rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(1), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4)	5419468	15	15	14	0	3	2	4	5	0	1	0.00868	0.0476	1.000
2	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(3), GOT2(2), TAT(2), TYR(5)	4732052	15	15	15	1	2	1	3	4	5	0	0.149	0.0661	1.000
3	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(3), EHHADH(6), HADHA(4)	4888973	15	15	14	1	1	3	4	4	3	0	0.0385	0.0777	1.000
4	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(1), HLA-DRA(1), HLA-DRB1(6)	1241979	8	7	8	2	1	3	1	1	2	0	0.501	0.0842	1.000
5	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLS(7), OAT(2), PRODH(4)	5565788	16	16	16	1	1	3	5	4	3	0	0.0626	0.0943	1.000
6	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PDXK(3), PDXP(2), PSAT1(2)	4789589	15	14	15	1	3	1	1	6	4	0	0.127	0.108	1.000
7	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(4), SHMT1(2), SHMT2(5)	4094910	14	14	14	2	1	1	4	5	3	0	0.253	0.118	1.000
8	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(9), KARS(1)	4802785	15	15	15	2	0	3	3	4	5	0	0.276	0.125	1.000
9	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(2), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(7), ITGB2(2), PRF1(1)	8328704	26	24	26	2	2	6	3	10	4	1	0.0199	0.131	1.000
10	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(5), AASDHPPT(3), AASS(9), KARS(1)	7059407	20	20	20	2	0	4	4	6	6	0	0.133	0.133	1.000
11	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4)	8443021	21	21	20	1	1	4	5	8	3	0	0.0143	0.188	1.000
12	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(6), GLS(7), GOT1(3)	7769460	21	21	21	2	0	4	2	9	6	0	0.148	0.256	1.000
13	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(10), ERBB3(8), NRG1(6), UBE2D1(2)	10301766	31	31	29	4	5	3	4	11	8	0	0.106	0.262	1.000
14	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(2)	2651351	7	7	7	1	1	1	2	0	3	0	0.424	0.275	1.000
15	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL3(1)	2792284	10	9	10	2	0	3	2	2	3	0	0.450	0.309	1.000
16	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(7), EGF(5), EGFR(10), HGS(3), RAB5A(1), TFRC(3)	12803255	29	28	27	0	5	1	6	9	8	0	0.00152	0.310	1.000
17	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	9	ACAT1(1), ACYP1(1), ECHS1(3), EHHADH(6), HADHA(4), SDHB(1)	6937189	16	16	15	1	1	3	4	6	2	0	0.0421	0.315	1.000
18	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	513607	1	1	1	1	0	0	0	0	1	0	1.000	0.349	1.000
19	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	1171958	4	3	4	0	0	1	1	1	1	0	0.376	0.351	1.000
20	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(3), RAB3A(2), RAB4A(1), RAB5A(1), RAB6A(1)	4248633	10	10	10	1	1	1	2	3	3	0	0.261	0.352	1.000
21	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), GBA3(3), LPO(1), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TPO(4), TYR(5)	9594681	28	27	28	4	2	2	10	9	5	0	0.120	0.370	1.000
22	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(2), MECR(4), PPT1(1)	8470284	19	18	19	1	2	3	6	7	1	0	0.0185	0.377	1.000
23	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(5), MYC(2), SP1(2), SP3(2), WT1(3)	6102798	16	16	16	2	0	1	0	8	7	0	0.476	0.433	1.000
24	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(1), CD28(1), CD3E(2), CD3G(2)	2342928	6	5	6	1	1	1	1	2	1	0	0.451	0.450	1.000
25	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD2(2), CD34(2), CD3E(2), CD3G(2), CD58(1), CD8A(1), IL3(1), KITLG(2)	5333673	13	11	13	1	1	2	2	5	3	0	0.203	0.496	1.000
26	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	GBA(3), GBA3(3), GGT1(4), SHMT1(2), SHMT2(5)	4912337	17	17	17	4	1	1	4	8	3	0	0.470	0.515	1.000
27	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(3), CSF1R(8), EGF(5), EGFR(10), GRB2(2), PDGFRA(8), PRKCA(2), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(4)	16619090	49	43	47	5	4	9	6	17	13	0	0.0142	0.535	1.000
28	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	726871	1	1	1	1	0	0	1	0	0	0	0.957	0.541	1.000
29	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(2), COQ7(1), NDUFA13(2), NDUFB11(1)	4130964	8	8	8	1	3	1	0	3	1	0	0.334	0.543	1.000
30	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(1)	1538815	3	3	3	1	0	0	0	3	0	0	0.815	0.545	1.000
31	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	1715205	5	5	5	2	1	1	1	2	0	0	0.717	0.555	1.000
32	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), NDUFA1(1), SDHA(9), SDHB(1), SDHD(2), UQCRC1(1)	6536667	18	16	18	3	3	7	3	5	0	0	0.101	0.575	1.000
33	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL4(1)	2846625	10	9	10	3	2	3	2	1	2	0	0.504	0.579	1.000
34	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(3), ITGAL(7), ITGAM(9), ITGB2(2), SELE(6), SELL(2)	10626766	32	32	32	5	3	9	6	8	6	0	0.0562	0.593	1.000
35	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(3), ATM(20), BAX(1), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIF1A(4), IGFBP3(1), NFKBIB(2)	19418629	47	42	43	4	3	4	5	16	17	2	0.0205	0.604	1.000
36	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(5), ENO2(2), ENO3(2), GOT1(3), GOT2(2), PAH(6), TAT(2), YARS(1)	8346172	23	21	23	3	2	2	6	6	7	0	0.122	0.605	1.000
37	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(5), AKT3(3), CDKN1A(3), ELK1(1), GRB2(2), HRAS(1), MAP2K2(1), NGFR(1), NTRK1(8), PIK3CD(2), SHC1(4), SOS1(9)	13672505	43	40	42	6	4	7	4	21	6	1	0.0420	0.609	1.000
38	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(2), NTAN1(1), SIRT1(6), SIRT5(1), SIRT7(2), VNN2(1)	11898675	29	27	28	4	3	6	6	6	8	0	0.0501	0.611	1.000
39	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	ABO(1), B3GNT1(2), FUT1(1), FUT2(2), ST8SIA1(2)	3832795	8	8	8	1	3	1	0	3	1	0	0.279	0.612	1.000
40	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(2), CD3G(2), CD8A(1), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	10584486	28	25	28	4	3	5	3	11	6	0	0.104	0.651	1.000
41	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	9	ACACA(8), CPT1A(2), LEP(1), LEPR(5), PRKAA1(1), PRKAB1(1), PRKAG1(5), PRKAG2(6)	13517197	29	28	29	3	2	6	8	6	7	0	0.0161	0.677	1.000
42	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(2), CD28(1), CD3E(2), CD3G(2), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	10274303	27	25	27	4	3	4	3	11	6	0	0.139	0.685	1.000
43	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFA(1), DFFB(1), HMGB1(3), HMGB2(3), TOP2A(5), TOP2B(7)	10113287	21	20	21	2	3	3	2	6	6	1	0.181	0.695	1.000
44	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(5)	6194918	13	11	13	0	0	2	3	5	3	0	0.0167	0.706	1.000
45	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), FH(2), IDH1(2), IDH2(6), MDH1(2), MDH2(1), SDHB(1), SUCLA2(2)	8974879	21	20	18	3	1	3	1	7	9	0	0.210	0.709	1.000
46	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(3), SQLE(1)	4384154	8	8	8	1	1	1	0	4	2	0	0.494	0.710	1.000
47	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(4), CAMKK2(3), SYT1(1)	11606698	24	24	23	2	2	3	4	9	6	0	0.0623	0.713	1.000
48	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(3)	2260400	4	4	4	1	0	0	1	1	2	0	0.830	0.728	1.000
49	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(2), IL2RA(2), IL4(1), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TGFBR3(3), TOB1(5), TOB2(3)	10680453	26	25	26	4	1	4	6	10	5	0	0.151	0.741	1.000
50	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB1(4), ABCB11(4), ABCB4(8), ABCC3(11), GSTP1(2)	11495894	29	27	26	4	1	5	7	9	7	0	0.0848	0.741	1.000
51	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	3	RAN(2), RANGAP1(1)	1992979	3	3	3	1	0	2	0	0	1	0	0.749	0.750	1.000
52	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(3)	3085202	5	5	5	1	0	0	1	4	0	0	0.601	0.757	1.000
53	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(3), GOT2(2), LDHB(2), LDHC(3), MPST(2)	6773580	20	20	18	4	1	0	3	7	9	0	0.644	0.765	1.000
54	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(7), POLG(6), PRPS2(4), RRM1(3)	12380440	29	28	27	3	2	5	2	11	9	0	0.0886	0.768	1.000
55	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), GSR(1), GSS(1), NFKB1(2), NOX1(7), RELA(6), TNF(1), XDH(7)	9878723	27	24	22	3	1	3	6	6	10	1	0.193	0.769	1.000
56	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(7), HEXA(4), IDS(2), IDUA(6), LCT(7), NAGLU(2)	14285623	44	37	39	7	7	5	6	17	9	0	0.0740	0.777	1.000
57	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(1), PTK2B(3), SHC1(4), SOS1(9), SRC(4)	8688524	24	22	24	4	1	8	2	8	5	0	0.172	0.777	1.000
58	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(3), MTMR6(1), NFS1(2), PHPT1(1), THTPA(1), TPK1(2)	6441584	12	12	12	2	2	2	2	6	0	0	0.290	0.789	1.000
59	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(3), IFNGR2(2), JAK1(7), JAK2(7), STAT1(6)	8316258	25	25	25	5	3	0	3	14	5	0	0.496	0.800	1.000
60	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(2)	4231158	13	12	13	4	1	4	3	1	4	0	0.646	0.804	1.000
61	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(4), PPP1R1B(1)	3691951	7	7	7	2	1	1	1	3	1	0	0.649	0.824	1.000
62	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(2)	6105520	22	20	22	6	4	5	4	7	2	0	0.233	0.826	1.000
63	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1)	10131170	19	17	19	2	2	3	3	5	6	0	0.134	0.834	1.000
64	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(1)	3294606	5	5	5	1	0	1	0	2	2	0	0.743	0.835	1.000
65	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(1), RDH11(4), RDH13(1)	4715015	9	9	9	2	2	0	1	6	0	0	0.496	0.839	1.000
66	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(3), EGF(5), EGFR(10), GRB2(2), HRAS(1), MAPK3(3), PTPRB(5), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SPRY1(1), SPRY2(3), SRC(4)	24503919	61	54	59	7	4	15	9	19	14	0	0.00762	0.840	1.000
67	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(1), ARF3(3), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CFL1(1), E2F1(1), E2F2(1)	6289236	19	19	16	5	0	0	3	5	10	1	0.874	0.845	1.000
68	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELE(6), SELL(2)	12218157	33	32	33	6	2	9	7	8	7	0	0.131	0.848	1.000
69	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(3), ALDOB(3), ALDOC(1), TPI1(2)	3865278	9	9	9	5	0	0	3	1	5	0	0.982	0.848	1.000
70	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	2032463	2	2	2	1	0	0	0	1	1	0	0.774	0.872	1.000
71	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(3), UGDH(1), UXS1(1)	3998272	7	7	7	2	0	1	3	3	0	0	0.598	0.874	1.000
72	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(22), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAR2A(1), PRKAR2B(3), PRKCE(4)	18075505	49	46	46	7	6	3	3	21	15	1	0.0990	0.876	1.000
73	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(3), F2(4), F2R(2), FGA(4), FGB(2), FGG(6), PLAT(4), PLAU(5), PLG(8), SERPINB2(1)	13504810	45	42	40	9	6	4	5	19	11	0	0.220	0.882	1.000
74	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(3), WEE1(2)	7392778	11	10	11	1	0	2	0	5	3	1	0.314	0.883	1.000
75	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(4), HSD17B1(1), HSD17B2(1), HSD17B4(2), HSD17B7(1), HSD3B1(1)	8078703	13	12	13	2	2	3	3	4	1	0	0.209	0.906	1.000
76	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(3), HTR2C(1), PLCB1(4), TUB(4)	7113832	14	13	14	2	1	2	0	10	1	0	0.283	0.906	1.000
77	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25A(1), CDC25B(1), CDC25C(3), MNAT1(1), SHH(3), XPO1(8)	8685207	19	19	19	4	1	2	7	7	2	0	0.275	0.912	1.000
78	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(3), UGDH(1), UGP2(1), UXS1(1)	5057310	8	8	8	2	0	1	4	3	0	0	0.496	0.913	1.000
79	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1643608	1	1	1	0	0	0	0	1	0	0	0.838	0.915	1.000
80	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3)	3068084	3	3	3	1	0	1	0	2	0	0	0.830	0.916	1.000
81	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(1)	8675384	20	19	19	4	2	2	4	2	8	2	0.461	0.919	1.000
82	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(6), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HSD17B7(1), IDI1(1), IDI2(3), LSS(4), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1), TM7SF2(3), VKORC1(1)	19285921	38	35	36	2	2	6	2	17	11	0	0.0124	0.922	1.000
83	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(5), AKT3(3), GRB2(2), ILK(4), MAPK3(3), PDK1(1), PIK3CD(2), PTK2B(3), RBL2(5), SHC1(4), SOS1(9)	17214478	44	40	42	5	6	8	5	15	10	0	0.0238	0.929	1.000
84	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(2), FDPS(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), SC5DL(1), SQLE(1), VKORC1(1)	11094202	17	17	17	1	0	3	2	8	4	0	0.0993	0.930	1.000
85	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(5), GPRC5A(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM1(5), GRM2(5), GRM3(5), GRM4(6), GRM5(9), GRM7(5), GRM8(4)	19738245	55	48	52	9	9	9	5	20	12	0	0.0552	0.933	1.000
86	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(1), NDUFV1(2), NDUFV2(1)	7042130	24	24	23	7	0	1	3	11	9	0	0.808	0.942	1.000
87	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5)	5259683	13	13	13	4	2	1	2	4	3	1	0.702	0.944	1.000
88	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), FH(2), IDH2(6), MDH1(2), OGDH(8), SDHA(9), SUCLA2(2)	9450965	31	28	28	7	1	9	0	11	10	0	0.329	0.944	1.000
89	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCS1(2), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1), SC4MOL(1), SC5DL(1), SQLE(1)	13226697	23	20	23	1	0	5	2	9	7	0	0.0407	0.945	1.000
90	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2N(3), UBE3A(2)	10471665	19	19	19	3	1	2	2	9	5	0	0.296	0.945	1.000
91	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	HRAS(1), MMP14(1), MMP2(7), MMP9(1), RECK(1), TIMP2(1)	7118269	12	12	12	3	2	3	1	3	3	0	0.454	0.948	1.000
92	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(4), APEX1(2), CREBBP(10), DFFA(1), DFFB(1), HMGB2(3), PRF1(1)	10462724	22	21	22	4	4	4	5	3	6	0	0.110	0.951	1.000
93	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), SELE(6), SELL(2), SELP(2)	16189587	44	42	44	9	3	11	9	12	9	0	0.144	0.952	1.000
94	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(4), STX1A(1), VAMP2(1)	3211172	8	7	8	4	0	1	0	4	3	0	0.913	0.957	1.000
95	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3)	17543882	46	43	45	7	6	4	8	18	10	0	0.0919	0.958	1.000
96	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), CAMP(1), DAG1(3), ITPKA(2), ITPKB(2)	5726775	11	10	11	3	2	1	2	1	5	0	0.736	0.961	1.000
97	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	7	ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), MIOX(2), UGDH(1)	6548226	11	11	11	3	1	1	3	4	2	0	0.571	0.965	1.000
98	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(8), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	15076622	40	38	40	8	5	6	3	16	10	0	0.260	0.966	1.000
99	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(3), GAD1(2), GAD2(2), GGT1(4)	5683713	13	13	13	4	2	2	5	2	2	0	0.505	0.967	1.000
100	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(1), ATG3(2), ATG7(6), BECN1(2), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(1), ULK1(2), ULK2(3), ULK3(3)	20079890	45	43	45	7	4	4	4	24	9	0	0.149	0.968	1.000
101	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(1), FUT2(2), FUT3(2), FUT6(4), ST3GAL3(3)	4672695	13	12	11	4	5	1	0	3	4	0	0.692	0.968	1.000
102	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(2), CD3G(2), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(8), ZAP70(1)	7855602	23	20	23	5	1	5	2	9	6	0	0.428	0.969	1.000
103	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(7), MST1R(4), TNF(1)	6032580	14	14	12	4	1	1	5	2	5	0	0.756	0.970	1.000
104	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), BCMO1(1), RDH5(4)	3854221	7	7	7	3	0	0	5	1	1	0	0.790	0.972	1.000
105	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(2), CYP17A1(3), HSD11B2(1), HSD3B1(1)	6759353	11	9	11	2	1	0	1	9	0	0	0.380	0.973	1.000
106	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(6), IL3(1), IL9(1), KITLG(2), TGFB2(3), TGFB3(1)	8353125	15	15	15	3	0	1	3	7	4	0	0.583	0.973	1.000
107	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(7), GLS2(4), GLUD2(7)	4425638	18	18	16	5	1	2	3	10	2	0	0.611	0.973	1.000
108	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), DCXR(1), GUSB(7), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4)	17550099	42	37	40	7	3	6	11	10	12	0	0.114	0.975	1.000
109	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), KERA(1), LUM(1)	3580606	8	8	8	3	0	1	0	5	2	0	0.790	0.976	1.000
110	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(2), GNAS(5), GNB1(3), PPP2CA(1), PRKAA1(1), PRKAB1(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAG2(6), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	14024223	38	38	38	7	5	3	2	18	10	0	0.237	0.977	1.000
111	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(3), IFNB1(3), JAK1(7), STAT1(6), STAT2(6), TYK2(7)	10778339	34	29	33	8	4	7	4	9	10	0	0.241	0.979	1.000
112	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(2), CD80(1), CD86(3), CTLA4(3), GRB2(2), HLA-DRA(1), HLA-DRB1(6), ICOS(3), ITK(2), LCK(1), PIK3R1(5), PTPN11(2)	10445296	34	32	33	7	4	8	3	9	10	0	0.407	0.981	1.000
113	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	8049816	14	14	14	4	0	4	4	4	2	0	0.529	0.982	1.000
114	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(1), OXCT1(2)	3424685	4	4	4	2	0	1	0	2	1	0	0.869	0.983	1.000
115	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(8), CCNE1(3), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(1)	8733824	24	23	21	5	2	3	4	3	10	2	0.389	0.984	1.000
116	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), PKM2(1), RPE(2), RPIA(2), TKT(2), TKTL1(2), TKTL2(6), TPI1(2)	19919703	47	46	47	8	2	5	8	15	17	0	0.190	0.986	1.000
117	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(13), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	12685957	36	35	35	8	10	2	4	14	6	0	0.209	0.987	1.000
118	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5)	13160936	36	35	33	7	4	5	6	10	11	0	0.209	0.987	1.000
119	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), PKM2(1), RPE(2), RPIA(2), TKT(2), TPI1(2)	17800341	41	39	41	7	2	5	8	10	16	0	0.199	0.988	1.000
120	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNGR1(3), JAK1(7), JAK2(7), PTPRU(5), STAT1(6)	11401408	30	28	30	6	4	0	3	18	5	0	0.421	0.989	1.000
121	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(8), CCNE1(3), CCNE2(4), CDK2(2), CDK4(6), CDKN1B(1), E2F1(1), E2F2(1)	7808941	26	21	19	5	1	3	4	4	14	0	0.459	0.989	1.000
122	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(3), IL10RA(4), JAK1(7), STAT1(6), STAT3(3), STAT5A(3), TNF(1)	12086486	28	28	27	5	4	0	1	13	10	0	0.587	0.989	1.000
123	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(5), GNB1(3), PRKACA(2), PRKAR1A(2)	6330917	14	14	14	4	2	1	1	9	1	0	0.732	0.989	1.000
124	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDK2(2), CUL1(5), E2F1(1), FBXW7(6), RB1(4)	8487807	21	20	21	5	2	3	5	2	7	2	0.503	0.990	1.000
125	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(4), NOS3(4), REN(1)	9667579	25	24	23	5	2	4	3	10	6	0	0.298	0.990	1.000
126	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(3), DHRS2(1), PON2(2), PON3(5), RDH11(4), RDH13(1)	8273385	16	16	15	4	3	0	3	7	3	0	0.610	0.990	1.000
127	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(3), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL6(1), FADS1(1), FADS2(2), FASN(9), HADHA(4), PECR(4)	13539916	32	26	32	5	4	8	2	16	2	0	0.0445	0.991	1.000
128	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4)	11705473	30	29	30	6	2	3	9	10	6	0	0.264	0.991	1.000
129	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(3), ENO1(5), HK1(5), PFKL(3), PGAM1(1), PGK1(3), PKLR(1), TPI1(2)	7884201	23	21	23	7	4	3	3	7	6	0	0.475	0.991	1.000
130	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CCL2(1), LDLR(3), LPL(3)	5223024	8	8	8	3	0	3	0	4	1	0	0.679	0.992	1.000
131	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	ABO(1), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), FUT1(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), ST3GAL6(1), ST8SIA1(2)	13051506	29	27	28	5	7	4	3	8	7	0	0.185	0.993	1.000
132	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(4), F2R(2), F5(12), F7(1), FGA(4), FGB(2), FGG(6), PROC(4), PROS1(5), TFPI(2)	16338029	43	41	41	9	5	5	3	16	13	1	0.360	0.993	1.000
133	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	10	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4)	10211214	22	22	21	5	2	3	6	9	2	0	0.249	0.993	1.000
134	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(3), CTSD(3), GREB1(18), HSPB2(2), MTA1(4), MTA3(3), PDZK1(1)	10599857	34	31	31	8	1	2	7	17	7	0	0.605	0.994	1.000
135	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(5), AOC3(2), CES1(8), ESD(1)	5734455	21	20	19	6	0	3	4	9	5	0	0.553	0.994	1.000
136	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(6), C6(3), C7(4), C8A(1)	12856880	22	21	22	4	2	2	2	12	4	0	0.327	0.994	1.000
137	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(3), EPOR(3), GRIN1(2), HIF1A(4), JAK2(7), NFKB1(2), NFKBIA(2), RELA(6)	12667776	31	29	28	6	1	4	4	10	9	3	0.360	0.994	1.000
138	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), DNAJC3(2), EIF2S2(2), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6)	9173529	18	18	15	4	1	5	0	4	7	1	0.597	0.995	1.000
139	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(3), ATM(20), BAX(1), CCNE1(3), CDK2(2), CDK4(6), CDKN1A(3), E2F1(1), PCNA(4), RB1(4)	17036308	47	39	43	9	3	4	6	11	20	3	0.391	0.995	1.000
