rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(3)	1546684	7	7	7	0	3	2	0	1	1	0	0.127	0.00286	1.000
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), MDM2(3), PRB1(1)	5771295	22	17	22	3	5	1	4	4	8	0	0.0867	0.00339	1.000
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCND1(4), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(3), CDKN2A(4), E2F1(1), E2F2(1), PRB1(1)	6796377	20	16	20	0	4	1	5	2	8	0	0.00260	0.00967	1.000
4	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(3), TYR(4)	7393124	18	15	18	1	6	2	3	5	2	0	0.0278	0.0174	1.000
5	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), RB1(6), SKP2(3)	6521310	17	14	17	1	2	3	4	1	7	0	0.0676	0.0234	1.000
6	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(3), HGD(5)	1697424	10	6	10	2	4	0	1	2	3	0	0.309	0.0306	1.000
7	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), E2F1(1), RB1(6), RBL1(4)	12244687	36	25	36	4	7	3	8	5	13	0	0.0196	0.0429	1.000
8	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), FBXW7(5), RB1(6)	6310719	17	13	17	1	4	3	2	2	6	0	0.0601	0.0451	1.000
9	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(1), CDKN1B(3), CUL1(1), E2F1(1), RB1(6), RBX1(1), SKP2(3), UBE2M(1)	6533825	18	15	18	2	1	4	4	1	8	0	0.139	0.0453	1.000
10	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(3), MTMR1(4), MTMR2(3), MTMR6(1), TYR(4)	11461538	26	20	26	2	6	4	5	7	4	0	0.0176	0.0500	1.000
11	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(5), ALPPL2(2), DHFR(1), FPGS(2), GGH(1), SPR(1)	4957773	13	12	13	2	5	2	3	1	2	0	0.161	0.0705	1.000
12	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFB11(1)	3060056	9	7	9	0	1	4	0	2	2	0	0.0791	0.0792	1.000
13	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), ENPP1(4), ENPP3(2), NADSYN1(4), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(5), NT5C(3), NT5E(1), NT5M(1)	11099026	28	18	28	2	4	10	4	7	3	0	0.00317	0.0977	1.000
14	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), RB1(6), SP3(4)	5084809	11	9	11	1	1	0	2	1	7	0	0.413	0.116	1.000
15	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(3), ATM(8), BAX(1), BCL2(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), E2F1(1), MDM2(3), RB1(6), TIMP3(1)	13210305	32	20	32	5	5	3	6	10	8	0	0.134	0.144	1.000
16	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), CYP2A7(1), NAT1(1), NAT2(3), XDH(8)	6079271	16	11	16	1	4	3	1	6	2	0	0.0312	0.158	1.000
17	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IL12B(2), IL18(3)	2273114	9	5	9	2	2	1	1	5	0	0	0.469	0.158	1.000
18	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), CAT(3), GH1(1), GHR(4), IGF1(1), IGF1R(7), SHC1(1), SOD2(1)	7273567	19	13	19	1	4	3	4	5	3	0	0.00940	0.158	1.000
19	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(11)	6433347	12	10	12	1	2	2	3	4	1	0	0.0803	0.191	1.000
20	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	7701930	20	11	20	3	4	3	4	6	3	0	0.123	0.218	1.000
21	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(1), CSF1R(4), EGF(7), MET(10), PDGFRA(18), PRKCA(5), SH3GLB1(3), SH3KBP1(5)	12787234	53	28	51	12	13	10	6	14	9	1	0.0806	0.219	1.000
22	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL1B(2), IL5(1), IL5RA(2), IL6(1)	4080134	14	9	14	2	2	4	0	7	1	0	0.115	0.228	1.000
23	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(2), HK1(4), PFKL(4), PGK1(2), PKLR(3), TPI1(1)	7067262	19	12	19	0	7	7	0	1	4	0	0.000165	0.233	1.000
24	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5)	1614982	5	4	5	0	2	1	0	2	0	0	0.207	0.248	1.000
25	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(7), ZAP70(5)	6907169	20	13	20	4	5	5	1	8	1	0	0.195	0.262	1.000
26	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(7), ERBB3(4), NRG1(3)	5851263	14	10	14	2	7	2	0	1	4	0	0.196	0.272	1.000
27	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), PANK2(1), PANK4(3)	10605104	21	16	20	4	4	5	0	7	5	0	0.303	0.285	1.000
28	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(5), PDHA1(5), PDHA2(4)	5311617	16	11	15	4	2	7	1	3	3	0	0.162	0.290	1.000
29	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	2417614	5	4	5	0	0	0	3	0	2	0	0.337	0.297	1.000
30	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), GGPS1(1), IDI1(2), SQLE(1)	3243017	6	5	6	0	0	0	4	0	2	0	0.227	0.300	1.000
31	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(5), PANK2(1), PANK4(3), VNN1(2)	13159542	28	21	27	4	6	6	1	9	6	0	0.0909	0.301	1.000
32	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(1), BCL2(1), IGF1R(7), POLR2A(7), PPP2CA(4), PRKCA(5), RB1(6), TEP1(8), TERF1(1), TERT(2), TNKS(1), XRCC5(3)	18852435	46	28	46	7	16	2	8	12	7	1	0.0131	0.306	1.000
33	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1)	1812037	6	4	6	1	1	1	0	3	1	0	0.359	0.317	1.000
34	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(4), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(5), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1)	16405697	37	22	37	6	7	12	5	8	5	0	0.0203	0.318	1.000
35	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCL5(1), CCR3(1), HLA-DRA(3), HLA-DRB1(1), IL3(1), IL5(1)	2322073	10	6	10	3	2	2	0	4	2	0	0.491	0.322	1.000
36	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(5), DBH(3), DDC(2), GAD1(2), GAD2(1), HDC(2), MAOA(2), PAH(2), TH(3), TPH1(3)	10957299	28	17	28	6	11	8	0	6	3	0	0.0496	0.327	1.000
37	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4)	6029315	22	16	22	6	5	5	2	7	3	0	0.299	0.334	1.000
38	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), HTR2C(3), PLCB1(3), TUB(4)	5455663	12	9	12	3	4	2	0	5	1	0	0.371	0.354	1.000
39	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), LPO(5), MPO(2), PRDX1(1), TPO(6), TYR(4)	7359075	23	13	23	5	9	7	1	5	0	1	0.0660	0.363	1.000
40	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(5), AMY2B(3), ENPP1(4), ENPP3(2), GAA(5), GANAB(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), MGAM(9), PGM3(1), PYGB(1), PYGL(5), PYGM(1), SI(9), UCHL3(1), UGDH(1), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4), UXS1(2)	42840683	97	60	96	15	31	19	14	22	11	0	0.000104	0.397	1.000
41	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(2), ELK1(3), FOS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(4), JAK3(3), MAPK3(1), PTPN11(7), RAF1(1), SHC1(1), SOS1(4), SRF(2), STAT3(2)	18217559	38	25	36	7	6	8	2	14	7	1	0.0611	0.407	1.000
42	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(2), HBEGF(1), IFRD1(2), IL18(3), IL1R1(2), NR4A3(1), WDR1(1)	8196234	16	12	16	2	5	1	2	4	4	0	0.161	0.417	1.000
43	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL10(1), IL12B(2), IL15(2), IL16(8), IL18(3), IL3(1), IL5(1), IL6(1), IL9(1), TNF(1)	7573570	22	15	22	5	3	2	4	9	4	0	0.329	0.421	1.000
44	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), CSAD(1), GAD1(2), GAD2(1), GGT1(2)	4384590	8	6	8	0	2	2	2	2	0	0	0.0599	0.428	1.000
45	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	1258225	5	2	5	0	0	3	0	2	0	0	0.195	0.431	1.000
46	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(2), ARHGDIB(1), CASP1(4), CASP10(1), CASP8(2), CYCS(2), GZMB(1), PRF1(3)	9820796	19	13	19	4	5	5	2	7	0	0	0.219	0.436	1.000
47	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(2), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(2)	6807778	15	9	15	3	3	4	1	4	3	0	0.240	0.438	1.000
48	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(8), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(7), RB1(6), WEE1(1), YWHAH(1)	12802231	30	18	30	6	4	2	4	4	16	0	0.469	0.441	1.000
49	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(5), SP3(4), WT1(1)	4752492	10	7	8	0	4	1	1	3	1	0	0.0433	0.443	1.000
50	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(3), MYL2(2), MYLK(5), NCF2(3), PAK1(2), PDGFRA(18), PLD1(7), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(5), VAV1(5), WASF1(1)	23734567	63	35	61	10	14	11	10	15	13	0	0.00466	0.446	1.000
51	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(4), COL4A4(4), COL4A5(8), COL4A6(6), F10(1), F12(1), F2(3), F2R(2), F5(7), F8(18), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), PROS1(1), SERPINC1(1), SERPING1(3)	33846408	77	49	77	16	20	13	13	19	11	1	0.00743	0.447	1.000
52	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT2(2), ST3GAL3(2), ST3GAL4(3)	5498489	15	10	15	4	7	0	1	5	2	0	0.397	0.463	1.000
53	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(6), CREB1(1), CREB3(3), MAPK1(2), RAF1(1), SNX13(1), TERF2IP(1)	8503172	17	12	16	2	1	0	4	6	6	0	0.169	0.464	1.000
54	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP8(2), CFL1(1), CFLAR(1)	2960244	5	4	5	0	0	1	1	2	1	0	0.194	0.469	1.000
55	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(3), GLS(2), GLUD1(4), GOT1(2)	5952610	13	7	13	2	2	1	0	5	5	0	0.415	0.476	1.000
56	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), GAD1(2), HDC(2), TH(3), TPH1(3)	4587198	13	8	13	2	7	3	0	2	1	0	0.0691	0.476	1.000
57	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	1387798	3	3	3	1	2	0	0	1	0	0	0.732	0.494	1.000
58	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PDXK(1), PSAT1(2)	3702602	8	6	8	3	3	3	0	2	0	0	0.560	0.504	1.000
59	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(1), ALAS2(1), CPO(2), FECH(1), HBA2(1), HBB(1), UROD(1), UROS(1)	5987987	11	7	11	2	4	2	1	3	1	0	0.215	0.514	1.000
60	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(2), TAT(1), TYR(4)	3592854	9	6	9	3	4	0	1	4	0	0	0.679	0.527	1.000
61	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(2), ELK1(3), FOS(1), IGF1(1), IGF1R(7), IRS1(4), MAPK3(1), MAPK8(2), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2)	16047763	40	30	38	9	8	9	5	10	7	1	0.0743	0.529	1.000
62	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(4), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2)	4887224	13	6	13	2	1	3	2	5	2	0	0.308	0.530	1.000
63	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7)	8009960	17	10	17	2	5	0	3	5	4	0	0.103	0.536	1.000
64	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7)	8009960	17	10	17	2	5	0	3	5	4	0	0.103	0.536	1.000
65	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(3), UCHL3(1), UGDH(1), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4)	13413175	27	19	26	5	7	3	6	10	1	0	0.0806	0.547	1.000
66	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(2), GFPT1(4), GNPDA1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), PGM3(1), RENBP(3), UAP1(2)	12926250	28	19	28	4	8	7	4	6	3	0	0.0273	0.567	1.000
67	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(3), EPRS(3), FECH(1), GUSB(3), HCCS(4), PPOX(1), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4), UROD(1), UROS(1)	20873622	43	29	42	8	11	5	11	15	1	0	0.0370	0.570	1.000
68	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(8), ATR(6), CCNA1(2), CCND1(4), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), DHFR(1), E2F1(1), RB1(6), SKP2(3), TGFB2(2), TGFB3(1)	22414600	50	28	50	7	10	6	8	10	16	0	0.0176	0.571	1.000
69	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(1), IDS(2), LCT(10), NAGLU(3), SPAM1(3)	15626810	36	22	36	6	16	2	6	6	6	0	0.0400	0.575	1.000
70	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), NR1H3(5), RXRA(1)	4151467	7	6	6	2	3	2	2	0	0	0	0.339	0.577	1.000
71	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC3(1), PAK1(2), PDGFRA(18), RAC1(1), WASL(2)	7344668	30	15	28	7	0	9	2	11	8	0	0.349	0.580	1.000
72	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	6001895	14	13	14	4	5	2	3	2	2	0	0.439	0.591	1.000
73	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), MBTPS1(2), MBTPS2(3), SCAP(2), SREBF1(6), SREBF2(3)	9136512	18	12	18	4	4	3	3	5	3	0	0.235	0.599	1.000
74	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(2), FUCA2(4), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2C1(2), MANBA(1), NEU1(1), NEU2(5), NEU3(2)	12590038	32	24	32	7	8	3	7	9	5	0	0.205	0.600	1.000
75	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), BCMO1(1), RDH5(1)	2977776	3	3	3	1	0	3	0	0	0	0	0.540	0.600	1.000
76	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(3), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(1)	8897673	18	10	18	1	6	4	2	3	3	0	0.00792	0.602	1.000
77	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF2S2(1), EIF4E(2), IGF1(1), IGF1R(7), INPPL1(5), PPP2CA(4), RPS6KB1(2)	11488448	23	13	23	3	5	3	5	7	3	0	0.0444	0.605	1.000
78	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT5(3), FUT6(2), ST3GAL3(2)	3878740	9	6	9	3	6	1	0	1	1	0	0.562	0.616	1.000
79	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(9), DFFA(2), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1)	8065853	20	12	20	3	9	1	2	5	3	0	0.117	0.619	1.000
80	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(2), SHMT1(2)	3177317	5	4	5	1	2	1	2	0	0	0	0.351	0.622	1.000
81	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(3)	11432026	27	13	26	5	7	4	6	6	4	0	0.0734	0.635	1.000
82	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL10(1)	3033626	7	5	7	3	1	1	1	3	1	0	0.637	0.642	1.000
83	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(2), AKT1(1), BAX(1), BCL2(1), CSF2RB(2), IGF1(1), IGF1R(7), IL3(1), IL3RA(2), KIT(6), KITLG(2), PRKACG(1), PRKAR1A(2), YWHAH(1)	13850534	30	20	30	6	7	1	7	9	6	0	0.116	0.643	1.000
84	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	2346946	5	3	5	2	1	1	0	2	1	0	0.649	0.647	1.000
85	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(4), FOS(1), FYN(1), THBS1(4)	5643849	10	7	10	3	3	4	2	0	1	0	0.295	0.652	1.000
86	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(1), PC(2), PDHA1(5), SLC25A1(1)	7069209	12	11	11	3	1	3	0	4	4	0	0.361	0.658	1.000
87	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CMAS(2), GFPT1(4), GFPT2(3), GNPDA1(2), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), MTMR1(4), MTMR2(3), MTMR6(1), NANS(1), PGM3(1), RENBP(3), UAP1(2)	21873426	43	29	43	7	9	10	7	10	7	0	0.0234	0.659	1.000
88	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3D(1), CD86(1), CTLA4(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1), PTPN11(7)	6884876	18	15	16	5	2	4	2	8	2	0	0.420	0.662	1.000
89	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(1), AGPAT6(1), AGPS(3), ENPP2(4), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PPAP2A(2), PPAP2C(1)	17651031	41	23	41	7	8	6	8	14	5	0	0.0369	0.662	1.000
90	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(3), EGF(7), HGS(3), TF(2), TFRC(2)	7784932	17	12	17	5	6	3	2	4	2	0	0.390	0.685	1.000
91	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	2007314	3	2	3	1	1	0	1	1	0	0	0.729	0.697	1.000
92	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F12(1), F13B(4), F2(3), F5(7), F7(2), F8(18), F9(3), FGA(6), FGB(1), FGG(1), LPA(7), PLAT(1), PLAU(1), PLG(4), SERPINB2(2), SERPINE1(2), SERPINF2(1), VWF(7)	26922907	72	40	72	17	18	11	10	20	13	0	0.0381	0.699	1.000
93	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(2), SDHA(4), SDHC(2), UQCRC1(3)	5041064	11	7	10	2	2	2	4	3	0	0	0.228	0.699	1.000
94	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), PTGS1(2), PTGS2(2)	4079876	7	6	7	2	4	0	0	2	1	0	0.690	0.700	1.000
95	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), E2F1(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PAK1(2), RAC1(1), RAF1(1), RB1(6), RELA(1)	12533571	30	19	30	6	6	1	5	3	14	1	0.200	0.701	1.000
96	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), LCT(10), MPI(1), PYGL(5), PYGM(1), TPI1(1), TREH(1)	10224406	23	13	23	4	5	4	4	4	6	0	0.0535	0.704	1.000
97	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(1), TPI1(1)	2987206	7	3	7	0	0	4	0	2	1	0	0.101	0.705	1.000
98	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(5), ACO2(4), FH(1)	5544233	10	6	10	0	3	2	2	2	1	0	0.0346	0.710	1.000
99	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(1), GALNT2(2), GALNT3(1), GALNT6(3), GALNT8(1), GALNT9(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), WBSCR17(5)	11013829	25	16	25	5	10	4	3	6	2	0	0.111	0.713	1.000
100	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(2), BAX(1), BCL2(1), BIRC2(2), CASP8(2), CYCS(2), DFFA(2), DIABLO(2)	10226683	17	11	17	3	5	4	2	5	1	0	0.140	0.718	1.000
101	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM3(1), CDKN1A(1), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(5), SP3(4), SYT1(1)	16012806	34	22	33	8	9	4	5	10	5	1	0.155	0.723	1.000
102	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(4)	2482127	6	6	6	3	2	1	1	1	1	0	0.706	0.725	1.000
103	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(3)	10700515	23	11	23	5	4	4	5	6	4	0	0.168	0.725	1.000
104	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(5)	3758369	8	5	8	3	3	0	1	3	0	1	0.602	0.730	1.000
105	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(4), JAK3(3), MAPK1(2), MAPK3(1), STAT3(2), TYK2(7)	8962076	20	10	20	3	6	0	2	6	5	1	0.164	0.731	1.000
106	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	868472	1	1	1	1	0	1	0	0	0	0	0.898	0.732	1.000
107	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), BCAR1(3), CDKN1B(3), ILK(1), ITGB1(2), MAPK1(2), MAPK3(1), PTK2(2), SHC1(1), SOS1(4)	11210369	20	12	20	3	5	1	3	4	6	1	0.167	0.739	1.000
108	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25A(1), CDC25B(1), CHEK1(3), MYT1(7), WEE1(1), YWHAH(1)	10510208	22	13	22	6	3	2	2	4	11	0	0.688	0.740	1.000
109	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(5), LPO(5), MPO(2), MTHFR(6), SHMT1(2), TPO(6)	8843261	30	13	30	7	11	9	3	5	2	0	0.0541	0.740	1.000
110	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	IL1B(2), MST1(6), MST1R(2), TNF(1)	4993252	11	6	10	3	4	6	0	1	0	0	0.223	0.744	1.000
111	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(2), GLUD1(4), OAT(1)	4198168	9	6	9	3	2	1	0	4	2	0	0.636	0.751	1.000
112	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(4), CYP11B1(2), CYP11B2(1), HSD3B1(2), HSD3B2(1)	7039220	11	10	11	3	4	0	2	2	3	0	0.365	0.754	1.000
113	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11A1(4), CYP11B1(2), CYP11B2(1), HSD3B1(2), HSD3B2(1)	7039220	11	10	11	3	4	0	2	2	3	0	0.365	0.754	1.000
114	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(2)	2914616	4	3	4	1	0	1	2	0	1	0	0.624	0.762	1.000
115	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP3A4(3), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(2), PON3(1)	13713969	25	21	24	5	12	1	2	4	6	0	0.119	0.765	1.000
116	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL5(1), MAF(3), MAP2K3(3), NFATC1(2), NFATC2(5), PRKACG(1), PRKAR1A(2)	9304757	20	13	20	6	8	1	3	7	1	0	0.311	0.774	1.000
117	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(2), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(7)	8277078	16	9	16	3	4	1	1	7	2	1	0.283	0.781	1.000
118	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(5), AGT(2), AGTR2(3), ANPEP(3), CMA1(2), CTSA(1), CTSG(2), ENPEP(6), LNPEP(1), MME(2), NLN(1), REN(2), THOP1(5)	16156609	39	25	38	10	11	6	6	10	6	0	0.169	0.786	1.000
119	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2), SHMT1(2)	4188970	4	4	4	1	1	1	2	0	0	0	0.463	0.787	1.000
120	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CBS(4), CTH(1), MUT(1)	3745831	10	4	10	0	2	5	0	2	1	0	0.0264	0.789	1.000
