066385	23	20	23	13	3	5	9	4	2	0	0.906	1.000	1.000
607	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(5), CPO(4), FECH(1), HBA2(2), UROD(1), UROS(4)	5939473	19	19	19	11	2	3	7	6	1	0	0.947	1.000	1.000
608	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(2), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), IL9(2)	4619492	18	18	18	10	4	3	6	3	2	0	0.888	1.000	1.000
609	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2)	12617181	18	17	18	10	0	4	5	5	4	0	0.957	1.000	1.000
610	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(6), BIRC3(2), FADD(4), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	5518937	20	17	20	10	5	5	6	3	1	0	0.735	1.000	1.000
611	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4)	6712693	19	16	19	10	3	6	5	2	3	0	0.957	1.000	1.000
612	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4)	2979765	16	16	16	7	1	6	4	5	0	0	0.692	1.000	1.000
613	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4)	6833447	17	16	17	11	3	2	4	4	4	0	0.969	1.000	1.000
614	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4)	3644574	16	15	16	7	3	3	7	3	0	0	0.695	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(6), SUCLA2(1)	1601806	7	7	7	4	0	2	4	1	0	0	0.831	1.000	1.000
616	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(2), CFL1(2), CFLAR(2)	2059462	7	7	7	5	2	5	0	0	0	0	0.743	1.000	1.000