140	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(11), NRG2(4), NRG3(5), PRKCA(2)	9122312	24	24	24	6	3	5	3	10	3	0	0.421	0.995	1.000
141	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(3), GBA3(3), LPO(1), MPO(6), PRDX6(2), TPO(4)	8274972	22	21	22	5	2	2	7	8	3	0	0.336	0.996	1.000
142	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(5), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(2)	6617312	13	13	11	4	1	2	1	3	6	0	0.801	0.996	1.000
143	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(2), MUT(2)	4850611	5	5	5	2	1	0	1	1	2	0	0.890	0.996	1.000
144	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(2), GOT1(3), GOT2(2), PAH(6), TAT(2), YARS(1), YARS2(1)	8708104	17	17	17	4	1	1	4	5	6	0	0.607	0.996	1.000
145	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(4), SP1(2), SP3(2)	6742291	11	11	11	3	0	3	0	2	4	2	0.835	0.996	1.000
146	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(3), JAK1(7), PTPRU(5), STAT1(6), STAT2(6), TYK2(7)	12301259	37	32	36	9	5	5	4	13	10	0	0.299	0.996	1.000
147	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SRP19(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1)	7594500	11	10	11	3	1	3	2	5	0	0	0.504	0.997	1.000
148	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1)	23473829	54	50	50	8	5	7	4	24	14	0	0.0735	0.997	1.000
149	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1)	17963465	33	32	33	5	3	6	3	15	6	0	0.110	0.997	1.000
150	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(2), HDC(1), TH(4), TPH1(2)	5828899	11	11	11	4	2	2	3	2	2	0	0.692	0.998	1.000
151	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(1)	3849704	3	3	3	2	0	0	2	0	1	0	0.942	0.998	1.000
152	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT1(1), FUT2(2), FUT3(2), ST3GAL3(3), ST3GAL4(2)	6991590	18	17	16	6	6	0	2	3	7	0	0.769	0.998	1.000
153	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(3), IFNB1(3), NFKB1(2), RELA(6), TRAF6(2)	10827165	18	18	15	4	2	6	0	2	7	1	0.502	0.998	1.000
154	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(4), JAK1(7), JAK2(7), TYK2(7)	10359495	27	26	26	8	3	0	5	9	10	0	0.714	0.998	1.000
155	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(4), JAK1(7), JAK2(7), TYK2(7)	10359495	27	26	26	8	3	0	5	9	10	0	0.714	0.998	1.000
156	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(10), G6PD(2), GCLC(4), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GPX6(1), GSR(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(6), OPLAH(7), TXNDC12(1)	21902956	62	54	59	11	5	7	13	24	13	0	0.103	0.998	1.000
157	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(20), CDC25A(1), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(5), WEE1(2)	13884133	33	30	32	7	2	4	5	14	8	0	0.324	0.999	1.000
158	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD8A(1), IL3(1), IL4(1), IL9(1)	5091265	4	4	4	2	0	1	2	1	0	0	0.817	0.999	1.000
159	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	12849668	26	26	26	6	3	3	3	13	4	0	0.350	0.999	1.000
160	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	6	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3)	6000951	9	9	9	4	1	0	3	5	0	0	0.793	0.999	1.000
161	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	6	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3)	6000951	9	9	9	4	1	0	3	5	0	0	0.793	0.999	1.000
162	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(7), HEXA(4), HGSNAT(3), HPSE(3), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), IDUA(6), LCT(7), NAGLU(2), SPAM1(8)	20450039	65	54	60	13	11	8	8	27	11	0	0.0742	0.999	1.000
163	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), GNA12(1), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAR2A(1), PRKAR2B(3)	10017406	24	24	24	6	3	3	3	11	4	0	0.461	0.999	1.000
164	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(7), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(5), SOAT1(4)	13744220	37	32	35	8	2	3	8	14	10	0	0.329	0.999	1.000
165	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(1), ENPP1(4), ENPP3(2), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(7), NT5M(2), QPRT(1)	14586679	29	28	29	6	2	2	3	17	5	0	0.355	0.999	1.000
166	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(3), HDAC9(4), MEF2A(3), MEF2D(1)	8146447	14	14	13	4	2	1	2	3	6	0	0.590	0.999	1.000
167	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3)	5684384	11	11	10	6	1	0	0	8	2	0	0.972	0.999	1.000
168	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), INS(1), INSR(6), IRS1(5), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SLC2A4(3), SOS1(9), SRF(1)	22722897	60	56	58	11	8	12	6	21	13	0	0.0968	0.999	1.000
169	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	13478748	26	26	26	6	3	3	3	13	4	0	0.349	0.999	1.000
170	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(1), C1R(4), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1), MASP1(4), MASP2(1), MBL2(2)	19971730	36	34	36	6	6	5	3	16	6	0	0.120	0.999	1.000
171	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(8)	11734006	25	25	25	6	2	4	5	6	8	0	0.453	1.000	1.000
172	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(1), CNR2(3), MTNR1B(1), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), TBXA2R(4)	7363229	22	21	22	9	3	3	2	9	5	0	0.736	1.000	1.000
173	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(1), C1R(4), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1)	16103490	29	27	29	5	4	4	2	14	5	0	0.207	1.000	1.000
174	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(5), ACSS1(4), ACSS2(7), FH(2), IDH1(2), IDH2(6), MDH1(2), MDH2(1), SUCLA2(2)	13350534	37	31	33	9	1	6	3	11	15	1	0.556	1.000	1.000
175	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP2(1), ACP5(2), ACP6(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), PON2(2), PON3(5)	17063096	38	36	36	9	4	7	4	14	9	0	0.312	1.000	1.000
176	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), DLL1(1), FURIN(3), NOTCH1(12)	8454303	18	18	16	5	3	4	0	5	5	1	0.573	1.000	1.000
177	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), NFKBIA(2), PLCB1(4), PRKCA(2), RELA(6)	8271451	16	16	13	6	2	3	0	4	6	1	0.877	1.000	1.000
178	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(1), BAK1(1), BAX(1), BCL10(1), BCL2L11(1), BID(2), CASP8AP2(7), CASP9(2), CES1(8)	11444024	27	27	25	7	1	2	4	9	11	0	0.658	1.000	1.000
179	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(2), IL4(1), IL4R(4), IRS1(5), JAK1(7), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(5)	14280336	37	35	37	9	6	3	5	14	9	0	0.381	1.000	1.000
180	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4)	11498705	27	26	27	6	2	3	6	10	6	0	0.379	1.000	1.000
181	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13)	16460708	35	32	33	5	3	1	2	14	15	0	0.337	1.000	1.000
182	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(2)	13783530	32	30	32	8	3	3	4	13	9	0	0.493	1.000	1.000
183	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ARPC1B(2), CDC42(1), PAK1(3), PDGFRA(8), PIK3R1(5), RAC1(1), WASL(7)	10707213	29	27	29	8	3	5	1	14	6	0	0.675	1.000	1.000
184	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CSK(4), GRB2(2), PRKCA(2), PTPRA(5), SRC(4)	9194770	23	21	23	6	0	8	4	8	3	0	0.353	1.000	1.000
185	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR161(2), GPR171(1), GPR18(2), GPR39(2), GPR45(3), GPR65(5), GPR75(1)	9703900	17	17	17	5	3	4	0	7	2	1	0.309	1.000	1.000
186	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(3), PRKCA(2)	4863301	5	5	5	3	0	1	0	2	2	0	0.962	1.000	1.000
187	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(3), ALOX5(4), DPEP1(1), GGT1(4), LTA4H(4), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4)	15047940	37	34	34	9	4	5	9	10	8	1	0.314	1.000	1.000
188	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1)	8538360	17	17	17	5	1	1	1	8	6	0	0.804	1.000	1.000
189	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	6	CD36(1), FOS(1), FYN(2), JUN(2), MAPK14(1)	4844162	7	7	7	4	1	1	0	4	1	0	0.958	1.000	1.000
190	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(4), SULT1E1(2), SULT2A1(1), SUOX(4)	6145351	14	14	14	5	1	2	5	3	3	0	0.674	1.000	1.000
191	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	7686861	14	14	13	8	2	0	2	4	6	0	0.973	1.000	1.000
192	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(4)	12513657	30	28	30	9	5	4	2	11	8	0	0.585	1.000	1.000
193	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(2), MDH1(2), ME1(1), PC(8), PDHA1(1), SLC25A1(1), SLC25A11(1)	9156149	22	21	22	9	1	3	1	10	7	0	0.885	1.000	1.000
194	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(3), CSNK1A1(2), GSK3B(3), MAPT(4), PPP2CA(1)	9382975	14	13	12	8	0	1	2	2	9	0	0.987	1.000	1.000
195	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CTH(2), GGT1(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), PAPSS1(3), PAPSS2(4), SCLY(3), SEPHS1(1)	12160401	31	30	31	9	3	5	8	8	7	0	0.474	1.000	1.000
196	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(3), ENPP1(4), ENPP3(2), FLAD1(4), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5)	15026149	29	28	28	6	0	6	1	18	4	0	0.391	1.000	1.000
197	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	HLA-DRA(1), HLA-DRB1(6), IFNA1(2), IFNB1(3), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(3), TGFB3(1), TNF(1)	12046466	21	20	21	5	0	8	3	7	3	0	0.310	1.000	1.000
198	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(1), C1R(4), C2(2), C3(8), C5(6), C6(3), C7(4), C8A(1), C8B(2), MASP1(4)	19418108	35	33	35	6	7	4	2	16	6	0	0.152	1.000	1.000
199	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	27	AADAT(2), AASDH(5), AASDHPPT(3), AASS(9), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), BBOX1(2), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(9), HADHA(4), PLOD1(3), PLOD2(5), SHMT1(2), SHMT2(5), TMLHE(1)	31731546	82	74	80	14	8	13	13	31	17	0	0.0163	1.000	1.000
200	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	33	31	33	8	2	4	8	12	6	1	0.406	1.000	1.000
201	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	33	31	33	8	2	4	8	12	6	1	0.406	1.000	1.000
202	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	33	31	33	8	2	4	8	12	6	1	0.406	1.000	1.000
203	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(8), CCNB1(1), CCND2(1), CCNE1(3), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2C(1), E2F1(1), RB1(4)	15496110	34	29	28	9	2	3	4	7	15	3	0.696	1.000	1.000
204	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), PER1(6)	8447097	17	17	16	5	2	1	4	5	4	1	0.658	1.000	1.000
205	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(5), AOC2(5), AOC3(2), CES1(8), DDHD1(2), ESCO1(2), ESCO2(1), LIPA(1), MYST3(4), MYST4(3), PLA1A(3), PNPLA3(3), PRDX6(2), SH3GLB1(3)	25070993	45	40	43	6	2	5	7	18	13	0	0.0870	1.000	1.000
206	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(3), NR3C1(4), PPARG(2), RETN(1), TNF(1)	5591626	11	11	11	5	1	3	2	3	2	0	0.812	1.000	1.000
207	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	14	ACADL(3), ACADM(1), ACADS(3), ACSL1(4), ACSL4(1), CPT1A(2), CPT2(2), EHHADH(6), HADHA(4), PECR(4), SCP2(3)	15357545	33	32	31	9	2	8	7	11	4	1	0.269	1.000	1.000
208	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(3), BIRC3(5), CASP10(4), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(4), SREBF1(4), SREBF2(8)	17987606	38	37	38	8	1	7	7	13	10	0	0.277	1.000	1.000
209	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(4), EXT2(1), EXTL1(1), EXTL3(3), GLCE(5), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), NDST1(2), NDST2(4), NDST3(1), NDST4(7)	19663279	41	38	40	8	5	4	7	16	9	0	0.229	1.000	1.000
210	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), JUNB(3), MAF(2), MAP2K3(4), MAPK14(1), NFATC1(4), NFATC2(8), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	11365863	39	37	37	11	8	0	2	19	10	0	0.587	1.000	1.000
211	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(3)	6689394	11	11	10	7	1	3	1	2	4	0	0.973	1.000	1.000
212	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(1), HDAC5(3), MEF2A(3), MEF2D(1), PPP3CA(3), PPP3CC(3), SLC2A4(3), SYT1(1)	20534709	34	34	33	5	4	2	4	13	11	0	0.150	1.000	1.000
213	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(3), NR1H3(3), NR1H4(2)	5216943	8	8	8	5	0	3	0	4	1	0	0.886	1.000	1.000
214	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(20), ATR(12), CDC25C(3), CHEK1(1), CHEK2(2)	15303497	38	32	37	9	3	4	5	15	11	0	0.517	1.000	1.000
215	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(2), NFKB1(2), PLCG1(4), PRKCA(2), RELA(6)	20353047	47	41	41	9	5	5	5	18	13	1	0.325	1.000	1.000
216	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(1), CASP9(2), CHUK(2), GHR(1), NFKB1(2), NFKBIA(2), PIK3R1(5), PPP2CA(1), RELA(6)	12011022	25	25	22	6	2	5	1	8	8	1	0.545	1.000	1.000
217	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(3), FUT1(1), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST8SIA1(2)	10462880	18	17	18	5	5	3	2	7	1	0	0.337	1.000	1.000
218	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(9), GNAS(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1)	12776536	33	33	33	9	4	2	2	17	8	0	0.725	1.000	1.000
219	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(3), HLA-A(6), ITGB1(7), KLRC1(3), KLRC2(5), KLRC3(1), LAT(1), MAPK3(3), PAK1(3), PIK3R1(5), PTK2B(3), PTPN6(3), RAC1(1), SYK(2), VAV1(4)	16512172	50	42	49	11	3	8	6	15	17	1	0.495	1.000	1.000
220	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), ATIC(2), FTCD(2), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1)	19046794	36	35	36	8	3	6	3	18	6	0	0.360	1.000	1.000
221	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(3), CCNE1(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK3(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3R1(5), RAC1(1), RAF1(4), RB1(4), RELA(6)	18039064	51	42	45	11	5	5	5	14	18	4	0.613	1.000	1.000
222	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3)	15818456	17	16	17	3	1	2	4	7	3	0	0.332	1.000	1.000
223	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(2), PAPSS1(3), PAPSS2(4), SULT1A1(2), SULT1E1(2), SULT2A1(1), SUOX(4)	8895794	19	19	18	6	3	3	5	3	5	0	0.633	1.000	1.000
224	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(2), MAPK14(1), NFKB1(2), RELA(6), TNFRSF13B(1), TNFRSF17(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2)	14523652	25	24	22	5	0	6	0	8	10	1	0.590	1.000	1.000
225	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(6), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(6)	24821920	55	51	55	11	6	7	8	25	9	0	0.164	1.000	1.000
226	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2), P2RY6(2)	5565472	15	14	15	6	3	2	2	7	1	0	0.580	1.000	1.000
227	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP1(4), ENPP3(2), FLAD1(4), TYR(5)	9661735	19	18	19	5	0	4	0	11	4	0	0.646	1.000	1.000
228	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(3), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1)	9088362	15	14	15	7	1	0	2	8	4	0	0.838	1.000	1.000
229	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(3), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1)	9088362	15	14	15	7	1	0	2	8	4	0	0.838	1.000	1.000
230	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(1), EPOR(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(4), PTPN6(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3)	21357045	53	50	51	10	4	6	11	19	13	0	0.194	1.000	1.000
231	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(2), SNCAIP(4), UBE2E2(1), UBE2L3(1)	6336035	11	11	11	5	1	4	1	3	2	0	0.749	1.000	1.000
232	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF8(2)	13133143	25	24	23	6	2	7	3	5	8	0	0.371	1.000	1.000
233	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(6), CDKN1B(1), GRB2(2), ILK(4), ITGB1(7), MAPK3(3), PDK2(3), PIK3R1(5), PTK2(3), SHC1(4), SOS1(9)	16160917	50	43	48	12	5	7	4	18	15	1	0.572	1.000	1.000
234	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(1), OXCT1(2)	7281201	9	9	9	4	0	2	1	5	1	0	0.859	1.000	1.000
235	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(3), MPST(2), SULT1B1(2), SULT1C2(1), SULT1C4(3), SULT4A1(1)	12512961	31	31	29	8	2	1	5	12	11	0	0.760	1.000	1.000
236	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), FDXR(2), SHMT1(2)	16061007	35	33	35	9	2	4	8	14	6	1	0.449	1.000	1.000
237	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), NAT1(1), NAT2(2), XDH(7)	7901121	25	24	25	8	4	3	4	10	4	0	0.648	1.000	1.000
238	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPX1(2), PRKCE(4)	7712784	15	15	15	9	0	1	3	9	2	0	0.978	1.000	1.000
239	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(6), ARHGDIB(1), CASP1(3), CASP10(4), CASP8(1), CASP9(2), JUN(2), PRF1(1)	12699345	23	22	23	6	0	4	2	9	8	0	0.710	1.000	1.000
240	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(1), CD2(2), CD3E(2), CD3G(2), IL12RB1(4), IL12RB2(2), JAK2(7), STAT4(2), TYK2(7)	13853267	29	28	28	7	3	1	6	11	8	0	0.566	1.000	1.000
241	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	22	ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), FN3K(1), HADHA(4), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3), YOD1(2)	24267951	37	36	36	6	2	5	8	13	9	0	0.139	1.000	1.000
242	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(2), AKT1(3), ANXA1(1), CALM2(1), GNAS(5), GNB1(3), NFKB1(2), NOS3(4), NPPA(1), NR3C1(4), PIK3R1(5), RELA(6), SYT1(1)	15525528	38	36	35	9	5	7	3	14	8	1	0.551	1.000	1.000
243	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ABP1(5), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), DDC(3), EPX(3), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TAT(2), TPO(4)	20698523	55	49	54	12	8	6	14	16	11	0	0.148	1.000	1.000
244	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(3), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), CHST1(2), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	11591238	26	25	25	9	4	4	2	6	10	0	0.749	1.000	1.000
245	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST8SIA1(2)	5420228	11	11	11	6	1	2	1	6	1	0	0.798	1.000	1.000
246	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2)	6037936	11	11	11	7	3	3	0	4	1	0	0.806	1.000	1.000
247	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2)	6037936	11	11	11	7	3	3	0	4	1	0	0.806	1.000	1.000
248	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(1), ADSL(3), AGXT(2), AGXT2(2), ASL(4), ASNS(2), ASPA(1), CAD(13), CRAT(3), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), PC(8)	25927610	61	54	57	11	2	7	11	14	26	1	0.232	1.000	1.000
249	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), ATF3(1), EIF4E(2), EIF4EBP1(1), IFRD1(1), IL1R1(3), NR4A3(2), WDR1(2)	10856714	17	17	17	5	1	4	4	5	3	0	0.570	1.000	1.000
250	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2C1(5), MANBA(2), NEU1(1)	16037207	28	27	28	7	4	4	3	13	4	0	0.432	1.000	1.000
251	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(3), RPN2(1), UBE2A(2), UBE3A(2)	13232474	24	24	24	7	1	2	2	11	8	0	0.756	1.000	1.000
252	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	10	AHCY(5), BHMT(7), CTH(2), DNMT3B(3), MARS(3), MARS2(4), MAT1A(1), MAT2B(1)	12279257	26	25	26	8	1	5	5	10	5	0	0.668	1.000	1.000
253	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(5), XPO1(8)	9349842	21	21	21	6	5	1	4	7	4	0	0.676	1.000	1.000
254	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), CS(2), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), PC(8), PCK1(5), SDHA(9), SDHB(1), SUCLA2(2), SUCLG1(5), SUCLG2(2)	20569521	61	54	58	15	3	10	7	22	18	1	0.368	1.000	1.000
255	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(3), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(1), PCYT1B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3)	13882855	25	23	25	6	1	2	4	9	9	0	0.580	1.000	1.000
256	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(3), BFAR(2), BRAF(4), CAMP(1), CREB3(2), CREB5(3), RAF1(4), SNX13(4), SRC(4)	11545453	27	23	27	8	2	6	6	9	3	1	0.534	1.000	1.000
257	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(3), MYC(2), NFKB1(2), NFKBIA(2), PLCB1(4), PRKCA(2), RAF1(4), RELA(6), TNF(1)	15171285	32	31	29	8	6	3	2	11	9	1	0.561	1.000	1.000
258	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(1), EGFR(10), ELK1(1), GNAS(5), GNB1(3), GRB2(2), HRAS(1), IGF1R(3), ITGB1(7), KLK2(1), MAP2K2(1), MAPK3(3), MKNK1(2), MKNK2(1), MYC(2), NGFR(1), PDGFRA(8), PPP2CA(1), PTPRR(5), RAF1(4), RPS6KA5(2), SHC1(4), SOS1(9), SRC(4), STAT3(3)	31290010	84	71	82	17	8	14	8	35	19	0	0.147	1.000	1.000
259	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(6), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF5(3), GSK3B(3), PPP1CA(1)	11555478	22	21	20	8	2	1	5	6	8	0	0.816	1.000	1.000
260	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(5), GNB1(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2)	9484817	27	26	27	8	4	3	0	15	5	0	0.723	1.000	1.000
261	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(2), IFNB1(3), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TGFB2(3), TGFB3(1), TNF(1), TRAF6(2)	29600469	64	58	60	11	8	15	1	21	17	2	0.0982	1.000	1.000
262	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	23	ABAT(1), ABP1(5), ACADM(1), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(2), CNDP1(5), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HIBCH(1), MLYCD(3), SMS(2), UPB1(2)	24733871	61	57	60	14	4	7	16	20	13	1	0.149	1.000	1.000