121	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(1), ALAS2(1), FECH(1), PPOX(1), UROD(1), UROS(1)	5773801	8	5	8	1	2	2	1	3	0	0	0.243	0.790	1.000
122	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(4), HK2(3), HK3(3), PGM3(1), TGDS(1)	7788788	14	9	14	2	6	4	2	1	1	0	0.0618	0.803	1.000
123	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(1), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1)	4918182	8	8	8	3	5	1	0	1	1	0	0.481	0.806	1.000
124	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), LPO(5), MPO(2), TPO(6)	6374007	18	11	18	5	8	7	1	2	0	0	0.142	0.807	1.000
125	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), GH1(1), GHR(4), NFKB1(1), NFKBIA(2), PPP2CA(4), RELA(1), YWHAH(1)	7846318	15	8	15	4	3	3	1	6	2	0	0.438	0.808	1.000
126	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(7), ATP4B(2), ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(9), ATP7B(4), COX10(3), COX6B1(1), COX7A1(1), NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1), SDHA(4), SHMT1(2), UQCRC1(3), UQCRH(2)	28987012	58	33	57	9	10	10	12	17	8	1	0.00408	0.810	1.000
127	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(12), ACAT2(1), ADH5(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), DLD(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(3)	28207645	55	36	54	11	15	15	5	11	9	0	0.0187	0.815	1.000
128	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(1)	2581413	2	2	2	0	0	1	0	1	0	0	0.592	0.816	1.000
129	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(10), MAP2(8), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1)	13881910	25	12	25	4	5	4	2	8	6	0	0.186	0.828	1.000
130	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(4), CTH(1), GGT1(2), MARS(5), MARS2(2), SCLY(2), SEPHS1(1)	9435296	17	9	17	1	3	6	3	3	2	0	0.0123	0.829	1.000
131	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(4), CYP11B2(1), HSD3B1(2), HSD3B2(1)	5263021	8	8	8	3	4	0	1	1	2	0	0.522	0.831	1.000
132	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC3(1), NCK1(2), NCKAP1(4), NTRK1(3), RAC1(1), WASF1(1), WASF2(1), WASF3(3), WASL(2)	11646456	24	13	24	5	3	4	3	8	6	0	0.171	0.831	1.000
133	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(12), CPT1A(1), LEPR(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1)	11046208	22	10	22	2	6	3	1	7	5	0	0.0364	0.832	1.000
134	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(3), PLCG1(6), PRKCA(5), VAV1(5)	6908673	20	16	19	6	5	3	2	8	1	1	0.472	0.838	1.000
135	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(2), ACADS(2), ECHS1(2), HADHA(2)	4118875	9	6	9	4	2	1	1	2	3	0	0.655	0.844	1.000
136	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(4), HK2(3), HK3(3), ISYNA1(2), PGM3(1), TGDS(1)	8890894	16	10	16	2	6	5	2	2	1	0	0.0330	0.845	1.000
137	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(5), ACO2(4), DLD(1), FH(1), IDH3B(1), PC(2), PCK1(3), SDHA(4), SUCLG2(1)	14459483	22	15	21	2	6	5	5	3	3	0	0.0128	0.845	1.000
138	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), PRKACG(1), PRKAG1(1)	7703463	10	6	10	3	2	0	1	5	1	1	0.669	0.845	1.000
139	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(4), AFMID(1), HAO1(2), HAO2(1), HYI(2), MTHFD1(2), MTHFD1L(1)	10212064	18	10	18	3	3	5	2	3	5	0	0.172	0.850	1.000
140	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(4), ESR1(2), ESR2(3), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(5), NR1I2(1), NR2C2(2), NR2E1(2), NR2F1(1), NR2F2(3), NR3C1(3), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(1), PGR(4), PPARA(3), PPARG(2), RARB(2), ROR1(3), RORA(1), RORC(1), RXRA(1), RXRB(1), RXRG(3), THRA(4), THRB(2), VDR(2)	32068659	73	41	71	15	29	10	12	15	7	0	0.00874	0.854	1.000
141	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(9), DAXX(2), PAX3(1), PML(3), RB1(6), SIRT1(1), SP100(4), TNF(1), TNFRSF1B(2)	13884343	29	15	29	6	6	3	3	8	9	0	0.267	0.855	1.000
142	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(4), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(5), MARS2(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SCLY(2), SEPHS1(1), WBSCR22(3)	19003661	39	19	39	6	6	10	8	9	6	0	0.0117	0.856	1.000
143	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1)	5455379	9	4	9	0	1	3	0	4	1	0	0.0803	0.856	1.000
144	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(2), RAB3A(1), RAB9A(1)	3233959	4	3	4	0	2	1	0	1	0	0	0.225	0.856	1.000
145	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(10), NAGLU(3)	10970400	22	13	22	5	9	2	4	3	4	0	0.182	0.860	1.000
146	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(2), LDHA(1), LDHB(2), LDHC(1)	5226256	7	4	7	1	1	4	0	2	0	0	0.259	0.863	1.000
147	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(1), CSK(1), PRKCA(5), PTPRA(4)	7019909	14	7	14	4	6	2	3	2	0	1	0.340	0.866	1.000
148	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(1), UXS1(2)	3718351	5	3	5	1	0	1	2	1	1	0	0.552	0.871	1.000
149	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(3), FCGR3A(1), IL1B(2), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2)	9951983	21	13	21	5	9	6	2	2	2	0	0.0957	0.872	1.000
150	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(4), PRKACG(1), PRKAR1A(2), PRKCA(5)	7333525	14	11	14	4	6	0	1	5	1	1	0.629	0.874	1.000
151	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1)	3609161	2	2	2	0	0	0	0	1	1	0	0.606	0.884	1.000
152	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(2), RECK(3), TIMP1(1), TIMP3(1), TIMP4(2)	5742287	9	6	9	2	3	2	1	1	2	0	0.354	0.887	1.000
153	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELE(6)	9231031	21	17	20	8	8	4	6	1	2	0	0.412	0.889	1.000
154	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(4), HAO1(2), HAO2(1), HYI(2), MTHFD1(2), MTHFD1L(1)	9752655	17	9	17	3	3	5	2	3	4	0	0.175	0.889	1.000
155	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(3), EPX(5), LPO(5), MPO(2), PRDX1(1), SHMT1(2), TPO(6)	9002295	26	12	26	7	10	9	2	3	1	1	0.0825	0.890	1.000
156	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(2), SRP72(3), SRPR(5)	5765664	10	5	10	3	4	0	2	2	2	0	0.602	0.892	1.000
157	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(1)	6659547	12	5	12	3	3	3	2	3	1	0	0.415	0.895	1.000
158	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(1)	5320402	5	4	5	1	0	0	1	2	2	0	0.604	0.898	1.000
159	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(5), NRG2(1), PRKCA(5)	6884087	11	7	11	2	3	1	2	3	1	1	0.288	0.900	1.000
160	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), SHH(1), XPO1(1)	6620167	8	6	8	3	3	4	1	0	0	0	0.496	0.900	1.000
161	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(2), PON3(1)	6832399	11	7	10	4	5	0	1	3	2	0	0.671	0.902	1.000
162	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(8), ATR(6), BRCA1(2), BRCA2(9), CHEK1(3), CHEK2(3), FANCA(4), FANCC(1), FANCD2(8), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(5), RAD9A(2), TREX1(2)	33074178	62	33	61	11	13	15	11	14	9	0	0.0193	0.903	1.000
163	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), MAPK1(2), MAPK8(2), NFE2L2(1), PRKCA(5)	6757602	12	8	12	3	2	2	3	1	3	1	0.230	0.907	1.000
164	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAK1(2), BAX(1), BCL2(1), BCL2L11(1), CES1(1)	8260191	9	6	9	1	3	1	1	3	1	0	0.197	0.909	1.000
165	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CDO1(1), CTH(1), GOT1(2), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), SDS(1), SULT1B1(2), SULT1C2(3)	9563792	15	8	15	4	3	5	1	4	2	0	0.388	0.909	1.000
166	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(2), CASP10(1), CASP8(2), DFFA(2), GZMB(1), PRF1(3), SCAP(2), SREBF1(6), SREBF2(3)	13921178	25	18	25	6	9	6	4	5	1	0	0.180	0.910	1.000
167	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(2), GREB1(7), MTA3(2), PDZK1(1), TUBA8(1)	8297612	15	8	15	3	6	3	1	3	2	0	0.181	0.915	1.000
168	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4)	6095720	14	8	14	5	6	2	2	2	2	0	0.470	0.918	1.000
169	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4)	6095720	14	8	14	5	6	2	2	2	2	0	0.470	0.918	1.000
170	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(2), CREB1(1), SYT1(1)	8814705	16	7	16	4	4	5	4	0	3	0	0.170	0.919	1.000
171	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GAPDHS(1), GCK(2), GOT1(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PFKL(4), PFKP(1), PGAM2(1), PGK1(2), PKLR(3), TNFAIP1(2), TPI1(1)	31817320	60	35	59	7	21	19	3	9	8	0	4.06e-05	0.920	1.000
172	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(1), RPN1(1), RPN2(1)	9833552	14	7	14	4	4	4	2	2	2	0	0.453	0.923	1.000
173	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD4(1)	2453023	3	2	3	2	1	1	0	1	0	0	0.810	0.927	1.000
174	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(3), UGDH(1), UGP2(1), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2)	20827374	50	34	49	12	12	5	10	21	2	0	0.134	0.927	1.000
175	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), SDS(1)	3678320	8	5	8	6	3	0	2	1	2	0	0.883	0.929	1.000
176	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F2R(2), F5(7), F7(2), FGA(6), FGB(1), FGG(1), PROS1(1), SERPINC1(1)	12501458	25	20	25	8	9	1	6	7	2	0	0.404	0.930	1.000
177	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSD(3), ARSE(3), ASAH1(1), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(5), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(2), UGCG(2)	18459515	42	23	42	10	14	4	8	12	3	1	0.133	0.931	1.000
178	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT2(1), AGPAT3(1), AGPS(3), CDS2(2), CHAT(5), CHKB(1), CLC(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), ETNK1(1), GNPAT(1), LGALS13(3), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(4), PLCG1(6), PLCG2(9), PPAP2A(2), PPAP2C(1)	37972350	80	49	79	17	24	18	10	16	12	0	0.00915	0.933	1.000
179	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), DRD3(2), DRD5(3), HRH1(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1)	19607700	45	28	45	11	20	8	4	7	6	0	0.0151	0.936	1.000
180	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), NTRK1(3), PLCG1(6), PRKCA(5), SHC1(1), SOS1(4)	8981648	20	16	19	5	4	3	3	5	4	1	0.328	0.937	1.000
181	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), UGDH(1)	6500331	16	8	16	4	8	2	2	2	2	0	0.236	0.939	1.000
182	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LPL(2)	4068509	3	3	3	0	0	0	0	3	0	0	0.585	0.939	1.000
183	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(2), ACTR3(1), ARPC1A(2), ARPC1B(1), ARPC3(1), RAC1(1), WASF1(1), WASL(2)	6205319	11	5	11	2	0	2	1	6	2	0	0.351	0.940	1.000
184	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CASP8(2), CFLAR(1), DAXX(2), DFFA(2), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(3), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), PTPN13(3), RB1(6), RIPK2(1), SPTAN1(5)	30892555	51	29	51	9	10	10	8	12	10	1	0.0434	0.941	1.000
185	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(2), AXIN1(1), BTRC(1), CCND1(4), CREBBP(9), CSNK1A1(2), CSNK1D(1), CSNK2A1(2), CTBP1(5), CTNNB1(3), FZD1(2), NLK(1), PPP2CA(4), WIF1(2)	22377907	39	20	39	6	10	5	5	11	8	0	0.0394	0.941	1.000
186	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(7), EPHB1(2), FYN(1), ITGA1(2), ITGB1(2), L1CAM(7), SELP(2)	12040343	23	11	23	7	6	5	3	8	1	0	0.357	0.942	1.000
187	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(1), ABCB4(6), ABCC1(5), ABCC3(5)	10940122	22	11	22	7	4	3	3	8	3	1	0.490	0.943	1.000
188	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(3), ASAH1(1), B4GALT6(1), DEGS1(2), DEGS2(2), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(5), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(1), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(2), SPTLC2(2), UGCG(2), UGT8(1)	27198398	55	28	55	12	17	5	11	17	4	1	0.0597	0.945	1.000
189	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	11486061	13	9	13	3	3	5	3	1	0	1	0.198	0.945	1.000
190	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	11486061	13	9	13	3	3	5	3	1	0	1	0.198	0.945	1.000
191	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	11486061	13	9	13	3	3	5	3	1	0	1	0.198	0.945	1.000
192	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM3(1), CD3D(1), ELK1(3), FOS(1), FYN(1), LAT(2), LCK(1), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(5), PTPN7(2), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(4), SYT1(1), VAV1(5), ZAP70(5)	33621827	70	39	69	15	20	12	6	19	11	2	0.0154	0.946	1.000
193	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(9), EP300(5), ESR1(2), MAPK1(2), MAPK3(1), PELP1(2)	11260876	21	10	20	4	9	1	2	5	3	1	0.161	0.946	1.000
194	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5)	17549534	38	24	38	9	12	6	2	13	5	0	0.218	0.947	1.000
195	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5)	17549534	38	24	38	9	12	6	2	13	5	0	0.218	0.947	1.000
196	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(6), CREB1(1), CREB3(3), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(1), MKNK1(2), NFKB1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(4), SOS2(5), TRAF3(1)	22523028	50	27	49	12	12	3	6	17	11	1	0.210	0.948	1.000
197	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(2)	2868283	3	2	3	0	1	0	0	2	0	0	0.422	0.951	1.000
198	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(2), EGF(7), ELK1(3), FOS(1), JAK1(1), MAP3K1(3), MAPK3(1), MAPK8(2), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1)	23712295	48	32	47	11	14	9	4	11	7	3	0.0819	0.952	1.000
199	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(12), ACACB(11), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), ECHS1(2), EHHADH(1), HADHA(2), HIBCH(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SUCLG2(1)	30258890	71	37	71	17	22	16	6	16	11	0	0.0395	0.953	1.000
200	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(2), CSNK1E(1), PER1(5)	6500414	9	5	9	3	2	2	1	3	1	0	0.630	0.954	1.000
201	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), CISH(1), IARS(1), IL13RA1(3), IL4R(2), INPP5D(2), JAK1(1), JAK2(4), JAK3(3), PI3(2), PPP1R13B(1), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), STAT6(4), TYK2(7)	26474943	46	26	46	7	12	3	7	15	9	0	0.0262	0.955	1.000
202	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT5(3), GALNT6(3), GALNT8(1), GALNT9(2), GALNTL5(1), GCNT3(1), GCNT4(2), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(5)	24666893	51	31	50	11	16	11	4	14	6	0	0.0582	0.955	1.000
203	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD4(1), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(4), STAT4(2), TYK2(7)	11215590	21	8	21	6	7	2	3	7	2	0	0.397	0.958	1.000
204	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(1), PSMD1(1), PSMD11(2), PSMD2(3)	12213032	19	9	19	3	3	8	2	4	2	0	0.108	0.958	1.000
205	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GLS(2), GLS2(1), GLUD1(4), GLUL(1), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3)	25273146	43	24	43	7	10	7	6	12	8	0	0.0366	0.959	1.000
206	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(4), OAT(1), ODC1(3), SMS(2)	13339764	24	12	24	5	6	4	0	6	8	0	0.230	0.959	1.000
207	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(4), E2F1(1), MDM2(3), POLR1A(5), POLR1B(2), RAC1(1), RB1(6), TBX2(1)	11985398	27	14	27	8	5	2	3	6	11	0	0.445	0.961	1.000
208	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD3D(1), CD4(1), CD58(1), IL3(1), IL6(1), KITLG(2)	4702666	8	3	8	2	0	1	1	5	1	0	0.485	0.962	1.000
209	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK1(1), JAK2(4), STAT1(2)	6245827	8	3	8	4	1	0	1	3	2	1	0.840	0.962	1.000
210	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(7), MAPK1(2), MAPK3(1), PTPRB(6), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3)	17010062	35	23	35	8	11	2	4	6	11	1	0.210	0.964	1.000
211	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(7), MAP3K1(3), NCOR2(7), RXRA(1), THRA(4), THRB(2)	11132123	24	19	23	8	10	4	2	3	5	0	0.461	0.967	1.000
212	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2)	12217542	14	9	14	3	4	5	3	1	0	1	0.160	0.967	1.000
213	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(4), JAK3(3), PIAS3(2), PTPRU(2), REG1A(2), STAT3(2)	11601328	19	14	19	5	4	1	2	6	6	0	0.364	0.967	1.000
214	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(6), BCAR1(3), CSK(1), CTNNA2(3), CTNNB1(3), PTK2(2), VCL(1)	14626400	20	11	20	4	9	3	2	3	3	0	0.167	0.968	1.000
215	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(2), GZMB(1), HMGB2(1), TOP2A(4), TOP2B(3)	6763414	11	6	11	4	5	1	1	3	1	0	0.684	0.969	1.000
216	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(2), FOS(1), JAK2(4), MAPK3(1), MPL(2), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), THPO(1)	19989828	39	25	38	9	9	6	4	11	6	3	0.132	0.969	1.000
217	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(2), ELK1(3), FOS(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(4)	11686945	22	16	21	6	3	7	2	5	4	1	0.242	0.969	1.000
218	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(6), CPEB1(4), ERBB2(2), ERBB4(5), ETS1(3), ETV6(4), ETV7(1), FMN2(3), KRAS(3), MAPK1(2), MAPK3(1), NOTCH2(11), NOTCH3(6), NOTCH4(8), PIWIL2(3), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(4), SOS2(5), SPIRE1(1), SPIRE2(2)	34776664	79	44	78	17	20	13	12	20	12	2	0.0369	0.970	1.000
219	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG5(3), ATG7(3), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(1), ULK2(5)	15789105	26	10	26	3	6	2	5	8	5	0	0.0316	0.970	1.000
220	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(12), ACACB(11), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DLD(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(3)	35675658	72	47	71	16	24	17	6	14	11	0	0.0153	0.971	1.000
221	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1), TOB2(1)	8037390	14	7	14	4	5	4	1	3	1	0	0.320	0.974	1.000
222	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(1), FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1)	6334074	13	6	13	3	6	3	1	1	2	0	0.294	0.975	1.000
223	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(2), AGTR2(3), KNG1(2), NOS3(7), REN(2)	7529957	20	15	19	8	9	2	2	4	3	0	0.674	0.975	1.000
224	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), IKBKB(1), MAP3K1(3), MAP3K5(3), MAP4K5(1), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TNFRSF9(3), TNFSF9(2), TRAF2(2)	14757003	23	19	22	8	6	3	3	2	9	0	0.619	0.976	1.000
225	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(3), BLNK(2), ELK1(3), FOS(1), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(4), RAC1(1), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(4), VAV1(5), VAV2(2), VAV3(2)	24416270	46	25	46	11	9	8	2	15	11	1	0.143	0.976	1.000
226	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), ABAT(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(2), ASPA(1), ASS1(3), CAD(5), CRAT(1), DARS2(2), DLD(1), GAD1(2), GAD2(1), GOT1(2), NARS(1), NARS2(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1)	28831714	49	28	48	9	14	12	3	11	9	0	0.0213	0.978	1.000
227	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(2), CASP1(4), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), GZMB(1), LMNA(2), LMNB2(2), PRF1(3)	14726202	27	16	27	7	8	7	3	8	1	0	0.262	0.979	1.000
