rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), BCL2(5), EGFR(87), IGF1R(8), MYC(4), POLR2A(11), PPP2CA(1), PRKCA(10), RB1(33), TEP1(39), TERF1(4), TERT(7), TNKS(11), TP53(309), XRCC5(9)	22681635	541	351	357	50	62	137	64	70	205	3	<1.00e-15	<1.00e-15	<1.23e-13
2	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CDK2(1), CDK4(3), CHEK1(7), MYT1(24), RB1(33), TP53(309), WEE1(4), YWHAH(1)	14151904	448	341	310	18	54	107	51	50	181	5	<1.00e-15	<1.00e-15	<1.23e-13
3	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(10), CDKN2A(23), E2F1(3), MDM2(5), MYC(4), PIK3CA(30), PIK3R1(4), POLR1A(13), POLR1B(11), POLR1D(2), RB1(33), TBX2(8), TP53(309), TWIST1(2)	16255854	457	322	307	32	58	124	63	43	166	3	<1.00e-15	<1.00e-15	<1.23e-13
4	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(4), MAX(8), MYC(4), SP1(6), SP3(6), TP53(309), WT1(16)	5699587	353	306	218	17	48	96	38	36	132	3	<1.00e-15	<1.00e-15	<1.23e-13
5	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(7), DNAJC3(5), EIF2S2(3), NFKB1(6), NFKBIA(4), RELA(3), TP53(309)	7863806	337	303	203	18	43	87	37	38	129	3	<1.00e-15	<1.00e-15	<1.23e-13
6	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(10), ATM(53), BRCA1(22), CDKN1A(2), CHEK1(7), CHEK2(10), GADD45A(2), JUN(3), MAPK8(2), MDM2(5), MRE11A(13), NFKB1(6), NFKBIA(4), RAD50(10), RAD51(2), RBBP8(6), RELA(3), TP53(309), TP73(7)	23963460	476	347	338	36	59	127	70	56	159	5	<1.00e-15	1.44e-15	1.44e-13
7	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(10), ATM(53), BAX(3), BCL2(5), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDKN1A(2), E2F1(3), GADD45A(2), MDM2(5), PCNA(1), RB1(33), TIMP3(4), TP53(309)	14566640	444	342	306	25	53	112	57	50	167	5	<1.00e-15	1.89e-15	1.44e-13
8	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(10), ATM(53), BAD(1), BAX(3), BCL2(5), BCL2L1(3), BID(2), CASP3(5), CASP6(3), CASP7(3), CASP9(6), CYCS(2), PRKCA(10), PTK2(6), PXN(2), STAT1(7), TLN1(15), TP53(309)	22055995	448	350	311	45	54	128	57	52	152	5	2.33e-14	2.00e-15	1.44e-13
9	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(45), AKT1(3), ATM(53), BAX(3), CDKN1A(2), CPB2(6), CSNK1A1(2), CSNK1D(7), FHL2(3), GADD45A(2), HIC1(1), HIF1A(2), IGFBP3(4), MAPK8(2), MDM2(5), NFKBIB(3), TP53(309)	16675533	452	346	315	29	53	132	58	51	153	5	<1.00e-15	2.11e-15	1.44e-13
10	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(53), ATR(26), BRCA1(22), BRCA2(34), CHEK1(7), CHEK2(10), FANCA(7), FANCC(2), FANCD2(5), FANCE(3), FANCF(6), FANCG(7), HUS1(4), MRE11A(13), RAD1(1), RAD17(6), RAD50(10), RAD51(2), RAD9A(2), TP53(309), TREX1(1)	35575939	530	355	393	37	58	146	87	68	166	5	<1.00e-15	2.78e-15	1.62e-13
11	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(30), DAXX(8), HRAS(2), PAX3(12), PML(15), RARA(7), RB1(33), SIRT1(2), SP100(18), TNF(2), TNFRSF1B(2), TP53(309)	15237396	440	318	305	24	59	115	61	42	160	3	<1.00e-15	2.89e-15	1.62e-13
12	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(2), IFNG(7), IFNGR1(7), IFNGR2(4), IKBKB(9), JAK2(16), LIN7A(7), NFKB1(6), NFKBIA(4), RB1(33), RELA(3), TNF(2), TNFRSF1B(2), TP53(309), USH1C(24), WT1(16)	14547980	451	333	315	42	55	119	56	42	175	4	<1.00e-15	3.44e-15	1.68e-13
13	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(10), ATM(53), ATR(26), CCNA1(7), CCND1(3), CCNE1(7), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), CDKN2A(23), DHFR(2), E2F1(3), GSK3B(4), HDAC1(4), RB1(33), SKP2(4), TFDP1(11), TGFB1(3), TGFB2(10), TP53(309)	24262756	532	352	389	43	65	141	71	57	193	5	<1.00e-15	3.55e-15	1.68e-13
14	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(53), ATR(26), CDC25C(8), CHEK1(7), CHEK2(10), TP53(309), YWHAH(1)	12948811	414	334	278	13	51	105	51	52	150	5	<1.00e-15	4.77e-15	2.05e-13
15	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(53), ATR(26), BRCA1(22), CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CDC34(2), CDKN1A(2), CDKN2D(2), CHEK1(7), CHEK2(10), EP300(11), GADD45A(2), MDM2(5), MYT1(24), PRKDC(50), RPS6KA1(6), TP53(309), WEE1(4), YWHAH(1), YWHAQ(4)	33656030	555	364	419	43	61	154	83	69	183	5	<1.00e-15	5.00e-15	2.05e-13
16	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(1), CCND1(3), CDK2(1), CDK4(3), CDKN1A(2), CDKN1B(5), CDKN2A(23), E2F1(3), E2F2(5), MDM2(5), NXT1(2), PRB1(5), TP53(309)	6739941	368	307	229	14	50	101	42	38	134	3	<1.00e-15	6.11e-15	2.35e-13
17	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), FOS(3), FXYD2(1), JUN(3), KEAP1(96), MAFG(1), MAPK1(2), MAPK14(6), MAPK8(2), NFE2L2(17), PRKCA(10)	7086933	143	132	132	13	28	41	26	15	33	0	1.33e-06	1.23e-11	4.46e-10
18	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(13), EGFR(87), HGS(1), RAB5A(2), TF(13), TFRC(7)	10328751	128	105	79	16	7	30	21	31	39	0	0.0170	0.0581	1.000
19	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(13), EGFR(87), ERBB3(11), NRG1(22), UBE2D1(1)	8318955	134	111	83	21	12	28	17	30	47	0	0.0539	0.0839	1.000
20	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), FBXW7(17), RB1(33), TFDP1(11)	6588121	88	68	87	8	7	21	14	8	38	0	0.00113	0.184	1.000
21	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(7), CDK2(1), CDKN1B(5), CKS1B(1), CUL1(14), E2F1(3), NEDD8(3), RB1(33), SKP2(4), TFDP1(11), UBE2M(1)	6881889	83	68	82	9	7	15	16	7	38	0	0.00601	0.226	1.000
22	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), FADD(2), FAS(4), FASLG(11), GZMB(8), JUN(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MCL1(2), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), PARP1(4), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TNFSF10(3), TP53(309), TRADD(2), TRAF1(2), TRAF2(5)	30063453	491	335	357	66	54	157	74	53	150	3	5.05e-12	0.327	1.000
23	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), RB1(33), SKP2(4), TFDP1(11)	6820981	82	66	81	9	7	21	15	7	32	0	0.00449	0.373	1.000
24	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(8), GOT1(3), GOT2(6), TAT(9), TYR(29)	3808360	55	53	55	9	8	22	11	6	8	0	0.0326	0.652	1.000
25	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(6), TAT(9)	2128311	18	18	18	2	5	7	3	2	1	0	0.0759	0.657	1.000
26	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(7), IL12A(2), IL12B(3), IL2(7)	2403481	27	26	27	5	1	16	0	1	8	1	0.201	0.761	1.000
27	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(13), EGFR(87), MAP2K1(10), MAP3K1(7), MAPK14(6), NCOR2(30), RARA(7), RXRA(1), THRA(6), THRB(4)	13649211	171	136	121	27	11	40	29	38	53	0	0.0182	0.807	1.000
28	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	584333	7	7	7	3	2	1	0	2	2	0	0.742	0.931	1.000
29	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(6), SLPI(1)	1382720	7	7	6	1	1	2	1	1	2	0	0.354	0.939	1.000
30	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(9)	1324024	11	10	11	3	1	3	5	0	2	0	0.593	0.965	1.000
31	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(2)	1235104	4	4	4	0	0	1	0	1	2	0	0.495	0.973	1.000
32	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(10), CDC42(2), DLD(9), DUSP10(11), DUSP4(2), DUSP8(2), GAB1(7), GADD45A(2), GCK(7), IL1R1(2), JUN(3), MAP2K4(8), MAP2K5(4), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(8), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK10(6), MAPK7(7), MAPK8(2), MAPK9(8), MYEF2(12), NFATC3(16), NR2C2(2), PAPPA(32), SHC1(6), TP53(309), TRAF6(6), ZAK(12)	40358111	616	357	480	79	87	197	89	63	177	3	5.33e-15	0.974	1.000
33	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(12), MTMR2(2), MTMR6(9), NFS1(5), PHPT1(1), THTPA(2), TPK1(13)	5148488	47	42	45	6	3	18	13	6	7	0	0.0364	0.979	1.000
34	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(5), CD4(8), CD80(3), HLA-DRA(3), HLA-DRB1(5), IL10(2), IL2(7), IL4(1)	3223968	34	29	30	7	1	14	1	4	14	0	0.387	0.984	1.000
35	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(7), PAPSS1(5), PAPSS2(10), SULT1A2(5), SULT1E1(11), SULT2A1(6), SUOX(5)	4954097	49	45	49	7	3	22	9	7	8	0	0.0373	0.984	1.000
36	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(8), GLS2(6), GLUD1(4), GLUD2(15)	3672284	33	31	33	5	0	17	9	2	5	0	0.130	0.987	1.000
37	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(44), CPEB1(13), EGFR(87), ERBB2(12), ERBB4(52), ETS1(8), ETS2(6), ETV6(5), ETV7(2), FMN2(65), GRB2(7), KRAS(169), MAP2K1(10), MAPK1(2), MAPK3(3), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), PIWIL1(17), PIWIL2(10), PIWIL3(9), PIWIL4(7), RAF1(6), SOS1(17), SOS2(13), SPIRE1(5), SPIRE2(5)	41513875	690	397	448	98	52	331	125	64	115	3	6.23e-14	0.990	1.000
38	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(8), ALDH1A2(8), BCMO1(6), RDH5(1)	3156193	23	23	23	4	1	10	5	4	3	0	0.203	0.990	1.000
39	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2), CD3E(2)	923089	4	4	4	2	0	0	1	1	2	0	0.858	0.993	1.000
40	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(5), IDI1(2), SQLE(4)	2563848	15	15	15	3	2	5	4	1	3	0	0.434	0.995	1.000
41	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(9), HLCS(3), SPCS1(1), SPCS3(2)	2479058	15	15	15	3	1	6	6	1	1	0	0.352	0.996	1.000
42	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(10), ATM(53), ATR(26), BAI1(24), BAX(3), BID(2), CASP3(5), CASP8(6), CASP9(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG1(2), CCNG2(1), CD82(5), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN2A(23), CHEK1(7), CHEK2(10), CYCS(2), DDB2(3), EI24(1), FAS(4), GADD45A(2), GADD45B(1), GADD45G(1), GTSE1(6), IGF1(4), IGFBP3(4), MDM2(5), MDM4(4), PERP(1), PPM1D(8), PTEN(11), RCHY1(2), RFWD2(16), RRM2(6), RRM2B(3), SERPINB5(10), SERPINE1(14), SESN1(1), SESN2(5), SESN3(2), SFN(1), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(3), TP53(309), TP53I3(2), TP73(7), TSC2(13), ZMAT3(5)	52014903	715	379	572	90	81	225	118	80	204	7	<1.00e-15	0.996	1.000
43	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(5)	1692843	8	7	8	2	0	4	0	2	2	0	0.527	0.996	1.000
44	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(5), CD4(8), HLA-DRA(3), HLA-DRB1(5)	1927106	21	20	17	6	1	9	1	3	7	0	0.671	0.997	1.000
45	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(7), CCNA2(6), CCND1(3), CCNE1(7), CCNE2(3), CDK2(1), CDK4(3), CDKN1B(5), CDKN2A(23), E2F1(3), E2F2(5), E2F4(5), PRB1(5)	7145755	76	65	71	10	10	30	14	5	17	0	0.00562	0.997	1.000
46	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(5), GGPS1(2), IDI1(2), IDI2(1), SQLE(4)	3440819	18	18	18	3	2	7	5	1	3	0	0.308	0.998	1.000
47	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(9)	1454837	15	15	14	5	0	4	4	3	4	0	0.632	0.998	1.000
48	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(3), BFAR(5), BRAF(44), CAMP(4), CREB1(2), CREB3(1), CREB5(18), MAPK1(2), RAF1(6), SNX13(9), SRC(2)	8973163	96	81	71	13	8	42	29	2	14	1	0.00456	0.999	1.000
49	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(6), ALDOB(8), ALDOC(2), TPI1(9)	3157676	27	23	27	5	3	11	7	0	6	0	0.211	0.999	1.000
50	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1)	11082061	102	86	100	12	10	26	15	16	33	2	0.00197	0.999	1.000
51	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(8), GLUD1(4), OAT(3), PRODH(4)	4404565	27	26	27	4	3	11	6	2	5	0	0.131	0.999	1.000
52	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(13), CYP2C9(8)	1642731	21	21	21	7	3	9	4	2	3	0	0.625	0.999	1.000
53	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(5), TGDS(1), UGDH(6), UXS1(6)	3115757	19	18	19	4	2	8	4	2	3	0	0.401	0.999	1.000
54	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(5), TGDS(1), UGDH(6), UGP2(4), UXS1(6)	3969223	23	22	23	4	2	8	5	3	5	0	0.338	0.999	1.000
55	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(5), COQ5(3), COQ6(2), COQ7(5), NDUFA12(5), NDUFA13(2), NDUFB11(6)	3215199	29	26	29	6	6	7	4	4	8	0	0.267	0.999	1.000
56	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD28(5), CD3D(2), CD3E(2), CD4(8)	2606736	21	21	21	6	1	9	1	5	5	0	0.456	1.000	1.000
57	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(4), EHHADH(13), HADHA(3), SDS(4)	3872652	25	23	24	5	4	8	5	4	4	0	0.265	1.000	1.000
58	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(5)	1795382	9	8	9	4	1	2	0	2	4	0	0.846	1.000	1.000
59	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(4), GBA3(1), GGT1(1), SHMT1(2), SHMT2(2)	3314036	10	10	9	0	2	3	3	1	1	0	0.0642	1.000	1.000
60	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCR3(4), HLA-DRA(3), HLA-DRB1(5), IL3(4), IL5(2)	2466150	20	20	16	6	0	5	5	4	6	0	0.842	1.000	1.000
61	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(2), CHEK1(7), NEK1(11), WEE1(4)	5532285	32	30	32	5	1	11	8	5	7	0	0.214	1.000	1.000
62	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(6), TYR(29)	7810350	96	87	95	18	10	40	19	11	16	0	0.0418	1.000	1.000
63	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(17), PARK2(15), SNCA(5), SNCAIP(12), UBE2E2(4), UBE2G2(1), UBE2L3(1), UBE2L6(1)	5191088	56	53	56	13	8	26	12	2	8	0	0.175	1.000	1.000
64	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), APEX1(3), CREBBP(30), DFFA(3), DFFB(4), GZMA(8), GZMB(8), PRF1(8), SET(1)	8510668	68	56	68	9	8	28	15	5	12	0	0.00579	1.000	1.000
65	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(2), HMGCL(1), OXCT1(7)	2736802	12	12	12	9	1	3	3	2	3	0	0.994	1.000	1.000
66	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), NFYC(6), RB1(33), SP1(6), SP3(6)	5366971	53	50	52	12	0	6	10	2	35	0	0.669	1.000	1.000
67	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(10), BAD(1), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), BIRC2(2), BIRC3(4), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(11), GZMB(8), HELLS(4), IKBKB(9), IRF1(1), IRF2(3), IRF3(1), IRF4(12), IRF5(1), IRF6(12), IRF7(3), JUN(3), LTA(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), NFKBIB(3), NFKBIE(2), PLEKHG5(10), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFSF10(3), TP53(309), TP73(7), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4)	45868695	612	351	479	87	68	198	97	65	181	3	2.65e-13	1.000	1.000
68	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(8), PLCD1(5), PRKCA(10), TGM2(6)	3986370	29	26	29	8	5	13	3	5	3	0	0.296	1.000	1.000
69	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(8), ACADS(1), ACAT1(2), ECHS1(4), HADHA(3)	4325350	22	21	22	8	0	4	5	4	9	0	0.883	1.000	1.000
70	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAK1(3), BAX(3), BFAR(5), BTK(25), CAD(26), CASP10(7), CASP3(5), CASP8(6), CSNK1A1(2), DAXX(8), DEDD(2), DEDD2(3), DFFA(3), DIABLO(1), EGFR(87), EPHB2(11), FADD(2), FAF1(10), FAIM2(6), HSPB1(1), IL1A(4), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MET(22), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR0B2(3), PFN1(1), PFN2(1), PTPN13(21), RALBP1(3), RIPK1(11), ROCK1(19), SMPD1(3), TNFRSF6B(1), TP53(309), TPX2(12), TRAF2(5), TUFM(5)	58000166	740	391	555	104	78	220	114	98	226	4	1.93e-14	1.000	1.000
71	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(22), PDXK(3), PNPO(2), PSAT1(5)	3885247	32	28	32	9	3	13	8	5	3	0	0.463	1.000	1.000
72	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(3), EGR1(6), HRAS(2), KLK2(11), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(5), RAF1(6)	6499475	52	48	48	10	6	22	13	4	7	0	0.0370	1.000	1.000
73	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(5), CD3D(2), CD3E(2), CD80(3), CD86(11), CTLA4(3), GRB2(7), HLA-DRA(3), HLA-DRB1(5), ICOS(5), IL2(7), ITK(16), LCK(13), PIK3CA(30), PIK3R1(4), PTPN11(9)	10376357	125	102	110	26	7	54	22	14	28	0	0.115	1.000	1.000
74	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(4), CD4(8), HLA-DRA(3), HLA-DRB1(5), IL1B(1), IL4(1), IL5(2), IL5RA(10), IL6(2)	4330878	38	37	34	10	1	11	8	5	13	0	0.618	1.000	1.000
75	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3)	6404267	49	44	49	11	5	19	11	7	7	0	0.165	1.000	1.000
76	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3)	6404267	49	44	49	11	5	19	11	7	7	0	0.165	1.000	1.000
77	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT1(2), ACAT2(2), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), SDS(4)	6711531	40	37	39	9	4	12	13	6	5	0	0.325	1.000	1.000
78	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(23), CDKN2D(2), E2F1(3), RB1(33), RBL1(7), TFDP1(11)	12813726	129	103	123	23	10	37	20	12	50	0	0.0432	1.000	1.000
79	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(7), DCN(5), FMOD(3), KERA(7), LUM(17)	2934698	39	33	39	11	3	11	14	5	6	0	0.501	1.000	1.000
80	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL16(28), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL9(1), LTA(3), TNF(2)	8021597	85	70	85	20	5	48	10	10	11	1	0.0680	1.000	1.000
81	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(5), CD36(4), FOS(3), FYN(9), JUN(3), MAPK14(6), THBS1(8)	5972133	38	34	38	9	5	11	6	3	13	0	0.408	1.000	1.000
82	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(7), ENO2(2), ENO3(3), FARS2(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3)	6722782	49	46	49	10	7	19	11	4	8	0	0.113	1.000	1.000
83	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(8), ERBB4(52), NRG2(3), NRG3(31), PRKCA(10), PSEN1(6)	7252332	110	92	109	28	13	48	22	12	15	0	0.176	1.000	1.000
84	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(5), CASP7(3), DFFA(3), DFFB(4), GZMB(8), HMGB1(2), TOP2A(10), TOP2B(10)	7110700	45	39	45	8	0	12	12	5	16	0	0.342	1.000	1.000
85	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(5), CASP3(5), CASP8(6), CFLAR(2)	3134220	18	17	18	9	1	6	7	1	3	0	0.923	1.000	1.000
86	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(6), SRP54(5), SRP68(4), SRP72(9), SRPR(5)	6095457	33	29	32	7	2	8	12	2	9	0	0.557	1.000	1.000
87	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(34), RANGAP1(4)	6781581	39	36	39	8	6	16	9	4	4	0	0.268	1.000	1.000
88	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(7), NR1I3(10), PTGS1(19), PTGS2(12)	4326176	51	44	50	13	4	25	11	3	8	0	0.138	1.000	1.000
89	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5)	4573767	48	43	45	14	3	28	7	2	8	0	0.465	1.000	1.000
90	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(53), CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(23), CDKN2D(2), CREB3(1), CREB3L1(4), CREB3L3(4), CREB3L4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), GADD45A(2), GBA2(5), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MNAT1(2), MYC(4), MYT1(24), NACA(15), PCNA(1), POLA2(7), POLE(31), POLE2(1), PRIM1(3), RB1(33), RBL1(7), RPA1(2), RPA2(2), RPA3(1), TFDP1(11), TFDP2(7), TNXB(32), TP53(309), WEE1(4)	61819242	722	384	579	98	95	212	102	74	233	6	<1.00e-15	1.000	1.000
91	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), SDS(4)	9729696	73	64	72	15	8	27	16	11	11	0	0.0769	1.000	1.000
92	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(6), LHPP(3), MTMR1(12), MTMR2(2), MTMR6(9), PHPT1(1), TYR(29)	12088037	126	104	124	23	12	55	25	15	19	0	0.0183	1.000	1.000
93	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(7), IFNGR1(7), JAK1(11), JAK2(16), PLA2G2A(5), PTPRU(19), REG1A(20), STAT1(7)	9229358	93	77	91	19	11	37	15	9	20	1	0.0404	1.000	1.000
94	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(7), CRY2(6), CSNK1E(6), PER1(10)	6788509	36	32	34	7	5	12	8	2	9	0	0.247	1.000	1.000
95	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(7), IFNGR1(7), IFNGR2(4), JAK1(11), JAK2(16), STAT1(7)	6617914	52	50	52	12	6	15	12	7	11	1	0.404	1.000	1.000
96	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(5), FARSB(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3), YARS2(10)	7030650	57	53	57	12	12	19	12	3	11	0	0.0918	1.000	1.000
97	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), ST3GAL3(4)	3992736	21	19	21	6	5	6	5	2	3	0	0.439	1.000	1.000
98	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(9), CSAD(6), GAD1(7), GAD2(27), GGT1(1)	4611376	50	45	50	14	4	22	10	4	10	0	0.387	1.000	1.000
99	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(3), CDC25A(4), CDC25B(1), CDC25C(8), CDK7(3), MNAT1(2), SHH(2), XPO1(12)	6942669	37	32	37	8	3	14	8	6	6	0	0.313	1.000	1.000
100	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(4), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8), MECR(2), PPT1(2), PPT2(1)	6827328	36	35	35	9	2	11	12	4	7	0	0.486	1.000	1.000
101	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(9), LPL(8), NR3C1(8), PPARG(8), RXRA(1), TNF(2)	4649244	36	35	36	10	3	14	8	3	7	1	0.359	1.000	1.000
102	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	EPO(6), FLT3(24), IGF1(4), IL1A(4), IL3(4), IL6(2), IL9(1), KITLG(6), TGFB1(3), TGFB2(10)	6569556	64	57	64	16	6	25	13	6	14	0	0.192	1.000	1.000
103	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5)	8379151	60	54	60	13	8	21	15	8	8	0	0.166	1.000	1.000
104	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5)	8379151	60	54	60	13	8	21	15	8	8	0	0.166	1.000	1.000
105	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(5), GNB1(2), GNGT1(6), HTR2C(11), PLCB1(56), TUB(11)	5767938	96	74	95	26	10	46	15	10	15	0	0.245	1.000	1.000
106	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(6), F13B(28), HSD17B1(2), HSD17B2(6), HSD17B3(3), HSD17B4(8), HSD17B7(3), HSD3B1(6), HSD3B2(15)	6540842	77	66	76	20	7	33	16	8	12	1	0.214	1.000	1.000
107	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(18), EGF(13), EGFR(87), GRB2(7), MET(22), PDGFRA(41), PRKCA(10), SH3GLB2(1), SH3KBP1(8), SRC(2)	15682674	219	169	167	44	18	57	34	42	67	1	0.0596	1.000	1.000
108	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), MIOX(2), UGDH(6)	6783953	44	39	44	11	4	18	12	4	6	0	0.283	1.000	1.000
109	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(5), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(3), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1)	5579121	46	40	46	11	5	20	8	3	9	1	0.300	1.000	1.000
110	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(11), BMPR1A(4), BMPR1B(7), BMPR2(10)	5050548	32	29	31	9	5	8	10	4	5	0	0.556	1.000	1.000
111	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(7), CHST11(2), CHST12(6), CHST13(3), PAPSS1(5), PAPSS2(10), SULT1A1(5), SULT1A2(5), SULT1E1(11), SULT2A1(6), SULT2B1(2), SUOX(5)	7381636	67	55	66	16	9	25	13	9	11	0	0.133	1.000	1.000
112	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(30), PIK3R1(4), PLCB1(56), PLCG1(7), PRKCA(10), VAV1(8)	10362726	118	93	106	26	10	59	22	10	17	0	0.0675	1.000	1.000
113	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(9), RAB27A(1), RAB4A(2), RAB5A(2), RAB6A(1)	3425847	15	14	15	9	1	5	5	3	1	0	0.974	1.000	1.000
114	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(4), AASS(20), KARS(8)	3810563	35	30	35	10	4	18	5	5	3	0	0.530	1.000	1.000
115	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(5), CD3D(2), CD3E(2), IFNG(7), IL2(7), IL2RA(6), IL4(1), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), TOB1(4), TOB2(4)	8525310	84	76	84	21	5	36	14	6	22	1	0.223	1.000	1.000
116	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(3), GH1(7), GHR(19), HRAS(2), IGF1(4), IGF1R(8), PIK3CA(30), PIK3R1(4), SHC1(6), SOD1(1), SOD2(6), SOD3(1)	10723295	94	84	82	21	5	49	19	7	14	0	0.0905	1.000	1.000
117	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(8), CSF1(1), HLA-DRA(3), HLA-DRB1(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), LTA(3), PDGFA(5), TGFB1(3), TGFB2(10), TNF(2)	10608184	93	81	89	23	4	42	12	13	21	1	0.183	1.000	1.000
118	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(8), DLL1(5), FURIN(7), NOTCH1(26), PSEN1(6)	6936866	52	47	52	13	13	14	7	7	11	0	0.156	1.000	1.000
119	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), DHFR(2), FPGS(3), GCH1(3), GGH(9), SPR(3)	5125898	49	42	49	15	2	16	14	5	12	0	0.462	1.000	1.000
120	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(2), ACYP2(1), ECHS1(4), EHHADH(13), GCDH(7), HADHA(3), SDHB(1), SDS(4)	6259671	37	33	35	10	6	11	9	5	6	0	0.448	1.000	1.000
121	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(8), ALOX15(5), ALOX15B(6), ALOX5(10), ALOX5AP(2), DPEP1(5), GGT1(1), LTA4H(3), PLA2G2A(5), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(19), PTGS2(12), TBXAS1(11)	11922131	106	87	103	22	20	37	22	13	14	0	0.0125	1.000	1.000
122	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(7), GBA3(1), GGT1(1), SHMT1(2), SHMT2(2)	4406742	16	16	16	6	2	5	5	1	3	0	0.794	1.000	1.000
123	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(6), CD3D(2), CD3E(2), CD4(8), CXCR3(3), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), JAK2(16), STAT4(11), TYK2(5)	11741422	89	72	89	19	7	36	15	10	20	1	0.0702	1.000	1.000
124	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(6), CD34(13), CD3D(2), CD3E(2), CD4(8), CD58(1), CD8A(4), IL3(4), IL6(2), KITLG(6)	4993395	48	39	47	16	4	21	6	4	13	0	0.544	1.000	1.000
125	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), CAMP(4), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7)	4773910	24	23	24	9	3	8	7	3	3	0	0.726	1.000	1.000
126	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(71), GLS(8), GLUD1(4), GOT1(3)	6263846	92	82	91	25	5	40	17	13	17	0	0.451	1.000	1.000
127	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(5), ELK1(3), FOS(3), GRB2(7), HRAS(2), JUN(3), KLK2(11), MAP2K1(10), MAPK3(3), MAPK8(2), NGFR(5), PIK3CA(30), PIK3R1(4), PLCG1(7), RAF1(6), SHC1(6), SOS1(17)	15412157	124	107	109	26	12	50	28	14	20	0	0.0566	1.000	1.000
128	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(3), CSNK1D(7), DRD1(13), DRD2(26), GRM1(48), PLCB1(56), PPP1CA(3), PPP1R1B(1), PPP2CA(1), PPP3CA(14), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	12833490	201	142	197	42	26	87	38	17	31	2	0.00340	1.000	1.000
129	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), GRB2(7), HRAS(2), PTK2B(14), SHC1(6), SOS1(17), SRC(2)	7080935	50	43	48	13	9	15	13	6	7	0	0.344	1.000	1.000