263	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(4), FYN(2), ITGA1(8), ITGB1(7), L1CAM(5), LYN(1), SELP(2)	15696413	32	30	30	9	4	5	2	13	8	0	0.621	1.000	1.000
264	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	22	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), ASPA(1), CNDP1(5), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(2), MAOA(2), MAOB(2), PRPS1(1), PRPS2(4)	22271246	51	47	50	11	6	8	9	21	7	0	0.115	1.000	1.000
265	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(3), EGF(5), EGFR(10), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(7), JUN(2), MAP3K1(8), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1), STAT1(6), STAT3(3), STAT5A(3)	35212701	91	81	87	17	10	13	8	31	29	0	0.184	1.000	1.000
266	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	DPM2(1), HRAS(1), KLK2(1), MAP2K2(1), MAPK3(3), NGFR(1), RAF1(4)	7021019	12	12	12	5	1	1	2	7	1	0	0.851	1.000	1.000
267	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), JUN(2), KEAP1(3), MAPK14(1), PRKCA(2)	7538032	9	9	9	8	1	1	2	3	2	0	0.989	1.000	1.000
268	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR7(1), CD28(1), CXCR4(1), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL4(1), IL4R(4), TGFB2(3), TGFB3(1)	19119987	30	28	30	7	5	1	4	14	6	0	0.344	1.000	1.000
269	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	7316523	15	14	15	8	3	0	5	6	1	0	0.913	1.000	1.000
270	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(5), PLCE1(6), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAP2B(2)	14475925	31	31	31	9	4	3	3	13	8	0	0.693	1.000	1.000
271	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(2), BAD(1), BRAF(4), CREB3(2), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(4), EIF4E(2), GRB2(2), MAP2K2(1), MAP3K8(1), MAPK3(3), MKNK1(2), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA3(3), SHC1(4), SOS1(9), SOS2(7), TRAF3(1)	28001669	61	56	61	12	6	11	14	20	9	1	0.0682	1.000	1.000
272	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACOT11(2), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), HADHA(4), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3), YOD1(2)	28215869	44	42	43	8	3	5	10	16	10	0	0.119	1.000	1.000
273	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(1), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(3), PIK3R1(5), PPP2CA(1), RPS6KB1(2), TSC1(6), TSC2(13)	24719664	64	58	62	13	6	9	8	22	17	2	0.179	1.000	1.000
274	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(2), IKBKAP(2), IKBKB(3), IKBKG(1), MAP3K1(8), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), TNFAIP3(2), TRAF3(1), TRAF6(2)	18573647	33	31	30	7	2	8	0	9	13	1	0.499	1.000	1.000
275	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NEU1(1)	19751506	31	29	31	7	5	4	4	14	4	0	0.299	1.000	1.000
276	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(7), FYN(2), LRP8(4), RELN(7), VLDLR(4)	14040613	24	23	19	7	2	5	0	6	11	0	0.905	1.000	1.000
277	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(2), APC(9), AXIN1(5), BTRC(2), CTNNB1(2), DLL1(1), DVL1(1), FZD1(4), GSK3B(3), NOTCH1(12), WNT1(2)	20334446	43	41	40	10	6	6	3	17	10	1	0.364	1.000	1.000
278	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(3), CASP9(2), DAXX(6), FAS(2), FASLG(3), HSPB2(2), MAPKAPK2(1), TNF(1)	10996543	21	19	21	6	2	5	2	7	5	0	0.599	1.000	1.000
279	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(2), CREBBP(10), EP300(16), MAP3K7(3), MAPK3(3), SKIL(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2)	25692930	52	48	49	10	3	6	10	20	12	1	0.140	1.000	1.000
280	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(1), ACTR2(2), ARPC1B(2), CDC42(1), RAC1(1), WASF1(1), WASL(7)	7505962	15	15	15	6	1	5	0	9	0	0	0.795	1.000	1.000
281	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(3), IL15(1), IL16(5), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1)	9777111	16	16	16	6	0	7	2	6	1	0	0.619	1.000	1.000
282	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3)	14109858	21	19	21	5	1	2	5	6	7	0	0.481	1.000	1.000
283	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(1), CHRNB1(4), MUSK(4), PIK3R1(5), PTK2(3), PTK2B(3), RAPSN(1), SRC(4), TERT(10)	14173411	38	35	38	10	5	11	2	14	6	0	0.376	1.000	1.000
284	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	13	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1)	11420473	20	20	19	8	2	0	2	13	3	0	0.879	1.000	1.000
285	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(3), AKT2(5), AKT3(3), BAD(1), GRB2(2), GSK3A(3), GSK3B(3), IL4R(4), IRS1(5), JAK1(7), JAK3(4), MAP4K1(5), MAPK3(3), PDK1(1), PIK3CD(2), PIK3R1(5), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(9), SOS2(7), STAT6(5)	32874411	89	76	87	18	12	11	17	31	18	0	0.0612	1.000	1.000
286	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(3), GLI2(4), GLI3(7), GSK3B(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SHH(3), SMO(4), SUFU(3)	15784321	44	39	41	12	5	5	3	17	14	0	0.596	1.000	1.000
287	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(3), MYL2(1), MYLK(4), PLCB1(4), PPP1R12B(2), PRKCA(2), ROCK1(5)	20532945	34	34	34	8	3	2	2	19	8	0	0.513	1.000	1.000
288	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2H4(1), GTF2I(4), GTF2IRD1(2), STON1(3), TAF1(8), TAF10(1), TAF13(1), TAF1L(10), TAF2(6), TAF4(7), TAF4B(8), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(7), TAF9B(2), TBPL2(1)	36296949	84	75	80	16	5	13	13	33	20	0	0.0493	1.000	1.000
289	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), EGFR(10), IGF1R(3), MYC(2), POLR2A(13), PPP2CA(1), PRKCA(2), RB1(4), TEP1(9), TERF1(2), TERT(10), TNKS(6), XRCC5(4)	27088863	69	58	66	16	11	13	6	22	15	2	0.151	1.000	1.000
290	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), DCXR(1), GUSB(7), RPE(2), UGDH(1), UGP2(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), XYLB(2)	27074632	63	57	61	14	5	7	15	19	17	0	0.264	1.000	1.000
291	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(10), G6PD(2), GCLC(4), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), IDH2(6)	18274417	50	45	47	12	4	6	11	19	10	0	0.376	1.000	1.000
292	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	34	ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(1), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3)	34272304	70	68	68	14	5	10	15	28	11	1	0.0850	1.000	1.000
293	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), BAD(1), CASP9(2), CDC42(1), CHUK(2), ELK1(1), HRAS(1), MAPK3(3), NFKB1(2), PIK3R1(5), RAC1(1), RAF1(4), RALA(2), RALBP1(2), RELA(6)	16990469	36	35	32	9	2	6	3	13	11	1	0.669	1.000	1.000
294	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(4), FH(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PDK1(1), PDK2(3), PDK3(2), PDK4(1), PDP2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(5), SUCLG2(2)	28412255	77	65	74	18	3	15	9	26	23	1	0.242	1.000	1.000
295	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(5), IMPA1(1), PGM1(1)	10177273	9	8	9	7	3	0	0	4	2	0	0.963	1.000	1.000
296	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2)	9864830	16	16	16	7	3	2	1	8	2	0	0.735	1.000	1.000
297	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), AXIN1(5), BTRC(2), CREBBP(10), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(2), DVL1(1), FZD1(4), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(2), NLK(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2)	29096292	66	57	60	14	7	6	7	23	22	1	0.231	1.000	1.000
298	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), CAD(13), CPS1(6), EPRS(5), GAD1(2), GAD2(2), GCLC(4), GFPT1(3), GLS(7), GLS2(4), GLUL(2), GMPS(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(1)	33229940	69	60	65	13	5	9	12	25	17	1	0.162	1.000	1.000
299	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(3), CALCRL(2), CD97(6), CRHR1(2), CRHR2(3), ELTD1(4), EMR1(2), EMR2(4), GIPR(2), GLP1R(3), GLP2R(3), GPR64(3), LPHN1(5), LPHN2(4), LPHN3(10), SCTR(1), VIPR1(1), VIPR2(2)	27394928	62	54	61	14	11	7	10	24	10	0	0.156	1.000	1.000
300	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(2), CD3E(2), CD3G(2), CREBBP(10), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1)	21399940	59	53	59	14	6	9	5	27	12	0	0.327	1.000	1.000
301	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(2), CD3E(2), CD3G(2), CREBBP(10), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1)	21399940	59	53	59	14	6	9	5	27	12	0	0.327	1.000	1.000
302	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(3), AARS2(3), ABAT(1), ACY3(1), ADSL(3), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(2), ASPA(1), ASS1(3), CAD(13), CRAT(3), DARS(3), DARS2(1), DDO(1), DLAT(2), DLD(4), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1)	37075490	88	73	84	16	5	10	15	25	31	2	0.107	1.000	1.000
303	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(7), JUN(2), MAP3K1(8), MAPK3(3), PDGFRA(8), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1), STAT1(6), STAT3(3), STAT5A(3)	32676953	84	75	82	17	9	12	6	31	26	0	0.244	1.000	1.000
304	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(7), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(2), RAF1(4), SHC1(4), SOS1(9), SRF(1), STAT3(3)	23498579	62	58	62	15	5	7	10	26	14	0	0.395	1.000	1.000
305	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), AXIN1(5), CREBBP(10), CTNNB1(2), DVL1(1), EP300(16), FZD1(4), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(12), WNT1(2)	32696619	73	64	64	15	6	5	10	29	23	0	0.256	1.000	1.000
306	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5)	10376815	19	19	18	8	3	4	2	8	2	0	0.677	1.000	1.000
307	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), DDC(3), EPX(3), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), MYST3(4), MYST4(3), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(2), TPO(4)	32788441	67	59	66	13	9	8	14	22	14	0	0.0786	1.000	1.000
308	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(20), BMPR1B(2), CCND2(1), CDK4(6), CDKN1B(1), DAZL(3), ESR2(4), FSHR(2), GJA4(1), MLH1(3), NCOR1(7), NR5A1(1), NRIP1(7), PGR(5), PRLR(3), PTGER2(1), SMPD1(6), VDR(2), ZP2(6)	33163002	81	69	76	16	9	11	10	28	22	1	0.0914	1.000	1.000
309	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(5), IMPA1(1), IMPA2(3), PGM1(1)	11508127	12	11	12	8	4	0	0	5	3	0	0.962	1.000	1.000
310	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCR(2), CRKL(1), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAP3K1(8), MAPK3(3), MYC(2), PIK3R1(5), RAF1(4), SOS1(9), STAT1(6), STAT5A(3), STAT5B(3)	25443827	62	59	61	14	5	7	7	29	14	0	0.389	1.000	1.000
311	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(2), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLG(6), POLG2(5), POLH(5), POLI(3), POLK(5), POLL(2), POLM(4), POLQ(13), PRIM1(3), PRIM2(7), REV1(5), REV3L(17), RFC5(3)	41235141	98	83	92	18	5	8	7	46	32	0	0.294	1.000	1.000
312	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), STAT1(6), STAT3(3), STAT5A(3), STAT5B(3), THPO(1)	27670915	70	63	68	15	7	9	8	27	19	0	0.364	1.000	1.000
313	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(7), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(4), SHC1(4), SOS1(9), STAT5A(3), STAT5B(3), SYK(2)	23192421	54	52	53	13	7	7	9	18	13	0	0.323	1.000	1.000
314	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(4), ALDH18A1(1), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(6), GATM(2), NAGS(1), OAT(2), ODC1(2), OTC(1), PYCR1(1), SMS(2)	17506301	30	29	30	9	1	2	5	14	8	0	0.815	1.000	1.000
315	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BAX(1), BID(2), BIK(1), BIRC2(3), BIRC3(5), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), DIABLO(1)	13557694	23	23	23	8	1	4	5	8	5	0	0.707	1.000	1.000
316	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(3), DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), KLK2(1), MAPK3(3), NGFR(1), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(4), SOS1(9)	16551872	42	40	41	11	5	7	4	17	9	0	0.551	1.000	1.000
317	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(2), IKBKAP(2), IKBKB(3), IKBKG(1), LTA(1), MAP3K1(8), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1), TRAF3(1)	22639343	36	33	33	9	3	8	0	11	13	1	0.589	1.000	1.000
318	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IKBKB(3), IL4(1), JUN(2), MAP3K1(8), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TNFRSF9(1), TNFSF9(1), TRAF2(1)	19715506	41	37	38	10	2	5	1	18	14	1	0.757	1.000	1.000
319	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAPK14(1), MAPK3(3), NFKB1(2), PIK3R1(5), RB1(4), RELA(6), SP1(2)	17485075	40	38	37	10	3	7	1	16	10	3	0.707	1.000	1.000
320	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	25	ABAT(1), ABP1(5), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), AOC2(5), AOC3(2), CNDP1(5), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), MLYCD(3), SMS(2), UPB1(2)	26795291	65	61	64	17	4	9	16	22	12	2	0.239	1.000	1.000
321	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(5), ALAS2(5), AOC2(5), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(5), GATM(2), GLDC(4), GNMT(2), MAOA(2), MAOB(2), PHGDH(3), PIPOX(3), PISD(2), PSAT1(2), RDH11(4), RDH13(1), SARDH(5), SARS(3), SARS2(1), SHMT1(2), SHMT2(5), TARS(6), TARS2(7)	42587499	110	98	106	24	13	18	18	37	23	1	0.0623	1.000	1.000
322	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	42	ABAT(1), ACAA1(3), ACADM(1), ACADS(3), ACAT1(1), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(2), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(1), HSD17B4(2), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3)	41459035	79	76	77	15	6	9	21	30	12	1	0.0394	1.000	1.000
323	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(9), E2F1(1), MYC(2), PIK3R1(5), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), RAC1(1), RB1(4)	16343092	36	33	35	10	3	7	1	15	8	2	0.645	1.000	1.000
324	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(5), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), MAOA(2), MAOB(2), TAT(2), TH(4), TPO(4), TYR(5)	30366538	77	69	75	20	11	7	9	32	18	0	0.414	1.000	1.000
325	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(2), JAK1(7), JAK2(7), JAK3(4), PIAS3(3), PTPRU(5), SRC(4), STAT3(3)	15110643	37	33	37	10	2	5	5	15	10	0	0.628	1.000	1.000
326	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC2(4), ABCG2(2), BCHE(3), CES1(8), CES2(2), CYP3A5(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5)	19863911	41	36	39	11	2	3	9	14	13	0	0.616	1.000	1.000
327	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(8), ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), ATP7A(5), ATP7B(8), COX10(5), COX5A(1), COX6A2(1), COX7A1(2), COX7A2(1), COX8A(1), NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(2)	38390393	104	94	102	24	7	17	19	41	19	1	0.150	1.000	1.000
328	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	28	AMDHD2(4), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(3), GFPT2(1), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(4), HK1(5), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), PHPT1(1), RENBP(4)	28022287	52	50	52	11	8	6	8	19	10	1	0.117	1.000	1.000
329	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GCK(2), GFPT1(3), GNE(1), GNPDA1(1), HEXA(4), HK1(5), RENBP(4)	16947245	23	22	23	7	4	0	2	12	5	0	0.732	1.000	1.000
330	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), NT5M(2), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5), RRM1(3), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2), UPP1(2)	57025029	118	96	109	21	9	15	17	34	41	2	0.0522	1.000	1.000
331	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(5), DBH(2), DDC(3), GAD1(2), GAD2(2), HDC(1), MAOA(2), PAH(6), SLC18A3(2), TH(4), TPH1(2)	13885177	32	31	30	10	3	5	8	8	8	0	0.632	1.000	1.000
332	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA1(2), FUCA2(1), GALNS(6), GBA(3), GLB1(5), GNS(4), GUSB(7), HEXA(4), HGSNAT(3), HPSE(3), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), IDUA(6), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NAGLU(2), NEU1(1), SPAM1(8)	33873228	83	69	78	19	13	10	11	37	12	0	0.113	1.000	1.000
333	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(9), AR(5), ASAH1(3), BRAF(4), CAMP(1), DAG1(3), EGFR(10), GNA11(1), GNA15(1), GNAI1(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), MAPK10(2), MAPK14(1), PHKA2(5), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(4), SRC(4)	51066769	100	83	97	18	10	18	17	36	18	1	0.0227	1.000	1.000
334	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), DAG1(3), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), NFAT5(10), PDE6A(1), PDE6B(6), PDE6C(3), SLC6A13(7)	35983094	65	59	64	13	6	7	14	27	11	0	0.0993	1.000	1.000
335	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(9), ATF2(2), AXIN1(5), BMP10(1), BMP2(2), BMP4(1), BMP5(1), BMP7(5), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(2), DVL1(1), FZD1(4), GATA4(2), GSK3B(3), MAP3K7(3), MYL2(1), NKX2-5(3), NOG(2), NPPA(1), NPPB(1), RFC1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TGFBR3(3), WNT1(2)	35696562	79	67	77	17	12	7	5	33	21	1	0.180	1.000	1.000
336	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(20), CDC25A(1), CDC25B(1), CDC25C(3), CDK2(2), CDK4(6), CHEK1(1), MYT1(5), RB1(4), WEE1(2)	16965061	45	40	41	11	2	5	7	15	14	2	0.560	1.000	1.000
337	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	15	AHCY(5), AMD1(2), BHMT(7), CTH(2), DNMT3B(3), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), TAT(2)	15637296	33	32	33	10	3	6	7	12	5	0	0.597	1.000	1.000
338	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(1), ADCY1(2), CAP1(3), CCNB1(1), CDC25C(3), GNAI1(2), GNAS(5), GNB1(3), HRAS(1), MAPK3(3), MYT1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SRC(4)	18578089	47	44	47	13	6	8	3	23	7	0	0.469	1.000	1.000
339	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX5(4), CBR1(4), CYP4F2(4), CYP4F3(2), EPX(3), GGT1(4), LPO(1), LTA4H(4), MPO(6), PLA2G4A(2), PLA2G6(5), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4)	27591028	66	61	63	16	8	6	19	19	13	1	0.276	1.000	1.000
340	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(3), PAPSS2(4), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(4)	24467737	55	51	55	14	4	7	15	15	14	0	0.332	1.000	1.000
341	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(1), ACTR2(2), ARPC1B(2), NCK1(1), NCKAP1(3), NTRK1(8), PIR(1), PSMA7(1), RAC1(1), WASF1(1), WASF2(2), WASF3(3), WASL(7)	14575990	33	33	32	10	2	7	2	18	4	0	0.626	1.000	1.000
342	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), G6PD(2), H6PD(3), PFKL(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TALDO1(2), TKT(2), TKTL1(2), TKTL2(6)	22799459	47	47	47	13	6	8	6	16	11	0	0.459	1.000	1.000
343	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(10), EP300(16), IKBKB(3), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K14(2), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(6), TGFBR1(1), TGFBR2(2), TLR2(2), TNF(1)	29534966	64	54	58	14	5	9	7	20	21	2	0.345	1.000	1.000
344	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	40	AKT1(3), AKT2(5), AKT3(3), BRAF(4), DDIT4(1), EIF4B(5), EIF4EBP1(1), FIGF(2), HIF1A(4), INS(1), MAPK3(3), PGF(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRKAA1(1), RICTOR(7), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(3), TSC1(6), TSC2(13), ULK1(2), ULK2(3), ULK3(3), VEGFC(2)	47733502	105	97	102	22	12	18	15	36	20	4	0.0591	1.000	1.000
345	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(10), CMA1(1), CTSA(1), ENPEP(7), LNPEP(4), MAS1(1), MME(6), REN(1), THOP1(1)	21043556	49	43	44	14	2	6	13	18	10	0	0.672	1.000	1.000
346	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22(1), IL22RA1(3), IL22RA2(1), JAK1(7), JAK2(7), JAK3(4), SOCS3(1), STAT1(6), STAT3(3), STAT5A(3), STAT5B(3), TYK2(7)	18363912	50	48	48	14	4	0	10	22	14	0	0.808	1.000	1.000
347	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(2), CD3G(2), ETV5(3), IL12RB1(4), IL12RB2(2), IL18R1(1), JAK2(7), JUN(2), MAP2K6(1), MAPK14(1), STAT4(2), TYK2(7)	18708322	35	34	34	10	3	2	6	16	8	0	0.714	1.000	1.000
348	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(8), MYC(2), NFATC1(4), NFATC2(8), NFKB1(2), NFKBIA(2), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), SYT1(1), VIPR2(2)	27229521	65	60	59	17	8	6	1	23	26	1	0.694	1.000	1.000
349	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	43	AADAT(2), AASDHPPT(3), AASS(9), ACAT1(1), AKR1B10(3), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), BBOX1(2), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(9), HADH(1), HADHA(4), HSD17B4(2), NSD1(13), OGDH(8), OGDHL(2), PIPOX(3), PLOD1(3), PLOD2(5), RDH11(4), RDH13(1), SETD1A(8), SETD7(1), SETDB1(8), SHMT1(2), SHMT2(5), SPCS1(3), SUV39H2(5), TMLHE(1)	52685274	138	114	135	29	11	23	20	53	31	0	0.0504	1.000	1.000
350	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(2), CREBBP(10), EP300(16), IKBKB(3), IKBKG(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2)	22330282	50	45	44	13	3	8	7	12	19	1	0.574	1.000	1.000
351	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(4), CYP4F8(1), CYP51A1(2)	28654943	66	56	66	16	13	13	3	27	10	0	0.123	1.000	1.000
352	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(3), ALG5(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1B1(1), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), RPN1(3), RPN2(1), ST6GAL1(1)	19414258	37	35	37	10	2	9	1	13	12	0	0.446	1.000	1.000