228	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(3), JAK2(4), NFKB1(1), NFKBIA(2), RELA(1), SOD2(1)	9650173	16	10	16	5	4	1	2	6	3	0	0.525	0.980	1.000
229	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(3), EPHB2(2), F2(3), F2RL1(4), F2RL3(1), MAP2K5(2), MAPK1(2), MAPK7(5), MAPK8(2), MYEF2(3), PLD1(7), PLD3(1), PTK2(2), RAF1(1), RASAL1(4), TEC(3), VAV1(5)	20931161	52	31	51	13	16	7	6	16	7	0	0.103	0.980	1.000
230	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(1)	4665623	5	2	5	5	0	1	0	3	1	0	0.980	0.980	1.000
231	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2), HSD3B7(1)	3638708	5	5	5	3	2	0	0	3	0	0	0.876	0.981	1.000
232	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(1), ABCG2(1), CES1(1), CES2(2), CYP3A4(3), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2)	17444095	29	19	28	8	8	3	7	7	4	0	0.250	0.981	1.000
233	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(3), EPO(1), EPOR(1), FOS(1), JAK2(4), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	16401154	30	20	29	8	4	7	4	9	5	1	0.205	0.981	1.000
234	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), HLA-DRA(3), HLA-DRB1(1), IFNB1(1), IL10(1), IL12B(2), IL15(2), IL3(1), IL5(1), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1)	10017261	19	12	19	6	4	2	4	7	2	0	0.468	0.982	1.000
235	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(3), HLA-DRB1(1), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), IL4R(2)	9657479	20	15	20	9	2	2	2	10	4	0	0.826	0.982	1.000
236	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(6), EIF4A2(2), EIF4B(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), MKNK1(2), PPP2CA(4), RPS6KB1(2), TSC1(2), TSC2(3)	17535248	37	25	37	9	10	8	6	9	4	0	0.165	0.982	1.000
237	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(2), AGTR2(3), CMA1(2), COL4A1(2), COL4A2(4), COL4A4(4), COL4A5(8), COL4A6(6), REN(2)	19182913	38	22	37	12	10	10	4	8	5	1	0.301	0.982	1.000
238	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1)	6644347	9	6	9	3	3	3	1	1	1	0	0.552	0.983	1.000
239	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(3), FDFT1(1), FDPS(1), HMGCS1(2), IDI1(2), LSS(1), MVD(3), NSDHL(2), SQLE(1)	10040039	18	10	18	6	6	1	3	5	3	0	0.595	0.983	1.000
240	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(1), JAK2(4), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(2), REG1A(2), SOAT1(2)	10445505	18	13	18	9	2	1	3	6	6	0	0.867	0.983	1.000
241	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), FHL5(3), FSHR(2), GNAS(4), XPO1(1)	7316980	12	11	12	4	3	1	3	3	2	0	0.663	0.984	1.000
242	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(7), IRS1(4), MAPK1(2), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), YWHAH(1)	11592769	22	16	22	5	5	4	3	3	6	1	0.151	0.984	1.000
243	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(3), PLCB2(4), PRL(1), VIP(2)	8487670	18	15	18	6	6	4	0	5	3	0	0.497	0.986	1.000
244	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(2), REG1A(2), STAT1(2), STAT2(1), TYK2(7)	9519803	18	11	18	6	4	1	1	6	5	1	0.517	0.986	1.000
245	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1)	7707321	15	10	15	5	5	2	1	4	3	0	0.655	0.987	1.000
246	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(4), PRKAR1A(2)	5040026	8	8	8	3	4	0	0	2	2	0	0.717	0.987	1.000
247	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(4), COL4A4(4), COL4A5(8), COL4A6(6), SLC23A1(1), SLC23A2(3), SLC2A1(2), SLC2A3(3)	19031248	33	20	33	10	12	7	4	6	3	1	0.151	0.987	1.000
248	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(2), HADHA(2), HSD17B4(2), MECR(1), PPT2(1)	6456563	11	8	11	6	2	1	2	3	3	0	0.852	0.988	1.000
249	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1)	5303323	9	4	9	4	0	0	2	4	3	0	0.857	0.988	1.000
250	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(5), CPT1A(1), CPT2(1), EHHADH(1), HADHA(2), PECR(2), SCP2(1), SLC25A20(1)	12822677	26	15	26	7	2	6	2	7	9	0	0.306	0.988	1.000
251	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(1), RAF1(1)	6275748	8	4	8	3	1	3	1	0	2	1	0.357	0.988	1.000
252	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(2), ELK1(3), FOS(1), INSR(4), IRS1(4), MAPK3(1), MAPK8(2), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2)	16571009	37	24	35	10	9	10	2	10	5	1	0.184	0.989	1.000
253	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK1(1), JAK2(4), PTPRU(2), REG1A(2), STAT1(2)	8703704	12	6	12	6	2	1	1	3	4	1	0.733	0.989	1.000
254	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(2), ITGAM(2), ITGB2(1), SELE(6)	7911970	16	13	15	7	8	4	3	0	1	0	0.463	0.990	1.000
255	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAPK1(2), MAPK3(1), NFKB1(1), RB1(6), RELA(1)	11935182	20	10	20	8	6	2	3	1	7	1	0.732	0.990	1.000
256	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), CDKN1A(1), ELK1(3), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CD(3), SHC1(1), SOS1(4)	10629239	18	11	18	5	6	2	1	5	4	0	0.348	0.990	1.000
257	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(2), ASPA(1), CAD(5), CRAT(1), GAD1(2), GAD2(1), GOT1(2), NARS(1), PC(2)	19858601	31	15	31	4	8	8	1	8	6	0	0.0206	0.990	1.000
258	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(3), ATM(8), BAX(1), BCL2(1), CYCS(2), PRKCA(5), PTK2(2), STAT1(2), TLN1(5)	20253319	30	17	30	7	6	2	4	13	3	2	0.266	0.990	1.000
259	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(9), EP300(5), LPL(2), NCOA1(2), NCOA2(2), PPARG(2), RXRA(1)	14092549	23	14	22	7	6	5	1	9	2	0	0.443	0.991	1.000
260	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), CASP8(2), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	6390003	12	11	12	5	4	3	1	1	3	0	0.638	0.991	1.000
261	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), SDS(1)	5937443	8	6	8	7	2	1	1	2	2	0	0.949	0.992	1.000
262	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(1), ASAH1(1), ATF1(1), BRAF(6), CREB1(1), CREB3(3), CREBBP(9), CRKL(1), DAG1(1), EGR1(2), EGR3(1), ELK1(3), FRS2(1), MAP1B(8), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(2), NTRK1(3), OPN1LW(1), PIK3C2G(1), PIK3CD(3), PTPN11(7), RPS6KA3(3), SHC1(1), TERF2IP(1), TH(3)	36322516	77	47	74	19	15	10	12	24	15	1	0.0759	0.992	1.000
263	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	23	FBP2(1), GAA(5), GANAB(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), LCT(10), MGAM(9), PFKP(1), PGM3(1)	24223151	48	27	48	11	25	7	5	8	3	0	0.0315	0.992	1.000
264	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(1), FDPS(1), IDI1(2), LSS(1), MVD(3), NQO1(1), NQO2(1), SQLE(1)	8415107	14	7	14	5	4	1	3	3	3	0	0.614	0.992	1.000
265	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B10(2), G6PC2(1), GAA(5), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), LCT(10), MGAM(9), PFKL(4), PFKP(1), PGM3(1), UGP2(1)	28837191	56	30	56	13	28	7	5	12	4	0	0.0254	0.992	1.000
266	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1A(1), BMPR1B(1)	4799181	5	4	5	4	2	0	1	1	1	0	0.968	0.992	1.000
267	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), HSD17B4(2), SIRT1(1), SIRT5(2), SIRT7(1)	9016735	13	9	13	9	3	0	2	4	4	0	0.957	0.992	1.000
268	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), FOS(1), IL3(1), IL3RA(2), JAK2(4), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	13498729	20	11	20	5	3	2	3	7	4	1	0.312	0.993	1.000
269	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(3), ACAT2(1), ECHS1(2), EHHADH(1), HADHA(2), SDS(1)	6374315	10	8	10	9	2	1	2	2	3	0	0.970	0.993	1.000
270	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(3), ACO1(5), ACO2(4), CLYBL(1), DLD(1), FH(1), IDH3B(1), OGDH(1), OGDHL(4), PC(2), PCK1(3), SDHA(4), SDHC(2), SUCLG2(1)	21516939	33	22	32	9	10	6	7	6	4	0	0.154	0.993	1.000
271	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1)	5245630	9	7	9	4	4	2	2	0	1	0	0.817	0.993	1.000
272	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(2), ATF2(2), AXIN1(1), BMP10(2), BMP4(2), BMP5(4), BMPR1A(1), CHRD(1), CTNNB1(3), FZD1(2), GATA4(1), MYL2(2), RFC1(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2)	27739741	37	21	37	7	13	5	4	5	10	0	0.0807	0.993	1.000
273	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RELA(1)	6279992	12	9	12	7	3	0	1	6	1	1	0.889	0.994	1.000
274	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST13(2), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(2), SUOX(1)	7003860	13	9	13	6	2	1	0	8	2	0	0.840	0.994	1.000
275	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(2), GLB1(2), HEXA(1), HEXB(1), LCT(10), SLC33A1(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3)	12575808	29	18	29	9	11	1	4	5	8	0	0.581	0.994	1.000
276	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(4), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC2(1), GALM(1), GAPDHS(1), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKL(4), PFKP(1), PGAM2(1), PGAM4(1), PGK1(2), PGM3(1), PKLR(3), TPI1(1)	43781374	90	48	89	20	32	19	8	20	11	0	0.00311	0.994	1.000
277	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(8), ATR(6), CHEK1(3), CHEK2(3), YWHAH(1)	11602806	21	10	21	5	4	4	3	5	5	0	0.423	0.995	1.000
278	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), ABAT(1), ACADS(2), ACAT2(1), ACSM1(5), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCS1(2), HMGCS2(3), HSD17B4(2), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), PLA1A(3)	30882332	67	37	66	18	19	9	7	21	11	0	0.0910	0.995	1.000
279	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(6), BAIAP2(3), CASP1(4), CASP8(2), INSR(4), MAGI1(4), MAGI2(4), RERE(7), WWP1(3), WWP2(1)	18276470	38	22	38	10	13	8	3	10	4	0	0.224	0.995	1.000
280	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(2), ELK1(3), FOS(1), JAK1(1), MAP3K1(3), MAPK3(1), MAPK8(2), PDGFA(1), PDGFRA(18), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1)	23775284	60	36	57	15	11	15	6	15	10	3	0.112	0.995	1.000
281	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(2), CALM3(1), ELK1(3), FCER1A(2), FOS(1), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PAK2(2), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1), VAV1(5)	29978997	56	32	55	13	12	10	8	18	7	1	0.0567	0.995	1.000
282	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1)	4304453	7	7	7	4	3	0	1	2	1	0	0.892	0.995	1.000
283	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(3), RPL10L(1), RPL13A(1), RPL18A(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(2), RPS2(1), RPS24(1), RPS3(3)	17172785	24	12	24	3	8	1	4	7	4	0	0.151	0.996	1.000
284	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	EPO(1), FLT3(4), IGF1(1), IL3(1), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1)	6198671	14	7	14	6	3	2	3	5	1	0	0.728	0.996	1.000
285	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT2(2), GCNT2(1), ST8SIA1(1)	4681304	4	2	4	4	1	1	0	1	1	0	0.983	0.996	1.000
286	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), NTRK1(3), PLCG1(6), RPS6KA1(4), SHC1(1)	11542170	27	18	26	9	3	5	3	7	8	1	0.517	0.996	1.000
287	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHPF(1), CHST11(3), CHST13(2), CHST3(3), CHSY1(2), DSE(3), XYLT1(2), XYLT2(1)	10706660	17	12	17	5	6	2	1	6	2	0	0.412	0.996	1.000
288	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(1), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), MPI(1), PFKFB1(4), PFKFB3(2), PFKP(1), SORD(1), TPI1(1)	18222971	30	14	30	8	11	9	1	5	4	0	0.0902	0.997	1.000
289	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(12), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ECHS1(2), EHHADH(1), HADHA(2), LDHA(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SDS(1), SUCLG2(1)	25260109	54	26	54	14	14	14	4	13	9	0	0.128	0.997	1.000
290	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(1), BRAF(6), CAB39(2), EIF4B(2), IGF1(1), MAPK1(2), MAPK3(1), PGF(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(3), ULK1(1), ULK2(5), VEGFA(2), VEGFB(2), VEGFC(2)	37643836	71	39	69	16	18	7	13	21	11	1	0.0599	0.997	1.000
291	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2)	12241106	17	10	17	6	4	2	1	9	1	0	0.717	0.997	1.000
292	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(4), CREBBP(9), EP300(5), MAPK3(1), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3)	19594517	32	13	32	7	9	4	3	12	3	1	0.220	0.997	1.000
293	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(2), CCNB1(2), GNAI1(4), GNAS(4), MAPK1(2), MAPK3(1), MYT1(7), PRKACG(1), PRKAR1A(2), RPS6KA1(4)	15657241	29	24	29	9	7	0	4	5	12	1	0.633	0.997	1.000
294	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AGPAT2(1), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CEL(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), GK(1), GLA(2), GLB1(2), LCT(10), LIPC(1), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(4), PPAP2A(2), PPAP2C(1)	36638110	76	35	76	19	27	10	13	19	7	0	0.0325	0.997	1.000
295	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(12), ACACB(11), FASN(3), MCAT(3), OXSM(2)	12024579	31	21	31	10	8	6	4	7	6	0	0.316	0.998	1.000
296	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(1), ALAS2(1), BLVRA(2), COX10(3), COX15(1), CP(3), EARS2(1), EPRS(3), FECH(1), FTH1(3), GUSB(3), HCCS(4), MMAB(2), PPOX(1), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2), UROD(1), UROS(1)	32174527	78	50	77	20	20	10	16	30	2	0	0.0942	0.998	1.000
297	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), AP2M1(1), BIN1(2), CALM3(1), DNM1(1), EPN1(1), EPS15(1), PICALM(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYNJ1(6), SYNJ2(9), SYT1(1)	16393408	29	14	29	9	8	5	5	5	6	0	0.342	0.998	1.000
298	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(3), APOBEC3B(1), APOBEC3C(1), APOBEC3F(2), APOBEC3G(1), APOBEC4(1)	5595902	13	12	13	5	4	3	0	5	1	0	0.612	0.998	1.000
299	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	12645156	12	5	11	1	5	3	1	2	1	0	0.0852	0.998	1.000
300	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), RAC1(1), RAF1(1), RALA(2), RALBP1(2), RALGDS(2), RELA(1)	11643722	16	6	16	8	3	1	1	4	6	1	0.816	0.998	1.000
301	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(1), CYP4B1(1), CYP51A1(2), PON1(2)	22281676	41	35	41	10	16	3	4	8	10	0	0.185	0.998	1.000
302	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1)	8181990	13	7	13	7	4	2	1	3	3	0	0.896	0.999	1.000
303	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(2), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EARS2(1), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GFPT2(3), GLS(2), GLS2(1), GLUD1(4), GLUD2(1), GLUL(1), GNPNAT1(2), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3)	30078426	52	28	52	12	10	9	8	15	10	0	0.123	0.999	1.000
304	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(1), GLUD1(4), GLUD2(1)	3477988	8	7	8	4	1	2	0	4	1	0	0.840	0.999	1.000
305	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(4), HSD17B4(2), HSD17B7(2), HSD3B1(2), HSD3B2(1)	6177440	11	11	10	6	2	3	3	2	1	0	0.758	0.999	1.000
306	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(3), ACADM(2), ACADS(2), ACAT2(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), DBT(2), DLD(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), HIBCH(1), HMGCS1(2), HMGCS2(3), HSD17B4(2), MCCC1(3), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3)	32766155	67	34	66	17	20	15	6	14	12	0	0.0871	0.999	1.000
307	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(2), CALM3(1), CD79A(1), ELK1(3), FOS(1), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(5), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1), VAV1(5)	29168505	55	30	54	14	14	9	5	16	9	2	0.0993	0.999	1.000
308	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(3)	6665765	11	8	11	7	8	2	0	0	1	0	0.731	0.999	1.000
309	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2)	10101558	26	12	26	10	9	2	3	10	2	0	0.584	0.999	1.000
310	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), ASAH1(1), BRAF(6), DAG1(1), EPHB2(2), ITPR1(4), ITPR2(12), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PI3(2), PIK3CB(3), PITX2(4), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT3(2), TERF2IP(1)	42599249	84	46	83	20	21	8	19	28	7	1	0.0558	0.999	1.000
311	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT6(1), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CEL(2), DAK(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), GK(1), GK2(4), GLA(2), GLB1(2), GPAM(1), LCT(10), LIPA(2), LIPC(1), LIPG(3), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1)	44636438	91	40	91	22	33	10	16	24	8	0	0.0193	0.999	1.000
312	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGW(2), PIGX(1), PIGZ(1)	18144274	26	9	26	7	9	2	5	6	4	0	0.261	0.999	1.000
313	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1)	5870532	7	3	7	4	1	2	1	0	3	0	0.869	0.999	1.000
314	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1), LARS(4), PDHA1(5), PDHA2(4), PDHB(1)	7640916	16	11	15	6	1	5	2	4	4	0	0.627	0.999	1.000
315	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(2), EIF2S2(1), NFKB1(1), NFKBIA(2), RELA(1)	6816905	7	4	7	4	1	2	0	3	1	0	0.846	0.999	1.000
316	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(1)	5006724	5	5	5	3	2	2	0	1	0	0	0.677	0.999	1.000
317	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(1)	5006724	5	5	5	3	2	2	0	1	0	0	0.677	0.999	1.000
318	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2)	13642820	26	9	26	9	6	7	5	3	4	1	0.311	0.999	1.000
319	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), HADHA(2), PNPLA3(1), SH3GLB1(3)	23564980	41	22	40	11	18	6	5	6	6	0	0.148	0.999	1.000
320	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(3), TPI1(1)	36679512	73	41	72	19	24	18	7	16	8	0	0.0306	0.999	1.000
321	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(3), TPI1(1)	36679512	73	41	72	19	24	18	7	16	8	0	0.0306	0.999	1.000
322	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(2), IRS1(4), JAK1(1), JAK3(3), RPS6KB1(2), SHC1(1), STAT6(4)	11274265	18	13	18	6	3	3	1	7	4	0	0.556	0.999	1.000
323	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(7), PRKACG(1), PRKAR1A(2)	9836712	14	11	14	5	4	1	2	5	1	1	0.561	1.000	1.000
324	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM3(1), CRKL(1), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PRKCA(5), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1)	21754827	40	26	39	11	9	9	6	6	8	2	0.132	1.000	1.000
325	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), IARS2(3), ILVBL(5), LARS(4), PDHA1(5), PDHA2(4), PDHB(1), VARS(3), VARS2(1)	14152220	28	16	27	8	4	7	2	10	5	0	0.407	1.000	1.000
326	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCL2(1), BCR(3), CRKL(1), FOS(1), JAK2(4), MAP3K1(3), MAPK3(1), MAPK8(2), RAF1(1), SOS1(4), STAT1(2), STAT5A(1), STAT5B(2)	18561700	27	13	27	8	6	6	3	7	3	2	0.239	1.000	1.000
327	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(4), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2)	11711537	20	11	20	6	8	1	0	8	3	0	0.591	1.000	1.000
328	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	48	AGT(2), AKT1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(9), CSNK1A1(2), F2(3), GATA4(1), IGF1(1), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RAF1(1), RPS6KB1(2), SYT1(1)	32828496	53	27	53	13	14	6	8	15	9	1	0.0680	1.000	1.000
