rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(5), NR1H3(5), NR1H4(3), RXRA(2)	3418440	15	15	15	0	2	2	4	3	4	0	0.0133	0.000407	0.250
2	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(2), FPGS(1), GCH1(1), SPR(2)	3429581	10	10	10	1	3	3	2	1	1	0	0.0914	0.0318	1.000
3	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(3), CREBBP(11), DFFB(1), GZMA(2), PRF1(1)	6668804	18	18	18	2	2	1	3	4	8	0	0.264	0.0351	1.000
4	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(2), GRIA2(6)	2208351	8	8	8	1	0	0	1	5	2	0	0.583	0.0362	1.000
5	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), HTR2C(6), PLCB1(6), TUB(1)	4745469	14	13	14	1	2	4	6	2	0	0	0.0632	0.0458	1.000
6	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREBBP(11), EP300(2), NCOA3(5), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RARA(1), RXRA(2)	13212238	30	29	30	2	2	2	7	8	11	0	0.0406	0.0522	1.000
7	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(4), GABRA2(3), GABRA3(2), GABRA4(4), GABRA5(2), PRKCE(1), SOD1(1)	4480716	17	16	17	3	3	0	4	6	4	0	0.280	0.0570	1.000
8	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(11), DAXX(3), PAX3(5), RARA(1), SP100(7), TNF(1), TNFRSF1A(2)	10230269	30	29	30	4	3	2	10	5	10	0	0.119	0.0584	1.000
9	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD3E(2), CD3G(1), CD8A(1), ICAM1(1), ITGAL(6), ITGB2(2), PTPRC(3)	6899991	19	18	19	2	3	5	7	2	2	0	0.0454	0.0588	1.000
10	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	781618	3	3	3	1	0	0	2	0	1	0	0.790	0.0611	1.000
11	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(1)	1384022	5	5	5	1	0	0	1	4	0	0	0.598	0.0641	1.000
12	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	IL8(3), SLPI(1)	1051627	4	4	4	0	0	1	1	1	1	0	0.348	0.0683	1.000
13	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(3), CSF1(1), LDLR(5), LPL(1)	3569081	10	9	10	1	1	3	4	1	1	0	0.183	0.0718	1.000
14	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR2(2), BDKRB2(4), KNG1(1), NOS3(2), REN(2)	5606147	13	13	13	1	5	2	2	4	0	0	0.0511	0.0736	1.000
15	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT1(1), FUT3(2), FUT6(1), ST3GAL3(3)	2630898	8	8	8	0	4	1	2	0	1	0	0.0388	0.0755	1.000
16	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT1(1), FUT3(2), ST3GAL3(3)	4630480	11	11	11	1	4	2	3	0	2	0	0.0981	0.0764	1.000
17	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(2), CD3G(1), HLA-A(1), ICAM1(1), ITGAL(6), ITGB2(2), PRF1(1)	5325651	16	14	15	2	2	3	4	4	3	0	0.106	0.0909	1.000
18	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(4), AASDHPPT(1), AASS(3), KARS(2)	4691233	10	10	10	1	0	0	3	5	2	0	0.254	0.107	1.000
19	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR6(4), NFS1(1), THTPA(1), TPK1(2)	4211866	10	9	10	1	3	2	0	3	2	0	0.183	0.116	1.000
20	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(3), HSD3B7(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1)	3099771	8	8	8	0	2	0	4	1	1	0	0.124	0.138	1.000
21	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(1), ESR2(2), PDE1A(1), PDE1B(1), PLCB1(6), PLCB2(3), TRH(1)	6966866	15	15	15	0	0	4	8	3	0	0	0.0162	0.140	1.000
22	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(4), XYLT2(1)	3814791	10	10	10	1	4	1	3	1	1	0	0.112	0.142	1.000
23	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), XYLT1(4), XYLT2(1)	3814791	10	10	10	1	4	1	3	1	1	0	0.112	0.142	1.000
24	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD3E(2), CD3G(1), ICAM1(1), ITGAL(6), ITGB2(2), PTPRC(3)	7319026	18	17	18	2	2	5	7	2	2	0	0.0619	0.146	1.000
25	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(1), B4GALT5(3), FUT8(1), ST3GAL2(2), ST3GAL3(3)	4992058	11	11	11	0	4	1	2	3	1	0	0.0606	0.156	1.000
26	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), HAO1(3), HAO2(2), HYI(1), MDH1(1), MDH2(2), MTHFD1(2), MTHFD1L(3), MTHFD2(1)	8551441	17	17	16	0	6	2	4	3	2	0	0.00573	0.165	1.000
27	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CDKN1B(1), CUL1(2), SKP2(2), TFDP1(3), UBE2M(1)	4386084	9	9	9	1	2	3	1	1	2	0	0.187	0.174	1.000
28	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2), GLUD1(1), GLUD2(3)	2738215	7	6	7	1	0	1	3	2	1	0	0.582	0.181	1.000
29	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(3), ACAT2(1), OXCT1(2)	2287159	6	5	6	1	0	2	2	2	0	0	0.489	0.193	1.000
30	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	11	DNM1(1), GABRA1(4), GABRA2(3), GABRA3(2), GABRA4(4), GABRA5(2), GPHN(2), SRC(1)	7298062	19	19	19	3	4	1	4	6	4	0	0.194	0.194	1.000
31	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PDXP(1), PSAT1(1)	3154268	7	7	7	1	0	1	2	3	1	0	0.472	0.201	1.000
32	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), HAO1(3), HAO2(2), HYI(1), MDH1(1), MDH2(2), MTHFD1(2), MTHFD1L(3), MTHFD2(1)	8973148	17	17	16	0	6	2	4	3	2	0	0.00546	0.220	1.000
33	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(3), KARS(2)	3203801	6	6	6	1	0	0	1	4	1	0	0.484	0.223	1.000
34	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3E(2), CD3G(1), CD8A(1), CSF3(1), IL8(3), KITLG(1)	4182671	13	12	13	3	1	3	5	1	3	0	0.390	0.224	1.000
35	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	5	DAG1(3), GNAQ(1), ITPKB(4)	3407204	8	7	8	1	2	2	3	0	1	0	0.264	0.225	1.000
36	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	GLB1(1), GUSB(2), HEXA(3), HEXB(1), IDS(2), LCT(9), NAGLU(2)	8723739	20	20	20	2	1	3	10	2	4	0	0.0847	0.228	1.000
37	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), ADRB2(1), CFTR(2), GNAS(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	7835961	15	15	14	1	4	0	3	3	5	0	0.109	0.231	1.000
38	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(2), RELA(1), TNFRSF11A(2), TNFSF11(1), TRAF6(2)	7266699	15	15	15	2	2	8	3	2	0	0	0.105	0.261	1.000
39	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F2R(3), F3(1), F5(8), F7(1), FGA(3), FGB(2), PROS1(1), SERPINC1(2)	10400442	25	24	25	3	4	3	11	6	1	0	0.112	0.270	1.000
40	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	6	CUL1(2), FBXW7(5), TFDP1(3)	4156772	10	10	10	2	3	1	3	1	2	0	0.450	0.279	1.000
41	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), FUT1(1), FUT9(1), HEXA(3), HEXB(1), ST3GAL2(2), ST8SIA1(3)	6595122	12	12	12	1	2	2	3	5	0	0	0.112	0.286	1.000
42	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL2(2), ST3GAL5(1), ST8SIA1(3)	3475188	7	7	7	0	1	1	2	2	1	0	0.166	0.288	1.000
43	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(5), HLA-DRA(1), HLA-DRB1(1), IL5RA(1)	3640692	8	7	8	1	2	1	2	2	1	0	0.357	0.302	1.000
44	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(2), NFKBIA(2), PLCB1(6), PRKCA(2), RELA(1)	5499775	14	12	14	2	2	3	5	1	3	0	0.283	0.314	1.000
45	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(2)	2724801	6	5	6	0	0	1	1	1	3	0	0.220	0.314	1.000
46	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(6), ERBB3(5), NRG1(4)	6936555	15	15	15	2	0	4	7	3	1	0	0.250	0.319	1.000
47	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT9(1), HEXA(3), HEXB(1), ST3GAL2(2), ST8SIA1(3)	6169646	11	11	11	1	2	1	3	5	0	0	0.168	0.321	1.000
48	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(2), GAD1(1), GAD2(2), GGT1(1)	3710398	7	7	7	1	1	2	0	2	2	0	0.339	0.324	1.000
49	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), B3GNT1(1), FUT1(1), FUT9(1), GCNT2(2), ST8SIA1(3)	3824717	9	9	9	2	2	2	1	2	2	0	0.365	0.331	1.000
50	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), UGDH(1), UXS1(2)	2655592	5	5	4	0	0	0	3	1	1	0	0.387	0.334	1.000
51	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	1212450	3	3	3	1	0	0	2	1	0	0	0.814	0.343	1.000
52	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(3), ACADS(1), ACAT1(3), HADHA(1)	3433184	8	7	8	2	1	2	2	1	2	0	0.589	0.346	1.000
53	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(2)	1775458	3	3	3	0	0	1	0	1	1	0	0.496	0.346	1.000
54	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(1), CREBBP(11), EP300(2), FADD(1), HDAC3(2), IKBKB(2), NFKB1(2), NFKBIA(2), RELA(1), TNF(1), TNFRSF1A(2), TRAF6(2)	14509449	29	28	29	3	3	5	6	5	10	0	0.0706	0.356	1.000
55	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATM(8), ATR(3), BRCA2(13), CHEK2(3), FANCA(5), FANCC(1), FANCD2(1), FANCE(1), FANCF(2), FANCG(1), HUS1(1), MRE11A(1), RAD17(1), RAD50(1), RAD51(1)	26304766	43	41	43	2	4	4	8	11	16	0	0.00750	0.369	1.000
56	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	27	ADRA1A(1), ADRB2(1), CHRM2(5), CHRM3(5), CHRM5(2), DRD1(2), DRD2(2), DRD3(1), HRH1(1), HRH2(1), HTR1A(4), HTR1E(3), HTR1F(3), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1)	14760973	49	45	49	8	10	5	22	11	1	0	0.0120	0.376	1.000
57	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(3), AOC2(4), AOC3(2)	3865151	9	9	9	2	1	0	1	3	4	0	0.619	0.385	1.000
58	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(1), APOBEC3A(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	4897834	8	8	8	0	3	3	2	0	0	0	0.0553	0.390	1.000
59	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(3), SPCS3(1)	2049575	4	4	4	0	0	1	2	1	0	0	0.333	0.415	1.000
60	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(4), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(2), PRKAR2B(1)	6728671	11	11	11	0	2	1	3	2	3	0	0.0408	0.416	1.000
61	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(3), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), DDC(2), EPX(2), GOT1(1), HPD(3), LPO(1), MAOA(2), MAOB(1), MPO(2), PRDX5(1), TAT(2), TPO(6)	14140460	35	33	35	4	4	3	11	10	7	0	0.0266	0.424	1.000
62	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(2), CD3G(1)	1884959	3	3	3	1	0	0	2	0	1	0	0.760	0.427	1.000
63	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), CAT(1), EPX(2), LPO(1), MPO(2), PRDX5(1), SHMT1(2), SHMT2(1), TPO(6)	7402507	18	18	18	3	4	1	7	4	2	0	0.147	0.437	1.000
64	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3)	2056105	3	3	3	0	1	0	1	1	0	0	0.471	0.443	1.000
65	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	20	CHUK(1), FADD(1), IKBKB(2), IRAK1(3), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), TLR4(5), TNF(1), TNFAIP3(3), TNFRSF1A(2), TRAF6(2)	15406136	31	28	31	3	5	9	7	7	3	0	0.0169	0.466	1.000
66	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(8), ATR(3), CHEK2(3)	10438589	14	14	14	0	3	1	3	4	3	0	0.0512	0.485	1.000
67	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(1), B3GNT2(2), B4GALT2(1), CHST2(2), FUT8(1), ST3GAL2(2), ST3GAL3(3)	7184220	12	12	12	1	5	2	2	2	1	0	0.103	0.489	1.000
68	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BNIP1(1), GOSR2(1), SNAP23(1), STX10(1), STX11(1), STX12(1), STX16(3), STX3(2), STX5(3), STX6(1), TSNARE1(2), VTI1A(1), VTI1B(1)	10370292	19	19	19	2	3	2	4	5	5	0	0.0626	0.504	1.000
69	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(2), NRG2(3), NRG3(1), PRKCA(2)	5956645	9	9	9	1	2	1	1	4	1	0	0.241	0.508	1.000
70	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP7(1), DFFB(1), HMGB1(1), TOP2A(8), TOP2B(1)	6200296	12	12	12	2	0	1	5	1	5	0	0.754	0.517	1.000
71	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), UGDH(1), UXS1(2)	3383213	5	5	4	0	0	0	3	1	1	0	0.392	0.517	1.000
72	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), DRD1(2), DRD2(2), GRM1(4), PLCB1(6), PPP2CA(2), PPP3CA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	10151605	24	22	24	4	2	2	12	5	3	0	0.198	0.547	1.000
73	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(3), IL8(3), NFKB1(2), RELA(1), SOD1(1), TNF(1), XDH(2)	6763675	15	15	15	3	1	3	8	1	2	0	0.426	0.550	1.000
74	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(3), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(6), ITGB2(2), PTPRC(3)	9774956	21	20	21	3	2	5	6	5	3	0	0.171	0.555	1.000
75	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT1(2), SHMT2(1)	2556703	4	4	4	0	1	1	0	2	0	0	0.265	0.579	1.000
76	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(2), LPO(1), MPO(2), SHMT1(2), SHMT2(1), TPO(6)	7412231	17	17	17	3	4	0	7	4	2	0	0.204	0.587	1.000
77	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST12(1), PAPSS1(1), SULT1A1(2), SULT1E1(1), SULT2A1(1), SULT2B1(1), SUOX(1)	5857165	9	9	9	1	2	0	2	4	1	0	0.268	0.591	1.000
78	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(1), HLA-DRB1(1)	1619865	2	2	2	0	0	1	0	0	1	0	0.574	0.600	1.000
79	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(2), KERA(1)	2424076	3	3	3	1	0	0	1	2	0	0	0.845	0.602	1.000
80	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), MIOX(1), UGDH(1)	5325654	10	10	10	2	0	4	1	3	2	0	0.429	0.602	1.000
81	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(5), MBTPS1(2), MBTPS2(1), SCAP(2), SREBF1(1), SREBF2(1)	6664447	12	12	12	2	3	1	4	3	1	0	0.310	0.606	1.000
82	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), EHHADH(2), HADHA(1), SDS(1)	3142413	6	6	6	2	0	0	4	1	1	0	0.846	0.608	1.000
83	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	APC(11), AXIN1(1), BTRC(1), CREBBP(11), CSNK1D(1), CSNK2A1(2), CTNNB1(2), FZD1(1), HDAC1(1), MAP3K7(2), NLK(1), PPARD(3), PPP2CA(2), TLE1(1), WIF1(2)	17673663	42	38	42	6	1	6	13	12	10	0	0.0798	0.610	1.000
84	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(1), B4GALT2(1), FUT1(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), ST3GAL6(1), ST8SIA1(3)	9022710	18	18	18	3	5	3	2	4	4	0	0.174	0.610	1.000
85	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CREBBP(11), GNAS(3), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PTPRC(3), ZAP70(1)	14225370	33	33	32	5	4	3	7	7	12	0	0.147	0.611	1.000
86	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CREBBP(11), GNAS(3), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PTPRC(3), ZAP70(1)	14225370	33	33	32	5	4	3	7	7	12	0	0.147	0.611	1.000
87	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1R(4), TNF(1)	3723027	6	6	6	1	1	1	3	0	1	0	0.522	0.614	1.000
88	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(3), PPP2CA(2), PRKAA2(2), PRKAB2(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	9419891	19	19	18	3	4	1	2	6	6	0	0.211	0.614	1.000
89	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT2(1), GALNT3(1), GALNT4(2), GALNT6(2), GALNT8(1), ST3GAL2(2), WBSCR17(1)	9501967	13	13	13	1	1	3	3	5	1	0	0.0966	0.621	1.000
90	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB4A(1), RAB9A(2)	2866716	4	4	4	1	2	1	1	0	0	0	0.561	0.627	1.000
91	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(1), FUCA2(1), GLB1(1), HEXA(3), HEXB(1), LCT(9), MANBA(1), NEU1(1), NEU2(1), NEU3(1)	10333449	20	20	20	3	2	4	8	3	3	0	0.125	0.632	1.000
92	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	14	B3GAT1(2), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(1), CHST12(1), CHST14(1), CHSY1(1), DSE(2), UST(2), XYLT1(4), XYLT2(1)	8195377	18	16	18	2	6	1	8	0	3	0	0.0906	0.633	1.000
93	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(11), EP300(2), LPL(1), NCOA1(2), NCOA2(2), RXRA(2)	12010963	20	20	20	3	0	2	3	7	8	0	0.332	0.633	1.000
94	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2B(2), ADORA3(2), P2RY1(1), P2RY2(2), P2RY6(1)	3685423	8	8	8	2	2	1	2	3	0	0	0.431	0.638	1.000
95	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(1), SULT1E1(1), SULT2A1(1), SUOX(1)	4107107	5	5	5	0	2	0	0	2	1	0	0.240	0.647	1.000
96	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(1), ALDOB(1), ALDOC(1)	2530664	3	3	3	1	2	1	0	0	0	0	0.647	0.651	1.000
97	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDKN1A(1), CDKN1B(1), E2F2(2), NXT1(1), PRB1(1)	4433274	6	6	6	1	2	2	0	2	0	0	0.373	0.655	1.000
98	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(3), ZAP70(1)	6078262	10	10	10	2	0	2	4	1	3	0	0.495	0.671	1.000
99	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(3), ACAT2(1), BDH1(1), HMGCS2(1), OXCT1(2)	4770368	8	7	8	2	0	2	3	2	1	0	0.526	0.681	1.000
100	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(2), PRKCA(2), PTK2B(3)	4505585	9	9	9	2	3	0	4	1	1	0	0.532	0.681	1.000
101	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2B5(7), EIF2S1(1), EIF2S2(1)	7464131	12	12	12	2	3	2	3	2	2	0	0.317	0.685	1.000
102	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), GLB1(1), HEXA(3), HEXB(1), LCT(9), ST3GAL2(2), ST3GAL5(1), ST6GALNAC3(2), ST8SIA1(3), ST8SIA5(1)	10701995	25	23	25	4	1	3	12	5	4	0	0.162	0.687	1.000
103	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BIRC3(2), CASP8(2), FADD(1), TNF(1), TNFRSF1A(2), TRAF2(1)	5141250	9	9	9	2	0	3	4	1	1	0	0.505	0.698	1.000
104	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(1), ESR1(1), GREB1(4), MTA1(2), MTA3(2), TUBA8(1)	5824861	11	11	11	2	2	3	5	1	0	0	0.236	0.700	1.000
105	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	15	GLB1(1), GUSB(2), HEXA(3), HEXB(1), HPSE(1), HPSE2(2), IDS(2), LCT(9), NAGLU(2)	11877945	23	22	23	3	1	4	11	3	4	0	0.110	0.702	1.000
106	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), NR3C1(2), RXRA(2), TNF(1)	3724079	6	6	6	2	0	1	2	2	1	0	0.724	0.713	1.000
107	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), WASL(1)	5354026	7	7	7	1	0	3	3	1	0	0	0.423	0.725	1.000
108	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(4), FARSB(1), GOT1(1), PAH(3), TAT(2), YARS(1), YARS2(1)	5887981	15	15	15	4	1	1	4	5	4	0	0.584	0.726	1.000
109	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(5), HLA-DRA(1), HLA-DRB1(1)	2015723	7	6	7	3	1	1	2	2	1	0	0.867	0.729	1.000
110	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), BHMT(2), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(3), MARS(3), MARS2(1), MTFMT(2), TAT(2)	13299128	21	21	21	2	1	5	9	6	0	0	0.0648	0.736	1.000
111	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), ADRB2(1), GNAS(3), PLCE1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	8814852	14	14	13	2	4	0	1	4	5	0	0.249	0.742	1.000
112	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(3), PRKACA(1)	3867796	7	7	6	2	3	0	1	1	2	0	0.596	0.749	1.000
113	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(1), FADS2(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1)	6609043	9	9	9	1	0	1	4	2	2	0	0.347	0.752	1.000
114	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), DHRS7(2), HSD3B7(1), PON3(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1)	5491530	9	9	9	2	1	2	4	0	2	0	0.425	0.762	1.000
115	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	1373509	1	1	1	1	0	0	0	1	0	0	0.950	0.778	1.000
116	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(1), FH(1), IDH1(1), MDH1(1), MDH2(2)	5992322	7	7	7	0	1	1	2	2	1	0	0.124	0.781	1.000