353	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BAX(1), CASP8(1), MAP3K1(8), MAPK3(3), NFKB1(2), NSMAF(7), RAF1(4), RELA(6), RIPK1(1), SMPD1(6), TNFRSF1A(1), TRADD(2), TRAF2(1)	20354567	44	40	40	12	4	7	6	13	13	1	0.522	1.000	1.000
354	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	36	ACAA1(3), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1B10(3), AKR1C4(1), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), LIPA(1), RDH11(4), RDH13(1), SLC27A5(3), SOAT1(4), SOAT2(4), SRD5A1(1)	29753814	60	55	57	15	7	3	6	29	15	0	0.470	1.000	1.000
355	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(10), EP300(16), LPL(3), NCOA1(4), NCOA2(11), PPARG(2)	18385145	46	37	37	14	4	6	5	12	19	0	0.654	1.000	1.000
356	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	ARFIP2(1), CFL1(1), CHN1(2), MAP3K1(8), MYL2(1), MYLK(4), NCF2(1), PAK1(3), PDGFRA(8), PIK3R1(5), PLD1(3), PPP1R12B(2), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(9), VAV1(4), WASF1(1)	31689250	58	54	58	13	3	5	5	26	19	0	0.493	1.000	1.000
357	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(3), AP2M1(1), BIN1(6), CALM2(1), DNM1(4), EPN1(1), EPS15(3), PICALM(3), PPP3CA(3), PPP3CC(3), SYNJ1(6), SYNJ2(6), SYT1(1)	22148223	45	44	43	13	2	6	8	20	9	0	0.570	1.000	1.000
358	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(5), AKT3(3), CISH(2), GRB2(2), IARS(4), IL13RA1(2), IL4(1), IL4R(4), INPP5D(2), JAK1(7), JAK2(7), JAK3(4), PI3(1), PPP1R13B(4), RPS6KB1(2), SHC1(4), SOS1(9), SOS2(7), SRC(4), STAT6(5), TYK2(7)	34349153	89	74	88	21	7	13	16	33	20	0	0.215	1.000	1.000
359	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	22	ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), G6PD(2), H6PD(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TAL1(3), TALDO1(2), TKT(2)	18740246	39	38	39	12	5	5	6	13	10	0	0.655	1.000	1.000
360	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SOS1(9), SRF(1)	22005737	53	49	53	15	9	11	3	19	11	0	0.449	1.000	1.000
361	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(2), ATF2(2), CALM2(1), EGFR(10), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(8), MAPK3(3), MEF2A(3), MEF2D(1), PAK1(3), PRKCA(2), PTK2(3), PTK2B(3), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SRC(4), SYT1(1)	33840107	75	64	73	18	7	16	9	26	17	0	0.301	1.000	1.000
362	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(10), MAP3K1(8), MAPK14(1), NCOR2(7), RARA(4), THRA(2)	17113989	37	33	35	11	2	5	7	10	13	0	0.756	1.000	1.000
363	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(3), CAPN2(4), EGF(5), EGFR(10), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTK2(3), PXN(3), TLN1(14)	32783740	81	72	78	20	9	7	7	36	22	0	0.485	1.000	1.000
364	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(20), ATR(12), BRCA1(9), CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CDKN1A(3), CHEK1(1), CHEK2(2), EP300(16), MYT1(5), PRKDC(13), WEE1(2)	40678957	89	74	85	18	3	12	11	39	23	1	0.164	1.000	1.000
365	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), BST1(2), CD38(1), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(7), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(2), QPRT(1)	21512856	42	40	41	12	3	3	4	24	8	0	0.657	1.000	1.000
366	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	39	ABP1(5), ACY3(1), ALDH1B1(4), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), AMDHD1(2), AOC2(5), AOC3(2), ASPA(1), CNDP1(5), DDC(3), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2)	37226474	78	66	77	18	8	13	13	29	15	0	0.125	1.000	1.000
367	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(6), PIGB(2), PIGC(1), PIGF(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(6), PIGS(2), PIGT(6), PIGU(1), PIGV(1), PIGZ(3)	24309100	48	44	44	14	4	9	6	18	10	1	0.588	1.000	1.000
368	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(1), DAXX(6), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP2K6(1), MAP3K1(8), MAP3K5(5), MAP3K7(3), MAP3K9(6), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(3), MEF2D(1), MKNK1(2), MYC(2), PLA2G4A(2), RAC1(1), RIPK1(1), RPS6KA5(2), SHC1(4), STAT1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TRADD(2), TRAF2(1)	36779176	78	68	76	18	8	6	5	38	20	1	0.446	1.000	1.000
369	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(4), FLT1(10), FLT4(14), KDR(6), NOS3(4), PDE2A(3), PDE3A(4), PDE3B(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKG1(4), PRKG2(3), RYR2(17), SLC7A1(3), SYT1(1), TNNI1(1)	41123979	99	90	99	24	17	15	9	42	16	0	0.140	1.000	1.000
370	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CD28(1), CSK(4), CTLA4(3), DAG1(3), DTYMK(1), EPHB2(2), FBXW7(6), GRAP2(1), GRB2(2), ITK(2), ITPKA(2), ITPKB(2), LAT(1), LCK(1), LCP2(3), NCK1(1), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLCG1(4), PTPRC(8), RAF1(4), RASGRP1(3), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(9), SOS2(7), VAV1(4), ZAP70(1)	55484143	127	103	124	25	13	18	21	43	32	0	0.0515	1.000	1.000
371	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	20011083	43	38	40	13	5	5	3	10	19	1	0.831	1.000	1.000
372	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(3), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAPK14(1), MAPK3(3), NCF1(1), NCF2(1), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3C2G(5), PLCB1(4), PPP3CA(3), PPP3CC(3), RAC1(1), RAF1(4), RELA(6), SYT1(1)	38247438	91	78	85	22	12	10	6	32	30	1	0.500	1.000	1.000
373	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(9), ATM(20), ATR(12), CCNA1(8), CCNE1(3), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(1), TGFB2(3), TGFB3(1)	28773590	81	67	72	21	6	9	10	24	29	3	0.546	1.000	1.000
374	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(3), ATM(20), ATR(12), BAI1(6), BAX(1), BBC3(1), BID(2), CASP8(1), CASP9(2), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNG1(1), CCNG2(2), CD82(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CHEK1(1), CHEK2(2), FAS(2), GADD45B(1), GTSE1(4), IGFBP3(1), LRDD(1), PERP(1), PPM1D(2), RCHY1(3), RFWD2(3), RRM2(1), SERPINB5(5), SESN1(2), SFN(1), STEAP3(2), TNFRSF10B(1), TP53I3(6), TP73(4), TSC2(13), ZMAT3(1)	60299984	144	115	138	29	18	23	21	39	42	1	0.0256	1.000	1.000
375	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(2), GNB1(3), GRB2(2), HRAS(1), JAK2(7), MAP2K2(1), MAPK14(1), MAPK3(3), MAPT(4), MYLK(4), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(9), STAT1(6), STAT3(3), STAT5A(3), SYT1(1)	41878239	86	76	84	19	6	11	11	36	22	0	0.312	1.000	1.000
376	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	25	ABAT(1), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HMGCL(1), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1)	23849526	41	40	39	12	6	6	9	14	6	0	0.368	1.000	1.000
377	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(4), AKT1(3), CALM2(1), CALR(2), CAMK1(3), CAMK1G(3), CAMK4(3), CREBBP(10), CSNK1A1(2), ELSPBP1(2), F2(4), FGF2(1), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), MAPK14(1), MAPK3(3), MYH2(9), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKX2-5(3), NPPA(1), PIK3R1(5), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAF1(4), RPS6KB1(2), SYT1(1)	47536759	117	100	112	28	14	13	9	41	40	0	0.339	1.000	1.000
378	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	43	ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), CPT1A(2), CPT1C(4), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HSD17B4(2), PECI(1)	44750209	86	81	81	20	7	11	17	36	14	1	0.141	1.000	1.000
379	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	28	ABP1(5), ACY1(4), ADC(2), AGMAT(3), ALDH18A1(1), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), AMD1(2), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CPS1(6), GATM(2), MAOA(2), MAOB(2), NAGS(1), ODC1(2), OTC(1), SAT1(1), SAT2(2), SMS(2)	27322395	62	57	62	17	4	6	12	26	14	0	0.499	1.000	1.000
380	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(2), ALDH4A1(2), CAD(13), CPS1(6), EPRS(5), GAD1(2), GAD2(2), GCLC(4), GFPT1(3), GFPT2(1), GLS(7), GLS2(4), GLUD2(7), GLUL(2), GMPS(1), GNPNAT1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(1)	39509883	84	70	78	20	7	9	17	30	20	1	0.349	1.000	1.000
381	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(5), AKT3(3), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(4), DAG1(3), EPHB2(2), GRB2(2), ITPKA(2), ITPKB(2), LYN(1), MAP2K2(1), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(9), SOS2(7), SYK(2), VAV1(4)	49441181	101	87	100	21	12	14	16	39	20	0	0.0643	1.000	1.000
382	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(5), CLYBL(3), CS(2), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(3), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), OGDHL(2), PC(8), PCK1(5), PCK2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(5), SUCLG2(2)	29805307	84	71	81	24	5	15	8	33	22	1	0.562	1.000	1.000
383	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(2), AKT1(3), AKT2(5), AKT3(3), DAG1(3), IKBKG(1), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(5), PITX2(2), PLD1(3), PLD2(7), PLD3(3)	44709441	83	69	81	18	11	12	14	31	15	0	0.0695	1.000	1.000
384	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	29	A1BG(1), AKT1(3), AKT2(5), AKT3(3), BAD(1), BTK(1), DAPP1(2), GRB2(2), GSK3A(3), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PPP1R13B(4), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SOS1(9), SOS2(7), TEC(6), YWHAE(1)	30929354	69	63	67	18	4	13	12	24	16	0	0.362	1.000	1.000
385	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	29	ABAT(1), ACACA(8), ACADL(3), ACADM(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(5), SUCLG2(2)	31321844	62	59	60	16	4	7	16	22	11	2	0.274	1.000	1.000
386	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(2), ARRB2(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA4(2), CNGA3(5), CNGA4(4), CNGB1(6), GUCA1B(2), PDC(1), PDE1C(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKG1(4), PRKG2(3), PRKX(2)	30876627	60	57	57	16	8	7	5	28	12	0	0.511	1.000	1.000
387	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(6), DIAPH1(7), FYN(2), GSN(5), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PIK3R1(5), PTK2(3), PXN(3), RAF1(4), ROCK1(5), SHC1(4), SRC(4), TLN1(14)	35169158	86	76	85	21	7	11	9	32	27	0	0.492	1.000	1.000
388	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(10), DAXX(6), HRAS(1), PAX3(2), PML(6), RARA(4), RB1(4), SIRT1(6), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	17648356	44	41	44	14	5	7	6	12	12	2	0.705	1.000	1.000
389	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH3B1(4), ALDH3B2(3), AOC2(5), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), MYST3(4), MYST4(3), PNPLA3(3), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(2), TH(4), TPO(4), TYR(5), TYRP1(4)	57842860	120	100	118	27	13	12	18	48	29	0	0.163	1.000	1.000
390	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(10), APOA1(1), CETP(1), DGAT1(2), LCAT(5), LDLR(3), LIPC(1), LPL(3), LRP1(15), SCARB1(4), SOAT1(4)	26955573	49	45	47	13	4	10	5	19	11	0	0.355	1.000	1.000
391	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), REN(1)	25559695	43	40	43	14	4	12	5	16	6	0	0.433	1.000	1.000
392	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), AKT1(3), AKT2(5), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(6), BIRC2(3), BIRC3(5), BRAF(4), CAPN2(4), CAV2(2), CAV3(1), CCND2(1), CDC42(1), CHAD(3), COL11A1(11), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), CRKL(1), CTNNB1(2), DIAPH1(7), DOCK1(3), EGF(5), EGFR(10), ELK1(1), ERBB2(8), FARP2(3), FIGF(2), FLNA(6), FLNB(7), FLNC(10), FLT1(10), FN1(8), FYN(2), GRB2(2), GRLF1(6), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(3), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), JUN(2), KDR(6), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), MAPK10(2), MAPK3(3), MAPK9(2), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(8), PDGFRB(3), PGF(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PRKCA(2), PRKCG(6), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF1(6), RELN(7), ROCK1(5), ROCK2(4), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SPP1(3), SRC(4), THBS2(3), THBS3(7), THBS4(4), TLN1(14), TLN2(12), TNC(13), TNN(3), TNR(9), TNXB(11), VAV1(4), VAV2(4), VAV3(1), VCL(2), VEGFC(2), VTN(1), VWF(15), ZYX(1)	359232733	774	409	757	225	84	103	105	290	187	5	0.412	1.000	1.000
393	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(4), ACVR1C(3), AKT1(3), AKT2(5), AKT3(3), ARRB1(3), ARRB2(1), ATF2(2), ATF4(2), BDNF(2), BRAF(4), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(11), CACNA1H(8), CACNA1I(7), CACNA1S(14), CACNA2D1(6), CACNA2D2(1), CACNA2D4(5), CACNB1(4), CACNB2(1), CACNB4(1), CACNG2(2), CACNG3(2), CACNG4(1), CACNG5(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), CRKL(1), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(2), DUSP6(2), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(10), ELK1(1), ELK4(3), FAS(2), FASLG(3), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(10), FGFR4(3), FLNA(6), FLNB(7), FLNC(10), FOS(1), GADD45B(1), GNA12(1), GNG12(2), GRB2(2), HRAS(1), IKBKB(3), IKBKG(1), IL1B(1), IL1R1(3), IL1R2(8), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(4), MAP2K5(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP4K1(5), MAP4K2(1), MAP4K3(6), MAP4K4(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAPT(4), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(2), NF1(11), NFATC2(8), NFATC4(3), NFKB1(2), NFKB2(3), NLK(1), NR4A1(1), NRAS(2), NTRK1(8), NTRK2(2), PAK1(3), PAK2(4), PDGFRA(8), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PPM1A(3), PPM1B(3), PPP3CA(3), PPP3CC(3), PPP3R2(2), PPP5C(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(5), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF2(8), RASA1(7), RASA2(2), RASGRF1(8), RASGRF2(4), RASGRP1(3), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KA6(1), SOS1(9), SOS2(7), SRF(1), STK3(1), TAOK2(4), TAOK3(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF1A(1), TRAF2(1), TRAF6(2), ZAK(4)	284905674	624	371	608	176	79	80	83	237	142	3	0.322	1.000	1.000
394	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY7(1), ADCY8(13), ADCY9(7), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(8), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(11), CACNA1H(8), CACNA1I(7), CACNA1S(14), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(4), CD38(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(8), ERBB3(8), ERBB4(11), F2R(2), GNA11(1), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(8), GRIN2D(2), GRM1(5), GRM5(9), GRPR(2), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), LTB4R2(1), MYLK(4), MYLK2(1), NOS1(10), NOS3(4), NTSR1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), PDE1A(1), PDE1B(5), PDE1C(2), PDGFRA(8), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(6), PHKG1(4), PHKG2(1), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), PTAFR(2), PTGFR(5), PTK2B(3), RYR1(23), RYR2(17), RYR3(17), SLC25A4(2), SLC25A5(4), SLC25A6(2), SLC8A1(3), SLC8A2(3), SLC8A3(5), SPHK1(2), SPHK2(1), TACR1(2), TACR2(2), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(3), VDAC2(1), VDAC3(2)	269778931	594	371	577	177	106	79	64	226	119	0	0.247	1.000	1.000
395	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), APC(9), APC2(5), ARAF(1), ARHGEF1(2), ARHGEF12(5), ARHGEF4(2), ARHGEF6(4), ARHGEF7(5), ARPC1B(2), ARPC5L(1), BAIAP2(2), BCAR1(6), BDKRB1(1), BDKRB2(1), BRAF(4), C3orf10(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CRKL(1), CSK(4), CYFIP1(7), CYFIP2(7), DIAPH1(7), DIAPH2(2), DIAPH3(7), DOCK1(3), EGF(5), EGFR(10), EZR(2), F2(4), F2R(2), FGD1(3), FGD3(1), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(10), FGFR4(3), FN1(8), GIT1(4), GNA12(1), GNA13(4), GNG12(2), GRLF1(6), GSN(5), HRAS(1), INS(1), IQGAP1(7), IQGAP2(7), IQGAP3(7), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), KRAS(3), LIMK2(4), MAP2K2(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(3), MYH14(8), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(3), NCKAP1L(5), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDGFRA(8), PDGFRB(3), PFN2(1), PFN3(1), PFN4(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R12B(2), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), RDX(2), ROCK1(5), ROCK2(4), SCIN(4), SLC9A1(3), SOS1(9), SOS2(7), SSH1(2), SSH2(12), SSH3(2), TIAM1(9), TIAM2(1), VAV1(4), VAV2(4), VAV3(1), VCL(2), WAS(1), WASF1(1), WASF2(2), WASL(7)	273349995	599	359	581	154	62	77	84	234	138	4	0.122	1.000	1.000
396	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(7), ACTG1(3), CHAD(3), COL11A1(11), COL11A2(5), COL17A1(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), DES(1), DSC2(5), DSC3(3), DSG1(4), DSG2(3), DSG3(3), DSG4(5), FN1(8), GJA10(3), GJA3(2), GJA4(1), GJA5(5), GJA8(2), GJA9(1), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GJC1(3), GJC2(1), GJD2(1), IBSP(1), ITGA6(6), ITGB4(6), KRT1(3), KRT10(2), KRT12(2), KRT13(6), KRT15(3), KRT16(1), KRT17(3), KRT18(1), KRT19(2), KRT2(6), KRT20(1), KRT23(3), KRT24(1), KRT25(1), KRT27(4), KRT28(2), KRT3(2), KRT31(1), KRT32(1), KRT33A(1), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(5), KRT40(2), KRT5(3), KRT6A(3), KRT6B(3), KRT6C(1), KRT7(1), KRT71(3), KRT72(2), KRT73(2), KRT74(2), KRT75(4), KRT76(4), KRT77(4), KRT78(3), KRT79(4), KRT81(1), KRT82(2), KRT83(2), KRT84(4), KRT85(6), KRT86(2), KRT9(2), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), LMNB1(3), LMNB2(1), NES(8), PRPH(3), RELN(7), SPP1(3), THBS2(3), THBS3(7), THBS4(4), TNC(13), TNN(3), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15)	241280275	539	328	528	188	64	74	60	199	140	2	0.945	1.000	1.000
397	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), C5AR1(3), CALCR(3), CALCRL(2), CCKAR(4), CCKBR(4), CGA(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(3), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2(4), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(5), GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(3), GABRB2(3), GABRB3(2), GABRD(2), GABRE(5), GABRG1(3), GABRG2(6), GABRG3(3), GABRQ(8), GABRR1(2), GABRR2(1), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(3), GLRA1(3), GLRA2(2), GLRB(2), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(8), GRIA2(4), GRIA3(2), GRIA4(4), GRID1(4), GRID2(9), GRIK1(4), GRIK2(5), GRIK3(6), GRIK5(5), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRIN3A(2), GRIN3B(5), GRM1(5), GRM2(5), GRM3(5), GRM4(6), GRM5(9), GRM6(2), GRM7(5), GRM8(4), GRPR(2), HCRTR1(2), HCRTR2(5), HRH2(1), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), LEP(1), LEPR(5), LTB4R2(1), MAS1(1), MC2R(3), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMBR(1), NMUR2(6), NPBWR1(2), NPBWR2(1), NPFFR2(3), NPY1R(2), NPY2R(2), NR3C1(4), NTSR1(3), OPRD1(3), OPRK1(2), OPRM1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(6), PRLR(3), PRSS1(6), PRSS3(12), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), TAAR2(2), TAAR9(2), TACR1(2), TACR2(2), TACR3(2), TBXA2R(4), THRA(2), TRHR(2), TRPV1(1), TSHR(2), TSPO(1), UTS2R(2), VIPR1(1), VIPR2(2)	214927195	490	311	478	160	79	69	70	184	88	0	0.484	1.000	1.000
398	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(10), CD36(1), CD44(3), CHAD(3), COL11A1(11), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(9), COL5A2(6), COL5A3(12), COL6A1(4), COL6A2(7), COL6A3(21), COL6A6(17), DAG1(3), FN1(8), FNDC1(3), FNDC3A(4), FNDC5(1), GP6(1), GP9(1), HMMR(1), HSPG2(14), IBSP(1), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), LAMA1(12), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(6), LAMC1(5), LAMC2(6), LAMC3(8), RELN(7), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SPP1(3), SV2A(1), SV2B(3), SV2C(3), THBS2(3), THBS3(7), THBS4(4), TNC(13), TNN(3), TNR(9), TNXB(11), VTN(1), VWF(15)	218343637	460	302	450	141	50	61	56	165	125	3	0.654	1.000	1.000
399	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ADRA1A(4), ADRB2(2), ANXA6(3), ARRB1(3), ARRB2(1), ATP1A4(4), ATP1B1(5), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), CACNA1A(14), CACNA1B(5), CACNA1C(18), CACNA1D(9), CACNA1E(3), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), GJA4(1), GJA5(5), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GNA11(1), GNAI2(2), GNAI3(2), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), ITPR1(7), ITPR2(13), ITPR3(5), KCNB1(2), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PKIB(1), PLCB3(3), PRKACA(2), PRKACB(5), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS6(3), RGS7(2), RGS9(5), RYR1(23), RYR2(17), RYR3(17), SFN(1), SLC8A1(3), SLC8A3(5), USP5(4)	189765843	419	284	408	128	75	53	42	150	99	0	0.392	1.000	1.000