329	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(6), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(3), PTK2(2), RAC1(1), SPTAN1(5), TLN1(5)	21754738	29	13	29	7	9	3	7	7	3	0	0.195	1.000	1.000
330	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NFKB1(1), NOX1(1), RELA(1), TNF(1), XDH(8)	7555417	13	6	13	7	3	4	0	5	1	0	0.782	1.000	1.000
331	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(4)	7056883	12	4	12	5	3	1	3	4	1	0	0.746	1.000	1.000
332	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(2), F2RL3(1), GNAI1(4), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(3), PRKCA(5), PTGS1(2), PTK2(2), RAF1(1), TBXAS1(1)	18595668	35	25	35	10	5	1	9	14	4	2	0.352	1.000	1.000
333	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(3), BCL2(1), CYCS(2), DAXX(2), FAS(1), FASLG(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1)	8644454	13	6	13	5	0	3	3	6	1	0	0.740	1.000	1.000
334	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(1)	3969620	1	1	1	1	1	0	0	0	0	0	0.944	1.000	1.000
335	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFA(2), LMNA(2), LMNB2(2), MADD(2), MAP3K1(3), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), RB1(6), RIPK1(3), SPTAN1(5), TNF(1), TRADD(1), TRAF2(2)	29449092	52	37	52	12	13	10	8	9	11	1	0.123	1.000	1.000
336	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(1), GNAS(4), PLCE1(8), PRKACG(1), PRKAR1A(2), RAP2B(2)	11278800	20	15	20	7	9	4	1	3	3	0	0.540	1.000	1.000
337	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(1), IL18(3), ITGB1(2), KLRC1(2), KLRC2(1), LAT(2), MAPK3(1), PAK1(2), PTK2B(2), RAC1(1), VAV1(5)	11329849	22	11	22	7	5	3	2	5	6	1	0.389	1.000	1.000
338	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(2), ALOX5(1), CYP1A2(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	18196334	38	30	38	11	12	5	5	8	8	0	0.290	1.000	1.000
339	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), EPO(1), IL3(1), IL5(1), IL6(1), IL9(1)	4546118	6	4	6	5	1	0	0	4	1	0	0.961	1.000	1.000
340	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(5), AKT1(1), ATM(8), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(1), MAPK8(2), MDM2(3), NQO1(1)	15228771	26	15	26	9	5	2	3	11	5	0	0.694	1.000	1.000
341	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	19045120	26	11	25	9	6	5	2	12	1	0	0.607	1.000	1.000
342	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(2), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2)	8449322	13	8	13	7	1	4	2	5	1	0	0.823	1.000	1.000
343	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(1), CFTR(4), GNAS(4), PRKACG(1), PRKAR1A(2), SLC9A3R1(1)	9985321	15	13	15	5	7	2	1	3	2	0	0.550	1.000	1.000
344	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(2), AKT1(1), ASAH1(1), GNAI1(4), ITGAV(2), ITGB3(3), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(18), PLCB1(3), PRKCA(5), PTK2(2), RAC1(1), SMPD1(1), SMPD2(1)	18049301	48	27	46	14	6	8	11	12	9	2	0.244	1.000	1.000
345	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	CES1(1)	4606534	1	1	1	1	0	1	0	0	0	0	0.829	1.000	1.000
346	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ACADM(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HIBCH(1), MLYCD(3), SMS(2), SRM(2)	20575775	44	19	43	14	15	6	4	11	8	0	0.301	1.000	1.000
347	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(1), CASP8(2), CYCS(2), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(1), TRADD(1), TRAF2(2)	15647175	25	17	25	9	6	5	4	4	5	1	0.449	1.000	1.000
348	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNB1(2), CHRNG(2), MUSK(4), PTK2(2), PTK2B(2), RAPSN(1), TERT(2), YWHAH(1)	9555271	17	12	17	8	5	1	2	7	2	0	0.800	1.000	1.000
349	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), EPRS(3), FARS2(3), GARS(3), HARS(2), IARS(1), LARS(4), MARS(5), MARS2(2), NARS(1), QARS(3), RARS(2), SARS(1), WARS2(2), YARS(1)	24437873	36	18	36	9	5	11	3	11	6	0	0.284	1.000	1.000
350	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1)	10310202	16	11	16	6	5	2	2	6	1	0	0.626	1.000	1.000
351	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RAF1(1), RELA(1), TNF(1)	11846307	18	13	18	9	3	2	2	6	3	2	0.708	1.000	1.000
352	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), SDS(1)	19672597	42	26	41	14	13	7	4	9	9	0	0.233	1.000	1.000
353	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), BRD4(1), CBL(1), CDKN2A(4), FLOT1(1), FLOT2(3), INPPL1(5), IRS1(4), IRS2(1), IRS4(5), LNPEP(1), MAPK1(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CD(3), PTPN1(1), RAF1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(4), SOS2(5), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	41884312	73	39	73	17	14	9	12	23	14	1	0.0608	1.000	1.000
354	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	11	CBS(4), CTH(1), DNMT1(3), DNMT3B(4), MARS(5), MARS2(2), MTR(2)	11879988	21	8	21	9	5	6	0	6	2	2	0.618	1.000	1.000
355	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM3(1), CXCR4(2), FOS(1), MAPK8(2), PLCG1(6), PRKCA(5), PTK2B(2), SYT1(1)	10519687	20	18	19	9	3	6	5	4	1	1	0.570	1.000	1.000
356	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), CDK2(1), CDKN1B(3), CDKN2A(4), CREB1(1), CREB3(3), ERBB4(5), IGF1(1), INPPL1(5), IRS1(4), IRS2(1), IRS4(5), MET(10), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PARD3(2), PARD6A(1), PDK1(2), PIK3CD(3), PPP1R13B(1), PREX1(5), PTK2(2), PTPN1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(5), TSC1(2), TSC2(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	56592728	113	59	113	27	22	15	20	35	21	0	0.0357	1.000	1.000
357	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(1), ANXA1(2), CALM3(1), GNAS(4), NFKB1(1), NOS3(7), NR3C1(3), RELA(1), SYT1(1)	10767148	22	16	22	8	10	3	3	4	2	0	0.581	1.000	1.000
358	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(5), GRAP2(1), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(2), NCK1(2), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PLCG1(6), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), SOS1(4), SOS2(5), VAV1(5), ZAP70(5)	42431766	86	48	85	21	24	18	8	21	15	0	0.0462	1.000	1.000
359	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(6), CALM3(1), CAPNS1(1), CAPNS2(1), EP300(5), HDAC2(4), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(5), SYT1(1)	18592690	34	18	34	11	9	4	5	9	6	1	0.438	1.000	1.000
360	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME2(1), ME3(1), PGK1(2), PKLR(3), RPIA(1), TKT(2), TPI1(1)	13758488	18	11	18	6	5	4	1	5	3	0	0.497	1.000	1.000
361	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10(1), IL10RB(1), IL6(1), JAK1(1), STAT1(2), STAT3(2), STAT5A(1), TNF(1)	9265383	12	7	12	6	3	1	2	5	0	1	0.784	1.000	1.000
362	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CREB1(1), DAXX(2), DDIT3(1), ELK1(3), HMGN1(1), MAP3K1(3), MAP3K5(3), MAP3K9(3), MAPKAPK2(1), MAPKAPK5(2), MAX(5), MEF2A(2), MEF2B(1), MKNK1(2), PLA2G4A(4), RAC1(1), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	27928825	52	31	50	14	14	7	9	12	9	1	0.223	1.000	1.000
363	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT2(1), AGPAT3(1), AGPAT6(1), CDS2(2), CHAT(5), CHKB(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), ESCO1(1), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(1), GPAM(1), LYPLA1(1), PCYT1B(1), PHOSPHO1(1), PISD(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(2), SH3GLB1(3)	49859830	71	33	71	15	23	18	8	13	9	0	0.00859	1.000	1.000
364	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(2), AXIN1(1), BTRC(1), CTNNB1(3), FZD1(2)	13220295	9	6	9	5	2	1	1	2	3	0	0.920	1.000	1.000
365	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	ELK1(3), GNAS(4), IGF1R(7), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(2), NGFR(1), PDGFRA(18), PPP2CA(4), PTPRR(3), RAF1(1), RPS6KA1(4), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(2)	23211004	61	37	59	17	13	11	8	15	13	1	0.230	1.000	1.000
366	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(1), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), MPI(1), MTMR1(4), MTMR2(3), MTMR6(1), PFKFB1(4), PFKFB2(2), PFKFB3(2), PFKL(4), PFKP(1), PGM2(4), SORD(1), TPI1(1), TSTA3(1)	28312461	50	24	50	14	18	10	4	10	8	0	0.124	1.000	1.000
367	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(4), INSR(4), IRS1(4), JAK2(4), MAPK1(2), MAPK3(1), PLCG1(6), PRKCA(5), RAF1(1), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2), STAT5A(1), STAT5B(2)	22362393	47	29	46	14	9	10	6	13	7	2	0.256	1.000	1.000
368	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(1), APC(2), AR(4), ASAH1(1), BRAF(6), CCL16(1), DAG1(1), GNA11(1), GNA15(1), GNAI1(4), ITPR1(4), ITPR2(12), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), MAPK10(1), PHKA2(5), PIK3CD(3), PITX2(4), PTX3(2), RAF1(1)	35864860	74	43	73	22	17	7	22	19	7	2	0.247	1.000	1.000
369	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), BCR(3), BTK(2), CD19(1), CDKN2A(4), FLOT1(1), FLOT2(3), ITPR1(4), ITPR2(12), ITPR3(13), PDK1(2), PHF11(1), PITX2(4), PLCG2(9), PPP1R13B(1), PREX1(5), PTPRC(7), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SAG(2), TEC(3), VAV1(5)	39779544	95	51	95	27	30	12	14	28	10	1	0.0918	1.000	1.000
370	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(2), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), MAOA(2), TAT(1), TH(3), TPO(6), TYR(4)	24148464	59	32	59	20	21	7	6	19	6	0	0.280	1.000	1.000
371	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK8(2), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(1), TRAF5(3)	11076415	13	8	13	7	5	4	2	1	1	0	0.789	1.000	1.000
372	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(2), ECH1(1), ESCO1(1), ESCO2(2), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SH3GLB1(3), TAT(1), TH(3), TPO(6), TYR(4), TYRP1(4), WBSCR22(3)	45304110	94	45	93	27	26	15	12	28	13	0	0.102	1.000	1.000
373	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), ETV5(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), JAK2(4), MAPK8(2), STAT4(2), TYK2(7)	14234081	29	15	29	10	8	3	6	10	2	0	0.543	1.000	1.000
374	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(3), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2), TRAF3(1)	13825823	13	9	13	9	7	1	1	2	2	0	0.909	1.000	1.000
375	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(2), FTCD(4), HAL(1), HARS(2), HARS2(1), HDC(2), HNMT(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(3)	30196195	64	35	64	20	24	10	9	14	7	0	0.165	1.000	1.000
376	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), SELE(6), SELP(2)	12153975	25	19	24	10	9	4	7	3	2	0	0.496	1.000	1.000
377	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(2), AKT1(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(4), MAPK1(2), MAPK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAC1(1), RPS6KA1(4), RPS6KA5(1), SOS1(4)	19338142	35	21	35	10	12	2	5	6	8	2	0.322	1.000	1.000
378	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), MCCC1(3), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3), SDS(1)	27454596	56	29	55	18	15	16	5	11	9	0	0.249	1.000	1.000
379	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(6), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1(1), IGF1R(7), INSR(4), MAPK7(5), MEF2A(2), MEF2B(1), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYT1(1), YWHAH(1)	23645827	43	24	43	14	13	7	6	10	7	0	0.279	1.000	1.000
380	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(3), CALM3(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNA11(1), GNAI1(4), JAK2(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), MYLK(5), PLCG1(6), PRKCA(5), PTK2B(2), RAF1(1), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), SYT1(1)	31773570	61	35	60	18	15	8	13	14	8	3	0.159	1.000	1.000
381	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(3), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR1(1), KDELR2(1), KDELR3(1)	12375308	15	9	15	6	3	4	3	2	3	0	0.602	1.000	1.000
382	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(4), FH(1), OGDH(1), SDHA(4)	6575295	10	8	9	5	4	0	4	1	1	0	0.722	1.000	1.000
383	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM3(1), DLG4(3), GRIN1(3), GRIN2A(7), GRIN2B(6), GRIN2C(4), GRIN2D(4), NOS1(5), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), SYT1(1)	19464413	45	36	45	16	17	6	7	10	4	1	0.343	1.000	1.000
384	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), GLI2(2), GLI3(5), PRKACG(1), PRKAR1A(2), SHH(1), SMO(2), SUFU(3)	12703482	19	12	19	9	6	5	2	4	2	0	0.710	1.000	1.000
385	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(8), ATR(6), BAI1(4), BAX(1), CASP8(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), CYCS(2), DDB2(2), EI24(4), FAS(1), GTSE1(4), IGF1(1), MDM2(3), MDM4(1), PPM1D(3), RCHY1(1), RFWD2(4), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(1), SESN3(1), SFN(2), SIAH1(3), STEAP3(2), THBS1(4), TP53I3(1), TSC2(3), ZMAT3(3)	48515468	104	61	103	28	20	14	21	28	21	0	0.0920	1.000	1.000
386	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(2), SHC1(1), SOS1(4)	6731930	8	6	8	4	1	2	0	3	2	0	0.730	1.000	1.000
387	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(2), BAX(1), BFAR(1), BTK(2), CAD(5), CASP10(1), CASP8(2), CD7(1), CSNK1A1(2), DAXX(2), DEDD2(1), DFFA(2), DIABLO(2), EPHB2(2), FAF1(3), MAP3K1(3), MAP3K5(3), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(2), MET(10), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), RIPK1(3), ROCK1(2), SMPD1(1), TNFRSF6B(1), TPX2(5), TRAF2(2), TUFM(1)	52787417	87	44	87	20	28	13	12	16	18	0	0.0238	1.000	1.000
388	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), ATF2(2), CALM3(1), ELK1(3), MAP2K2(1), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(5), PTK2(2), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1)	23541751	39	21	39	12	7	7	5	8	10	2	0.297	1.000	1.000
389	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	CES1(1), ESCO1(1), ESCO2(2), LIPA(2), PLA1A(3), PNPLA3(1), SH3GLB1(3)	19324133	13	4	13	3	2	4	1	4	2	0	0.342	1.000	1.000
390	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(2), FUCA2(4), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(1), IDS(2), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(1), NEU2(5), NEU3(2), SPAM1(3)	26265325	61	41	61	19	22	5	10	15	9	0	0.304	1.000	1.000
391	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM3(1), CREB1(1), ELK1(3), FOS(1), GNAI1(4), GNAS(4), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAF1(1), RPS6KA3(3), SYT1(1)	26677921	51	35	50	16	13	5	7	14	10	2	0.332	1.000	1.000
392	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CSK(1), F11R(1), GIT1(2), HBEGF(1), IKBKB(1), JAM2(4), JAM3(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(2), MAPK9(2), MET(10), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(1), PAK1(2), PLCG1(6), PLCG2(9), PTPN11(7), PTPRZ1(12), RAC1(1), RELA(1), TCIRG1(2), TJP1(5)	51558914	99	59	96	26	23	15	16	22	22	1	0.0599	1.000	1.000
393	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME3(1), PGK1(2), PKLR(3), RPIA(1), TKT(2), TKTL2(2), TPI1(1)	15384007	19	12	19	8	5	4	1	5	4	0	0.711	1.000	1.000
394	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(2), CYP11B2(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SRD5A1(1), SULT2A1(2), SULT2B1(2), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2), WBSCR22(3)	38270867	88	57	86	28	21	12	18	30	7	0	0.198	1.000	1.000
395	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(1), BTK(2), CDKN2A(4), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SOS1(4), SOS2(5), TEC(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	25125159	48	27	48	14	7	5	10	17	9	0	0.347	1.000	1.000
396	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), ASAH1(1), CREB1(1), CREB3(3), DAG1(1), EPHB2(2), FOS(1), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(2)	21844628	25	17	25	8	5	4	5	5	6	0	0.408	1.000	1.000
397	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2)	14430898	30	13	30	11	8	7	5	4	5	1	0.388	1.000	1.000
398	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(4), IRS1(4), MAPK1(2), MAPK3(1), MKNK1(2), PABPC1(4), PRKCA(5), RPS6KB1(2)	17956583	46	28	46	14	13	9	7	8	7	2	0.328	1.000	1.000
399	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM3(1), EGR3(1), MAP3K1(3), NFATC1(2), NFATC2(5), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), SYT1(1), VIP(2), VIPR2(1)	21363306	32	23	31	11	7	4	2	14	5	0	0.565	1.000	1.000
400	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(5), PER2(3), PER3(1)	13016512	16	6	16	8	2	4	1	8	1	0	0.877	1.000	1.000
401	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR161(1), GPR171(1), GPR18(2), GPR34(2), GPR45(1), GPR75(1)	7509135	11	7	11	9	3	2	2	2	2	0	0.929	1.000	1.000
402	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), SLC2A4(1), SYT1(1), YWHAH(1)	15426037	26	10	26	9	6	7	4	3	6	0	0.405	1.000	1.000
403	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(3), ALG6(3), DAD1(1), DHDDS(1), DPAGT1(2), DPM1(2), FUT8(6), GANAB(5), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(2), RPN1(1), RPN2(1), ST6GAL1(1), STT3B(2)	32247634	61	33	61	18	13	16	10	8	14	0	0.228	1.000	1.000
404	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(2), ASAH1(1), DAG1(1), DLG4(3), EPHB2(2), GNAI1(4), ITPR1(4), ITPR2(12), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PITX2(4), PTX3(2), RAC1(1), RYR1(11)	34848750	68	38	68	21	17	8	17	16	9	1	0.237	1.000	1.000
405	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(1), CBR3(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2U1(1), CYP4A11(1), CYP4A22(2), CYP4F3(4), DHRS4(1), EPHX2(2), GGT1(2), GPX2(2), GPX4(1), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(1)	29656133	64	46	64	19	18	10	8	14	14	0	0.190	1.000	1.000
406	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), BPNT1(1), ILK(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(3), PTK2B(2), RBL2(3), SHC1(1), SOS1(4)	13259571	21	13	21	9	4	4	1	9	2	1	0.693	1.000	1.000
407	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(8), ATR(6), BRCA1(2), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(1), CHEK1(3), CHEK2(3), EP300(5), MDM2(3), MYT1(7), PRKDC(11), RPS6KA1(4), WEE1(1), YWHAH(1), YWHAQ(1)	31186534	62	36	62	17	14	6	7	18	16	1	0.439	1.000	1.000
408	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), GCDH(1), HADHA(2), PNPLA3(1), SH3GLB1(3)	19795829	21	10	20	8	7	4	3	4	3	0	0.556	1.000	1.000
409	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(4), DLD(1), FH(1), IDH3B(1), OGDH(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1), PDK1(2), PDK3(3), PDK4(1), PDP2(2), SDHA(4), SDHC(2), SUCLG2(1)	21037830	35	23	33	12	7	6	7	9	6	0	0.398	1.000	1.000
410	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), CFL1(1), CFL2(1), FLNA(13), FLNC(12), FSCN1(2), FSCN2(1), FSCN3(3), GDI1(3), GDI2(1), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), ROCK1(2), ROCK2(4), RPS4X(2), WASF1(1), WASL(2)	33486860	80	43	80	27	27	13	10	20	9	1	0.211	1.000	1.000