117	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(3), IL13(1), MAPK14(2), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	6596349	16	16	16	4	4	1	3	6	2	0	0.367	0.781	1.000
118	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP68(3), SRP72(2), SRPR(1)	4948922	8	8	8	2	0	2	4	0	2	0	0.767	0.782	1.000
119	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(2), CHUK(1), IKBKB(2), MAP3K1(2), MAP3K5(5), MAPK14(2), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(1), TNFRSF9(1), TRAF2(1)	12771617	22	21	22	3	4	7	2	5	4	0	0.111	0.787	1.000
120	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1), SHMT1(2), SHMT2(1)	3444430	4	4	4	1	1	1	0	2	0	0	0.612	0.789	1.000
121	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(2), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1)	11119784	19	19	19	3	1	5	6	3	4	0	0.129	0.792	1.000
122	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(2), CDKN1A(1), NEK1(4)	4779889	8	8	8	2	2	0	3	2	1	0	0.746	0.795	1.000
123	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(1), HK2(2), HK3(4), IMPA2(1), ISYNA1(1)	7200409	10	10	10	1	4	2	4	0	0	0	0.116	0.798	1.000
124	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2)	2484854	2	2	2	0	0	1	0	1	0	0	0.498	0.802	1.000
125	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(1), FUCA2(1), GLB1(1), HEXA(3), HEXB(1), LCT(9), MAN2B1(3), MAN2B2(2), MANBA(1), NEU1(1), NEU2(1), NEU3(1)	12684238	25	24	25	4	2	4	10	6	3	0	0.119	0.812	1.000
126	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	27	CSF1(1), CSF3(1), HLA-DRA(1), HLA-DRB1(1), IFNA1(2), IFNB1(1), IL10(2), IL13(1), IL8(3), LTA(1), TGFB2(1), TNF(1)	8607280	16	15	16	3	1	3	3	4	5	0	0.310	0.822	1.000
127	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD8A(1), CSF1(1), CSF3(1), IL8(3)	3985938	6	6	6	2	2	1	0	1	2	0	0.587	0.823	1.000
128	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(1), IL10(2), IL13(1), IL16(4), IL8(3), LTA(1), TNF(1)	6609887	15	14	15	4	1	2	4	5	3	0	0.569	0.824	1.000
129	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(1), CREBBP(11), DUSP1(1), EP300(2), IKBKB(2), IL8(3), MAP2K6(1), MAP3K14(1), MAP3K7(2), MAPK14(2), MYD88(1), NFKB1(2), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(3), TLR2(1), TNF(1)	19085636	40	36	40	5	5	7	9	10	9	0	0.0591	0.828	1.000
130	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), LRP8(1), RELN(10), VLDLR(1)	9489436	14	13	14	2	1	4	5	3	1	0	0.170	0.832	1.000
131	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	31	AKR1B1(3), B4GALT2(1), G6PC(1), G6PC2(1), GAA(1), GALE(1), GALK2(1), GALT(1), GCK(1), GLB1(1), HK1(1), HK2(2), HK3(4), HSD3B7(1), LCT(9), MGAM(6), PFKM(1), PFKP(2), RDH11(1), RDH12(1), RDH13(1), RDH14(1)	23401941	42	40	42	4	9	5	16	7	5	0	0.00450	0.837	1.000
132	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	16	ABL1(1), ATM(8), CDKN1A(1), CHEK2(3), MAPK8(1), MRE11A(1), NFKB1(2), NFKBIA(2), RAD50(1), RAD51(1), RELA(1)	16005114	22	21	22	2	5	3	5	2	7	0	0.104	0.837	1.000
133	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(2), CYP11A1(2), CYP11B2(4), CYP21A2(2), HSD3B1(2), HSD3B2(1)	5090938	13	13	12	4	2	0	5	3	3	0	0.830	0.840	1.000
134	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	10	AKR1C4(2), CYP11A1(2), CYP11B2(4), CYP21A2(2), HSD3B1(2), HSD3B2(1)	5090938	13	13	12	4	2	0	5	3	3	0	0.830	0.840	1.000
135	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(1), HK2(2), HK3(4)	6635587	8	8	8	1	4	2	2	0	0	0	0.168	0.851	1.000
136	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGA4(3), ITGAL(6), ITGB2(2), SELE(2)	7807291	14	13	14	3	2	3	5	3	1	0	0.342	0.852	1.000
137	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	7	CCNA1(2), CUL1(2), SKP2(2), TFDP1(3)	4296002	9	9	9	3	1	3	2	1	2	0	0.663	0.853	1.000
138	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(2), GAD1(1), HDC(2)	3422614	5	5	5	2	1	1	1	2	0	0	0.752	0.856	1.000
139	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(2), ATM(8), CDKN1A(1)	10119919	11	11	11	0	2	2	2	3	2	0	0.0548	0.856	1.000
140	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(1), EIF2S1(1), EIF2S2(1), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1)	5838716	10	9	10	2	1	2	3	2	2	0	0.549	0.859	1.000
141	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1), GLUD1(1)	3194870	3	3	3	1	0	0	2	1	0	0	0.863	0.860	1.000
142	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(1), COQ6(1)	2689343	2	2	2	1	0	0	1	0	1	0	0.886	0.867	1.000
143	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25A(1), CDC25B(2), MYT1(1)	9137482	12	12	12	2	1	1	5	2	3	0	0.522	0.868	1.000
144	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), FH(1), MDH1(1), OGDH(3), SDHA(1)	6227354	7	7	7	0	1	2	3	0	1	0	0.138	0.870	1.000
145	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	IDI2(1), SQLE(1)	2830969	2	2	2	1	0	0	0	2	0	0	0.890	0.870	1.000
146	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), LPO(1), MPO(2), TPO(6)	5373334	11	11	11	3	2	0	6	2	1	0	0.531	0.879	1.000
147	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	2087463	1	1	1	1	0	0	0	1	0	0	0.957	0.888	1.000
148	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2)	10171402	13	13	12	2	3	1	2	6	1	0	0.269	0.888	1.000
149	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2)	10171402	13	13	12	2	3	1	2	6	1	0	0.269	0.888	1.000
150	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2)	10171402	13	13	12	2	3	1	2	6	1	0	0.269	0.888	1.000
151	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), GART(3), MTFMT(2), MTHFD1(2), MTHFD1L(3), MTHFD2(1), SHMT1(2), SHMT2(1)	12276420	22	22	21	4	4	2	9	3	4	0	0.328	0.893	1.000
152	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(3), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2)	5812232	11	11	10	3	2	0	1	3	5	0	0.600	0.894	1.000
153	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(1), APAF1(2), CASP9(2), DAXX(3), TNF(1)	7242669	9	9	9	2	0	2	3	2	2	0	0.464	0.899	1.000
154	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1B(1), BMPR2(3)	4130282	6	6	6	2	0	1	2	3	0	0	0.667	0.901	1.000
155	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(6), CYP7A1(1), HMGCR(2), LDLR(5), LIPC(1), LPL(1), LRP1(12)	16439596	28	27	28	4	7	3	8	5	5	0	0.0404	0.903	1.000
156	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(2), CTH(1), DNMT1(2), DNMT3A(4), DNMT3B(3), MARS(3), MARS2(1)	11266428	16	16	16	2	1	4	6	5	0	0	0.155	0.903	1.000
157	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	15	ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), ALOX5AP(1), GGT1(1), LTA4H(1), PLA2G6(1), PTGDS(1), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2)	8803131	18	17	18	4	2	7	8	0	1	0	0.110	0.903	1.000
158	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADHA(1), HSD17B4(1), MECR(3), PPT1(1)	5613059	7	7	7	2	2	0	3	2	0	0	0.601	0.908	1.000
159	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(1), FURIN(1)	3115895	2	2	2	1	0	1	0	1	0	0	0.848	0.910	1.000
160	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACOX1(1), ACOX3(1), ELOVL2(2), ELOVL6(1), FADS2(2), HADHA(1), PECR(1)	7116002	9	9	9	2	2	1	2	2	2	0	0.487	0.910	1.000
161	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(1), ACO2(1), ACSS1(1), FH(1), IDH1(1), MDH1(1), MDH2(2)	8947929	10	10	10	0	1	1	4	3	1	0	0.0635	0.911	1.000
162	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(3), ACAT2(1), EHHADH(2), GCDH(1), HADHA(1), SDS(1)	5111812	9	7	9	3	0	3	4	1	1	0	0.743	0.913	1.000
163	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1)	2175891	1	1	1	2	0	0	0	0	1	0	0.972	0.913	1.000
164	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(1), GNPDA2(1), HEXA(3), HEXB(1), HK1(1), HK2(2), HK3(4), RENBP(2), UAP1(2)	10945056	18	16	18	3	4	2	5	5	2	0	0.215	0.916	1.000
165	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(5), ATM(8), CDKN1A(1), CPB2(1), CSNK1D(1), MAPK8(1), NFKBIB(1), NQO1(1)	12698426	19	19	19	3	3	2	7	3	4	0	0.272	0.918	1.000
166	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), SHMT1(2)	10602386	13	13	12	2	3	1	2	6	1	0	0.267	0.919	1.000
167	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), GART(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), SHMT1(2), SHMT2(1)	12030532	20	20	19	4	4	2	7	3	4	0	0.383	0.924	1.000
168	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ANKRD1(2), NR4A3(1), WDR1(2)	6888360	6	6	6	0	2	0	1	3	0	0	0.193	0.924	1.000
169	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(8), CDC25A(1), CDC25B(2), MYT1(1)	9994129	12	12	12	2	1	1	5	2	3	0	0.516	0.928	1.000
170	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(1), IFNA1(2), IFNB1(1), IKBKB(2), IRAK1(3), IRAK2(1), IRAK3(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(2), MAPK8(1), MYD88(1), NFKB1(2), NFKBIA(2), RELA(1), TGFB2(1), TNF(1), TRAF6(2)	18859339	31	29	31	4	6	9	7	7	2	0	0.0369	0.928	1.000
171	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1)	3811874	4	3	4	2	0	1	1	1	1	0	0.874	0.930	1.000
172	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(3), CD3E(2), CD3G(1), CXCR3(3), IL12RB1(1), IL12RB2(2), JAK2(1), STAT4(2), TYK2(2)	9414409	17	16	17	4	1	3	7	3	3	0	0.407	0.930	1.000
173	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	11	CNR1(1), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(1), PTGDR(1), PTGFR(3)	6419980	10	10	10	3	3	0	3	1	3	0	0.557	0.936	1.000
174	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), C9orf95(1), CD38(2), ENPP1(3), ENPP3(3), NADK(2), NADSYN1(2), NMNAT2(1), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2)	14233046	28	27	26	5	4	2	4	11	7	0	0.198	0.937	1.000
175	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(1), GGT1(1), MARS(3), MARS2(1), PAPSS1(1), SCLY(2)	7798658	9	8	9	0	1	2	2	3	1	0	0.0700	0.937	1.000
176	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	22	ALDOA(1), ALDOB(1), ALDOC(1), GOT1(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PGK1(1), PGK2(1), PKLR(1), RPIA(1), TKT(2), TKTL1(4), TKTL2(1)	12553609	21	21	21	4	4	4	8	4	1	0	0.196	0.939	1.000
177	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), CD38(2), ENPP1(3), ENPP3(3), NADSYN1(2), NMNAT2(1), NNMT(1), NNT(3), NT5E(2)	9749525	22	21	21	5	3	2	4	9	4	0	0.286	0.941	1.000
178	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(1), ALDOB(1), ALDOC(1), G6PD(5), GPI(2), PFKM(1), PFKP(2), PGD(1), PRPS1L1(2), RPIA(1), TKT(2), TKTL1(4), TKTL2(1)	14834811	24	21	24	3	4	8	9	3	0	0	0.0255	0.942	1.000
179	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(6), GLS(1), GLUD1(1), GOT1(1)	5007314	11	11	11	7	0	2	5	1	3	0	0.988	0.947	1.000
180	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(3), F2R(3), FGA(3), FGB(2), PLAU(2), PLG(4), SERPINB2(1), SERPINE1(2)	9012044	23	21	23	5	4	3	10	4	2	0	0.319	0.948	1.000
181	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(2), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1), XYLB(1)	16776104	31	30	31	5	3	5	11	6	6	0	0.120	0.949	1.000
182	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(1), IFNAR2(1), IFNB1(1), STAT1(2), STAT2(2), TYK2(2)	6934106	11	11	11	3	0	2	5	4	0	0	0.604	0.950	1.000
183	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	CSF3(1), FLT3(3), KITLG(1), TGFB2(1)	5457715	6	6	6	2	0	1	1	2	2	0	0.723	0.953	1.000
184	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(2), CTH(1), GOT1(1), LDHA(1), LDHB(1)	4377851	6	6	6	2	0	0	4	1	1	0	0.894	0.953	1.000
185	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), HLA-DRB1(1), IL12RB1(1), IL12RB2(2), IL18R1(2), IL2RA(1), IL4R(1)	8554209	9	9	9	2	0	4	2	1	2	0	0.410	0.953	1.000
186	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(2), CD3G(1), IL2RA(1), TGFB2(1), TGFBR1(1), TGFBR2(3), TGFBR3(4), TOB1(1), TOB2(1)	7093509	15	14	15	4	1	2	9	1	2	0	0.608	0.953	1.000
187	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(2), GOT1(1), PAH(3), TAT(2), YARS(1)	5672574	11	11	11	5	0	1	1	5	4	0	0.834	0.956	1.000
188	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(2), GLI2(10), GLI3(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), SUFU(1)	10257183	23	21	23	5	4	2	9	5	3	0	0.283	0.957	1.000
189	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(11), EP300(2), ESR1(1), PELP1(1), SRC(1)	9520544	16	15	16	4	0	1	5	4	6	0	0.680	0.960	1.000
190	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3)	4971096	3	3	3	0	1	0	2	0	0	0	0.526	0.962	1.000
191	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(2), CASP1(3), CASP8(2), CASP9(2), PRF1(1)	8541087	12	12	12	3	1	3	3	4	1	0	0.459	0.962	1.000
192	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CHUK(1), ELK1(2), FOS(1), IKBKB(2), IRAK1(3), LY96(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK14(2), MAPK8(1), MYD88(1), NFKB1(2), NFKBIA(2), PPARA(1), RELA(1), TIRAP(1), TLR2(1), TLR3(2), TLR4(5), TLR6(4), TLR7(2), TLR9(1), TRAF6(2)	23097995	46	41	46	7	7	11	14	11	3	0	0.0347	0.964	1.000
193	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	CPT1A(1), LEPR(5), PRKAA2(2), PRKAB2(1), PRKAG1(1), PRKAG2(1)	9799465	11	11	11	2	1	2	1	5	2	0	0.420	0.967	1.000
194	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1)	8706572	14	13	14	4	0	4	3	4	3	0	0.582	0.968	1.000
195	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN2(7), ACTN3(2), CTNNA1(3), CTNNB1(2), PTK2(2), PXN(2), SRC(1), VCL(6)	11684004	25	24	24	5	4	2	11	3	5	0	0.274	0.968	1.000
196	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FHL5(2), FSHB(1), FSHR(7), GNAS(3)	5904426	16	16	15	5	3	0	3	6	4	0	0.780	0.968	1.000
197	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(1), MPO(2), PRDX5(1), TPO(6), TYR(1)	6116412	13	13	13	4	2	1	6	3	1	0	0.583	0.969	1.000
198	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	18	CAMK2B(1), CAMK2D(2), DAG1(3), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), NFAT5(4), PDE6A(2), PDE6B(1), PDE6C(4), PDE6H(1), TF(2)	22405421	40	39	40	6	3	8	11	10	8	0	0.0960	0.972	1.000
199	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT2(1), G6PC(1), GAA(1), GALE(1), GALK2(1), GALT(1), GANAB(3), GCK(1), GLB1(1), HK1(1), HK2(2), HK3(4), LCT(9), MGAM(6), PFKM(1), PFKP(2)	20360478	39	37	39	6	8	5	14	7	5	0	0.0386	0.972	1.000
200	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CALM3(1), CCL4(1), CXCL12(1), FOS(1), GNAQ(1), MAPK14(2), MAPK8(1), PLCG1(2), PRKCA(2), PTK2B(3)	8795588	16	16	16	4	3	3	6	3	1	0	0.456	0.976	1.000
201	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNA2(1), CDKN1B(1), E2F2(2), E2F4(1), PRB1(1)	5337264	8	8	8	3	2	2	1	3	0	0	0.706	0.976	1.000
202	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CTH(1)	2995771	1	1	1	1	0	0	0	1	0	0	0.964	0.977	1.000
203	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(1), ALDOC(1), G6PD(5), GPI(2), PFKM(1), PFKP(2), PGD(1), PRPS1L1(2), RPIA(1), TKT(2)	13029358	19	16	19	3	4	6	6	3	0	0	0.0701	0.979	1.000
204	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACB(8), MCAT(2), OXSM(1)	8216433	11	11	11	3	2	3	4	1	1	0	0.523	0.980	1.000
205	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(1), TAT(2), TYR(1)	3169437	6	6	6	4	0	1	1	3	1	0	0.958	0.981	1.000
206	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(6), MAP3K1(2), MAPK14(2), NCOR2(3), RARA(1), RXRA(2)	9825549	16	15	16	4	2	2	4	4	4	0	0.593	0.982	1.000
207	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CAMKK1(1)	7311688	10	10	10	3	1	2	3	3	1	0	0.632	0.982	1.000
208	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	19	ATM(8), ATR(3), CDC25A(1), CDC25B(2), CDKN1A(1), CHEK2(3), EP300(2), MYT1(1), PRKDC(7), RPS6KA1(1)	24942345	29	29	29	3	4	3	7	9	6	0	0.0753	0.982	1.000
209	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(11), CDH1(2), CREBBP(11), EP300(2), MAP3K7(2), SKIL(2), TGFB2(1), TGFBR1(1), TGFBR2(3)	17165223	35	30	35	6	1	4	11	12	7	0	0.281	0.983	1.000
210	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(5), CALCRL(4), CD97(3), ELTD1(1), EMR1(1), EMR2(2), GHRHR(2), GIPR(1), LPHN1(1), LPHN2(4), LPHN3(6), SCTR(1), VIPR2(1)	17308538	34	33	34	6	5	1	10	14	4	0	0.130	0.984	1.000
211	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACPP(2), ENPP1(3), ENPP3(3), FLAD1(2), TYR(1)	6421904	13	13	12	4	3	0	4	3	3	0	0.712	0.984	1.000
212	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	22	GPAA1(1), GPLD1(2), PGAP1(7), PIGA(1), PIGF(1), PIGG(5), PIGH(1), PIGK(1), PIGN(1), PIGO(4), PIGT(1), PIGU(1), PIGV(1), PIGX(1), PIGZ(2)	15057540	30	30	29	7	4	5	5	10	6	0	0.359	0.986	1.000
213	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPOR(2), JAK2(1), NFKB1(2), NFKBIA(2), RELA(1)	7858336	9	8	9	2	2	2	1	1	3	0	0.609	0.987	1.000
214	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	ICAM1(1), ITGAL(6), ITGAM(1), ITGB2(2), SELE(2)	6778705	12	12	12	4	2	3	4	3	0	0	0.603	0.988	1.000
215	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	CASP6(2), CASP7(1), CASP8(2), DAXX(3), DFFB(1), FADD(1), LMNA(3), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(7), PTPN13(5), RIPK2(2), SPTAN1(4)	25826762	41	37	41	5	3	8	12	11	7	0	0.0488	0.988	1.000
216	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), OPRK1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	8198305	8	8	8	2	1	0	1	4	2	0	0.597	0.989	1.000
217	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), DUSP1(1), IKBKAP(1), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1), TNFAIP3(3), TRAF3(1), TRAF6(2)	11874078	19	18	19	4	5	3	3	6	2	0	0.348	0.990	1.000
218	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), PRMT2(2), PRMT5(2), PRMT8(2)	8839986	9	8	9	2	3	1	3	2	0	0	0.375	0.990	1.000
219	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(3), CTH(1), GGT1(1), MARS(3), MARS2(1), PAPSS1(1), PRMT2(2), PRMT5(2), PRMT8(2), SCLY(2)	15517466	18	16	18	2	4	3	5	5	1	0	0.0641	0.990	1.000
220	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), EP300(2), LDHA(1), NOS3(2)	10522035	8	8	8	1	0	0	3	4	1	0	0.437	0.991	1.000
221	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(2)	3310977	2	2	2	3	1	0	0	0	1	0	0.954	0.991	1.000
222	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(1), ATM(8), ATR(3), CCNA1(2), CDC25A(1), CDKN1A(1), CDKN1B(1), HDAC1(1), SKP2(2), TFDP1(3), TGFB2(1)	18018675	24	24	24	4	2	5	7	5	5	0	0.237	0.992	1.000
223	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(2), GRB2(2), PRKCA(2), SRC(1)	6053182	8	8	8	3	1	0	5	0	2	0	0.789	0.992	1.000
224	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), CRY1(2), CSNK1E(1), PER1(3)	5217697	8	8	8	4	0	1	2	3	2	0	0.898	0.992	1.000
225	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(2), L1CAM(8), LYN(2), SELP(3)	10470710	21	19	21	5	6	3	5	4	3	0	0.300	0.992	1.000