130	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), CREB1(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(6), MAPK3(3), NFKB1(6), PIK3CA(30), PIK3R1(4), RB1(33), RELA(3), SP1(6)	15605414	134	113	121	27	3	44	26	11	50	0	0.144	1.000	1.000
131	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(7), AKT3(8), CDKN1A(2), ELK1(3), GRB2(7), HRAS(2), MAP2K1(10), MAP2K2(1), NGFR(5), NTRK1(14), PIK3CA(30), PIK3CD(4), SHC1(6), SOS1(17)	12865991	119	100	104	27	11	53	30	12	12	1	0.0717	1.000	1.000
132	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(6), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PGK1(4), PKLR(16), RPE(3), RPIA(8), TKT(3), TPI1(9)	14454299	103	86	102	20	14	34	21	14	20	0	0.0196	1.000	1.000
133	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(11), ACVR1C(11), AKT1(3), AKT2(7), AKT3(8), ARRB1(2), ARRB2(4), ATF2(10), ATF4(2), BDNF(1), BRAF(44), CACNA1A(32), CACNA1B(41), CACNA1C(61), CACNA1D(22), CACNA1E(111), CACNA1F(30), CACNA1G(28), CACNA1H(21), CACNA1I(31), CACNA1S(23), CACNA2D1(49), CACNA2D3(24), CACNA2D4(25), CACNB1(5), CACNB2(24), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(6), CACNG3(18), CACNG4(6), CACNG5(13), CACNG6(11), CACNG7(9), CACNG8(5), CASP3(5), CD14(1), CDC25B(1), CDC42(2), CHUK(7), CRK(1), CRKL(4), DAXX(8), DDIT3(2), DUSP1(1), DUSP10(11), DUSP14(2), DUSP16(3), DUSP2(2), DUSP3(4), DUSP4(2), DUSP5(3), DUSP6(4), DUSP7(3), DUSP8(2), DUSP9(6), EGF(13), EGFR(87), ELK1(3), ELK4(6), FAS(4), FASLG(11), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF2(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FLNA(31), FLNB(16), FLNC(55), FOS(3), GADD45A(2), GADD45B(1), GADD45G(1), GNA12(2), GNG12(3), GRB2(7), HRAS(2), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), JUN(3), JUND(1), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(5), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(9), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK7(7), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAPT(15), MAX(8), MEF2C(6), MKNK1(4), MKNK2(2), MOS(9), MRAS(1), MYC(4), NF1(65), NFATC2(15), NFATC4(11), NFKB1(6), NFKB2(5), NLK(3), NR4A1(5), NRAS(4), NTF3(11), NTRK1(14), NTRK2(22), PAK1(9), PAK2(3), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PPM1A(6), PPM1B(9), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PPP5C(2), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTPN5(12), PTPN7(1), PTPRR(16), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(24), RASA1(11), RASA2(8), RASGRF1(11), RASGRF2(22), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KA6(19), RRAS(1), RRAS2(3), SOS1(17), SOS2(13), SRF(1), STK3(4), STK4(7), STMN1(2), TAOK1(8), TAOK2(13), TAOK3(9), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TP53(309), TRAF2(5), TRAF6(6), ZAK(12)	227344397	2667	516	2280	663	333	1019	498	272	532	13	5.43e-11	1.000	1.000
134	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(10), ACTG1(6), ACTN1(8), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(8), ARHGAP5(17), BAD(1), BCAR1(3), BCL2(5), BIRC2(2), BIRC3(4), BRAF(44), CAPN2(5), CAV1(1), CAV2(1), CAV3(3), CCND1(3), CCND2(4), CCND3(1), CDC42(2), CHAD(1), COL11A1(142), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(24), COL6A3(80), COL6A6(45), COMP(4), CRK(1), CRKL(4), CTNNB1(20), DIAPH1(3), DOCK1(15), EGF(13), EGFR(87), ELK1(3), ERBB2(12), FARP2(7), FIGF(4), FLNA(31), FLNB(16), FLNC(55), FLT1(31), FN1(26), FYN(9), GRB2(7), GSK3B(4), HGF(54), HRAS(2), IBSP(9), IGF1(4), IGF1R(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(10), ITGA4(39), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(7), ITGB3(17), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), JUN(3), KDR(56), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(41), LAMA5(33), LAMB1(41), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), MAP2K1(10), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MET(22), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), MYLPF(3), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARVA(3), PARVB(3), PARVG(8), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PDPK1(3), PGF(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PRKCA(10), PRKCG(20), PTEN(11), PTK2(6), PXN(2), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(7), RELN(104), RHOA(4), ROCK1(19), ROCK2(9), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SPP1(5), SRC(2), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TLN1(15), TLN2(31), TNC(26), TNN(87), TNR(112), TNXB(32), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCL(8), VEGFA(1), VEGFB(3), VEGFC(21), VTN(4), VWF(33), ZYX(6)	296509541	3322	504	3191	920	382	1424	611	278	609	18	9.14e-05	1.000	1.000
135	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(4), ACTN1(8), ACTN2(43), ACTN4(6), APC(33), APC2(8), ARAF(5), ARHGEF1(5), ARHGEF12(24), ARHGEF4(11), ARHGEF6(21), ARHGEF7(6), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), ARPC5(1), BAIAP2(4), BCAR1(3), BDKRB1(1), BDKRB2(3), BRAF(44), CD14(1), CDC42(2), CFL2(3), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CRK(1), CRKL(4), CSK(2), CYFIP1(12), CYFIP2(12), DIAPH1(3), DIAPH2(18), DIAPH3(16), DOCK1(15), EGF(13), EGFR(87), EZR(3), F2(9), F2R(10), FGD1(13), FGD3(8), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF2(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FN1(26), GIT1(3), GNA12(2), GNA13(6), GNG12(3), GSN(4), HRAS(2), IQGAP1(8), IQGAP2(31), IQGAP3(16), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(10), ITGA4(39), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(7), ITGB2(8), ITGB3(17), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), KRAS(169), LIMK1(3), LIMK2(4), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(9), MRAS(1), MSN(8), MYH10(14), MYH14(9), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), MYLPF(3), NCKAP1(11), NCKAP1L(24), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PFN1(1), PFN2(1), PFN4(2), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PPP1CA(3), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R12B(16), PTK2(6), PXN(2), RAC2(2), RAF1(6), RDX(2), RHOA(4), ROCK1(19), ROCK2(9), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(7), SOS1(17), SOS2(13), SSH1(10), SSH2(9), SSH3(9), TIAM1(59), TIAM2(22), VAV1(8), VAV2(8), VAV3(32), VCL(8), WAS(8), WASF1(10), WASF2(3), WASL(7)	220926006	2212	497	1944	583	246	923	454	201	381	7	6.75e-06	1.000	1.000
136	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY7(13), ADCY8(48), ADCY9(12), ADORA2A(3), ADORA2B(1), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), ATP2B4(13), AVPR1A(14), AVPR1B(7), BDKRB1(1), BDKRB2(3), BST1(3), CACNA1A(32), CACNA1B(41), CACNA1C(61), CACNA1D(22), CACNA1E(111), CACNA1F(30), CACNA1G(28), CACNA1H(21), CACNA1I(31), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CAMK4(16), CCKAR(14), CCKBR(24), CD38(4), CHRM1(5), CHRM2(39), CHRM3(27), CHRM5(6), CHRNA7(3), CYSLTR1(5), CYSLTR2(12), DRD1(13), EDNRA(3), EDNRB(17), EGFR(87), ERBB2(12), ERBB3(11), ERBB4(52), F2R(10), GNA11(4), GNA14(2), GNA15(1), GNAL(5), GNAQ(5), GNAS(29), GRIN1(9), GRIN2A(61), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(42), GRPR(7), HRH1(5), HRH2(17), HTR2A(6), HTR2B(5), HTR2C(11), HTR4(8), HTR5A(21), HTR6(10), HTR7(11), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), LHCGR(14), MYLK(26), MYLK2(9), NOS1(29), NOS3(12), NTSR1(10), OXTR(4), P2RX1(6), P2RX2(7), P2RX3(4), P2RX7(6), PDE1A(17), PDE1B(13), PDE1C(29), PDGFRA(41), PDGFRB(18), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PLCD1(5), PLCD3(2), PLCD4(7), PLCE1(29), PLCG1(7), PLCG2(18), PLCZ1(10), PLN(1), PPID(2), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTAFR(5), PTGER3(12), PTGFR(12), PTK2B(14), RYR1(111), RYR2(360), RYR3(124), SLC25A5(3), SLC25A6(5), SLC8A1(55), SLC8A2(10), SLC8A3(29), SPHK2(4), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), TNNC1(1), TNNC2(2), TRHR(14), TRPC1(10), VDAC1(2), VDAC2(2), VDAC3(1)	215110975	2930	486	2835	943	440	1176	591	270	435	18	0.00592	1.000	1.000
137	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(10), ABLIM1(4), ABLIM2(5), ABLIM3(18), ARHGEF12(24), CDC42(2), CDK5(3), CFL2(3), CXCL12(8), CXCR4(6), DCC(41), DPYSL2(3), DPYSL5(10), EFNA2(1), EFNA3(2), EFNB1(2), EFNB2(4), EFNB3(1), EPHA1(9), EPHA2(10), EPHA3(56), EPHA4(18), EPHA5(78), EPHA6(59), EPHA7(40), EPHA8(21), EPHB1(44), EPHB2(11), EPHB3(14), EPHB4(10), EPHB6(53), FES(1), FYN(9), GNAI1(10), GNAI2(1), GNAI3(2), GSK3B(4), HRAS(2), ITGB1(7), KRAS(169), L1CAM(42), LIMK1(3), LIMK2(4), LRRC4C(53), MAPK1(2), MAPK3(3), MET(22), NCK1(5), NCK2(6), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NGEF(12), NRAS(4), NRP1(9), NTN1(1), NTN4(6), NTNG1(34), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLXNA1(16), PLXNA2(30), PLXNA3(20), PLXNB1(12), PLXNB2(21), PLXNB3(15), PLXNC1(11), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PTK2(6), RAC2(2), RASA1(11), RGS3(14), RHOA(4), RHOD(2), ROBO1(31), ROBO2(54), ROBO3(19), ROCK1(19), ROCK2(9), SEMA3A(26), SEMA3C(15), SEMA3D(33), SEMA3E(15), SEMA3F(7), SEMA3G(6), SEMA4A(5), SEMA4B(2), SEMA4C(7), SEMA4D(8), SEMA4F(12), SEMA4G(3), SEMA5A(59), SEMA5B(30), SEMA6A(20), SEMA6B(12), SEMA6C(10), SEMA6D(40), SEMA7A(9), SLIT1(20), SLIT2(61), SLIT3(41), SRGAP1(20), SRGAP2(7), SRGAP3(24), UNC5A(18), UNC5B(19), UNC5C(22), UNC5D(45)	156945236	2044	464	1846	551	264	917	359	164	333	7	2.02e-07	1.000	1.000
138	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(17), ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA2A(3), ADRA2B(4), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), C5AR1(7), CALCR(27), CALCRL(18), CCKAR(14), CCKBR(24), CGA(2), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CRHR1(9), CTSG(12), CYSLTR1(5), CYSLTR2(12), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(17), F2(9), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHB(4), FSHR(37), GABBR1(8), GABBR2(13), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GABRB1(21), GABRB2(10), GABRB3(41), GABRD(8), GABRE(7), GABRG1(34), GABRG2(37), GABRG3(28), GABRP(6), GABRQ(23), GABRR1(11), GABRR2(10), GALR1(8), GALR2(3), GALR3(1), GH1(7), GH2(14), GHR(19), GHRHR(7), GHSR(6), GIPR(3), GLP1R(11), GLP2R(17), GLRA1(10), GLRA2(23), GLRA3(9), GLRB(9), GNRHR(7), GPR156(16), GPR35(8), GPR50(21), GPR63(10), GPR83(12), GRIA1(19), GRIA2(28), GRIA3(24), GRIA4(27), GRID1(30), GRID2(54), GRIK1(31), GRIK2(41), GRIK3(23), GRIK4(25), GRIK5(15), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRIN3A(38), GRIN3B(6), GRM1(48), GRM2(7), GRM3(20), GRM4(21), GRM5(42), GRM6(17), GRM7(44), GRM8(53), GRPR(7), GZMA(8), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HRH4(5), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(11), HTR4(8), HTR5A(21), HTR6(10), HTR7(11), LEP(4), LEPR(26), LHB(3), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), MCHR1(4), MCHR2(16), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPBWR1(5), NPBWR2(8), NPFFR1(2), NPFFR2(22), NPY1R(17), NPY2R(20), NPY5R(22), NR3C1(8), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(16), OXTR(4), P2RX1(6), P2RX2(7), P2RX3(4), P2RX7(6), P2RY1(4), P2RY10(23), P2RY13(1), P2RY14(2), P2RY2(3), P2RY4(4), P2RY6(2), P2RY8(9), PARD3(15), PRL(3), PRLHR(9), PRLR(18), PRSS1(25), PRSS3(1), PTAFR(5), PTGDR(8), PTGER2(4), PTGER3(12), PTGER4(7), PTGFR(12), PTGIR(6), PTH2R(15), RXFP1(20), RXFP2(8), SCTR(5), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SSTR5(6), TAAR1(5), TAAR2(9), TAAR5(11), TAAR6(15), TAAR8(9), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), THRA(6), THRB(4), TRHR(14), TRPV1(5), TSHB(5), TSHR(22), UTS2R(4), VIPR1(2), VIPR2(3)	177489602	2962	458	2927	1012	401	1294	605	263	390	9	0.0115	1.000	1.000
139	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRB1(1), CSNK1D(7), DRD1(13), DRD2(26), EGF(13), EGFR(87), GJA1(11), GJD2(6), GNA11(4), GNAI1(10), GNAI2(1), GNAI3(2), GNAQ(5), GNAS(29), GRB2(7), GRM1(48), GRM5(42), GUCY1A2(29), GUCY1A3(16), GUCY1B3(11), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), HTR2A(6), HTR2B(5), HTR2C(11), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K5(4), MAP3K2(6), MAPK1(2), MAPK3(3), MAPK7(7), NPR1(16), NPR2(6), NRAS(4), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), PRKX(3), RAF1(6), SOS1(17), SOS2(13), SRC(2), TJP1(15), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB2C(1), TUBB3(3), TUBB6(3), TUBB8(18)	105965928	1390	455	1169	357	157	594	279	139	217	4	5.33e-06	1.000	1.000
140	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(33), APC2(8), AXIN1(7), AXIN2(5), BTRC(12), CACYBP(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CCND1(3), CCND2(4), CCND3(1), CER1(7), CHD8(29), CREBBP(30), CSNK1A1(2), CSNK1A1L(14), CSNK1E(6), CSNK2A1(5), CSNK2A2(2), CTBP1(3), CTBP2(6), CTNNB1(20), CUL1(14), CXXC4(2), DAAM1(8), DAAM2(4), DKK1(3), DKK2(14), DKK4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), FBXW11(2), FOSL1(4), FZD1(6), FZD10(30), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LEF1(12), LRP5(17), LRP6(16), MAP3K7(10), MAPK10(6), MAPK8(2), MAPK9(8), MMP7(7), MYC(4), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NKD1(6), NKD2(8), NLK(3), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PORCN(7), PPARD(6), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(13), PPP2R2C(6), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRICKLE1(11), PRICKLE2(9), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PSEN1(6), RAC2(2), RHOA(4), ROCK1(19), ROCK2(9), RUVBL1(4), SENP2(6), SFRP1(3), SFRP2(6), SFRP4(7), SFRP5(1), SIAH1(1), SKP1(4), SMAD2(7), SMAD3(7), SMAD4(23), SOX17(1), TBL1X(5), TBL1XR1(6), TBL1Y(1), TCF7(3), TCF7L1(6), TCF7L2(7), TP53(309), VANGL1(9), VANGL2(15), WIF1(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(11), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6)	128954943	1430	447	1276	323	227	498	250	136	314	5	2.45e-09	1.000	1.000
141	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(10), ACTG1(6), ACTN1(8), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(8), AMOTL1(11), ASH1L(33), CASK(8), CDC42(2), CDK4(3), CGN(12), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(6), CLDN9(2), CSNK2A1(5), CSNK2A2(2), CTNNA1(10), CTNNA2(66), CTNNA3(22), CTNNB1(20), CTTN(7), EPB41(2), EPB41L1(10), EPB41L2(16), EPB41L3(32), EXOC3(3), EXOC4(16), F11R(3), GNAI1(10), GNAI2(1), GNAI3(2), HCLS1(17), HRAS(2), IGSF5(6), INADL(20), JAM2(9), JAM3(4), KRAS(169), LLGL1(6), LLGL2(9), MAGI1(21), MAGI2(33), MAGI3(10), MLLT4(12), MPDZ(20), MPP5(2), MRAS(1), MYH1(70), MYH10(14), MYH11(28), MYH13(47), MYH14(9), MYH15(31), MYH2(77), MYH3(37), MYH4(53), MYH6(42), MYH7(59), MYH7B(13), MYH8(73), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLPF(3), NRAS(4), OCLN(1), PARD3(15), PARD6A(1), PARD6B(5), PARD6G(2), PPM1J(3), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(13), PPP2R2C(6), PPP2R3A(5), PPP2R3B(6), PPP2R4(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PTEN(11), RAB13(1), RAB3B(1), RHOA(4), RRAS(1), RRAS2(3), SPTAN1(21), SRC(2), SYMPK(16), TJAP1(4), TJP1(15), TJP2(6), TJP3(6), VAPA(2), YES1(3), ZAK(12)	155527927	1656	447	1476	430	196	730	345	129	252	4	9.30e-06	1.000	1.000
142	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ATF4(2), CACNA1C(61), CACNA1D(22), CACNA1F(30), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CDC42(2), CGA(2), EGFR(87), ELK1(3), FSHB(4), GNA11(4), GNAQ(5), GNAS(29), GNRH1(1), GNRHR(7), GRB2(7), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), KRAS(169), LHB(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK7(7), MAPK8(2), MAPK9(8), MMP14(4), MMP2(24), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PLD1(22), PLD2(7), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCD(7), PRKX(3), PTK2B(14), RAF1(6), SOS1(17), SOS2(13), SRC(2)	101702499	1228	445	1007	317	157	522	234	112	202	1	2.59e-05	1.000	1.000
143	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(10), ACTG1(6), CHAD(1), COL11A1(142), COL11A2(21), COL17A1(16), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(24), COL6A3(80), COL6A6(45), COMP(4), DES(4), DSC1(16), DSC2(24), DSC3(24), DSG1(29), DSG2(12), DSG3(37), DSG4(31), FN1(26), GJA1(11), GJA10(15), GJA3(3), GJA4(6), GJA5(7), GJA8(18), GJA9(12), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GJB7(6), GJC1(8), GJC2(5), GJC3(4), GJD2(6), GJD4(3), IBSP(9), INA(4), ITGA6(12), ITGB4(10), KRT1(11), KRT10(6), KRT12(8), KRT13(5), KRT14(11), KRT15(4), KRT16(8), KRT17(2), KRT19(6), KRT2(11), KRT20(5), KRT23(7), KRT24(9), KRT25(11), KRT27(3), KRT28(11), KRT3(9), KRT31(14), KRT32(3), KRT33A(7), KRT33B(7), KRT34(15), KRT35(11), KRT36(9), KRT37(14), KRT38(15), KRT39(5), KRT4(9), KRT40(7), KRT5(14), KRT6A(14), KRT6B(19), KRT6C(5), KRT7(9), KRT71(12), KRT72(14), KRT73(10), KRT74(11), KRT75(11), KRT76(4), KRT77(6), KRT78(6), KRT79(12), KRT8(3), KRT81(2), KRT82(12), KRT83(9), KRT84(5), KRT85(5), KRT86(1), KRT9(5), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(41), LAMA5(33), LAMB1(41), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), LMNA(2), LMNB1(5), LMNB2(5), NES(33), PRPH(1), RELN(104), SPP1(5), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNR(112), TNXB(32), VIM(5), VTN(4), VWF(33)	199332373	2525	444	2499	785	316	1117	478	163	437	14	0.0931	1.000	1.000
144	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(7), ACVR1B(11), ACVR2A(5), ACVR2B(4), AMHR2(6), BMP2(1), BMP7(14), BMPR1A(4), BMPR1B(7), BMPR2(10), CCL1(4), CCL11(2), CCL13(3), CCL14(5), CCL15(5), CCL16(4), CCL17(3), CCL18(2), CCL19(1), CCL2(2), CCL20(3), CCL21(2), CCL22(1), CCL23(4), CCL24(1), CCL25(2), CCL28(6), CCL4(2), CCL7(7), CCL8(1), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CCR9(1), CD27(1), CD40(3), CD40LG(9), CD70(1), CNTF(6), CNTFR(5), CRLF2(9), CSF1(1), CSF1R(18), CSF2RA(11), CSF2RB(14), CSF3R(7), CX3CL1(5), CX3CR1(12), CXCL1(1), CXCL10(1), CXCL11(1), CXCL12(8), CXCL14(1), CXCL16(1), CXCL2(1), CXCL6(3), CXCL9(4), CXCR3(3), CXCR4(6), CXCR6(2), EDA(4), EDA2R(9), EDAR(10), EGF(13), EGFR(87), EPO(6), EPOR(2), FAS(4), FASLG(11), FLT1(31), FLT3(24), FLT3LG(2), FLT4(20), GDF5(12), GH1(7), GH2(14), GHR(19), HGF(54), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL15(6), IL15RA(2), IL17A(12), IL17B(2), IL17RA(4), IL18R1(12), IL18RAP(22), IL19(2), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL1RAP(4), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL25(2), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(10), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(20), INHBA(31), INHBB(4), INHBC(4), INHBE(5), KDR(56), KIT(12), KITLG(6), LEP(4), LEPR(26), LIF(3), LIFR(14), LTA(3), LTB(4), LTBR(1), MET(22), MPL(6), NGFR(5), OSM(5), OSMR(7), PDGFB(2), PDGFC(3), PDGFRA(41), PDGFRB(18), PF4(1), PF4V1(2), PLEKHO2(3), PPBP(2), PRL(3), PRLR(18), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(9), TNFRSF11B(3), TNFRSF12A(4), TNFRSF13B(3), TNFRSF13C(2), TNFRSF14(1), TNFRSF18(2), TNFRSF19(5), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(11), TNFRSF9(7), TNFSF10(3), TNFSF11(5), TNFSF13B(1), TNFSF14(2), TNFSF15(3), TNFSF18(5), TNFSF4(2), TNFSF8(1), TNFSF9(3), TPO(35), TSLP(8), VEGFA(1), VEGFB(3), VEGFC(21), XCL1(7), XCL2(5), XCR1(6)	142290090	1540	434	1473	423	154	624	297	187	276	2	0.00406	1.000	1.000
145	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), ANXA6(8), ARRB1(2), ARRB2(4), ATP1A4(19), ATP1B1(6), ATP1B2(1), ATP1B3(3), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), CACNA1A(32), CACNA1B(41), CACNA1C(61), CACNA1D(22), CACNA1E(111), CACNA1S(23), CACNB1(5), CACNB3(1), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CAMK4(16), CASQ1(6), CASQ2(5), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), FXYD2(1), GJA1(11), GJA4(6), GJA5(7), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GNA11(4), GNAI2(1), GNAI3(2), GNAO1(9), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), ITPR1(20), ITPR2(40), ITPR3(21), KCNB1(28), KCNJ3(36), KCNJ5(10), MIB1(12), NME7(4), PEA15(1), PKIA(1), PKIB(2), PKIG(1), PLCB3(9), PLN(1), PRKACA(3), PRKACB(11), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RGS1(15), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(14), RGS4(8), RGS5(7), RGS6(14), RGS7(33), RGS9(16), RYR1(111), RYR2(360), RYR3(124), SFN(1), SLC8A1(55), SLC8A3(29), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4)	150352635	2091	431	2060	681	302	875	429	179	289	17	0.0342	1.000	1.000
146	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(16), CD36(4), CD44(7), CD47(6), CHAD(1), COL11A1(142), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(24), COL6A3(80), COL6A6(45), DAG1(3), FN1(26), FNDC1(33), FNDC3A(9), FNDC4(1), FNDC5(1), GP5(8), GP6(7), HMMR(6), HSPG2(33), IBSP(9), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(10), ITGA4(39), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(7), ITGB3(17), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(41), LAMA5(33), LAMB1(41), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), RELN(104), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SPP1(5), SV2A(17), SV2B(14), SV2C(20), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNR(112), TNXB(32), VTN(4), VWF(33)	178940152	2179	431	2160	620	251	986	418	125	384	15	0.00519	1.000	1.000
147	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(10), ABL2(19), AKT1(3), AKT2(7), AKT3(8), ARAF(5), AREG(1), BAD(1), BRAF(44), BTC(2), CAMK2A(3), CAMK2B(16), CAMK2D(8), CBL(10), CBLB(10), CBLC(1), CDKN1A(2), CDKN1B(5), CRK(1), CRKL(4), EGF(13), EGFR(87), ELK1(3), ERBB2(12), ERBB3(11), ERBB4(52), EREG(4), GAB1(7), GRB2(7), GSK3B(4), HRAS(2), JUN(3), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MYC(4), NCK1(5), NCK2(6), NRAS(4), NRG1(22), NRG2(3), NRG3(31), NRG4(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SRC(2), STAT5A(3), STAT5B(8), TGFA(1)	82290086	981	429	719	209	104	436	184	93	162	2	2.87e-07	1.000	1.000
148	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(26), ADCY8(48), ARAF(5), ATF4(2), BRAF(44), CACNA1C(61), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CAMK4(16), CREBBP(30), EP300(11), GNAQ(5), GRIA1(19), GRIA2(28), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(42), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NRAS(4), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PPP1CA(3), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(19)	79663693	1101	427	906	267	131	526	226	73	141	4	2.84e-07	1.000	1.000
149	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(10), ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), ATM(53), ATR(26), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(10), CDC14B(3), CDC16(2), CDC20(8), CDC23(4), CDC25A(4), CDC25B(1), CDC25C(8), CDC27(7), CDC6(4), CDC7(6), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(23), CDKN2D(2), CHEK1(7), CHEK2(10), CREBBP(30), CUL1(14), DBF4(6), E2F1(3), E2F2(5), E2F3(2), EP300(11), ESPL1(6), FZR1(3), GADD45A(2), GADD45B(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(8), MAD1L1(7), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), PCNA(1), PKMYT1(3), PLK1(9), PRKDC(50), PTTG1(2), PTTG2(3), RB1(33), RBL1(7), RBL2(5), SFN(1), SKP1(4), SKP2(4), SMAD2(7), SMAD3(7), SMAD4(23), SMC1A(9), SMC1B(8), TFDP1(11), TGFB1(3), TGFB2(10), TP53(309), WEE1(4), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	109028105	1043	420	900	156	138	301	183	120	295	6	<1.00e-15	1.000	1.000
150	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(21), ACACB(28), AKT1(3), AKT2(7), AKT3(8), ARAF(5), BAD(1), BRAF(44), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CBL(10), CBLB(10), CBLC(1), CRK(1), CRKL(4), ELK1(3), EXOC7(4), FASN(18), FBP1(2), FBP2(2), FLOT1(1), FLOT2(4), FOXO1(5), G6PC(7), G6PC2(8), GCK(7), GRB2(7), GSK3B(4), GYS1(4), GYS2(8), HRAS(2), IKBKB(9), INPP5D(12), INSR(10), IRS1(20), IRS4(34), KRAS(169), LIPE(5), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MKNK1(4), MKNK2(2), NRAS(4), PCK1(22), PCK2(4), PDE3A(30), PDE3B(16), PDPK1(3), PFKL(9), PFKM(7), PFKP(6), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PKLR(16), PPARGC1A(24), PPP1CA(3), PPP1CB(4), PPP1CC(1), PPP1R3A(48), PPP1R3B(1), PPP1R3C(3), PPP1R3D(5), PRKAA1(7), PRKAA2(8), PRKAB1(3), PRKACA(3), PRKACB(11), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAG3(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCI(11), PRKCZ(4), PRKX(3), PTPN1(3), PTPRF(15), PYGB(5), PYGL(6), PYGM(9), RAF1(6), RAPGEF1(7), RHEB(4), RHOQ(1), RPS6(3), RPS6KB1(3), RPS6KB2(3), SH2B2(6), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(12), SOS1(17), SOS2(13), SREBF1(5), TRIP10(4), TSC1(10), TSC2(13)	126813403	1156	419	953	318	140	520	244	95	153	4	0.00321	1.000	1.000
151	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(5), BID(2), BRAF(44), CASP3(5), CD244(14), CD247(1), CD48(6), FAS(4), FASLG(11), FCER1G(2), FCGR3A(7), FCGR3B(12), FYN(9), GRB2(7), GZMB(8), HCST(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-E(2), HLA-G(5), HRAS(2), ICAM1(2), ICAM2(2), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), ITGAL(26), ITGB2(8), KIR2DL1(13), KIR2DL3(8), KIR2DL4(4), KIR3DL1(17), KIR3DL2(5), KLRC1(5), KLRC2(4), KLRC3(3), KLRD1(2), KLRK1(4), KRAS(169), LAT(4), LCK(13), LCP2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(9), NCR2(3), NCR3(1), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NRAS(4), PAK1(9), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRF1(8), PRKCA(10), PRKCG(20), PTK2B(14), PTPN11(9), PTPN6(6), RAC2(2), RAF1(6), SH2D1A(3), SH2D1B(3), SH3BP2(10), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SYK(5), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TYROBP(2), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(8), VAV2(8), VAV3(32), ZAP70(9)	90825368	1070	418	860	238	116	498	223	87	142	4	1.92e-08	1.000	1.000