400	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), AKT1(3), AKT2(5), AKT3(3), AMOTL1(4), ASH1L(8), CASK(2), CDC42(1), CDK4(6), CGN(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CSDA(4), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), EPB41(2), EPB41L1(4), EPB41L2(2), EPB41L3(7), EXOC4(3), F11R(1), GNAI1(2), GNAI2(2), GNAI3(2), HCLS1(1), HRAS(1), IGSF5(5), INADL(10), JAM3(1), KRAS(3), LLGL1(5), LLGL2(3), MAGI1(5), MAGI2(6), MAGI3(4), MLLT4(11), MPDZ(4), MPP5(1), MRAS(1), MYH1(5), MYH10(3), MYH11(10), MYH13(7), MYH14(8), MYH15(5), MYH2(9), MYH3(7), MYH4(15), MYH6(7), MYH7(13), MYH7B(7), MYH8(6), MYH9(5), MYL2(1), MYL7(2), MYL9(1), NRAS(2), OCLN(3), PARD3(6), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), RAB13(1), RAB3B(1), SPTAN1(12), SRC(4), SYMPK(1), TJAP1(4), TJP1(6), TJP2(4), TJP3(1), YES1(2), ZAK(4)	191520700	408	271	392	130	43	52	51	138	122	2	0.905	1.000	1.000
401	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(4), ACVR2A(4), ACVR2B(1), BMP2(2), BMP7(5), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL2(1), CCL27(2), CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CD27(3), CD40(1), CLCF1(1), CNTF(1), CSF1R(8), CSF2RA(5), CSF2RB(5), CSF3R(4), CX3CL1(2), CX3CR1(1), CXCL1(1), CXCL11(1), CXCL13(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(2), EDA2R(1), EGF(5), EGFR(10), EPOR(3), FAS(2), FASLG(3), FLT1(10), FLT3(6), FLT4(14), GDF5(5), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(3), IL17RA(1), IL17RB(4), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(8), IL1RAP(4), IL20RA(1), IL21(1), IL21R(5), IL22(1), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), INHBA(2), INHBB(2), INHBC(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEP(1), LEPR(5), LIFR(5), LTA(1), LTB(1), LTBR(2), NGFR(1), OSM(2), OSMR(1), PDGFC(1), PDGFRA(8), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF4(1), TNFRSF9(1), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(2), TNFSF9(1), TPO(4), VEGFC(2), XCL1(3), XCR1(1)	171207094	360	267	353	73	36	52	47	150	75	0	0.00188	1.000	1.000
402	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(9), ABLIM1(5), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(4), EFNA1(2), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(4), EPHA2(1), EPHA3(5), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(2), EPHA8(7), EPHB1(4), EPHB2(2), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(2), GNAI2(2), GNAI3(2), GSK3B(3), HRAS(1), ITGB1(7), KRAS(3), L1CAM(5), LIMK2(4), LRRC4C(2), MAPK3(3), NCK1(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NGEF(1), NRAS(2), NRP1(2), NTN4(2), NTNG1(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLXNA1(4), PLXNA2(10), PLXNA3(5), PLXNB1(10), PLXNB2(6), PLXNB3(4), PLXNC1(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PTK2(3), RAC1(1), RAC2(1), RAC3(1), RASA1(7), RGS3(8), RND1(3), ROBO1(5), ROBO2(9), ROBO3(4), ROCK1(5), ROCK2(4), SEMA3A(4), SEMA3B(1), SEMA3C(2), SEMA3D(4), SEMA3E(3), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(7), SEMA4G(4), SEMA5A(6), SEMA5B(2), SEMA6A(3), SEMA6B(2), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(9), SLIT3(8), SRGAP1(10), SRGAP2(3), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(3), UNC5D(2)	188813216	404	267	383	115	45	50	48	153	106	2	0.538	1.000	1.000
403	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ARRB1(3), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CREB3(2), CRHR1(2), DGKZ(5), ETS2(1), FOS(1), GABPA(2), GABPB2(1), GBA2(5), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(3), IGFBP3(1), IGFBP4(2), IGFBP6(3), IL1B(1), ITPR1(7), ITPR2(13), ITPR3(5), JUN(2), MIB1(1), MYL2(1), MYLK2(1), NFKB1(2), NOS1(10), NOS3(4), OXTR(1), PDE4B(2), PDE4D(2), PKIA(1), PKIB(1), PLCB3(3), PLCD1(3), PLCG1(4), PLCG2(4), PRKACA(2), PRKACB(5), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(8), RGS6(3), RGS7(2), RGS9(5), RLN1(1), RYR1(23), RYR2(17), RYR3(17), SFN(1), SLC8A1(3), SP1(2), TNXB(11), USP5(4)	172236472	363	261	356	99	56	52	38	132	85	0	0.240	1.000	1.000
404	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(4), CADM1(3), CADM3(3), CD2(2), CD22(4), CD276(2), CD28(1), CD34(2), CD40(1), CD58(1), CD6(3), CD80(1), CD86(3), CD8A(1), CD99(2), CDH1(2), CDH15(1), CDH2(7), CDH3(3), CDH4(6), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CNTN1(7), CNTN2(3), CNTNAP1(9), CNTNAP2(5), CTLA4(3), ESAM(3), F11R(1), GLG1(5), HLA-A(6), HLA-B(10), HLA-C(10), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), HLA-E(2), HLA-F(2), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(6), ITGA8(3), ITGA9(3), ITGAL(7), ITGAM(9), ITGAV(1), ITGB1(7), ITGB2(2), ITGB7(4), ITGB8(1), JAM3(1), L1CAM(5), MADCAM1(3), MAG(1), MPZL1(2), NCAM1(3), NCAM2(6), NEGR1(2), NEO1(5), NFASC(8), NRCAM(5), NRXN1(10), NRXN2(6), NRXN3(5), OCLN(3), PDCD1(1), PTPRC(8), PTPRF(8), PTPRM(8), PVRL1(1), PVRL2(6), PVRL3(4), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SELE(6), SELL(2), SELP(2), SELPLG(3), SIGLEC1(5), SPN(1), VCAM1(6), VCAN(16)	143069901	368	257	362	130	36	46	55	155	76	0	0.932	1.000	1.000
405	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(8), ACACB(5), AKT1(3), AKT2(5), AKT3(3), ARAF(1), BAD(1), BRAF(4), CALM2(1), CBL(3), CBLB(4), CBLC(2), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(6), FASN(9), FBP1(1), FLOT1(1), FLOT2(1), FOXO1(5), G6PC(3), GCK(2), GRB2(2), GSK3B(3), GYS1(3), GYS2(3), HRAS(1), IKBKB(3), INPP5D(2), INS(1), INSR(6), IRS1(5), IRS4(1), KRAS(3), LIPE(6), MAP2K2(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(1), NRAS(2), PCK1(5), PCK2(2), PDE3A(4), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(6), PHKG1(4), PHKG2(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PKLR(1), PKM2(1), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAB1(1), PRKACA(2), PRKACB(5), PRKACG(3), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCI(5), PRKCZ(2), PRKX(2), PTPN1(2), PTPRF(8), PYGB(3), PYGL(2), PYGM(4), RAF1(4), RAPGEF1(6), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SLC2A4(3), SOCS3(1), SOCS4(1), SORBS1(3), SOS1(9), SOS2(7), SREBF1(4), TRIP10(2), TSC1(6), TSC2(13)	154147798	346	255	337	77	35	53	49	135	71	3	0.00867	1.000	1.000
406	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(9), APC2(5), AXIN1(5), AXIN2(1), BTRC(2), CACYBP(4), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(6), CREBBP(10), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(3), CTNNB1(2), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(1), DKK2(1), DVL1(1), DVL2(1), EP300(16), FBXW11(2), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(8), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKD1(4), NKD2(4), NLK(1), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRICKLE1(4), PRICKLE2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAC1(1), RAC2(1), RAC3(1), RBX1(1), ROCK1(5), ROCK2(4), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(2), SMAD2(2), SMAD3(2), SMAD4(3), TBL1X(3), TBL1XR1(5), TCF7L1(2), TCF7L2(1), VANGL1(5), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1)	157230717	342	249	329	86	35	35	48	125	98	1	0.182	1.000	1.000
407	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(3), AKT2(5), AKT3(3), CBL(3), CBLB(4), CBLC(2), CCND2(1), CISH(2), CLCF1(1), CNTF(1), CREBBP(10), CSF2RA(5), CSF2RB(5), CSF3R(4), EP300(16), EPOR(3), GH2(1), GHR(1), GRB2(2), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(3), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22(1), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), IRF9(2), JAK1(7), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIFR(5), MYC(2), OSM(2), OSMR(1), PIAS1(5), PIAS2(3), PIAS3(3), PIAS4(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRLR(3), PTPN11(2), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(9), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(1), SPRY2(3), STAM(6), STAT1(6), STAT2(6), STAT3(3), STAT4(2), STAT5A(3), STAT5B(3), STAT6(5), TPO(4), TYK2(7)	141745004	326	232	317	79	26	45	56	126	73	0	0.103	1.000	1.000
408	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ADK(1), ADSL(3), ADSSL1(2), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), ENTPD5(3), ENTPD6(2), GART(4), GDA(3), GMPR(2), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(2), NME7(2), NPR1(4), NPR2(5), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), NUDT5(4), NUDT9(1), PAPSS1(3), PAPSS2(4), PDE10A(1), PDE11A(7), PDE1A(1), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(5), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PFAS(3), PKLR(1), PKM2(1), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PPAT(3), PRIM1(3), PRIM2(7), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(3), RRM1(3), RRM2(1), XDH(7)	162727812	320	228	312	76	32	46	36	128	78	0	0.100	1.000	1.000
409	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(3), BCAR1(6), CAPN1(3), CAPN10(2), CAPN11(5), CAPN2(4), CAPN3(8), CAPN5(3), CAPN6(2), CAPN7(4), CAPN9(3), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(3), FYN(2), GIT2(4), GRB2(2), ILK(4), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(6), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(1), MAPK7(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PIK3R2(3), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAPGEF1(6), RHO(1), ROCK1(5), ROCK2(4), SDCCAG8(1), SEPP1(4), SHC1(4), SHC3(2), SORBS1(3), SOS1(9), SRC(4), TLN1(14), TNS1(9), VAV2(4), VAV3(1), VCL(2), ZYX(1)	134851201	310	228	299	93	26	49	43	122	68	2	0.583	1.000	1.000
410	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), DRD1(1), DRD2(1), EGF(5), EGFR(10), GJD2(1), GNA11(1), GNAI1(2), GNAI2(2), GNAI3(2), GNAS(5), GRB2(2), GRM1(5), GRM5(9), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(1), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), MAP2K2(1), MAP2K5(4), MAP3K2(2), MAPK3(3), MAPK7(4), NPR1(4), NPR2(5), NRAS(2), PDGFC(1), PDGFD(4), PDGFRA(8), PDGFRB(3), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(9), SOS2(7), SRC(4), TJP1(6), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4)	131344298	295	213	288	92	36	46	30	120	63	0	0.695	1.000	1.000
411	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ATF4(2), CACNA1C(18), CACNA1D(9), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(1), GNA11(1), GNAS(5), GRB2(2), HRAS(1), ITPR1(7), ITPR2(13), ITPR3(5), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK9(2), MMP14(1), MMP2(7), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLD1(3), PLD2(7), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCD(5), PRKX(2), PTK2B(3), RAF1(4), SOS1(9), SOS2(7), SRC(4)	128842288	290	211	281	89	41	47	31	115	56	0	0.444	1.000	1.000
412	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(8), ASH2L(3), CTCFL(5), DOT1L(9), EED(1), EHMT1(4), EHMT2(9), EZH1(3), EZH2(4), FBXO11(6), HCFC1(8), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(11), MEN1(1), MLL(6), MLL2(26), MLL3(38), MLL4(8), MLL5(9), NSD1(13), OGT(5), PAXIP1(4), PPP1CA(1), PPP1CC(2), PRDM2(4), PRDM6(1), PRDM7(5), PRDM9(8), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), RBBP5(5), SATB1(4), SETD1A(8), SETD1B(2), SETD7(1), SETDB1(8), SETMAR(2), SMYD3(2), SUV39H2(5), SUV420H1(3), SUZ12(6), WHSC1(6), WHSC1L1(6)	116505608	279	208	277	66	24	37	37	97	82	2	0.111	1.000	1.000
413	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(7), ACTG1(3), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), ACVR1B(4), ACVR1C(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(10), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), CTNND1(5), EGFR(10), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(3), INSR(6), IQGAP1(7), LEF1(3), LMO7(12), MAP3K7(3), MAPK3(3), MLLT4(11), NLK(1), PARD3(6), PTPN1(2), PTPN6(3), PTPRB(5), PTPRF(8), PTPRJ(12), PTPRM(8), PVRL1(1), PVRL2(6), PVRL3(4), RAC1(1), RAC2(1), RAC3(1), SMAD2(2), SMAD3(2), SMAD4(3), SNAI1(1), SNAI2(3), SORBS1(3), SRC(4), SSX2IP(5), TCF7L1(2), TCF7L2(1), TGFBR1(1), TGFBR2(2), TJP1(6), VCL(2), WAS(1), WASF1(1), WASF2(2), WASF3(3), WASL(7), YES1(2)	116981527	279	204	262	75	31	33	45	98	70	2	0.340	1.000	1.000
414	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(1), BID(2), BRAF(4), CD48(1), FAS(2), FASLG(3), FCER1G(1), FCGR3B(2), FYN(2), GRB2(2), HCST(1), HLA-A(6), HLA-B(10), HLA-C(10), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IFNGR1(3), IFNGR2(2), ITGAL(7), ITGB2(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(5), KLRC3(1), KRAS(3), LAT(1), LCK(1), LCP2(3), MAP2K2(1), MAPK3(3), MICA(1), MICB(4), NCR1(1), NCR2(1), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NRAS(2), PAK1(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRF1(1), PRKCA(2), PRKCG(6), PTK2B(3), PTPN11(2), PTPN6(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SH2D1B(1), SH3BP2(6), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), ULBP1(2), ULBP2(1), ULBP3(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1)	108727093	277	201	270	73	24	42	38	108	64	1	0.348	1.000	1.000
415	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(2), ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADK(1), ADSL(3), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), ATP1B1(5), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G2(1), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), GART(4), GDA(3), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HPRT1(1), IMPDH1(1), IMPDH2(2), NPR1(4), NPR2(5), NT5M(2), PAPSS1(3), PAPSS2(4), PDE1A(1), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE5A(5), PDE6B(6), PDE6C(3), PDE7B(1), PDE8A(2), PFAS(3), PKLR(1), PKM2(1), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(13), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(3), RRM2(1)	126537800	269	201	264	56	32	36	31	103	67	0	0.0247	1.000	1.000
416	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(4), CACNA1A(14), CRHR1(2), GNA11(1), GNA12(1), GNA13(4), GNAI1(2), GNAI2(2), GNAI3(2), GNAO1(1), GNAS(5), GNAZ(4), GRIA1(8), GRIA2(4), GRIA3(2), GRID2(9), GRM1(5), GRM5(9), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(5), HRAS(1), IGF1R(3), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), LYN(1), MAP2K2(1), MAPK3(3), NOS1(10), NOS3(4), NPR1(4), NPR2(5), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), RAF1(4), RYR1(23)	110431542	254	196	250	71	44	27	30	99	53	1	0.338	1.000	1.000
417	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(3), ACTN3(1), ACTN4(3), DES(1), DMD(13), FAM48A(1), MYBPC1(5), MYBPC2(4), MYBPC3(3), MYH3(7), MYH6(7), MYH7(13), MYH8(6), MYL1(4), MYL2(1), MYL9(1), MYOM1(6), NEB(23), TCAP(1), TMOD1(6), TNNI1(1), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(124), VIM(2)	140734031	245	194	239	75	23	42	28	99	49	4	0.588	1.000	1.000
418	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCBP2(2), CCKAR(4), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CCRL1(2), CCRL2(1), CHML(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(3), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(3), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR77(1), GPR83(2), GPR85(3), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(5), HRH2(1), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMBR(1), NMUR2(6), NPY1R(2), NPY2R(2), NTSR1(3), OPN1SW(2), OPRD1(3), OPRK1(2), OPRM1(3), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR1Q1(1), OR7A5(2), OR7C1(2), OR8B8(2), OXTR(1), P2RY1(3), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY6(2), PTAFR(2), PTGDR(2), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RHO(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(4), TRHR(2)	115278121	247	192	245	86	43	30	32	102	40	0	0.579	1.000	1.000
419	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(9), ANAPC1(4), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), ATM(20), ATR(12), BUB1(2), BUB1B(1), BUB3(1), CCNA1(8), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNH(1), CDC14A(5), CDC14B(1), CDC16(4), CDC20(3), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(10), CUL1(5), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(13), FZR1(4), GADD45B(1), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), ORC1L(1), ORC2L(1), PCNA(4), PKMYT1(1), PLK1(1), PRKDC(13), PTTG2(1), RB1(4), RBL2(5), RBX1(1), SFN(1), SKP2(1), SMAD2(2), SMAD3(2), SMAD4(3), SMC1A(4), SMC1B(4), TGFB2(3), TGFB3(1), WEE1(2), YWHAE(1)	133986462	276	191	261	72	26	33	41	93	79	4	0.236	1.000	1.000
420	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(3), ARHGAP5(6), BCAR1(6), CD99(2), CDC42(1), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(2), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CLDN9(1), CTNNA1(7), CTNNA2(8), CTNNA3(3), CTNNB1(2), CTNND1(5), CXCR4(1), ESAM(3), EZR(2), F11R(1), GNAI1(2), GNAI2(2), GNAI3(2), GRLF1(6), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), ITK(2), JAM3(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(11), MMP2(7), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), NCF1(1), NCF2(1), NOX1(7), NOX3(6), OCLN(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(3), RAPGEF4(2), ROCK1(5), ROCK2(4), SIPA1(4), TXK(1), VAV1(4), VAV2(4), VAV3(1), VCAM1(6), VCL(2)	121625543	258	190	250	75	35	32	30	95	65	1	0.589	1.000	1.000
421	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(7), AMY2A(1), AMY2B(2), ASCC3(6), ATP13A2(8), DDX18(4), DDX23(3), DDX4(5), DDX41(3), DDX47(3), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(4), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), G6PC(3), GAA(3), GANC(3), GBA(3), GBA3(3), GBE1(2), GCK(2), GUSB(7), GYS1(3), GYS2(3), HK1(5), IFIH1(4), MGAM(9), MOV10L1(6), NUDT5(4), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(4), UGDH(1), UGP2(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UXS1(1)	122997694	249	188	243	81	18	31	47	90	62	1	0.811	1.000	1.000
422	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(1), ACVR1B(4), ACVRL1(1), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(5), BUB1(2), CDKL1(1), CDKL2(4), CDS2(2), CLK1(5), CLK2(2), CLK4(5), COL4A3BP(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(2), ITPKB(2), MAP3K10(4), MOS(1), NEK1(3), NEK3(3), OCRL(3), PAK4(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3CB(5), PIK3CG(4), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCG1(4), PLCG2(4), PLK3(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(2), PRKD1(4), PRKG1(4), RAF1(4), RPS6KA3(3), RPS6KA4(2), RPS6KB1(2), STK11(3), TGFBR1(1), VRK1(1)	110028100	240	184	237	56	23	36	22	88	71	0	0.106	1.000	1.000
423	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(9), ABL2(6), AKT1(3), AKT2(5), AKT3(3), ARAF(1), AREG(1), BAD(1), BRAF(4), BTC(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), CDKN1B(1), CRKL(1), EGF(5), EGFR(10), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(8), ERBB4(11), GAB1(2), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(3), MAP2K2(1), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(2), NCK1(1), NCK2(2), NRAS(2), NRG1(6), NRG2(4), NRG3(5), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), RAF1(4), RPS6KB1(2), RPS6KB2(2), SHC1(4), SHC2(4), SHC3(2), SHC4(1), SOS1(9), SOS2(7), SRC(4), STAT5A(3), STAT5B(3), TGFA(1)	100063974	249	183	240	52	25	36	43	96	47	2	0.0187	1.000	1.000
424	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(7), AKAP3(3), AKAP4(3), AKAP5(1), AKAP6(6), AKAP7(1), AKAP8(2), AKAP9(22), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA11(1), GNA12(1), GNA13(4), GNA15(1), GNAI2(2), GNAI3(2), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(2), GNG12(2), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(7), KCNJ3(4), KRAS(3), NRAS(2), PALM2(1), PDE1A(1), PDE1B(5), PDE1C(2), PDE4A(3), PDE4B(2), PDE4C(7), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PLCB3(3), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PRKD1(4), PRKD3(4), SLC9A1(3), USP5(4)	117000085	254	182	247	71	26	37	16	103	71	1	0.501	1.000	1.000
425	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(10), ABCA10(6), ABCA12(16), ABCA13(23), ABCA2(4), ABCA3(4), ABCA4(11), ABCA5(10), ABCA6(5), ABCA7(11), ABCA8(6), ABCA9(3), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(8), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(2), ABCC10(7), ABCC11(7), ABCC12(4), ABCC2(4), ABCC3(11), ABCC4(7), ABCC5(7), ABCC6(7), ABCC8(5), ABCC9(5), ABCD1(3), ABCD2(2), ABCD3(2), ABCD4(4), ABCG1(1), ABCG2(2), ABCG4(7), ABCG5(3), ABCG8(5), CFTR(9), TAP1(1), TAP2(1)	115209665	242	178	234	75	15	41	35	101	49	1	0.498	1.000	1.000
426	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM2(1), CDS2(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(3), INPPL1(4), ITPK1(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), OCRL(3), PI4KA(10), PI4KB(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3C3(4), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(6), PTPMT1(2), SYNJ1(6), SYNJ2(6)	122610042	237	178	229	72	26	38	24	89	59	1	0.601	1.000	1.000
427	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(5), AKT3(3), BCL10(1), CARD11(10), CBL(3), CBLB(4), CBLC(2), CD28(1), CD3E(2), CD3G(2), CD8A(1), CDC42(1), CDK4(6), CHUK(2), CTLA4(3), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(3), IKBKB(3), IKBKG(1), IL4(1), ITK(2), JUN(2), KRAS(3), LAT(1), LCK(1), LCP2(3), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKCQ(5), PTPN6(3), PTPRC(8), RASGRP1(3), SOS1(9), SOS2(7), TEC(6), TNF(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1)	97655632	236	178	225	46	21	31	33	95	56	0	0.0265	1.000	1.000