226	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C5(3), C6(4), C7(3), ICAM1(1), IL8(3), ITGA4(3), ITGAL(6), ITGB2(2), SELP(3), TNF(1), VCAM1(1)	15915864	31	27	31	7	3	6	6	9	7	0	0.174	0.992	1.000
227	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), DHRS2(1), DHRS7(2), PRMT2(2), PRMT5(2), PRMT8(2)	8951446	12	11	12	3	3	3	3	2	1	0	0.306	0.993	1.000
228	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(2), CTH(1), GOT1(1), LDHA(1), LDHB(1), SDS(1), SULT1B1(1), SULT1C2(1), SULT1C4(1)	8094555	10	10	10	3	0	0	6	2	2	0	0.861	0.993	1.000
229	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(8), BMPR1B(1), CDKN1B(1), EGR1(2), ESR2(2), FSHR(7), INHA(1), LHCGR(4), MLH1(2), MSH5(3), NCOR1(1), NRIP1(2), PGR(1), PRLR(2), VDR(1), ZP2(3)	22683099	41	38	41	6	3	4	13	14	7	0	0.106	0.994	1.000
230	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BIRC3(2), CASP8(2), FADD(1), MAP2K4(2), MAP3K3(1), MAP3K7(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), TNF(1), TNFAIP3(3), TNFRSF1A(2), TRAF2(1)	16551553	24	23	24	4	1	5	10	4	4	0	0.220	0.994	1.000
231	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(3), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), DDC(2), EPX(2), GOT1(1), HPD(3), LPO(1), MAOA(2), MAOB(1), MPO(2), MYST3(5), MYST4(6), SH3GLB1(1), TAT(2), TPO(6)	22370833	46	43	46	8	4	4	16	14	8	0	0.115	0.994	1.000
232	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(3), AGXT2(3), ALAS1(1), ALAS2(1), AOC2(4), AOC3(2), BHMT(2), CHDH(1), CHKA(1), CPT1B(5), CTH(1), DMGDH(2), GARS(1), GATM(1), GLDC(3), MAOA(2), MAOB(1), PLCB2(3), PLCG1(2), PLCG2(1), PSPH(1), SARDH(2), SARS(1), SHMT1(2), SHMT2(1), TARS(2)	26238345	49	46	49	8	6	3	16	15	9	0	0.131	0.995	1.000
233	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	35	ATF2(2), GCK(1), MAP2K4(2), MAP3K1(2), MAP3K10(3), MAP3K12(2), MAP3K13(3), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAP3K5(5), MAP3K7(2), MAP3K9(1), MAPK7(2), MAPK8(1), MAPK9(1), MYEF2(1), PAPPA(4), SHC1(1), TRAF6(2)	31353859	41	39	41	4	7	9	16	5	4	0	0.0101	0.995	1.000
234	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), LCT(9), MPI(1), PYGM(3)	8881174	14	14	14	4	1	1	9	1	2	0	0.455	0.996	1.000
235	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR3(5), CXCR3(3), IL12RB1(1), IL12RB2(2), IL18R1(2), IL4R(1), TGFB2(1)	12931869	16	16	16	4	2	4	5	3	2	0	0.325	0.996	1.000
236	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD2(3), POLE(2), POLG(2), POLQ(3)	10843497	12	12	12	3	0	3	6	2	1	0	0.548	0.996	1.000
237	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA5(2), ANXA6(1), CYP11A1(2), EDNRA(2), EDNRB(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGFR(3), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2)	13516147	23	23	22	5	7	2	8	3	3	0	0.297	0.997	1.000
238	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	20	ALDOA(1), ALDOB(1), ALDOC(1), GOT1(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PGK1(1), PKLR(1), RPIA(1), TKT(2)	11167890	15	15	15	4	4	2	4	4	1	0	0.460	0.997	1.000
239	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(6), GNA12(1), GNAQ(1), MYL2(1), MYLK(6), PLCB1(6), PPP1R12B(3), PRKCA(2)	13676138	28	27	28	6	3	4	11	8	2	0	0.269	0.997	1.000
240	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(2), SDHA(1), SDHC(1)	4312974	5	5	5	3	0	2	1	1	1	0	0.914	0.997	1.000
241	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMB1(1), PSMB4(2), PSMB6(1), PSMC3(4), PSMD14(1), RPN1(2), RPN2(2)	8717545	13	12	13	5	1	0	5	3	4	0	0.871	0.998	1.000
242	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP6(2), ACPP(2), ENPP1(3), ENPP3(3), FLAD1(2), MTMR1(2), MTMR6(4), TYR(1)	9921955	21	20	20	6	5	1	4	6	5	0	0.634	0.998	1.000
243	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(1), GPI(2), HK1(1), PGK1(1), PKLR(1)	4921782	6	6	6	3	1	0	3	2	0	0	0.816	0.998	1.000
244	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(3), CYP11A1(2), CYP11B2(4), HSD3B1(2), HSD3B2(1)	4560528	12	12	12	6	1	1	6	3	1	0	0.938	0.998	1.000
245	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	13	ADSL(1), ADSS(1), MTHFD2(1), POLB(2), POLG(2), RRM1(1)	7582726	8	8	8	3	1	3	2	1	1	0	0.749	0.998	1.000
246	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(1)	5178261	4	4	4	3	0	0	2	1	1	0	0.970	0.999	1.000
247	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(3), ACAT2(1), EHHADH(2), HADHA(1), SDS(1)	5501843	9	7	9	5	0	2	5	1	1	0	0.944	0.999	1.000
248	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(3), ACADS(1), ACADVL(2), ACSL1(2), ACSL3(2), ACSL4(2), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), PECR(1), SLC25A20(1)	11016623	19	19	19	5	2	4	5	4	4	0	0.472	0.999	1.000
249	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR2B(4), POLR2C(1), POLR2H(1)	7591190	6	6	6	2	1	0	1	3	1	0	0.717	0.999	1.000
250	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), PTPRU(1), STAT1(2), STAT2(2), TYK2(2)	8020279	9	9	9	3	0	1	5	3	0	0	0.742	0.999	1.000
251	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(2), CHUK(1), GH1(1), NFKB1(2), NFKBIA(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), RELA(1)	9261511	17	16	17	7	1	2	6	3	5	0	0.897	0.999	1.000
252	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2B(2), GTF2E1(1), HDAC3(2), NCOA1(2), NCOA2(2), NCOA3(5), NCOR2(3), RARA(1), RXRA(2), TBP(1)	15110766	22	22	22	7	1	3	4	4	10	0	0.729	0.999	1.000
253	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25B(2), MNAT1(1)	5772182	5	5	5	3	0	0	4	0	1	0	0.972	0.999	1.000
254	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(1), MAP3K14(1), MAPK14(2), MAPK8(1), NFKB1(2), RELA(1), TRAF2(1), TRAF3(1), TRAF5(1), TRAF6(2)	9244702	13	13	13	4	3	4	3	3	0	0	0.561	0.999	1.000
255	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C5(3), C6(4), C7(3), C8A(1), C9(1)	8153687	13	12	13	5	2	1	3	4	3	0	0.743	0.999	1.000
256	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(1), MMP9(1), RECK(3)	4885712	5	5	5	6	1	0	2	1	1	0	0.984	0.999	1.000
257	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	25	CASP8(2), DFFB(1), FADD(1), LMNA(3), MADD(6), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(7), SPTAN1(4), TNF(1), TNFRSF1A(2), TRAF2(1)	23757536	38	36	38	6	5	10	9	7	7	0	0.0889	0.999	1.000
258	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	DBH(2), DDC(2), GAD1(1), GAD2(2), HDC(2), MAOA(2), PAH(3), SLC18A3(1)	8687479	15	15	15	9	1	1	4	5	4	0	0.938	0.999	1.000
259	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	14	NDUFB2(1), NDUFB5(1), NDUFS1(1), NDUFV1(1)	4413522	4	4	4	2	0	0	1	3	0	0	0.849	0.999	1.000
260	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2)	5207103	8	8	8	4	0	4	1	2	1	0	0.815	0.999	1.000
261	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2)	5207103	8	8	8	4	0	4	1	2	1	0	0.815	0.999	1.000
262	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(1), ALOX15(2), ALOX5(2), CYP4F2(2), EPX(2), GGT1(1), LPO(1), LTA4H(1), MPO(2), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PRDX5(1), PTGDS(1), PTGES2(1), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2), TPO(6)	17435981	34	32	34	7	5	6	17	4	2	0	0.0857	0.999	1.000
263	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(2), DPYD(2), DPYS(1), ENPP1(3), ENPP3(3), PANK3(1), PANK4(2), UPB1(2)	8528619	16	16	15	6	3	1	4	5	3	0	0.735	0.999	1.000
264	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(2), COASY(2), DPYD(2), DPYS(1), ENPP1(3), ENPP3(3), ILVBL(1), PANK3(1), PANK4(2), UPB1(2), VNN1(2)	10761365	21	21	20	8	3	1	6	6	5	0	0.803	0.999	1.000
265	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(2), E2F4(1), ETS1(1), ETS2(1), FOS(1), HDAC5(1), NCOR2(3), RBL1(1), RBL2(3), SIN3A(1), SIN3B(3)	15139956	19	17	19	4	4	2	8	2	3	0	0.276	0.999	1.000
266	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(2), BRAF(2), CREB3(1), SRC(1)	7518188	6	6	6	4	0	1	2	1	2	0	0.975	0.999	1.000
267	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	9	FOS(1), MAPK14(2), MAPK8(1), PRKCA(2)	5321336	6	6	6	5	2	1	0	2	1	0	0.972	0.999	1.000
268	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(2), G6PD(5), GCLM(1), GGT1(1), GPX6(3), GSR(2), GSS(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM4(1), GSTO2(1), IDH1(1), MGST2(1), TXNDC12(2)	13090401	27	25	27	7	0	8	11	6	2	0	0.347	0.999	1.000
269	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	CASP8(2), FADD(1), MAP2K4(2), MAP3K1(2), MAPK8(1), NFKB1(2), NSMAF(1), RELA(1), TNFRSF1A(2), TRAF2(1)	13077015	15	15	15	4	2	5	4	2	2	0	0.411	0.999	1.000
270	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CSNK1D(1), PPP2CA(2)	5646578	3	3	3	3	0	0	2	0	1	0	0.960	0.999	1.000
271	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	17	ACY1(1), ARG1(1), ARG2(1), ASL(1), CPS1(6), GATM(1), GLUD1(1), ODC1(2), OTC(1)	10389159	15	15	15	9	1	2	4	4	4	0	0.983	0.999	1.000
272	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(2), CYP2A6(1), CYP2A7(2), NAT2(2), XDH(2)	5357788	11	11	11	5	1	3	4	2	1	0	0.688	1.000	1.000
273	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	NRF1(1), UBE2D3(1), UBE2M(1)	6228191	3	3	3	2	2	0	0	1	0	0	0.867	1.000	1.000
274	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), MDH1(1), ME1(2), PC(1)	5831001	6	6	6	5	1	0	4	0	1	0	0.983	1.000	1.000
275	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(2), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AKR1C4(2), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(1), HSD3B7(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1), SLC27A5(1), SOAT2(2), SRD5A1(1), SRD5A2(1)	20574948	35	32	35	8	4	7	11	7	6	0	0.263	1.000	1.000
276	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	26	AGA(1), FUCA2(1), GLB1(1), GUSB(2), HEXA(3), HEXB(1), HPSE(1), HPSE2(2), IDS(2), LCT(9), MAN2B1(3), MAN2B2(2), MANBA(1), NAGLU(2), NEU1(1), NEU2(1), NEU3(1)	20255050	34	32	34	7	3	7	13	7	4	0	0.161	1.000	1.000
277	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(3), AGXT2(3), ALAS1(1), ALAS2(1), AOC2(4), AOC3(2), BHMT(2), CHDH(1), CHKA(1), CTH(1), DMGDH(2), GARS(1), GATM(1), GLDC(3), HSD3B7(1), MAOA(2), MAOB(1), PSAT1(1), PSPH(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1), SARDH(2), SARS(1), SARS2(1), SDS(1), SHMT1(2), SHMT2(1), TARS(2), TARS2(1)	27292608	47	42	47	8	6	2	16	12	11	0	0.170	1.000	1.000
278	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(7), MAP2(10), PPP2CA(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(2), PRKAR2B(1), PRKCE(1)	12011070	26	24	26	9	2	1	11	7	5	0	0.857	1.000	1.000
279	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR109B(1), GPR34(3), GPR45(1), GPR75(1)	6420492	8	8	8	4	3	1	4	0	0	0	0.689	1.000	1.000
280	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGFR(6), HGS(2), TF(2), TFRC(3)	8447216	16	15	16	5	2	1	9	3	1	0	0.737	1.000	1.000
281	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(11), EP300(2), IL7R(4), JAK3(4), LCK(1), PIK3CA(3), PIK3R1(2), PTK2B(3), STAT5B(3)	17945678	33	33	33	8	1	3	11	10	8	0	0.530	1.000	1.000
282	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(2), ACE2(2), AGTR2(2), ANPEP(2), CPA3(1), CTSA(2), CTSG(2), ENPEP(1), LNPEP(2), MAS1(1), MME(5), REN(2)	13236112	24	23	24	7	3	5	8	6	2	0	0.556	1.000	1.000
283	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), EHHADH(2), HADHA(1), SDS(1)	7884200	12	12	12	6	0	4	4	2	2	0	0.901	1.000	1.000
284	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(2), EPOR(2), FOS(1), GRB2(2), JAK2(1), MAPK8(1), PLCG1(2), SHC1(1), SOS1(4), STAT5B(3)	13808389	21	20	21	5	1	4	11	4	1	0	0.431	1.000	1.000
285	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(1), HMGCR(2), MVK(1), NQO1(1), NQO2(1), SQLE(1)	6538725	7	7	7	4	1	2	1	2	1	0	0.868	1.000	1.000
286	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP51A1(1), DHCR24(1), DHCR7(1), EBP(2), GGCX(1), HMGCR(2), IDI2(1), MVK(1), NQO1(1), SQLE(1), TM7SF2(1)	11931449	13	13	13	4	3	4	2	2	2	0	0.544	1.000	1.000
287	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(2), CYP11B2(4), HSD17B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(1), SRD5A2(1), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1)	17286733	30	30	30	8	4	4	10	7	5	0	0.373	1.000	1.000
288	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), PAK1(1), PDGFRA(2), PIK3CA(3), PIK3R1(2), WASL(1)	8890020	14	14	14	8	0	4	4	4	2	0	0.972	1.000	1.000
289	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	CAT(1), GH1(1), IGF1R(1), PIK3CA(3), PIK3R1(2), SHC1(1), SOD1(1)	8413207	10	10	10	6	1	2	4	1	2	0	0.926	1.000	1.000
290	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP2(1), ACP6(2), ACPP(2), ALPI(2), ALPL(2), ALPP(2), CYP3A43(1), DHRS2(1), DHRS7(2), PON3(1)	10921862	17	17	17	8	2	5	4	2	4	0	0.834	1.000	1.000
291	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	27	ATG12(1), ATG3(3), ATG7(1), BECN1(1), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), PIK3C3(2), PIK3R4(4), PRKAA2(2)	12445317	21	21	21	5	0	2	10	8	1	0	0.609	1.000	1.000
292	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), CALM2(1), CALM3(1), GNAS(3), NFKB1(2), NOS3(2), NPPA(1), NR3C1(2), PIK3CA(3), PIK3R1(2), RELA(1)	10723321	19	19	18	9	1	2	6	6	4	0	0.955	1.000	1.000
293	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10(2), STAT1(2), STAT3(1), TNF(1)	7976177	6	6	6	4	0	1	3	0	2	0	0.935	1.000	1.000
294	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(3), ARHGEF1(6), F2(3), F2R(3), GNA12(1), GNAQ(1), MAP3K7(2), PIK3CA(3), PIK3R1(2), PLCB1(6), PPP1R12B(3), PRKCA(2), PTK2B(3)	16500483	38	34	38	9	8	8	14	6	2	0	0.256	1.000	1.000
295	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(3), PIK3R1(2), PLCB1(6), PLCG1(2), PRKCA(2), VAV1(3)	8539672	18	17	18	7	2	2	8	4	2	0	0.869	1.000	1.000
296	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C2(2), C3(1), C5(3), C6(4), C7(3), C8A(1), C9(1)	11536846	15	14	15	5	2	1	3	5	4	0	0.609	1.000	1.000
297	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), DUSP1(1), IKBKAP(1), IKBKB(2), LTA(1), MAP3K1(2), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1), TNFAIP3(3), TRAF1(3), TRAF2(1), TRAF3(1)	14562200	22	21	22	5	5	3	4	7	3	0	0.409	1.000	1.000
298	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(2), IL4R(1), IRS1(3), JAK3(4), SHC1(1), STAT6(4)	9314094	15	14	15	7	2	3	4	3	3	0	0.783	1.000	1.000
299	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB1(1), PSMB4(2), PSMB6(1), PSMC3(4), PSMD1(2), PSMD13(1)	10619306	11	10	11	5	0	0	6	2	3	0	0.904	1.000	1.000
300	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(2), CD3G(1), CXCR3(3), ETV5(1), IL12RB1(1), IL12RB2(2), IL18R1(2), JAK2(1), MAP2K6(1), MAPK14(2), MAPK8(1), STAT4(2), TYK2(2)	12041248	21	21	21	6	2	4	6	6	3	0	0.538	1.000	1.000
301	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(3), CD5(1), IFNA1(2), IFNB1(1), IL10(2), IL13(1), ITGAX(2), TLR2(1), TLR4(5), TLR7(2), TLR9(1)	12179855	23	21	23	7	0	7	6	8	2	0	0.517	1.000	1.000
302	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(1), DHCR7(1), HMGCR(2), MVK(1), SQLE(1)	7953803	6	6	6	3	1	3	1	1	0	0	0.750	1.000	1.000
303	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(1), JAK3(4), STAT3(1), TYK2(2)	7350053	8	8	8	5	1	1	2	3	1	0	0.913	1.000	1.000
304	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CSF1(1), IL6R(1), TGFB2(1), TNF(1), TNFRSF1A(2), TNFRSF8(2), TNFSF8(1)	8595650	11	11	11	5	3	3	2	1	2	0	0.698	1.000	1.000
305	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CCNH(1), CDC25A(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), RBL1(1), TFDP1(3)	9004235	12	12	12	7	2	3	4	1	2	0	0.937	1.000	1.000
306	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(3), IKBKB(2), JAK2(1), LIN7A(2), NFKB1(2), NFKBIA(2), RELA(1), TNF(1), TNFRSF1A(2), USH1C(2)	9985186	18	17	18	5	3	4	4	3	4	0	0.456	1.000	1.000
307	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	ICAM1(1), ITGA4(3), ITGAL(6), ITGAM(1), ITGB2(2), SELE(2), SELP(3)	10394595	18	17	18	6	2	3	6	5	2	0	0.680	1.000	1.000
308	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(3), ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), AOX1(5), DBH(2), DCT(3), DDC(2), GOT1(1), HPD(3), MAOA(2), MAOB(1), TAT(2), TPO(6), TYR(1)	19826165	44	40	44	10	4	5	13	15	7	0	0.245	1.000	1.000
309	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(1), KLRC1(1), KLRC2(1), KLRC3(1), PAK1(1), PIK3CA(3), PIK3R1(2), PTK2B(3), VAV1(3)	12196205	18	17	17	9	0	1	7	6	4	0	0.978	1.000	1.000
310	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), G6PD(5), GCLM(1), GGT1(1), GSS(3), GSTA1(1), GSTA2(1), GSTA4(1), GSTM4(1), GSTO2(1), IDH1(1), MGST2(1), PGD(1)	11724732	20	18	20	6	0	7	9	4	0	0	0.456	1.000	1.000
311	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), CALM3(1), DLG4(1), GRIN2A(4), GRIN2B(6), GRIN2C(1), GRIN2D(3), NOS1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2)	15872801	29	27	28	8	7	3	6	7	6	0	0.420	1.000	1.000
312	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(3), AGTR2(2), EDNRA(2), EDNRB(1), EGFR(6), FOS(1), NFKB1(2), PLCG1(2), PRKCA(2), RELA(1)	13698062	22	21	21	6	8	3	7	2	2	0	0.356	1.000	1.000
313	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), IL2RA(1), IL2RB(1), JAK3(4), LCK(1), MAPK8(1), SHC1(1), SOS1(4), STAT5B(3)	14976386	23	22	23	6	1	5	12	4	1	0	0.364	1.000	1.000
314	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(3), GALNT1(3), GALNT12(1), GALNT13(3), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(1), GALNT6(2), GALNT8(1), GALNTL2(1), GALNTL5(1), GCNT3(2), GCNT4(4), OGT(3), ST3GAL2(2), ST6GALNAC1(1), WBSCR17(1)	21363374	33	31	33	7	5	4	11	9	4	0	0.309	1.000	1.000
315	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ABP1(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), ASPA(1), CARM1(3), DDC(2), HAL(1), HDC(2), HNMT(1), MAOA(2), MAOB(1), PRMT2(2), PRMT5(2), PRMT8(2), UROC1(3)	24979906	39	38	39	8	6	5	9	13	6	0	0.161	1.000	1.000
316	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(2), CASP1(3), CASP7(1), CASP8(2), GAPDH(1), INSR(5), MAGI1(1), MAGI2(4), RERE(1), WWP2(1)	15107549	21	21	21	5	3	3	8	6	1	0	0.473	1.000	1.000
317	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	65	RPL10A(1), RPL10L(1), RPL14(1), RPL22L1(1), RPL23A(1), RPL30(1), RPL32(1), RPL8(1), RPS10(2), RPS3(1), RPS6(1), RPS9(1)	12778792	13	12	13	7	2	2	3	1	5	0	0.923	1.000	1.000
318	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), BDKRB2(4), CALM2(1), CALM3(1), CHRNA1(1), FLT1(3), FLT4(1), KDR(7), NOS3(2), PDE2A(4), PDE3A(3), PDE3B(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKG1(3), RYR2(22)	25072161	60	53	60	12	6	7	22	18	7	0	0.123	1.000	1.000