152	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(5), BRAF(44), CACNA1A(32), CRH(3), CRHR1(9), GNA11(4), GNA12(2), GNA13(6), GNAI1(10), GNAI2(1), GNAI3(2), GNAO1(9), GNAQ(5), GNAS(29), GNAZ(5), GRIA1(19), GRIA2(28), GRIA3(24), GRID2(54), GRM1(48), GRM5(42), GUCY1A2(29), GUCY1A3(16), GUCY1B3(11), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), IGF1(4), IGF1R(8), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(29), NOS3(12), NPR1(16), NPR2(6), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(13), PPP2R2C(6), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), RAF1(6), RYR1(111)	88226661	1225	414	1034	297	155	557	246	91	171	5	3.11e-08	1.000	1.000
153	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(10), ATM(53), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(8), CDC14A(10), CDC14B(3), CDC20(8), CDC25A(4), CDC25B(1), CDC25C(8), CDC6(4), CDC7(6), CDH1(6), CDK2(1), CDK4(3), CDKN1A(2), CDKN2A(23), CHEK1(7), CHEK2(10), DTX4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), EP300(11), ESPL1(6), GADD45A(2), GSK3B(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), HDAC8(2), MAD1L1(7), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MPEG1(12), MPL(6), PCNA(1), PLK1(9), PRKDC(50), PTPRA(11), PTTG1(2), PTTG2(3), RB1(33), RBL1(7), SKP2(4), SMAD4(23), TBC1D8(9), TFDP1(11), TGFB1(3), TP53(309), WEE1(4)	88375531	929	407	786	135	115	273	149	103	283	6	<1.00e-15	1.000	1.000
154	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(9), ACTA2(1), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADM(2), ARRB1(2), ARRB2(4), ATF1(1), ATF2(10), ATF4(2), ATF5(2), ATP2A2(12), ATP2A3(7), CACNB3(1), CALCA(9), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CNN1(5), CORIN(26), CREB3(1), CRH(3), CRHR1(9), DGKZ(5), ETS2(6), FOS(3), GABPA(6), GABPB2(1), GBA2(5), GJA1(11), GNAQ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), GUCA2B(2), GUCY1A3(16), IGFBP1(6), IGFBP2(4), IGFBP3(4), IGFBP4(1), IGFBP6(1), IL1B(1), IL6(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), MIB1(12), MYL2(8), MYL4(2), MYLK2(9), NFKB1(6), NOS1(29), NOS3(12), OXT(2), OXTR(4), PDE4B(17), PDE4D(8), PKIA(1), PKIB(2), PKIG(1), PLCB3(9), PLCD1(5), PLCG1(7), PLCG2(18), PRKACA(3), PRKACB(11), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RAMP1(1), RAMP2(4), RAMP3(3), RGS1(15), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(14), RGS4(8), RGS5(7), RGS6(14), RGS7(33), RGS9(16), RYR1(111), RYR2(360), RYR3(124), SFN(1), SLC8A1(55), SP1(6), TNXB(32), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4)	138778548	1675	407	1652	547	227	696	346	148	244	14	0.177	1.000	1.000
155	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(7), CADM1(7), CADM3(15), CD2(6), CD22(16), CD226(14), CD274(3), CD276(2), CD28(5), CD34(13), CD4(8), CD40(3), CD40LG(9), CD58(1), CD6(13), CD80(3), CD86(11), CD8A(4), CD8B(5), CD99(3), CDH1(6), CDH15(9), CDH2(39), CDH3(7), CDH4(23), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(6), CLDN9(2), CNTN1(37), CNTN2(18), CNTNAP1(11), CNTNAP2(88), CTLA4(3), ESAM(2), F11R(3), GLG1(17), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(5), ICOSLG(3), ITGA4(39), ITGA6(12), ITGA8(59), ITGA9(6), ITGAL(26), ITGAM(24), ITGAV(14), ITGB1(7), ITGB2(8), ITGB7(2), ITGB8(15), JAM2(9), JAM3(4), L1CAM(42), MADCAM1(2), MAG(7), MPZ(2), MPZL1(3), NCAM1(30), NCAM2(28), NEGR1(14), NEO1(12), NFASC(46), NLGN1(34), NLGN2(10), NLGN3(14), NRCAM(36), NRXN1(115), NRXN2(26), NRXN3(49), OCLN(1), PDCD1(4), PDCD1LG2(4), PTPRC(41), PTPRF(15), PTPRM(14), PVR(2), PVRL1(17), PVRL3(7), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SELE(17), SELL(9), SELP(29), SELPLG(2), SIGLEC1(18), SPN(4), VCAM1(28), VCAN(104)	118538695	1572	406	1551	462	200	697	306	124	237	8	0.00387	1.000	1.000
156	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(7), AKT3(8), BCL10(4), CARD11(34), CBL(10), CBLB(10), CBLC(1), CD247(1), CD28(5), CD3D(2), CD3E(2), CD4(8), CD40LG(9), CD8A(4), CD8B(5), CDC42(2), CDK4(3), CHUK(7), CTLA4(3), FOS(3), FYN(9), GRAP2(13), GRB2(7), HRAS(2), ICOS(5), IFNG(7), IKBKB(9), IL10(2), IL2(7), IL4(1), IL5(2), ITK(16), JUN(3), KRAS(169), LAT(4), LCK(13), LCP2(10), MALT1(13), MAP3K8(5), NCK1(5), NCK2(6), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDCD1(4), PDK1(6), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRKCQ(12), PTPN6(6), PTPRC(41), RASGRP1(3), RHOA(4), SOS1(17), SOS2(13), TEC(12), TNF(2), VAV1(8), VAV2(8), VAV3(32), ZAP70(9)	81304899	926	405	742	202	113	439	170	62	140	2	2.61e-07	1.000	1.000
157	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ASIP(1), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CREB1(2), CREB3(1), CREB3L1(4), CREB3L2(11), CREB3L3(4), CREB3L4(2), CREBBP(30), CTNNB1(20), DCT(16), DVL1(5), DVL2(7), DVL3(13), EDN1(1), EDNRB(17), EP300(11), FZD1(6), FZD10(30), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GNAI1(10), GNAI2(1), GNAI3(2), GNAO1(9), GNAQ(5), GNAS(29), GSK3B(4), HRAS(2), KIT(12), KITLG(6), KRAS(169), LEF1(12), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MC1R(2), MITF(3), NRAS(4), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), POMC(4), PRKACA(3), PRKACB(11), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), TCF7(3), TCF7L1(6), TCF7L2(7), TYR(29), TYRP1(5), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(11), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6)	86816850	1092	399	913	298	166	488	225	73	138	2	2.60e-05	1.000	1.000
158	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(17), AKT1(3), AKT2(7), AKT3(8), APAF1(10), ATM(53), BAD(1), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CAPN1(2), CAPN2(5), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(14), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(11), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL3(4), IL3RA(8), IRAK1(6), IRAK2(6), IRAK3(6), IRAK4(4), MYD88(3), NFKB1(6), NFKB2(5), NFKBIA(4), NTRK1(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRKACA(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TP53(309), TRADD(2), TRAF2(5)	66856063	800	398	649	157	97	261	145	92	198	7	1.76e-07	1.000	1.000
159	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), AKAP1(14), AKAP10(4), AKAP11(14), AKAP12(9), AKAP2(1), AKAP3(15), AKAP4(17), AKAP5(2), AKAP6(45), AKAP7(1), AKAP8(5), AKAP9(33), ARHGEF1(5), CALM1(3), CALM2(1), CHMP1B(1), GNA11(4), GNA12(2), GNA13(6), GNA14(2), GNA15(1), GNAI2(1), GNAI3(2), GNAL(5), GNAO1(9), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB5(7), GNG12(3), GNG13(5), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GNGT2(3), HRAS(2), IL18BP(1), ITPR1(20), KCNJ3(36), KRAS(169), NRAS(4), PALM2(7), PDE1A(17), PDE1B(13), PDE1C(29), PDE4A(8), PDE4B(17), PDE4C(4), PDE4D(8), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PLCB3(9), PPP3CA(14), PPP3CC(3), PRKACA(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(7), USP5(8)	93920207	1001	388	833	280	112	468	219	74	123	5	0.00675	1.000	1.000
160	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CCR9(1), CCRL2(2), CHML(12), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CMKLR1(24), CNR1(15), CNR2(3), CX3CR1(12), CXCR3(3), CXCR4(6), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(17), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(6), GNB2L1(3), GPR17(8), GPR173(4), GPR174(18), GPR27(5), GPR35(8), GPR37(17), GPR4(7), GPR50(21), GPR6(8), GPR63(10), GPR83(12), GPR85(16), GPR87(4), GRPR(7), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(11), HTR4(8), HTR5A(21), HTR6(10), HTR7(11), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC3R(16), MC4R(3), MC5R(22), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPN1SW(8), OPN3(3), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(16), OR10A5(14), OR11A1(8), OR12D3(4), OR1C1(29), OR1F1(3), OR1Q1(11), OR2H1(16), OR5V1(6), OR7A5(6), OR7C1(5), OR8B8(12), OXTR(4), P2RY1(4), P2RY10(23), P2RY12(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY6(2), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), RGR(4), RHO(7), RRH(2), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SUCNR1(1), TBXA2R(1), TRHR(14)	97389921	1437	388	1417	498	221	602	313	146	151	4	0.00614	1.000	1.000
161	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(5), ACTB(10), ACTG1(6), ACTN1(8), ACTN2(43), ACTN4(6), ACVR1B(11), ACVR1C(11), BAIAP2(4), CDC42(2), CDH1(6), CREBBP(30), CSNK2A1(5), CSNK2A2(2), CTNNA1(10), CTNNA2(66), CTNNA3(22), CTNNB1(20), CTNND1(10), EGFR(87), EP300(11), ERBB2(12), FARP2(7), FER(16), FGFR1(4), FYN(9), IGF1R(8), INSR(10), IQGAP1(8), LEF1(12), LMO7(22), MAP3K7(10), MAPK1(2), MAPK3(3), MET(22), MLLT4(12), NLK(3), PARD3(15), PTPN1(3), PTPN6(6), PTPRB(58), PTPRF(15), PTPRJ(12), PTPRM(14), PVRL1(17), PVRL3(7), PVRL4(9), RAC2(2), RHOA(4), SMAD2(7), SMAD3(7), SMAD4(23), SNAI1(3), SNAI2(14), SORBS1(12), SRC(2), SSX2IP(3), TCF7(3), TCF7L1(6), TCF7L2(7), TGFBR1(7), TGFBR2(7), TJP1(15), VCL(8), WAS(8), WASF1(10), WASF2(3), WASF3(14), WASL(7), YES1(3)	96545997	866	383	797	210	112	288	164	107	195	0	0.00155	1.000	1.000
162	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(7), AKT3(8), BCL10(4), BLNK(2), BTK(25), CARD11(34), CD19(5), CD22(16), CD72(2), CD79A(2), CD79B(2), CD81(1), CHUK(7), CR2(20), FCGR2B(7), FOS(3), GSK3B(4), HRAS(2), IFITM1(2), IKBKB(9), INPP5D(12), JUN(3), KRAS(169), LILRB3(7), LYN(6), MALT1(13), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG2(18), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PTPN6(6), RAC2(2), RASGRP3(11), SYK(5), VAV1(8), VAV2(8), VAV3(32)	59550819	695	375	518	156	66	349	147	44	88	1	6.07e-06	1.000	1.000
163	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(7), ACVR1B(11), ACVRL1(12), AKT1(3), AURKB(2), BMPR1A(4), BMPR2(10), BUB1(10), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(4), CLK1(3), CLK2(10), CLK4(4), COL4A3BP(3), CSNK2A1(5), CSNK2A2(2), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), IMPA1(2), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MAP3K10(4), MOS(9), NEK1(11), NEK3(4), OCRL(13), PAK4(6), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CA(30), PIK3CB(8), PIK3CG(33), PIM2(7), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PLCD1(5), PLCG1(7), PLCG2(18), PLK3(4), PRKACA(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKG1(20), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KB1(3), STK11(87), TGFBR1(7), VRK1(6)	90226248	863	375	828	211	108	318	169	82	182	4	0.00363	1.000	1.000
164	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADK(2), ADSL(2), ADSS(6), ADSSL1(4), AK2(4), AK5(14), AK7(13), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), FHIT(2), GART(9), GDA(12), GMPR(5), GMPR2(2), GMPS(9), GUCY1A2(29), GUCY1A3(16), GUCY1B3(11), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(3), HPRT1(1), IMPDH1(7), IMPDH2(4), ITPA(1), NME6(3), NME7(4), NPR1(16), NPR2(6), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5C3(1), NT5E(5), NT5M(3), NUDT2(3), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(5), PAPSS2(10), PDE10A(31), PDE11A(24), PDE1A(17), PDE1C(29), PDE2A(11), PDE3B(16), PDE4A(8), PDE4B(17), PDE4C(4), PDE4D(8), PDE5A(8), PDE6G(3), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PDE9A(10), PFAS(9), PKLR(16), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PPAT(1), PRIM1(3), PRIM2(14), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), XDH(18), ZNRD1(1)	130985627	1099	374	1093	346	124	419	256	113	184	3	0.400	1.000	1.000
165	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(9), ACTA2(1), ACTN2(43), ACTN4(6), DES(4), DMD(108), MYBPC1(21), MYBPC2(8), MYBPC3(15), MYH3(37), MYH6(42), MYH7(59), MYH8(73), MYL1(4), MYL2(8), MYL3(4), MYL4(2), MYL9(3), MYOM1(16), NEB(94), TCAP(1), TMOD1(5), TNNC2(2), TNNI1(3), TNNI2(4), TNNI3(7), TNNT1(3), TNNT2(6), TNNT3(5), TPM1(2), TPM2(4), TPM3(2), TPM4(3), TTN(717), VIM(5)	110040676	1326	374	1312	386	135	565	316	137	156	17	0.607	1.000	1.000
166	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), AKT2(7), AKT3(8), BCL2L1(3), CBL(10), CBLB(10), CBLC(1), CCND1(3), CCND2(4), CCND3(1), CISH(1), CNTF(6), CNTFR(5), CREBBP(30), CRLF2(9), CSF2RA(11), CSF2RB(14), CSF3R(7), EP300(11), EPO(6), EPOR(2), GH1(7), GH2(14), GHR(19), GRB2(7), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL13RA2(13), IL15(6), IL15RA(2), IL19(2), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(10), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(20), IRF9(9), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), LIF(3), LIFR(14), MPL(6), MYC(4), OSM(5), OSMR(7), PIAS1(2), PIAS2(6), PIAS3(7), PIAS4(2), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIM1(1), PRL(3), PRLR(18), PTPN11(9), PTPN6(6), SOCS2(3), SOCS4(1), SOCS5(8), SOCS7(2), SOS1(17), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), STAM(11), STAM2(5), STAT1(7), STAT2(6), STAT3(11), STAT4(11), STAT5A(3), STAT5B(8), STAT6(2), TPO(35), TSLP(8), TYK2(5)	116625933	1001	372	985	303	98	403	221	107	171	1	0.565	1.000	1.000
167	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(7), AKT3(8), BTK(25), FCER1A(9), FCER1G(2), FYN(9), GAB2(7), GRB2(7), HRAS(2), IL13(2), IL3(4), IL4(1), IL5(2), INPP5D(12), KRAS(169), LAT(4), LCP2(10), LYN(6), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK8(2), MAPK9(8), MS4A2(7), NRAS(4), PDK1(6), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PRKCA(10), PRKCD(7), PRKCE(5), RAC2(2), RAF1(6), SOS1(17), SOS2(13), SYK(5), TNF(2), VAV1(8), VAV2(8), VAV3(32)	57520397	678	359	501	144	61	336	145	41	93	2	9.88e-07	1.000	1.000
168	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(7), AKT3(8), BAD(1), CASP9(6), CDC42(2), HRAS(2), KDR(56), KRAS(169), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPKAPK2(2), MAPKAPK3(3), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NOS3(12), NRAS(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PPP3CA(14), PPP3CB(4), PPP3CC(3), PPP3R1(5), PPP3R2(6), PRKCA(10), PRKCG(20), PTGS2(12), PTK2(6), PXN(2), RAC2(2), RAF1(6), SH2D2A(10), SHC2(5), SPHK2(4), SRC(2), VEGFA(1)	57134632	661	358	480	156	65	342	135	55	63	1	2.04e-05	1.000	1.000
169	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(8), ACTN2(43), ACTN4(6), ARHGAP5(17), BCAR1(3), CD99(3), CDC42(2), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN7(1), CLDN8(6), CLDN9(2), CTNNA1(10), CTNNA2(66), CTNNA3(22), CTNNB1(20), CTNND1(10), CXCL12(8), CXCR4(6), CYBA(1), CYBB(11), ESAM(2), EZR(3), F11R(3), GNAI1(10), GNAI2(1), GNAI3(2), ICAM1(2), ITGA4(39), ITGAL(26), ITGAM(24), ITGB1(7), ITGB2(8), ITK(16), JAM2(9), JAM3(4), MAPK12(2), MAPK13(1), MAPK14(6), MLLT4(12), MMP2(24), MMP9(10), MSN(8), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLPF(3), NCF1(3), NCF2(8), NCF4(4), NOX1(8), NOX3(21), OCLN(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), PTK2B(14), PTPN11(9), PXN(2), RAC2(2), RAP1A(1), RAP1B(2), RAPGEF3(7), RAPGEF4(13), RHOA(4), RHOH(6), ROCK1(19), ROCK2(9), SIPA1(2), THY1(6), TXK(7), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCAM1(28), VCL(8)	99432479	955	357	932	276	113	413	199	83	145	2	0.0384	1.000	1.000
170	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(10), ACTN1(8), ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(8), ANGPTL2(5), ARHGEF6(21), ARHGEF7(6), BCAR1(3), BRAF(44), CAV1(1), CDC42(2), CDKN2A(23), CRK(1), CSE1L(7), DOCK1(15), EPHB2(11), FYN(9), GRB2(7), GRB7(9), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA3(10), ITGA4(39), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), MAP2K4(8), MAP2K7(7), MAP3K11(8), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MRAS(1), MYLK(26), MYLK2(9), P4HB(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CA(30), PIK3CB(8), PKLR(16), PLCG1(7), PLCG2(18), PTEN(11), PTK2(6), RAF1(6), RALA(5), RHO(7), ROCK1(19), ROCK2(9), SHC1(6), SOS1(17), SOS2(13), SRC(2), TLN1(15), TLN2(31), VASP(2), WAS(8), ZYX(6)	97934119	834	354	783	227	101	322	172	69	168	2	0.0321	1.000	1.000
171	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(22), AMY2A(6), AMY2B(11), ASCC3(24), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(4), DDX56(3), DHX58(4), ENPP1(14), ENPP3(19), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), G6PC(7), G6PC2(8), GAA(12), GANC(3), GBA(7), GBA3(1), GBE1(8), GCK(7), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), IFIH1(10), LYZL1(5), MGAM(60), MOV10L1(11), NUDT5(2), NUDT8(2), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(28), SI(117), SKIV2L2(15), SMARCA2(22), SMARCA5(5), TREH(1), UGDH(6), UGP2(4), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), UXS1(6)	99524772	892	345	884	244	94	377	194	84	143	0	0.0675	1.000	1.000
172	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(6), ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG6(1), ALG8(3), ALG9(8), B3GNT1(3), B3GNT2(4), B3GNT6(5), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT5(6), C1GALT1(6), C1GALT1C1(4), CHPF(10), CHST1(17), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST2(14), CHST3(1), CHST4(3), CHST6(7), CHST7(2), CHSY1(5), DAD1(2), DDOST(1), DPAGT1(5), EXT1(8), EXT2(12), EXTL1(8), EXTL2(3), EXTL3(13), FUT11(5), FUT8(7), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GANAB(9), GCNT1(8), GCNT3(2), GCNT4(9), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(4), HS6ST3(12), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(8), MGAT5(13), MGAT5B(22), NDST1(6), NDST2(6), NDST3(16), NDST4(36), OGT(19), RPN1(3), RPN2(4), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST6GAL1(4), ST6GALNAC1(8), STT3B(4), UST(5), WBSCR17(33), XYLT1(44), XYLT2(3)	88486212	809	345	800	269	127	298	187	85	110	2	0.616	1.000	1.000
173	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(19), ABCA10(34), ABCA12(39), ABCA13(86), ABCA2(21), ABCA3(11), ABCA4(19), ABCA5(23), ABCA6(27), ABCA7(18), ABCA8(25), ABCA9(26), ABCB1(45), ABCB10(11), ABCB11(28), ABCB4(19), ABCB5(62), ABCB6(4), ABCB7(12), ABCB8(11), ABCB9(7), ABCC1(14), ABCC10(11), ABCC11(38), ABCC12(24), ABCC2(11), ABCC3(13), ABCC4(21), ABCC5(14), ABCC6(9), ABCC8(25), ABCC9(30), ABCD1(2), ABCD2(14), ABCD3(2), ABCD4(5), ABCG1(8), ABCG2(15), ABCG4(16), ABCG5(20), ABCG8(19), CFTR(11), TAP1(1), TAP2(9)	94274026	879	341	873	260	86	338	206	89	156	4	0.0604	1.000	1.000
174	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(13), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADK(2), ADSL(2), ADSS(6), AK2(4), AK5(14), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), ATP1B1(6), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5F1(3), ATP5G3(2), ATP5J2(2), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(12), GMPS(9), GUCY1A2(29), GUCY1A3(16), GUCY1B3(11), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(3), HPRT1(1), IMPDH1(7), IMPDH2(4), ITPA(1), NPR1(16), NPR2(6), NT5E(5), NT5M(3), NUDT2(3), PAICS(1), PAPSS1(5), PAPSS2(10), PDE1A(17), PDE4A(8), PDE4B(17), PDE4C(4), PDE4D(8), PDE5A(8), PDE6B(15), PDE6C(12), PDE6G(3), PDE7B(6), PDE8A(3), PDE9A(10), PFAS(9), PKLR(16), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), PPAT(1), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RRM1(6), RRM2(6)	102556225	864	336	859	281	104	322	195	91	150	2	0.558	1.000	1.000
175	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(3), CALM2(1), CALML3(3), CALML6(1), CDIPT(1), CDS1(3), CDS2(4), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(38), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(2), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5D(12), INPP5E(2), INPPL1(11), ITPK1(1), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), OCRL(13), PI4KA(17), PI4KB(10), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3C3(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PLCD1(5), PLCD3(2), PLCD4(7), PLCE1(29), PLCG1(7), PLCG2(18), PLCZ1(10), PRKCA(10), PRKCG(20), PTEN(11), PTPMT1(2), SYNJ1(14), SYNJ2(10)	99499360	832	335	815	233	104	318	188	73	146	3	0.0527	1.000	1.000
176	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(24), BDKRB1(1), BDKRB2(3), C1QA(7), C1QB(11), C1QC(5), C1R(4), C1S(4), C2(5), C3(13), C3AR1(11), C4BPA(6), C4BPB(1), C5(6), C5AR1(7), C6(29), C7(39), C8A(18), C8B(20), C9(20), CD46(4), CD55(3), CFB(10), CFH(46), CFI(6), CPB2(6), CR1(34), CR2(20), F10(5), F11(13), F12(4), F13A1(29), F13B(28), F2(9), F2R(10), F3(3), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), KNG1(9), MASP1(24), MASP2(8), MBL2(13), PLAT(12), PLAU(3), PLAUR(4), PLG(32), PROC(4), PROS1(30), SERPINA1(4), SERPINA5(18), SERPINC1(5), SERPIND1(3), SERPINE1(14), SERPINF2(2), SERPING1(7), TFPI(5), THBD(4), VWF(33)	72761103	872	334	861	248	74	414	159	76	147	2	0.153	1.000	1.000
177	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(8), BCAR1(3), CAPN1(2), CAPN10(8), CAPN11(13), CAPN2(5), CAPN3(8), CAPN5(12), CAPN6(25), CAPN7(7), CAPN9(5), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(2), CRK(1), CSK(2), DOCK1(15), FYN(9), GIT2(5), GRB2(7), ILK(1), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(10), ITGA4(39), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(7), ITGB2(8), ITGB3(17), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAPK10(6), MAPK12(2), MAPK4(9), MAPK6(4), MAPK7(7), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PDPK1(3), PIK3R2(7), PTK2(6), PXN(2), RAC2(2), RAP1B(2), RAPGEF1(7), RHO(7), ROCK1(19), ROCK2(9), SDCCAG8(12), SEPP1(5), SHC1(6), SHC3(8), SORBS1(12), SOS1(17), SRC(2), TLN1(15), TNS1(23), VASP(2), VAV2(8), VAV3(32), VCL(8), ZYX(6)	107108167	932	333	921	262	92	390	193	77	176	4	0.0331	1.000	1.000
178	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(10), CD14(1), CD19(5), CD1A(23), CD1B(17), CD1C(15), CD1D(10), CD1E(30), CD2(6), CD22(16), CD33(13), CD34(13), CD36(4), CD37(2), CD38(4), CD3D(2), CD3E(2), CD4(8), CD44(7), CD5(7), CD55(3), CD8A(4), CD8B(5), CD9(3), CR1(34), CR2(20), CSF1(1), CSF1R(18), CSF2RA(11), CSF3R(7), DNTT(6), EPO(6), EPOR(2), FCER2(2), FCGR1A(5), FLT3(24), FLT3LG(2), GP5(8), GYPA(5), HLA-DRA(3), HLA-DRB1(5), IL11RA(1), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL2RA(6), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(10), IL6(2), IL6R(8), IL7(2), IL7R(21), IL9R(20), ITGA1(14), ITGA2(25), ITGA2B(12), ITGA3(10), ITGA4(39), ITGA5(11), ITGA6(12), ITGAM(24), ITGB3(17), KIT(12), KITLG(6), MME(20), MS4A1(11), TFRC(7), THPO(9), TNF(2), TPO(35)	65727396	742	316	729	225	75	308	136	72	151	0	0.354	1.000	1.000
179	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(28), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(4), ACSL6(16), ADIPOQ(6), ADIPOR1(7), ADIPOR2(3), AKT1(3), AKT2(7), AKT3(8), CAMKK1(5), CAMKK2(3), CD36(4), CHUK(7), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), G6PC(7), G6PC2(8), IKBKB(9), IRS1(20), IRS4(34), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), MAPK10(6), MAPK8(2), MAPK9(8), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NPY(4), PCK1(22), PCK2(4), POMC(4), PPARA(4), PPARGC1A(24), PRKAA1(7), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5), PRKAG3(9), PRKCQ(12), PTPN11(9), RELA(3), RXRA(1), RXRB(3), RXRG(18), SLC2A1(1), SLC2A4(4), STAT3(11), STK11(87), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5), TYK2(5)	65718655	598	314	577	182	67	206	106	63	156	0	0.419	1.000	1.000
180	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(7), AKT3(8), CASP8(6), CCL4(2), CD14(1), CD40(3), CD80(3), CD86(11), CHUK(7), CXCL10(1), CXCL11(1), CXCL9(4), FADD(2), FOS(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IKBKB(9), IKBKE(9), IL12A(2), IL12B(3), IL1B(1), IL6(2), IRAK1(6), IRAK4(4), IRF3(1), IRF5(1), IRF7(3), JUN(3), LBP(8), LY96(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K7(10), MAP3K8(5), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK8(2), MAPK9(8), MYD88(3), NFKB1(6), NFKB2(5), NFKBIA(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), RELA(3), RIPK1(11), SPP1(5), STAT1(7), TBK1(4), TICAM1(3), TLR1(9), TLR2(10), TLR3(4), TLR4(64), TLR5(8), TLR6(11), TLR7(17), TLR8(16), TLR9(13), TNF(2), TOLLIP(3), TRAF3(4), TRAF6(6)	71758645	613	309	599	186	55	244	135	73	106	0	0.364	1.000	1.000
181	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(7), ACVR1B(11), ACVR1C(11), ACVR2A(5), ACVR2B(4), ACVRL1(12), AMHR2(6), BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(14), BMP8A(2), BMP8B(1), BMPR1A(4), BMPR1B(7), BMPR2(10), CHRD(13), COMP(4), CREBBP(30), CUL1(14), DCN(5), E2F4(5), E2F5(1), EP300(11), FST(5), GDF5(12), GDF6(10), GDF7(5), ID1(1), ID2(4), ID3(3), IFNG(7), INHBA(31), INHBB(4), INHBC(4), INHBE(5), LEFTY1(9), LEFTY2(4), LTBP1(61), MAPK1(2), MAPK3(3), MYC(4), NODAL(4), NOG(1), PITX2(8), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(13), PPP2R2C(6), RBL1(7), RBL2(5), RHOA(4), ROCK1(19), ROCK2(9), RPS6KB1(3), RPS6KB2(3), SKP1(4), SMAD1(7), SMAD2(7), SMAD3(7), SMAD4(23), SMAD5(1), SMAD6(2), SMAD9(4), SMURF1(8), SMURF2(4), SP1(6), TFDP1(11), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNF(2), ZFYVE16(7), ZFYVE9(14)	79353108	671	305	666	176	112	241	142	66	109	1	0.0158	1.000	1.000
182	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(7), AKT3(8), ASAH1(3), BRAF(44), DAG1(3), DRD2(26), EGFR(87), EPHB2(11), GRB2(7), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PI3(1), PIK3CB(8), PITX2(8), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), RAF1(6), RGS20(8), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT3(11)	46979625	532	303	452	119	51	190	114	65	110	2	0.00322	1.000	1.000