428	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(7), ADCY3(7), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(13), ADCY9(7), ASIP(1), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(10), CTNNB1(2), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(16), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GNAI1(2), GNAI2(2), GNAI3(2), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KIT(3), KITLG(2), KRAS(3), LEF1(3), MAP2K2(1), MAPK3(3), MITF(5), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), POMC(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), TCF7L1(2), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1)	106042160	238	178	230	62	30	29	27	99	53	0	0.190	1.000	1.000
429	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(9), ACTN1(1), ACTR2(2), AKT1(3), AKT2(5), AKT3(3), ARHGEF6(4), ARHGEF7(5), BCAR1(6), BRAF(4), CDC42(1), CSE1L(4), DOCK1(3), EPHB2(2), FYN(2), GRB2(2), GRB7(5), GRLF1(6), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGB3BP(1), MAP2K7(1), MAP3K11(2), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), P4HB(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CB(5), PKLR(1), PLCG1(4), PLCG2(4), PTK2(3), RAF1(4), RALA(2), RHO(1), ROCK1(5), ROCK2(4), SHC1(4), SOS1(9), SOS2(7), SRC(4), TLN1(14), TLN2(12), WAS(1), ZYX(1)	118716011	252	174	245	74	18	39	37	99	55	4	0.618	1.000	1.000
430	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(3), CLK2(2), CLK3(2), CLK4(5), COL2A1(6), CPSF1(4), CPSF2(2), CPSF3(5), CPSF4(2), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(7), DHX15(3), DHX16(2), DHX38(3), DHX8(3), DHX9(7), DICER1(4), FUS(6), GIPC1(3), LOC440563(2), LSM7(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(4), PHF5A(1), POLR2A(13), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4B(7), PRPF8(15), PSKH1(2), PTBP1(1), PTBP2(1), RBM17(3), RBM5(2), RNMT(4), RNPS1(1), SF3A1(2), SF3A3(2), SF3B1(16), SF3B2(5), SF3B4(1), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPA(1), SNRPB(3), SNRPB2(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(5), SUPT5H(9), TXNL4A(1), U2AF2(3), XRN2(4)	105751759	211	172	206	51	18	44	22	82	44	1	0.155	1.000	1.000
431	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(2), ADCY8(13), ARAF(1), ATF4(2), BRAF(4), CACNA1C(18), CALM2(1), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(10), EP300(16), GRIA1(8), GRIA2(4), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRM1(5), GRM5(9), HRAS(1), ITPR1(7), ITPR2(13), ITPR3(5), KRAS(3), MAP2K2(1), MAPK3(3), NRAS(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R1A(1), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), RAP1A(1), RAPGEF3(3), RPS6KA3(3), RPS6KA6(1)	99425787	222	171	213	57	30	33	24	88	46	1	0.142	1.000	1.000
432	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(8), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C2(2), C3(8), C3AR1(3), C4BPA(3), C4BPB(3), C5(6), C5AR1(3), C6(3), C7(4), C8A(1), C8B(2), C8G(2), CD46(1), CD55(2), CD59(1), CFB(6), CFH(6), CFI(2), CPB2(6), CR1(8), CR2(4), F10(1), F11(2), F12(7), F13A1(3), F13B(4), F2(4), F2R(2), F5(12), F7(1), F8(8), F9(2), FGA(4), FGB(2), FGG(6), KLKB1(2), KNG1(4), MASP1(4), MASP2(1), MBL2(2), PLAT(4), PLAU(5), PLAUR(2), PLG(8), PROC(4), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(3), TFPI(2), THBD(1), VWF(15)	88615845	220	168	212	46	24	27	25	95	47	2	0.0290	1.000	1.000
433	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(4), ALG14(1), ALG3(3), ALG6(3), ALG8(2), ALG9(2), B3GNT1(2), B3GNT2(3), B3GNT6(4), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(2), CHST3(2), CHST4(1), CHST6(2), CHST7(2), DPAGT1(8), EXT1(4), EXT2(1), EXTL1(1), EXTL3(3), FUT11(4), GALNT1(1), GALNT10(7), GALNT11(4), GALNT13(3), GALNT14(3), GALNT2(3), GALNT4(1), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), NDST1(2), NDST2(4), NDST3(1), NDST4(7), OGT(5), RPN1(3), RPN2(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(6), XYLT1(5), XYLT2(2)	105724635	229	167	222	70	22	37	29	76	65	0	0.665	1.000	1.000
434	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(7), BAD(1), CABIN1(11), CALM2(1), CAMK2B(1), CAMK4(3), CD3E(2), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(10), CSNK2A1(3), CSNK2B(1), CTLA4(3), EGR2(1), EGR3(2), EP300(16), FOS(1), GATA3(2), GATA4(2), GRLF1(6), GSK3A(3), GSK3B(3), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(3), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(3), MEF2D(1), NCK2(2), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(8), OPRD1(3), P2RX7(2), PAK1(3), PPIA(1), PPP3CC(3), PTPRC(8), RELA(6), SFN(1), SLA(1), SP1(2), SP3(2), TNF(1), TRAF2(1), TRPV6(5), VAV1(4), VAV2(4), VAV3(1), XPO5(3)	89449954	211	161	199	50	20	25	32	72	60	2	0.186	1.000	1.000
435	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(10), CD19(1), CD1A(1), CD1B(1), CD1C(2), CD1D(3), CD1E(2), CD2(2), CD22(4), CD24(1), CD33(2), CD34(2), CD36(1), CD38(1), CD3E(2), CD3G(2), CD44(3), CD5(1), CD55(2), CD59(1), CD8A(1), CR1(8), CR2(4), CSF1R(8), CSF2RA(5), CSF3R(4), DNTT(4), EPOR(3), FCER2(1), FCGR1A(2), FLT3(6), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(8), IL2RA(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL7R(1), IL9R(6), ITGA1(8), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(3), KIT(3), KITLG(2), MME(6), MS4A1(1), TFRC(3), THPO(1), TNF(1), TPO(4)	80607770	208	157	198	45	17	22	30	79	59	1	0.136	1.000	1.000
436	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(4), ACVR2B(1), ACVRL1(1), BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CHRD(5), CREBBP(10), CUL1(5), DCN(3), E2F5(1), EP300(16), GDF5(5), GDF6(2), GDF7(1), INHBA(2), INHBB(2), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(7), MAPK3(3), MYC(2), NODAL(2), NOG(2), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(4), PPP2R2C(3), RBL2(5), RBX1(1), ROCK1(5), ROCK2(4), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(2), SMAD3(2), SMAD4(3), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(1), SMURF2(4), SP1(2), TGFB2(3), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS2(3), THBS3(7), THBS4(4), TNF(1), ZFYVE16(1), ZFYVE9(7)	93514179	195	155	190	47	21	21	33	69	51	0	0.121	1.000	1.000
437	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(9), ATM(20), BUB1(2), BUB1B(1), BUB3(1), CCNA1(8), CCNB1(1), CCNB2(6), CCNB3(6), CCND2(1), CCNE1(3), CCNE2(4), CCNH(1), CDAN1(6), CDC14A(5), CDC14B(1), CDC20(3), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDH1(2), CDK2(2), CDK4(6), CDKN1A(3), CHEK1(1), CHEK2(2), DTX4(5), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(16), ESPL1(13), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MPEG1(1), ORC1L(1), ORC2L(1), PCNA(4), PLK1(1), PRKDC(13), PTPRA(5), PTTG2(1), RB1(4), SKP2(1), SMAD4(3), TBC1D8(1), WEE1(2)	109835501	220	151	207	60	22	28	36	73	57	4	0.280	1.000	1.000
438	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(6), AKT1(3), AKT2(5), AKT3(3), APAF1(3), ATM(20), BAD(1), BAX(1), BID(2), BIRC2(3), BIRC3(5), CAPN1(3), CAPN2(4), CASP10(4), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CSF2RB(5), DFFA(1), DFFB(1), FAS(2), FASLG(3), IKBKB(3), IKBKG(1), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), MAP3K14(2), NFKB1(2), NFKB2(3), NFKBIA(2), NTRK1(8), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKACA(2), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF1A(1), TRADD(2), TRAF2(1)	80167084	182	149	175	40	20	23	24	74	40	1	0.0961	1.000	1.000
439	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(2), BRAF(4), CHUK(2), DAXX(6), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(4), MAP2K5(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP3K9(6), MAP4K1(5), MAP4K2(1), MAP4K3(6), MAP4K4(2), MAP4K5(4), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(2), MAPK6(1), MAPK7(4), MAPK9(2), MAPKAPK2(1), MAPKAPK5(1), MAX(5), MEF2A(3), MEF2D(1), MKNK1(2), MKNK2(1), MYC(2), NFKB1(2), NFKBIA(2), PAK1(3), PAK2(4), RAC1(1), RAF1(4), RELA(6), RIPK1(1), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KB1(2), RPS6KB2(2), SHC1(4), SP1(2), STAT1(6), TGFB2(3), TGFB3(1), TGFBR1(1), TRADD(2), TRAF2(1)	94445350	193	143	186	44	19	20	22	76	53	3	0.221	1.000	1.000
440	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(5), AKT3(3), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(3), IKBKB(3), IKBKE(3), IKBKG(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), RAC1(1), RELA(6), RIPK1(1), SPP1(3), STAT1(6), TBK1(3), TICAM1(3), TLR1(3), TLR2(2), TLR3(1), TLR4(3), TLR5(4), TLR6(2), TLR7(6), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2)	86343029	170	141	165	39	18	21	22	79	28	2	0.131	1.000	1.000
441	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(3), AKT2(5), AKT3(3), CAMKK1(4), CAMKK2(3), CD36(1), CHUK(2), CPT1A(2), CPT1C(4), CPT2(2), G6PC(3), IKBKB(3), IKBKG(1), IRS1(5), IRS4(1), JAK1(7), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NPY(1), PCK1(5), PCK2(2), POMC(2), PPARGC1A(4), PRKAA1(1), PRKAB1(1), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKCQ(5), PTPN11(2), RELA(6), RXRB(4), RXRG(2), SLC2A1(2), SLC2A4(3), SOCS3(1), STAT3(3), STK11(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TYK2(7)	78519789	167	136	161	45	14	23	29	57	43	1	0.439	1.000	1.000
442	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(5), AKT3(3), BCL10(1), BLNK(1), BTK(1), CARD11(10), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), IKBKG(1), INPP5D(2), JUN(2), KRAS(3), LILRB3(5), LYN(1), MALT1(3), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PTPN6(3), RAC1(1), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(4), VAV2(4), VAV3(1)	71797497	160	133	150	41	18	19	16	66	41	0	0.376	1.000	1.000
443	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	57	AKT1(3), AKT2(5), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN1B(1), CREB3(2), CREB5(3), ERBB4(11), F2RL2(2), GAB1(2), GRB2(2), GSK3A(3), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), MYC(2), NOLC1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARD3(6), PDK1(1), PIK3CD(2), PPP1R13B(4), PREX1(8), PTK2(3), PTPN1(2), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SOS1(9), SOS2(7), TSC1(6), TSC2(13), YWHAE(1)	67270759	153	130	149	40	18	21	28	50	34	2	0.240	1.000	1.000
444	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(3), AKT2(5), AKT3(3), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(3), MAP2K2(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(10), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NOS3(4), NRAS(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PPP3R2(2), PRKCA(2), PRKCG(6), PTGS2(5), PTK2(3), PXN(3), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SH2D2A(3), SHC2(4), SPHK1(2), SPHK2(1), SRC(4)	68975748	161	128	154	47	16	22	21	67	35	0	0.578	1.000	1.000
445	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(3), AKT2(5), AKT3(3), BTK(1), FCER1G(1), FYN(2), GAB2(2), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(3), LAT(1), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(2), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(4), PLCG2(4), PRKCA(2), PRKCD(5), PRKCE(4), RAC1(1), RAC2(1), RAC3(1), RAF1(4), SOS1(9), SOS2(7), SYK(2), TNF(1), VAV1(4), VAV2(4), VAV3(1)	69832961	141	125	137	44	14	24	21	60	22	0	0.541	1.000	1.000
446	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(3), ENTPD6(2), NME7(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5C3(1), NT5M(2), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(3), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(7), RFC5(3), RRM1(3), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP1(2), UPP2(2), UPRT(3)	81728932	155	124	145	38	12	24	18	53	46	2	0.248	1.000	1.000
447	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(2), APH1A(1), CREBBP(10), CTBP1(2), CTBP2(3), DLL1(1), DLL3(1), DLL4(2), DTX1(5), DTX3(1), DTX3L(2), DTX4(5), DVL1(1), DVL2(1), EP300(16), HDAC1(2), JAG1(9), JAG2(4), MAML1(9), MAML2(6), MAML3(10), NCOR2(7), NCSTN(2), NOTCH1(12), NOTCH2(13), NOTCH3(11), NOTCH4(6), NUMB(3), NUMBL(1), PSEN2(3), PSENEN(1), PTCRA(2), RBPJ(3), SNW1(3)	65175755	160	122	154	78	15	20	20	51	50	4	1.000	1.000	1.000
448	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(5), AKT3(3), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(3), GSK3B(3), INPP5D(2), ITPR1(7), ITPR2(13), ITPR3(5), LYN(1), MAP4K1(5), MAPK3(3), NFATC1(4), NFATC2(8), PDK1(1), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), PPP3CA(3), PPP3CC(3), PTPRC(8), RAF1(4), SHC1(4), SOS1(9), SOS2(7), SYK(2), VAV1(4)	70970293	151	121	145	35	16	20	23	52	40	0	0.131	1.000	1.000
449	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(8), ATP4A(6), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(1), ATP5G2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), COX10(5), COX15(3), COX17(1), COX5A(1), COX6A2(1), COX6B2(1), COX7A1(2), COX7A2(1), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(2), NDUFA11(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB10(1), NDUFB11(1), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFC1(2), NDUFS1(7), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(2), PPA2(2), SDHA(9), SDHB(1), SDHD(2), TCIRG1(2), UQCRC1(1), UQCRC2(2), UQCRFS1(2)	55948858	139	120	137	37	13	18	24	57	26	1	0.339	1.000	1.000
450	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(6), ATP13A2(8), DDX18(4), DDX23(3), DDX4(5), DDX41(3), DDX47(3), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(4), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), FPGS(3), GGH(2), IFIH1(4), MOV10L1(6), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SKIV2L2(2), SMARCA2(5), SMARCA5(4)	62195910	143	119	140	42	10	26	28	46	32	1	0.330	1.000	1.000
451	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(2), ALG6(3), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CELSR1(18), CELSR2(9), CELSR3(10), CHRM2(6), CHRM3(3), CIDEB(2), EMR2(4), EMR3(9), F2R(2), FSHR(2), GPR116(5), GPR133(7), GPR135(2), GPR17(2), GPR18(2), GPR55(1), GPR56(1), GPR61(1), GPR77(1), GPR84(4), GRM1(5), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(10), LTB4R2(1), NTSR1(3), OR8G1(2), OR8G2(2), P2RY13(1), PTGFR(5), SMO(4), SSTR2(2), TSHR(2)	64070642	151	118	145	48	23	21	17	59	31	0	0.604	1.000	1.000
452	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ACCN1(2), ADCY4(3), ADCY6(2), ADCY8(13), CACNA1A(14), CACNA1B(5), GNAS(5), GNB1(3), GNB3(2), GNG3(1), GRM4(6), ITPR3(5), KCNB1(2), PDE1A(1), PLCB2(4), PRKACA(2), PRKACB(5), PRKACG(3), PRKX(2), SCNN1A(4), SCNN1B(4), SCNN1G(2), TAS1R1(2), TAS1R2(9), TAS1R3(3), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R14(1), TAS2R16(1), TAS2R38(4), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R46(2), TAS2R50(2), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3)	55407578	131	116	129	36	32	15	14	44	26	0	0.229	1.000	1.000
453	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(3), CALR(2), CANX(2), CD74(1), CD8A(1), CIITA(5), CTSB(4), CTSL1(3), CTSS(1), HLA-A(6), HLA-B(10), HLA-C(10), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(10), HLA-E(2), HLA-F(2), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL1(1), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC1(3), KLRC2(5), KLRC3(1), LTA(1), NFYA(1), NFYC(2), PSME2(3), RFX5(2), RFXAP(1), TAP1(1), TAP2(1)	42078792	146	115	144	51	8	25	17	62	33	1	0.909	1.000	1.000
454	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5E(3), INPPL1(4), IPMK(1), ITPK1(2), ITPKA(2), ITPKB(2), MINPP1(2), MIOX(2), OCRL(3), PI4KA(10), PI4KB(3), PIK3C3(4), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(5), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PTPMT1(2), SYNJ1(6), SYNJ2(6)	70947574	139	114	133	45	13	18	14	52	41	1	0.851	1.000	1.000
455	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(2), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1E(3), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(2), GLI1(7), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(25), PRKACA(2), PRKACB(5), PRKACG(3), PRKX(2), PTCH1(11), PTCH2(2), SHH(3), SMO(4), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1), ZIC2(1)	57495139	135	114	127	40	18	18	14	52	33	0	0.651	1.000	1.000
456	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ADAM17(2), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1B1(6), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(2), CSK(4), CXCL1(1), EGFR(10), F11R(1), GIT1(4), IGSF5(5), IKBKB(3), IKBKG(1), JAM3(1), JUN(2), LYN(1), MAP3K14(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(3), PLCG1(4), PLCG2(4), PTPN11(2), PTPRZ1(15), RAC1(1), RELA(6), SRC(4), TCIRG1(2), TJP1(6)	67961641	142	114	133	40	14	19	18	58	31	2	0.638	1.000	1.000
457	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(4), CPEB1(3), EGFR(10), ERBB2(8), ERBB4(11), ETS1(2), ETS2(1), ETV6(2), FMN2(9), GRB2(2), KRAS(3), MAPK3(3), NOTCH1(12), NOTCH2(13), NOTCH3(11), NOTCH4(6), PIWIL1(2), PIWIL2(2), PIWIL3(4), PIWIL4(3), RAF1(4), SOS1(9), SOS2(7), SPIRE1(1), SPIRE2(2)	50297264	134	113	130	37	21	15	20	47	28	3	0.458	1.000	1.000
458	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	91	ANK2(18), B3GALT4(1), CDR1(4), DGKI(1), FAU(3), IL6ST(6), PIGK(1), RPL10(1), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL23(1), RPL24(1), RPL26(1), RPL27(2), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(3), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS19(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPS8(1), RPS9(1), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(4)	50008845	121	110	118	33	8	13	24	46	29	1	0.484	1.000	1.000
459	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(20), CCNA1(8), CCNB1(1), CCND2(1), CCNE1(3), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2C(1), CREB3(2), CREB3L1(1), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(5), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MNAT1(1), MYC(2), MYT1(5), ORC1L(1), ORC2L(1), PCNA(4), POLE(5), POLE2(1), PRIM1(3), RB1(4), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(11), WEE1(2)	70391464	145	108	136	34	17	15	19	50	41	3	0.207	1.000	1.000
460	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(3), ACADL(3), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(3), APOA1(1), APOA2(1), APOA5(2), CD36(1), CPT1A(2), CPT1C(4), CPT2(2), CYP27A1(1), CYP4A11(5), CYP4A22(2), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(3), HMGCS2(1), ILK(4), LPL(3), ME1(1), MMP1(2), NR1H3(3), PCK1(5), PCK2(2), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(3), SLC27A1(4), SLC27A2(1), SLC27A5(3), SLC27A6(7), SORBS1(3), UBC(4), UCP1(1)	62411596	129	107	123	42	11	19	17	48	33	1	0.821	1.000	1.000
461	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(1), BAX(1), BFAR(2), BTK(1), CAD(13), CASP10(4), CASP8(1), CASP8AP2(7), CSNK1A1(2), DAXX(6), DEDD(3), DFFA(1), DIABLO(1), EGFR(10), EPHB2(2), FAIM2(1), MAP2K7(1), MAP3K1(8), MAP3K5(5), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NFAT5(10), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PFN2(1), PTPN13(9), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(6), TPX2(2), TRAF2(1)	69095136	129	107	121	33	17	14	13	52	32	1	0.384	1.000	1.000
462	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(3), APAF1(3), ARHGDIB(1), BAG4(1), BID(2), BIRC2(3), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(5), LMNB1(3), LMNB2(1), MAP2K7(1), MAP3K1(8), MAP3K14(2), MAP3K5(5), NFKB1(2), NFKBIA(2), NUMA1(7), PAK2(4), PRKCD(5), PRKDC(13), PSEN2(3), PTK2(3), RASA1(7), RB1(4), RELA(6), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	69400667	134	104	131	39	6	26	19	42	38	3	0.565	1.000	1.000
463	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	61	ACSS1(4), ACSS2(7), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1B1(4), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GALM(3), GAPDH(4), GAPDHS(5), GCK(2), HK1(5), LDHAL6B(1), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM1(1), PGAM2(2), PGK1(3), PGK2(1), PGM1(1), PKLR(1), PKM2(1), TPI1(2)	54752430	118	103	112	32	11	7	18	43	37	2	0.530	1.000	1.000
464	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), AXIN1(5), CCND2(1), CSNK1E(3), CTNNB1(2), DVL1(1), DVL2(1), FZD1(4), FZD10(4), FZD2(2), FZD3(1), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LDLR(3), MAPK10(2), MAPK9(2), MYC(2), PAFAH1B1(1), PLAU(5), PPP2R5C(3), PPP2R5E(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(2), PRKD1(4), RAC1(1), SFRP4(2), WNT1(2), WNT10A(3), WNT10B(1), WNT11(2), WNT2(2), WNT2B(2), WNT3(3), WNT5B(2), WNT7B(1)	57268066	118	103	114	31	15	17	11	42	33	0	0.276	1.000	1.000
465	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	53	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AGK(6), AGPAT1(1), AGPAT6(1), AKR1A1(2), AKR1B1(3), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), CEL(3), DAK(3), DGAT1(2), DGAT2(1), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), GK(1), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(7), LIPA(1), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNLIPRP2(1), PNPLA3(3), PPAP2B(1), PPAP2C(3)	56894601	118	102	117	30	14	16	17	45	26	0	0.193	1.000	1.000
466	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), APOA1(1), APOA2(1), CD36(1), CITED2(1), CREBBP(10), EHHADH(6), EP300(16), FABP1(3), HSD17B4(2), INS(1), JUN(2), LPL(3), MAPK3(3), ME1(1), MRPL11(1), MYC(2), NCOA1(4), NCOR1(7), NCOR2(7), NFKBIA(2), NR1H3(3), NR2F1(1), NRIP1(7), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PTGS2(5), RB1(4), RELA(6), SP1(2), SRA1(1), STAT5A(3), STAT5B(3), TNF(1)	60371809	133	101	124	47	8	18	16	50	38	3	0.939	1.000	1.000