319	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT2(1), B4GALT5(3), DPAGT1(1), DPM1(1), FUT8(1), MAN1A1(2), MGAT1(1), MGAT3(1), MGAT4A(1), MGAT5(3), RPN1(2), RPN2(2)	12202466	19	19	19	6	2	1	8	4	4	0	0.704	1.000	1.000
320	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(2), CYP1A2(2), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2J2(1), CYP3A43(1), HSD3B7(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1)	15701400	27	26	27	7	2	2	16	5	2	0	0.444	1.000	1.000
321	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(3), AOC2(4), AOC3(2), CES7(4), DDHD1(1), MYST3(5), MYST4(6), PLA1A(1), SH3GLB1(1)	16726024	27	27	27	7	1	3	8	8	7	0	0.600	1.000	1.000
322	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(2), BIK(1), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), DFFB(1)	8789303	13	13	13	6	0	3	5	4	1	0	0.882	1.000	1.000
323	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(2), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), FADD(1), MAP2K4(2), MAP3K1(2), MAP3K14(1), NFKB1(2), NFKBIA(2), PARP1(3), PRF1(1), RELA(1), TNF(1), TNFRSF1A(2), TNFSF10(1), TRAF1(3), TRAF2(1)	23343051	34	31	34	7	4	7	9	7	7	0	0.203	1.000	1.000
324	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	21	APC(11), CREB3(1), DAG1(3), EPHB2(2), FOS(1), GNAQ(1), ITPKB(4), MAP2K4(2), MAPK8(1), MAPK8IP1(1), MAPK9(1)	15729958	28	24	28	8	3	4	10	8	3	0	0.598	1.000	1.000
325	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(1), APC(11), AXIN1(1), BTRC(1), CTNNB1(2), FZD1(1)	10268171	17	16	17	5	0	3	6	6	2	0	0.664	1.000	1.000
326	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), DHRS7(2), MYST3(5), MYST4(6), SH3GLB1(1)	10588810	15	15	15	5	0	4	5	4	2	0	0.712	1.000	1.000
327	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(3), CAP1(1), GNAS(3), MYT1(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RPS6KA1(1), SRC(1)	12310310	17	17	16	6	4	0	4	5	4	0	0.716	1.000	1.000
328	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOC2(4), AOC3(2), ASPA(1), DDC(2), HAL(1), HDC(2), HNMT(1), MAOA(2), MAOB(1)	16164688	27	27	27	8	2	4	6	9	6	0	0.544	1.000	1.000
329	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK2(1), JAK3(4), PTPRU(1)	8853351	6	6	6	3	1	1	1	2	1	0	0.731	1.000	1.000
330	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), FOS(1), NFKB1(2), NFKBIA(2), PLCB1(6), PRKCA(2), RELA(1), TNF(1)	10120162	16	14	16	6	2	4	5	2	3	0	0.735	1.000	1.000
331	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C2(2), C3(1), C5(3), C6(4), C7(3), C8A(1), C8B(2), C9(1), MASP1(3)	13768503	20	19	20	8	3	1	7	5	4	0	0.780	1.000	1.000
332	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(3), PER2(1), PER3(2)	10506543	15	14	14	7	0	2	4	7	2	0	0.876	1.000	1.000
333	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C2(2), C3(1), C5(3), C6(4), C7(3), C8A(1), C9(1), MASP1(3), MASP2(3), MBL2(1)	13924905	22	21	22	8	3	2	6	7	4	0	0.684	1.000	1.000
334	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), DHRS2(1), DHRS7(2), MYST3(5), MYST4(6), SH3GLB1(1)	16198796	24	23	24	7	0	6	8	5	5	0	0.604	1.000	1.000
335	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(2), ABCB4(6), ABCC1(3), ABCC3(1)	9652853	17	16	17	7	5	0	5	6	1	0	0.756	1.000	1.000
336	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(3), CSF2RB(2), IGF1R(1), KIT(8), KITLG(1), PIK3CA(3), PIK3R1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	13445036	26	26	26	9	7	3	6	6	4	0	0.628	1.000	1.000
337	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(1), DLST(1), FH(1), IDH1(1), IDH3A(1), MDH1(1), MDH2(2), PC(1), SDHA(1)	13394634	11	11	11	7	1	1	2	3	4	0	0.964	1.000	1.000
338	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	GAL3ST1(1), GLB1(1), LCT(9), NEU1(1), NEU2(1), NEU3(1), PPAP2A(2), SPTLC1(2)	14710990	18	18	18	6	2	3	7	2	4	0	0.593	1.000	1.000
339	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), BTRC(1), CDC16(2), CDC20(4), CDC23(1), CDC27(5), CUL1(2), CUL2(2), CUL3(1), FBXW11(1), FBXW7(5), SKP2(2), SMURF1(2), TCEB1(1), UBA1(3), UBE2D3(1), WWP2(1)	25670859	38	34	38	8	8	4	14	3	9	0	0.438	1.000	1.000
340	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), HDAC5(1), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(1)	12756510	16	16	16	5	1	3	6	5	1	0	0.667	1.000	1.000
341	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	57	ABO(1), B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GNT1(1), B3GNT2(2), B3GNT4(1), B3GNT5(1), B4GALNT1(1), B4GALT2(1), FUT1(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), PIGA(1), PIGF(1), PIGG(5), PIGH(1), PIGK(1), PIGN(1), PIGO(4), PIGT(1), PIGU(1), PIGV(1), PIGX(1), PIGZ(2), ST3GAL2(2), ST3GAL3(3), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(2), ST8SIA1(3), ST8SIA5(1)	29365280	53	49	53	11	11	11	11	10	10	0	0.0977	1.000	1.000
342	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6R(1), JAK2(1), JAK3(4), PTPRU(1), SRC(1), STAT3(1)	9781756	9	9	9	5	2	1	3	2	1	0	0.829	1.000	1.000
343	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(2), BIRC3(2), CASP1(3), CASP4(1), CASP6(2), CASP7(1), CASP8(2), CASP9(2), DFFB(1), LMNA(3), PRF1(1)	12222684	20	20	20	6	2	2	7	7	2	0	0.638	1.000	1.000
344	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(2), ATM(8), CASP6(2), CASP7(1), CASP9(2), EIF2S1(1), PRKCA(2), PTK2(2), PXN(2), STAT1(2)	17711570	24	24	24	6	3	2	8	5	6	0	0.560	1.000	1.000
345	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(2), IARS2(3), ILVBL(1), LARS(1), LARS2(2), VARS(3), VARS2(3)	12248895	15	15	15	6	3	1	6	3	2	0	0.845	1.000	1.000
346	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CMAS(1), CYB5R1(1), GFPT2(1), GNPDA2(1), HEXA(3), HEXB(1), HK1(1), HK2(2), HK3(4), MTMR1(2), MTMR6(4), NANS(1), RENBP(2), UAP1(2)	18431673	26	23	26	7	6	3	5	7	5	0	0.477	1.000	1.000
347	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(1), PIK3CA(3), PIK3R1(2), POLR1A(2)	10621413	8	8	8	8	1	1	3	2	1	0	0.992	1.000	1.000
348	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC3(2), CASP7(1), CASP8(2), CASP9(2), DFFB(1), PRF1(1), SCAP(2), SREBF1(1), SREBF2(1)	10978578	15	15	15	5	1	2	6	5	1	0	0.705	1.000	1.000
349	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CSF1R(2), EGFR(6), GRB2(2), MET(4), PDGFRA(2), PRKCA(2), SH3GLB1(1), SH3KBP1(1), SRC(1)	13026267	21	20	21	7	1	3	8	6	3	0	0.651	1.000	1.000
350	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(3), ACY1(1), ADC(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AMD1(1), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(6), GATM(1), MAOA(2), MAOB(1), ODC1(2), OTC(1)	19135728	39	36	39	10	2	6	10	11	10	0	0.494	1.000	1.000
351	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10(1), ALG10B(4), ALG11(2), ALG2(3), ALG8(2), ALG9(1), B4GALT2(1), DAD1(2), DHDDS(1), DPAGT1(1), DPM1(1), FUT8(1), GANAB(3), MAN1A1(2), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT3(1), MGAT4A(1), MGAT5(3), MGAT5B(2), RFT1(1), RPN1(2), RPN2(2), STT3B(3)	26798649	47	44	47	10	5	6	16	10	10	0	0.241	1.000	1.000
352	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CALM3(1), CHUK(1), EGR2(2), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(3), NFKB1(2), NFKBIA(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RELA(1), VIPR2(1)	17313791	28	27	28	8	6	3	7	8	4	0	0.529	1.000	1.000
353	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	EGFR(6), IGF1R(1), PPP2CA(2), PRKCA(2), TEP1(9), TERF1(1), TERT(1), TNKS(1)	16480620	23	23	23	7	6	2	7	3	5	0	0.431	1.000	1.000
354	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	JAK2(1), JAK3(4), STAT1(2), STAT3(1), STAT5B(3), TYK2(2)	11427841	13	13	13	5	1	1	7	3	1	0	0.759	1.000	1.000
355	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(2), CHUK(1), IKBKB(2), LTA(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAPK14(2), MAPK8(1), NFKB1(2), NFKBIA(2), RELA(1), TNF(1), TNFRSF1A(2), TRAF2(1)	15084558	24	23	24	7	4	5	6	5	4	0	0.593	1.000	1.000
356	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(3), G6PC(1), GAA(1), GANAB(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), GYS2(3), HK1(1), HK2(2), HK3(4), MGAM(6), PYGB(2), PYGM(3), SI(10), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1), UXS1(2)	36688445	70	64	68	14	11	8	22	17	12	0	0.0747	1.000	1.000
357	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	ATF1(2), CREB3(1), DUSP1(1), EEF2K(1), ELK1(2), MAP2K4(2), MAP2K6(1), MAP3K10(3), MAP3K4(2), MAP3K5(5), MAP3K7(2), MAPK14(2), MAPKAPK5(1), MKNK1(2), MYEF2(1), NFKB1(2), SRF(1), TRAF6(2)	21118761	33	32	33	9	5	5	11	6	6	0	0.531	1.000	1.000
358	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CD8A(1), CD8B(1), CIITA(1), CTSL1(4), HLA-A(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-G(3), HSP90AA1(2), HSPA5(3), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), KIR2DL1(1), KIR2DL3(3), KIR2DL4(2), KIR3DL1(3), KIR3DL2(1), KIR3DL3(2), KLRC1(1), KLRC2(1), KLRC3(1), LTA(1), NFYC(1), PDIA3(1), PSME1(2), PSME2(1), RFX5(1), RFXANK(1), RFXAP(1), TAPBP(3)	30036423	57	52	56	13	6	10	17	15	9	0	0.219	1.000	1.000
359	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADM(3), ACADS(1), ACADSB(1), ACADVL(2), ACAT1(3), ACAT2(1), ACOX1(1), ACOX3(1), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A11(6), CYP4A22(2), EHHADH(2), GCDH(1), HADHA(1), HSD17B4(1)	31863790	58	53	57	13	3	16	17	13	9	0	0.137	1.000	1.000
360	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(1), F13B(1), F2(3), F5(8), F7(1), F8(6), F9(1), FGA(3), FGB(2), LPA(7), PLAU(2), PLG(4), SERPINB2(1), SERPINE1(2), VWF(6)	22697544	49	47	49	12	9	4	20	10	6	0	0.335	1.000	1.000
361	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(3), ACAT2(1), ACOT11(1), DHRS2(1), DHRS7(2), EHHADH(2), GCDH(1), HADHA(1), MYST3(5), MYST4(6), SH3GLB1(1), YOD1(3)	16702996	27	23	27	8	0	7	12	5	3	0	0.602	1.000	1.000
362	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), KLK2(1), MAPK8(1), NGFR(2), PIK3CA(3), PIK3R1(2), PLCG1(2), SHC1(1), SOS1(4)	12262525	23	21	23	9	1	5	12	4	1	0	0.837	1.000	1.000
363	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CALM2(1), CALM3(1), EP300(2), HDAC1(1), MEF2D(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CC(1), PRKCA(2)	15135935	16	15	16	6	4	1	4	4	3	0	0.720	1.000	1.000
364	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(1), BCHE(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3)	15432777	19	18	19	8	1	3	8	4	3	0	0.823	1.000	1.000
365	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	79	ANPEP(2), CD19(2), CD1A(1), CD1B(2), CD1C(3), CD1D(1), CD2(3), CD22(3), CD34(1), CD36(2), CD37(1), CD38(2), CD3E(2), CD3G(1), CD5(1), CD55(1), CD8A(1), CD8B(1), CD9(1), CR1(3), CR2(2), CSF1(1), CSF1R(2), CSF3(1), CSF3R(2), DNTT(2), EPOR(2), FCGR1A(2), FLT3(3), HLA-DRA(1), HLA-DRB1(1), IL11RA(1), IL1R2(1), IL2RA(1), IL4R(1), IL5RA(1), IL6R(1), IL7R(4), ITGA1(2), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGAM(1), KIT(8), KITLG(1), MME(5), MS4A1(2), TFRC(3), THPO(1), TNF(1), TPO(6)	52150033	113	91	113	22	17	15	38	31	12	0	0.0183	1.000	1.000
366	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2B(2), GTF2E1(1), GTF2F2(1), GTF2H4(1), GTF2I(1), GTF2IRD1(2), TAF1(7), TAF12(1), TAF1L(2), TAF2(2), TAF4(2), TAF5(1), TAF5L(1), TAF6(1), TAF6L(3), TBPL2(2)	23513212	30	29	30	7	4	7	9	7	3	0	0.304	1.000	1.000
367	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(3), ALDOA(1), ALDOB(1), ALDOC(1), FPGT(2), HK1(1), HK2(2), HK3(4), HSD3B7(1), MPI(1), MTMR1(2), MTMR6(4), PFKFB1(1), PFKFB2(1), PFKFB3(1), PFKM(1), PFKP(2), PGM2(1), PMM2(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1)	22699576	35	33	35	9	9	6	12	4	4	0	0.272	1.000	1.000
368	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(2), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHUK(1), DFFB(1), FADD(1), GAS2(1), LMNA(3), MAP3K14(1), NFKB1(2), NFKBIA(2), RELA(1), SPTAN1(4), TNFRSF10A(2), TNFSF10(1), TRAF2(1)	21391941	32	30	32	8	5	5	11	7	4	0	0.476	1.000	1.000
369	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(3), F2R(3), ITGA1(2), PLA2G4A(1), PLCB1(6), PRKCA(2), PTGS1(3), PTK2(2), SRC(1), TBXAS1(2)	15977925	25	22	25	8	6	5	9	2	3	0	0.507	1.000	1.000
370	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPS(1), ENPP2(2), PAFAH2(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLD1(2), PLD2(2), PPAP2A(2)	15043860	16	16	16	8	1	4	6	3	2	0	0.916	1.000	1.000
371	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AP2A1(2), BTK(2), EEA1(3), GRASP(1), GSK3A(1), LYN(2), PDPK1(1), PFKM(1), PFKP(2), PLCG1(2), PRKCE(1), PRKCZ(2), VAV2(4)	14777817	24	23	24	8	4	2	12	5	1	0	0.613	1.000	1.000
372	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CALM3(1), CDKN1A(1), GNAQ(1), NFATC1(1), NFATC2(3), NFATC4(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKCA(2)	12909534	16	16	16	7	5	2	5	3	1	0	0.783	1.000	1.000
373	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN2(7), ACTN3(2), ITGA1(2), PTK2(2), PXN(2), SPTAN1(4), SRC(1)	18528783	21	21	20	7	5	1	10	1	4	0	0.706	1.000	1.000
374	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	58	ATP12A(3), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1F(1), ATP7B(2), COX10(1), COX6B1(1), NDUFB2(1), NDUFB5(1), NDUFS1(1), NDUFV1(1), PPA2(1), SDHA(1), SHMT1(2), UQCRB(1)	23574219	27	27	26	7	5	1	6	10	5	0	0.511	1.000	1.000
375	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(1), CBX3(1), CLOCK(1), CRY1(2), EIF4G2(3), ETV6(1), GFRA1(3), HSPA8(1), KLF9(1), NCKAP1(3), NR1D2(1), PER1(3), PER2(1), PIGF(1), TOB1(1), TUBB3(3), UCP3(1)	23025295	28	27	28	9	1	2	9	10	6	0	0.826	1.000	1.000
376	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACADM(3), ACOX1(1), ACOX3(1), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(1), ANGPTL4(1), CD36(2), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A11(6), CYP4A22(2), CYP7A1(1), CYP8B1(2), EHHADH(2), FABP2(1), FABP3(2), FABP4(1), FABP7(1), FADS2(2), GK2(2), HMGCS2(1), LPL(1), ME1(2), MMP1(2), NR1H3(5), OLR1(1), PCK2(1), PDPK1(1), PPARA(1), PPARD(3), RXRA(2), RXRB(2), RXRG(1), SLC27A2(2), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(1), UBC(2), UCP1(1)	42382630	82	78	81	17	10	15	27	19	11	0	0.0459	1.000	1.000
377	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(4), FOS(1), GRB2(2), JAK2(1), MAP2K4(2), MAP3K1(2), MAPK8(1), PIK3CA(3), PIK3R1(2), SOS1(4), STAT1(2), STAT5B(3)	17557537	27	25	27	9	1	3	15	5	3	0	0.756	1.000	1.000
378	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(1), EXTL3(2), GLCE(1), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), NDST2(3), NDST4(2)	13127569	15	15	15	6	2	2	5	5	1	0	0.765	1.000	1.000
379	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(1), EPRS(1), GUSB(2), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2B4(1), UROD(1), UROS(1)	17838652	21	20	21	7	1	5	6	6	3	0	0.596	1.000	1.000
380	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	APC(11), AXIN1(1), CTNNB1(2), FZD1(1), GJA1(2), IRAK1(3), LBP(1), LEF1(1), LY96(1), MYD88(1), NFKB1(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), RELA(1), TIRAP(1), TLR4(5)	18195852	41	37	41	11	3	8	17	8	5	0	0.490	1.000	1.000
381	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(2), COL4A3(1), COL4A4(7), COL4A5(7), COL4A6(5), F10(1), F11(1), F2(3), F2R(3), F5(8), F8(6), F9(1), FGA(3), FGB(2), KLKB1(1), PROS1(1), SERPINC1(2)	28906582	59	55	59	14	7	11	21	13	7	0	0.297	1.000	1.000
382	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(2), BIN1(3), CALM2(1), CALM3(1), DNM1(1), PICALM(3), PPP3CA(1), PPP3CC(1), SYNJ1(6)	14205144	21	21	21	8	3	6	5	6	1	0	0.723	1.000	1.000
383	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	49	ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP2J2(1), CYP4A11(6), CYP4A22(2), CYP4F2(2), DHRS4(1), EPHX2(3), GGT1(1), GPX6(3), LTA4H(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PTGDS(1), PTGES2(1), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(2)	24374917	50	47	49	12	4	10	25	8	3	0	0.117	1.000	1.000
384	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	29	ADCY3(2), ADRBK2(2), ARRB2(1), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CLCA1(2), CLCA2(2), CLCA4(4), CNGA3(6), GNAL(2), GUCA1B(1), PDE1C(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKG1(3)	19663467	37	35	37	10	6	3	18	8	2	0	0.396	1.000	1.000
385	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	DEGS2(1), ENPP7(1), GAL3ST1(1), GLB1(1), LCT(9), NEU1(1), NEU2(1), NEU3(1), PPAP2A(2), SGPP1(1), SPTLC1(2)	20730075	21	21	21	7	3	4	8	2	4	0	0.512	1.000	1.000
386	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(4), AASDHPPT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), BBOX1(1), DLST(1), EHHADH(2), EHMT2(2), GCDH(1), HADHA(1), PLOD1(2), PLOD2(1), PLOD3(2), SDS(1), SHMT1(2), SHMT2(1), TMLHE(1)	22796413	38	33	38	10	5	8	10	11	4	0	0.305	1.000	1.000
387	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLAT(1), DLST(1), FH(1), IDH3A(1), MDH1(1), MDH2(2), OGDH(3), PC(1), PDHX(1), PDK1(1), PDK3(2), SDHA(1), SDHC(1)	18443361	18	17	18	9	2	2	7	4	3	0	0.914	1.000	1.000
388	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(1), ACO2(1), DLST(1), FH(1), IDH1(1), IDH3A(1), MDH1(1), MDH2(2), OGDH(3), PC(1), PCK2(1), SDHA(1), SDHC(1)	19615762	18	18	18	8	2	2	6	4	4	0	0.874	1.000	1.000
389	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGTR2(2), COL4A1(5), COL4A2(2), COL4A3(1), COL4A4(7), COL4A5(7), COL4A6(5), REN(2)	16591394	33	32	33	10	4	6	9	9	5	0	0.443	1.000	1.000
390	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3A(1), POLR3B(1)	15427653	10	10	10	7	2	1	2	4	1	0	0.951	1.000	1.000
391	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(1), CDC7(1), DIAPH2(5), GMNN(1), MCM10(3), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), NACA(3), ORC1L(2), ORC2L(2), POLA2(1), POLD2(3), POLD3(1), POLE(2), POLE2(2), RFC1(2), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA4(2), RPS27A(1), UBA52(1), UBC(2)	31977481	48	46	48	10	7	6	16	13	6	0	0.209	1.000	1.000
392	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(3), APC(11), ATF2(2), AXIN1(1), BMP10(2), BMP2(1), BMP4(1), BMP5(1), BMPR2(3), CHRD(2), CTNNB1(2), FZD1(1), MAP3K7(2), MEF2C(1), MYL2(1), NPPA(1), NPPB(3), RFC1(2), TGFB2(1), TGFBR1(1), TGFBR2(3), TGFBR3(4)	22554773	49	41	49	12	3	7	24	11	4	0	0.402	1.000	1.000