183	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(10), BAD(1), BCL2(5), CABIN1(10), CALM1(3), CALM2(1), CAMK2B(16), CAMK4(16), CD3E(2), CD69(2), CDKN1A(2), CNR1(15), CREBBP(30), CSNK2A1(5), CTLA4(3), EGR2(4), EGR3(1), EP300(11), FCER1A(9), FCGR3A(7), FOS(3), FOSL1(4), GATA3(12), GATA4(7), GSK3A(1), GSK3B(4), HRAS(2), ICOS(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL13(2), IL1B(1), IL2(7), IL2RA(6), IL3(4), IL4(1), IL6(2), ITK(16), JUNB(1), KPNA5(4), MAP2K7(7), MAPK14(6), MAPK8(2), MAPK9(8), MEF2A(2), MEF2B(2), MEF2D(4), MYF5(12), NCK2(6), NFAT5(13), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NFKB2(5), NFKBIB(3), NFKBIE(2), NPPB(3), NUP214(26), OPRD1(2), P2RX7(6), PAK1(9), PIN1(1), PPP3CB(4), PPP3CC(3), PPP3R1(5), PTPRC(41), RELA(3), RPL13A(2), SFN(1), SLA(9), SP1(6), SP3(6), TGFB1(3), TNF(2), TRAF2(5), TRPV6(25), VAV1(8), VAV2(8), VAV3(32), XPO5(6)	72801598	594	300	589	181	68	229	124	49	122	2	0.330	1.000	1.000
184	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(4), ALG6(1), CCKBR(24), CCR2(6), CCR3(4), CCR5(4), CELSR1(17), CELSR2(22), CELSR3(36), CHRM2(39), CHRM3(27), CIDEB(2), CXCR3(3), DRD4(2), EDNRA(3), EMR2(13), EMR3(10), F2R(10), FSHR(37), GHRHR(7), GNRHR(7), GPR116(11), GPR132(6), GPR133(18), GPR135(4), GPR143(2), GPR17(8), GPR18(4), GPR55(9), GPR61(8), GPR84(4), GRM1(48), GRPR(7), HRH4(5), LGR6(22), LPHN2(48), LPHN3(78), NTSR1(10), OR2M4(33), P2RY13(1), PTGFR(12), SMO(17), SSTR2(4), TAAR5(11), TSHR(22), VN1R1(2)	52700176	672	296	666	200	98	273	138	66	95	2	0.00766	1.000	1.000
185	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(3), AKT2(7), AKT3(8), BAD(1), BCL2L1(3), CDC42(2), CDK2(1), CDKN1B(5), CDKN2A(23), CREB1(2), CREB3(1), CREB5(18), EBP(3), ERBB4(52), F2RL2(12), GAB1(7), GADD45A(2), GRB2(7), GSK3A(1), GSK3B(4), IFI27(1), IGF1(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), MET(22), MYC(4), NOLC1(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARD3(15), PARD6A(1), PDK1(6), PIK3CA(30), PIK3CD(4), PPP1R13B(7), PREX1(41), PTEN(11), PTK2(6), PTPN1(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SLC2A4(4), SOS1(17), SOS2(13), TSC1(10), TSC2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	61212291	565	296	541	128	72	234	109	40	110	0	0.000346	1.000	1.000
186	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(9), AKT1(3), BDKRB2(3), CALM1(3), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(17), FLT1(31), FLT4(20), KDR(56), NOS3(12), PDE2A(11), PDE3A(30), PDE3B(16), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKG1(20), PRKG2(15), RYR2(360), SLC7A1(5), SYT1(6), TNNI1(3)	32393146	653	289	633	183	62	298	128	63	93	9	0.0313	1.000	1.000
187	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(33), ASH2L(2), CARM1(4), CTCFL(21), DOT1L(14), EED(8), EHMT1(15), EHMT2(9), EZH1(4), EZH2(11), FBXO11(5), HCFC1(24), HSF4(1), JMJD4(3), JMJD6(3), KDM6A(12), MEN1(6), NSD1(23), OGT(19), PAXIP1(7), PPP1CA(3), PPP1CB(4), PPP1CC(1), PRDM2(21), PRDM7(6), PRDM9(82), PRMT1(1), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), RBBP5(3), SATB1(10), SETD1A(18), SETD2(39), SETD7(2), SETD8(1), SETDB1(11), SETDB2(13), SETMAR(5), SMYD3(10), STK38(3), SUV39H1(2), SUV39H2(4), SUV420H1(16), WHSC1(12), WHSC1L1(9)	95093196	532	279	526	150	56	207	125	45	93	6	0.465	1.000	1.000
188	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(7), AKT3(8), BRAF(44), CAB39(2), DDIT4(4), EIF4B(7), FIGF(4), HIF1A(2), IGF1(4), MAPK1(2), MAPK3(3), PDPK1(3), PGF(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PRKAA1(7), PRKAA2(8), RHEB(4), RICTOR(25), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(19), RPS6KB1(3), RPS6KB2(3), STK11(87), TSC1(10), TSC2(13), ULK1(8), ULK2(9), ULK3(2), VEGFA(1), VEGFB(3), VEGFC(21)	41941776	448	279	394	87	44	166	86	41	109	2	0.000144	1.000	1.000
189	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(10), BRAF(44), CHUK(7), CREB1(2), DAXX(8), ELK1(3), FOS(3), GRB2(7), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(8), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(5), MAP3K9(17), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(9), MAP4K5(2), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK4(9), MAPK6(4), MAPK7(7), MAPK8(2), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MKNK2(2), MYC(4), NFKB1(6), NFKBIA(4), PAK1(9), PAK2(3), RAF1(6), RELA(3), RIPK1(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KB1(3), RPS6KB2(3), SHC1(6), SP1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5)	75906247	533	279	504	138	58	189	112	47	126	1	0.0656	1.000	1.000
190	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(2), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5E(2), INPPL1(11), IPMK(11), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(7), MINPP1(3), MIOX(2), OCRL(13), PI4KA(17), PI4KB(10), PIK3C3(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PLCD1(5), PLCD3(2), PLCD4(7), PLCE1(29), PLCG1(7), PLCG2(18), PLCZ1(10), PTEN(11), PTPMT1(2), SYNJ1(14), SYNJ2(10)	59264272	489	272	475	139	56	192	118	42	79	2	0.131	1.000	1.000
191	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(9), ADAM17(8), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), CASP3(5), CDC42(2), CHUK(7), CSK(2), CXCL1(1), EGFR(87), F11R(3), GIT1(3), IGSF5(6), IKBKB(9), JAM2(9), JAM3(4), JUN(3), LYN(6), MAP2K4(8), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK8(2), MAPK9(8), MET(22), NFKB1(6), NFKB2(5), NFKBIA(4), NOD1(8), PAK1(9), PLCG1(7), PLCG2(18), PTPN11(9), PTPRZ1(72), RELA(3), SRC(2), TCIRG1(2), TJP1(15)	56419102	454	269	398	125	44	137	78	67	127	1	0.358	1.000	1.000
192	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(33), AR(10), ASAH1(3), BRAF(44), CAMP(4), CCL13(3), CCL15(5), CCL16(4), DAG1(3), EGFR(87), GNA11(4), GNA15(1), GNAI1(10), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), MAPK10(6), MAPK14(6), PHKA2(14), PIK3CA(30), PIK3CD(4), PIK3R1(4), PITX2(8), PTX3(3), RAF1(6), SRC(2)	42843438	442	269	354	81	39	150	97	50	105	1	0.000143	1.000	1.000
193	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(9), AGTR2(6), ATP8A1(8), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CX3CR1(12), CXCR3(3), CXCR4(6), CXCR6(2), EDNRA(3), EDNRB(17), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(6), GNB2L1(3), GNRHR(7), GRPR(7), LHCGR(14), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), NMBR(8), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(16), OXTR(4), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), TAC4(1), TACR1(4), TACR2(2), TACR3(15), TRHR(14), TSHR(22)	42039386	572	268	564	217	90	237	124	55	65	1	0.383	1.000	1.000
194	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(8), ANGPTL2(5), ARHGAP1(5), ARHGAP4(14), ARHGEF11(25), BTK(25), CDC42(2), CFL2(3), GDI1(6), GDI2(1), INPPL1(11), ITPR1(20), ITPR2(40), ITPR3(21), LIMK1(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3CG(33), PIK3R1(4), PITX2(8), PPP1R13B(7), PTEN(11), RACGAP1(7), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), SAG(5), WASF1(10), WASL(7)	56336808	482	263	465	126	71	181	96	38	96	0	0.0192	1.000	1.000
195	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(7), AKT3(8), BAD(1), BCL2(5), BCR(11), BLNK(2), BTK(25), CD19(5), CD22(16), CD81(1), CR2(20), CSK(2), DAG1(3), FLOT1(1), FLOT2(4), GRB2(7), GSK3A(1), GSK3B(4), INPP5D(12), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(11), NFATC2(15), NR0B2(3), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PTPRC(41), RAF1(6), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8)	59335258	457	261	438	136	56	169	108	34	90	0	0.252	1.000	1.000
196	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(5), CDC40(4), CLK2(10), CLK3(2), CLK4(4), COL2A1(24), CPSF1(14), CPSF2(8), CPSF3(6), CSTF1(7), CSTF2(3), CSTF2T(7), CSTF3(7), DDIT3(2), DDX1(9), DDX20(5), DHX15(7), DHX16(7), DHX38(9), DHX8(14), DHX9(12), DICER1(16), DNAJC8(4), FUS(5), GIPC1(6), LSM2(1), LSM7(2), METTL3(3), NCBP1(3), NCBP2(3), NONO(6), NXF1(11), PABPN1(5), PAPOLA(11), POLR2A(11), PPM1G(6), PRPF18(3), PRPF3(5), PRPF4(3), PRPF4B(11), PRPF8(10), PSKH1(3), PTBP1(4), PTBP2(9), RBM17(4), RBM5(6), RNGTT(10), RNMT(9), RNPS1(1), SF3A1(10), SF3A2(1), SF3A3(2), SF3B1(15), SF3B2(14), SF3B4(8), SF3B5(3), SFRS6(2), SNRPA(1), SNRPA1(1), SNRPB(3), SNRPB2(1), SNRPD1(2), SNRPD3(4), SNRPE(1), SNRPG(2), SNRPN(15), SNURF(2), SPOP(4), SRPK1(5), SRPK2(6), SRRM1(4), SUPT5H(9), U2AF1(13), U2AF2(6), XRN2(8)	85058513	479	260	463	126	71	167	103	53	85	0	0.178	1.000	1.000
197	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(22), AMY2A(6), AMY2B(11), ENPP1(14), ENPP3(19), G6PC(7), GAA(12), GANAB(9), GBA3(1), GBE1(8), GCK(7), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), MGAM(60), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RNPC3(1), SI(117), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2B15(14), UGT2B4(28), UXS1(6)	45835022	512	254	507	138	59	230	104	43	76	0	0.0510	1.000	1.000
198	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(13), ADCY6(10), ADCY8(48), CACNA1A(32), CACNA1B(41), GNAS(29), GNAT3(6), GNB1(2), GNB3(5), GNG13(5), GNG3(1), GRM4(21), ITPR3(21), KCNB1(28), PDE1A(17), PLCB2(12), PRKACA(3), PRKACB(11), PRKACG(4), PRKX(3), SCNN1A(2), SCNN1B(6), SCNN1G(8), TAS1R1(5), TAS1R2(28), TAS1R3(6), TAS2R1(20), TAS2R10(2), TAS2R13(2), TAS2R14(4), TAS2R16(15), TAS2R3(2), TAS2R38(9), TAS2R39(5), TAS2R4(3), TAS2R40(7), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R5(3), TAS2R50(1), TAS2R60(9), TAS2R7(3), TAS2R9(3), TRPM5(13)	45162780	491	253	483	162	86	195	122	30	58	0	0.104	1.000	1.000
199	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(9), AGT(4), AKT1(3), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK1G(2), CAMK4(16), CREBBP(30), CSNK1A1(2), EDN1(1), ELSPBP1(8), F2(9), FGF2(2), GATA4(7), GSK3B(4), HAND1(5), HAND2(10), HRAS(2), IGF1(4), LIF(3), MAP2K1(10), MAPK1(2), MAPK14(6), MAPK3(3), MAPK8(2), MEF2C(6), MYH2(77), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NKX2-5(8), NPPA(3), PIK3CA(30), PIK3R1(4), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAF1(6), RPS6KB1(3), SYT1(6)	40746036	394	251	376	95	58	161	84	30	60	1	0.00563	1.000	1.000
200	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(4), AKR1D1(12), ARSD(6), ARSE(5), CARM1(4), CYP11B1(28), CYP11B2(24), CYP19A1(4), HSD11B1(9), HSD17B1(2), HSD17B12(4), HSD17B2(6), HSD17B3(3), HSD17B7(3), HSD3B1(6), HSD3B2(15), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), SULT2B1(2), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), WBSCR22(3)	40649497	444	248	438	126	40	199	107	41	56	1	0.118	1.000	1.000
201	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(26), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), ITPA(1), NME6(3), NME7(4), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5C3(1), NT5E(5), NT5M(3), NUDT2(3), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PRIM1(3), PRIM2(14), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), TK1(2), TK2(1), TXNRD1(7), TXNRD2(2), TYMS(3), UCK2(10), UMPS(5), UPB1(2), UPP1(6), UPP2(6), UPRT(5), ZNRD1(1)	64981879	434	247	433	122	51	172	104	39	65	3	0.187	1.000	1.000
202	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(14), BMP8A(2), BMP8B(1), BTRC(12), CSNK1A1(2), CSNK1A1L(14), CSNK1D(7), CSNK1E(6), CSNK1G1(4), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(2), GLI1(17), GLI2(28), GLI3(39), GSK3B(4), HHIP(4), IHH(3), LRP2(88), PRKACA(3), PRKACB(11), PRKACG(4), PRKX(3), PTCH1(16), PTCH2(8), RAB23(1), SHH(2), SMO(17), STK36(13), SUFU(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(11), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6), ZIC2(3)	48461340	483	247	476	137	98	194	104	33	54	0	0.0357	1.000	1.000
203	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AGK(6), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(11), AGPAT6(5), AKR1A1(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CEL(8), DAK(4), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(38), DGKQ(1), DGKZ(5), GK(7), GK2(10), GLA(9), GLB1(3), GPAM(6), LCT(50), LIPA(2), LIPC(9), LIPF(9), LIPG(11), LPL(8), MGLL(2), PNLIP(19), PNLIPRP1(14), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1)	46900800	449	240	440	121	53	189	95	38	74	0	0.0337	1.000	1.000
204	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1C1(4), AKR1C2(2), AKR1C3(5), AKR1C4(4), ALDH1A3(4), ALDH3A1(5), ALDH3B1(3), ALDH3B2(4), CYP1A1(9), CYP1A2(3), CYP1B1(5), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(3), CYP2C9(8), CYP2E1(7), CYP2F1(3), CYP2S1(3), CYP3A4(4), CYP3A43(6), CYP3A5(6), CYP3A7(7), DHDH(3), EPHX1(7), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(6), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), MGST1(1), MGST2(2), MGST3(3), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14)	46469574	451	238	446	126	38	209	96	35	73	0	0.0869	1.000	1.000
205	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(7), AKT3(8), BCR(11), BTK(25), CD19(5), CDKN2A(23), DAPP1(3), FLOT1(1), FLOT2(4), GAB1(7), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), NR0B2(3), PDK1(6), PIK3CA(30), PITX2(8), PLCG2(18), PPP1R13B(7), PREX1(41), PTEN(11), PTPRC(41), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SAG(5), SYK(5), TEC(12), VAV1(8)	44383020	402	238	386	90	49	153	90	26	84	0	0.00125	1.000	1.000
206	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(10), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(2), CDH1(6), CLDN1(1), CTNNB1(20), CTTN(7), EZR(3), FYN(9), HCLS1(17), ITGB1(7), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB2C(1), TUBB3(3), TUBB6(3), TUBB8(18), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2)	42267861	376	237	366	105	42	157	72	43	62	0	0.0928	1.000	1.000
207	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(10), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(2), CDH1(6), CLDN1(1), CTNNB1(20), CTTN(7), EZR(3), FYN(9), HCLS1(17), ITGB1(7), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB2C(1), TUBB3(3), TUBB6(3), TUBB8(18), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2)	42267861	376	237	366	105	42	157	72	43	62	0	0.0928	1.000	1.000
208	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(4), ACADM(8), ACOX1(6), ACOX2(3), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(4), ACSL6(16), ADIPOQ(6), ANGPTL4(2), APOA1(3), APOA2(1), APOA5(10), APOC3(2), AQP7(7), CD36(4), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP27A1(5), CYP4A11(8), CYP4A22(1), CYP7A1(8), CYP8B1(4), DBI(1), EHHADH(13), FABP2(1), FABP3(4), FABP4(2), FABP5(1), FABP6(3), FABP7(3), FADS2(4), GK(7), GK2(10), HMGCS2(7), ILK(1), LPL(8), ME1(3), MMP1(11), NR1H3(4), OLR1(8), PCK1(22), PCK2(4), PDPK1(3), PLTP(10), PPARA(4), PPARD(6), PPARG(8), RXRA(1), RXRB(3), RXRG(18), SCD(3), SCP2(4), SLC27A1(4), SLC27A2(4), SLC27A4(4), SLC27A5(7), SLC27A6(24), SORBS1(12), UBC(14), UCP1(3)	52667188	415	236	413	123	54	163	80	50	68	0	0.232	1.000	1.000
209	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), F10(5), F11(13), F12(4), F2(9), F2R(10), F5(40), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), PROC(4), PROS1(30), SERPINC1(5), SERPING1(7)	35804097	443	234	440	122	32	230	77	32	71	1	0.437	1.000	1.000
210	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(6), ACTG2(10), ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), CDC42(2), CFL2(3), FLNA(31), FLNC(55), FSCN1(4), FSCN2(1), FSCN3(15), GDI1(6), GDI2(1), LIMK1(3), MYH2(77), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PFN1(1), PFN2(1), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), VASP(2), WASF1(10), WASL(7)	38011947	394	234	386	130	55	162	69	42	66	0	0.371	1.000	1.000
211	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(33), AXIN1(7), CCND1(3), CCND2(4), CCND3(1), CSNK1E(6), CTNNB1(20), DVL1(5), DVL2(7), DVL3(13), FBXW2(4), FOSL1(4), FZD1(6), FZD10(30), FZD2(8), FZD3(2), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LDLR(10), MAPK10(6), MAPK9(8), MYC(4), PAFAH1B1(1), PLAU(3), PPP2R5C(1), PPP2R5E(5), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), RHOA(4), SFRP4(7), TCF7(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4)	47839156	422	231	410	107	87	156	74	30	73	2	0.00447	1.000	1.000
212	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(5), CHUK(7), DAXX(8), EGF(13), EGFR(87), ETS1(8), ETS2(6), FOS(3), HOXA7(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(4), PPP2CA(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), RAF1(6), RELA(3), RIPK1(11), SP1(6), TNF(2), TNFRSF1B(2), TRAF2(5)	39438567	341	230	289	94	32	97	61	58	91	2	0.447	1.000	1.000
213	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(6), APOA1(3), APOA2(1), CD36(4), CITED2(3), CPT1B(6), CREBBP(30), DUSP1(1), EHHADH(13), EP300(11), HSD17B4(8), JUN(3), LPL(8), MAPK1(2), MAPK3(3), ME1(3), MRPL11(2), MYC(4), NCOA1(18), NCOR1(24), NCOR2(30), NFKBIA(4), NR0B2(3), NR1H3(4), NR2F1(7), NRIP1(13), PDGFA(5), PIK3CA(30), PIK3R1(4), PPARA(4), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PTGS2(12), RB1(33), RELA(3), RXRA(1), SP1(6), STAT5A(3), STAT5B(8), TNF(2)	50606647	361	225	347	95	49	123	71	34	83	1	0.102	1.000	1.000
214	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(8), APH1A(3), CREBBP(30), CTBP1(3), CTBP2(6), DLL1(5), DLL3(6), DLL4(2), DTX1(10), DTX2(6), DTX3(7), DTX3L(3), DTX4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), HDAC1(4), HDAC2(8), HES1(2), JAG1(16), JAG2(7), LFNG(3), MAML1(9), MAML2(10), MAML3(9), MFNG(1), NCOR2(30), NCSTN(13), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), NUMB(3), NUMBL(3), PSEN1(6), PSEN2(10), PSENEN(2), PTCRA(8), RBPJ(3), RBPJL(5), RFNG(1), SNW1(3)	54216501	399	224	398	117	65	149	82	38	64	1	0.151	1.000	1.000
215	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(4), ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(3), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), ALDOA(6), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), G6PC2(8), GALM(2), GAPDH(5), GAPDHS(10), GCK(7), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKL(9), PFKM(7), PFKP(6), PGAM1(1), PGAM2(1), PGAM4(6), PGK1(4), PGK2(27), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	46692040	403	223	398	121	59	170	74	38	62	0	0.159	1.000	1.000
216	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MIOX(2), OCRL(13), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CA(30), PIK3CB(8), PIK3CG(33), PLCB1(56), PLCB2(12), PLCB3(9), PLCB4(36), PLCD1(5), PLCG1(7), PLCG2(18)	35920520	349	220	336	89	44	140	77	31	56	1	0.0447	1.000	1.000
217	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(6), APAF1(10), ARHGDIB(2), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), GSN(4), LMNA(2), LMNB1(5), LMNB2(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK8(2), MDM2(5), NFKB1(6), NFKBIA(4), NUMA1(18), PAK2(3), PRKCD(7), PRKDC(50), PSEN1(6), PSEN2(10), PTK2(6), RASA1(11), RB1(33), RELA(3), RIPK1(11), SPTAN1(21), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5)	55298179	351	218	349	96	27	104	77	41	102	0	0.476	1.000	1.000
218	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(9), CRK(1), CRKL(4), DOCK1(15), ELK1(3), FOS(3), GAB1(7), GRB2(7), HGF(54), HRAS(2), ITGA1(14), ITGB1(7), JUN(3), MAP2K1(10), MAP2K2(1), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(2), MET(22), PAK1(9), PIK3CA(30), PIK3R1(4), PTEN(11), PTK2(6), PTK2B(14), PTPN11(9), PXN(2), RAF1(6), RAP1A(1), RAP1B(2), RASA1(11), SOS1(17), SRC(2), STAT3(11)	35495397	316	217	295	92	23	115	68	43	67	0	0.638	1.000	1.000
219	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(33), ASAH1(3), CAMP(4), CAV3(3), DAG1(3), DLG4(7), EPHB2(11), GNAI1(10), GNAQ(5), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PITX2(8), PTX3(3), RHO(7), RYR1(111)	36904482	343	217	338	97	60	118	80	25	58	2	0.0931	1.000	1.000
220	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(10), CD28(5), CD3D(2), CSK(2), CTLA4(3), DAG1(3), EPHB2(11), FBXW7(17), GRAP2(13), GRB2(7), ITK(16), ITPKA(2), ITPKB(7), LAT(4), LCK(13), LCP2(10), MAPK1(2), NCK1(5), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLCG1(7), PTPRC(41), RAF1(6), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), SOS1(17), SOS2(13), VAV1(8), ZAP70(9)	44571429	370	217	360	114	51	144	68	27	80	0	0.435	1.000	1.000
221	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(11), AKR1A1(1), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), CEL(8), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), GK(7), GLA(9), GLB1(3), LCT(50), LIPC(9), LIPF(9), LIPG(11), LPL(8), PNLIP(19), PNLIPRP1(14), PPAP2A(2), PPAP2B(3), PPAP2C(1)	38463524	383	215	377	92	47	160	78	32	66	0	0.00337	1.000	1.000
222	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(135), B3GALT4(1), CDR1(15), DGKI(38), FAU(1), IL6ST(3), MRPL19(1), PIGK(3), RPL10(4), RPL11(2), RPL13A(2), RPL14(3), RPL15(1), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL27A(2), RPL28(4), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL37(2), RPL3L(8), RPL4(5), RPL41(1), RPL5(8), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPLP0(2), RPLP1(1), RPLP2(3), RPS10(1), RPS11(1), RPS13(1), RPS14(1), RPS15(2), RPS16(5), RPS18(2), RPS19(1), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(19), RPS6KB1(3), RPS6KB2(3), RPS7(1), RPSA(1), SLC36A2(6), UBA52(1), UBC(14)	41821993	374	215	366	101	38	179	73	30	53	1	0.106	1.000	1.000
223	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(13), F12(4), F13B(28), F2(9), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), LPA(47), PLAT(12), PLAU(3), PLG(32), SERPINB2(14), SERPINE1(14), SERPINF2(2), VWF(33)	28374054	384	212	378	105	24	174	81	38	66	1	0.195	1.000	1.000
224	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(11), AGPAT6(5), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CHPT1(3), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(38), DGKQ(1), DGKZ(5), ESCO1(10), ESCO2(4), ETNK1(5), ETNK2(1), GNPAT(5), GPAM(6), GPD1(3), GPD1L(4), GPD2(9), LCAT(6), NAT6(1), PCYT1A(2), PCYT1B(5), PEMT(2), PISD(2), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(22), PLD2(7), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1), PTDSS1(10), PTDSS2(3)	52161680	379	212	371	116	44	137	93	36	68	1	0.550	1.000	1.000
225	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(3), AKT2(7), AKT3(8), BRD4(7), CBL(10), CDC42(2), CDKN2A(23), F2RL2(12), FLOT1(1), FLOT2(4), GRB2(7), GSK3A(1), GSK3B(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), LNPEP(5), MAPK1(2), MAPK3(3), PARD3(15), PARD6A(1), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PTEN(11), PTPN1(3), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SERPINB6(3), SFN(1), SHC1(6), SLC2A4(4), SORBS1(12), SOS1(17), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	47146229	341	212	322	81	41	139	80	24	56	1	0.0200	1.000	1.000
226	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), AFMID(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(3), CYP1B1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), INMT(3), KMO(10), KYNU(17), LCMT1(5), LCMT2(7), LNX1(9), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NFX1(5), OGDH(10), OGDHL(35), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), TDO2(9), TPH1(8), TPH2(16), WARS(6), WARS2(7), WBSCR22(3)	48745420	381	210	374	110	52	129	81	50	69	0	0.173	1.000	1.000
227	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(87), ELK1(3), GNAS(29), GNB1(2), GNGT1(6), GRB2(7), HRAS(2), IGF1R(8), ITGB1(7), KLK2(11), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MYC(4), NGFR(5), PDGFRA(41), PPP2CA(1), PTPRR(16), RAF1(6), RPS6KA1(6), RPS6KA5(10), SHC1(6), SOS1(17), SRC(2), STAT3(11)	26484085	309	209	252	63	35	104	51	52	66	1	0.00984	1.000	1.000
228	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(3), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), HSD3B7(7), NSD1(23), OGDH(10), OGDHL(35), PIPOX(2), PLOD1(5), PLOD2(13), PLOD3(10), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SETD1A(18), SETD7(2), SETDB1(11), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(2), SUV39H1(2), SUV39H2(4), TMLHE(9)	46424015	338	209	334	93	50	133	73	34	46	2	0.0814	1.000	1.000
229	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(3), ATF1(1), BRAF(44), CAMP(4), CREB1(2), CREB3(1), CREB5(18), CREBBP(30), CRKL(4), DAG1(3), EGR1(6), EGR2(4), EGR3(1), EGR4(3), ELK1(3), FRS2(10), GNAQ(5), JUN(3), MAP1B(29), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), NTRK1(14), OPN1LW(9), PIK3C2G(19), PIK3CA(30), PIK3CD(4), PIK3R1(4), PTPN11(9), RPS6KA3(6), SHC1(6), SRC(2), TH(7)	40873459	336	208	300	84	50	137	74	20	53	2	0.00937	1.000	1.000
230	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(3), CALM2(1), CD3D(2), CD3E(2), ELK1(3), FOS(3), FYN(9), GRB2(7), HRAS(2), JUN(3), LAT(4), LCK(13), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NFKB1(6), NFKBIA(4), PIK3CA(30), PIK3R1(4), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKCA(10), PTPN7(1), RAF1(6), RASA1(11), RELA(3), SHC1(6), SOS1(17), SYT1(6), VAV1(8), ZAP70(9)	38495246	284	206	266	78	41	109	52	25	57	0	0.172	1.000	1.000
231	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), EGF(13), EGFR(87), ELK1(3), FOS(3), GRB2(7), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3)	30286601	277	204	213	49	24	75	45	55	78	0	0.00777	1.000	1.000
232	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(17), CALCR(27), CALCRL(18), CD97(12), CRHR1(9), ELTD1(39), EMR1(24), EMR2(13), GHRHR(7), GIPR(3), GLP1R(11), GLP2R(17), GPR64(14), LPHN1(7), LPHN2(48), LPHN3(78), SCTR(5), VIPR1(2), VIPR2(3)	21308194	354	203	351	99	34	144	68	44	63	1	0.0786	1.000	1.000