411	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(13), C5(6), C6(3), C7(5), ICAM1(2), IL6(1), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1)	18896072	45	29	45	18	14	6	7	11	7	0	0.479	1.000	1.000
412	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	CRKL(1), DOCK1(1), ELK1(3), FOS(1), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAP4K1(1), MAPK1(2), MAPK3(1), MAPK8(2), MET(10), PAK1(2), PTK2(2), PTK2B(2), PTPN11(7), RAF1(1), RASA1(4), SOS1(4), STAT3(2)	30069932	54	32	52	17	12	7	7	16	11	1	0.274	1.000	1.000
413	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(2), MAPKAPK5(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CD(3), SYT1(1), TRAF2(2), TRAF3(1), TRAF5(3)	22738743	36	21	36	11	13	5	5	7	5	1	0.194	1.000	1.000
414	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(2), AXIN1(1), CCND1(4), CD14(1), CTNNB1(3), FZD1(2), GJA1(5), GNAI1(4), IRAK1(1), LBP(2), LEF1(1), NFKB1(1), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1)	20549525	36	24	36	13	11	5	7	8	5	0	0.481	1.000	1.000
415	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(2), EPX(5), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PRDX1(1), TAT(1), TPO(6)	16747382	37	21	37	13	16	8	4	6	2	1	0.227	1.000	1.000
416	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(1), GTF2H4(1), GTF2IRD1(3), STON1(2), TAF1(8), TAF10(1), TAF1L(4), TAF2(3), TAF4(3), TAF4B(3), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(2), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(1)	27486416	45	23	45	13	9	8	5	14	8	1	0.330	1.000	1.000
417	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ADC(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), ARG2(2), ASL(2), ASS1(3), CPS1(3), MAOA(2), ODC1(3), SMS(2), SRM(2)	22447678	36	19	36	12	13	4	3	8	8	0	0.461	1.000	1.000
418	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ACADM(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), MLYCD(3), SDS(1), SMS(2)	22159269	42	19	41	16	13	7	3	11	8	0	0.525	1.000	1.000
419	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(8), BRCA1(2), CDKN1A(1), CHEK1(3), CHEK2(3), MAPK8(2), MDM2(3), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(5), RBBP8(2), RELA(1)	22121685	39	19	39	12	9	7	6	11	6	0	0.430	1.000	1.000
420	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BCL2(1), BIRC2(2), CASP10(1), CASP8(2), CFLAR(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), SPTAN1(5), TNFRSF25(1), TRADD(1), TRAF2(2)	25444337	33	21	33	10	9	7	3	10	4	0	0.343	1.000	1.000
421	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(1), DERA(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKL(4), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TALDO1(2), TKT(2), TKTL2(2)	18523774	32	20	32	12	13	7	0	4	8	0	0.354	1.000	1.000
422	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), BMPR1B(1), CDK4(1), CDKN1B(3), CEBPB(1), DMC1(2), EGR1(2), ESR2(3), FSHR(2), GJA4(1), MLH1(4), NCOR1(8), NR5A1(1), NRIP1(2), PGR(4), PRLR(2), SMPD1(1), VDR(2), ZP2(4)	26759652	52	27	52	17	10	9	7	14	11	1	0.589	1.000	1.000
423	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(2), CYP11B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4)	20847939	39	28	38	15	13	4	9	11	2	0	0.435	1.000	1.000
424	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(2), EPX(5), ESCO1(1), ESCO2(2), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(6)	26102042	43	23	43	14	17	11	4	8	3	0	0.209	1.000	1.000
425	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(2), DIAPH1(5), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), TLN1(5)	25591631	34	18	34	11	10	1	8	10	4	1	0.357	1.000	1.000
426	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(7), ATP4A(5), ATP4B(2), ATP5B(2), ATP5G2(1), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), COX10(3), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B2(1), NDUFA10(3), NDUFA3(2), NDUFA7(1), NDUFA9(3), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(2), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRH(2)	42313565	75	38	74	22	15	12	14	20	13	1	0.199	1.000	1.000
427	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(5), ASH2L(2), CTCFL(4), DOT1L(3), EHMT1(5), EHMT2(3), EZH1(2), EZH2(2), FBXO11(2), HCFC1(7), HSF4(2), JMJD4(1), JMJD6(3), KDM6A(3), MEN1(1), NSD1(4), OGT(8), PAXIP1(2), PPP1CA(1), PPP1CB(1), PRDM2(6), PRDM7(2), PRDM9(8), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), RBBP5(1), SATB1(3), SETD1A(1), SETD2(12), SETD7(2), SETD8(1), SETDB1(7), SETDB2(1), SETMAR(5), STK38(1), SUV39H1(2), SUV420H1(2), SUZ12(1), WHSC1L1(4)	90481891	131	75	131	29	37	20	20	29	25	0	0.0111	1.000	1.000
428	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(2), BAX(1), BCL2(1), BIRC2(2), CASP2(1), CASP8(2), CYCS(2), FAS(1), FASLG(1), GZMB(1), MAP3K1(3), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	27856534	42	32	42	15	13	7	5	11	6	0	0.489	1.000	1.000
429	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAK1(2), BAX(1), BCL2(1), BCL2L11(1), BIRC2(2), CASP1(4), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(1), HELLS(3), IKBKB(1), IRF1(4), IRF2(1), IRF3(3), IRF4(2), IRF5(1), IRF6(2), IRF7(3), MAP3K1(3), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), NFKBIE(1), PLEKHG5(3), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TRADD(1), TRAF2(2), TRAF3(1)	42962121	77	42	77	24	27	13	5	20	12	0	0.230	1.000	1.000
430	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), DAXX(2), EGF(7), ETS1(3), FOS(1), HOXA7(2), IKBKB(1), MAP2K3(3), MAP3K1(3), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(2), PPP2CA(4), PRKCA(5), PRKCG(2), PRKCH(4), PRKCQ(2), RAF1(1), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRAF2(2)	35403747	62	37	62	21	21	12	7	9	10	3	0.167	1.000	1.000
431	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLOCK(1), CRY1(2), DNAJA1(3), EIF4G2(1), ETV6(4), HERPUD1(1), HSPA8(3), IDI1(2), KLF9(2), MYF6(2), NCKAP1(4), NCOA4(3), NR1D2(1), PER1(5), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), UGP2(1), ZFR(1)	27915352	46	22	46	15	7	9	7	19	4	0	0.545	1.000	1.000
432	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GCK(2), IL1R1(2), MAP2K5(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K9(3), MAPK10(1), MAPK7(5), MAPK8(2), MAPK9(2), MYEF2(3), NFATC3(2), NR2C2(2), PAPPA(4), SHC1(1), ZAK(2)	37779281	60	35	60	18	20	6	11	16	7	0	0.322	1.000	1.000
433	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), CREB1(1), EP300(5), EPO(1), LDHA(1), NOS3(7)	12947005	19	11	19	8	8	1	2	7	1	0	0.694	1.000	1.000
434	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), BCL2(1), IL4R(2), IRS1(4), IRS2(1), JAK1(1), JAK3(3), MAP4K1(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CD(3), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT6(4)	24919488	38	22	38	13	7	5	3	15	7	1	0.525	1.000	1.000
435	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(1), EEF2K(2), EIF2AK1(1), EIF2AK3(2), EIF2B4(1), EIF2S2(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G3(6), EIF5A(1), GSPT2(4), PABPC1(4), PABPC3(1), PAIP1(1), SLC35A4(1)	33251682	48	29	48	16	11	6	4	17	10	0	0.600	1.000	1.000
436	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(5), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1)	40091357	71	40	71	25	25	10	11	14	10	1	0.288	1.000	1.000
437	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(5), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1)	40091357	71	40	71	25	25	10	11	14	10	1	0.288	1.000	1.000
438	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(7), IL6ST(3), MRPL19(2), RPL10(4), RPL13A(1), RPL15(1), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL5(3), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(2), RPS19(1), RPS2(1), RPS24(1), RPS3(3), RPS4X(2), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), SLC36A2(1), TBC1D10C(2), UBC(5)	39869450	71	33	71	19	16	11	8	23	13	0	0.286	1.000	1.000
439	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(2), AXIN1(1), CCND1(4), CSNK1E(1), CTNNB1(3), DVL2(1), DVL3(2), FZD1(2), FZD10(2), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), MAPK10(1), MAPK9(2), PAFAH1B1(4), PLAU(1), PPP2R5C(1), PPP2R5E(2), PRKCA(5), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT5B(1), WNT7A(2)	45817464	69	41	69	23	26	5	10	12	14	2	0.246	1.000	1.000
440	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(2), ADCY8(1), ARAF(1), ATF4(1), BRAF(6), CACNA1C(2), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(2), CREBBP(9), EP300(5), GRIA1(6), GRIA2(2), GRIN1(3), GRIN2A(7), GRIN2B(6), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), RAPGEF3(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3)	75579178	158	93	157	40	46	14	24	47	24	3	0.0143	1.000	1.000
441	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(3), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HSP90AA1(1), HSP90AB1(1), IFI30(1), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL1(3), KIR2DL3(2), KIR2DL4(1), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(1), LGMN(1), NFYA(1), PSME1(3), RFX5(1), RFXANK(1), TAP1(1)	34954771	56	32	56	21	10	9	6	19	12	0	0.552	1.000	1.000
442	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(1), BCL2(1), CASP1(4), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(2), FAS(1), FASLG(1), IKBKE(5), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(3), NTRK1(3), PTPN13(3), RIPK1(3), TFG(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(1)	33086951	55	32	55	20	16	9	4	14	12	0	0.496	1.000	1.000
443	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(1), BCR(3), BLNK(2), BTK(2), CD19(1), CSK(1), DAG1(1), EPHB2(2), MAP2K2(1), MAPK1(2), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PI3(2), PIK3CD(3), PLCG2(9), PPP1R13B(1), RAF1(1), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), VAV1(5)	37258019	57	32	57	20	23	7	5	15	7	0	0.306	1.000	1.000
444	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(4), ABL2(1), AKT1(1), ARAF(1), AREG(2), BRAF(6), BTC(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(2), CDKN1A(1), CDKN1B(3), CRKL(1), EGF(7), ELK1(3), ERBB2(2), ERBB3(4), ERBB4(5), EREG(1), HBEGF(1), KRAS(3), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(2), NCK1(2), NRG1(3), NRG2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), RAF1(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(2)	73300192	148	81	146	36	40	20	20	35	31	2	0.0135	1.000	1.000
445	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(1), BIRC2(2), CASP2(1), CASP8(2), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(2), GSN(1), LMNA(2), LMNB2(2), MAP3K1(3), MAP3K5(3), MAPK8(2), MDM2(3), NFKB1(1), NFKBIA(2), NUMA1(9), PAK2(2), PRKDC(11), PTK2(2), RASA1(4), RB1(6), RELA(1), RIPK1(3), SPTAN1(5), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	52611772	88	54	88	27	23	14	14	23	13	1	0.275	1.000	1.000
446	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CANT1(3), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), NT5C(3), NT5E(1), NT5M(1), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), RRM1(3), TK2(3), UCK1(3), UMPS(1), UPP1(1)	43668317	79	43	78	26	20	14	7	27	11	0	0.461	1.000	1.000
447	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), ARHGAP5(2), BCAR1(3), BCL2(1), BIRC2(2), BRAF(6), CCND1(4), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(4), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(4), COL6A3(15), COL6A6(4), COMP(1), CRKL(1), CTNNB1(3), DIAPH1(5), DOCK1(1), EGF(7), ELK1(3), ERBB2(2), FARP2(2), FLNA(13), FLNB(9), FLNC(12), FLT1(5), FN1(6), FYN(1), HGF(3), IBSP(1), IGF1(1), IGF1R(7), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(5), ITGA7(2), ITGA8(5), ITGAV(2), ITGB1(2), ITGB3(3), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KDR(6), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(6), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(2), MET(10), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PARVA(1), PARVB(2), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRA(18), PDGFRB(1), PGF(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(5), PRKCG(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(4), RELN(12), ROCK1(2), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TLN1(5), TLN2(6), TNC(8), TNN(6), TNR(5), TNXB(11), VAV1(5), VAV2(2), VAV3(2), VCL(1), VEGFA(2), VEGFB(2), VEGFC(2), VWF(7)	277120491	548	230	542	172	163	104	71	132	73	5	0.00193	1.000	1.000
448	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(3), ACVR1C(1), AKT1(1), ARRB1(2), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), BRAF(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CACNA2D1(6), CACNA2D2(1), CACNA2D3(2), CACNA2D4(2), CACNB2(4), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(1), CACNG5(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CRKL(1), DAXX(2), DDIT3(1), DUSP1(1), DUSP10(1), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(3), DUSP7(1), DUSP9(2), EGF(7), ELK1(3), ELK4(1), FAS(1), FASLG(1), FGF13(2), FGF14(1), FGF16(1), FGF22(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(2), FGFR3(2), FGFR4(3), FLNA(13), FLNB(9), FLNC(12), FOS(1), GNG12(1), IKBKB(1), IL1B(2), IL1R1(2), IL1R2(3), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(3), MAP3K10(1), MAP3K12(5), MAP3K13(2), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(5), MKNK1(2), MRAS(1), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NTF3(1), NTRK1(3), PAK1(2), PAK2(2), PDGFA(1), PDGFRA(18), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(5), PRKCG(2), PTPN5(1), PTPN7(2), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(4), RASA1(4), RASA2(3), RASGRF1(4), RASGRF2(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA5(1), RPS6KA6(3), RRAS(1), SOS1(4), SOS2(5), SRF(2), STK3(2), STMN1(1), TAOK1(2), TAOK2(4), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TRAF2(2), ZAK(2)	209969196	427	194	422	150	124	72	55	92	80	4	0.122	1.000	1.000
449	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(4), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), C5AR1(1), CALCR(1), CCKBR(3), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CNR1(1), CNR2(2), CRHR2(3), CTSG(2), CYSLTR1(2), CYSLTR2(1), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GABBR1(2), GABBR2(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GABRB1(5), GABRB2(4), GABRB3(2), GABRD(4), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(3), GABRQ(1), GABRR1(3), GALR1(1), GH1(1), GH2(3), GHR(4), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(4), GNRHR(2), GPR156(1), GPR35(1), GPR50(2), GPR63(1), GPR83(2), GRIA1(6), GRIA2(2), GRIA3(7), GRIA4(5), GRID1(2), GRID2(3), GRIK1(4), GRIK2(3), GRIK3(2), GRIK4(5), GRIK5(3), GRIN1(3), GRIN2A(7), GRIN2B(6), GRIN2C(4), GRIN2D(4), GRIN3A(3), GRIN3B(1), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM6(3), GRM7(3), GRM8(2), GRPR(3), GZMA(1), HCRTR2(2), HRH1(3), HRH4(2), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(2), NPY1R(3), NPY2R(1), NR3C1(3), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(3), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(3), PARD3(2), PRL(1), PRLR(2), PRSS1(1), PRSS3(2), PTAFR(1), PTGER3(2), PTGER4(1), PTGFR(6), PTH2R(2), RXFP1(2), RXFP2(5), SCTR(1), SSTR2(2), SSTR3(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(3), TBXA2R(1), THRA(4), THRB(2), TRHR(2), TRPV1(2), TSHR(4), UTS2R(1), VIPR1(1), VIPR2(1)	168640945	425	194	422	134	143	74	52	107	49	0	0.00159	1.000	1.000
450	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A1(1), ATP2A2(4), ATP2A3(2), ATP2B2(4), ATP2B3(6), AVPR1A(4), AVPR1B(1), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(2), CCKBR(3), CHRM1(2), CHRM3(3), CHRM5(4), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(1), ERBB2(2), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(3), GRIN2A(7), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), GRPR(3), HRH1(3), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPR1(4), ITPR2(12), ITPR3(13), LTB4R2(1), MYLK(5), MYLK2(1), NOS1(5), NOS3(7), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(18), PDGFRB(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(5), PRKCG(2), PTAFR(1), PTGER3(2), PTGFR(6), PTK2B(2), RYR1(11), RYR3(11), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(3), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(3)	196557121	419	192	415	154	146	72	52	86	60	3	0.105	1.000	1.000
451	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(1), CHAD(1), COL11A1(7), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(4), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(4), COL6A3(15), COL6A6(4), COMP(1), DSC1(3), DSC2(2), DSC3(6), DSG1(6), DSG2(7), DSG3(2), DSG4(2), FN1(6), GJA1(5), GJA10(1), GJA3(1), GJA4(1), GJA8(1), GJB2(1), GJB4(1), GJB6(2), GJC3(1), GJD4(1), IBSP(1), INA(1), ITGA6(5), ITGB4(5), KRT1(3), KRT12(1), KRT13(3), KRT14(1), KRT16(3), KRT18(1), KRT19(1), KRT2(2), KRT20(3), KRT23(1), KRT24(2), KRT25(2), KRT27(2), KRT28(5), KRT3(4), KRT31(3), KRT33A(5), KRT33B(2), KRT34(2), KRT35(3), KRT36(4), KRT37(3), KRT39(2), KRT40(1), KRT5(4), KRT6A(2), KRT6B(4), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT75(4), KRT76(1), KRT77(1), KRT78(2), KRT79(3), KRT8(4), KRT81(3), KRT82(1), KRT83(4), KRT84(3), KRT86(3), KRT9(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(6), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), LMNA(2), LMNB2(2), NES(2), PRPH(1), RELN(12), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VIM(2), VWF(7)	188968774	409	187	404	148	147	94	37	91	38	2	0.0648	1.000	1.000
452	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(2), ACTN1(1), ACTN2(6), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(3), ARHGEF4(4), ARHGEF6(5), ARPC1A(2), ARPC1B(1), ARPC3(1), BAIAP2(3), BCAR1(3), BRAF(6), CD14(1), CFL1(1), CFL2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(4), DIAPH1(5), DIAPH2(2), DIAPH3(2), DOCK1(1), EGF(7), F2(3), F2R(2), FGD1(1), FGD3(2), FGF13(2), FGF14(1), FGF16(1), FGF22(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(2), FGFR3(2), FGFR4(3), FN1(6), GIT1(2), GNA13(1), GNG12(1), GSN(1), IQGAP1(9), IQGAP2(5), IQGAP3(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(5), ITGA7(2), ITGA8(5), ITGAD(2), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(2), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(3), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KRAS(3), LIMK1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MRAS(1), MSN(1), MYH10(7), MYH14(4), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), NCKAP1(4), NCKAP1L(3), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PDGFA(1), PDGFRA(18), PDGFRB(1), PFN4(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(4), RRAS(1), SCIN(2), SOS1(4), SOS2(5), SSH1(2), SSH2(1), SSH3(2), TIAM1(5), TIAM2(9), VAV1(5), VAV2(2), VAV3(2), VCL(1), WAS(2), WASF1(1), WASF2(1), WASL(2)	205265040	366	170	363	128	90	62	52	100	60	2	0.197	1.000	1.000