393	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(2), FOS(1), GRB2(2), JAK2(1), MPL(1), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RASA1(2), SHC1(1), SOS1(4), STAT1(2), STAT3(1), STAT5B(3), THPO(1)	19577385	30	29	30	9	3	3	16	6	2	0	0.686	1.000	1.000
394	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	ANKRD6(2), APC(11), AXIN1(1), AXIN2(2), CTNNB1(2), DACT1(3), DKK1(1), DKK2(3), GSK3A(1), LRP1(12), MVP(3), SENP2(1), TSHB(1), WIF1(2)	24907004	45	42	45	11	10	4	14	11	6	0	0.272	1.000	1.000
395	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	53	ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AGK(2), AKR1A1(2), AKR1B1(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), CEL(1), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), DGKI(4), GK2(2), GLB1(1), GPAM(2), LCT(9), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2A(2)	36924006	61	54	61	14	5	13	25	12	6	0	0.152	1.000	1.000
396	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(1), BMP4(1), BMP5(1), BMP6(1), BTRC(1), CSNK1A1L(1), CSNK1D(1), CSNK1E(1), FBXW11(1), GLI1(6), GLI2(10), GLI3(2), HHIP(2), LRP2(14), PRKACA(1), PRKACB(1), PRKACG(1), PTCH1(6), PTCH2(1), RAB23(1), STK36(3), SUFU(1), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3), WNT8A(1), WNT9A(1), WNT9B(1)	37132573	76	65	75	17	13	13	30	14	6	0	0.113	1.000	1.000
397	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(1), ALDOB(1), ALDOC(1), FPGT(2), GCK(1), HK1(1), HK2(2), HK3(4), MPI(1), PFKFB1(1), PFKFB3(1), PFKM(1), PFKP(2), PMM2(1)	15417085	23	22	23	8	7	5	7	2	2	0	0.504	1.000	1.000
398	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(11), AXIN1(1), CREBBP(11), CTNNB1(2), EP300(2), FZD1(1), HDAC1(1), LEF1(1), PITX2(1), TRRAP(6)	20779097	37	33	37	10	0	5	13	10	9	0	0.603	1.000	1.000
399	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGFR(6), GRB2(2), PTPRB(2), RASA1(2), SHC1(1), SOS1(4), SPRY1(2), SPRY2(1), SPRY4(1), SRC(1)	16100307	22	22	22	8	2	3	14	2	1	0	0.843	1.000	1.000
400	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	30	ADC(3), CAD(6), CPS1(6), EPRS(1), GAD1(1), GAD2(2), GCLM(1), GFPT2(1), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(1), GMPS(3), GOT1(1), GSR(2), GSS(3), NADSYN1(2), PPAT(2), QARS(2)	25639188	44	39	44	11	4	4	17	10	9	0	0.476	1.000	1.000
401	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	37	ADAM17(1), APH1A(1), CREBBP(11), CTBP2(2), DTX1(1), DTX2(3), DTX3L(4), DTX4(2), DVL3(1), EP300(2), HDAC1(1), HES1(1), JAG1(1), MAML1(1), MAML2(2), MAML3(1), NCOR2(3), NOTCH2(5), NOTCH3(3), NOTCH4(9), NUMB(2), NUMBL(2), PSEN2(2), PSENEN(1), PTCRA(2), RBPJL(2), SNW1(1)	36659652	67	63	67	16	12	8	20	15	12	0	0.210	1.000	1.000
402	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(2), ALPL(2), ALPP(2), ASCC3(5), ATP13A2(2), DDX18(2), DDX23(1), DDX4(3), DDX52(1), DDX54(3), DDX55(1), ENTPD7(1), EP400(3), ERCC2(1), ERCC3(1), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(1), NUDT5(1), PTS(1), QDPR(1), RAD54L(4), RUVBL2(2), SETX(2), SKIV2L2(1), SMARCA2(3), SPR(2)	39333860	53	49	52	10	7	9	20	12	5	0	0.124	1.000	1.000
403	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(2), DARS(2), EPRS(1), FARS2(2), GARS(1), KARS(2), LARS(1), LARS2(2), MARS(3), MARS2(1), QARS(2), RARS(1), SARS(1), TARS(2), WARS(2), WARS2(1), YARS(1)	21653052	28	27	28	9	2	4	13	7	2	0	0.678	1.000	1.000
404	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	93	CASP8(2), CCL4(1), CD40(1), CD80(2), CHUK(1), CXCL9(1), FADD(1), FOS(1), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(2), IL8(3), IRAK1(3), IRAK4(2), IRF3(2), IRF5(3), LBP(1), LY96(1), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAPK14(2), MAPK8(1), MAPK9(1), MYD88(1), NFKB1(2), NFKBIA(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), RELA(1), SPP1(1), STAT1(2), TBK1(1), TIRAP(1), TLR1(3), TLR2(1), TLR3(2), TLR4(5), TLR5(3), TLR6(4), TLR7(2), TLR8(4), TLR9(1), TNF(1), TRAF3(1), TRAF6(2)	55379008	106	90	105	22	8	23	31	32	12	0	0.0540	1.000	1.000
405	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	CHUK(1), DAXX(3), EGFR(6), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(5), MAPK14(2), MAPK8(1), NFKB1(2), NFKBIA(2), PPP2CA(2), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), RELA(1), TNF(1), TNFRSF1A(2), TRAF2(1)	31424034	48	46	48	12	7	9	11	8	13	0	0.279	1.000	1.000
406	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(2), CARM1(3), CYP11B2(4), HSD17B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), PRMT2(2), PRMT5(2), PRMT8(2), SRD5A1(1), SRD5A2(1), STS(2), SULT1E1(1), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1)	30970175	51	47	51	13	9	5	18	12	7	0	0.292	1.000	1.000
407	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), CYP2C19(4), CYP2C9(1), DHRS2(1), DHRS7(2), EHHADH(2), HADHA(1), MYST3(5), MYST4(6), SH3GLB1(1), YOD1(3)	20009101	35	33	35	10	0	7	13	11	4	0	0.585	1.000	1.000
408	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	43	ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), CEL(1), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), GLB1(1), LCT(9), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(1), PNLIPRP2(1), PPAP2A(2)	29990871	49	44	49	14	3	12	19	10	5	0	0.374	1.000	1.000
409	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	62	APAF1(2), BIRC3(2), CASP1(3), CASP4(1), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHUK(1), DFFB(1), FADD(1), IKBKB(2), IRF2(3), IRF3(2), IRF5(3), IRF6(4), LTA(1), MAP2K4(2), MAP3K1(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF21(1), TNFSF10(1), TRAF1(3), TRAF2(1), TRAF3(1)	34754594	55	48	54	13	6	9	16	12	12	0	0.290	1.000	1.000
410	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(2), ATM(8), ATR(3), BAI1(2), CASP8(2), CASP9(2), CCNB3(4), CCNG2(1), CD82(1), CDKN1A(1), CHEK2(3), DDB2(1), EI24(1), GADD45B(1), GTSE1(1), MDM4(1), PERP(1), PTEN(5), RCHY1(1), RFWD2(1), RRM2B(2), SERPINB5(2), SERPINE1(2), SESN1(1), STEAP3(1), THBS1(3), TSC2(3), ZMAT3(2)	38845295	58	50	58	13	10	8	17	15	8	0	0.240	1.000	1.000
411	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), BBOX1(1), DLST(1), EHHADH(2), EHMT2(2), GCDH(1), HADHA(1), HSD17B4(1), HSD3B7(1), NSD1(5), OGDH(3), PLOD1(2), PLOD2(1), PLOD3(2), RDH11(1), RDH12(1), RDH13(1), RDH14(1), SETD1A(6), SETD7(1), SETDB1(3), SHMT1(2), SHMT2(1), SPCS3(1), SUV39H2(1), TMLHE(1)	36854283	59	52	59	14	7	8	21	17	6	0	0.255	1.000	1.000
412	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(2), DAXX(3), DDIT3(2), ELK1(2), GRB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(5), MAP3K7(2), MAP3K9(1), MAPK14(2), MAPKAPK5(1), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(2), PLA2G4A(1), RPS6KA5(2), SHC1(1), STAT1(2), TGFB2(1), TGFBR1(1), TRAF2(1)	23875560	41	41	41	11	2	9	17	6	7	0	0.472	1.000	1.000
413	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(3), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), ALDH1A3(1), ALDH3A1(2), AOC2(4), AOC3(2), AOX1(5), CARM1(3), DBH(2), DCT(3), DDC(2), ECH1(1), GOT1(1), HPD(3), MAOA(2), MAOB(1), MYST3(5), MYST4(6), PRMT2(2), PRMT5(2), PRMT8(2), SH3GLB1(1), TAT(2), TPO(6), TYR(1), TYRP1(1)	37653964	69	60	69	17	8	8	22	22	9	0	0.249	1.000	1.000
414	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	63	AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(4), BRS3(2), C3AR1(1), CCKBR(2), CCR3(5), CCR6(1), CCR8(2), CXCR3(3), EDNRA(2), EDNRB(1), FPR1(1), FSHR(7), GALT(1), GHSR(2), GNRHR(1), GPR77(1), GRPR(2), LHCGR(4), MC2R(4), MC3R(3), MC5R(1), NPY5R(2), OPRD1(1), OPRK1(1), PPYR1(1), SSTR1(1), TACR1(1), TACR3(2), TRHR(1), TSHR(4)	31384270	74	62	73	23	15	5	22	23	9	0	0.421	1.000	1.000
415	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	48	ACTG1(1), APAF1(2), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHUK(1), DAXX(3), DFFB(1), FADD(1), GSN(3), LMNA(3), MAP3K1(2), MAP3K14(1), MAP3K5(5), MAPK8(1), NFKB1(2), NFKBIA(2), NUMA1(3), PAK2(2), PRKDC(7), PSEN2(2), PTK2(2), RASA1(2), RELA(1), SPTAN1(4), TNF(1), TNFRSF1A(2), TRAF1(3), TRAF2(1)	43012842	67	56	67	14	5	17	15	16	14	0	0.147	1.000	1.000
416	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(2), CARS(2), DARS(2), EPRS(1), FARS2(2), FARSA(4), FARSB(1), GARS(1), IARS2(3), KARS(2), LARS(1), LARS2(2), MARS(3), MARS2(1), MTFMT(2), NARS2(2), PARS2(1), QARS(2), RARS(1), RARS2(3), SARS(1), SARS2(1), TARS(2), TARS2(1), VARS(3), VARS2(3), WARS(2), WARS2(1), YARS(1), YARS2(1)	36179757	55	50	55	12	8	6	25	11	5	0	0.228	1.000	1.000
417	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	53	ALG2(3), BFAR(2), BTK(2), CAD(6), CASP8(2), CASP8AP2(1), DAXX(3), EGFR(6), EPHB2(2), FADD(1), IL8(3), MAP2K4(2), MAP3K1(2), MAP3K5(5), MAPK8(1), MAPK8IP1(1), MAPK9(1), MET(4), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PTPN13(5), TPX2(1), TRAF2(1), TUFM(1)	43640883	66	60	66	15	6	15	20	14	11	0	0.172	1.000	1.000
418	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), FLNC(4), FSCN3(3), LIMK1(1), MYH2(9), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), ROCK2(2), VASP(1), WASL(1)	28255269	42	38	42	12	5	5	12	13	7	0	0.336	1.000	1.000
419	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	186	ACTB(1), ACTG1(1), ACTN2(7), ACTN3(2), ACTN4(1), ARHGAP5(2), BIRC3(2), BRAF(2), CHAD(1), COL11A1(9), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL3A1(5), COL4A1(5), COL4A2(2), COL4A4(7), COL4A6(5), COL5A1(3), COL5A2(4), COL5A3(10), COL6A3(13), COL6A6(7), COMP(2), CTNNB1(2), DIAPH1(1), DOCK1(1), EGFR(6), ELK1(2), ERBB2(5), FIGF(1), FLNB(5), FLNC(4), FLT1(3), FN1(5), GRB2(2), GRLF1(5), HGF(2), IGF1R(1), ITGA1(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAV(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), KDR(7), LAMA1(12), LAMA2(13), LAMA3(12), LAMA4(2), LAMB1(8), LAMB2(5), LAMB3(1), LAMB4(5), LAMC1(7), LAMC2(2), LAMC3(5), MAPK8(1), MAPK9(1), MET(4), MYL2(1), MYL7(1), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDGFC(1), PDGFD(1), PDGFRA(2), PDGFRB(3), PDPK1(1), PGF(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PPP1CB(1), PPP1R12A(2), PRKCA(2), PRKCG(2), PTEN(5), PTK2(2), PXN(2), RAPGEF1(3), RELN(10), RHOA(3), ROCK2(2), SHC1(1), SHC4(2), SOS1(4), SOS2(1), SPP1(1), SRC(1), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TLN2(5), TNC(4), TNN(4), TNR(5), TNXB(3), VASP(1), VAV1(3), VAV2(4), VAV3(5), VCL(6), VEGFA(1), VWF(6)	229981284	430	256	428	112	47	67	162	91	63	0	0.0582	1.000	1.000
420	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	129	ACTB(1), ACTG1(1), CHAD(1), COL11A1(9), COL11A2(3), COL17A1(6), COL1A1(2), COL1A2(4), COL2A1(4), COL3A1(5), COL4A1(5), COL4A2(2), COL4A4(7), COL4A6(5), COL5A1(3), COL5A2(4), COL5A3(10), COL6A3(13), COL6A6(7), COMP(2), DSC1(6), DSC2(1), DSC3(2), DSG1(2), DSG2(1), DSG3(4), DSG4(5), FN1(5), GJA1(2), GJA10(1), GJA5(1), GJA8(3), GJB3(1), GJB4(2), GJB5(2), GJB6(1), GJC3(1), GJD4(2), INA(1), ITGA6(3), ITGB4(2), KRT1(1), KRT10(3), KRT12(1), KRT13(2), KRT14(1), KRT19(1), KRT2(2), KRT23(1), KRT24(1), KRT25(2), KRT27(2), KRT28(2), KRT3(2), KRT35(1), KRT36(1), KRT4(4), KRT5(1), KRT6A(4), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(4), KRT73(2), KRT76(1), KRT77(1), KRT78(3), KRT79(2), KRT82(1), KRT83(2), KRT85(4), KRT86(1), KRT9(2), LAMA1(12), LAMA2(13), LAMA3(12), LAMA4(2), LAMB1(8), LAMB2(5), LAMB3(1), LAMB4(5), LAMC1(7), LAMC2(2), LAMC3(5), LMNA(3), NES(6), RELN(10), SPP1(1), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TNC(4), TNN(4), TNR(5), TNXB(3), VIM(2), VWF(6)	149735618	332	220	332	91	43	52	124	69	44	0	0.154	1.000	1.000
421	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	161	ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY7(2), ADCY8(2), ADCY9(4), ADORA2B(2), ADRA1A(1), ADRB2(1), ATP2A1(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(6), ATP2B3(1), ATP2B4(4), AVPR1B(3), BDKRB1(4), BDKRB2(4), CACNA1A(5), CACNA1B(2), CACNA1C(9), CACNA1D(8), CACNA1E(4), CACNA1F(3), CACNA1G(2), CACNA1I(1), CACNA1S(7), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CCKBR(2), CD38(2), CHP(1), CHRM2(5), CHRM3(5), CHRM5(2), CHRNA7(2), CYSLTR1(2), DRD1(2), EDNRA(2), EDNRB(1), EGFR(6), ERBB2(5), ERBB3(5), ERBB4(2), F2R(3), GNA11(1), GNA14(2), GNAL(2), GNAQ(1), GNAS(3), GRIN2A(4), GRIN2C(1), GRIN2D(3), GRM1(4), GRM5(2), GRPR(2), HRH1(1), HRH2(1), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), LHCGR(4), MYLK(6), MYLK2(2), NOS1(2), NOS3(2), P2RX1(1), P2RX3(2), PDE1A(1), PDE1B(1), PDE1C(4), PDGFRA(2), PDGFRB(3), PHKA1(5), PHKA2(2), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCD4(3), PLCE1(1), PLCG1(2), PLCG2(1), PLCZ1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), PTGFR(3), PTK2B(3), RYR1(11), RYR2(22), RYR3(8), SLC25A4(2), SLC25A5(1), SLC8A1(5), SLC8A3(6), TACR1(1), TACR3(2), TNNC2(1), TRHR(1), TRPC1(3), VDAC2(1), VDAC3(1)	168539726	359	218	355	88	50	44	138	89	38	0	0.0131	1.000	1.000
422	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	193	ABI2(1), ACTN2(7), ACTN3(2), ACTN4(1), APC(11), ARHGEF1(6), ARHGEF4(1), ARHGEF7(3), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), BDKRB1(4), BDKRB2(4), BRAF(2), CHRM2(5), CHRM3(5), CHRM5(2), CYFIP1(7), CYFIP2(1), DIAPH1(1), DIAPH2(5), DIAPH3(2), DOCK1(1), EGFR(6), EZR(1), F2(3), F2R(3), FGD1(5), FGF2(1), FGF23(3), FGF4(1), FGF5(2), FGF6(1), FGF8(1), FGF9(1), FGFR2(1), FGFR4(1), FN1(5), GNA12(1), GRLF1(5), GSN(3), IQGAP1(2), IQGAP2(9), IQGAP3(3), ITGA1(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAD(4), ITGAE(2), ITGAL(6), ITGAM(1), ITGAV(2), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), LIMK1(1), LIMK2(1), MOS(2), MRAS(1), MSN(2), MYH10(2), MYH14(2), MYH9(5), MYL2(1), MYL7(1), MYLK(6), MYLK2(2), NCKAP1(3), NCKAP1L(4), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDGFRA(2), PDGFRB(3), PFN4(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PPP1CB(1), PPP1R12A(2), PPP1R12B(3), PTK2(2), PXN(2), RHOA(3), ROCK2(2), RRAS(1), SCIN(4), SOS1(4), SOS2(1), SSH1(5), SSH2(1), SSH3(1), TIAM1(4), TIAM2(2), VAV1(3), VAV2(4), VAV3(5), VCL(6), WAS(2), WASF2(1), WASL(1)	172704056	327	218	326	88	38	41	124	86	38	0	0.123	1.000	1.000
423	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	219	ADCYAP1R1(2), ADORA2B(2), ADORA3(2), ADRA1A(1), ADRA2B(2), ADRB2(1), AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(4), BRS3(2), C3AR1(1), C5AR1(2), CALCR(5), CALCRL(4), CCKBR(2), CGA(1), CHRM2(5), CHRM3(5), CHRM5(2), CNR1(1), CNR2(1), CTSG(2), CYSLTR1(2), DRD1(2), DRD2(2), DRD3(1), EDNRA(2), EDNRB(1), F2(3), F2R(3), F2RL2(1), FPR1(1), FSHB(1), FSHR(7), GABBR1(3), GABBR2(3), GABRA1(4), GABRA2(3), GABRA3(2), GABRA4(4), GABRA5(2), GABRB1(3), GABRB3(2), GABRE(5), GABRG1(1), GABRG2(4), GABRQ(2), GABRR2(1), GH1(1), GHRHR(2), GHSR(2), GIPR(1), GLRA1(1), GLRA2(1), GLRA3(3), GNRHR(1), GPR156(1), GPR50(3), GRIA1(1), GRIA2(6), GRIA3(4), GRIA4(3), GRID1(5), GRID2(4), GRIK1(2), GRIK2(4), GRIK3(2), GRIK4(2), GRIK5(1), GRIN2A(4), GRIN2B(6), GRIN2C(1), GRIN2D(3), GRIN3A(4), GRM1(4), GRM3(2), GRM4(2), GRM5(2), GRM6(4), GRM7(4), GRM8(5), GRPR(2), GZMA(2), HCRTR1(1), HCRTR2(2), HRH1(1), HRH2(1), HRH4(2), HTR1A(4), HTR1E(3), HTR1F(3), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1), LEPR(5), LHCGR(4), MAS1(1), MC2R(4), MC3R(3), MC5R(1), MCHR2(2), MTNR1A(1), MTNR1B(1), NMUR2(3), NPBWR1(1), NPFFR2(2), NPY5R(2), NR3C1(2), OPRD1(1), OPRK1(1), P2RX1(1), P2RX3(2), P2RY1(1), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(2), P2RY6(1), PARD3(1), PPYR1(1), PRLHR(1), PRLR(2), PRSS3(1), PTGDR(1), PTGFR(3), PTH2R(2), SCTR(1), SSTR1(1), TAAR1(1), TAAR6(2), TAAR9(1), TACR1(1), TACR3(2), TRHR(1), TRPV1(1), TSHB(1), TSHR(4), VIPR2(1)	134928353	328	207	326	102	64	30	107	91	36	0	0.246	1.000	1.000
424	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	81	CD36(2), CD47(1), CHAD(1), COL11A1(9), COL11A2(3), COL1A1(2), COL1A2(4), COL2A1(4), COL3A1(5), COL4A1(5), COL4A2(2), COL4A4(7), COL4A6(5), COL5A1(3), COL5A2(4), COL5A3(10), COL6A3(13), COL6A6(7), DAG1(3), FN1(5), FNDC1(2), FNDC3A(2), FNDC5(1), GP6(1), HMMR(1), HSPG2(6), ITGA1(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAV(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), LAMA1(12), LAMA2(13), LAMA3(12), LAMA4(2), LAMB1(8), LAMB2(5), LAMB3(1), LAMB4(5), LAMC1(7), LAMC2(2), LAMC3(5), RELN(10), SDC1(4), SDC2(2), SPP1(1), SV2A(3), SV2B(3), SV2C(2), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TNC(4), TNN(4), TNR(5), TNXB(3), VWF(6)	137149719	283	192	283	77	43	44	108	56	32	0	0.140	1.000	1.000
425	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	230	ACVR1B(1), ACVR1C(2), ARRB2(1), ATF2(2), BRAF(2), CACNA1A(5), CACNA1B(2), CACNA1C(9), CACNA1D(8), CACNA1E(4), CACNA1F(3), CACNA1G(2), CACNA1I(1), CACNA1S(7), CACNA2D1(7), CACNA2D2(2), CACNA2D3(2), CACNA2D4(1), CACNB1(2), CACNB2(1), CACNB4(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG6(3), CACNG7(1), CDC25B(2), CHP(1), CHUK(1), DAXX(3), DDIT3(2), DUSP1(1), DUSP7(1), DUSP9(2), ECSIT(2), EGFR(6), ELK1(2), FGF2(1), FGF23(3), FGF4(1), FGF5(2), FGF6(1), FGF8(1), FGF9(1), FGFR2(1), FGFR4(1), FLNB(5), FLNC(4), FOS(1), GADD45B(1), GNA12(1), GRB2(2), IKBKB(2), IL1R2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K10(3), MAP3K12(2), MAP3K13(3), MAP3K14(1), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAP3K5(5), MAP3K6(1), MAP3K7(2), MAP4K1(2), MAP4K3(4), MAP4K4(1), MAPK14(2), MAPK7(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MAPKAPK5(1), MEF2C(1), MKNK1(2), MOS(2), MRAS(1), NFATC2(3), NFATC4(2), NFKB1(2), NLK(1), NTRK1(2), NTRK2(2), PAK1(1), PAK2(2), PDGFRA(2), PDGFRB(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), PTPN5(4), PTPRR(3), RAPGEF2(2), RASA1(2), RASA2(2), RASGRF1(6), RASGRF2(5), RASGRP1(1), RASGRP3(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), RPS6KA5(2), RRAS(1), SOS1(4), SOS2(1), SRF(1), STK4(1), TAOK1(3), TAOK2(1), TGFB2(1), TGFBR1(1), TGFBR2(3), TNF(1), TNFRSF1A(2), TRAF2(1), TRAF6(2)	170841717	266	189	266	77	41	33	102	55	35	0	0.257	1.000	1.000
426	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(1), ACTG1(1), ACTN2(7), ACTN3(2), ACTN4(1), AMOTL1(2), ASH1L(3), CASK(4), CGN(2), CLDN10(1), CLDN11(2), CLDN16(1), CLDN17(3), CLDN18(2), CLDN2(1), CLDN6(1), CSDA(1), CSNK2A1(2), CTNNA1(3), CTNNA3(5), CTNNB1(2), CTTN(1), EPB41(3), EPB41L2(1), EPB41L3(7), EXOC3(1), EXOC4(5), F11R(2), GNAI2(1), GNAI3(1), INADL(3), JAM3(1), LLGL1(1), LLGL2(5), MAGI1(1), MAGI2(4), MAGI3(3), MLLT4(3), MPDZ(5), MPP5(1), MRAS(1), MYH1(15), MYH10(2), MYH11(5), MYH13(7), MYH14(2), MYH15(5), MYH2(9), MYH3(4), MYH4(13), MYH6(1), MYH7(5), MYH7B(3), MYH8(7), MYH9(5), MYL2(1), MYL7(1), PARD3(1), PARD6A(1), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), PPP2R3A(3), PPP2R4(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(2), PTEN(5), RAB3B(1), RHOA(3), RRAS(1), SPTAN1(4), SRC(1), TJP1(3), TJP2(1), TJP3(2), YES1(1)	121831475	230	170	229	56	35	20	76	60	39	0	0.104	1.000	1.000