233	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), HRH1(5), HRH2(17), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(11), HTR4(8), HTR5A(21), HTR6(10), HTR7(11)	20500751	374	203	369	122	56	169	70	31	46	2	0.0170	1.000	1.000
234	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(2), ALAS2(6), BLVRA(3), BLVRB(2), COX10(4), CP(11), CPOX(4), EARS2(5), EPRS(27), FECH(4), FTH1(2), FTMT(11), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), MMAB(3), PPOX(7), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), UROS(2)	34202749	323	201	321	97	21	153	78	25	46	0	0.470	1.000	1.000
235	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(25), CALM1(3), CALM2(1), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(7), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), PAK2(3), PIK3CA(30), PIK3R1(4), PLA2G4A(21), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8)	34558555	290	199	272	64	34	111	67	23	55	0	0.00954	1.000	1.000
236	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(6), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(7), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(6), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	39312877	338	199	334	93	49	142	63	31	53	0	0.0455	1.000	1.000
237	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(6), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(7), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(6), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	39312877	338	199	334	93	49	142	63	31	53	0	0.0455	1.000	1.000
238	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), ASCC3(24), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(4), DDX56(3), DHFR(2), DHX58(4), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), FPGS(3), GCH1(3), GGH(9), IFIH1(10), MOV10L1(11), NUDT5(2), NUDT8(2), PTS(1), QDPR(7), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(28), SKIV2L2(15), SMARCA2(22), SMARCA5(5), SPR(3)	50269127	316	199	314	95	33	102	82	35	64	0	0.508	1.000	1.000
239	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(9), CALR(2), CANX(5), CD4(8), CD8A(4), CD8B(5), CIITA(5), CREB1(2), CTSB(2), CTSS(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), HSP90AA1(9), HSP90AB1(9), HSPA5(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), KIR2DL1(13), KIR2DL3(8), KIR2DL4(4), KIR3DL1(17), KIR3DL2(5), KIR3DL3(2), KLRC1(5), KLRC2(4), KLRC3(3), KLRC4(1), KLRD1(2), LGMN(4), LTA(3), NFYA(1), NFYB(1), NFYC(6), PDIA3(4), PSME1(2), PSME2(3), RFX5(9), RFXANK(1), TAP1(1), TAP2(9), TAPBP(5)	37467191	291	198	282	88	23	115	61	40	52	0	0.456	1.000	1.000
240	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(12), ADC(2), ALDH4A1(6), ALDH5A1(2), CAD(26), CPS1(71), EARS2(5), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GFPT2(10), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), GMPS(9), GNPNAT1(1), GOT1(3), GOT2(6), GPT2(5), GSR(5), GSS(4), NADSYN1(2), NAGK(6), PPAT(1), QARS(7)	31784864	304	195	303	77	28	123	55	35	62	1	0.0593	1.000	1.000
241	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), ELK1(3), FPR1(10), GNA15(1), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(6), MAPK3(3), NCF1(3), NCF2(8), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), NFKB1(6), NFKBIA(4), PAK1(9), PIK3C2G(19), PLCB1(56), PPP3CA(14), PPP3CB(4), PPP3CC(3), RAF1(6), RELA(3), SYT1(6)	30659672	272	194	262	67	32	116	48	22	54	0	0.0343	1.000	1.000
242	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), CARM1(4), COMT(1), DBH(12), DCT(16), DDC(8), ECH1(1), ESCO1(10), ESCO2(4), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NAT6(1), PNMT(1), PNPLA3(4), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), TAT(9), TH(7), TPO(35), TYR(29), TYRP1(5), WBSCR22(3)	47774422	344	194	339	110	57	129	57	38	63	0	0.398	1.000	1.000
243	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(9), ATF2(10), CALM1(3), CALM2(1), EGFR(87), ELK1(3), GNAQ(5), GRB2(7), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PAK1(9), PRKCA(10), PTK2(6), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6)	26949018	257	193	202	49	27	78	33	46	73	0	0.0113	1.000	1.000
244	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(7), AKR1B10(10), B4GALT1(1), B4GALT2(4), G6PC(7), G6PC2(8), GAA(12), GALE(1), GALK1(3), GALK2(3), GALT(5), GANC(3), GCK(7), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), HSD3B7(7), LCT(50), MGAM(60), PFKL(9), PFKM(7), PFKP(6), PGM1(3), PGM3(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2), UGP2(4)	30815039	287	193	285	87	47	121	58	21	40	0	0.148	1.000	1.000
245	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(26), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ITPA(1), NT5E(5), NT5M(3), NUDT2(3), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), RRM1(6), RRM2(6), TK1(2), TK2(1), TXNRD1(7), TYMS(3), UCK2(10), UMPS(5), UNG(5), UPB1(2), UPP1(6)	45844839	319	193	317	96	39	126	73	32	47	2	0.397	1.000	1.000
246	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CAT(3), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(3), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(6), CYP3A7(7), CYP4B1(14), CYP51A1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADHA(3), KMO(10), KYNU(17), MAOA(5), MAOB(3), SDS(4), TDO2(9), TPH1(8), WARS(6), WARS2(7)	44374676	347	192	343	115	43	131	70	44	59	0	0.591	1.000	1.000
247	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(6), ALDOB(8), ALDOC(2), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GAPDHS(10), GCK(7), GOT1(3), GOT2(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6B(3), LDHB(4), LDHC(6), MDH1(3), MDH2(3), PC(9), PCK1(22), PDHA1(5), PDHA2(29), PDHX(4), PFKL(9), PFKM(7), PFKP(6), PGAM1(1), PGAM2(1), PGK1(4), PGK2(27), PKLR(16), TNFAIP1(1), TPI1(9)	34015838	321	191	320	95	53	137	50	34	47	0	0.0858	1.000	1.000
248	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(7), AKT3(8), BAD(1), BCR(11), BLNK(2), BTK(25), CD19(5), CSK(2), DAG1(3), EPHB2(11), GRB2(7), ITPKA(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PI3(1), PIK3CA(30), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), RAF1(6), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8)	42056644	282	191	264	81	29	103	71	27	52	0	0.277	1.000	1.000
249	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH4A1(6), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), GATM(8), GLUD1(4), GOT1(3), GOT2(6), MAOA(5), MAOB(3), NOS1(29), NOS3(12), OAT(3), ODC1(1), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), P4HB(5), PYCR1(1), RARS(6), SMS(3)	35307606	282	190	280	90	37	102	55	38	49	1	0.391	1.000	1.000
250	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(7), ARRB2(4), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CLCA1(14), CLCA2(29), CLCA4(31), CNGA3(15), CNGA4(17), CNGB1(10), GNAL(5), GUCA1A(7), GUCA1B(4), GUCA1C(7), PDC(1), PDE1C(29), PRKACA(3), PRKACB(11), PRKACG(4), PRKG1(20), PRKG2(15), PRKX(3)	24535411	278	190	276	87	28	122	54	22	52	0	0.411	1.000	1.000
251	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(10), EGF(13), EGFR(87), GRB2(7), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), PTPRB(58), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), SRC(2)	20159948	255	190	201	55	21	68	46	48	72	0	0.122	1.000	1.000
252	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(11), AGPS(6), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CLC(3), CPT1B(6), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), ETNK1(5), GNPAT(5), GPD1(3), GPD2(9), LCAT(6), LGALS13(5), PAFAH1B1(1), PAFAH2(3), PCYT1A(2), PCYT1B(5), PEMT(2), PISD(2), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB2(12), PLCG1(7), PLCG2(18), PPAP2A(2), PPAP2B(3), PPAP2C(1)	39734673	311	189	305	99	45	102	77	28	58	1	0.512	1.000	1.000
253	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(33), AXIN1(7), CCND1(3), CD14(1), CTNNB1(20), DVL1(5), FZD1(6), GJA1(11), GNAI1(10), GSK3B(4), IRAK1(6), LBP(8), LEF1(12), LY96(3), MYD88(3), NFKB1(6), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), RELA(3), TLR4(64), TOLLIP(3), WNT1(6)	24506970	255	187	235	55	25	117	44	22	47	0	0.00997	1.000	1.000
254	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACADVL(2), ACAT1(2), ACAT2(2), ACOX1(6), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(4), ACSL6(16), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP4A11(8), CYP4A22(1), ECHS1(4), EHHADH(13), GCDH(7), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8)	39393905	257	186	251	68	36	93	49	32	47	0	0.104	1.000	1.000
255	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(7), AKT3(8), ARHGEF11(25), BCL2(5), CDC42(2), DLG4(7), GNA13(6), LPA(47), MAP2K4(8), MAP3K1(7), MAP3K5(14), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PI3(1), PIK3CB(8), PLD1(22), PLD2(7), PLD3(4), PTK2(6), RDX(2), ROCK1(19), ROCK2(9), SERPINA4(16), SRF(1), TBXA2R(1)	39339807	278	185	274	71	26	116	50	33	53	0	0.104	1.000	1.000
256	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(23), GABBR1(8), GPRC5A(3), GPRC5B(14), GPRC5C(10), GPRC5D(2), GRM1(48), GRM2(7), GRM3(20), GRM4(21), GRM5(42), GRM7(44), GRM8(53)	16886110	295	184	292	87	50	128	68	18	30	1	0.0366	1.000	1.000
257	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(5), ALOX12(8), ALOX12B(8), ALOX15(5), ALOX15B(6), ALOX5(10), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(3), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP2U1(2), CYP4A11(8), CYP4A22(1), CYP4F2(15), CYP4F3(16), DHRS4(1), EPHX2(3), GGT1(1), GPX1(5), GPX3(3), GPX4(1), GPX5(7), GPX6(7), GPX7(4), LTA4H(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(19), PTGS2(12), TBXAS1(11)	31159882	276	184	273	75	42	108	61	25	40	0	0.0530	1.000	1.000
258	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(38), AR(10), ESR1(12), ESR2(6), HNF4A(22), NPM1(5), NR0B1(14), NR1D1(2), NR1D2(1), NR1H2(5), NR1H3(4), NR1I2(4), NR1I3(10), NR2C2(2), NR2E1(10), NR2F1(7), NR2F2(1), NR2F6(1), NR3C1(8), NR4A1(5), NR4A2(18), NR5A1(6), NR5A2(14), PGR(15), PPARA(4), PPARD(6), PPARG(8), RARA(7), RARB(7), RARG(3), ROR1(13), RORA(11), RORC(1), RXRA(1), RXRB(3), RXRG(18), THRA(6), THRB(4), VDR(4)	33642017	316	184	315	110	46	129	68	20	52	1	0.666	1.000	1.000
259	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(7), APC(33), ATF2(10), AXIN1(7), BMP10(11), BMP2(1), BMP4(6), BMP5(6), BMP7(14), BMPR1A(4), BMPR2(10), CHRD(13), CTNNB1(20), DVL1(5), FZD1(6), GATA4(7), GSK3B(4), MAP3K7(10), MEF2C(6), MYL2(8), NKX2-5(8), NOG(1), NPPA(3), NPPB(3), RFC1(13), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), WNT1(6)	29159681	268	183	257	66	36	104	50	27	51	0	0.0941	1.000	1.000
260	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(13), ATP4A(16), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5E(1), ATP5F1(3), ATP5G3(2), ATP5J2(2), ATP5L(3), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6B2(1), COX6C(1), COX7A2(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(7), LHPP(3), NDUFA1(2), NDUFA10(5), NDUFA12(5), NDUFA13(2), NDUFA4(2), NDUFA5(2), NDUFA6(1), NDUFA7(1), NDUFA8(5), NDUFA9(4), NDUFB1(1), NDUFB10(3), NDUFB11(6), NDUFB2(2), NDUFB4(3), NDUFB5(6), NDUFB6(2), NDUFB8(1), NDUFB9(2), NDUFC2(3), NDUFS1(10), NDUFS2(4), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(2), NDUFV1(2), NDUFV2(1), NDUFV3(4), PPA1(2), SDHA(8), SDHB(1), SDHD(3), TCIRG1(2), UQCRB(5), UQCRC1(2), UQCRC2(5), UQCRFS1(3), UQCRH(3), UQCRQ(2)	44713921	285	183	282	104	46	95	58	24	60	2	0.840	1.000	1.000
261	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), DAG1(3), DGKA(7), GCA(3), ITGA9(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAPK1(2), MAPK3(3), NR1I3(10), PAK1(9), PDE3A(30), PDE3B(16), PI3(1), PIK3C2G(19), PIK3CA(30), PIK3CD(4), PIK3R1(4), PSME1(2), RIPK3(5), RPS4X(2), SGCB(4), VASP(2)	39085275	276	182	262	65	29	99	61	28	58	1	0.0354	1.000	1.000
262	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(21), ACACB(28), ACAT1(2), ACAT2(2), ACOT12(11), ACSS1(5), ACSS2(4), ACYP2(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), LDHD(3), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(22), PCK2(4), PDHA1(5), PDHA2(29), PKLR(16)	37616402	286	181	285	94	44	112	50	31	49	0	0.573	1.000	1.000
263	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(19), AADAC(5), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(10), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH7A1(3), ALDH9A1(3), BDH1(4), BDH2(2), DDHD1(11), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADH(2), HADHA(3), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), HSD3B7(7), ILVBL(3), L2HGDH(6), OXCT1(7), OXCT2(2), PDHA1(5), PDHA2(29), PLA1A(6), PPME1(6), PRDX6(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	32639019	287	181	285	83	36	109	65	26	49	2	0.258	1.000	1.000
264	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(3), CALM2(1), DLG4(7), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), NOS1(29), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), SYT1(6)	20405710	243	181	237	75	45	100	48	15	33	2	0.180	1.000	1.000
265	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(7), ELK1(3), FOS(3), IKBKB(9), IRAK1(6), JUN(3), LY96(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(6), MAPK8(2), MYD88(3), NFKB1(6), NFKBIA(4), PPARA(4), RELA(3), TLR10(16), TLR2(10), TLR3(4), TLR4(64), TLR6(11), TLR7(17), TLR9(13), TOLLIP(3), TRAF6(6)	29367557	250	181	249	75	16	103	48	26	57	0	0.470	1.000	1.000
266	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(3), AKT2(7), AKT3(8), BAD(1), BTK(25), CDKN2A(23), DAPP1(3), GRB2(7), GSK3A(1), GSK3B(4), IARS(9), IGFBP1(6), INPP5D(12), PDK1(6), PIK3CA(30), PPP1R13B(7), PTEN(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SOS1(17), SOS2(13), TEC(12), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	28989848	251	180	234	50	23	105	56	19	48	0	0.00713	1.000	1.000
267	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(7), B4GALT1(1), B4GALT2(4), FBP2(2), G6PC(7), GAA(12), GALE(1), GALK1(3), GALK2(3), GALT(5), GANAB(9), GCK(7), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), LCT(50), MGAM(60), PFKM(7), PFKP(6), PGM1(3), PGM3(3)	26076697	247	179	245	72	38	108	49	17	35	0	0.0881	1.000	1.000
268	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(9), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(2), CXCR3(3), EGF(13), EGFR(87), HRAS(2), ITGA1(14), ITGB1(7), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTK2(6), PXN(2), TLN1(15)	26295190	233	179	184	57	20	69	40	44	59	1	0.248	1.000	1.000
269	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(5), CDK5(3), CDK5R1(3), CHN1(8), LIMK1(3), MAP3K1(7), MYL2(8), MYLK(26), NCF2(8), PAK1(9), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLD1(22), PPP1R12B(16), RALBP1(3), RPS6KB1(3), TRIO(37), VAV1(8), WASF1(10)	28260607	254	179	242	62	23	106	57	18	48	2	0.0550	1.000	1.000
270	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(2), CASP2(13), CASP3(5), CASP8(6), CRADD(3), DFFA(3), DFFB(4), FADD(2), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MADD(22), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), RB1(33), RIPK1(11), SPTAN1(21), TNF(2), TRADD(2), TRAF2(5)	30950025	238	179	233	48	19	59	57	26	77	0	0.0384	1.000	1.000
271	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(26), CALM1(3), CALM2(1), CREB1(2), ELK1(3), FOS(3), GNAI1(10), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), JUN(3), MAP2K1(10), MAPK3(3), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RAF1(6), RPS6KA3(6), SYT1(6)	27925393	243	178	234	63	50	100	40	17	34	2	0.0480	1.000	1.000
272	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(2), B3GALT1(5), B3GALT2(4), B3GALT4(1), B3GALT5(3), B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALNT1(10), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT6(5), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GBGT1(2), GCNT2(24), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(5), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(8), PIGU(1), PIGV(4), PIGX(4), PIGZ(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST3GAL5(3), ST3GAL6(6), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(4), ST8SIA1(6), ST8SIA5(12), UGCG(2)	38645581	284	178	275	98	41	100	62	27	54	0	0.682	1.000	1.000
273	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(26), CPS1(71), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GLS(8), GLS2(6), GLUD1(4), GLUL(6), GMPS(9), GOT1(3), GOT2(6), GPT2(5), GSS(4), NADSYN1(2), PPAT(1), QARS(7)	26707796	260	177	259	66	23	103	46	31	56	1	0.108	1.000	1.000
274	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ASL(4), ASS1(5), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), EPRS(27), GATM(8), GLUD1(4), GLUD2(15), GOT1(3), GOT2(6), LAP3(4), NOS1(29), NOS3(12), OAT(3), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), PARS2(1), PRODH(4), PYCR1(1), PYCR2(6), PYCRL(1), RARS(6), RARS2(6)	28625139	264	177	261	73	29	112	51	29	42	1	0.114	1.000	1.000
275	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(6), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(8), CDK5(3), F2(9), FYN(9), GNA11(4), GNAI1(10), GNB1(2), GNGT1(6), GRB2(7), HRAS(2), JAK2(16), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK14(6), MAPK3(3), MAPK8(2), MAPT(15), MYLK(26), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), SYT1(6)	33357943	261	176	256	76	45	87	46	29	54	0	0.229	1.000	1.000
276	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), AKR1D1(12), ARSB(6), ARSD(6), ARSE(5), CYP11B1(28), CYP11B2(24), HSD11B1(9), HSD17B2(6), HSD17B3(3), HSD3B1(6), HSD3B2(15), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2B15(14), UGT2B4(28)	22158661	259	175	256	76	21	118	65	24	30	1	0.208	1.000	1.000
277	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(8), AGXT2(13), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(8), GLDC(26), GNMT(1), HSD3B7(7), MAOA(5), MAOB(3), PEMT(2), PHGDH(7), PIPOX(2), PISD(2), PSAT1(5), PSPH(6), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SARDH(11), SARS(5), SARS2(4), SDS(4), SHMT1(2), SHMT2(2), TARS(14), TARS2(11)	34156007	252	175	251	82	37	91	53	28	42	1	0.357	1.000	1.000
278	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(26), ARHGEF1(5), F2(9), F2R(10), F2RL3(2), GNA12(2), GNA13(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), MAP3K7(10), PIK3CA(30), PIK3R1(4), PLCB1(56), PPP1R12B(16), PRKCA(10), PTK2B(14), ROCK1(19)	20726309	242	175	230	52	28	110	42	20	41	1	0.00464	1.000	1.000
279	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(25), CALM1(3), CALM2(1), CD79A(2), CD79B(2), ELK1(3), FOS(3), GRB2(7), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK14(6), MAPK3(3), MAPK8(2), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKCA(10), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8)	30760682	226	174	218	53	33	86	46	19	42	0	0.0271	1.000	1.000
280	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(2), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CFLAR(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAF1(10), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), PTPN13(21), RB1(33), RIPK2(2), SPTAN1(21)	32622253	236	173	231	57	13	60	55	28	80	0	0.396	1.000	1.000
281	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(5), B4GALT5(6), C1GALT1(6), C1GALT1C1(4), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GCNT1(8), GCNT3(2), GCNT4(9), OGT(19), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(8), WBSCR17(33)	26072743	256	172	252	94	34	98	68	22	34	0	0.941	1.000	1.000
282	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(9), ACTN1(8), ACTN2(43), BCAR1(3), BCR(11), CAPN1(2), CAPNS1(1), CAPNS2(2), CAV1(1), CRKL(4), CSK(2), FYN(9), GRB2(7), HRAS(2), ITGA1(14), ITGB1(7), JUN(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(2), PPP1R12B(16), PTK2(6), PXN(2), RAF1(6), RAP1A(1), ROCK1(19), SHC1(6), SOS1(17), SRC(2), TLN1(15), VCL(8), ZYX(6)	37582153	250	172	244	84	34	85	54	32	45	0	0.660	1.000	1.000
283	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(53), BMPR1B(7), CCND2(4), CDK4(3), CDKN1B(5), DAZL(2), DMC1(1), EGR1(6), ESR2(6), FSHR(37), GJA4(6), INHA(1), LHCGR(14), MLH1(8), MSH5(1), NCOR1(24), NR5A1(6), NRIP1(13), PGR(15), PRLR(18), PTGER2(4), SMPD1(3), VDR(4), ZP2(5)	28059230	246	172	241	55	34	88	50	28	44	2	0.0305	1.000	1.000
284	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(7), AKT3(8), ANKRD6(2), APC(33), AXIN1(7), AXIN2(5), CER1(7), CSNK1A1(2), CTNNB1(20), DACT1(24), DKK1(3), DKK2(14), DKK4(2), DVL1(5), FSTL1(4), GSK3A(1), GSK3B(4), LRP1(36), MVP(6), NKD1(6), NKD2(8), PIN1(1), PSEN1(6), PTPRA(11), SENP2(6), SFRP1(3), TSHB(5), WIF1(3)	32236645	242	172	232	73	34	105	39	21	43	0	0.354	1.000	1.000
285	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(10), CARS(4), CARS2(3), DARS(3), DARS2(4), EARS2(5), EPRS(27), FARS2(5), FARSA(5), FARSB(5), GARS(3), HARS(5), HARS2(4), IARS(9), IARS2(15), KARS(8), LARS(14), LARS2(2), MARS(6), MARS2(13), MTFMT(1), NARS(4), NARS2(6), PARS2(1), QARS(7), RARS(6), RARS2(6), SARS(5), SARS2(4), TARS(14), TARS2(11), VARS(10), VARS2(2), WARS(6), WARS2(7), YARS(3), YARS2(10)	43790134	258	171	255	63	27	94	58	26	53	0	0.0601	1.000	1.000
286	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UGDH(6), UGP2(4), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), XYLB(5)	22159835	244	170	242	67	9	118	60	22	35	0	0.327	1.000	1.000
287	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG5(1), ALG6(1), ALG8(3), ALG9(8), B4GALT1(1), B4GALT2(4), B4GALT3(2), DAD1(2), DDOST(1), DHDDS(2), DOLPP1(1), DPAGT1(5), DPM1(5), FUT8(7), GANAB(9), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(8), MGAT5(13), MGAT5B(22), RFT1(4), RPN1(3), RPN2(4), ST6GAL1(4), STT3B(4)	33965732	239	170	239	64	28	98	43	28	42	0	0.157	1.000	1.000
288	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), ELK1(3), FOS(3), GRB2(7), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PDGFA(5), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3)	28197351	223	170	208	55	26	73	46	29	48	1	0.146	1.000	1.000
289	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(4), ACTR3(2), ARHGAP1(5), ARHGAP4(14), ARHGAP5(17), ARHGAP6(21), ARHGEF1(5), ARHGEF11(25), ARHGEF5(4), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), BAIAP2(4), DIAPH1(3), GSN(4), LIMK1(3), MYL2(8), MYLK(26), OPHN1(16), PFN1(1), PIP5K1A(6), PIP5K1B(6), PPP1R12B(16), ROCK1(19), SRC(2), TLN1(15), VCL(8)	36548965	246	170	244	64	35	90	41	26	54	0	0.0560	1.000	1.000
290	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(26), AKT1(3), ASAH1(3), GNAI1(10), GNB1(2), GNGT1(6), ITGAV(14), ITGB3(17), MAPK1(2), MAPK3(3), PDGFA(5), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLCB1(56), PRKCA(10), PTK2(6), SMPD1(3), SRC(2)	22064930	243	168	231	65	24	106	51	21	39	2	0.111	1.000	1.000
291	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(3), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), AMDHD1(4), AOC2(6), AOC3(11), ASPA(5), CARM1(4), CNDP1(10), DDC(8), FTCD(11), HAL(5), HARS(5), HARS2(4), HDC(16), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), PRPS1(3), PRPS2(4), UROC1(18), WBSCR22(3)	31764646	233	168	230	69	46	78	43	24	42	0	0.135	1.000	1.000
292	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(6), ARSB(6), FUCA1(2), FUCA2(3), GALNS(3), GBA(7), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), MAN2B1(6), MAN2B2(7), MAN2C1(7), MANBA(11), NAGLU(5), NEU1(2), NEU2(7), NEU3(6), NEU4(13), SPAM1(25)	27360330	221	167	220	76	30	99	36	27	29	0	0.581	1.000	1.000
293	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(10), BAD(1), BAX(3), BCL2(5), BCL2A1(1), BCL2L1(3), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CD40(3), CD40LG(9), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(11), IKBKE(9), LTA(3), MCL1(2), NFKB1(6), NFKBIA(4), NGFR(5), NR3C1(8), NTRK1(14), PTPN13(21), RIPK1(11), TFG(4), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4), TRAF6(6)	34956034	239	166	238	89	15	98	56	28	41	1	0.941	1.000	1.000
294	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(22), CARM1(4), CCND1(3), CREBBP(30), EP300(11), ERCC3(5), ESR1(12), GRIP1(13), GTF2A1(3), GTF2E1(8), GTF2F1(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), MEF2C(6), NCOR2(30), NR0B1(14), NRIP1(13), PELP1(11), POLR2A(11), TBP(1)	36770103	252	166	252	73	38	94	64	15	41	0	0.258	1.000	1.000
295	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(12), ACAA2(2), ACADM(8), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), AOX1(22), AUH(2), BCAT1(3), BCAT2(2), BCKDHA(1), BCKDHB(14), DBT(8), DLD(9), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HADHB(10), HIBADH(2), HIBCH(4), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), OXCT2(2), PCCA(6), PCCB(3)	34662383	240	166	237	67	23	77	66	26	47	1	0.437	1.000	1.000
296	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(13), C5(6), C6(29), C7(39), ICAM1(2), IL1A(4), IL6(2), ITGA4(39), ITGAL(26), ITGB1(7), ITGB2(8), SELP(29), SELPLG(2), TNF(2), VCAM1(28)	19976575	236	166	235	69	15	102	60	23	35	1	0.464	1.000	1.000
297	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), ELAVL1(6), FLT1(31), FLT4(20), HIF1A(2), HRAS(2), KDR(56), NOS3(12), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PXN(2), SHC1(6), VHL(1)	27087280	220	166	207	57	30	90	40	21	39	0	0.108	1.000	1.000