453	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(4), ABLIM1(3), ABLIM2(2), ABLIM3(5), ARHGEF12(3), CFL1(1), CFL2(1), CXCR4(2), DCC(6), EFNA1(1), EFNA3(3), EFNA5(1), EFNB1(2), EFNB2(1), EFNB3(1), EPHA2(2), EPHA3(7), EPHA4(7), EPHA5(5), EPHA6(1), EPHA7(5), EPHA8(6), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(4), EPHB6(6), FES(5), FYN(1), GNAI1(4), GNAI2(1), GNAI3(2), ITGB1(2), KRAS(3), L1CAM(7), LIMK1(4), LRRC4C(4), MAPK1(2), MAPK3(1), MET(10), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NGEF(6), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PLXNA1(10), PLXNA2(6), PLXNA3(6), PLXNB1(6), PLXNB2(3), PLXNB3(8), PLXNC1(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(9), RHOD(1), RND1(1), ROBO1(4), ROBO2(9), ROBO3(5), ROCK1(2), ROCK2(4), SEMA3A(5), SEMA3C(1), SEMA3D(3), SEMA3E(6), SEMA3F(2), SEMA4A(2), SEMA4B(2), SEMA4D(2), SEMA4F(3), SEMA4G(3), SEMA5B(1), SEMA6A(3), SEMA6B(4), SEMA6C(2), SEMA6D(5), SEMA7A(3), SLIT1(6), SLIT2(5), SLIT3(2), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(2), UNC5D(1)	150137199	335	151	333	105	99	50	46	89	50	1	0.0275	1.000	1.000
454	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1(3), ACVR1B(3), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(1), CCL1(1), CCL11(2), CCL16(1), CCL20(1), CCL26(2), CCL27(1), CCL5(1), CCR2(2), CCR3(1), CCR4(1), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(4), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL13(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDA2R(1), EDAR(6), EGF(7), EPO(1), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(4), FLT4(6), GDF5(1), GH1(1), GH2(3), GHR(4), HGF(3), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL17B(1), IL17RA(1), IL17RB(1), IL18(3), IL18R1(2), IL18RAP(3), IL19(1), IL1B(2), IL1R1(2), IL1R2(3), IL1RAP(1), IL20RA(3), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(1), IL9(1), IL9R(3), INHBB(1), INHBE(2), KDR(6), KIT(6), KITLG(2), LEPR(2), LIFR(2), LTB(1), LTBR(2), MET(10), MPL(2), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(18), PDGFRB(1), PLEKHO2(1), PPBP(1), PRL(1), PRLR(2), RELT(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TNFRSF6B(1), TNFRSF8(2), TNFRSF9(3), TNFSF13B(1), TNFSF15(3), TNFSF8(2), TNFSF9(2), TPO(6), VEGFA(2), VEGFB(2), VEGFC(2), XCL1(1)	131630587	299	146	295	106	69	62	51	75	42	0	0.154	1.000	1.000
455	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(4), CD44(3), CHAD(1), COL11A1(7), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(4), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(4), COL6A3(15), COL6A6(4), DAG1(1), FN1(6), FNDC1(4), FNDC3A(5), FNDC5(1), GP5(2), GP6(1), GP9(1), HMMR(1), HSPG2(16), IBSP(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(5), ITGA7(2), ITGA8(5), ITGAV(2), ITGB1(2), ITGB3(3), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(6), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), RELN(12), SDC1(1), SDC3(1), SPP1(2), SV2A(2), SV2B(3), SV2C(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VWF(7)	170265532	333	145	331	102	107	78	38	72	36	2	0.00373	1.000	1.000
456	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), AMOTL1(4), ASH1L(5), CASK(2), CDK4(1), CGN(1), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTTN(1), EPB41L1(2), EPB41L2(7), EPB41L3(7), EXOC3(1), EXOC4(3), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(1), INADL(5), JAM2(4), JAM3(2), KRAS(3), LLGL1(3), LLGL2(3), MAGI1(4), MAGI2(4), MAGI3(5), MLLT4(7), MPDZ(10), MRAS(1), MYH1(12), MYH10(7), MYH11(9), MYH13(11), MYH14(4), MYH15(7), MYH3(9), MYH6(5), MYH7(11), MYH7B(9), MYL2(2), MYL5(1), OCLN(2), PARD3(2), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(2), RAB3B(1), RRAS(1), SPTAN1(5), SYMPK(3), TJAP1(1), TJP1(5), TJP2(1), TJP3(3), YES1(2), ZAK(2)	137676951	285	145	284	87	103	39	38	67	36	2	0.0312	1.000	1.000
457	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(1), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(2), ATP2B2(4), ATP2B3(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1S(7), CACNB3(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(2), CASQ1(2), CASQ2(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB4(1), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(3), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), ITPR1(4), ITPR2(12), ITPR3(13), KCNB1(3), KCNJ3(1), KCNJ5(3), MIB1(1), MYCBP(1), PEA15(1), PKIB(1), PLCB3(4), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(4), PRKCQ(2), RGS11(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(1), RYR1(11), RYR3(11), SFN(2), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1)	136109821	263	119	262	98	94	41	38	47	40	3	0.226	1.000	1.000
458	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(3), CD22(4), CD226(1), CD274(1), CD276(1), CD28(1), CD34(1), CD4(1), CD40(1), CD40LG(2), CD58(1), CD86(1), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(6), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(2), CNTN2(2), CNTNAP1(4), CNTNAP2(4), CTLA4(1), ESAM(1), F11R(1), GLG1(2), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), ICAM1(2), ICAM2(1), ICOS(1), ICOSLG(2), ITGA4(5), ITGA6(5), ITGA8(5), ITGAL(2), ITGAM(2), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(4), JAM3(2), L1CAM(7), MAG(2), MPZ(2), NCAM1(2), NEGR1(3), NEO1(8), NFASC(1), NLGN1(3), NLGN2(4), NLGN3(4), NRCAM(6), NRXN1(5), NRXN3(5), OCLN(2), PDCD1LG2(1), PTPRC(7), PTPRF(5), PTPRM(7), PVR(2), PVRL1(1), PVRL3(2), SDC1(1), SDC3(1), SELE(6), SELP(2), SELPLG(1), SIGLEC1(4), SPN(1), VCAM1(1), VCAN(7)	112548450	233	117	230	84	64	49	23	57	40	0	0.175	1.000	1.000
459	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADK(1), ADSL(4), ADSSL1(1), AK5(2), AK7(4), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), CANT1(3), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), GART(4), GDA(1), GMPR(1), GMPR2(2), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(3), IMPDH2(1), NPR1(1), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), PAICS(2), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE2A(4), PDE4A(1), PDE4B(1), PDE4C(3), PDE4D(8), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PDE9A(2), PFAS(6), PKLR(3), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(1), PRIM2(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3), RRM2B(1), XDH(8)	124440620	229	115	228	79	66	41	25	62	35	0	0.225	1.000	1.000
460	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA2(2), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ARRB1(2), ARRB2(1), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(2), CACNB3(2), CALCA(1), CALM3(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(3), CREB3(3), DGKZ(1), FOS(1), GABPA(2), GBA2(1), GJA1(5), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), GUCY1A3(2), IGFBP2(1), IGFBP6(1), IL1B(2), IL6(1), ITPR1(4), ITPR2(12), ITPR3(13), MIB1(1), MYL2(2), MYLK2(1), NFKB1(1), NOS1(5), NOS3(7), PDE4B(1), PDE4D(8), PKIB(1), PLCB3(4), PLCD1(1), PLCG1(6), PLCG2(9), PRKAR1A(2), PRKCA(5), PRKCH(4), PRKCQ(2), RAMP3(1), RGS11(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(1), RLN1(1), RYR1(11), RYR3(11), SFN(2), SLC8A1(3), TNXB(11), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1)	125075276	246	115	244	95	81	34	37	54	37	3	0.437	1.000	1.000
461	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA2(2), ACTN2(6), ACTN4(2), DMD(12), MYBPC1(4), MYBPC2(4), MYH3(9), MYH6(5), MYH7(11), MYL1(2), MYL2(2), MYOM1(3), NEB(20), TNNI1(1), TNNT1(1), TNNT3(4), TPM1(6), TPM2(1), TPM3(2), TPM4(1), TTN(132), VIM(2)	100691208	232	113	231	71	67	42	28	71	22	2	0.115	1.000	1.000
462	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), CSNK1D(1), EGF(7), GJA1(5), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HTR2A(1), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K5(2), MAPK1(2), MAPK3(1), MAPK7(5), NPR1(1), NPR2(3), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRA(18), PDGFRB(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), SOS1(4), SOS2(5), TJP1(5), TUBA1A(2), TUBA3C(5), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3)	98636463	202	112	200	71	63	30	28	44	34	3	0.275	1.000	1.000
463	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(2), AXIN1(1), AXIN2(1), BTRC(1), CACYBP(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CCND1(4), CHD8(2), CREBBP(9), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CSNK2B(1), CTBP1(5), CTBP2(1), CTNNB1(3), CUL1(1), CXXC4(1), DAAM1(1), DAAM2(2), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(2), EP300(5), FZD1(2), FZD10(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), LEF1(1), LRP5(7), LRP6(7), MAPK10(1), MAPK8(2), MAPK9(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NKD1(1), NKD2(4), NLK(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PORCN(5), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(5), PRKCG(2), RAC1(1), RAC2(1), RBX1(1), ROCK1(2), ROCK2(4), RUVBL1(1), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SOX17(3), TBL1XR1(3), TBL1Y(1), TCF7L2(4), VANGL1(1), VANGL2(2), WIF1(2), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1)	122760269	228	108	227	73	72	30	28	57	40	1	0.130	1.000	1.000
464	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(5), AMY2B(3), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHX58(1), ENPP1(4), ENPP3(2), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), G6PC2(1), GAA(5), GANC(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), IFIH1(3), LYZL1(1), MGAM(9), MOV10L1(3), PGM3(1), PYGB(1), PYGL(5), PYGM(1), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SI(9), SKIV2L2(3), SMARCA2(2), SMARCA5(2), TREH(1), UGDH(1), UGP2(1), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2), UXS1(2)	93732309	190	103	189	48	56	34	26	51	23	0	0.00832	1.000	1.000
465	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	146	AKT1(1), CBL(1), CBLB(2), CBLC(2), CCND1(4), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(9), CRLF2(3), CSF2RB(2), CSF3R(2), EP300(5), EPO(1), EPOR(1), GH1(1), GH2(3), GHR(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL19(1), IL20RA(3), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(1), IL9(1), IL9R(3), IRF9(7), JAK1(1), JAK2(4), JAK3(3), LEPR(2), LIFR(2), MPL(2), OSMR(3), PIAS1(1), PIAS3(2), PIAS4(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRL(1), PRLR(2), PTPN11(7), SOCS4(2), SOCS5(2), SOS1(4), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3), STAM(2), STAM2(1), STAT1(2), STAT2(1), STAT3(2), STAT4(2), STAT5A(1), STAT5B(2), STAT6(4), TPO(6), TYK2(7)	106806342	215	103	213	61	49	31	32	75	27	1	0.0453	1.000	1.000
466	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(1), BRAF(6), CACNA1A(3), GNA11(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(3), GNAS(4), GNAZ(1), GRIA1(6), GRIA2(2), GRIA3(7), GRID2(3), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), IGF1(1), IGF1R(7), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(5), NOS3(7), NPR1(1), NPR2(3), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), RYR1(11)	83680826	185	103	184	51	45	24	36	45	32	3	0.0381	1.000	1.000
467	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(12), ACACB(11), AKT1(1), ARAF(1), BRAF(6), CALM3(1), CALML3(1), CALML6(1), CBL(1), CBLB(2), CBLC(2), CRKL(1), ELK1(3), EXOC7(1), FASN(3), FBP1(1), FBP2(1), FLOT1(1), FLOT2(3), G6PC2(1), GCK(2), GYS1(1), GYS2(2), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS2(1), IRS4(5), KRAS(3), LIPE(3), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(2), MKNK1(2), PCK1(3), PDE3A(2), PFKL(4), PFKP(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(3), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAG3(1), PRKAR1A(2), PRKCI(2), PTPN1(1), PTPRF(5), PYGB(1), PYGL(5), PYGM(1), RAF1(1), RAPGEF1(4), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SLC2A4(1), SOCS4(2), SORBS1(1), SOS1(4), SOS2(5), SREBF1(6), TSC1(2), TSC2(3)	118415906	206	102	205	76	56	34	26	57	30	3	0.358	1.000	1.000
468	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR4(1), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CHML(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(2), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GPR17(1), GPR173(1), GPR174(1), GPR35(1), GPR37(3), GPR37L1(1), GPR4(1), GPR50(2), GPR6(2), GPR63(1), GPR83(2), GPR85(2), GPR87(1), GRPR(3), HCRTR2(2), HRH1(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LTB4R(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPY1R(3), NPY2R(1), NTSR1(1), OPN1SW(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(3), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(3), OR7C1(1), P2RY1(1), P2RY12(2), P2RY13(1), P2RY2(2), P2RY6(2), PTAFR(1), PTGER4(1), PTGFR(6), RRH(1), SSTR2(2), SSTR3(5), SUCNR1(2), TBXA2R(1), TRHR(2)	92247392	203	101	202	78	74	32	30	52	15	0	0.137	1.000	1.000
469	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(4), ANAPC1(2), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC5(5), ANAPC7(1), ATM(8), ATR(6), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC27(4), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CHEK1(3), CHEK2(3), CREBBP(9), CUL1(1), DBF4(5), E2F1(1), E2F2(1), E2F3(1), EP300(5), ESPL1(5), FZR1(3), HDAC2(4), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(11), RB1(6), RBL1(4), RBL2(3), RBX1(1), SFN(2), SKP2(3), SMAD2(3), SMAD3(3), SMC1A(5), SMC1B(7), TGFB2(2), TGFB3(1), WEE1(1), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	102841445	208	99	208	54	36	35	36	56	42	3	0.0411	1.000	1.000
470	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(1), BRAF(6), CD244(1), FAS(1), FASLG(1), FCGR3A(1), FCGR3B(1), FYN(1), GZMB(1), HLA-A(1), HLA-C(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(1), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(3), KIR2DL3(2), KIR2DL4(1), KIR3DL1(1), KLRC1(2), KLRC2(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MAP2K2(1), MAPK1(2), MAPK3(1), MICA(4), MICB(1), NCR1(1), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PAK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRF1(3), PRKCA(5), PRKCG(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAF1(1), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(4), VAV1(5), VAV2(2), VAV3(2), ZAP70(5)	82965214	171	99	167	58	43	26	18	52	30	2	0.203	1.000	1.000
471	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ASIP(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3(3), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREBBP(9), CTNNB1(3), DVL2(1), DVL3(2), EDNRB(1), EP300(5), FZD1(2), FZD10(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(3), GNAS(4), KIT(6), KITLG(2), KRAS(3), LEF1(1), MAP2K2(1), MAPK1(2), MAPK3(1), MC1R(3), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), TCF7L2(4), TYR(4), TYRP1(4), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1)	82888485	164	96	163	54	57	12	21	39	33	2	0.237	1.000	1.000
472	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), INPP4A(1), INPP4B(4), INPP5B(3), INPP5D(2), INPPL1(5), ITPK1(3), ITPR1(4), ITPR2(12), ITPR3(13), OCRL(5), PI4KA(7), PI4KB(2), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3C3(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(4), PRKCA(5), PRKCG(2), PTPMT1(1), SYNJ1(6), SYNJ2(9)	91430461	179	94	178	58	55	32	22	43	25	2	0.147	1.000	1.000
473	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(1), ACTN2(6), ACTN4(2), ARHGAP5(2), BCAR1(3), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(1), ESAM(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(7), MMP9(2), MSN(1), MYL2(2), MYL5(1), NCF1(2), NCF2(3), NCF4(1), NOX1(1), NOX3(1), OCLN(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(4), SIPA1(2), TXK(1), VAV1(5), VAV2(2), VAV3(2), VCAM1(1), VCL(1)	91838319	171	94	168	74	54	26	23	44	23	1	0.734	1.000	1.000
474	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ATF4(1), CACNA1C(2), CACNA1D(7), CACNA1F(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), ELK1(3), GNA11(1), GNAS(4), GNRHR(2), HBEGF(1), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAP3K3(2), MAP3K4(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK9(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLD1(7), PRKACG(1), PRKCA(5), PTK2B(2), RAF1(1), SOS1(4), SOS2(5)	94706687	181	94	181	65	65	23	28	36	26	3	0.200	1.000	1.000
475	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(5), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(13), C3AR1(3), C4BPA(6), C4BPB(1), C5(6), C5AR1(1), C6(3), C7(5), C8A(2), C8B(4), CD46(3), CD55(1), CFB(4), CFD(1), CFH(8), CPB2(1), CR1(5), CR2(4), F10(1), F12(1), F13A1(2), F13B(4), F2(3), F2R(2), F5(7), F7(2), F8(18), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), KNG1(2), MASP1(2), MBL2(3), PLAT(1), PLAU(1), PLG(4), PROS1(1), SERPINA5(1), SERPINC1(1), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(3), VWF(7)	68950664	171	93	171	54	53	29	21	45	23	0	0.0772	1.000	1.000
476	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN4(2), ACVR1B(3), ACVR1C(1), BAIAP2(3), CDH1(4), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), EP300(5), ERBB2(2), FARP2(2), FER(1), FGFR1(2), FYN(1), IGF1R(7), INSR(4), IQGAP1(9), LEF1(1), LMO7(6), MAPK1(2), MAPK3(1), MET(10), MLLT4(7), NLK(1), PARD3(2), PTPN1(1), PTPRB(6), PTPRF(5), PTPRJ(4), PTPRM(7), PVRL1(1), PVRL3(2), PVRL4(1), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SORBS1(1), SSX2IP(1), TCF7L2(4), TGFBR1(2), TGFBR2(3), TJP1(5), VCL(1), WAS(2), WASF1(1), WASF2(1), WASF3(3), WASL(2), YES1(2)	89281653	172	92	172	47	55	18	22	44	32	1	0.0253	1.000	1.000
477	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADK(1), ADSL(4), AK5(2), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), ATP1B1(1), ATP5B(2), ATP5G2(1), CANT1(3), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), GART(4), GDA(1), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(3), IMPDH2(1), NPR1(1), NPR2(3), NT5C(3), NT5E(1), NT5M(1), PAICS(2), PDE1A(1), PDE4A(1), PDE4B(1), PDE4C(3), PDE4D(8), PDE5A(1), PDE6B(3), PDE6C(7), PDE7B(2), PDE8A(6), PDE9A(2), PFAS(6), PKLR(3), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3)	97777520	178	92	178	71	55	35	18	46	24	0	0.593	1.000	1.000
478	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), AKAP1(1), AKAP11(2), AKAP12(1), AKAP3(2), AKAP4(6), AKAP5(2), AKAP6(9), AKAP7(2), AKAP8(4), AKAP9(10), ARHGEF1(1), CALM3(1), GNA11(1), GNA13(1), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(3), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), ITPR1(4), KCNJ3(1), KRAS(3), PALM2(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4B(1), PDE4C(3), PDE4D(8), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(2), RRAS(1), USP5(1)	88902355	152	89	152	60	42	22	16	37	33	2	0.636	1.000	1.000
479	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(3), B3GNT2(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(3), CHST13(2), CHST3(3), CHST4(1), CHSY1(2), DAD1(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), FUT8(6), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT5(3), GALNT6(3), GALNT8(1), GALNT9(2), GALNTL5(1), GANAB(5), GCNT3(1), GCNT4(2), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(2), NDST1(2), NDST2(2), NDST3(3), NDST4(2), OGT(8), RPN1(1), RPN2(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(1), ST6GALNAC1(2), STT3B(2), WBSCR17(5), XYLT1(2), XYLT2(1)	84081651	156	87	155	52	52	29	20	34	21	0	0.200	1.000	1.000