427	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ADRA1A(1), ADRB2(1), ANXA6(1), ARRB2(1), ATP1A4(4), ATP1B1(1), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(6), ATP2B3(1), CACNA1A(5), CACNA1B(2), CACNA1C(9), CACNA1D(8), CACNA1E(4), CACNA1S(7), CACNB1(2), CALM2(1), CALM3(1), CALR(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CASQ2(1), CHRM2(5), CHRM3(5), CHRM5(2), GJA1(2), GJA5(1), GJB3(1), GJB4(2), GJB5(2), GJB6(1), GNA11(1), GNAI2(1), GNAI3(1), GNAQ(1), GNB2(2), GNB4(1), GRK5(1), GRK6(1), ITPR1(4), ITPR2(7), ITPR3(5), MIB1(4), PLCB3(2), PRKACA(1), PRKACB(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), PRKCZ(2), PRKD1(3), RGS1(2), RGS18(2), RGS20(1), RGS4(3), RGS7(6), RGS9(3), RYR1(11), RYR2(22), RYR3(8), SLC8A1(5), SLC8A3(6), YWHAB(1)	120731608	238	167	237	70	44	23	89	56	26	0	0.276	1.000	1.000
428	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	120	ABL1(1), ABLIM1(1), ABLIM2(1), ABLIM3(2), CHP(1), CXCL12(1), DCC(8), DPYSL2(1), DPYSL5(2), EFNB1(1), EFNB2(1), EPHA1(4), EPHA2(2), EPHA3(6), EPHA4(1), EPHA6(2), EPHA7(7), EPHB1(4), EPHB2(2), EPHB3(3), EPHB4(1), EPHB6(2), GNAI2(1), GNAI3(1), L1CAM(8), LIMK1(1), LIMK2(1), LRRC4C(2), MET(4), NCK2(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NGEF(3), NRP1(3), NTN4(1), NTNG1(3), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PLXNA2(5), PLXNA3(3), PLXNB1(2), PLXNC1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(2), RASA1(2), RHOA(3), RND1(1), ROBO1(7), ROBO2(3), ROBO3(1), ROCK2(2), SEMA3A(4), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3G(2), SEMA4A(1), SEMA4B(2), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA5A(2), SEMA5B(2), SEMA6A(1), SEMA6C(2), SLIT1(5), SLIT2(5), SLIT3(4), SRGAP1(2), SRGAP2(4), UNC5B(3), UNC5C(4), UNC5D(4)	116864290	199	163	198	67	36	30	73	42	17	1	0.609	1.000	1.000
429	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	239	ACVR1(3), ACVR1B(1), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(1), BMPR1B(1), BMPR2(3), CCL15(3), CCL17(1), CCL21(1), CCL28(1), CCL4(1), CCL7(1), CCL8(1), CCR3(5), CCR6(1), CCR8(2), CCR9(2), CD40(1), CNTF(1), CNTFR(1), CSF1(1), CSF1R(2), CSF2RB(2), CSF3(1), CSF3R(2), CXCL12(1), CXCL13(1), CXCL16(1), CXCL9(1), CXCR3(3), EDA(3), EGFR(6), EPOR(2), FLT1(3), FLT3(3), FLT4(1), GH1(1), HGF(2), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNW1(1), IL10(2), IL11RA(1), IL12RB1(1), IL12RB2(2), IL13(1), IL17RA(2), IL17RB(2), IL18R1(2), IL18RAP(2), IL19(1), IL1R2(1), IL20(1), IL20RA(1), IL23R(1), IL24(2), IL25(1), IL26(2), IL28A(1), IL28RA(1), IL2RA(1), IL2RB(1), IL4R(1), IL5RA(1), IL6R(1), IL6ST(1), IL7R(4), IL8(3), INHBA(3), KDR(7), KIT(8), KITLG(1), LEPR(5), LIFR(2), LTA(1), LTBR(1), MET(4), MPL(1), NGFR(2), OSMR(2), PDGFC(1), PDGFRA(2), PDGFRB(3), PPBP(2), PRLR(2), TGFB2(1), TGFBR1(1), TGFBR2(3), TNF(1), TNFRSF10A(2), TNFRSF11A(2), TNFRSF1A(2), TNFRSF21(1), TNFRSF8(2), TNFRSF9(1), TNFSF10(1), TNFSF11(1), TNFSF18(1), TNFSF8(1), TPO(6), VEGFA(1), XCL2(1), XCR1(1)	111204912	197	158	197	47	29	32	54	56	26	0	0.0283	1.000	1.000
430	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	150	ADORA2B(2), ADORA3(2), ADRA1A(1), ADRB2(1), AGTR2(2), AVPR1B(3), AVPR2(1), BDKRB1(4), BDKRB2(4), BRS3(2), C3AR1(1), CCKBR(2), CCR3(5), CCR6(1), CCR8(2), CCR9(2), CHML(4), CHRM2(5), CHRM3(5), CHRM5(2), CNR1(1), CNR2(1), CXCR3(3), DRD1(2), DRD2(2), DRD3(1), EDNRA(2), EDNRB(1), F2R(3), F2RL2(1), FPR1(1), FSHR(7), GALT(1), GHSR(2), GPR173(1), GPR174(1), GPR3(1), GPR37(2), GPR37L1(1), GPR4(2), GPR50(3), GPR77(1), GPR85(1), GRPR(2), HCRTR1(1), HCRTR2(2), HRH1(1), HRH2(1), HTR1A(4), HTR1E(3), HTR1F(3), HTR2A(4), HTR2C(6), HTR4(1), HTR5A(4), HTR6(2), HTR7(1), LHCGR(4), MAS1(1), MC3R(3), MC5R(1), MTNR1A(1), MTNR1B(1), NMUR2(3), NPY5R(2), OPN1SW(1), OPN3(1), OPRD1(1), OPRK1(1), OR10A5(1), OR11A1(3), OR12D3(3), OR5V1(5), OR7A5(1), OR7C1(2), OR8B8(1), P2RY1(1), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(2), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(3), RRH(1), SSTR1(1), SUCNR1(1), TRHR(1)	71599643	182	143	181	55	35	17	66	48	16	0	0.128	1.000	1.000
431	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(1), ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ARRB2(1), ATF1(2), ATF2(2), ATP2A2(1), ATP2A3(1), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CNN2(1), CORIN(3), CREB3(1), ETS2(1), FOS(1), GABPA(3), GBA2(3), GJA1(2), GNAQ(1), GNB2(2), GNB4(1), GRK5(1), GRK6(1), GUCY1A3(2), IGFBP1(1), IGFBP6(1), ITPR1(4), ITPR2(7), ITPR3(5), MIB1(4), MYL2(1), MYL4(2), MYLK2(2), NFKB1(2), NOS1(2), NOS3(2), PDE4B(1), PDE4D(1), PLCB3(2), PLCG1(2), PLCG2(1), PRKACA(1), PRKACB(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCH(1), PRKCQ(2), PRKCZ(2), PRKD1(3), RAMP3(1), RGS1(2), RGS18(2), RGS20(1), RGS4(3), RGS7(6), RGS9(3), RYR1(11), RYR2(22), RYR3(8), SLC8A1(5), TNXB(3), YWHAB(1)	109602898	190	143	189	59	32	21	72	47	18	0	0.521	1.000	1.000
432	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	123	ALCAM(1), CADM1(2), CADM3(2), CD2(3), CD22(3), CD226(1), CD274(1), CD34(1), CD40(1), CD6(1), CD80(2), CD8A(1), CD8B(1), CDH1(2), CDH2(4), CDH3(2), CDH4(3), CDH5(4), CLDN10(1), CLDN11(2), CLDN16(1), CLDN17(3), CLDN18(2), CLDN2(1), CLDN6(1), CNTN1(6), CNTN2(1), CNTNAP1(2), CNTNAP2(12), CTLA4(1), F11R(2), GLG1(4), HLA-A(1), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-G(3), ICAM1(1), ICAM2(1), ICAM3(2), ICOS(1), ITGA4(3), ITGA6(3), ITGA8(6), ITGAL(6), ITGAM(1), ITGAV(2), ITGB2(2), ITGB7(3), JAM3(1), L1CAM(8), MAG(1), MPZ(2), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(1), NFASC(5), NLGN1(2), NLGN3(2), NRCAM(3), NRXN1(5), NRXN2(4), NRXN3(5), PTPRC(3), PTPRF(5), PTPRM(3), PVRL1(1), SDC1(4), SDC2(2), SELE(2), SELP(3), SIGLEC1(3), VCAM1(1), VCAN(5)	93162636	195	141	195	45	28	32	64	50	21	0	0.00995	1.000	1.000
433	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	138	ADA(1), ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ADK(1), ADSL(1), ADSS(1), ADSSL1(1), AK1(1), AK2(1), AK5(3), AK7(1), ALLC(2), AMPD1(4), AMPD2(4), AMPD3(1), ATIC(2), CANT1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD1(2), ENTPD3(1), ENTPD5(1), GART(3), GDA(2), GMPR2(3), GMPS(3), GUCY1A3(2), GUCY2C(4), GUCY2F(3), ITPA(1), NPR1(3), NPR2(3), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2), NUDT5(1), PAPSS1(1), PDE10A(4), PDE11A(3), PDE1A(1), PDE1C(4), PDE2A(4), PDE3B(1), PDE4A(3), PDE4B(1), PDE4C(1), PDE4D(1), PDE6H(1), PDE7A(1), PDE7B(2), PDE8A(1), PFAS(3), PKLR(1), POLA1(2), POLA2(1), POLD2(3), POLD3(1), POLE(2), POLE2(2), POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3A(1), POLR3B(1), PPAT(2), PRPS1L1(2), PRUNE(2), RFC5(1), RRM1(1), RRM2B(2), XDH(2)	105980372	164	135	161	57	26	14	58	44	22	0	0.851	1.000	1.000
434	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	136	APC(11), AXIN1(1), AXIN2(2), BTRC(1), CAMK2B(1), CAMK2D(2), CHD8(6), CHP(1), CREBBP(11), CSNK1A1L(1), CSNK1E(1), CSNK2A1(2), CTBP2(2), CTNNB1(2), CUL1(2), CXXC4(1), DAAM1(2), DAAM2(2), DKK1(1), DKK2(3), DVL3(1), EP300(2), FBXW11(1), FZD1(1), FZD3(1), FZD4(1), FZD5(2), FZD7(2), LEF1(1), LRP5(1), LRP6(3), MAP3K7(2), MAPK8(1), MAPK9(1), MMP7(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NLK(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PORCN(3), PPARD(3), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(4), PRICKLE2(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), RHOA(3), ROCK2(2), SENP2(1), SMAD4(1), TBL1X(1), TBL1XR1(2), TCF7L1(1), TCF7L2(2), VANGL2(1), WIF1(2), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3), WNT8A(1), WNT9A(1), WNT9B(1)	97459766	168	129	167	34	26	29	61	29	23	0	0.0138	1.000	1.000
435	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA1(1), ACTN2(7), ACTN3(2), ACTN4(1), DMD(7), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH3(4), MYH6(1), MYH7(5), MYH8(7), MYL2(1), MYL4(2), MYOM1(4), NEB(9), TMOD1(1), TNNC2(1), TNNT1(1), TPM2(1), TTN(106), VIM(2)	88271212	171	129	170	39	28	18	57	48	19	1	0.149	1.000	1.000
436	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), CSNK1D(1), DRD1(2), DRD2(2), EGFR(6), GJA1(2), GNA11(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(3), GRB2(2), GRM1(4), GRM5(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HTR2A(4), HTR2C(6), ITPR1(4), ITPR2(7), ITPR3(5), MAP3K2(3), MAPK7(2), NPR1(3), NPR2(3), PDGFC(1), PDGFD(1), PDGFRA(2), PDGFRB(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), PRKG1(3), SOS1(4), SOS2(1), SRC(1), TJP1(3), TUBA1B(1), TUBA3C(4), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2C(1), TUBB3(3), TUBB4(2), TUBB4Q(1), TUBB8(2)	82682757	164	126	162	45	24	22	69	36	13	0	0.201	1.000	1.000
437	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	142	CBLB(1), CBLC(2), CNTF(1), CNTFR(1), CREBBP(11), CSF2RB(2), CSF3(1), CSF3R(2), EP300(2), EPOR(2), GH1(1), GRB2(2), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNW1(1), IL10(2), IL11RA(1), IL12RB1(1), IL12RB2(2), IL13(1), IL19(1), IL20(1), IL20RA(1), IL23R(1), IL24(2), IL26(2), IL28A(1), IL28RA(1), IL2RA(1), IL2RB(1), IL4R(1), IL5RA(1), IL6R(1), IL6ST(1), IL7R(4), IRF9(1), JAK2(1), JAK3(4), LEPR(5), LIFR(2), MPL(1), OSMR(2), PIAS2(3), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PRLR(2), PTPN11(1), SOCS4(1), SOCS5(3), SOS1(4), SOS2(1), SPRED1(1), SPRED2(3), SPRY1(2), SPRY2(1), SPRY4(1), STAM(1), STAM2(1), STAT1(2), STAT2(2), STAT3(1), STAT4(2), STAT5B(3), STAT6(4), TPO(6), TYK2(2)	90613857	147	126	147	44	17	15	51	43	21	0	0.631	1.000	1.000
438	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	103	ACTN2(7), ACTN3(2), ACTN4(1), ARHGAP5(2), CDH5(4), CLDN10(1), CLDN11(2), CLDN16(1), CLDN17(3), CLDN18(2), CLDN2(1), CLDN6(1), CTNNA1(3), CTNNA3(5), CTNNB1(2), CXCL12(1), CYBB(1), EZR(1), F11R(2), GNAI2(1), GNAI3(1), GRLF1(5), ICAM1(1), ITGA4(3), ITGAL(6), ITGAM(1), ITGB2(2), ITK(7), JAM3(1), MAPK14(2), MLLT4(3), MMP2(1), MMP9(1), MSN(2), MYL2(1), MYL7(1), NCF2(6), NCF4(1), NOX3(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PLCG2(1), PRKCA(2), PRKCG(2), PTK2(2), PTK2B(3), PTPN11(1), PXN(2), RAPGEF4(1), RASSF5(1), RHOA(3), RHOH(1), ROCK2(2), VASP(1), VAV1(3), VAV2(4), VAV3(5), VCAM1(1), VCL(6)	76749808	150	124	149	43	16	19	54	40	21	0	0.418	1.000	1.000
439	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	89	ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), CACNA1C(9), CACNA1D(8), CACNA1F(3), CACNA1S(7), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CGA(1), EGFR(6), ELK1(2), FSHB(1), GNA11(1), GNAQ(1), GNAS(3), GNRH2(1), GNRHR(1), GRB2(2), ITPR1(4), ITPR2(7), ITPR3(5), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAPK14(2), MAPK7(2), MAPK8(1), MAPK9(1), MMP2(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLD1(2), PLD2(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PTK2B(3), SOS1(4), SOS2(1), SRC(1)	80574859	151	124	149	49	17	18	66	33	17	0	0.718	1.000	1.000
440	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	120	ACACB(8), BRAF(2), CALM2(1), CALM3(1), CBLB(1), CBLC(2), ELK1(2), EXOC7(1), FOXO1(1), G6PC(1), G6PC2(1), GCK(1), GRB2(2), GYS1(1), GYS2(3), IKBKB(2), INPP5D(4), INSR(5), IRS1(3), IRS4(8), LIPE(1), MAPK8(1), MAPK9(1), MKNK1(2), PCK2(1), PDE3A(3), PDE3B(1), PDPK1(1), PFKM(1), PFKP(2), PHKA1(5), PHKA2(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PKLR(1), PPARGC1A(3), PPP1CB(1), PPP1R3A(10), PPP1R3B(2), PRKAA2(2), PRKAB2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAG3(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCI(1), PRKCZ(2), PTPRF(5), PYGB(2), PYGM(3), RAPGEF1(3), RHEB(1), RPS6(1), RPS6KB2(1), SHC1(1), SHC4(2), SOCS4(1), SORBS1(1), SOS1(4), SOS2(1), SREBF1(1), TRIP10(2), TSC2(3)	94987571	154	123	154	51	19	18	58	38	21	0	0.804	1.000	1.000
441	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	106	ADA(1), ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADK(1), ADSL(1), ADSS(1), AK1(1), AK2(1), AK5(3), ALLC(2), AMPD1(4), AMPD2(4), AMPD3(1), ATIC(2), ATP1B1(1), ATP5A1(1), ATP5C1(1), ATP5G2(1), ATP5G3(1), ATP5J2(1), CANT1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD1(2), GART(3), GDA(2), GMPS(3), GUCY1A3(2), GUCY2C(4), GUCY2F(3), ITPA(1), NPR1(3), NPR2(3), NT5E(2), PAPSS1(1), PDE1A(1), PDE4A(3), PDE4B(1), PDE4C(1), PDE4D(1), PDE6B(1), PDE6C(4), PDE7B(2), PDE8A(1), PFAS(3), PKLR(1), POLB(2), POLD2(3), POLE(2), POLG(2), POLQ(3), POLR2B(4), POLR2C(1), POLR2H(1), PPAT(2), PRPS1L1(2), PRUNE(2), RRM1(1)	81568933	134	113	131	37	21	16	46	31	20	0	0.388	1.000	1.000
442	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(1), ANAPC1(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ATM(8), ATR(3), BUB1(2), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB3(4), CCNH(1), CDC14A(1), CDC16(2), CDC20(4), CDC23(1), CDC25A(1), CDC25B(2), CDC27(5), CDC6(1), CDC7(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CHEK2(3), CREBBP(11), CUL1(2), DBF4(3), E2F2(2), E2F3(1), EP300(2), ESPL1(3), GADD45B(1), HDAC1(1), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), ORC1L(2), ORC2L(2), PLK1(2), PRKDC(7), RBL1(1), RBL2(3), SKP2(2), SMAD4(1), SMC1A(5), SMC1B(4), TFDP1(3), TGFB2(1), YWHAB(1), YWHAE(2), YWHAG(1)	86003366	126	112	126	30	21	15	40	27	23	0	0.307	1.000	1.000
443	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), ASIP(1), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L4(1), CREBBP(11), CTNNB1(2), DCT(3), DVL3(1), EDNRB(1), EP300(2), FZD1(1), FZD3(1), FZD4(1), FZD5(2), FZD7(2), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(3), KIT(8), KITLG(1), LEF1(1), MITF(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), POMC(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), TCF7L1(1), TCF7L2(2), TYR(1), TYRP1(1), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3), WNT8A(1), WNT9A(1), WNT9B(1)	65144998	130	109	127	37	25	20	43	22	20	0	0.214	1.000	1.000
444	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	CAPN10(1), CAPN11(1), CAPN3(2), CAPN5(1), CAPN6(2), CAPN7(2), CAPN9(3), DOCK1(1), GRB2(2), ITGA10(3), ITGA2(3), ITGA2B(7), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), ITGAD(4), ITGAE(2), ITGAL(6), ITGAM(1), ITGAV(2), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(2), ITGB6(2), ITGB7(3), MAP2K6(1), MAPK6(2), MAPK7(2), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PDPK1(1), PIK3R2(1), PTK2(2), PXN(2), RAPGEF1(3), ROCK2(2), SHC1(1), SORBS1(1), SOS1(4), SRC(1), TNS1(3), VASP(1), VAV2(4), VAV3(5), VCL(6)	84757557	127	108	127	33	15	16	46	34	16	0	0.163	1.000	1.000
445	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(2), AMY2A(1), AMY2B(2), ASCC3(5), ATP13A2(2), DDX18(2), DDX23(1), DDX4(3), DDX52(1), DDX54(3), DDX55(1), ENPP1(3), ENPP3(3), ENTPD7(1), EP400(3), ERCC2(1), ERCC3(1), G6PC(1), G6PC2(1), GAA(1), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), GYS2(3), HK1(1), HK2(2), HK3(4), IFIH1(3), MGAM(6), MOV10L1(1), NUDT5(1), PYGB(2), PYGM(3), RAD54L(4), RUVBL2(2), SETX(2), SI(10), SKIV2L2(1), SMARCA2(3), UGDH(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1), UXS1(2)	78881653	120	106	117	24	17	14	42	31	16	0	0.0482	1.000	1.000
446	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	BRAF(2), CD244(2), CHP(1), FCGR3B(1), GRB2(2), HLA-A(1), HLA-E(2), HLA-G(3), ICAM1(1), ICAM2(1), IFNA1(2), IFNA13(1), IFNA14(1), IFNA21(1), IFNA5(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNB1(1), ITGAL(6), ITGB2(2), KIR2DL1(1), KIR2DL3(3), KIR2DL4(2), KIR3DL1(3), KIR3DL2(1), KLRC1(1), KLRC2(1), KLRC3(1), KLRK1(1), LCK(1), LCP2(1), MICB(2), NCR1(2), NCR2(1), NCR3(2), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), PAK1(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), SHC1(1), SHC4(2), SOS1(4), SOS2(1), TNF(1), TNFRSF10A(2), TNFSF10(1), VAV1(3), VAV2(4), VAV3(5), ZAP70(1)	69791138	126	106	126	39	13	19	47	32	15	0	0.536	1.000	1.000
447	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(6), ABCA10(3), ABCA12(7), ABCA13(11), ABCA3(7), ABCA4(7), ABCA5(3), ABCA6(3), ABCA8(3), ABCA9(5), ABCB1(5), ABCB10(1), ABCB11(2), ABCB4(6), ABCB5(3), ABCB7(2), ABCB8(1), ABCC1(3), ABCC10(5), ABCC11(3), ABCC12(2), ABCC2(1), ABCC3(1), ABCC4(1), ABCC5(3), ABCC6(3), ABCC8(2), ABCC9(3), ABCD2(3), ABCD3(1), ABCG1(2), ABCG4(2), ABCG8(2), CFTR(2)	73537162	114	102	114	29	21	17	42	26	8	0	0.0653	1.000	1.000
448	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	CARD11(1), CBLB(1), CBLC(2), CD3E(2), CD3G(1), CD8A(1), CD8B(1), CHP(1), CHUK(1), CTLA4(1), FOS(1), GRB2(2), ICOS(1), IKBKB(2), IL10(2), ITK(7), LCK(1), LCP2(1), MALT1(1), MAP3K14(1), NCK2(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDK1(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(3), RASGRP1(1), RHOA(3), SOS1(4), SOS2(1), TNF(1), VAV1(3), VAV2(4), VAV3(5), ZAP70(1)	63284548	112	100	112	35	10	16	45	27	14	0	0.698	1.000	1.000
449	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	69	CALM2(1), CALM3(1), CDS1(1), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), DGKI(4), IMPA2(1), INPP1(1), INPP4B(2), INPP5B(2), INPP5D(4), INPPL1(1), ITPK1(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), OCRL(1), PI4KB(5), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3C3(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCD4(3), PLCE1(1), PLCG1(2), PLCG2(1), PLCZ1(1), PRKCA(2), PRKCG(2), PTEN(5), SYNJ1(6)	78085295	121	99	121	36	11	21	44	35	10	0	0.531	1.000	1.000
450	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	BRAF(2), C7orf16(1), CACNA1A(5), GNA11(1), GNA12(1), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(3), GRIA1(1), GRIA2(6), GRIA3(4), GRID2(4), GRM1(4), GRM5(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), IGF1R(1), ITPR1(4), ITPR2(7), ITPR3(5), LYN(2), NOS1(2), NOS3(2), NPR1(3), NPR2(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), PRKCA(2), PRKCG(2), PRKG1(3), RYR1(11)	70069183	121	99	120	39	16	16	43	31	15	0	0.619	1.000	1.000