298	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(8), AGXT2(13), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), ATP6V0C(4), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CPT1B(6), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(8), GLDC(26), MAOA(5), MAOB(3), PEMT(2), PISD(2), PLCB2(12), PLCG1(7), PLCG2(18), PSPH(6), SARDH(11), SARS(5), SHMT1(2), SHMT2(2), TARS(14)	33546941	238	165	236	81	41	77	53	30	36	1	0.525	1.000	1.000
299	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(6), CDK2(1), CDT1(3), DIAPH2(18), GMNN(1), MCM10(10), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), NACA(15), PCNA(1), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), PRIM1(3), RFC1(13), RFC2(4), RFC3(3), RFC4(7), RFC5(3), RPA1(2), RPA2(2), RPA3(1), RPA4(8), UBA52(1), UBC(14)	40583197	232	164	232	64	28	81	54	24	44	1	0.406	1.000	1.000
300	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(10), ABAT(12), ACY3(4), ADSL(2), ADSS(6), ADSSL1(4), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), ASRGL1(3), ASS1(5), CAD(26), DARS(3), DARS2(4), DDO(5), DLAT(10), DLD(9), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), NARS2(6), PC(9), PDHA1(5), PDHA2(29)	30242893	247	164	247	66	36	94	51	24	41	1	0.0876	1.000	1.000
301	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(6), CD33(13), CD5(7), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(4), IL4(1), IL5(2), ITGAX(52), TLR2(10), TLR4(64), TLR7(17), TLR9(13)	15018623	224	163	223	61	19	113	35	20	35	2	0.0233	1.000	1.000
302	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(7), AKR1B10(10), ALDOA(6), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(6), FUK(6), GMDS(9), GMPPA(8), HK1(12), HK2(11), HK3(22), HSD3B7(7), KHK(3), LHPP(3), MPI(4), MTMR1(12), MTMR2(2), MTMR6(9), PFKFB1(10), PFKFB2(2), PFKFB3(9), PFKFB4(6), PFKL(9), PFKM(7), PFKP(6), PGM2(8), PHPT1(1), PMM1(3), PMM2(1), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SORD(2), TPI1(9), TSTA3(1)	29574893	235	161	234	63	44	88	46	18	39	0	0.0324	1.000	1.000
303	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ATP6V0C(4), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADHA(3), PLOD1(5), PLOD2(13), PLOD3(10), SDS(4), SHMT1(2), SHMT2(2), TMLHE(9)	29411929	225	160	222	63	30	88	49	29	28	1	0.176	1.000	1.000
304	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(21), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(2), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHB(4), LDHC(6), LDHD(3), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(22), PDHA1(5), PDHA2(29), PKLR(16)	29693112	245	160	244	64	35	96	46	29	39	0	0.0861	1.000	1.000
305	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(7), AKT3(8), CISH(1), GRB2(7), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(10), INPP5D(12), JAK1(11), JAK2(16), JAK3(10), NR0B2(3), PI3(1), PIK3CA(30), PPP1R13B(7), RPS6KB1(3), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT6(2), TYK2(5)	29558969	208	160	194	63	23	85	47	23	30	0	0.499	1.000	1.000
306	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(10), CDC42(2), CREB1(2), DAXX(8), DDIT3(2), ELK1(3), GRB2(7), HMGN1(1), HRAS(2), HSPB1(1), HSPB2(1), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK14(6), MAPKAPK2(2), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MYC(4), PLA2G4A(21), RIPK1(11), RPS6KA5(10), SHC1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5)	29475986	225	159	224	47	21	89	47	24	44	0	0.0158	1.000	1.000
307	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(5), ALOX12(8), ALOX15(5), ALOX5(10), CYP4F2(15), CYP4F3(16), EPX(14), GGT1(1), LPO(7), LTA4H(3), MPO(15), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), PTGDS(4), PTGIS(12), PTGS1(19), PTGS2(12), TBXAS1(11), TPO(35)	22337017	243	159	239	75	40	82	61	25	35	0	0.289	1.000	1.000
308	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(22), EEF1A2(8), EEF1B2(7), EEF1D(5), EEF1G(2), EEF2(7), EEF2K(7), EIF1AX(3), EIF2AK1(12), EIF2AK2(5), EIF2AK3(12), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4EBP2(1), EIF4G1(19), EIF4G3(20), EIF5(1), EIF5A(2), EIF5B(14), GSPT2(8), PABPC1(5), PABPC3(15), PAIP1(6), SLC35A4(1)	34830836	213	157	212	53	17	81	56	25	34	0	0.173	1.000	1.000
309	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2F1(4), GTF2H1(4), GTF2H3(1), GTF2H4(1), GTF2I(7), GTF2IRD1(11), STON1(11), TAF1(22), TAF1L(65), TAF2(13), TAF4(13), TAF4B(6), TAF5(5), TAF5L(9), TAF6(4), TAF6L(3), TAF7(3), TAF7L(6), TAF9(3), TAF9B(5), TBPL1(1), TBPL2(5)	29022582	217	155	217	51	27	78	51	16	44	1	0.137	1.000	1.000
310	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(17), DIAPH1(3), FYN(9), GSN(4), HRAS(2), ITGA1(14), ITGB1(7), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PFN1(1), PIK3CA(30), PIK3R1(4), PTK2(6), PXN(2), RAF1(6), ROCK1(19), SHC1(6), SRC(2), TLN1(15)	30127071	196	153	183	54	22	75	37	26	36	0	0.298	1.000	1.000
311	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1B10(10), AKR1C4(4), AKR1D1(12), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), HSD3B7(7), LIPA(2), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SLC27A5(7), SOAT1(8), SOAT2(2), SRD5A1(4)	25394461	206	153	203	63	19	84	48	22	33	0	0.368	1.000	1.000
312	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(6), ARSE(5), ASAH1(3), B4GALT6(5), CERK(4), DEGS1(2), DEGS2(1), ENPP7(11), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(6), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SGMS1(4), SGMS2(3), SGPP1(3), SGPP2(2), SMPD1(3), SMPD3(6), SMPD4(13), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(2), UGT8(8)	28419660	212	153	210	69	37	100	42	11	22	0	0.262	1.000	1.000
313	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), COMT(1), DBH(12), DCT(16), DDC(8), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), MAOA(5), MAOB(3), PNMT(1), TAT(9), TH(7), TPO(35), TYR(29)	25458965	249	153	246	80	39	101	35	28	46	0	0.278	1.000	1.000
314	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(26), AKT1(3), CAMK2A(3), CAMK2B(16), CAMK2D(8), CREB1(2), GNAS(29), GRB2(7), HRAS(2), MAPK1(2), MAPK14(6), MAPK3(3), PIK3CA(30), PIK3R1(4), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RPS6KA1(6), RPS6KA5(10), SOS1(17)	23289810	210	151	194	57	36	83	40	22	27	2	0.277	1.000	1.000
315	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(10), F2RL3(2), GNAI1(10), GNB1(2), GNGT1(6), HRAS(2), ITGA1(14), ITGB1(7), MAP2K1(10), MAPK1(2), MAPK3(3), PLA2G4A(21), PLCB1(56), PRKCA(10), PTGS1(19), PTK2(6), RAF1(6), SRC(2), SYK(5), TBXAS1(11)	19547606	213	151	208	47	22	96	43	21	31	0	0.0118	1.000	1.000
316	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(9), AGT(4), AGTR1(9), AGTR2(6), CMA1(8), COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), REN(6)	20378769	234	149	233	81	20	133	35	13	32	1	0.955	1.000	1.000
317	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(7), GHR(19), GRB2(7), HRAS(2), INSR(10), IRS1(20), JAK2(16), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTPN6(6), RAF1(6), RPS6KA1(6), SHC1(6), SLC2A4(4), SOS1(17), SRF(1), STAT5A(3), STAT5B(8)	26607771	204	149	189	52	29	77	45	25	28	0	0.0842	1.000	1.000
318	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(12), ACACA(21), ACACB(28), ACADM(8), ACAT1(2), ACAT2(2), ACSS1(5), ACSS2(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), HIBCH(4), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	31991829	205	149	204	71	26	75	44	17	43	0	0.863	1.000	1.000
319	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(5), FOS(3), GRB2(7), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MPL(6), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), THPO(9)	24178108	184	149	169	45	20	64	35	26	39	0	0.179	1.000	1.000
320	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(4), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), LIMK1(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), NOX1(8), PIK3C2G(19), PLCB1(56), PPP1R12B(16), PRKCA(10), PTK2(6), RAF1(6), ROCK2(9)	20171859	206	148	199	45	32	87	40	19	28	0	0.0359	1.000	1.000
321	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(10), ADCY3(7), ADCY9(12), ARF1(1), ARF3(1), ARF5(2), ARF6(1), ARL4D(4), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), ERO1L(5), GNAS(29), PDIA4(8), PLCG1(7), PLCG2(18), PRKCA(10), SEC61A1(5), SEC61A2(6), SEC61G(3), TRIM23(4)	29658651	203	148	197	65	34	79	40	15	34	1	0.408	1.000	1.000
322	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(10), BCR(11), BLNK(2), ELK1(3), FOS(3), GRB2(7), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8IP3(7), PAPPA(32), RPS6KA1(6), RPS6KA3(6), SHC1(6), SOS1(17), SYK(5), VAV1(8), VAV2(8), VAV3(32)	25525164	196	148	192	50	25	71	39	24	36	1	0.0915	1.000	1.000
323	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(19), POLA2(7), POLB(4), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLG(12), POLG2(3), POLH(1), POLI(3), POLK(3), POLL(7), POLM(7), POLQ(36), PRIM1(3), PRIM2(14), REV1(10), REV3L(20), RFC5(3)	32635969	199	147	198	49	22	82	47	23	24	1	0.193	1.000	1.000
324	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BAD(1), BRAF(44), CREB1(2), CREB3(1), CREB5(18), DUSP4(2), DUSP6(4), DUSP9(6), EEF2K(7), EIF4E(4), GRB2(7), MAP2K1(10), MAP2K2(1), MAP3K8(5), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MOS(9), NFKB1(6), RAP1A(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), SHC1(6), SOS1(17), SOS2(13), TRAF3(4)	23617530	200	147	174	40	22	79	47	15	36	1	0.00776	1.000	1.000
325	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(11), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GPHN(5), NSF(4), SRC(2), UBQLN1(6)	9626774	188	146	185	62	23	91	33	19	22	0	0.612	1.000	1.000
326	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(13), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9)	18346764	204	145	197	56	41	73	39	12	37	2	0.219	1.000	1.000
327	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(13), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9)	18346764	204	145	197	56	41	73	39	12	37	2	0.219	1.000	1.000
328	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), BTRC(12), CDC16(2), CDC20(8), CDC23(4), CDC27(7), CUL1(14), CUL2(8), CUL3(13), FBXW11(2), FBXW7(17), FZR1(3), ITCH(8), SKP1(4), SKP2(4), SMURF1(8), SMURF2(4), TCEB1(2), TCEB2(1), UBA1(4), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(4), UBE2E3(6), VHL(1), WWP1(13), WWP2(7)	32170628	204	145	203	48	28	63	43	32	38	0	0.0833	1.000	1.000
329	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(7), AKT3(8), BAD(1), BCL2(5), GRB2(7), GSK3A(1), GSK3B(4), IL4R(10), IRS1(20), JAK1(11), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PPP1R13B(7), RAF1(6), SHC1(6), SOS1(17), SOS2(13), STAT6(2)	28596494	199	145	184	62	24	80	45	20	30	0	0.523	1.000	1.000
330	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(3), AKT2(7), AKT3(8), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PIK3CB(8), PITX2(8), PLD1(22), PLD2(7), PLD3(4), VN1R1(2)	35811416	212	145	211	57	24	80	43	19	45	1	0.171	1.000	1.000
331	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(3), CA1(6), CA12(2), CA13(1), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(5), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), HAL(5)	17120398	184	144	183	58	17	80	31	23	33	0	0.574	1.000	1.000
332	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(16), CAMK2D(8), DAG1(3), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFAT5(13), PDE6A(17), PDE6B(15), PDE6C(12), PDE6G(3), SLC6A13(12), TF(13)	28645135	205	144	204	63	28	73	49	20	34	1	0.424	1.000	1.000
333	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(18), AGT(4), AGTR2(6), EDN1(1), EDNRA(3), EDNRB(17), EGF(13), EGFR(87), FOS(3), HRAS(2), JUN(3), MYC(4), NFKB1(6), PLCG1(7), PRKCA(10), RELA(3)	16592775	187	143	138	37	18	47	30	40	52	0	0.0684	1.000	1.000
334	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BAD(1), BCL2(5), BCL2L1(3), CBL(10), CFLAR(2), CRKL(4), E2F1(3), FOS(3), GRB2(7), HRAS(2), IL2RA(6), IL2RB(7), IL2RG(5), IRS1(20), JAK1(11), JAK3(10), MAPK1(2), MAPK3(3), MYC(4), NMI(2), PIK3CA(30), PIK3R1(4), PTPN6(6), RAF1(6), RPS6KB1(3), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5)	28960398	201	143	186	60	28	72	51	23	27	0	0.392	1.000	1.000
335	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), AOX1(22), BCAT1(3), BCKDHA(1), BCKDHB(14), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), HIBADH(2), HMGCL(1), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), PCCA(6), PCCB(3), SDS(4)	28978649	194	143	192	57	16	67	47	25	39	0	0.586	1.000	1.000
336	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(13), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), ATP7A(29), ATP7B(22), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6C(1), COX7A2(1), COX8A(1), NDUFA1(2), NDUFA10(5), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(3), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1), SDHA(8), SDHB(1), SHMT1(2), UQCRB(5), UQCRC1(2), UQCRFS1(3), UQCRH(3)	30733115	209	142	206	79	34	80	31	21	41	2	0.822	1.000	1.000
337	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(12), ACADL(4), ACADM(8), ACADSB(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), MLYCD(2), SDS(4), SMS(3), UPB1(2)	23401329	213	141	211	54	26	84	39	22	41	1	0.0603	1.000	1.000
338	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(1), CDC42(2), CREB1(2), CREB3(1), CREB5(18), DUSP1(1), DUSP10(11), EEF2K(7), EIF4E(4), ELK1(3), GADD45A(2), HSPB1(1), IL1R1(2), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K10(4), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(6), MAPKAPK2(2), MAPKAPK5(5), MKNK1(4), MKNK2(2), MYEF2(12), NFKB1(6), NR2C2(2), SRF(1), TRAF6(6)	26680683	184	141	182	45	16	76	36	15	41	0	0.105	1.000	1.000
339	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), P4HB(5), SLC23A1(4), SLC23A2(8), SLC2A1(1), SLC2A3(10)	20161255	220	141	219	71	23	120	34	10	32	1	0.744	1.000	1.000
340	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(5), C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20), MASP1(24), MASP2(8), MBL2(13)	17155255	201	140	199	59	20	94	36	18	32	1	0.365	1.000	1.000
341	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(10), CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), HDAC5(5), IGF1(4), IGF1R(8), INSR(10), MAP2K6(5), MAPK14(6), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), NFATC1(11), NFATC2(15), PIK3CA(30), PIK3R1(4), PPP3CA(14), PPP3CB(4), PPP3CC(3), SYT1(6), YWHAH(1)	27758602	174	140	160	48	21	73	29	16	35	0	0.117	1.000	1.000
342	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(5), CREBBP(30), EP300(11), FYN(9), IL2RG(5), IL7(2), IL7R(21), JAK1(11), JAK3(10), LCK(13), NMI(2), PIK3CA(30), PIK3R1(4), PTK2B(14), STAT5A(3), STAT5B(8)	22465484	178	140	168	50	23	65	38	19	33	0	0.291	1.000	1.000
343	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(33), AXIN1(7), CREBBP(30), CTNNB1(20), DVL1(5), EP300(11), FZD1(6), GSK3B(4), HDAC1(4), LDB1(3), LEF1(12), PITX2(8), TRRAP(51), WNT1(6)	26615618	200	140	191	40	40	65	41	17	37	0	0.00489	1.000	1.000
344	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(19), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HMGCL(1), L2HGDH(6), OXCT1(7), PDHA1(5), PDHA2(29), SDHB(1), SDS(4)	20733189	194	139	193	53	26	73	40	20	34	1	0.193	1.000	1.000
345	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), GHR(19), IRS1(20), MAPK1(2), MAPK14(6), MAPK3(3), MKNK1(4), PABPC1(5), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PRKCA(10), PTEN(11), RPS6KB1(3)	22744566	183	138	171	49	16	80	43	17	27	0	0.340	1.000	1.000
346	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(5), ACO2(3), CLYBL(5), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), OGDHL(35), PC(9), PCK1(22), PCK2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	24111107	172	138	171	64	28	63	24	25	32	0	0.712	1.000	1.000
347	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(9), EPHA4(18), EPHB1(44), FYN(9), ITGA1(14), ITGB1(7), L1CAM(42), LYN(6), RAP1B(2), SELP(29)	12772799	180	137	179	47	28	68	34	22	26	2	0.118	1.000	1.000
348	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(12), ACACA(21), ACADL(4), ACADM(8), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), LDHA(10), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SDS(4), SUCLA2(5), SUCLG1(5), SUCLG2(1)	26690520	183	137	182	51	19	63	41	19	41	0	0.455	1.000	1.000
349	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(5), BCR(11), CRKL(4), FOS(3), GRB2(7), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), MYC(4), PIK3CA(30), PIK3R1(4), RAF1(6), SOS1(17), STAT1(7), STAT5A(3), STAT5B(8)	22565531	163	136	147	35	15	57	42	21	28	0	0.0432	1.000	1.000
350	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(2), ANXA3(6), ANXA4(5), ANXA5(6), ANXA6(8), CYP11A1(5), EDN1(1), EDNRA(3), EDNRB(17), HPGD(5), HSD11B1(9), PLA2G4A(21), PRL(3), PTGDR(8), PTGDS(4), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), PTGIS(12), PTGS1(19), PTGS2(12), S100A6(1), SCGB1A1(2), TBXAS1(11)	16642391	190	136	188	47	28	67	44	17	32	2	0.0502	1.000	1.000
351	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(5), C3(13), C5(6), C6(29), C7(39), C8A(18), C8B(20), C9(20), MASP1(24)	16788403	200	135	198	55	19	93	36	21	30	1	0.218	1.000	1.000
352	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(3), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(6), CYP3A7(7), CYP4B1(14), CYP51A1(5), PON1(4)	23543387	192	134	192	72	25	77	38	23	29	0	0.765	1.000	1.000
353	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GPX1(5), PRKCE(5), SOD1(1)	6364786	171	133	168	55	18	87	30	16	19	1	0.517	1.000	1.000
354	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), ADC(2), AGMAT(2), ALDH18A1(3), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), ASS1(5), CPS1(71), GATM(8), MAOA(5), MAOB(3), NAGS(1), ODC1(1), OTC(10), SAT1(3), SMS(3), SRM(2)	23626242	182	133	181	62	23	69	35	25	29	1	0.637	1.000	1.000
355	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(12), ACADM(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HIBCH(4), MLYCD(2), SMS(3), SRM(2), UPB1(2)	21711201	196	133	194	50	26	78	39	17	35	1	0.0685	1.000	1.000
356	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(6), CA12(2), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(5), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUL(6), HAL(5)	15322390	165	133	164	49	17	67	27	22	32	0	0.451	1.000	1.000
357	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), AZIN1(4), BTG1(3), CBX3(4), CLOCK(4), CRY1(7), CRY2(6), DAZAP2(1), DNAJA1(3), EIF4G2(5), ETV6(5), GFRA1(20), GSTM3(2), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(11), NCKAP1(11), NCOA4(6), NR1D2(1), PER1(10), PER2(12), PPP1R3C(3), PPP2CB(3), PSMA4(2), PURA(2), SF3A3(2), SUMO3(5), TOB1(4), TUBB3(3), UGP2(4), VAPA(2), ZFR(10)	29207628	174	132	173	44	20	60	39	16	38	1	0.258	1.000	1.000
358	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(7), ICAM1(2), ITGA4(39), ITGAL(26), ITGAM(24), ITGB1(7), ITGB2(8), SELE(17), SELL(9), SELP(29)	12885072	168	131	166	51	11	82	40	12	23	0	0.520	1.000	1.000
359	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(17), ARHGEF1(5), GNA12(2), GNA13(6), GNAQ(5), GNB1(2), GNGT1(6), MYL2(8), MYLK(26), PLCB1(56), PPP1R12B(16), PRKCA(10), ROCK1(19)	16694901	178	131	177	43	19	77	29	21	32	0	0.0862	1.000	1.000
360	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(33), AXIN1(7), BTRC(12), CCND1(3), CREBBP(30), CSNK1A1(2), CSNK1D(7), CSNK2A1(5), CTBP1(3), CTNNB1(20), DVL1(5), FZD1(6), GSK3B(4), HDAC1(4), MAP3K7(10), MYC(4), NLK(3), PPARD(6), PPP2CA(1), TLE1(5), WIF1(3), WNT1(6)	23421841	179	131	170	33	29	68	33	16	33	0	0.00441	1.000	1.000
361	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(5), CHIA(5), CHIT1(11), CMAS(10), CYB5R1(1), GFPT1(8), GFPT2(10), GNE(2), GNPDA1(2), GNPDA2(2), GNPNAT1(1), HEXA(6), HK1(12), HK2(11), HK3(22), LHPP(3), MTMR1(12), MTMR2(2), MTMR6(9), NAGK(6), NANS(2), NPL(4), PGM3(3), PHPT1(1), RENBP(7), UAP1(7)	23026251	164	130	163	43	30	63	28	19	24	0	0.106	1.000	1.000
362	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(8), EXT2(12), EXTL1(8), EXTL2(3), EXTL3(13), GLCE(4), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(4), HS6ST3(12), NDST1(6), NDST2(6), NDST3(16), NDST4(36)	16652374	174	130	172	50	32	58	42	23	17	2	0.230	1.000	1.000
363	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(3), BLVRB(2), CP(11), CPOX(4), EPRS(27), FECH(4), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), PPOX(7), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2B15(14), UGT2B4(28), UROS(2)	22183495	182	130	181	52	9	88	48	12	25	0	0.391	1.000	1.000
364	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(8), ACTN2(43), BCAR1(3), CSK(2), CTNNA1(10), CTNNA2(66), CTNNB1(20), PTK2(6), PXN(2), SRC(2), VCL(8)	15247578	170	129	162	50	19	72	34	19	26	0	0.215	1.000	1.000
365	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(3), CALM2(1), CRKL(4), GNAQ(5), GRB2(7), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK14(6), MAPK3(3), MAPK8(2), PAK1(9), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6)	22790036	157	129	150	46	24	53	30	13	37	0	0.441	1.000	1.000
366	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(6), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME3(8), PGK1(4), PGK2(27), PKLR(16), RPE(3), RPIA(8), TKT(3), TKTL1(14), TKTL2(26), TPI1(9)	16185365	161	128	161	34	18	64	33	18	28	0	0.00756	1.000	1.000
367	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(7), FADD(2), IKBKB(9), IL1A(4), IL1R1(2), IRAK1(6), MAP3K1(7), MAP3K7(10), MYD88(3), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TLR4(64), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF6(6)	19518685	156	128	155	49	5	66	35	19	31	0	0.621	1.000	1.000
368	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(2), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(6), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK5(5), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PIK3CA(30), PIK3CD(4), PIK3R1(4), SYT1(6), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6)	26390548	151	127	141	50	19	53	29	17	33	0	0.561	1.000	1.000
369	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(5), ELK1(3), FOS(3), GRB2(7), HRAS(2), IGF1(4), IGF1R(8), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1)	20012310	154	126	139	38	17	58	31	18	30	0	0.169	1.000	1.000
370	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(2), EIF4A2(7), EIF4B(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), MKNK1(4), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3), TSC1(10), TSC2(13)	22071035	152	126	140	39	12	58	40	14	28	0	0.298	1.000	1.000
371	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CRK(1), CXCL12(8), CXCR4(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(19), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PTK2B(14), PXN(2), RAF1(6), RELA(3)	22098127	165	125	152	43	18	73	31	16	27	0	0.139	1.000	1.000
372	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(29), F2(9), F2R(10), FGA(20), FGB(18), FGG(4), PLAT(12), PLAU(3), PLG(32), SERPINB2(14), SERPINE1(14)	10835018	171	124	166	49	14	89	33	9	26	0	0.372	1.000	1.000
373	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(5), ELK1(3), FOS(3), GRB2(7), HRAS(2), INSR(10), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SLC2A4(4), SOS1(17), SRF(1)	20534203	156	124	141	43	19	54	34	21	28	0	0.321	1.000	1.000
374	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(25), DLG4(7), EPHB2(11), F2(9), F2RL1(2), F2RL2(12), F2RL3(2), JUN(3), MAP2K5(4), MAPK1(2), MAPK7(7), MAPK8(2), MYEF2(12), PLD1(22), PLD2(7), PLD3(4), PTK2(6), RAF1(6), RASAL1(10), SRC(2), TEC(12), VAV1(8)	21952267	175	124	173	36	22	71	41	8	33	0	0.00433	1.000	1.000
375	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(5), ATG5(3), ATG7(6), BECN1(1), GABARAPL1(2), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNG(7), PIK3C3(14), PIK3R4(22), PRKAA1(7), PRKAA2(8), ULK1(8), ULK2(9), ULK3(2)	16775574	157	123	155	36	11	76	34	15	20	1	0.111	1.000	1.000
376	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(9), F2R(10), F3(3), F5(40), F7(10), FGA(20), FGB(18), FGG(4), PROC(4), PROS1(30), SERPINC1(5), TFPI(5)	13160754	163	122	161	41	13	82	26	11	31	0	0.185	1.000	1.000
377	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(3), DAB1(34), FYN(9), LRP8(6), RELN(104), VLDLR(5)	11327920	164	122	163	50	17	62	41	14	30	0	0.607	1.000	1.000
378	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(7), ALDOA(6), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(6), GCK(7), GMDS(9), GMPPA(8), HK1(12), HK2(11), HK3(22), KHK(3), MPI(4), PFKFB1(10), PFKFB3(9), PFKFB4(6), PFKM(7), PFKP(6), PMM1(3), PMM2(1), SORD(2), TPI1(9)	19170829	162	121	162	37	31	59	31	13	28	0	0.00716	1.000	1.000
379	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(11), ABCG2(15), BCHE(35), CES1(8), CES2(1), CYP3A4(4), CYP3A5(6), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7)	18509913	157	121	156	56	12	71	38	16	20	0	0.735	1.000	1.000
380	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(2), DLAT(10), DLD(9), DLST(5), FH(13), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), PC(9), PDHA1(5), PDHA2(29), PDHX(4), PDK1(6), PDK2(3), PDK3(5), PDK4(2), PDP2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	22875222	160	121	159	51	24	63	23	22	28	0	0.499	1.000	1.000
381	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(26), AKT1(3), BAD(1), BAX(3), BCL2(5), BCL2L1(3), CSF2RB(14), IGF1(4), IGF1R(8), IL3(4), IL3RA(8), KIT(12), KITLG(6), PIK3CA(30), PIK3R1(4), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), YWHAH(1)	17624187	158	120	147	53	14	71	38	12	21	2	0.602	1.000	1.000