467	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(5), AKT3(3), ASAH1(3), BRAF(4), DAG1(3), DRD2(1), EGFR(10), EPHB2(2), GRB2(2), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), PI3(1), PIK3CB(5), PITX2(2), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), RAF1(4), RGS20(1), SHC1(4), SOS1(9), SOS2(7), SRC(4), STAT3(3)	58297991	127	101	125	30	13	19	22	47	25	1	0.123	1.000	1.000
468	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH3B1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(4), CYP1B1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(6), EPHX1(6), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(3), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6)	56750140	120	99	118	33	15	11	20	46	28	0	0.419	1.000	1.000
469	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	55	AADAT(2), ABP1(5), ACAT1(1), ACMSD(2), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(2), AOX1(8), CAT(2), CYP1A1(1), CYP1A2(4), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), HAAO(2), HADH(1), HADHA(4), HSD17B4(2), KYNU(3), LCMT1(1), LCMT2(4), LNX1(1), MAOA(2), MAOB(2), METTL2B(1), NFX1(3), OGDH(8), OGDHL(2), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), TPH1(2), TPH2(2), WARS(1), WARS2(4)	57431506	113	97	110	28	10	18	22	43	20	0	0.140	1.000	1.000
470	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), AKT1(3), AKT2(5), AKT3(3), ARHGAP1(1), ARHGEF11(5), BTK(1), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(7), ITPR2(13), ITPR3(5), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDK1(1), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(4), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(4), SAG(4), WASF1(1), WASL(7)	65984978	119	97	118	31	12	26	14	44	23	0	0.226	1.000	1.000
471	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT1(3), AKT2(5), AKT3(3), BRD4(5), CAP1(3), CBL(3), CDC42(1), F2RL2(2), FLOT1(1), FLOT2(1), GRB2(2), GSK3A(3), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), LNPEP(4), MAPK3(3), PARD3(6), PDK1(1), PIK3CD(2), PIK3R1(5), PTPN1(2), RAF1(4), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SORBS1(3), SOS1(9), SOS2(7), YWHAE(1)	52288483	106	95	102	29	11	14	21	37	23	0	0.454	1.000	1.000
472	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT6(1), CDS2(2), CHAT(5), CHKB(2), CHPT1(3), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), ESCO1(2), ESCO2(1), ETNK1(3), ETNK2(1), GPAM(5), GPD1(1), GPD1L(3), GPD2(1), LCAT(5), LYPLA1(1), MYST3(4), MYST4(3), PCYT1A(1), PCYT1B(1), PISD(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(7), PNPLA3(3), PPAP2B(1), PPAP2C(3), PTDSS1(2), SH3GLB1(3)	65536580	117	94	112	31	16	15	15	39	32	0	0.313	1.000	1.000
473	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM2(1), CD3E(2), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), LAT(1), LCK(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3R1(5), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PTPN7(1), RAC1(1), RAF1(4), RASA1(7), RELA(6), SHC1(4), SOS1(9), SYT1(1), VAV1(4), ZAP70(1)	44851586	108	93	102	27	12	19	8	34	34	1	0.482	1.000	1.000
474	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(5), BLVRA(1), COX10(5), COX15(3), CP(4), CPOX(6), EPRS(5), FECH(2), FTMT(5), GUSB(7), HCCS(1), HMOX1(3), HMOX2(1), MMAB(1), PPOX(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UROD(2)	42004357	104	92	96	31	10	9	17	42	26	0	0.722	1.000	1.000
475	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(2), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(3), JUN(2), MAP2K5(4), MAP2K7(1), MAP3K1(8), MAP3K10(4), MAP3K11(2), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAP3K9(6), MAPK10(2), MAPK7(4), MAPK9(2), MYEF2(1), NFATC3(7), NR2C2(1), PAPPA(4), SHC1(4), TRAF6(2), ZAK(4)	48939164	104	92	99	29	7	13	14	45	23	2	0.552	1.000	1.000
476	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAD(1), BAK1(1), BAX(1), BCL2L11(1), BID(2), BIRC2(3), BIRC3(5), BIRC5(1), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(3), HELLS(4), IKBKB(3), IKBKG(1), IRF2(2), IRF5(3), IRF6(6), IRF7(1), JUN(2), LTA(1), MAP3K1(8), MAPK10(2), MYC(2), NFKB1(2), NFKBIA(2), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TP73(4), TRADD(2), TRAF2(1), TRAF3(1)	55175807	109	91	102	33	8	18	18	34	30	1	0.696	1.000	1.000
477	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(10), EEF1A2(3), EEF1B2(3), EEF1D(2), EEF1G(2), EEF2(2), EEF2K(4), EIF1AX(1), EIF2AK1(5), EIF2AK2(4), EIF2AK3(3), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G3(7), EIF5(3), EIF5A(2), EIF5B(2), ETF1(3), GSPT2(1), KIAA0664(3), PABPC3(17), PAIP1(3), SLC35A4(2)	42628211	106	91	102	35	12	18	18	36	21	1	0.605	1.000	1.000
478	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(2), DAXX(6), EGF(5), EGFR(10), ETS1(2), ETS2(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), JUN(2), MAP2K3(4), MAP2K6(1), MAP2K7(1), MAP3K1(8), MAP3K14(2), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(3), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), RAF1(4), RELA(6), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(1)	48453273	108	90	102	27	14	11	5	41	36	1	0.584	1.000	1.000
479	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(7), AMY2A(1), AMY2B(2), ENPP1(4), ENPP3(2), G6PC(3), GAA(3), GBA3(3), GBE1(2), GCK(2), GUSB(7), GYS1(3), GYS2(3), HK1(5), MGAM(9), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4), UXS1(1)	56341088	106	90	103	34	11	10	19	40	26	0	0.741	1.000	1.000
480	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	29	AKT1(3), AKT2(5), AKT3(3), BCR(2), BTK(1), CD19(1), DAPP1(2), FLOT1(1), FLOT2(1), GAB1(2), ITPR1(7), ITPR2(13), ITPR3(5), LYN(1), PDK1(1), PHF11(2), PITX2(2), PLCG2(4), PPP1R13B(4), PREX1(8), PTPRC(8), RPS6KA3(3), RPS6KB1(2), SAG(4), SYK(2), TEC(6), VAV1(4)	50477315	97	89	97	29	7	17	14	38	21	0	0.416	1.000	1.000
481	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(3), ATF1(2), BRAF(4), CAMP(1), CREB3(2), CREB5(3), CREBBP(10), CRKL(1), DAG1(3), EGR2(1), EGR3(2), EGR4(1), ELK1(1), FRS2(2), JUN(2), MAP1B(12), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NTRK1(8), PIK3C2G(5), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(4), SRC(4), TH(4)	47522751	105	89	103	31	15	22	13	35	19	1	0.357	1.000	1.000
482	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(7), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(4), TLR4(3), TLR5(4), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4), WAS(1), WASL(7)	50890196	111	87	110	49	13	23	23	31	21	0	0.971	1.000	1.000
483	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(7), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(4), TLR4(3), TLR5(4), TUBA1A(3), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB8(4), WAS(1), WASL(7)	50890196	111	87	110	49	13	23	23	31	21	0	0.971	1.000	1.000
484	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(6), BCR(2), CAPN1(3), CRKL(1), CSK(4), FYN(2), GRB2(2), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAPK3(3), PPP1R12B(2), PTK2(3), PXN(3), RAF1(4), RAP1A(1), ROCK1(5), SHC1(4), SOS1(9), SRC(4), TLN1(14), VCL(2), ZYX(1)	46700891	100	87	99	27	8	14	8	45	24	1	0.566	1.000	1.000
485	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	51	ABP1(5), ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), AOC2(5), AOC3(2), AOX1(8), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(4), CYP4F8(1), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(2), TPH1(2), WARS(1), WARS2(4)	51878833	111	87	108	29	16	14	15	50	16	0	0.210	1.000	1.000
486	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(2), AGXT2(2), ALAS1(5), ALAS2(5), AOC2(5), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(5), GATM(2), GLDC(4), MAOA(2), MAOB(2), PISD(2), PLCB2(4), PLCG1(4), PLCG2(4), SARDH(5), SARS(3), SHMT1(2), SHMT2(5), TARS(6)	41967764	96	86	92	26	10	14	18	31	22	1	0.347	1.000	1.000
487	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(3), AKT2(5), AKT3(3), ARHGEF11(5), CDC42(1), DLG4(2), GNA13(4), IKBKG(1), LPA(9), MAP3K1(8), MAP3K5(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(5), PLD1(3), PLD2(7), PLD3(3), PTK2(3), RDX(2), ROCK1(5), ROCK2(4), SRF(1), TBXA2R(4)	48951973	101	86	97	30	13	12	12	42	22	0	0.590	1.000	1.000
488	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), F10(1), F11(2), F12(7), F2(4), F2R(2), F5(12), F8(8), F9(2), FGA(4), FGB(2), FGG(6), KLKB1(2), PROC(4), PROS1(5), SERPING1(3)	44687494	96	85	94	30	12	17	10	34	22	1	0.482	1.000	1.000
489	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS(6), CARS2(3), DARS(3), DARS2(1), EPRS(5), FARSA(2), HARS(1), HARS2(1), IARS(4), IARS2(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(4), MTFMT(1), NARS2(6), PARS2(3), QARS(1), RARS(3), RARS2(2), SARS(3), SARS2(1), TARS(6), TARS2(7), VARS(4), VARS2(6), WARS(1), WARS2(4), YARS(1), YARS2(1)	53298830	103	84	97	29	3	16	11	47	26	0	0.607	1.000	1.000
490	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(2), F12(7), F13B(4), F2(4), F5(12), F7(1), F8(8), F9(2), FGA(4), FGB(2), FGG(6), LPA(9), PLAT(4), PLAU(5), PLG(8), SERPINB2(1), SERPINF2(2), VWF(15)	34880438	97	81	93	33	9	9	16	35	26	2	0.771	1.000	1.000
491	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPS(5), CDS2(2), CHAT(5), CHKB(2), CLC(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), ETNK1(3), GPD1(1), GPD2(1), LCAT(5), LGALS13(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PCYT1B(1), PISD(2), PLA2G4A(2), PLA2G6(5), PLCB2(4), PLCG1(4), PLCG2(4), PPAP2B(1), PPAP2C(3)	49908150	95	81	91	27	15	16	10	29	25	0	0.346	1.000	1.000
492	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GAPDHS(5), GCK(2), GOT1(3), GOT2(2), HK1(5), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PFKL(3), PFKM(3), PFKP(3), PGAM1(1), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), PKM2(1), TNFAIP1(1), TPI1(2)	40784007	97	81	94	28	6	8	14	28	40	1	0.661	1.000	1.000
493	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	50	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GCK(2), HK1(5), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGAM1(1), PGK1(3), PGM1(1), PKLR(1), PKM2(1), TPI1(2)	45443899	92	80	88	29	10	3	14	37	27	1	0.780	1.000	1.000
494	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	43	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), CEL(3), DGAT1(2), DGKA(4), DGKB(4), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), GK(1), GLA(1), GLB1(5), LCT(7), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNLIPRP2(1), PPAP2B(1), PPAP2C(3)	46337316	94	80	93	28	14	13	12	34	21	0	0.453	1.000	1.000
495	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	50	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ALDH3B1(4), ALDH3B2(3), ALDOA(3), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(2), ENO3(2), FBP1(1), G6PC(3), GAPDH(4), GCK(2), HK1(5), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGAM1(1), PGK1(3), PGM1(1), PKLR(1), PKM2(1), TPI1(2)	45443899	92	80	88	29	10	3	14	37	27	1	0.780	1.000	1.000
496	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSD(3), ARSE(2), CYP11B1(3), CYP11B2(2), CYP19A1(2), HSD11B2(1), HSD17B1(1), HSD17B2(1), HSD17B7(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6)	49477840	89	80	89	26	7	7	19	29	27	0	0.559	1.000	1.000
497	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	ABO(1), B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(3), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALNT1(1), B4GALT1(1), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GBGT1(2), PIGB(2), PIGC(1), PIGF(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(6), PIGS(2), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	45588632	96	80	90	30	14	15	10	28	28	1	0.679	1.000	1.000
498	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	41	ABP1(5), AGMAT(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), ALDH4A1(2), AMD1(2), AOC2(5), AOC3(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(6), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(2), MAOB(2), NOS1(10), NOS3(4), OAT(2), ODC1(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), P4HB(2), PYCR1(1), RARS(3), SMS(2)	41932751	88	79	88	26	8	5	19	34	21	1	0.586	1.000	1.000
499	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), CALM2(1), ELK1(1), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP2K7(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PAK2(4), PIK3R1(5), PLA2G4A(2), PLCG1(4), PPP3CA(3), PPP3CC(3), RAF1(4), SHC1(4), SOS1(9), SYK(2), SYT1(1), VAV1(4)	40063381	90	79	87	30	10	11	9	32	28	0	0.854	1.000	1.000
500	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(2), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(4), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR77(1), GRPR(2), MC2R(3), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(2), NPY2R(2), NTSR1(3), OPRD1(3), OPRK1(2), OPRM1(3), OXTR(1), SSTR1(4), SSTR2(2), SSTR3(2), SSTR4(3), TACR1(2), TACR2(2), TACR3(2), TRHR(2), TSHR(2)	50346108	93	77	93	34	18	11	12	39	13	0	0.641	1.000	1.000
501	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(3), APC(9), ASAH1(3), CAMP(1), CAV3(1), DAG1(3), DLG4(2), EPHB2(2), GNAI1(2), ITPR1(7), ITPR2(13), ITPR3(5), KCNJ3(4), PITX2(2), RAC1(1), RHO(1), RYR1(23)	45473864	82	77	82	20	14	11	15	29	13	0	0.160	1.000	1.000
502	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), BTG1(3), CBX3(1), CLOCK(4), CRY1(1), EIF4G2(4), ETV6(2), GSTP1(2), HERPUD1(3), HSPA8(8), IDI1(1), KLF9(2), MYF6(3), NCKAP1(3), NCOA4(7), NR1D2(2), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(2), PSMA4(2), SF3A3(2), TOB1(5), TUBB3(3), UGP2(1), ZFR(8)	36283558	86	76	85	28	4	12	17	32	19	2	0.747	1.000	1.000
503	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(2), ALOX15B(3), ALOX5(4), CBR1(4), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(5), CYP4A22(2), CYP4F2(4), CYP4F3(2), DHRS4(3), EPHX2(1), GGT1(4), GPX1(2), GPX3(3), GPX4(2), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4)	38801290	84	76	81	21	10	9	18	31	15	1	0.225	1.000	1.000
504	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CREBBP(10), EP300(16), ERCC3(4), GRIP1(3), GTF2A1(2), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), NCOR2(7), NRIP1(7), PELP1(1), POLR2A(13), SRA1(1), TBP(1)	46262931	85	75	81	45	6	10	14	31	24	0	0.998	1.000	1.000
505	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	35	ANAPC1(4), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), BTRC(2), CDC16(4), CDC20(3), CDC23(2), CUL1(5), CUL2(4), FBXW11(2), FBXW7(6), FZR1(4), RBX1(1), SKP2(1), SMURF2(4), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), WWP1(8), WWP2(4)	36973769	80	75	76	22	8	8	16	26	21	1	0.548	1.000	1.000
506	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(5), AKT3(3), ANKRD6(2), APC(9), AXIN1(5), AXIN2(1), CER1(1), CSNK1A1(2), CTNNB1(2), DACT1(2), DKK2(1), DVL1(1), FSTL1(2), GSK3A(3), GSK3B(3), LRP1(15), MVP(5), NKD1(4), NKD2(4), PTPRA(5), SENP2(1), WIF1(5)	40007373	84	75	79	21	7	12	12	31	22	0	0.283	1.000	1.000
507	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(2), CDC7(2), CDK2(2), CDT1(2), DIAPH2(2), MCM10(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), ORC1L(1), ORC2L(1), PCNA(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), PRIM1(3), RFC1(6), RFC2(1), RFC4(2), RFC5(3), RPA1(2), RPA2(1), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(4)	46885015	88	74	85	27	11	9	11	34	23	0	0.686	1.000	1.000
508	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	40	ACACA(8), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(4), ACSS2(7), ACYP1(1), AKR1B1(3), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1), PKM2(1)	44523825	85	74	83	24	5	10	17	23	28	2	0.598	1.000	1.000
509	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(1), CRKL(1), DOCK1(3), ELK1(1), FOS(1), GAB1(2), GRB2(2), HGF(1), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAP4K1(5), MAPK3(3), PAK1(3), PIK3R1(5), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAF1(4), RAP1A(1), RASA1(7), SOS1(9), SRC(4), STAT3(3)	39125202	86	74	85	24	5	18	8	30	25	0	0.638	1.000	1.000
510	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(20), ATR(12), BRCA1(9), BRCA2(14), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(1), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(3), RAD17(2), RAD50(4), RAD51(2), TREX1(3)	43535384	88	73	87	22	6	15	12	39	16	0	0.375	1.000	1.000
511	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(9), AR(5), ESR2(4), ESRRA(1), HNF4A(2), NR1D2(2), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(1), NR2F2(4), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(5), PPARD(1), PPARG(2), RARA(4), RARB(3), RARG(1), RORA(3), RORC(2), RXRB(4), RXRG(2), THRA(2), VDR(2)	40701245	77	73	76	26	10	13	16	27	11	0	0.612	1.000	1.000
512	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(3), ACTG2(1), ACTR2(2), AKT1(3), CDC42(1), CFL1(1), CFL2(1), FLNA(6), FLNC(10), FSCN1(4), FSCN2(1), FSCN3(2), GDI2(2), MYH2(9), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PFN2(1), RHO(1), ROCK1(5), ROCK2(4), WASF1(1), WASL(7)	45640517	89	73	89	30	8	20	5	31	25	0	0.756	1.000	1.000
513	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(8), MAPK14(1), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SYK(2), SYT1(1), VAV1(4)	37521064	82	72	79	26	9	11	9	27	26	0	0.792	1.000	1.000
514	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CKB(1), CKMT1B(1), CPS1(6), DAO(1), EPRS(5), GATM(2), GLUD2(7), GOT1(3), GOT2(2), LAP3(4), NOS1(10), NOS3(4), OAT(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), PARS2(3), PRODH(4), PYCR1(1), PYCR2(1), RARS(3), RARS2(2)	35757050	81	72	79	23	8	6	17	32	18	0	0.502	1.000	1.000
515	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BAD(1), CBL(3), CFLAR(1), CRKL(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(5), JAK1(7), JAK3(4), MAPK3(3), MYC(2), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(4), RPS6KB1(2), SHC1(4), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(3), SYK(2)	33198415	76	70	75	21	9	11	13	24	19	0	0.459	1.000	1.000
516	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAD(1), BAX(1), BCL2A1(2), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(3), IKBKE(3), LTA(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(8), PTPN13(9), RIPK1(1), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	43389187	78	69	77	20	5	14	15	30	14	0	0.312	1.000	1.000
517	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(4), CASP7(1), CASP8(1), CFLAR(1), DAXX(6), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MAP3K1(8), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(13), PTPN13(9), RB1(4), RIPK2(4), SPTAN1(12)	42361490	82	69	82	25	6	9	12	29	23	3	0.739	1.000	1.000
518	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(2), GNAS(5), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1)	33890354	77	69	74	23	11	8	6	29	23	0	0.749	1.000	1.000
519	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(2), GALNT1(1), GALNT10(7), GALNT11(4), GALNT13(3), GALNT14(3), GALNT2(3), GALNT4(1), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), OGT(5), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(6)	32403597	74	68	70	27	6	8	16	25	19	0	0.860	1.000	1.000
520	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	28	ACTR2(2), ARHGAP1(1), ARHGAP5(6), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(3), ARPC1B(2), BAIAP2(2), CFL1(1), DIAPH1(7), GSN(5), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PIP5K1B(1), PPP1R12B(2), ROCK1(5), SRC(4), TLN1(14), VCL(2)	43752436	75	68	74	16	3	9	9	28	26	0	0.319	1.000	1.000
521	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(4), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(2), GTF2H4(1), ILK(4), MNAT1(1), POLR1A(6), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(5), POLR2I(1), POLR2J(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(2), TAF7(2), TBP(1)	35228221	74	68	69	21	5	7	8	30	24	0	0.655	1.000	1.000
522	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(4), ALG14(1), ALG3(3), ALG5(2), ALG6(3), ALG8(2), ALG9(2), B4GALT1(1), B4GALT3(2), DOLPP1(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), RFT1(2), RPN1(3), RPN2(1), ST6GAL1(1), STT3B(4)	42113922	82	67	81	20	4	19	4	28	27	0	0.347	1.000	1.000
523	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(8), ACACB(5), ACADM(1), ACAT1(1), ACSS1(4), ACSS2(7), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(5), SUCLG2(2)	37903683	75	67	72	20	4	8	21	22	18	2	0.365	1.000	1.000
524	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), AKT1(3), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(2), ITPKB(2), ITPR1(7), ITPR2(13), ITPR3(5), MAPK3(3), NR1I3(1), PAK1(3), PDE3A(4), PDE3B(3), PI3(1), PIK3C2G(5), PIK3CD(2), PIK3R1(5)	46768437	74	66	74	25	8	12	8	33	13	0	0.737	1.000	1.000
525	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(2), EIF1(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), FLT1(10), FLT4(14), HIF1A(4), HRAS(1), KDR(6), NOS3(4), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PXN(3), SHC1(4)	31583049	75	66	74	26	12	7	10	24	21	1	0.876	1.000	1.000