451	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(1), ACTG1(1), ACTN2(7), ACTN3(2), ACTN4(1), ACVR1B(1), ACVR1C(2), CDH1(2), CREBBP(11), CSNK2A1(2), CTNNA1(3), CTNNA3(5), CTNNB1(2), EGFR(6), EP300(2), ERBB2(5), IGF1R(1), INSR(5), IQGAP1(2), LEF1(1), LMO7(2), MAP3K7(2), MET(4), MLLT4(3), NLK(1), PARD3(1), PTPRB(2), PTPRF(5), PTPRJ(2), PTPRM(3), PVRL1(1), PVRL4(2), RHOA(3), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(1), SRC(1), SSX2IP(1), TCF7L1(1), TCF7L2(2), TGFBR1(1), TGFBR2(3), TJP1(3), VCL(6), WAS(2), WASF2(1), WASF3(1), WASL(1), YES1(1)	77872726	122	98	120	24	13	16	41	32	20	0	0.0415	1.000	1.000
452	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(3), ADCY2(11), ADCY3(2), ADCY4(1), ADCY5(3), ADCY6(1), ADCY7(2), ADCY8(2), ADCY9(4), AKAP1(1), AKAP12(1), AKAP3(2), AKAP4(1), AKAP6(5), AKAP7(1), AKAP8(1), AKAP9(7), ARHGEF1(6), CALM2(1), CALM3(1), GNA11(1), GNA12(1), GNA14(2), GNAI2(1), GNAI3(1), GNAL(2), GNAQ(1), GNB2(2), ITPR1(4), PALM2(1), PDE1A(1), PDE1B(1), PDE1C(4), PDE4A(3), PDE4B(1), PDE4C(1), PDE4D(1), PDE7A(1), PDE7B(2), PDE8A(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(2), PRKD1(3), PRKD3(2), RHOA(3), RRAS(1)	74971234	119	97	118	45	20	14	43	28	14	0	0.889	1.000	1.000
453	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(3), ALG1(3), ALG10(1), ALG10B(4), ALG11(2), ALG2(3), ALG8(2), ALG9(1), B3GNT1(1), B3GNT2(2), B4GALT2(1), B4GALT5(3), B4GALT7(1), CHPF(1), CHST12(1), CHST14(1), CHST2(2), CHSY1(1), DAD1(2), DPAGT1(1), EXT1(1), EXTL3(2), FUT8(1), GALNT1(3), GALNT12(1), GALNT13(3), GALNT2(1), GALNT3(1), GALNT4(2), GALNT5(1), GALNT6(2), GALNT8(1), GALNTL2(1), GALNTL5(1), GANAB(3), GCNT3(2), GCNT4(4), HS2ST1(1), HS3ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), MAN1A1(2), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT3(1), MGAT4A(1), MGAT5(3), MGAT5B(2), NDST2(3), NDST4(2), OGT(3), RPN1(2), RPN2(2), ST3GAL2(2), ST3GAL3(3), ST6GALNAC1(1), STT3B(3), UST(2), WBSCR17(1), XYLT1(4), XYLT2(1)	69366755	114	97	114	23	20	15	39	24	16	0	0.0292	1.000	1.000
454	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(3), ASH2L(1), CARM1(3), CTCFL(3), EHMT2(2), EZH1(4), FBXO11(2), HCFC1(3), HSF4(1), JMJD6(1), MEN1(1), MLL(10), MLL2(2), MLL3(13), MLL4(2), MLL5(5), NSD1(5), OGT(3), PAXIP1(2), PPP1CB(1), PRDM2(2), PRDM7(2), PRDM9(6), PRMT1(1), PRMT5(2), PRMT8(2), SATB1(2), SETD1A(6), SETD2(7), SETD7(1), SETD8(1), SETDB1(3), SETDB2(1), SETMAR(1), STK38(3), SUV39H2(1), SUV420H1(2), SUZ12(1), WHSC1(2)	74988679	113	96	113	23	12	10	42	34	15	0	0.103	1.000	1.000
455	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	89	ACTB(1), CABIN1(2), CALM2(1), CALM3(1), CAMK2B(1), CAMK4(4), CD3E(2), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(11), CSNK2A1(2), CTLA4(1), EGR2(2), EP300(2), FKBP1B(1), FOS(1), GATA3(3), GRLF1(5), GSK3A(1), ICOS(1), IFNA1(2), IFNB1(1), IL10(2), IL13(1), IL2RA(1), IL8(3), ITK(7), MAPK14(2), MAPK8(1), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(2), NCK2(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NFKBIB(1), NFKBIE(1), NPPB(3), NUP214(1), OPRD1(1), PAK1(1), PPP3CC(1), PTPRC(3), RELA(1), SLA(1), TNF(1), TRAF2(1), VAV1(3), VAV2(4), VAV3(5)	56939383	109	96	109	30	8	16	34	28	23	0	0.417	1.000	1.000
456	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(1), ARHGEF7(3), BRAF(2), CSE1L(1), DOCK1(1), EPHB2(2), GRB2(2), GRB7(1), GRLF1(5), ITGA1(2), ITGA10(3), ITGA2(3), ITGA3(3), ITGA4(3), ITGA5(1), ITGA6(3), ITGA7(1), ITGA8(6), MAP2K4(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MRAS(1), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PIK3CA(3), PIK3CB(5), PKLR(1), PLCG1(2), PLCG2(1), PTEN(5), PTK2(2), ROCK2(2), SHC1(1), SOS1(4), SOS2(1), SRC(1), TLN2(5), VASP(1), WAS(2)	76917454	105	92	105	31	10	12	35	28	20	0	0.468	1.000	1.000
457	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(2), BDKRB1(4), BDKRB2(4), C2(2), C3(1), C3AR1(1), C4BPA(1), C4BPB(1), C5(3), C5AR1(2), C6(4), C7(3), C8A(1), C8B(2), C9(1), CD46(1), CD55(1), CFH(4), CPB2(1), CR1(3), CR2(2), F10(1), F11(1), F13A1(2), F13B(1), F2(3), F2R(3), F3(1), F5(8), F7(1), F8(6), F9(1), FGA(3), FGB(2), KLKB1(1), KNG1(1), MASP1(3), MASP2(3), MBL2(1), PLAU(2), PLAUR(1), PLG(4), PROS1(1), SERPINA5(2), SERPINC1(2), SERPIND1(1), SERPINE1(2), VWF(6)	58881262	107	91	107	27	14	11	43	28	11	0	0.220	1.000	1.000
458	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(3), ADCY8(2), BRAF(2), CACNA1C(9), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), CAMK4(4), CHP(1), CREBBP(11), EP300(2), GNAQ(1), GRIA1(1), GRIA2(6), GRIN2A(4), GRIN2B(6), GRIN2C(1), GRIN2D(3), GRM1(4), GRM5(2), ITPR1(4), ITPR2(7), ITPR3(5), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PPP1CB(1), PPP1R12A(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(2), PRKCG(2), RPS6KA1(1), RPS6KA2(1)	63612456	112	90	111	31	15	15	35	31	16	0	0.369	1.000	1.000
459	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(1), ABL2(1), BRAF(2), CAMK2B(1), CAMK2D(2), CBLB(1), CBLC(2), CDKN1A(1), CDKN1B(1), EGFR(6), ELK1(2), ERBB2(5), ERBB3(5), ERBB4(2), GRB2(2), MAP2K4(2), MAPK8(1), MAPK9(1), NCK2(1), NRG1(4), NRG2(3), NRG3(1), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG1(2), PLCG2(1), PRKCA(2), PRKCG(2), PTK2(2), RPS6KB2(1), SHC1(1), SHC4(2), SOS1(4), SOS2(1), SRC(1), STAT5B(3)	63880856	99	89	98	35	8	18	38	24	11	0	0.772	1.000	1.000
460	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(3), ACVR1B(1), ACVR1C(2), ACVR2A(1), ACVR2B(1), ACVRL1(2), AMHR2(1), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMPR1B(1), BMPR2(3), CHRD(2), COMP(2), CREBBP(11), CUL1(2), E2F4(1), E2F5(3), EP300(2), FST(1), INHBA(3), LEFTY1(1), LTBP1(3), NODAL(1), PITX2(1), PPP2CA(2), PPP2R1A(3), PPP2R1B(1), PPP2R2A(2), PPP2R2B(1), RBL1(1), RBL2(3), RHOA(3), ROCK2(2), RPS6KB2(1), SMAD1(1), SMAD4(1), SMURF1(2), TFDP1(3), TGFB2(1), TGFBR1(1), TGFBR2(3), THBS1(3), THBS2(6), THBS3(3), THBS4(1), TNF(1), ZFYVE9(3)	62720319	100	88	100	26	15	11	35	21	18	0	0.362	1.000	1.000
461	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	79	ACVR1(3), ACVR1B(1), ACVRL1(2), BMPR2(3), BUB1(2), CDKL2(1), CDS1(1), CLK4(1), CSNK2A1(2), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), INPP1(1), INPP4B(2), INPPL1(1), ITPKB(4), MAP3K10(3), MOS(2), NEK1(4), NEK3(1), OCRL(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(5), PIK3CG(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCG1(2), PLCG2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), PRKCZ(2), PRKD1(3), PRKG1(3), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), TGFBR1(1)	71943528	106	86	106	41	17	11	39	28	11	0	0.936	1.000	1.000
462	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(1), ATM(8), BUB1(2), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(1), CCNB3(4), CCNH(1), CDAN1(3), CDC14A(1), CDC20(4), CDC25A(1), CDC25B(2), CDC6(1), CDC7(1), CDH1(2), CDKN1A(1), CHEK2(3), DTX4(2), E2F2(2), E2F3(1), E2F4(1), E2F5(3), EP300(2), ESPL1(3), HDAC1(1), HDAC3(2), HDAC4(1), HDAC5(1), HDAC6(3), MAD1L1(1), MAD2L2(1), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MPEG1(1), MPL(1), ORC1L(2), ORC2L(2), PLK1(2), PRKDC(7), RBL1(1), SKP2(2), SMAD4(1), TBC1D8(4), TFDP1(3)	70674401	98	85	98	25	19	13	27	23	16	0	0.262	1.000	1.000
463	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	49	ADORA3(2), CCKBR(2), CCR3(5), CELSR2(6), CELSR3(6), CHRM2(5), CHRM3(5), CXCR3(3), EDNRA(2), EMR2(2), EMR3(7), F2R(3), FSHR(7), GHRHR(2), GNRHR(1), GPR116(3), GPR132(2), GPR133(2), GPR143(1), GPR55(1), GPR56(1), GPR77(1), GRM1(4), GRPR(2), HRH4(2), LGR6(2), LPHN2(4), LPHN3(6), OR2M4(1), OR8G2(1), P2RY11(1), P2RY13(3), PTGFR(3), TSHR(4), VN1R1(1)	36560689	103	83	102	33	19	12	37	26	9	0	0.442	1.000	1.000
464	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	66	ACACB(8), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(1), CAMKK1(1), CD36(2), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(3), IRS4(8), JAK2(1), JAK3(4), LEPR(5), MAPK8(1), MAPK9(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PCK2(1), POMC(1), PPARA(1), PPARGC1A(3), PRKAA2(2), PRKAB2(1), PRKAG1(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(1), RELA(1), RXRA(2), RXRB(2), RXRG(1), SLC2A1(2), STAT3(1), TNF(1), TNFRSF1A(2), TRAF2(1), TYK2(2)	52144295	93	82	93	22	15	18	23	21	16	0	0.0808	1.000	1.000
465	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	80	ATF2(2), BRAF(2), CHUK(1), DAXX(3), ELK1(2), FOS(1), GRB2(2), IKBKB(2), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K10(3), MAP3K12(2), MAP3K13(3), MAP3K14(1), MAP3K2(3), MAP3K3(1), MAP3K4(2), MAP3K5(5), MAP3K6(1), MAP3K7(2), MAP3K9(1), MAP4K1(2), MAP4K3(4), MAP4K4(1), MAPK14(2), MAPK6(2), MAPK7(2), MAPK8(1), MAPK9(1), MAPKAPK5(1), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(2), NFKB1(2), NFKBIA(2), PAK1(1), PAK2(2), RELA(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(1), RPS6KA5(2), RPS6KB2(1), SHC1(1), STAT1(2), TGFB2(1), TGFBR1(1), TRAF2(1)	59692950	85	80	85	23	10	15	30	18	12	0	0.407	1.000	1.000
466	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(2), APAF1(2), ATM(8), BIRC3(2), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CHP(1), CHUK(1), CSF2RB(2), DFFB(1), FADD(1), IKBKB(2), IRAK1(3), IRAK2(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(2), NFKBIA(2), NTRK1(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), RELA(1), TNF(1), TNFRSF10A(2), TNFRSF1A(2), TNFSF10(1), TRAF2(1)	52068316	81	71	81	26	9	12	29	21	10	0	0.730	1.000	1.000
467	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	BTK(2), CARD11(1), CD19(2), CD22(3), CD79A(1), CHP(1), CHUK(1), CR2(2), FOS(1), IFITM1(1), IKBKB(2), INPP5D(4), LILRB3(1), LYN(2), MALT1(1), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), RASGRP3(2), VAV1(3), VAV2(4), VAV3(5)	45218781	77	71	77	23	8	9	27	23	10	0	0.569	1.000	1.000
468	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	BCR(4), BTK(2), CD19(2), CD22(3), CR2(2), DAG1(3), GRB2(2), GSK3A(1), INPP5D(4), ITPR1(4), ITPR2(7), ITPR3(5), LYN(2), MAP4K1(2), NFATC1(1), NFATC2(3), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PTPRC(3), SHC1(1), SOS1(4), SOS2(1), VAV1(3)	46415105	70	67	70	24	5	10	31	16	8	0	0.783	1.000	1.000
469	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	68	BTK(2), GAB2(5), GRB2(2), IL13(1), INPP5D(4), LCP2(1), LYN(2), MAP2K4(2), MAP2K6(1), MAPK14(2), MAPK8(1), MAPK9(1), MS4A2(1), PDK1(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCG1(2), PLCG2(1), PRKCA(2), PRKCE(1), SOS1(4), SOS2(1), TNF(1), VAV1(3), VAV2(4), VAV3(5)	44091573	73	66	73	26	4	9	30	22	8	0	0.868	1.000	1.000
470	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(2), CDC40(1), CLK4(1), COL2A1(4), CPSF2(2), CPSF3(1), CSTF2T(2), DDIT3(2), DDX1(2), DHX15(1), DHX16(3), DHX8(2), DHX9(3), DICER1(2), METTL3(1), NONO(2), PABPN1(2), PRPF3(1), PRPF4(2), PRPF4B(1), PRPF8(1), PTBP1(1), PTBP2(1), RNGTT(1), RNPS1(1), SF3A1(3), SF3B2(1), SF3B4(4), SF4(2), SFRS16(1), SFRS7(1), SNRPA(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(1), SRPK2(2), SRRM1(3), SUPT5H(3), U2AF2(1), XRN2(2)	67690773	72	66	72	15	10	13	22	14	13	0	0.143	1.000	1.000
471	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	CDKN1B(1), CREB3(1), EBP(2), ERBB4(2), F2RL2(1), GRB2(2), GSK3A(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS4(8), MET(4), NOLC1(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PARD3(1), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PREX1(6), PTEN(5), PTK2(2), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(4), SOS2(1), TSC2(3), YWHAB(1), YWHAE(2), YWHAG(1)	47293164	77	66	77	29	11	12	28	15	11	0	0.861	1.000	1.000
472	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(1), ADAM17(1), ATP6AP1(3), ATP6V0A2(2), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), CHUK(1), EGFR(6), F11R(2), IKBKB(2), IL8(3), JAM3(1), LYN(2), MAP2K4(2), MAP3K14(1), MAPK14(2), MAPK8(1), MAPK9(1), MET(4), NFKB1(2), NFKBIA(2), NOD1(1), PAK1(1), PLCG1(2), PLCG2(1), PTPN11(1), PTPRZ1(12), RELA(1), SRC(1), TJP1(3)	44801952	69	64	68	18	8	11	21	18	11	0	0.374	1.000	1.000
473	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	45	ACOX1(1), CD36(2), CPT1B(5), CREBBP(11), DUSP1(1), EHHADH(2), EP300(2), HSD17B4(1), LPL(1), ME1(2), NCOA1(2), NCOR1(1), NCOR2(3), NFKBIA(2), NR1H3(5), NR2F1(2), NRIP1(2), PIK3CA(3), PIK3R1(2), PPARA(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), PTGS2(1), RELA(1), RXRA(2), STAT5B(3), TNF(1)	37447744	67	63	67	18	4	8	20	15	20	0	0.646	1.000	1.000
474	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ARHGAP1(1), ARHGEF11(3), BTK(2), INPPL1(1), ITPR1(4), ITPR2(7), ITPR3(5), LIMK1(1), MYLK(6), MYLK2(2), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3CG(3), PIK3R1(2), PITX2(1), PTEN(5), ROCK2(2), SAG(1), WASL(1)	44690193	65	63	65	26	3	11	23	19	9	0	0.892	1.000	1.000
475	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	BRAF(2), DAG1(3), DRD2(2), EGFR(6), EPHB2(2), GRB2(2), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), KCNJ9(1), PIK3CB(5), PITX2(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), RGS20(1), SHC1(1), SOS1(4), SOS2(1), SRC(1), STAT3(1)	37706814	67	62	67	20	5	12	30	15	5	0	0.572	1.000	1.000
476	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CTLA4(1), DAG1(3), EPHB2(2), FBXW7(5), GRB2(2), ITK(7), ITPKB(4), LCK(1), LCP2(1), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PAK1(1), PAK2(2), PAK3(5), PAK6(2), PAK7(2), PLCG1(2), PTPRC(3), RASGRP1(1), RASGRP3(2), SOS1(4), SOS2(1), VAV1(3), ZAP70(1)	34871862	66	61	66	20	9	11	31	9	6	0	0.607	1.000	1.000
477	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(3), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOC2(4), AOC3(2), AOX1(5), CAT(1), CYP1A1(2), CYP1A2(2), CYP2A13(2), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2J2(1), CYP4F8(1), CYP51A1(1), DDC(2), EHHADH(2), GCDH(1), HAAO(1), HADHA(1), KMO(2), KYNU(1), MAOA(2), MAOB(1), SDS(1), WARS(2), WARS2(1)	35934903	67	61	67	23	4	13	23	18	9	0	0.679	1.000	1.000
478	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	63	CASP9(2), CHP(1), KDR(7), MAPK14(2), NFAT5(4), NFATC1(1), NFATC2(3), NFATC4(2), NOS3(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCG1(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(2), PRKCG(2), PTGS2(1), PTK2(2), PXN(2), SH2D2A(1), SRC(1), VEGFA(1)	42116108	65	60	65	22	8	12	19	19	7	0	0.619	1.000	1.000
479	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(8), CCNA1(2), CCNG2(1), CCNH(1), CDC25A(1), CDKN1A(1), CDKN1B(1), CDKN2C(2), CREB3(1), CREB3L1(1), CREB3L4(1), E2F2(2), E2F3(1), E2F4(1), E2F5(3), GBA2(3), MCM2(3), MCM3(1), MCM4(2), MCM5(1), MCM6(1), MNAT1(1), MYT1(1), NACA(3), ORC1L(2), ORC2L(2), POLA2(1), POLE(2), POLE2(2), RBL1(1), RPA1(2), RPA2(1), TFDP1(3), TNXB(3)	46814142	62	59	62	22	12	8	20	10	12	0	0.790	1.000	1.000
480	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA2(1), INPP1(1), INPP4B(2), INPP5B(2), INPPL1(1), IPMK(1), ISYNA1(1), ITPK1(1), ITPKB(4), MIOX(1), OCRL(1), PI4KB(5), PIK3C3(2), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIP4K2A(1), PIP4K2B(1), PIP5K1A(1), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCD4(3), PLCE1(1), PLCG1(2), PLCG2(1), PLCZ1(1), PTEN(5), SYNJ1(6)	45429948	72	59	72	18	5	15	28	20	4	0	0.288	1.000	1.000
481	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	62	CDS1(1), CHKA(1), CRLS1(2), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), DGKI(4), ETNK1(1), ETNK2(3), GNPAT(6), GPAM(2), GPD2(2), LYPLA2(1), MYST3(5), MYST4(6), PLA2G2F(1), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLD1(2), PLD2(2), PPAP2A(2), PTDSS1(1), PTDSS2(1), SH3GLB1(1)	41236102	60	57	60	22	6	8	25	15	6	0	0.858	1.000	1.000
482	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(11), AR(4), BRAF(2), CCL15(3), DAG1(3), EGFR(6), GNA11(1), GNAQ(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), KCNJ9(1), MAPK14(2), PHKA2(2), PIK3CA(3), PIK3CD(2), PIK3R1(2), PITX2(1), SRC(1)	34010065	65	57	65	19	4	10	22	20	9	0	0.648	1.000	1.000
483	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(11), AXIN1(1), CSNK1E(1), CTNNB1(2), DVL3(1), FBXW2(1), FZD1(1), FZD3(1), FZD5(2), FZD7(2), LDLR(5), MAPK9(1), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCA(2), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(2), PRKCZ(2), PRKD1(3), RHOA(3), WNT11(2), WNT16(3), WNT2(1), WNT2B(3), WNT4(1), WNT6(2), WNT7A(3)	35361621	65	57	64	20	12	11	23	10	9	0	0.462	1.000	1.000
484	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	ABP1(3), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), AOX1(5), CARM1(3), CAT(1), CYP1A1(2), CYP1A2(2), CYP1B1(1), DDC(2), EHHADH(2), GCDH(1), HAAO(1), HADHA(1), HSD17B4(1), KMO(2), KYNU(1), LNX1(1), MAOA(2), MAOB(1), NFX1(2), OGDH(3), PRMT2(2), PRMT5(2), PRMT8(2), TPH2(2), WARS(2), WARS2(1)	39194801	66	56	66	18	6	11	25	17	7	0	0.359	1.000	1.000
485	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), CALM2(1), CALM3(1), CALR(1), CAMK4(4), CREBBP(11), F2(3), FGF2(1), MAPK14(2), MAPK8(1), MEF2C(1), MYH2(9), NFATC1(1), NFATC2(3), NFATC4(2), NPPA(1), PIK3CA(3), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1)	31569744	56	56	56	19	8	7	15	16	10	0	0.770	1.000	1.000
486	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	83	AK3(2), CAD(6), CANT1(1), CDA(1), CTPS2(2), DCK(1), DCTD(1), DPYD(2), DPYS(1), ENTPD1(2), ENTPD3(1), ENTPD5(1), ITPA(1), NT5C1A(1), NT5C1B(1), NT5C3(1), NT5E(2), POLA1(2), POLA2(1), POLD2(3), POLD3(1), POLE(2), POLE2(2), POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3A(1), POLR3B(1), RFC5(1), RRM1(1), RRM2B(2), TK2(1), TXNRD2(3), UCK2(1), UPB1(2)	52497193	59	55	59	27	12	4	17	18	8	0	0.954	1.000	1.000
487	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AKR1C1(2), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), CYP1A1(2), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2E1(1), CYP3A43(1), EPHX1(4), GSTA1(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTM4(1), GSTO2(1), MGST2(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1)	36881447	64	53	64	18	4	8	27	15	10	0	0.397	1.000	1.000
488	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(4), AR(4), ESR1(1), ESR2(2), HNF4A(2), NR1D2(1), NR1H3(5), NR1I2(1), NR1I3(1), NR2F1(2), NR2F2(1), NR3C1(2), NR4A2(3), NR5A2(1), PGR(1), PPARA(1), PPARD(3), RARA(1), RARB(1), RARG(2), ROR1(5), RORA(1), RORC(3), RXRA(2), RXRB(2), RXRG(1), VDR(1)	26291599	54	51	54	16	12	6	18	11	7	0	0.419	1.000	1.000