382	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(4), ALDH3A1(5), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), ESCO1(10), ESCO2(4), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), NAT6(1), PNPLA3(4), PRDX6(5), TAT(9), TPO(35)	27575749	164	120	163	67	31	54	31	20	28	0	0.941	1.000	1.000
383	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(11), AGPAT6(5), AGPS(6), CHPT1(3), ENPP2(19), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(22), PLD2(7), PPAP2A(2), PPAP2B(3), PPAP2C(1)	18600534	161	120	160	38	18	68	29	12	34	0	0.0343	1.000	1.000
384	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(6), ARSD(6), ARSE(5), ASAH1(3), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(6), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SMPD1(3), SPTLC1(3), SPTLC2(3), UGCG(2)	19347418	152	119	151	45	24	75	28	8	17	0	0.186	1.000	1.000
385	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), NAGLU(5), SPAM1(25)	16293964	144	118	143	48	17	67	20	22	18	0	0.524	1.000	1.000
386	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), E2F1(3), HRAS(2), MAPK1(2), MAPK3(3), NFKB1(6), NFKBIA(4), PAK1(9), PIK3CA(30), PIK3R1(4), RAF1(6), RB1(33), RELA(3), TFDP1(11)	16217036	145	118	128	30	11	48	26	9	51	0	0.0796	1.000	1.000
387	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(12), ADSL(2), ADSS(6), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), CAD(26), DARS(3), DDO(5), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), PC(9)	20822772	158	117	158	48	22	56	28	19	32	1	0.329	1.000	1.000
388	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1C4(4), AKR1D1(12), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), SOAT2(2), SRD5A1(4)	18668477	161	117	158	45	12	69	37	19	24	0	0.233	1.000	1.000
389	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(7), CREBBP(30), DUSP1(1), EP300(11), IKBKB(9), IL1B(1), MAP2K3(13), MAP2K6(5), MAP3K7(10), MAPK14(6), MYD88(3), NFKB1(6), NFKBIA(4), NR3C1(8), RELA(3), TGFBR1(7), TGFBR2(7), TLR2(10), TNF(2)	23832807	143	117	142	43	12	49	30	13	39	0	0.597	1.000	1.000
390	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(9), ACTN1(8), ACTN2(43), CAPN1(2), CAPNS1(1), CAPNS2(2), ITGA1(14), ITGB1(7), ITGB3(17), PTK2(6), PXN(2), SPTAN1(21), SRC(2), TLN1(15)	22874847	149	117	148	52	17	54	38	19	21	0	0.705	1.000	1.000
391	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(5), C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20)	14117892	156	116	155	45	16	69	30	16	24	1	0.396	1.000	1.000
392	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(7), IFNA1(2), IFNB1(7), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL1RN(3), IL6(2), IRAK1(6), IRAK2(6), IRAK3(6), JUN(3), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(6), MAPK8(2), MYD88(3), NFKB1(6), NFKBIA(4), RELA(3), TGFB1(3), TGFB2(10), TNF(2), TOLLIP(3), TRAF6(6)	23848641	145	116	144	51	7	51	31	18	38	0	0.899	1.000	1.000
393	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(33), ASAH1(3), CAMP(4), CASP3(5), CERK(4), CREB1(2), CREB3(1), CREB5(18), CXCL2(1), DAG1(3), EPHB2(11), FOS(3), GNAQ(5), ITPKA(2), ITPKB(7), JUN(3), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8)	22589372	151	116	150	34	21	49	30	9	42	0	0.0626	1.000	1.000
394	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(9), ADCY1(26), CCNB1(2), CDC25C(8), GNAI1(10), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), MAPK1(2), MAPK3(3), MYT1(24), PIN1(1), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RPS6KA1(6), SRC(2)	16355330	158	115	155	50	33	60	28	10	25	2	0.378	1.000	1.000
395	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(12), BAIAP2(4), CASP1(8), CASP3(5), CASP7(3), CASP8(6), GAPDH(5), INSR(10), ITCH(8), MAGI1(21), MAGI2(33), RERE(12), WWP1(13), WWP2(7)	19234129	147	114	146	41	16	64	21	14	32	0	0.367	1.000	1.000
396	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3A1(5), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TAT(9), TPO(35)	17678811	152	114	151	62	30	50	28	20	24	0	0.842	1.000	1.000
397	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(3), CALM2(1), CHUK(7), EGR2(4), EGR3(1), GNAQ(5), MAP3K1(7), MYC(4), NFATC1(11), NFATC2(15), NFKB1(6), NFKBIA(4), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(6), VIP(6), VIPR2(3)	22435877	140	114	137	40	20	55	23	14	27	1	0.282	1.000	1.000
398	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2B1(6), MAN2B2(7), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(6), NEU4(13)	16216807	129	113	128	41	21	61	23	9	15	0	0.325	1.000	1.000
399	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(10), ALOX15(5), ALOX5(10), CYP1A2(3), CYP2C18(7), CYP2C19(13), CYP2C8(3), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP3A4(4), CYP3A43(6), CYP3A5(6), CYP3A7(7), HSD3B7(7), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	19242354	157	113	156	60	17	70	37	15	18	0	0.804	1.000	1.000
400	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(10), GLB1(3), HEXA(6), LCT(50), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(3), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(4), ST8SIA1(6), ST8SIA5(12)	13265083	134	113	133	48	24	50	27	12	21	0	0.601	1.000	1.000
401	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(16), ACE2(9), AGT(4), AGTR1(9), AGTR2(6), ANPEP(10), CMA1(8), CPA3(16), CTSA(4), CTSG(12), ENPEP(18), LNPEP(5), MAS1(5), MME(20), NLN(7), REN(6), THOP1(8)	16967000	163	113	162	64	21	72	28	18	23	1	0.813	1.000	1.000
402	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(10), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), GAS2(10), LMNA(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), SPTAN1(21), TNFRSF10B(3), TNFRSF25(2), TNFSF10(3), TRADD(2), TRAF2(5)	26779656	145	112	145	56	8	52	38	16	31	0	0.970	1.000	1.000
403	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(6), ALDOB(8), ALDOC(2), DERA(4), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKL(9), PFKM(7), PFKP(6), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TALDO1(2), TKT(3), TKTL1(14), TKTL2(26)	19391436	139	112	139	36	16	47	31	18	27	0	0.110	1.000	1.000
404	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(5), ELK1(3), FOS(3), GRB2(7), HRAS(2), IL6(2), IL6R(8), IL6ST(3), JAK1(11), JAK2(16), JAK3(10), JUN(3), MAP2K1(10), MAPK3(3), PTPN11(9), RAF1(6), SHC1(6), SOS1(17), SRF(1), STAT3(11)	18997736	136	112	131	35	16	37	32	24	27	0	0.252	1.000	1.000
405	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(33), CDH1(6), CREBBP(30), EP300(11), MAP2K1(10), MAP3K7(10), MAPK3(3), SKIL(11), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7)	20740652	141	112	138	25	14	50	28	14	35	0	0.0268	1.000	1.000
406	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(4), DARS(3), EPRS(27), FARS2(5), GARS(3), HARS(5), IARS(9), KARS(8), LARS(14), LARS2(2), MARS(6), MARS2(13), NARS(4), QARS(7), RARS(6), SARS(5), TARS(14), WARS(6), WARS2(7), YARS(3)	25898121	156	111	156	38	12	59	36	20	29	0	0.201	1.000	1.000
407	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(3), CR1(34), CR2(20), FCGR2B(7), HLA-DRA(3), HLA-DRB1(5), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41)	12281228	149	111	144	48	11	63	28	10	37	0	0.776	1.000	1.000
408	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(9), HLA-A(8), ITGB1(7), KLRC1(5), KLRC2(4), KLRC3(3), KLRC4(1), KLRD1(2), LAT(4), MAP2K1(10), MAPK3(3), PAK1(9), PIK3CA(30), PIK3R1(4), PTK2B(14), PTPN6(6), SYK(5), VAV1(8)	14993870	132	110	117	29	21	47	19	16	29	0	0.0506	1.000	1.000
409	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(9), DYRK1B(6), GLI2(28), GLI3(39), GSK3B(4), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SHH(2), SMO(17), SUFU(3)	13336116	134	110	132	37	34	47	27	8	17	1	0.134	1.000	1.000
410	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(22), BST1(3), CD38(4), ENPP1(14), ENPP3(19), NADK(5), NADSYN1(2), NMNAT1(3), NMNAT2(8), NMNAT3(1), NNMT(7), NNT(11), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5C3(1), NT5E(5), NT5M(3), NUDT12(7), QPRT(3)	17307368	144	109	142	41	15	52	22	22	33	0	0.394	1.000	1.000
411	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2H1(4), GTF2H4(1), ILK(1), MNAT1(2), POLR1A(13), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3B(20), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(2), TAF5(5), TAF6(4), TAF7(3), TAF9(3), TBP(1)	28239498	138	109	138	49	22	40	40	14	21	1	0.906	1.000	1.000
412	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(5), ELK1(3), FOS(3), GRB2(7), HRAS(2), IL2(7), IL2RA(6), IL2RB(7), IL2RG(5), JAK1(11), JAK3(10), JUN(3), LCK(13), MAP2K1(10), MAPK3(3), MAPK8(2), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5)	18686649	142	108	137	38	17	48	30	20	27	0	0.209	1.000	1.000
413	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(19), APOA1(3), APOA4(12), APOC1(3), APOC2(2), APOC3(2), APOE(1), CETP(8), CYP7A1(8), DGAT1(1), HMGCR(5), LCAT(6), LDLR(10), LIPC(9), LPL(8), LRP1(36), SCARB1(6), SOAT1(8)	21987629	147	108	143	54	22	50	27	19	29	0	0.833	1.000	1.000
414	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(3), CALM2(1), CDKN1A(2), GNAQ(5), MARCKS(2), NFATC1(11), NFATC2(15), NFATC3(16), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKCA(10), SP1(6), SP3(6), SYT1(6)	16789317	122	107	119	36	20	51	21	8	22	0	0.297	1.000	1.000
415	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(4), CHAT(22), COMT(1), DBH(12), DDC(8), GAD1(7), GAD2(27), HDC(16), MAOA(5), PAH(11), PNMT(1), SLC18A3(19), TH(7), TPH1(8)	11438375	149	106	148	53	23	60	25	10	31	0	0.592	1.000	1.000
416	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(8), APC(33), AXIN1(7), BTRC(12), CTNNB1(20), DLL1(5), DVL1(5), FZD1(6), GSK3B(4), NOTCH1(26), PSEN1(6), WNT1(6)	16636417	138	106	130	26	28	48	23	13	26	0	0.00891	1.000	1.000
417	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(2), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CD28(5), CD4(8), CXCR3(3), CXCR4(6), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL4(1), IL4R(10), IL5(2), TGFB1(3), TGFB2(10)	16147480	132	105	132	34	14	53	21	14	29	1	0.103	1.000	1.000
418	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX1(5), GPX3(3), GPX4(1), GPX5(7), GPX6(7), GPX7(4), GSR(5), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(6), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(3), OPLAH(10), TXNDC12(2)	17465013	137	104	138	24	18	53	20	10	36	0	0.000416	1.000	1.000
419	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(24), AP2A1(4), AP2M1(5), BIN1(4), CALM1(3), CALM2(1), DNM1(11), EPN1(11), EPS15(7), PICALM(6), PPP3CA(14), PPP3CB(4), PPP3CC(3), SYNJ1(14), SYNJ2(10), SYT1(6)	17322327	127	104	123	41	16	46	26	11	28	0	0.749	1.000	1.000
420	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20)	10140162	125	103	124	37	12	55	26	11	20	1	0.578	1.000	1.000
421	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(18), DDX20(5), E2F1(3), E2F4(5), ETS1(8), ETS2(6), ETV3(2), FOS(3), HDAC2(8), HDAC5(5), HRAS(2), JUN(3), NCOR2(30), RBL1(7), RBL2(5), SIN3A(12), SIN3B(2)	20506999	125	103	125	43	15	35	34	17	24	0	0.761	1.000	1.000
422	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(11), ASPA(5), CNDP1(10), DDC(8), HAL(5), HARS(5), HDC(16), MAOA(5), MAOB(3), PRPS1(3), PRPS2(4)	19703306	137	103	137	40	25	46	24	18	24	0	0.187	1.000	1.000
423	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(6), GALNT10(6), GALNT2(11), GALNT3(12), GALNT6(5), GALNT7(9), GALNT8(19), GCNT1(8), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), WBSCR17(33)	11655898	121	103	120	58	14	49	29	15	14	0	0.995	1.000	1.000
424	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(11), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(6), UGT1A7(7), UGT1A8(5), UGT1A9(7), UGT2B15(14), UGT2B4(28)	14237894	132	103	131	41	6	59	36	13	18	0	0.555	1.000	1.000
425	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(12), ESR2(6), ITPKA(2), PDE1A(17), PDE1B(13), PLCB1(56), PLCB2(12), PRL(3), TRH(4), VIP(6)	8866426	131	103	129	30	19	55	25	11	21	0	0.0335	1.000	1.000
426	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(7), AKT3(8), BPNT1(7), GRB2(7), ILK(1), MAPK1(2), MAPK3(3), PDK1(6), PIK3CA(30), PIK3CD(4), PTEN(11), PTK2B(14), RBL2(5), SHC1(6), SOS1(17)	16368664	131	103	118	34	13	57	32	12	17	0	0.266	1.000	1.000
427	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(7), FOS(3), HRAS(2), JUN(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYC(4), NFKB1(6), NFKBIA(4), PLCB1(56), PRKCA(10), RAF1(6), RELA(3), TNF(2)	12532437	121	102	116	31	14	51	21	14	21	0	0.120	1.000	1.000
428	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(4), CBS(1), CTH(2), GGT1(1), LCMT1(5), LCMT2(7), MARS(6), MARS2(13), MAT1A(7), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(5), PAPSS2(10), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), SCLY(4), SEPHS1(4), SEPHS2(2), WBSCR22(3)	20010499	127	102	125	50	22	42	27	14	22	0	0.853	1.000	1.000
429	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(2), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), ILVBL(3), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCDC(2), PPCS(2), UPB1(2), VNN1(10)	13820415	128	102	125	34	14	60	18	15	20	1	0.207	1.000	1.000
430	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(6), NEU4(13)	13180834	116	102	115	35	18	58	20	7	13	0	0.267	1.000	1.000
431	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(8), GTF2F1(4), HDAC3(3), NCOA1(18), NCOA2(22), NCOA3(14), NCOR2(30), POLR2A(11), RARA(7), RXRA(1), TBP(1)	19823020	128	102	128	39	17	43	33	19	16	0	0.510	1.000	1.000
432	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), BAD(1), GRB2(7), HRAS(2), IGF1R(8), IRS1(20), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3CA(30), PIK3R1(4), RAF1(6), SHC1(6), SOS1(17), YWHAH(1)	15299323	120	101	104	26	13	52	26	13	16	0	0.0616	1.000	1.000
433	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), GATM(8), GLUD1(4), NAGS(1), OAT(3), ODC1(1), OTC(10), PYCR1(1), SMS(3)	13907447	122	101	121	44	12	47	22	18	22	1	0.811	1.000	1.000
434	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BAD(1), BCL2L1(3), CASP9(6), CDC42(2), CHUK(7), ELK1(3), H2AFX(3), HRAS(2), MAP2K1(10), MAPK3(3), NFKB1(6), PIK3CA(30), PIK3R1(4), RAF1(6), RALA(5), RALBP1(3), RALGDS(5), RELA(3), RHOA(4)	15259168	109	100	95	25	7	48	22	14	18	0	0.106	1.000	1.000
435	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(13), CHUK(7), CRADD(3), IKBKB(9), JUN(3), LTA(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP4K2(4), MAPK14(6), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(4), TNF(2), TRADD(2), TRAF2(5)	19246618	121	100	121	41	9	43	26	12	31	0	0.747	1.000	1.000
436	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(45), ABCB11(28), ABCB4(19), ABCC1(14), ABCC3(13), GSTP1(2)	11611517	121	99	120	35	11	48	27	11	24	0	0.309	1.000	1.000
437	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(4), AKT1(3), ANXA1(1), CALM1(3), CALM2(1), GNAS(29), GNB1(2), GNGT1(6), NFKB1(6), NOS3(12), NPPA(3), NR3C1(8), PIK3CA(30), PIK3R1(4), RELA(3), SYT1(6)	14240325	121	98	107	29	17	52	24	8	20	0	0.151	1.000	1.000
438	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(10), CALM1(3), CALM2(1), CAPN2(5), CAPNS1(1), CAPNS2(2), EP300(11), HDAC1(4), HDAC2(8), MEF2D(4), NFATC1(11), NFATC2(15), PPP3CA(14), PPP3CB(4), PPP3CC(3), PRKCA(10), SYT1(6)	19557403	112	98	109	38	22	41	14	9	26	0	0.560	1.000	1.000
439	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(2), PAK1(9), PDGFRA(41), PIK3CA(30), PIK3R1(4), WASL(7)	10832772	111	97	99	31	8	42	24	11	25	1	0.594	1.000	1.000
440	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(2), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(6), MARS2(13), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(1), MTR(22), SRM(2), TAT(9)	16605481	121	97	121	41	18	44	22	12	25	0	0.658	1.000	1.000
441	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(7), ICAM1(2), ITGA4(39), ITGAL(26), ITGB1(7), ITGB2(8), SELE(17), SELL(9)	9773661	115	97	113	31	6	55	28	9	17	0	0.407	1.000	1.000
442	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), ACO2(3), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), PC(9), PCK1(22), SDHA(8), SDHB(1), SUCLA2(5), SUCLG1(5), SUCLG2(1)	16611796	112	96	111	45	18	40	12	18	24	0	0.862	1.000	1.000
443	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(26), CREM(6), FHL5(15), FSHB(4), FSHR(37), GNAS(29), XPO1(12)	7620498	129	96	125	42	25	55	24	10	14	1	0.746	1.000	1.000
444	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(5), B3GAT2(10), CHPF(10), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST3(1), CHST7(2), CHSY1(5), DSE(19), UST(5), XYLT1(44), XYLT2(3)	11111541	117	96	115	48	29	31	28	12	17	0	0.774	1.000	1.000
445	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(5), ELK1(3), EPO(6), EPOR(2), FOS(3), GRB2(7), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PLCG1(7), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8)	17270267	115	95	110	23	19	34	26	15	21	0	0.0284	1.000	1.000
446	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CYP2C19(13), CYP2C9(8), DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1)	24862284	116	95	115	35	13	42	29	13	19	0	0.555	1.000	1.000
447	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), GBA3(1), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TPO(35), TYR(29)	7742906	113	95	112	43	18	41	25	12	17	0	0.754	1.000	1.000
448	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(3), MRPS7(5), RPL10A(2), RPL10L(16), RPL11(2), RPL13A(2), RPL14(3), RPL19(2), RPL21(1), RPL22L1(3), RPL23A(2), RPL24(1), RPL27A(2), RPL28(4), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL36A(2), RPL36AL(1), RPL37(2), RPL3L(8), RPL41(1), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPS10(1), RPS11(1), RPS13(1), RPS16(5), RPS18(2), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS7(1), RPSA(1)	17937359	115	94	110	30	17	37	21	14	26	0	0.256	1.000	1.000
449	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCS(2), UPB1(2)	11120123	111	94	108	31	10	52	16	13	19	1	0.390	1.000	1.000
450	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), CREB1(2), GRB2(7), HRAS(2), MAPK1(2), MAPK3(3), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), NTRK1(14), PIK3CA(30), PIK3R1(4), PLCG1(7), RPS6KA1(6), SHC1(6)	15227173	107	93	95	25	16	44	23	9	14	1	0.0750	1.000	1.000
451	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(5), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CMBL(1), CYP3A4(4), CYP3A43(6), CYP3A5(6), CYP3A7(7), DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), PON1(4), PON2(2), PON3(4)	14444794	109	93	109	41	5	45	23	15	21	0	0.794	1.000	1.000
452	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), GRB2(7), HRAS(2), KLK2(11), NTRK1(14), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), SHC1(6), SOS1(17)	12562243	111	93	97	30	13	47	25	10	15	1	0.309	1.000	1.000
453	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(3), GRB2(7), HRAS(2), IL3(4), IL3RA(8), JAK2(16), MAP2K1(10), MAPK3(3), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8)	14173710	113	92	108	26	17	38	28	15	15	0	0.0703	1.000	1.000
454	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(4), AP2M1(5), ARF1(1), BAD(1), BTK(25), EEA1(5), GSK3A(1), GSK3B(4), LYN(6), PDPK1(3), PFKL(9), PFKM(7), PFKP(6), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(8)	19805791	109	92	108	26	12	33	28	12	23	1	0.152	1.000	1.000
455	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(26), ADRB2(4), GNAS(29), PLCE1(29), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAP2B(2)	11785893	116	91	112	39	27	44	19	8	15	3	0.591	1.000	1.000
456	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(4), CASP3(5), CASP8(6), CFLAR(2), FADD(2), JUN(3), MAP2K4(8), MAP3K3(10), MAP3K7(10), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR2C2(2), RALBP1(3), RIPK1(11), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF2(5)	21702517	106	91	105	34	9	40	24	7	26	0	0.675	1.000	1.000
457	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(6), GPLD1(10), PGAP1(8), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(5), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(8), PIGU(1), PIGV(4), PIGW(2), PIGX(4), PIGZ(3)	19033646	114	90	113	48	13	38	28	15	20	0	0.939	1.000	1.000
458	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(28), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15)	7379109	111	89	110	40	12	43	26	13	16	1	0.573	1.000	1.000
459	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PPP2CA(1), PRKAA1(7), PRKAA2(8), PRKAB1(3), PRKACB(11), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	12237886	114	89	111	38	26	39	25	7	15	2	0.717	1.000	1.000
460	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(28), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15)	7379109	111	89	110	40	12	43	26	13	16	1	0.573	1.000	1.000
461	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GCNT2(24), ST3GAL6(6), ST8SIA1(6)	12770463	99	89	91	27	11	41	17	9	21	0	0.210	1.000	1.000
462	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(15), AMT(1), ATIC(7), DHFR(2), FTCD(11), GART(9), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3)	15191954	103	89	101	25	16	42	12	7	26	0	0.101	1.000	1.000
463	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(33), MAP2(49), PPP1CA(3), PPP2CA(1), PRKACB(11), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2), PRKCE(5)	14641764	112	88	111	27	9	43	29	15	14	2	0.460	1.000	1.000
464	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(1), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), DDOST(1), DPAGT1(5), DPM1(5), FUT8(7), MAN1A1(3), MAN1B1(4), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(8), MGAT5(13), RPN1(3), RPN2(4), ST6GAL1(4)	15889813	105	88	105	30	19	44	14	11	17	0	0.214	1.000	1.000
465	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(8), CAMK4(16), HDAC5(5), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PPARA(4), PPP3CA(14), PPP3CB(4), PPP3CC(3), SLC2A4(4), SYT1(6), YWHAH(1)	16155923	105	88	102	23	10	38	18	12	27	0	0.0900	1.000	1.000
466	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(3), CDKN1B(5), GRB2(7), ILK(1), ITGB1(7), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PTEN(11), PTK2(6), SHC1(6), SOS1(17)	15476399	111	88	98	27	8	45	26	14	18	0	0.263	1.000	1.000
467	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), BAD(1), CASP9(6), CHUK(7), GH1(7), GHR(19), NFKB1(6), NFKBIA(4), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), RELA(3), YWHAH(1)	11357153	95	87	84	28	2	47	18	9	19	0	0.573	1.000	1.000
468	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), ZNRD1(1)	18917469	107	87	107	35	16	35	31	9	16	0	0.744	1.000	1.000
469	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD28(5), CD3D(2), CD3E(2), CD4(8), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6)	9079402	106	87	106	36	11	39	24	6	26	0	0.664	1.000	1.000
470	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(10), CHUK(7), IFNG(7), IKBKB(9), IL2(7), IL4(1), JUN(3), MAP3K1(7), MAP3K5(14), MAP4K5(2), MAPK14(6), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), TNFRSF9(7), TNFSF9(3), TRAF2(5)	15554068	103	86	103	29	7	32	18	11	34	1	0.631	1.000	1.000
471	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(10), ARHGDIB(2), BIRC2(2), BIRC3(4), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), GZMB(8), LMNA(2), LMNB1(5), LMNB2(5), PRF1(8)	15507295	112	86	111	31	3	47	25	13	24	0	0.483	1.000	1.000
472	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(6), IL22(4), IL22RA1(7), IL22RA2(6), JAK1(11), JAK2(16), JAK3(10), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), TYK2(5)	14605481	94	86	94	28	8	24	21	18	23	0	0.584	1.000	1.000
473	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(8), JAK1(11), JAK2(16), JAK3(10), PIAS3(7), PTPRU(19), REG1A(20), SRC(2), STAT3(11)	12181194	107	86	105	33	12	36	21	14	24	0	0.422	1.000	1.000
474	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), BAD(1), CHRNB1(5), CHRNG(7), MUSK(12), PIK3CA(30), PIK3R1(4), PTK2(6), PTK2B(14), RAPSN(3), SRC(2), TERT(7), YWHAH(1)	13086207	95	85	84	24	12	40	19	10	14	0	0.0995	1.000	1.000
475	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), NCK1(5), NCKAP1(11), NTRK1(14), PIR(4), PSMA7(6), WASF1(10), WASF2(3), WASF3(14), WASL(7)	12318169	101	85	99	35	13	32	22	10	23	1	0.821	1.000	1.000
476	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(10), GCK(7), GFPT1(8), GNE(2), GNPDA1(2), GNPDA2(2), HEXA(6), HK1(12), HK2(11), HK3(22), PGM3(3), RENBP(7), UAP1(7)	13601954	99	85	99	33	23	37	13	11	15	0	0.505	1.000	1.000
477	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3D(2), CD3E(2), CXCR3(3), ETV5(6), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), JAK2(16), JUN(3), MAP2K6(5), MAPK14(6), MAPK8(2), STAT4(11), TYK2(5)	14944366	109	85	109	24	10	35	21	13	29	1	0.115	1.000	1.000
478	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(15), CNR2(3), DNMT1(8), MTNR1A(15), MTNR1B(13), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), TBXA2R(1)	8843339	97	85	96	40	20	31	19	13	13	1	0.693	1.000	1.000
479	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BAX(3), BCL2(5), CASP8(6), CYCS(2), FADD(2), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(10), RAF1(6), RELA(3), RIPK1(11), SMPD1(3), TRADD(2), TRAF2(5)	16473660	97	84	94	34	11	34	27	11	14	0	0.752	1.000	1.000
480	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2S2(3), EIF2S3(3), EIF4E(4), GSK3B(4), IGF1(4), IGF1R(8), INPPL1(11), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3)	15858521	98	84	87	22	8	47	19	9	15	0	0.116	1.000	1.000