480	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGEF6(5), BCAR1(3), BRAF(6), CDKN2A(4), DOCK1(1), EPHB2(2), FYN(1), GRB7(6), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA4(5), ITGA5(2), ITGA6(5), ITGA7(2), ITGA8(5), MAP3K11(1), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(2), MRAS(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PIK3CB(3), PKLR(3), PLCG1(6), PLCG2(9), PTK2(2), RAF1(1), RALA(2), ROCK1(2), ROCK2(4), SHC1(1), SOS1(4), SOS2(5), TERF2IP(1), TLN1(5), TLN2(6), WAS(2)	90857460	164	86	161	43	45	26	21	48	24	0	0.0175	1.000	1.000
481	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(3), ACVR1B(3), ACVRL1(5), AKT1(1), BMPR1A(1), BUB1(4), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(2), CSNK2B(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), INPP4A(1), INPP4B(4), INPPL1(5), MAP3K10(1), NEK1(2), NEK3(2), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(5), PIM2(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9), PLK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(4), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), STK11(1), TGFBR1(2), VRK1(3)	84173034	149	85	148	54	46	23	18	34	25	3	0.477	1.000	1.000
482	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(1), ABCA12(4), ABCA13(17), ABCA2(4), ABCA3(4), ABCA4(7), ABCA5(4), ABCA6(6), ABCA7(9), ABCA8(5), ABCA9(3), ABCB1(5), ABCB10(3), ABCB11(1), ABCB4(6), ABCB5(6), ABCB7(5), ABCB8(1), ABCB9(2), ABCC1(5), ABCC10(11), ABCC11(7), ABCC12(4), ABCC2(1), ABCC3(5), ABCC4(4), ABCC5(3), ABCC6(1), ABCC8(6), ABCC9(6), ABCD1(2), ABCD2(1), ABCG1(1), ABCG2(1), ABCG4(3), ABCG5(3), ABCG8(4), CFTR(4), TAP1(1)	89939375	172	79	172	68	46	28	27	50	18	3	0.555	1.000	1.000
483	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), BCAR1(3), CAPN10(4), CAPN11(4), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(4), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ILK(1), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(5), ITGA7(2), ITGA8(5), ITGAD(2), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(2), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(3), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(3), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PIK3R2(1), PTK2(2), RAC1(1), RAC2(1), RAPGEF1(4), ROCK1(2), ROCK2(4), SDCCAG8(2), SEPP1(2), SHC1(1), SHC3(1), SORBS1(1), SOS1(4), TLN1(5), TNS1(3), VAV2(2), VAV3(2), VCL(1)	101991591	162	76	162	56	49	24	23	42	24	0	0.269	1.000	1.000
484	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(1), CASP8(2), CCL5(1), CD14(1), CD40(1), CD86(1), CXCL9(1), FOS(1), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(1), IKBKB(1), IKBKE(5), IL12B(2), IL1B(2), IL6(1), IRAK1(1), IRAK4(2), IRF3(3), IRF5(1), IRF7(3), LBP(2), MAP2K2(1), MAP2K3(3), MAP3K8(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(3), SPP1(2), STAT1(2), TBK1(2), TICAM1(1), TLR1(4), TLR2(1), TLR3(5), TLR4(2), TLR5(2), TLR6(3), TLR7(6), TLR9(3), TNF(1), TOLLIP(1), TRAF3(1)	65242980	119	72	118	44	32	24	16	30	15	2	0.288	1.000	1.000
485	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(1), CARD11(3), CBL(1), CBLB(2), CBLC(2), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FOS(1), FYN(1), GRAP2(1), ICOS(1), IKBKB(1), IL10(1), IL5(1), ITK(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MALT1(2), MAP3K8(4), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(7), RASGRP1(1), SOS1(4), SOS2(5), TEC(3), TNF(1), VAV1(5), VAV2(2), VAV3(2), ZAP70(5)	74137385	137	72	136	45	37	26	15	37	21	1	0.233	1.000	1.000
486	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(2), CPSF2(2), CPSF3(3), CSTF1(2), CSTF2(3), CSTF3(4), DDIT3(1), DHX15(1), DHX16(4), DHX38(3), DHX8(7), DHX9(2), DICER1(2), FUS(3), METTL3(4), NCBP1(1), NONO(2), PAPOLA(5), PHF5A(2), POLR2A(7), PRPF18(1), PRPF4(1), PRPF4B(3), PRPF8(10), PSKH1(1), PTBP1(2), RNGTT(4), SF3A3(1), SF3B1(7), SF3B2(1), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNRPF(1), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(3)	80549010	133	72	132	31	40	19	15	39	19	1	0.0585	1.000	1.000
487	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(3), ACVR1B(3), ACVR1C(1), ACVR2A(2), ACVRL1(5), AMHR2(1), BMP4(2), BMP5(4), BMP6(2), BMPR1A(1), BMPR1B(1), CHRD(1), COMP(1), CREBBP(9), CUL1(1), DCN(2), E2F5(1), EP300(5), FST(1), GDF5(1), GDF6(1), GDF7(1), INHBB(1), INHBE(2), LEFTY2(2), LTBP1(7), MAPK1(2), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), RBL1(4), RBL2(3), RBX1(1), ROCK1(2), ROCK2(4), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD5(1), SMAD6(1), SMAD7(2), SMAD9(3), SMURF1(2), SMURF2(2), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNF(1), ZFYVE16(1), ZFYVE9(1)	75697233	150	70	150	41	45	21	24	39	20	1	0.0311	1.000	1.000
488	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(2), BRAF(6), CREB1(1), DAXX(2), ELK1(3), FOS(1), IKBKB(1), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP3K9(3), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAP4K5(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(2), MAPK7(5), MAPK8(2), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(5), MEF2A(2), MEF2B(1), MKNK1(2), NFKB1(1), NFKBIA(2), PAK1(2), PAK2(2), RAC1(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA5(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	72344165	129	70	126	43	34	14	22	29	28	2	0.323	1.000	1.000
489	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(3), CD14(1), CD19(1), CD1A(3), CD1B(4), CD1E(4), CD22(4), CD33(1), CD34(1), CD36(4), CD3D(1), CD4(1), CD44(3), CD55(1), CD7(1), CR1(5), CR2(4), CSF1R(4), CSF3R(2), DNTT(1), EPO(1), EPOR(1), FCGR1A(1), FLT3(4), GP5(2), GP9(1), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), IL1B(2), IL1R1(2), IL1R2(3), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL7R(1), IL9R(3), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(5), ITGAM(2), ITGB3(3), KIT(6), KITLG(2), MME(2), MS4A1(3), TFRC(2), THPO(1), TNF(1), TPO(6)	61286315	132	67	132	41	32	30	20	35	15	0	0.0582	1.000	1.000
490	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(4), ATM(8), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), DTX4(2), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(5), ESPL1(5), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MPEG1(2), MPL(2), PLK1(2), PRKDC(11), PTPRA(4), RB1(6), RBL1(4), SKP2(3), TBC1D8(1), WEE1(1)	82934185	146	65	146	48	27	27	20	39	30	3	0.383	1.000	1.000
491	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(1), CELSR1(9), CELSR2(12), CELSR3(12), CHRM3(3), EDNRA(1), EMR2(5), EMR3(1), F2R(2), FSHR(2), GHRHR(2), GNRHR(2), GPR116(6), GPR132(5), GPR133(4), GPR143(4), GPR17(1), GPR18(2), GPR61(3), GPR84(2), GRM1(4), GRPR(3), HRH4(2), LPHN2(7), LPHN3(5), LTB4R2(1), NTSR1(1), P2RY13(1), PTGFR(6), SMO(2), SSTR2(2), TAAR5(1), TSHR(4)	50799301	128	64	127	40	42	27	18	30	11	0	0.0363	1.000	1.000
492	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP4A(1), INPP4B(4), INPP5B(3), INPPL1(5), IPMK(2), ISYNA1(2), ITPK1(3), MINPP1(1), OCRL(5), PI4KA(7), PI4KB(2), PIK3C3(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(4), PTPMT1(1), SYNJ1(6), SYNJ2(9)	54386628	114	63	113	35	31	22	12	32	17	0	0.195	1.000	1.000
493	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(1), AKR1C2(1), AKR1C3(1), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), CYP1A2(2), CYP1B1(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2S1(1), CYP3A4(3), CYP3A7(1), EPHX1(3), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(6), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(1), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2)	43714439	109	63	108	34	31	14	18	34	12	0	0.202	1.000	1.000
494	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(8), CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CREB3(3), CREB3L1(1), CREB3L3(1), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MYT1(7), NACA(5), POLA2(1), POLE(8), PRIM1(1), RB1(6), RBL1(4), RPA1(3), TNXB(11), WEE1(1)	58225259	108	62	108	33	19	9	15	27	38	0	0.437	1.000	1.000
495	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BCL2(1), CABIN1(6), CALM3(1), CAMK4(2), CDKN1A(1), CEBPB(1), CNR1(1), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTLA4(1), EGR3(1), EP300(5), FCER1A(2), FCGR3A(1), FOS(1), GATA3(3), GATA4(1), ICOS(1), IFNB1(1), IL10(1), IL1B(2), IL3(1), IL6(1), ITK(1), KPNA5(3), MAPK8(2), MAPK9(2), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB2(1), NFKBIE(1), NUP214(2), OPRD1(1), P2RX7(1), PAK1(2), PPP3CB(1), PPP3CC(1), PTPRC(7), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(4), TNF(1), TRAF2(2), TRPV6(7), VAV1(5), VAV2(2), VAV3(2), XPO5(1)	69330577	126	61	126	38	32	28	14	32	20	0	0.0801	1.000	1.000
496	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(5), CANT1(3), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(1), RRM1(3), RRM2B(1), TK2(3), TXNRD2(4), UCK1(3), UMPS(1), UPP1(1), UPP2(2), UPRT(2)	61634891	114	61	113	35	24	16	13	39	22	0	0.334	1.000	1.000
497	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(11), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(1), CAMKK1(1), CAMKK2(2), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), G6PC2(1), IKBKB(1), IRS1(4), IRS2(1), IRS4(5), JAK1(1), JAK2(4), JAK3(3), LEPR(2), MAPK10(1), MAPK8(2), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NPY(3), PCK1(3), PPARA(3), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(7), RELA(1), RXRA(1), RXRB(1), RXRG(3), SLC2A1(2), SLC2A4(1), STAT3(2), STK11(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(7)	62656245	124	61	122	47	33	24	8	38	20	1	0.466	1.000	1.000
498	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(5), ADCY8(1), CACNA1A(3), CACNA1B(9), GNAS(4), GNAT3(1), GNB3(1), GRM4(4), ITPR3(13), KCNB1(3), PDE1A(1), PLCB2(4), PRKACG(1), SCNN1B(3), SCNN1G(2), TAS1R2(3), TAS1R3(1), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R16(4), TAS2R3(1), TAS2R38(1), TAS2R4(2), TAS2R40(2), TAS2R41(3), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R7(1), TAS2R9(4), TRPM5(3)	43337612	89	60	89	30	35	15	9	21	9	0	0.245	1.000	1.000
499	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), BCL2(1), BCR(3), BLNK(2), BTK(2), CD19(1), CD22(4), CD81(2), CR2(4), CSK(1), DAG1(1), FLOT1(1), FLOT2(3), INPP5D(2), ITPR1(4), ITPR2(12), ITPR3(13), MAP4K1(1), MAPK1(2), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(2), PIK3CD(3), PLCG2(9), PPP1R13B(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPRC(7), RAF1(1), SHC1(1), SOS1(4), SOS2(5), VAV1(5)	53451091	109	60	109	33	36	16	12	33	10	2	0.0890	1.000	1.000
500	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(1), BTK(2), FCER1A(2), FYN(1), GAB2(2), IL3(1), IL5(1), INPP5D(2), KRAS(3), LAT(2), LCP2(1), MAP2K2(1), MAP2K3(3), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(2), PDK1(2), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PRKCA(5), RAC1(1), RAC2(1), RAF1(1), SOS1(4), SOS2(5), TNF(1), VAV1(5), VAV2(2), VAV3(2)	51796492	104	58	103	33	30	18	14	26	14	2	0.159	1.000	1.000
501	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(3), ATP8A1(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR4(1), CCR6(2), CCR7(1), CCR8(1), CX3CR1(1), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GNRHR(2), GRPR(3), MC1R(3), MC3R(2), MC4R(3), MC5R(3), NMBR(5), NPY1R(3), NPY2R(1), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(3), SSTR2(2), SSTR3(5), TACR2(2), TACR3(3), TRHR(2), TSHR(4)	39404011	92	56	92	47	30	11	21	24	6	0	0.862	1.000	1.000
502	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	CREBBP(9), CTBP1(5), CTBP2(1), DLL3(1), DTX1(4), DTX3L(1), DTX4(2), DVL2(1), DVL3(2), EP300(5), HDAC2(4), JAG1(4), JAG2(1), LFNG(2), MAML1(4), MAML2(2), MAML3(4), MFNG(1), NCOR2(7), NCSTN(4), NOTCH2(11), NOTCH3(6), NOTCH4(8), NUMB(1), NUMBL(2), RBPJL(2), SNW1(3)	48802232	97	55	97	36	31	13	9	20	23	1	0.599	1.000	1.000
503	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(1), KDR(6), KRAS(3), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NOS3(7), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKCA(5), PRKCG(2), PTGS2(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2)	51667398	105	55	104	35	31	14	18	25	15	2	0.187	1.000	1.000
504	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(2), ARHGEF11(2), BTK(2), CFL1(1), CFL2(1), GDI1(3), GDI2(1), INPPL1(5), ITPR1(4), ITPR2(12), ITPR3(13), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CD(3), PIK3CG(5), PITX2(4), PPP1R13B(1), ROCK1(2), ROCK2(4), RPS4X(2), SAG(2), WASF1(1), WASL(2)	49966134	106	53	106	30	27	20	20	30	8	1	0.0784	1.000	1.000
505	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACADM(2), ACOX1(2), ACOX2(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ANGPTL4(1), APOA1(1), AQP7(3), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(1), CYP4A22(2), CYP7A1(2), CYP8B1(1), DBI(1), EHHADH(1), FABP4(1), FABP6(1), FABP7(1), FADS2(2), GK(1), GK2(4), HMGCS2(3), ILK(1), LPL(2), ME1(1), MMP1(1), NR1H3(5), OLR1(1), PCK1(3), PPARA(3), PPARG(2), RXRA(1), RXRB(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(4), SORBS1(1), UBC(5)	49826175	98	52	97	36	23	21	12	28	14	0	0.377	1.000	1.000
506	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(4), AKT1(1), APAF1(3), ATM(8), BAX(1), BCL2(1), BIRC2(2), CASP10(1), CASP8(2), CFLAR(1), CSF2RB(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(1), IRAK2(2), IRAK3(6), IRAK4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(3), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKAR1A(2), RELA(1), RIPK1(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TRADD(1), TRAF2(2)	60161328	90	52	90	34	19	14	10	30	17	0	0.710	1.000	1.000
507	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(1), BLNK(2), BTK(2), CARD11(3), CD19(1), CD22(4), CD72(3), CD79A(1), CD81(2), CR2(4), FOS(1), IFITM1(1), IKBKB(1), INPP5D(2), KRAS(3), LILRB3(2), MALT1(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CB(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(5), VAV2(2), VAV3(2)	53447247	95	49	95	37	34	19	4	23	15	0	0.418	1.000	1.000
508	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(1), ACAT2(1), ACMSD(1), AFMID(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), AOX1(5), ASMT(1), CAT(3), CYP1A2(2), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2), KMO(4), KYNU(1), LCMT1(2), LCMT2(1), LNX1(4), MAOA(2), METTL2B(3), METTL6(1), NFX1(2), OGDH(1), OGDHL(4), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), TDO2(2), TPH1(3), TPH2(2), WARS2(2), WBSCR22(3)	46158327	91	48	91	31	29	13	12	22	15	0	0.315	1.000	1.000
509	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(2), BMP5(4), BMP6(2), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(2), GLI1(2), GLI2(2), GLI3(5), HHIP(2), IHH(2), LRP2(22), PRKACG(1), PTCH1(3), RAB23(1), SHH(1), SMO(2), STK36(2), SUFU(3), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1), ZIC2(1)	46475326	85	48	85	35	33	14	12	16	10	0	0.613	1.000	1.000
510	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(2), APOA1(1), CD36(4), CITED2(1), CREBBP(9), DUSP1(1), EHHADH(1), EP300(5), HSD17B4(2), LPL(2), MAPK1(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(8), NCOR2(7), NFKBIA(2), NR1H3(5), NR2F1(1), NRIP1(2), PDGFA(1), PPARA(3), PRKACG(1), PRKAR1A(2), PRKCA(5), PTGS2(2), RB1(6), RELA(1), RXRA(1), STAT5A(1), STAT5B(2), TNF(1)	45360819	85	48	83	31	22	12	10	20	18	3	0.620	1.000	1.000
511	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(5), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHFR(1), DHX58(1), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(3), MOV10L1(3), QDPR(2), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SKIV2L2(3), SMARCA2(2), SMARCA5(2), SPR(1)	47815696	82	47	82	29	26	15	10	17	14	0	0.497	1.000	1.000
512	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), AOX1(5), ASMT(1), CAT(3), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(1), CYP4B1(1), CYP51A1(2), DDC(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), KMO(4), KYNU(1), MAOA(2), SDS(1), TDO2(2), TPH1(3), WARS2(2)	41951055	75	46	75	27	26	11	6	18	14	0	0.481	1.000	1.000
513	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(2), ADCY9(7), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(6), PLCG2(9), PRKCA(5), SEC61A1(1), TRIM23(2)	28202868	55	39	54	23	22	11	6	7	8	1	0.608	1.000	1.000
514	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4A(1), INPP4B(4), INPPL1(5), OCRL(5), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CB(3), PIK3CG(5), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9)	32456392	60	39	59	25	16	12	7	17	8	0	0.710	1.000	1.000
515	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(1), CYP4A22(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2)	37314430	68	35	68	30	16	9	7	20	16	0	0.786	1.000	1.000
516	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CCND1(4), CREBBP(9), EP300(5), ERCC3(2), ESR1(2), GRIP1(2), GTF2E1(3), GTF2F1(1), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), NCOR2(7), NR0B1(1), NRIP1(2), PELP1(2), POLR2A(7)	35177150	61	34	60	24	23	4	5	16	13	0	0.756	1.000	1.000
517	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(1), HADHA(2), HSD17B4(2), HSD3B7(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(1), SETD7(2), SETDB1(7), SHMT1(2), SUV39H1(2), TMLHE(2)	44246315	72	34	72	29	26	7	9	18	12	0	0.578	1.000	1.000
518	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), ARPC1A(2), ARPC1B(1), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(1), LIMK1(4), MYL2(2), MYLK(5), OPHN1(4), PIP5K1B(1), ROCK1(2), TLN1(5), VCL(1)	34569349	52	34	52	20	13	5	7	20	7	0	0.647	1.000	1.000
519	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), DAG1(1), DGKA(3), ITPR1(4), ITPR2(12), ITPR3(13), MAPK1(2), MAPK3(1), PAK1(2), PDE3A(2), PI3(2), PIK3C2G(1), PIK3CD(3), PSME1(3), RPS4X(2), SGCB(1)	34230224	58	34	58	26	12	5	14	15	10	2	0.844	1.000	1.000
520	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	AKT1(1), CALM3(1), CHRM1(2), CHRNA1(4), FLT1(5), FLT4(6), KDR(6), NOS3(7), PDE2A(4), PDE3A(2), PRKACG(1), PRKAR1A(2), PRKG1(1), PRKG2(1), SLC7A1(2), SYT1(1), TNNI1(1)	24184578	47	33	47	24	14	7	11	9	6	0	0.825	1.000	1.000
521	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(1), CBR3(1), CYP4F3(4), EPX(5), GGT1(2), LPO(5), LTA4H(4), MPO(2), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(6)	21251572	52	33	52	19	16	13	6	9	7	1	0.265	1.000	1.000
522	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(3), FUT6(2), GBGT1(2), GCNT2(1), PIGA(3), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST3GAL6(3), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3), UGCG(2)	37013996	65	32	65	23	23	8	5	19	10	0	0.507	1.000	1.000