526	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(2), ITPKB(2), MIOX(2), OCRL(3), PIK3C2A(6), PIK3C2B(6), PIK3C2G(5), PIK3CB(5), PIK3CG(4), PLCB1(4), PLCB2(4), PLCB3(3), PLCB4(7), PLCD1(3), PLCG1(4), PLCG2(4)	42879605	76	65	74	26	6	7	5	36	22	0	0.939	1.000	1.000
527	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MADD(9), MAP3K1(8), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(13), RB1(4), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	39344213	74	65	74	25	3	10	12	24	22	3	0.835	1.000	1.000
528	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SGMS1(1), SGPP1(2), SGPP2(2), SMPD1(6), SMPD2(3), SMPD4(2), SPHK1(2), SPHK2(1), SPTLC1(1), SPTLC2(2), UGT8(2)	34445146	74	64	70	25	13	13	7	25	16	0	0.635	1.000	1.000
529	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	43	AADAC(1), ABAT(1), ACADS(3), ACAT1(1), ACSM1(3), AKR1B10(3), ALDH1B1(4), ALDH3A2(3), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADH(1), HADHA(4), HMGCL(1), HMGCS1(2), HMGCS2(1), HSD17B4(2), ILVBL(3), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(3), PRDX6(2), RDH11(4), RDH13(1)	38742404	69	64	67	21	9	9	13	26	12	0	0.475	1.000	1.000
530	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(9), ATM(20), BRCA1(9), CDKN1A(3), CHEK1(1), CHEK2(2), JUN(2), MRE11A(3), NFKB1(2), NFKBIA(2), RAD50(4), RAD51(2), RBBP8(2), RELA(6), TP73(4)	28706811	71	62	67	21	8	9	7	28	17	2	0.725	1.000	1.000
531	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(3), B4GALT1(1), G6PC(3), GAA(3), GALE(2), GALK1(1), GALK2(2), GALT(3), GANC(3), GCK(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(7), MGAM(9), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH13(1), UGP2(1)	38163708	70	62	69	27	10	8	9	24	19	0	0.911	1.000	1.000
532	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(3), HDAC5(3), IGF1R(3), INS(1), INSR(6), MAP2K6(1), MAPK14(1), MAPK7(4), MEF2A(3), MEF2D(1), NFATC1(4), NFATC2(8), PIK3R1(5), PPP3CA(3), PPP3CC(3), SYT1(1)	31922538	68	61	62	19	11	7	5	24	21	0	0.576	1.000	1.000
533	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(1), ADCY3(7), ADCY9(7), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(4), ATP6V1D(1), ATP6V1G1(1), ERO1L(1), GNAS(5), PDIA4(1), PLCG1(4), PLCG2(4), PRKCA(2), SEC61B(2), TRIM23(5)	36995340	68	61	66	26	5	7	9	30	17	0	0.958	1.000	1.000
534	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GHR(1), GRB2(2), HRAS(1), INS(1), INSR(6), IRS1(5), JAK2(7), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(3), RAF1(4), SHC1(4), SLC2A4(3), SOS1(9), SRF(1), STAT5A(3), STAT5B(3)	28998261	67	59	63	19	6	8	12	24	17	0	0.655	1.000	1.000
535	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(3), MRPL13(1), MRPS7(2), RPL10A(2), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(2), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS7(1), RPS8(1), RPS9(1), RPSA(1)	22043805	63	59	63	17	5	6	11	26	14	1	0.570	1.000	1.000
536	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM2(1), CRKL(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(4), MAP3K1(8), MAPK14(1), MAPK3(3), PAK1(3), PLCG1(4), PRKCA(2), PTK2B(3), RAC1(1), RAF1(4), SHC1(4), SOS1(9), SRC(4), SYT1(1)	28336172	65	59	64	21	5	12	4	27	16	1	0.853	1.000	1.000
537	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	35	ACACA(8), ACAT1(1), ACYP1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1), PKM2(1)	34782934	67	59	66	19	4	7	13	21	21	1	0.574	1.000	1.000
538	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(3), ITGA1(8), ITGB1(7), ITGB3(3), PTK2(3), PXN(3), RAC1(1), SPTAN1(12), SRC(4), TLN1(14)	28528464	64	59	63	20	5	9	5	27	18	0	0.775	1.000	1.000
539	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(1), BAX(1), BID(2), BIRC2(3), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(3), IKBKG(1), JUN(2), MAP3K1(8), MAP3K14(2), MAPK10(2), MYC(2), NFKB1(2), NFKBIA(2), PARP1(5), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	35681958	65	58	62	28	2	14	11	19	18	1	0.981	1.000	1.000
540	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	38	AKR1B1(3), AKR1B10(3), ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(3), HK1(5), MPI(2), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(2), RDH11(4), RDH13(1), TPI1(2)	35875959	63	58	63	20	9	8	11	19	16	0	0.635	1.000	1.000
541	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(2), ELK1(1), FOS(1), IKBKB(3), IKBKG(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TLR10(3), TLR2(2), TLR3(1), TLR4(3), TLR6(2), TLR7(6), TLR9(1), TRAF6(2)	36225584	63	57	59	18	6	10	4	24	17	2	0.632	1.000	1.000
542	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(10), BAIAP2(2), CASP1(3), CASP7(1), CASP8(1), GAPDH(4), INS(1), INSR(6), MAGI1(5), MAGI2(6), RERE(10), WWP1(8), WWP2(4)	23569036	61	56	52	24	8	4	7	21	19	2	0.992	1.000	1.000
543	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(2), CDC42(1), CREB3(2), CREB5(3), DUSP10(1), EEF2K(4), EIF4E(2), ELK1(1), IL1R1(3), MAP2K3(4), MAP2K6(1), MAP3K10(4), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), SRF(1), TRAF6(2)	33387178	62	56	62	19	6	11	4	30	10	1	0.541	1.000	1.000
544	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(2), AKT1(3), ASAH1(3), GNAI1(2), GNB1(3), ITGAV(1), ITGB3(3), MAPK3(3), PDGFRA(8), PIK3R1(5), PLCB1(4), PRKCA(2), PTK2(3), RAC1(1), SMPD1(6), SMPD2(3), SPHK1(2), SRC(4)	25133053	58	55	57	21	8	11	4	23	12	0	0.816	1.000	1.000
545	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(4), CPOX(6), EPRS(5), FECH(2), GUSB(7), HCCS(1), HMOX1(3), HMOX2(1), PPOX(2), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4), UROD(2)	27378863	60	55	54	18	5	5	12	21	17	0	0.684	1.000	1.000
546	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(3), ATM(20), BAD(1), BAX(1), BID(2), CASP7(1), CASP9(2), PRKCA(2), PTK2(3), PXN(3), STAT1(6), TLN1(14)	26635246	61	54	60	17	6	7	7	24	17	0	0.576	1.000	1.000
547	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(2), AKT1(3), CAMK2A(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(5), GRB2(2), HRAS(1), MAPK14(1), MAPK3(3), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAC1(1), RPS6KA5(2), SOS1(9)	25240236	56	54	56	16	6	8	3	29	10	0	0.641	1.000	1.000
548	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(9), AXIN1(5), CTNNB1(2), DVL1(1), FZD1(4), GNAI1(2), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(2), PIK3R1(5), PPP2CA(1), RELA(6), TLR4(3), WNT1(2)	27878814	56	54	51	18	5	7	5	21	17	1	0.768	1.000	1.000
549	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(3), BID(2), BIRC2(3), BIRC3(5), CASP10(4), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFA(1), DFFB(1), GAS2(4), MAP3K14(2), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TRADD(2), TRAF2(1)	32754440	60	53	57	18	3	9	10	20	17	1	0.693	1.000	1.000
550	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), F2RL3(1), GNAI1(2), GNB1(3), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), PLA2G4A(2), PLCB1(4), PRKCA(2), PTGS1(2), PTK2(3), RAF1(4), SRC(4), SYK(2), TBXAS1(4)	24358796	58	53	57	18	6	8	9	18	16	1	0.686	1.000	1.000
551	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(1), DLG4(2), EPHB2(2), F2(4), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(4), MAPK7(4), MYEF2(1), PLD1(3), PLD2(7), PLD3(3), PTK2(3), RAF1(4), SRC(4), TEC(6), VAV1(4)	25929953	58	53	54	16	7	7	8	24	12	0	0.491	1.000	1.000
552	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(2), BLNK(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(8), MAPK3(3), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA3(3), SHC1(4), SOS1(9), SYK(2), VAV1(4), VAV2(4), VAV3(1)	30115663	58	52	58	17	5	11	7	23	12	0	0.478	1.000	1.000
553	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(10), EP300(16), FYN(2), IL7R(1), JAK1(7), JAK3(4), LCK(1), PIK3R1(5), PTK2B(3), STAT5A(3), STAT5B(3)	25759416	55	51	51	17	4	7	10	17	17	0	0.762	1.000	1.000
554	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(2), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), NOS1(10), PPP3CA(3), PPP3CC(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), SYT1(1)	25363665	56	51	55	20	10	9	4	24	9	0	0.713	1.000	1.000
555	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(10), EP300(16), NCOA3(8), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RARA(4)	20453810	52	50	49	18	3	4	8	23	14	0	0.773	1.000	1.000
556	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(1), G6PC(3), GAA(3), GALE(2), GALK1(1), GALK2(2), GALT(3), GCK(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(7), MGAM(9), PFKM(3), PFKP(3), PGM1(1)	32229810	55	50	54	24	7	6	6	18	18	0	0.978	1.000	1.000
557	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(6), DARS(3), EPRS(5), HARS(1), IARS(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(4), QARS(1), RARS(3), SARS(3), TARS(6), WARS(1), WARS2(4), YARS(1)	32235504	58	49	53	16	1	6	8	26	17	0	0.685	1.000	1.000
558	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM2(1), CAPN2(4), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(8), PPP3CA(3), PPP3CC(3), PRKCA(2), SYT1(1)	23801443	56	49	51	19	8	4	4	21	19	0	0.884	1.000	1.000
559	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(3), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(5), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(5), MAPK14(1), MAPK3(3), MKNK1(2), PDK2(3), PIK3R1(5), PRKCA(2), RPS6KB1(2)	23636160	51	48	51	18	6	8	6	21	10	0	0.797	1.000	1.000
560	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2F1(1), NCOA1(4), NCOA2(11), NCOA3(8), NCOR2(7), POLR2A(13), RARA(4), TBP(1)	24972585	58	48	51	29	6	6	8	17	21	0	0.985	1.000	1.000
561	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(6), CXCR4(1), GNAI1(2), GNB1(3), HRAS(1), MAPK3(3), NFKB1(2), PIK3C2G(5), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PTK2B(3), PXN(3), RAF1(4), RELA(6)	25800150	53	46	49	24	4	8	5	20	14	2	0.993	1.000	1.000
562	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(1), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SMPD1(6), SMPD2(3), SPTLC1(1), SPTLC2(2)	23445985	51	46	50	18	9	7	4	20	11	0	0.739	1.000	1.000
563	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(3), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(7), GSK3A(3), GSK3B(3), LYN(1), PFKL(3), PFKM(3), PFKP(3), PLCG1(4), PRKCE(4), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(2), VAV2(4)	25044969	51	46	48	18	3	7	10	18	13	0	0.843	1.000	1.000
564	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), IKBKG(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK5(1), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2)	30930118	50	46	50	14	10	6	4	21	9	0	0.457	1.000	1.000
565	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(2), CFL1(1), GNAS(5), GNB1(3), HRAS(1), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(5), PLCB1(4), PPP1R12B(2), PRKCA(2), PTK2(3), RAF1(4), ROCK2(4)	24333289	47	44	45	13	4	6	7	20	10	0	0.690	1.000	1.000
566	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), ASAH1(3), CAMP(1), CERK(6), CREB3(2), CREB5(3), DAG1(3), EPHB2(2), FOS(1), ITPKA(2), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2)	27735983	48	44	45	16	8	4	8	14	14	0	0.801	1.000	1.000
567	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(9), COL4A6(7), P4HB(2), SLC23A1(7), SLC23A2(2), SLC2A1(2), SLC2A3(2)	25533935	47	44	47	18	4	12	5	17	8	1	0.733	1.000	1.000
568	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRB2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), DRD1(1), DRD2(1), DRD3(3), DRD5(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2)	24622013	48	43	46	25	8	4	3	23	10	0	0.971	1.000	1.000
569	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(2), CASP2(1), CHUK(2), IKBKB(3), IKBKG(1), JUN(2), LTA(1), MAP2K3(4), MAP2K6(1), MAP3K1(8), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	24269862	46	43	43	15	4	6	2	19	14	1	0.906	1.000	1.000
570	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(1), ARSD(3), ARSE(2), CYP11B1(3), CYP11B2(2), HSD11B2(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(3), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A8(2), UGT1A9(5), UGT2B15(1), UGT2B4(4)	27033091	46	42	46	14	4	3	11	12	16	0	0.535	1.000	1.000
571	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(6), CSK(4), CTNNA1(7), CTNNA2(8), CTNNB1(2), PTK2(3), PXN(3), SRC(4), VCL(2)	19060330	44	42	44	17	8	6	6	17	6	1	0.826	1.000	1.000
572	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(8), DDX20(7), E2F1(1), ETS1(2), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(7), RBL2(5), SIN3A(4), SIN3B(3)	26135928	45	42	45	13	7	5	4	17	12	0	0.545	1.000	1.000
573	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	23	ASNS(2), CA1(1), CA13(2), CA14(3), CA5B(2), CA6(1), CA7(1), CA9(2), CPS1(6), CTH(2), GLS(7), GLS2(4), GLUD2(7), GLUL(2), HAL(1)	20492192	43	42	41	15	2	6	6	25	4	0	0.799	1.000	1.000
574	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(2), IKBKB(3), IKBKG(1), IL1R1(3), IRAK1(3), MAP3K1(8), MAP3K14(2), MAP3K7(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2)	24297343	48	42	45	15	5	11	3	11	16	2	0.706	1.000	1.000
575	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(2), ARHGEF1(2), F2(4), F2R(2), F2RL3(1), GNA12(1), GNA13(4), GNAI1(2), GNB1(3), MAP3K7(3), PIK3R1(5), PLCB1(4), PPP1R12B(2), PRKCA(2), PTK2B(3), ROCK1(5)	23428080	45	42	45	13	8	5	3	18	10	1	0.559	1.000	1.000
576	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(2), CD33(2), CD5(1), IFNA1(2), IFNB1(3), IL3(1), IL4(1), ITGAX(8), TLR2(2), TLR4(3), TLR7(6), TLR9(1)	18230793	42	40	41	14	5	6	11	14	6	0	0.575	1.000	1.000
577	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(3), ANXA4(3), ANXA6(3), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B2(1), PLA2G4A(2), PTGDR(2), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), PTGS1(2), PTGS2(5), TBXAS1(4)	20337800	42	40	42	20	5	4	8	15	9	1	0.953	1.000	1.000
578	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(2), AKT1(3), BAD(1), BAX(1), CSF2RB(5), IGF1R(3), IL3(1), KIT(3), KITLG(2), PIK3R1(5), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	19485402	40	39	40	18	8	2	2	21	7	0	0.932	1.000	1.000
579	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	23	AKR1B1(3), ALDOA(3), ALDOB(3), ALDOC(1), FBP1(1), FPGT(1), GCK(2), GMDS(2), GMPPA(2), GMPPB(3), HK1(5), MPI(2), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(2), TPI1(2)	22620851	43	39	43	18	4	4	8	12	15	0	0.957	1.000	1.000
580	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(3), BIRC3(5), CASP8(1), CFLAR(1), IKBKG(1), JUN(2), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	26674377	42	39	42	15	4	8	7	18	4	1	0.658	1.000	1.000
581	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT6(1), AGPS(5), CHPT1(3), ENPP2(3), ENPP6(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(7), PPAP2B(1), PPAP2C(3)	23345073	42	38	39	18	7	4	5	17	9	0	0.894	1.000	1.000
582	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	11	ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(8), CLTA(1), CLTB(2), COPA(6), GBF1(13), GPLD1(2), KDELR2(2)	15853316	38	37	38	13	1	2	5	19	10	1	0.908	1.000	1.000
583	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX5(4), CYP1A2(4), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), RDH11(4), RDH13(1)	23945609	39	37	38	16	6	3	4	18	8	0	0.824	1.000	1.000
584	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(2), NFKBIA(2), RB1(4), RELA(6), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(4), WT1(3)	17377959	40	37	37	15	2	5	3	14	13	3	0.975	1.000	1.000
585	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), DPM2(1), GRB2(2), HRAS(1), KLK2(1), NTRK1(8), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(4), SOS1(9)	13238470	40	37	38	13	3	7	3	18	9	0	0.781	1.000	1.000
586	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	25	ACAA1(3), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH3A2(3), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), SOAT2(4), SRD5A1(1)	21292634	39	36	38	13	4	1	5	21	8	0	0.836	1.000	1.000
587	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), BAD(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), MAPK3(3), PIK3R1(5), RAF1(4), SHC1(4), SOS1(9)	16298899	40	36	40	13	7	6	4	16	7	0	0.606	1.000	1.000
588	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(7), GALNT2(3), GALNT4(1), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(6)	14590676	38	36	35	22	3	2	7	12	14	0	0.998	1.000	1.000
589	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(3), GRB2(2), HRAS(1), MAPK3(3), MAPK7(4), MEF2A(3), MEF2D(1), NTRK1(8), PIK3R1(5), PLCG1(4), SHC1(4)	15350205	38	35	35	12	5	4	4	18	7	0	0.751	1.000	1.000
590	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(3), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(2), VNN1(1)	17126387	36	34	36	12	3	4	5	14	10	0	0.769	1.000	1.000
591	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(1), CA14(3), CA5B(2), CA6(1), CA7(1), CA9(2), CPS1(6), CTH(2), GLS(7), GLS2(4), GLUL(2), HAL(1)	18914320	34	33	34	11	1	5	4	20	4	0	0.747	1.000	1.000
592	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(2), ASPH(3), COPS5(1), EP300(16), HIF1A(4), JUN(2), NOS3(4), P4HB(2)	16599924	34	32	31	12	1	0	5	13	13	2	0.915	1.000	1.000
593	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(4), ILVBL(3), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(4), VARS2(6)	17577080	36	32	36	11	2	7	6	12	9	0	0.531	1.000	1.000
594	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(3), PNPLA3(3), SH3GLB1(3)	24325921	34	32	33	10	2	4	4	18	6	0	0.706	1.000	1.000
595	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(5), CASP1(3), CASP10(4), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNB1(3), LMNB2(1), PRF1(1)	19078382	34	31	34	12	0	8	7	12	7	0	0.765	1.000	1.000
596	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(5), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(5), PRKACG(3), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	15890797	31	31	31	12	4	0	0	17	10	0	0.860	1.000	1.000
597	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(5), HEXA(4), LCT(7), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	16040691	34	31	34	12	5	6	2	13	8	0	0.671	1.000	1.000
598	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(3), IGF1R(3), INPPL1(4), PDK2(3), PIK3R1(5), PPP2CA(1), RPS6KB1(2)	16706000	33	31	31	10	4	4	2	11	12	0	0.670	1.000	1.000
599	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(10), EP300(16), MAPK3(3), PELP1(1), SRC(4)	14702121	34	31	31	15	2	6	6	10	10	0	0.906	1.000	1.000
600	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(7), JAK2(7), JAK3(4), MAPK3(3), STAT3(3), TYK2(7)	11689003	31	31	30	10	2	0	8	12	9	0	0.848	1.000	1.000
601	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(2), PSMD11(4), PSMD12(1), PSMD13(2), PSMD2(5), PSMD6(2)	16157887	33	30	32	11	3	3	4	8	15	0	0.833	1.000	1.000
602	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), NPAS2(1), PER1(6), PER2(6), PER3(6)	16900305	30	30	28	13	4	2	7	10	6	1	0.904	1.000	1.000
603	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(5), FASN(9), MCAT(2), OLAH(2), OXSM(3)	15626713	29	29	29	10	3	7	5	10	4	0	0.543	1.000	1.000
604	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), EIF4E(2), FBL(1), GPT(4), LDHB(2), LDHC(3), MAPK14(1), NCL(6)	8935488	29	27	28	10	0	1	11	9	8	0	0.859	1.000	1.000
605	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(1), BNIP1(1), GOSR1(1), SEC22B(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(1), STX19(1), STX2(2), STX4(2), STX5(1), STX7(2), STX8(1), TSNARE1(3), USE1(1), VAMP1(1), VAMP2(1), VTI1A(1)	16806685	28	26	28	11	4	4	4	13	3	0	0.706	1.000	1.000
606	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(2), GABRA2(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(6), SRC(4), UBQLN1(3)	12058520	26	25	26	12	2	5	6	10	2	1	0.892	1.000	1.000
607	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(5), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(2)	8054820	22	22	20	10	2	2	3	10	5	0	0.912	1.000	1.000
608	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	8	HK1(5), LCT(7), MPI(2), PGM1(1), PYGL(2), PYGM(4), TPI1(2)	12854217	23	22	23	10	7	1	4	8	3	0	0.796	1.000	1.000
609	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(5), CPOX(6), FECH(2), PPOX(2), UROD(2)	7692088	22	22	17	10	1	1	3	7	10	0	0.962	1.000	1.000
610	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST12(2), CHST14(1), CHST3(2), CHST7(2), DSE(1), UST(1), XYLT1(5), XYLT2(2)	11335976	22	22	22	10	5	6	0	7	4	0	0.713	1.000	1.000
611	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(5), PLCB1(4), PLCG1(4), PRKCA(2), VAV1(4)	10730507	22	21	21	11	3	3	2	8	6	0	0.962	1.000	1.000
612	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR2(4), ITPKA(2), PDE1A(1), PDE1B(5), PLCB1(4), PLCB2(4)	10564147	20	20	20	10	6	2	0	7	5	0	0.927	1.000	1.000
613	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(3), CAT(2), GHR(1), HRAS(1), IGF1R(3), PIK3R1(5), SHC1(4)	10825227	19	17	19	10	3	2	1	9	4	0	0.971	1.000	1.000
614	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(4), PRKCA(2), PTK2B(3), SYT1(1)	13655108	18	16	17	11	2	4	2	6	4	0	0.984	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(2)	2083524	5	5	5	3	0	2	1	2	0	0	0.875	1.000	1.000
616	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	1622802	2	2	2	3	0	0	2	0	0	0	0.974	1.000	1.000