481	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(4), CAT(3), EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), SHMT1(2), SHMT2(2), TPO(35)	9442451	96	84	94	38	18	33	18	12	15	0	0.771	1.000	1.000
482	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(6), MARS2(13), MAT1A(7), MAT2B(3), MTR(22)	13939418	105	84	105	34	13	37	20	12	23	0	0.547	1.000	1.000
483	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(15), AMT(1), ATIC(7), ATP6V0C(4), DHFR(2), GART(9), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3)	14411684	95	84	93	22	14	37	11	8	25	0	0.0784	1.000	1.000
484	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(22), CD38(4), ENPP1(14), ENPP3(19), NADSYN1(2), NMNAT1(3), NMNAT2(8), NNMT(7), NNT(11), NT5E(5), NT5M(3), QPRT(3)	11710641	101	83	99	32	11	40	11	18	21	0	0.584	1.000	1.000
485	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(26), ADRB2(4), CFTR(11), GNAS(29), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(1)	10408581	97	82	94	33	24	37	16	6	11	3	0.668	1.000	1.000
486	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36)	13406889	100	82	99	30	14	39	25	10	12	0	0.487	1.000	1.000
487	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX1(5), GPX3(3), GPX4(1), GPX5(7), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(6), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(3), PGD(2)	14510190	104	82	104	19	14	40	13	7	30	0	0.00352	1.000	1.000
488	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD28(5), CD3D(2), CD3E(2), CD8A(4), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6)	8651043	102	82	102	38	12	35	25	5	25	0	0.816	1.000	1.000
489	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(5), CD86(11), HLA-DRA(3), HLA-DRB1(5), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL2RA(6), IL4(1), IL4R(10)	10203446	103	82	99	30	10	38	15	8	31	1	0.538	1.000	1.000
490	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(30), EP300(11), LPL(8), NCOA1(18), NCOA2(22), PPARG(8), RXRA(1)	14903897	98	81	98	19	14	34	21	11	18	0	0.0377	1.000	1.000
491	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(12), KHK(3), LCT(50), MPI(4), PGM1(3), PYGL(6), PYGM(9), TPI1(9), TREH(1)	10753455	97	80	96	29	15	44	23	5	10	0	0.218	1.000	1.000
492	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(7), ICAM1(2), ITGAL(26), ITGAM(24), ITGB2(8), SELE(17), SELL(9)	8386806	93	80	91	35	8	45	24	4	12	0	0.741	1.000	1.000
493	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD3E(2), CD4(8), FYN(9), HLA-DRA(3), HLA-DRB1(5), LCK(13), PTPRC(41), ZAP70(9)	7299922	92	80	88	28	11	31	16	5	29	0	0.639	1.000	1.000
494	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(12), IL13(2), IL4(1), IL5(2), JUNB(1), MAF(4), MAP2K3(13), MAPK14(6), NFATC1(11), NFATC2(15), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	9567274	93	79	92	32	16	38	17	5	16	1	0.501	1.000	1.000
495	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), IDS(7), IDUA(1), LCT(50), NAGLU(5)	11432703	87	78	86	30	13	43	10	9	12	0	0.536	1.000	1.000
496	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(6), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKM(7), PFKP(6), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TAL1(7), TALDO1(2), TKT(3)	16397956	93	78	93	26	12	30	19	14	18	0	0.249	1.000	1.000
497	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREB1(2), CREBBP(30), EP300(11), NCOA3(14), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RARA(7), RXRA(1)	16607315	95	77	95	21	14	37	21	8	14	1	0.101	1.000	1.000
498	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(4), CYP51A1(5), DHCR24(3), DHCR7(6), EBP(3), FDFT1(4), FDPS(5), GGCX(7), GGPS1(2), HMGCR(5), HSD17B7(3), IDI1(2), IDI2(1), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4), TM7SF2(6), VKORC1(4)	15429563	89	77	87	26	15	25	21	12	16	0	0.364	1.000	1.000
499	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(2), IARS(9), IARS2(15), ILVBL(3), LARS(14), LARS2(2), PDHA1(5), PDHA2(29), VARS(10), VARS2(2)	14999013	94	77	93	26	13	35	15	11	20	0	0.334	1.000	1.000
500	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(3), GOSR1(2), GOSR2(4), SNAP23(3), SNAP25(5), SNAP29(1), STX11(3), STX12(3), STX16(5), STX17(4), STX18(3), STX19(3), STX2(8), STX3(6), STX4(1), STX5(3), STX6(3), STX7(3), STX8(2), TSNARE1(8), USE1(2), VAMP3(1), VAMP4(2), VAMP5(1), VAMP7(7), VAMP8(1), VTI1A(2), VTI1B(1), YKT6(1)	13367893	93	77	93	23	7	29	21	12	23	1	0.239	1.000	1.000
501	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(21), CPT1A(11), LEP(4), LEPR(26), PRKAA1(7), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5)	11717314	86	77	85	28	9	29	24	6	18	0	0.768	1.000	1.000
502	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4)	20146303	96	76	93	30	6	42	21	8	19	0	0.635	1.000	1.000
503	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(3), EPX(14), LPO(7), MPO(15), MTHFR(7), PRDX6(5), SHMT1(2), SHMT2(2), TPO(35)	9328337	92	76	91	38	19	33	16	9	15	0	0.823	1.000	1.000
504	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(7), CREBBP(30), EP300(11), FADD(2), HDAC3(3), IKBKB(9), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF6(6)	17978878	98	76	98	33	11	30	23	11	23	0	0.718	1.000	1.000
505	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(7), GBA3(1), LPO(7), MPO(15), PRDX6(5), TPO(35)	6754499	84	75	83	38	16	29	16	9	14	0	0.929	1.000	1.000
506	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3)	12061465	83	74	81	31	15	24	20	9	15	0	0.761	1.000	1.000
507	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3)	10651830	86	73	83	24	7	42	17	6	14	0	0.296	1.000	1.000
508	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(5), NFKB1(6), NFKBIA(4), PLCB1(56), PRKCA(10), RELA(3)	6638404	84	73	83	25	7	40	13	9	15	0	0.477	1.000	1.000
509	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(11), JAK2(16), JAK3(10), PIAS1(2), PIAS3(7), PTPRU(19), REG1A(20), SOAT1(8)	10944552	94	72	92	28	13	33	16	11	21	0	0.392	1.000	1.000
510	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), LTA(3), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(4), TNFAIP3(6), TNFRSF1B(2), TRAF1(2), TRAF2(5), TRAF3(4)	18085983	80	71	80	34	8	25	21	10	16	0	0.962	1.000	1.000
511	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(4), IFNB1(7), JAK1(11), PTPRU(19), REG1A(20), STAT1(7), STAT2(6), TYK2(5)	10025136	79	70	77	18	9	37	8	10	15	0	0.0398	1.000	1.000
512	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(22), CHKA(4), PCYT1A(2), PDHA1(5), PDHA2(29), PEMT(2), SLC18A3(19)	5570894	87	69	86	35	19	38	15	3	12	0	0.756	1.000	1.000
513	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(21), ACACB(28), FASN(18), MCAT(3), OLAH(8), OXSM(5)	12381899	83	69	83	27	15	32	15	7	14	0	0.487	1.000	1.000
514	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(4), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), CHST1(17), CHST2(14), CHST4(3), CHST6(7), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4)	9963065	85	69	84	41	14	31	21	6	13	0	0.950	1.000	1.000
515	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(9), APAF1(10), BCL2(5), CASP3(5), CASP9(6), CYCS(2), DAXX(8), FAS(4), FASLG(11), HSPB1(1), HSPB2(1), IL1A(4), MAPKAPK2(2), MAPKAPK3(3), TNF(2)	9129702	73	69	73	29	2	34	18	11	8	0	0.906	1.000	1.000
516	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(6), AOC3(11), CES1(8), DDHD1(11), ESCO1(10), ESCO2(4), LIPA(2), NAT6(1), PLA1A(6), PNPLA3(4), PPME1(6), PRDX6(5)	20439259	79	68	79	24	12	24	17	13	13	0	0.565	1.000	1.000
517	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(3), CALM2(1), CCL2(2), CCL4(2), CCR5(4), CXCL12(8), CXCR4(6), FOS(3), GNAQ(5), JUN(3), MAPK14(6), MAPK8(2), PLCG1(7), PRKCA(10), PTK2B(14), SYT1(6)	11118315	82	66	82	24	11	32	12	9	18	0	0.389	1.000	1.000
518	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(5), PRMT2(3), PRMT3(8), PRMT5(8), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3)	11287042	78	66	76	29	15	21	19	9	14	0	0.787	1.000	1.000
519	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(10), ARHGAP5(17), ARHGDIB(2), CASP1(8), CASP10(7), CASP3(5), CASP8(6), CASP9(6), CYCS(2), GZMB(8), JUN(3), PRF1(8)	10442703	82	65	82	24	2	37	17	14	12	0	0.628	1.000	1.000
520	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(7), IL2RG(5), IL4(1), IL4R(10), IRS1(20), JAK1(11), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(2)	11837408	78	65	77	27	15	27	14	11	11	0	0.617	1.000	1.000
521	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(49), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), YWHAH(1)	6195060	74	65	74	24	8	29	14	6	15	2	0.601	1.000	1.000
522	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(8), ACADS(1), ACADVL(2), ACSL1(12), ACSL3(4), ACSL4(7), CPT1A(11), CPT2(3), EHHADH(13), HADHA(3), PECR(3), SCP2(4), SLC25A20(1)	13533556	76	64	75	18	11	23	13	13	16	0	0.195	1.000	1.000
523	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(10), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP7(3), CASP8(6), CASP9(6), DFFA(3), DFFB(4), GZMB(8), PRF1(8), SCAP(6), SREBF1(5), SREBF2(2)	14452849	79	64	79	20	0	29	20	12	18	0	0.345	1.000	1.000
524	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(9), CD3D(2), CD3E(2), GZMB(8), HLA-A(8), ICAM1(2), ITGAL(26), ITGB2(8), PRF1(8)	7018562	73	63	72	24	7	22	17	9	18	0	0.501	1.000	1.000
525	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(8), ENO1(7), GPI(8), HK1(12), PFKL(9), PGAM1(1), PGK1(4), PKLR(16), TPI1(9)	7359403	74	63	74	25	13	24	19	5	13	0	0.482	1.000	1.000
526	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(12), GPR161(6), GPR171(2), GPR18(4), GPR34(5), GPR39(6), GPR45(14), GPR65(14), GPR68(1), GPR75(5)	7970124	74	63	73	23	9	29	24	4	8	0	0.376	1.000	1.000
527	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(16), CD44(7), CSF1(1), FCGR3A(7), IL1B(1), IL6R(8), SELL(9), SPN(4), TGFB1(3), TGFB2(10), TNF(2), TNFRSF1B(2), TNFRSF8(11), TNFSF8(1)	10550242	82	63	80	30	7	42	15	6	12	0	0.560	1.000	1.000
528	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(5), ARFGAP3(5), ARFGEF2(14), CLTA(1), COPA(14), GBF1(17), GPLD1(10), KDELR1(1), KDELR2(1), KDELR3(3)	13048441	72	62	72	17	7	25	18	11	11	0	0.206	1.000	1.000
529	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(9), CYP11A1(5), CYP11B2(24), CYP17A1(6), HSD11B1(9), HSD3B1(6), HSD3B2(15)	5575349	74	62	73	29	13	28	16	6	10	1	0.567	1.000	1.000
530	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(3), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), SDS(4), SULT1B1(10), SULT1C2(3), SULT1C4(2), SULT4A1(6)	10064685	67	61	67	24	6	32	11	5	13	0	0.790	1.000	1.000
531	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(8), CAMK4(16), CAMKK1(5), CAMKK2(3), CREB1(2), SYT1(6)	9210287	66	60	66	18	5	26	11	7	17	0	0.346	1.000	1.000
532	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(5), DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(11), IDI1(2), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4)	10504983	67	60	65	20	11	18	16	7	14	1	0.497	1.000	1.000
533	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(7), CRY2(6), CSNK1D(7), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(10), PER2(12), PER3(11)	13642370	73	60	71	17	8	28	17	6	13	1	0.201	1.000	1.000
534	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(8), UBE2A(7), UBE2B(1), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2E3(6), UBE2G2(1), UBE2I(3), UBE2J1(3), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(18)	8388658	64	60	63	20	6	28	12	6	12	0	0.577	1.000	1.000
535	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(29), GNB1(2), GNGT1(6), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10)	7619071	75	59	72	21	23	28	12	5	6	1	0.429	1.000	1.000
536	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3)	5218640	69	59	68	35	20	18	15	7	9	0	0.908	1.000	1.000
537	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3)	5218640	69	59	68	35	20	18	15	7	9	0	0.908	1.000	1.000
538	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(3), AFMID(4), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2)	10822334	63	59	62	25	8	22	11	8	14	0	0.768	1.000	1.000
539	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(7), COPS5(3), CREB1(2), EDN1(1), EP300(11), EPO(6), HIF1A(2), JUN(3), LDHA(10), NOS3(12), P4HB(5), VHL(1)	13589874	68	58	68	21	4	19	18	4	23	0	0.748	1.000	1.000
540	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), BLVRB(2), HMOX1(3), IL10(2), IL10RA(6), IL10RB(6), IL1A(4), IL6(2), JAK1(11), STAT1(7), STAT3(11), STAT5A(3), TNF(2)	9843447	62	58	62	17	4	15	15	13	15	0	0.536	1.000	1.000
541	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), DIABLO(1)	10829222	65	58	65	25	2	26	17	6	14	0	0.950	1.000	1.000
542	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PRKACA(3), PRKAR1A(2)	5210467	68	57	65	24	22	23	11	4	6	2	0.704	1.000	1.000
543	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(6)	8572537	61	57	61	31	10	22	17	5	7	0	0.945	1.000	1.000
544	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(2), ACOT11(4), ACYP2(1), DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), FN3K(1), GCDH(7), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1)	20889072	72	57	70	23	9	23	19	8	13	0	0.692	1.000	1.000
545	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(9), ANKRD1(6), CYR61(2), DUSP14(2), EIF4E(4), IFNG(7), IFRD1(4), IL1A(4), IL1R1(2), JUND(1), MYOG(1), NR4A3(9), WDR1(9)	8580866	60	57	60	17	4	19	16	8	12	1	0.562	1.000	1.000
546	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(6), CTSD(5), ESR1(12), GREB1(33), HSPB1(1), HSPB2(1), MTA1(6), MTA3(2), PDZK1(3), TUBA8(1)	8607341	70	57	69	23	14	24	15	3	14	0	0.329	1.000	1.000
547	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(30), EP300(11), ESR1(12), MAPK1(2), MAPK3(3), PELP1(11), SRC(2)	11815841	71	57	71	17	14	25	17	3	12	0	0.134	1.000	1.000
548	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(6)	8067073	60	56	60	29	7	21	18	5	9	0	0.925	1.000	1.000
549	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), FDXR(3), SHMT1(2)	12868967	65	56	64	28	9	28	8	7	12	1	0.869	1.000	1.000
550	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(4), FOSL2(3), IFNAR1(4), IFNAR2(7), IFNB1(7), MAPK8(2), NFKB1(6), RELA(3), TNFRSF11A(9), TNFSF11(5), TRAF6(6)	8948107	59	56	59	16	4	22	14	6	13	0	0.481	1.000	1.000
551	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(3), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2)	10332673	59	55	58	23	6	20	11	8	14	0	0.769	1.000	1.000
552	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(16), AGT(4), AGTR1(9), AGTR2(6), BDKRB2(3), KNG1(9), NOS3(12), REN(6)	7816341	65	54	65	34	8	32	11	6	8	0	0.929	1.000	1.000
553	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), TNFAIP3(6), TRAF3(4), TRAF6(6)	14639467	59	54	59	29	5	18	14	7	15	0	0.991	1.000	1.000
554	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(6), ACOX3(8), FADS2(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3)	8123278	68	54	68	24	7	28	17	8	8	0	0.683	1.000	1.000
555	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	62	53	61	24	9	26	8	7	11	1	0.724	1.000	1.000
556	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), CREM(6), FOS(3), JUN(3), MAPK3(3), OPRK1(12), POLR2A(11), PRKACB(11), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	10358187	66	53	66	27	12	24	16	6	7	1	0.875	1.000	1.000
557	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(2), EPO(6), EPOR(2), GRIN1(9), HIF1A(2), JAK2(16), NFKB1(6), NFKBIA(4), RELA(3), SOD2(6)	10072951	61	53	60	20	3	20	18	5	15	0	0.749	1.000	1.000
558	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	62	53	61	24	9	26	8	7	11	1	0.724	1.000	1.000
559	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(7), HK1(12), HK2(11), HK3(22), IMPA1(2), IMPA2(1), ISYNA1(1), PGM1(3), PGM3(3), TGDS(1)	9290356	63	53	63	27	17	20	12	6	8	0	0.823	1.000	1.000
560	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(4), MMP2(24), MMP9(10), RECK(9), TIMP1(5), TIMP2(2), TIMP3(4), TIMP4(4)	6044842	64	53	64	22	12	23	15	4	10	0	0.557	1.000	1.000
561	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(11), JAK2(16), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(5)	9257582	58	53	58	21	7	15	13	12	11	0	0.789	1.000	1.000
562	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	62	53	61	24	9	26	8	7	11	1	0.724	1.000	1.000
563	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(4), FUT2(1), FUT9(15), GCNT2(24), ST8SIA1(6)	4888396	53	52	45	19	5	21	8	4	15	0	0.701	1.000	1.000
564	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), NAT1(4), NAT2(5), XDH(18)	6470567	56	52	56	23	7	28	10	7	4	0	0.633	1.000	1.000
565	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), SIRT1(2), SIRT2(2), SIRT5(1), SIRT7(4), VNN2(14)	9526617	56	52	54	15	8	19	13	5	11	0	0.436	1.000	1.000
566	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(6), ACOX3(8), ELOVL2(6), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(18), HADHA(3), HSD17B12(4), PECR(3), SCD(3)	11182281	58	52	58	14	10	23	10	8	7	0	0.150	1.000	1.000
567	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8)	10638297	57	52	57	20	7	19	16	5	10	0	0.749	1.000	1.000
568	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(7), HK1(12), HK2(11), HK3(22), IMPA1(2), PGM1(3), PGM3(3), TGDS(1)	8218088	61	52	61	26	17	20	12	5	7	0	0.843	1.000	1.000
569	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), CKM(4), EIF4E(4), FBL(8), LDHA(10), LDHB(4), LDHC(6), MAPK14(6), NCL(10)	7183673	62	51	62	17	9	24	8	8	13	0	0.423	1.000	1.000
570	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(2), GGT1(1), MARS(6), MARS2(13), MAT1A(7), MAT2B(3), PAPSS1(5), PAPSS2(10), SCLY(4), SEPHS1(4)	9934310	57	51	57	27	7	23	10	6	11	0	0.935	1.000	1.000
571	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(6), DHFR(2), HPRT1(1), IMPDH1(7), MTHFD2(2), OAZ1(1), POLB(4), POLD1(7), POLG(12), PRPS2(4), RRM1(6), SRM(2)	9912415	56	50	56	13	8	19	11	9	9	0	0.223	1.000	1.000
572	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(6), PSMB1(2), PSMB5(1), PSMB6(1), PSMD14(2), RPN1(3), RPN2(4), UBE2A(7), UBE3A(18)	10426013	58	50	58	13	5	24	14	9	6	0	0.216	1.000	1.000
573	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(9), LARS(14), LARS2(2), PDHA1(5), PDHA2(29)	8106531	62	50	62	19	9	26	9	7	11	0	0.669	1.000	1.000
574	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(10), DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), HSD3B7(7), PON1(4), PON2(2), PON3(4), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	7249371	52	49	52	18	5	24	12	3	8	0	0.565	1.000	1.000
575	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), IDI1(2), LSS(10), MVD(2), MVK(4), NQO2(3), PMVK(2), SQLE(4), VKORC1(4)	8778102	51	48	49	18	11	12	11	9	8	0	0.675	1.000	1.000
576	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(5), ACO2(3), ACSS1(5), ACSS2(4), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SUCLA2(5)	10748299	52	48	52	20	5	16	5	10	16	0	0.777	1.000	1.000
577	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(10), BAD(1), BAK1(3), BAX(3), BCL10(4), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), CASP9(6), CES1(8)	8626031	49	48	49	22	5	23	11	6	4	0	0.966	1.000	1.000
578	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(4), IFNAR2(7), IFNB1(7), JAK1(11), STAT1(7), STAT2(6), TYK2(5)	8678322	49	47	49	12	4	19	9	9	8	0	0.319	1.000	1.000
579	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(5), GSR(5), GSS(4), NFKB1(6), NOX1(8), RELA(3), SOD1(1), TNF(2), XDH(18)	8029467	52	46	52	22	5	24	11	6	6	0	0.849	1.000	1.000
580	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(6), PSMB1(2), PSMB5(1), PSMB6(1), PSMC2(3), PSMD1(8), PSMD11(7), PSMD12(4), PSMD13(4), PSMD2(3), PSMD6(2)	12929204	55	46	55	10	5	29	10	5	6	0	0.0921	1.000	1.000
581	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(11), LDLR(10), MBTPS1(7), MBTPS2(7), SCAP(6), SREBF1(5), SREBF2(2)	9331112	48	45	48	14	5	15	14	4	8	2	0.514	1.000	1.000
582	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(2), FH(13), IDH2(2), MDH1(3), OGDH(10), SDHA(8), SUCLA2(5)	7617727	46	44	45	16	7	14	7	6	12	0	0.607	1.000	1.000
583	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), KARS(8)	5621956	50	44	50	17	5	25	9	7	4	0	0.754	1.000	1.000
584	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(12), GAD1(7), HDC(16), PNMT(1), TH(7), TPH1(8)	4758284	51	43	51	18	10	20	9	3	9	0	0.524	1.000	1.000
585	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CSK(2), GRB2(7), PRKCA(10), PTPRA(11), SRC(2)	7390964	47	43	47	17	8	17	8	5	9	0	0.654	1.000	1.000
586	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(7), MAPK14(6), MAPK8(2), NFKB1(6), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFSF13B(1), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6)	11647677	50	43	50	26	5	13	9	8	15	0	0.994	1.000	1.000
587	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(2), WASF1(10), WASL(7)	6550870	46	42	46	18	4	13	13	6	10	0	0.887	1.000	1.000
588	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(2), CAPNS1(1), CAPNS2(2), CDK5(3), CDK5R1(3), CSNK1A1(2), CSNK1D(7), GSK3B(4), MAPT(15), PPP2CA(1)	7346627	49	41	49	19	8	22	9	4	6	0	0.785	1.000	1.000
589	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), ACO2(3), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SDHB(1), SUCLA2(5)	7200223	41	39	41	15	3	14	3	8	13	0	0.715	1.000	1.000
590	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(2), ALAS2(6), CPO(4), FECH(4), GATA1(6), HBA2(2), HBB(9), HMBS(5), UROS(2)	6361596	41	38	41	25	2	22	8	3	6	0	0.992	1.000	1.000
591	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(19), GNA12(2), PRKACB(11), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2)	8129650	42	37	42	12	6	15	11	4	6	0	0.617	1.000	1.000
592	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(2), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(11), HMGCS2(7), OXCT1(7), OXCT2(2)	5814519	38	36	38	15	3	12	12	3	7	1	0.896	1.000	1.000
593	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4)	6322492	39	36	38	22	6	13	9	2	9	0	0.970	1.000	1.000
594	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHB(4), LDHC(6)	5511713	35	33	35	12	4	13	5	4	9	0	0.720	1.000	1.000
595	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(7), EIF2S2(3), EIF2S3(3), EIF5(1), GSK3B(4), PPP1CA(3)	9270131	33	33	33	12	2	15	5	3	8	0	0.863	1.000	1.000
596	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(8), CD8A(4), CSF1(1), EPO(6), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), IL9(1)	4807995	38	33	38	14	1	18	7	4	8	0	0.696	1.000	1.000
597	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(14), BCKDK(2), CBS(1), CTH(2), MUT(13)	3908921	32	32	31	15	3	11	6	4	8	0	0.928	1.000	1.000
598	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(10), NR0B2(3), NR1H3(4), NR1H4(14), RXRA(1)	4348769	35	31	35	13	7	13	9	2	4	0	0.640	1.000	1.000
599	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), CYCS(2), GPD2(9), NDUFA1(2), SDHA(8), SDHB(1), SDHD(3), UQCRC1(2)	5355877	31	30	30	17	8	11	8	0	4	0	0.982	1.000	1.000
600	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(1), APOBEC2(1), APOBEC3A(3), APOBEC3B(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(5), APOBEC4(7)	5940270	32	30	31	15	5	12	4	4	7	0	0.911	1.000	1.000
601	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(7), PRKCA(10), PTK2B(14)	5418338	34	30	34	12	12	11	5	2	4	0	0.550	1.000	1.000
602	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), LTB4R(5), P2RY1(4), P2RY2(3), P2RY6(2)	4799440	31	30	31	15	10	6	6	4	5	0	0.807	1.000	1.000
603	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(2), GRIA2(28), JUND(1), PPP1R1B(1)	2959877	35	29	35	15	4	14	10	0	7	0	0.836	1.000	1.000
604	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(2), ALAS2(6), CPOX(4), FECH(4), HMBS(5), PPOX(7), UROS(2)	6125365	31	29	31	20	1	10	11	3	6	0	0.997	1.000	1.000
605	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(5), B3GALT2(4), B3GALT5(3), B3GNT5(5), FUT1(4), FUT2(1), FUT3(5), ST3GAL3(4), ST3GAL4(4)	5787730	35	29	35	10	8	12	8	3	4	0	0.362	1.000	1.000
606	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(7), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4)	13355738	34	29	34	15	2	10	10	4	8	0	0.951	1.000	1.000
607	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(4), CASP8(6), FADD(2), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5)	6647115	34	29	34	10	4	10	12	4	4	0	0.525	1.000	1.000
608	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(17), SNAP25(5), STX1A(1)	2633838	28	27	28	10	4	9	5	3	7	0	0.692	1.000	1.000
609	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(10), EPHX2(3), HSD3B7(7), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	3845148	30	27	30	12	5	15	6	1	3	0	0.650	1.000	1.000
610	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(2), MDH1(3), ME1(3), PC(9), PDHA1(5), SLC25A11(3)	7432397	28	27	28	11	4	7	4	9	4	0	0.739	1.000	1.000
611	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(6), AOC3(11), CES1(8), ESD(2)	4884444	27	25	27	10	6	10	4	3	4	0	0.528	1.000	1.000
612	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(3), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(6)	4525222	25	25	25	18	2	5	10	1	7	0	0.996	1.000	1.000
613	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(2), CSF1(1), IL6(2), LDLR(10), LPL(8)	4286004	25	24	25	12	5	7	4	5	4	0	0.912	1.000	1.000
614	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(6), PSMB1(2), PSMB10(1), PSMB5(1), PSMB6(1)	7053300	25	22	25	7	4	10	6	3	2	0	0.508	1.000	1.000
615	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(1), IL1B(1), MST1(6), MST1R(7), TNF(2)	5164336	19	19	19	12	2	9	0	4	4	0	0.915	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	412157	1	1	1	2	0	0	0	1	0	0	0.987	1.000	1.000