523	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), ARHGEF11(2), BCL2(1), DLG4(3), GNA13(1), LPA(7), MAP3K1(3), MAP3K5(3), MAPK8(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PI3(2), PIK3CB(3), PLD1(7), PLD3(1), PTK2(2), RDX(5), ROCK1(2), ROCK2(4), SERPINA4(2), SRF(2), TBXA2R(1)	37424850	66	32	66	23	18	10	11	20	6	1	0.462	1.000	1.000
524	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT1(1), DAG1(1), ITPR1(4), ITPR2(12), ITPR3(13), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PIK3CB(3), PITX2(4), PLD1(7), PLD3(1)	34177495	61	32	61	26	20	8	11	17	3	2	0.652	1.000	1.000
525	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), ANKRD6(2), APC(2), AXIN1(1), AXIN2(1), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(1), DKK2(2), DKK4(2), LRP1(20), NKD1(1), NKD2(4), PTPRA(4), SENP2(3), SFRP1(1), WIF1(2)	30710260	55	30	54	21	15	9	5	15	11	0	0.758	1.000	1.000
526	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(4), ITPR2(12), ITPR3(13), NFAT5(3), PDE6A(2), PDE6B(3), PDE6C(7), SLC6A13(2), TF(2)	27295249	55	30	55	22	16	10	11	12	5	1	0.476	1.000	1.000
527	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), ELK1(3), FOS(1), IKBKB(1), IRAK1(1), MAP2K3(3), MAP3K1(3), MAPK8(2), NFKB1(1), NFKBIA(2), PPARA(3), RELA(1), TLR10(5), TLR2(1), TLR3(5), TLR4(2), TLR6(3), TLR7(6), TLR9(3), TOLLIP(1)	27835313	48	30	47	20	16	7	8	13	4	0	0.636	1.000	1.000
528	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH4A1(2), ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(4), GOT1(2), MAOA(2), NOS1(5), NOS3(7), OAT(1), ODC1(3), P4HA1(1), RARS(2), SMS(2)	33655967	59	29	59	24	18	11	6	14	10	0	0.611	1.000	1.000
529	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS1(1), ALAS2(1), AMT(1), ATP6V0C(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(2), GARS(3), GCAT(1), GLDC(2), MAOA(2), PISD(1), PLCB2(4), PLCG1(6), PLCG2(9), PSPH(1), SARDH(2), SARS(1), SHMT1(2)	32027069	51	29	50	19	16	15	3	10	7	0	0.283	1.000	1.000
530	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(1), CD97(2), CRHR2(3), ELTD1(1), EMR1(4), EMR2(5), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GPR64(3), LPHN1(1), LPHN2(7), LPHN3(5), SCTR(1), VIPR1(1), VIPR2(1)	20325843	45	29	45	21	11	8	10	14	2	0	0.800	1.000	1.000
531	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG2(2), ASL(2), ASS1(3), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), EPRS(3), GLUD1(4), GLUD2(1), GOT1(2), LAP3(1), NOS1(5), NOS3(7), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4)	27330755	51	28	51	22	15	10	5	13	8	0	0.733	1.000	1.000
532	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(2), FUCA2(4), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NEU1(1), NEU2(5), NEU3(2)	15530173	39	28	39	16	12	3	7	11	6	0	0.720	1.000	1.000
533	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC10(1), ANAPC11(1), ANAPC2(2), ANAPC5(5), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(4), CUL1(1), CUL2(6), CUL3(1), FBXW7(5), FZR1(3), RBX1(1), SKP2(3), SMURF1(2), SMURF2(2), UBE2D4(2), WWP1(3), WWP2(1)	30661395	52	28	52	22	14	9	9	16	4	0	0.816	1.000	1.000
534	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B4(1), EIF2S2(1), FLT1(5), FLT4(6), KDR(6), NOS3(7), PLCG1(6), PRKCA(5), PTK2(2), SHC1(1)	23024805	41	28	40	23	9	6	8	12	5	1	0.952	1.000	1.000
535	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(1), CREB1(1), CREB3(3), DUSP1(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(3), IL1R1(2), MAP2K3(3), MAP3K10(1), MAP3K4(4), MAP3K5(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(1), NR2C2(2), SRF(2)	25383431	46	27	46	21	13	3	10	13	7	0	0.853	1.000	1.000
536	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA1(1), APOA4(3), APOE(2), CETP(1), CYP7A1(2), LIPC(1), LPL(2), LRP1(20), SCARB1(1), SOAT1(2)	20867206	41	26	41	17	10	8	4	14	5	0	0.746	1.000	1.000
537	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(1), CFL1(1), GNAS(4), LIMK1(4), MAPK1(2), MAPK3(1), MYL2(2), NOX1(1), PIK3C2G(1), PLCB1(3), PRKCA(5), PTK2(2), RAF1(1), ROCK2(4)	19157942	34	24	34	11	6	2	7	12	5	2	0.536	1.000	1.000
538	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(3), CXCR4(2), GNAI1(4), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(6), PRKCA(5), PTK2(2), PTK2B(2), RAF1(1), RELA(1)	18179763	31	24	30	18	7	3	7	7	5	2	0.940	1.000	1.000
539	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM3(1), CAMK1(1), CAMK1G(1), ELK1(3), FPR1(1), GNA15(1), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAPK1(2), MAPK3(1), NCF1(2), NCF2(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(2), PAK1(2), PIK3C2G(1), PLCB1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1), SYT1(1)	29198737	51	24	51	21	15	5	6	13	11	1	0.581	1.000	1.000
540	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(5), ARRB2(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CLCA1(3), CLCA2(4), CLCA4(1), CNGA3(4), CNGA4(1), CNGB1(3), GNAL(1), GUCA1A(1), PDC(1), PDE1C(5), PRKACG(1), PRKG1(1), PRKG2(1)	23256927	44	23	44	19	19	6	3	10	6	0	0.590	1.000	1.000
541	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ATP6V0C(1), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(1), HADHA(2), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2)	28251030	49	23	49	21	18	7	7	9	8	0	0.518	1.000	1.000
542	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(13), C5(6), C6(3), C7(5), C8A(2), C8B(4), MASP1(2)	15822569	44	22	44	22	16	6	3	14	5	0	0.856	1.000	1.000
543	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(13), C5(6), C6(3), C7(5), C8A(2), MASP1(2), MBL2(3)	16182545	43	22	43	18	16	4	4	13	6	0	0.696	1.000	1.000
544	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDK2(1), CDT1(1), DIAPH2(2), GMNN(1), MCM10(4), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), NACA(5), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), PRIM1(1), RFC1(1), RFC4(3), RPA1(3), UBC(5)	38615485	57	22	57	30	8	6	7	21	15	0	0.972	1.000	1.000
545	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM7(3), GRM8(2)	16034603	35	22	35	18	14	5	2	9	5	0	0.810	1.000	1.000
546	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(3), ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(2), SOAT2(1), SRD5A1(1)	24031038	52	22	52	24	13	5	8	21	5	0	0.867	1.000	1.000
547	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(2), AKR1B10(2), ALAS1(1), ALAS2(1), AMT(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(2), GARS(3), GCAT(1), GLDC(2), HSD3B7(1), MAOA(2), PHGDH(4), PIPOX(1), PISD(1), PSAT1(2), PSPH(1), SARDH(2), SARS(1), SARS2(1), SDS(1), SHMT1(2), TARS2(1)	32498870	44	22	44	16	11	13	4	10	6	0	0.284	1.000	1.000
548	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), DARS2(2), EARS2(1), EPRS(3), FARS2(3), GARS(3), HARS(2), HARS2(1), IARS(1), IARS2(3), LARS(4), MARS(5), MARS2(2), MTFMT(1), NARS(1), NARS2(1), PARS2(1), QARS(3), RARS(2), RARS2(4), SARS(1), SARS2(1), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1)	41343983	56	22	56	17	7	15	6	19	9	0	0.415	1.000	1.000
549	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(2), AXIN1(1), CREBBP(9), CTNNB1(3), EP300(5), FZD1(2), LDB1(2), LEF1(1), PITX2(4), TRRAP(12)	25291335	41	22	41	16	13	4	6	12	6	0	0.641	1.000	1.000
550	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(1), POLB(3), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLG(1), POLH(1), POLI(3), POLK(2), POLL(1), POLM(3), POLQ(4), PRIM1(1), PRIM2(1), REV1(3), REV3L(7)	30868620	47	21	47	18	11	6	6	15	9	0	0.815	1.000	1.000
551	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(2), ANXA5(1), ANXA6(3), CYP11A1(4), EDNRA(1), EDNRB(1), PLA2G4A(4), PRL(1), PTGER4(1), PTGFR(6), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(1)	15744427	34	21	34	16	9	3	4	12	6	0	0.837	1.000	1.000
552	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(3), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNF(1), TRADD(1), TRAF2(2)	18386194	26	21	26	11	9	6	2	4	5	0	0.654	1.000	1.000
553	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGT(2), AGTR2(3), EDNRA(1), EDNRB(1), EGF(7), FOS(1), NFKB1(1), PLCG1(6), PRKCA(5), RELA(1)	13635065	28	20	27	13	8	5	3	9	2	1	0.783	1.000	1.000
554	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(13), C5(6), C6(3), C7(5), C8A(2)	13311548	38	20	38	16	14	3	3	13	5	0	0.728	1.000	1.000
555	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ASPA(1), CNDP1(2), DDC(2), HAL(1), HARS(2), HDC(2), HNMT(1), MAOA(2), PRPS1(1), PRPS2(3)	18638396	33	20	33	13	15	5	4	7	2	0	0.489	1.000	1.000
556	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL6(1), IRAK1(1), IRAK2(2), IRAK3(6), MAP2K3(3), MAP3K1(3), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1)	22587364	34	20	34	13	9	7	6	7	5	0	0.504	1.000	1.000
557	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPNS1(1), CAPNS2(1), EGF(7), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PRKACG(1), PRKAR1A(2), PTK2(2), TLN1(5)	22903398	33	20	33	15	13	1	8	7	3	1	0.757	1.000	1.000
558	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(2), ARHGEF1(1), F2(3), F2R(2), F2RL3(1), GNA13(1), GNAI1(4), PLCB1(3), PRKCA(5), PTK2B(2), ROCK1(2)	16829465	26	20	26	16	6	3	5	8	3	1	0.928	1.000	1.000
559	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(3), ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), SOAT2(1), SRD5A1(1)	17702128	36	19	36	17	10	4	5	13	4	0	0.802	1.000	1.000
560	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(5), CR2(4), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7)	11592340	25	19	25	10	8	6	1	6	4	0	0.555	1.000	1.000
561	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(3), F2R(2), FGA(6), FGB(1), FGG(1), PLAT(1), PLAU(1), PLG(4), SERPINB2(2), SERPINE1(2)	10221119	26	19	26	11	8	3	3	7	5	0	0.698	1.000	1.000
562	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GPHN(1), NSF(2), UBQLN1(2)	9130343	28	19	28	11	5	8	3	7	5	0	0.645	1.000	1.000
563	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2)	15810266	27	19	27	11	13	1	5	7	1	0	0.648	1.000	1.000
564	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), BCL2(1), CBL(1), CFLAR(1), CRKL(1), E2F1(1), FOS(1), IL2RB(2), IRS1(4), JAK1(1), JAK3(3), MAPK1(2), MAPK3(1), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	24700742	31	19	31	14	5	7	3	8	7	1	0.721	1.000	1.000
565	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(6), BCAR1(3), BCR(3), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), SOS1(4), TLN1(5), VCL(1)	35951535	44	19	44	16	15	6	8	10	4	1	0.464	1.000	1.000
566	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(9), DUSP1(1), EP300(5), IKBKB(1), IL1B(2), MAP2K3(3), NFKB1(1), NFKBIA(2), NR3C1(3), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1), TNF(1)	22636812	35	19	35	15	9	6	4	11	5	0	0.746	1.000	1.000
567	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(2), NCOA2(2), NCOA3(4), NCOR2(7), POLR2A(7), RXRA(1)	18996749	30	19	29	21	6	6	1	11	6	0	0.992	1.000	1.000
568	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(1), TAF9(2)	26732547	39	19	39	24	10	6	4	14	5	0	0.982	1.000	1.000
569	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(13), C5(6), C6(3), C7(5), C8A(2)	9566157	29	18	29	13	11	2	3	8	5	0	0.728	1.000	1.000
570	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(3), FOS(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2)	17782970	25	18	25	10	4	6	2	7	5	1	0.526	1.000	1.000
571	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(3), DPAGT1(2), DPM1(2), FUT8(6), MAN1A1(2), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(1), ST6GAL1(1)	15161357	31	18	31	11	6	10	5	3	7	0	0.376	1.000	1.000
572	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD7(1), IFNB1(1), IL10(1), IL12B(2), IL3(1), IL5(1), ITGAX(2), TLR2(1), TLR4(2), TLR7(6), TLR9(3)	14182948	25	17	24	15	6	2	4	10	3	0	0.949	1.000	1.000
573	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(2), CA1(1), CA12(2), CA13(1), CA14(1), CA2(1), CA5A(1), CA6(1), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(4), GLUD2(1), GLUL(1), HAL(1)	16202851	25	17	25	14	7	5	1	8	4	0	0.920	1.000	1.000
574	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1)	17895966	31	17	31	13	8	3	5	11	4	0	0.727	1.000	1.000
575	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1R1(2), IRAK1(1), MAP3K1(3), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1)	18554607	22	17	22	15	11	3	2	2	4	0	0.947	1.000	1.000
576	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR2(2), CCR3(1), CCR4(1), CCR7(1), CD28(1), CD4(1), CXCR4(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(2), IL5(1), TGFB2(2), TGFB3(1)	15230009	24	17	24	16	6	3	4	9	2	0	0.958	1.000	1.000
577	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), CASP8(2), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NR2C2(2), RALBP1(2), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1), TRAF2(2)	20739828	28	17	28	11	12	5	2	4	5	0	0.609	1.000	1.000
578	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(3), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNFAIP3(2), TNFRSF1B(2), TRAF2(2), TRAF3(1)	17107871	23	17	23	10	11	3	1	3	5	0	0.636	1.000	1.000
579	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(4), E2F1(1), ETS1(3), ETV3(1), FOS(1), HDAC2(4), HDAC5(1), NCOR2(7), RBL1(4), RBL2(3), SIN3A(3), SIN3B(1)	19780306	33	16	33	13	8	5	4	7	9	0	0.680	1.000	1.000
580	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GPX4(1), GPX6(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), OPLAH(2)	15538927	29	16	29	14	9	8	5	4	3	0	0.708	1.000	1.000
581	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), CHST1(1), CHST4(1), FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	9512730	18	16	18	11	6	3	4	3	2	0	0.897	1.000	1.000
582	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(9), EP300(5), FYN(1), IL7R(1), JAK1(1), JAK3(3), LCK(1), PTK2B(2), STAT5A(1), STAT5B(2)	18468468	27	16	27	11	6	3	3	11	4	0	0.751	1.000	1.000
583	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(2), CA1(1), CA12(2), CA14(1), CA2(1), CA5A(1), CA6(1), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(4), GLUL(1), HAL(1)	14500153	23	16	23	10	7	4	1	7	4	0	0.756	1.000	1.000
584	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(2), EEA1(3), GRASP(1), PFKL(4), PFKP(1), PLCG1(6), RAC1(1), RPS6KB1(2), VAV2(2)	18970402	26	16	25	15	7	6	3	5	5	0	0.879	1.000	1.000
585	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GPX4(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), PGD(1)	12522639	23	15	23	13	7	4	5	3	4	0	0.882	1.000	1.000
586	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(9), EP300(5), HDAC3(1), IKBKB(1), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1)	17058765	27	15	27	11	9	3	1	8	6	0	0.690	1.000	1.000
587	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(9), EP300(5), NCOA3(4), PRKACG(1), PRKAR1A(2), RXRA(1)	15783936	23	14	23	10	7	3	1	8	4	0	0.794	1.000	1.000
588	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(2), DHCR24(2), DHCR7(3), FDFT1(1), FDPS(1), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), LSS(1), MVD(3), NQO1(1), NSDHL(2), SQLE(1)	14660783	24	14	23	11	7	3	5	6	3	0	0.804	1.000	1.000
589	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2)	15570476	26	14	26	11	10	7	0	3	6	0	0.420	1.000	1.000
590	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNGR2(1), IKBKB(1), JAK2(4), NFKB1(1), NFKBIA(2), RB1(6), RELA(1), TNF(1), TNFRSF1B(2), USH1C(2), WT1(1)	13193469	25	14	25	10	5	2	2	6	10	0	0.753	1.000	1.000
591	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), FUT2(2), FUT5(3), FUT6(2), GCNT2(1), ST3GAL6(3), ST8SIA1(1)	12357989	21	13	21	11	6	3	2	6	4	0	0.884	1.000	1.000
592	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR2(1), SNAP29(1), STX11(2), STX16(1), TSNARE1(2), USE1(2), VAMP4(1), VAMP5(2), VAMP8(1), VTI1A(2)	12713081	17	13	16	10	7	3	3	1	3	0	0.840	1.000	1.000
593	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(6), PRKCA(5), PTK2B(2)	5139223	15	13	14	10	4	3	2	4	1	1	0.904	1.000	1.000
594	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(1), GNA13(1), MYL2(2), MYLK(5), PLCB1(3), PRKCA(5), ROCK1(2)	15731746	21	13	21	12	8	2	4	5	1	1	0.861	1.000	1.000
595	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(2), ALOX5(1), ALOX5AP(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGES(1), PTGS1(2), PTGS2(2), TBXAS1(1)	11459224	19	12	19	10	5	6	2	2	4	0	0.806	1.000	1.000
596	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK1(1), JAK2(4), JAK3(3), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), TYK2(7)	14030163	23	12	23	10	6	0	2	10	4	1	0.814	1.000	1.000
597	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ECHS1(2), EHHADH(1), HADHA(2), SDS(1)	9265337	20	12	20	11	8	2	3	3	4	0	0.782	1.000	1.000
598	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), DHFR(1), HPRT1(1), IMPDH1(3), OAZ1(1), POLB(3), POLD1(2), POLG(1), PRPS2(3), RRM1(3), SRM(2)	9483692	24	12	24	10	8	5	5	4	2	0	0.540	1.000	1.000
599	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(3), ELOVL2(1), ELOVL6(1), FADS2(2), FASN(3), HADHA(2), PECR(2), SCD(1)	10908483	17	11	17	15	3	3	2	7	2	0	0.990	1.000	1.000
600	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(3), DCN(2), FMOD(1), KERA(4), LUM(2)	2766981	12	11	12	6	1	2	3	6	0	0	0.809	1.000	1.000
601	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7)	8208258	14	11	14	10	6	4	0	3	1	0	0.901	1.000	1.000
602	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7)	8611085	15	11	15	10	6	4	0	4	1	0	0.889	1.000	1.000
603	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	16	CBS(4), CTH(1), DNMT1(3), DNMT3B(4), MARS(5), MARS2(2), MTFMT(1), MTR(2), SRM(2), TAT(1)	14407665	25	10	25	11	6	6	1	8	2	2	0.672	1.000	1.000
604	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(4)	12687575	21	9	21	12	7	3	2	8	1	0	0.920	1.000	1.000
605	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	FYN(1), RELN(12), VLDLR(2)	10689186	15	8	15	10	6	5	1	2	1	0	0.866	1.000	1.000
606	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(3), PPARG(2), RXRA(1), TNF(1)	4434246	9	8	9	5	1	3	1	4	0	0	0.750	1.000	1.000
607	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(1), CNR2(2), DNMT1(3), MTNR1A(2), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(6), TBXA2R(1)	8495625	19	7	19	10	6	3	0	9	1	0	0.808	1.000	1.000
608	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(1), UBE2G2(1), UBE2J2(1), UBE2L6(1), UBE2M(1)	8029378	7	7	7	11	4	0	1	1	1	0	0.999	1.000	1.000
609	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2)	4303186	10	5	10	6	1	1	1	7	0	0	0.910	1.000	1.000
610	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2), EIF2S2(1), PPP1CA(1)	8807549	6	4	6	7	1	1	2	2	0	0	0.987	1.000	1.000
611	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(2), P2RY6(2)	4553771	8	3	8	6	4	2	0	2	0	0	0.902	1.000	1.000
612	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1)	4638088	2	2	2	3	0	0	2	0	0	0	0.968	1.000	1.000
613	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		548681	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		388742	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		1167814	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		1307056	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