489	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	BCR(4), BTK(2), CD19(2), DAG1(3), EPHB2(2), GRB2(2), ITPKB(4), LYN(2), NFAT5(4), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PLCG2(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(1), VAV1(3)	31963451	52	49	52	19	4	9	26	7	6	0	0.864	1.000	1.000
490	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	BRD4(2), CAP1(1), F2RL2(1), GRB2(2), GSK3A(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS4(8), LNPEP(2), PARD3(1), PARD6A(1), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), PPYR1(1), PTEN(5), RPS6KA1(1), RPS6KA2(1), SHC1(1), SORBS1(1), SOS1(4), SOS2(1), YWHAB(1), YWHAE(2), YWHAG(1)	37037073	51	48	51	29	5	8	20	7	11	0	0.999	1.000	1.000
491	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(4), BTK(2), CD19(2), ITPR1(4), ITPR2(7), ITPR3(5), LYN(2), PDK1(1), PIK3CA(3), PITX2(1), PLCG2(1), PREX1(6), PTEN(5), PTPRC(3), RPS6KA1(1), RPS6KA2(1), SAG(1), VAV1(3)	35806809	52	48	52	17	2	7	21	14	8	0	0.783	1.000	1.000
492	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(2), CPEB1(1), EGFR(6), ERBB2(5), ERBB4(2), ETS1(1), ETS2(1), ETV6(1), ETV7(1), FMN2(2), GRB2(2), NOTCH2(5), NOTCH3(3), NOTCH4(9), PIWIL1(2), PIWIL2(1), PIWIL3(3), SOS1(4), SOS2(1), SPIRE1(2)	30470592	54	47	53	16	4	8	31	7	4	0	0.668	1.000	1.000
493	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(2), BCL2L2(1), CASP1(3), CASP4(1), CASP6(2), CASP7(1), CASP8(2), CASP9(2), CD40(1), DAXX(3), DFFB(1), FADD(1), IKBKE(2), LTA(1), NFKB1(2), NFKBIA(2), NGFR(2), NR3C1(2), NTRK1(2), PTPN13(5), SFRS2IP(2), TNF(1), TNFRSF1A(2), TRAF1(3), TRAF2(1), TRAF3(1), TRAF6(2)	28423524	50	46	50	15	5	8	17	11	9	0	0.633	1.000	1.000
494	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	45	ACCN1(2), ADCY4(1), ADCY6(1), ADCY8(2), CACNA1A(5), CACNA1B(2), GNAS(3), GNAT3(1), GRM4(2), ITPR3(5), PDE1A(1), PLCB2(3), PRKACA(1), PRKACB(1), PRKACG(1), SCNN1A(1), SCNN1B(1), SCNN1G(2), TAS1R1(1), TAS1R2(2), TAS2R16(2), TAS2R42(2), TAS2R43(1), TAS2R46(1), TAS2R50(2), TAS2R8(3), TAS2R9(1)	34321052	50	46	49	15	5	7	18	14	6	0	0.462	1.000	1.000
495	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(1), CDH1(2), CTNNB1(2), CTTN(1), EZR(1), LY96(1), NCK2(1), PRKCA(2), RHOA(3), ROCK2(2), TLR4(5), TLR5(3), TUBA1B(1), TUBA3C(4), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2C(1), TUBB3(3), TUBB4(2), TUBB4Q(1), TUBB8(2), WAS(2), WASL(1)	32772810	51	46	51	17	8	7	18	14	4	0	0.598	1.000	1.000
496	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(1), ACTB(1), ACTG1(1), ARHGEF2(1), CDH1(2), CTNNB1(2), CTTN(1), EZR(1), LY96(1), NCK2(1), PRKCA(2), RHOA(3), ROCK2(2), TLR4(5), TLR5(3), TUBA1B(1), TUBA3C(4), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2C(1), TUBB3(3), TUBB4(2), TUBB4Q(1), TUBB8(2), WAS(2), WASL(1)	32772810	51	46	51	17	8	7	18	14	4	0	0.598	1.000	1.000
497	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	AGPS(1), CDS1(1), CHKA(1), CPT1B(5), DGKA(2), DGKB(3), DGKD(2), DGKG(1), DGKH(4), ETNK1(1), GNPAT(6), GPD2(2), LYPLA2(1), PAFAH2(2), PLA2G3(1), PLA2G4A(1), PLA2G5(1), PLA2G6(1), PLCB2(3), PLCG1(2), PLCG2(1), PPAP2A(2)	30518418	44	44	44	13	4	8	16	12	4	0	0.525	1.000	1.000
498	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	53	AK3(2), CAD(6), CANT1(1), CDA(1), CTPS2(2), DCK(1), DCTD(1), DPYD(2), DPYS(1), ENTPD1(2), ITPA(1), NT5E(2), POLB(2), POLD2(3), POLE(2), POLG(2), POLQ(3), POLR2B(4), POLR2C(1), POLR2H(1), RRM1(1), TK2(1), UCK2(1), UNG(1), UPB1(2)	36134202	46	44	46	18	8	6	16	10	6	0	0.851	1.000	1.000
499	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	ATF1(2), BRAF(2), CREB3(1), CREBBP(11), DAG1(3), EGR1(2), EGR2(2), ELK1(2), GNAQ(1), MAP1B(1), MAP2K4(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), NTRK1(2), OPN1LW(3), PIK3C2G(2), PIK3CA(3), PIK3CD(2), PIK3R1(2), PTPN11(1), SHC1(1), SRC(1)	29961760	49	44	49	23	3	5	19	13	9	0	0.984	1.000	1.000
500	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CALM3(1), CD3E(2), CD3G(1), ELK1(2), FOS(1), GRB2(2), LCK(1), MAP2K4(2), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKCA(2), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(3), ZAP70(1)	30425225	49	44	49	18	6	6	22	9	6	0	0.861	1.000	1.000
501	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(6), ARHGEF11(3), ARHGEF5(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), DIAPH1(1), GSN(3), LIMK1(1), MYL2(1), MYLK(6), OPHN1(2), PIP5K1A(1), PPP1R12B(3), SRC(1), VCL(6)	29278267	44	43	44	14	5	8	18	11	2	0	0.578	1.000	1.000
502	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	DAG1(3), DGKA(2), ETFA(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), NR1I3(1), PAK1(1), PDE3A(3), PDE3B(1), PIK3C2G(2), PIK3CA(3), PIK3CD(2), PIK3R1(2), PSME1(2), RIPK3(2), VASP(1)	31282624	46	43	46	19	2	7	17	13	7	0	0.932	1.000	1.000
503	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	ARHGEF11(3), DLG4(1), LPA(7), MAP2K4(2), MAP3K1(2), MAP3K5(5), MAPK8(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PDK1(1), PHKA2(2), PIK3CB(5), PLD1(2), PLD2(2), PTK2(2), ROCK2(2), SERPINA4(3), SRF(1)	30995585	48	43	48	16	8	7	15	8	10	0	0.787	1.000	1.000
504	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(1), ADH1B(1), ADH1C(1), ADH5(2), ADH6(1), ADHFE1(1), AKR1A1(2), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), G6PC2(1), GAPDH(1), GCK(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), PFKM(1), PFKP(2), PGK1(1), PGK2(1), PKLR(1)	36491823	44	42	44	15	7	8	15	10	4	0	0.508	1.000	1.000
505	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(1), ELK1(2), FOS(1), GRB2(2), HGF(2), ITGA1(2), MAP4K1(2), MAPK8(1), MET(4), PAK1(1), PIK3CA(3), PIK3R1(2), PTEN(5), PTK2(2), PTK2B(3), PTPN11(1), PXN(2), RASA1(2), SOS1(4), SRC(1), STAT3(1)	28963535	45	42	45	18	3	5	22	5	10	0	0.957	1.000	1.000
506	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	109	ATP12A(3), ATP4A(1), ATP5A1(1), ATP5C1(1), ATP5E(1), ATP5G2(1), ATP5G3(1), ATP5J2(1), ATP5O(1), ATP6AP1(3), ATP6V0A2(2), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), COX10(1), COX15(1), COX6B1(1), COX8C(1), CYC1(2), NDUFA9(1), NDUFB2(1), NDUFB5(1), NDUFB9(1), NDUFS1(1), NDUFV1(1), NDUFV3(2), PPA2(1), SDHA(1), SDHC(1), UQCRB(1)	35950485	41	41	40	14	8	5	11	11	6	0	0.700	1.000	1.000
507	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	DAG1(3), GNAQ(1), ITPKB(4), ITPR1(4), ITPR2(7), ITPR3(5), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PDK1(1), PHKA2(2), PIK3CB(5), PITX2(1), PLD1(2), PLD2(2), VN1R1(1)	27599153	45	40	45	14	3	6	16	12	8	0	0.748	1.000	1.000
508	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(2), CALM2(1), CALM3(1), ELK1(2), FOS(1), GRB2(2), LYN(2), MAP2K4(2), MAP3K1(2), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(2), PAK2(2), PIK3CA(3), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(1), PPP3CC(1), SHC1(1), SOS1(4), VAV1(3)	27064842	42	39	42	16	4	7	20	8	3	0	0.871	1.000	1.000
509	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(1), INPP4B(2), INPPL1(1), ITPKB(4), MIOX(1), OCRL(1), PIK3C2A(1), PIK3C2B(1), PIK3C2G(2), PIK3CA(3), PIK3CB(5), PIK3CG(3), PLCB1(6), PLCB2(3), PLCB3(2), PLCB4(3), PLCG1(2), PLCG2(1)	28813963	42	39	42	15	4	8	17	12	1	0	0.767	1.000	1.000
510	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(3), LIMK1(1), MAP3K1(2), MYL2(1), MYLK(6), NCF2(6), PAK1(1), PDGFRA(2), PIK3CA(3), PIK3R1(2), PLD1(2), PPP1R12B(3), TRIO(6), VAV1(3)	23204181	41	39	41	17	2	2	16	16	5	0	0.959	1.000	1.000
511	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(11), DAG1(3), DLG4(1), EPHB2(2), GNAQ(1), ITPR1(4), ITPR2(7), ITPR3(5), KCNJ9(1), PITX2(1), RYR1(11)	29882080	47	39	47	18	5	6	17	16	3	0	0.857	1.000	1.000
512	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	40	ABP1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AMD1(1), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(1), CPS1(6), GATM(1), GLUD1(1), GOT1(1), MAOA(2), MAOB(1), NOS1(2), NOS3(2), ODC1(2), OTC(1), RARS(1)	27048647	41	38	41	18	2	6	12	11	10	0	0.951	1.000	1.000
513	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	90	ANK2(10), B3GALT4(1), DGKI(4), IL6ST(1), PIGK(1), RPL14(1), RPL15(1), RPL22(1), RPL30(1), RPL32(1), RPL8(1), RPLP1(1), RPS10(2), RPS14(1), RPS27A(1), RPS3(1), RPS6(1), RPS6KA1(1), RPS6KA2(1), RPS6KB2(1), RPS9(1), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBA52(1), UBC(2)	31856198	41	38	41	18	7	6	11	8	9	0	0.944	1.000	1.000
514	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B4(2), EIF2B5(7), EIF2S1(1), EIF2S2(1), FLT1(3), FLT4(1), KDR(7), NOS3(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(2), PXN(2), SHC1(1)	20807128	38	38	38	13	7	8	8	9	6	0	0.672	1.000	1.000
515	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CALM3(1), ELK1(2), FPR1(1), MAP2K6(1), MAP3K1(2), MAPK14(2), NCF2(6), NFATC1(1), NFATC2(3), NFATC4(2), NFKB1(2), NFKBIA(2), PAK1(1), PIK3C2G(2), PLCB1(6), PPP3CA(1), PPP3CC(1), RELA(1)	24296664	38	37	38	16	6	4	14	11	3	0	0.915	1.000	1.000
516	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), GAPDH(1), GCK(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), PFKM(1), PFKP(2), PGK1(1), PKLR(1)	31611732	39	37	39	16	7	9	13	7	3	0	0.689	1.000	1.000
517	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), GAPDH(1), GCK(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), PFKM(1), PFKP(2), PGK1(1), PKLR(1)	31611732	39	37	39	16	7	9	13	7	3	0	0.689	1.000	1.000
518	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), ALAS2(1), COX10(1), COX15(1), CP(1), EPRS(1), FTH1(1), FTMT(1), GUSB(2), HMBS(1), HMOX2(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(2), UGT1A7(1), UGT1A8(2), UGT1A9(3), UGT2A1(2), UGT2A3(3), UGT2B10(2), UGT2B11(2), UGT2B28(1), UGT2B4(1), UGT2B7(1), UROD(1), UROS(1)	26720642	38	37	38	11	4	6	12	10	6	0	0.533	1.000	1.000
519	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	ANKHD1(1), EEF1D(1), EEF1G(1), EEF2K(1), EIF1AX(1), EIF2AK2(2), EIF2AK3(3), EIF2B4(2), EIF2B5(7), EIF2S1(1), EIF2S2(1), EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G3(2), EIF5B(1), ETF1(1), GSPT2(1), KIAA0664(1), PABPC1(1), PABPC3(4), PAIP1(1)	26667583	38	37	38	11	3	3	16	9	7	0	0.679	1.000	1.000
520	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGTR2(2), CALM2(1), CALM3(1), CAMK2B(1), CAMK2D(2), F2(3), GNA11(1), GRB2(2), JAK2(1), MAPK14(2), MAPK8(1), MYLK(6), PLCG1(2), PRKCA(2), PTK2B(3), SHC1(1), SOS1(4), STAT1(2), STAT3(1)	27026196	38	36	38	11	6	5	15	10	2	0	0.493	1.000	1.000
521	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(4), ELK1(2), FOS(1), GRB2(2), LYN(2), MAP3K1(2), PAPPA(4), RPS6KA1(1), SHC1(1), SOS1(4), VAV1(3), VAV2(4), VAV3(5)	18826526	37	36	37	12	2	3	20	8	4	0	0.827	1.000	1.000
522	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(2), EGFR(6), ELK1(2), FOS(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK8(1), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(2), STAT3(1)	24448105	38	35	38	12	3	5	20	6	4	0	0.744	1.000	1.000
523	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACB(8), ACAT1(3), ACAT2(1), ACOT12(1), ACSS1(1), AKR1B1(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), DLAT(1), GLO1(1), HAGH(1), LDHA(1), LDHB(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PC(1), PCK2(1), PKLR(1)	30504111	39	35	39	19	5	9	13	8	4	0	0.931	1.000	1.000
524	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN2(7), ACTN3(2), BCR(4), GRB2(2), ITGA1(2), MAPK8(1), PPP1R12B(3), PTK2(2), PXN(2), SHC1(1), SOS1(4), SRC(1), VCL(6)	29273436	38	35	37	11	5	4	21	4	4	0	0.582	1.000	1.000
525	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	ATF2(2), CALM2(1), CALM3(1), EGFR(6), ELK1(2), GNAQ(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK8(1), MEF2A(1), MEF2C(1), MEF2D(1), PAK1(1), PRKCA(2), PTK2(2), PTK2B(3), SHC1(1), SOS1(4), SRC(1)	22028249	37	34	37	14	2	6	19	4	6	0	0.870	1.000	1.000
526	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(6), ELK1(2), GNAS(3), GRB2(2), IGF1R(1), KLK2(1), MKNK1(2), NGFR(2), PDGFRA(2), PPP2CA(2), PTPRR(3), RPS6KA1(1), RPS6KA5(2), SHC1(1), SOS1(4), SRC(1), STAT3(1)	21136553	36	34	35	17	1	5	19	6	5	0	0.958	1.000	1.000
527	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ADCY3(2), ADCY9(4), AK1(1), ARF5(2), ARL4D(1), ATP6V0A2(2), ATP6V0A4(1), ATP6V1C2(3), ATP6V1D(1), ATP6V1E2(1), ATP6V1F(1), ERO1L(2), GNAS(3), PDIA4(1), PLCG1(2), PLCG2(1), PRKCA(2), SEC61A1(1), SEC61A2(1), TRIM23(3)	23821392	36	34	34	15	7	3	10	9	7	0	0.825	1.000	1.000
528	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(2), CALM2(1), CALM3(1), CD79A(1), ELK1(2), FOS(1), GRB2(2), LYN(2), MAP3K1(2), MAPK14(2), MAPK8(1), NFATC1(1), NFATC2(3), NFATC4(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKCA(2), SHC1(1), SOS1(4), VAV1(3)	24425089	37	33	37	13	7	5	15	8	2	0	0.705	1.000	1.000
529	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(3), ACADM(3), ACADSB(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOC2(4), AOC3(2), DPYD(2), DPYS(1), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), SDS(1), UPB1(2)	19061251	33	33	33	14	2	6	7	9	9	0	0.884	1.000	1.000
530	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(1), AARS2(2), ADSL(1), ADSS(1), ADSSL1(1), AGXT2(3), ASL(1), ASNS(2), ASPA(1), ASS1(1), CAD(6), CRAT(1), DARS(2), DDO(3), DLAT(1), GAD1(1), GAD2(2), GOT1(1), NARS2(2), PC(1)	23922480	34	33	34	16	5	3	13	8	5	0	0.961	1.000	1.000
531	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(2), COL4A3(1), COL4A4(7), COL4A5(7), COL4A6(5), SLC23A2(3), SLC2A1(2), SLC2A3(2)	16229497	34	33	34	12	3	7	12	7	5	0	0.650	1.000	1.000
532	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	CARM1(3), CREBBP(11), EP300(2), ERCC3(1), ESR1(1), GTF2E1(1), HDAC1(1), HDAC3(2), HDAC4(1), HDAC5(1), HDAC6(3), MEF2C(1), NCOR2(3), NRIP1(2), PELP1(1), TBP(1)	25876198	35	32	35	14	2	6	11	5	11	0	0.891	1.000	1.000
533	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACPP(2), ALPI(2), ALPL(2), ALPP(2), CYP1A1(2), CYP1A2(2), CYP2A13(2), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(4), CYP2C9(1), CYP2D6(1), CYP2E1(1), CYP2J2(1), CYP4F8(1), CYP51A1(1)	18530817	33	32	33	13	4	7	14	6	2	0	0.692	1.000	1.000
534	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	BRAF(2), CAB39(1), FIGF(1), PDPK1(1), PGF(1), PIK3CA(3), PIK3CB(5), PIK3CD(2), PIK3CG(3), PIK3R1(2), PIK3R2(1), PIK3R5(2), PRKAA2(2), RHEB(1), RICTOR(1), RPS6(1), RPS6KA1(1), RPS6KA2(1), RPS6KB2(1), TSC2(3), VEGFA(1)	30700258	36	32	36	21	1	4	9	17	5	0	0.996	1.000	1.000
535	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), CAMK2B(1), CAMK2D(2), GNAS(3), GRB2(2), MAPK14(2), PIK3CA(3), PIK3R1(2), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2), RPS6KA1(1), RPS6KA5(2), SOS1(4)	18119931	33	31	32	12	7	4	9	7	6	0	0.795	1.000	1.000
536	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	23	CAD(6), CPS1(6), EPRS(1), GAD1(1), GAD2(2), GCLM(1), GLS(1), GLS2(2), GLUD1(1), GLUL(1), GMPS(3), GOT1(1), GSS(3), NADSYN1(2), PPAT(2), QARS(2)	21640842	35	31	35	11	4	3	13	9	6	0	0.668	1.000	1.000
537	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(1), ALDOB(1), ALDOC(1), DLAT(1), ENO2(1), ENO3(1), G6PC(1), GAPDH(1), GCK(1), GOT1(1), GPI(2), HK1(1), HK2(2), HK3(4), LDHA(1), LDHB(1), MDH1(1), MDH2(2), PC(1), PDHX(1), PFKM(1), PFKP(2), PGK1(1), PGK2(1), PKLR(1)	26194647	32	31	32	14	8	4	12	5	3	0	0.813	1.000	1.000
538	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(3), GPRC5B(2), GPRC5C(2), GRM1(4), GRM3(2), GRM4(2), GRM5(2), GRM7(4), GRM8(5)	13332503	32	31	32	11	9	2	13	6	2	0	0.642	1.000	1.000
539	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(1), ACADM(3), ACADS(1), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOX1(5), BCAT2(2), EHHADH(2), HADHA(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC2(1), OXCT1(2), PCCA(2), PCCB(1)	28537712	36	31	36	14	1	6	11	11	7	0	0.876	1.000	1.000
540	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(3), ACADM(3), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), DPYD(2), DPYS(1), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), UPB1(2)	17530878	31	31	31	12	2	4	7	10	8	0	0.837	1.000	1.000
541	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), ACADS(1), ACAT1(3), ACAT2(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), BDH1(1), DDHD1(1), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), HMGCS2(1), HSD17B4(1), HSD3B7(1), ILVBL(1), L2HGDH(2), OXCT1(2), PLA1A(1), RDH11(1), RDH12(1), RDH13(1), RDH14(1)	26684335	36	31	36	16	1	6	13	10	6	0	0.925	1.000	1.000
542	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(3), EIF4G3(2), IRS1(3), MAPK14(2), MKNK1(2), PABPC1(1), PDPK1(1), PIK3CA(3), PIK3R1(2), PRKCA(2), PTEN(5)	18195158	31	30	31	18	2	2	11	7	9	0	0.999	1.000	1.000
543	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CALM2(1), CALM3(1), ELK1(2), FOS(1), GNAQ(1), GNAS(3), NFATC1(1), NFATC2(3), NFATC4(2), PLCG1(2), PPP3CA(1), PPP3CC(1), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PRKCA(2)	21392005	30	30	29	11	8	2	8	7	5	0	0.730	1.000	1.000
544	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK8(1), PDGFRA(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(2), STAT3(1)	22481596	34	30	34	13	3	4	17	7	3	0	0.879	1.000	1.000
545	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	GRB2(2), GSK3A(1), IL4R(1), IRS1(3), JAK3(4), MAP4K1(2), PDK1(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), SHC1(1), SOS1(4), SOS2(1), STAT6(4)	22113882	31	30	31	17	3	5	14	5	4	0	0.982	1.000	1.000
546	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	BTK(2), GRB2(2), GSK3A(1), IGFBP1(1), INPP5D(4), PDK1(1), PIK3CA(3), PTEN(5), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(4), SOS2(1), YWHAB(1), YWHAE(2), YWHAG(1)	23347010	31	30	31	15	1	7	15	3	5	0	0.966	1.000	1.000
547	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GRB2(2), INSR(5), IRS1(3), JAK2(1), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), RPS6KA1(1), SHC1(1), SOS1(4), SRF(1), STAT5B(3)	21023180	31	29	31	14	2	3	16	6	4	0	0.947	1.000	1.000
548	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	CABIN1(2), CALM2(1), CALM3(1), HDAC5(1), IGF1R(1), INSR(5), MAP2K6(1), MAPK14(2), MAPK7(2), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(1), NFATC1(1), NFATC2(3), PIK3CA(3), PIK3R1(2), PPP3CA(1), PPP3CC(1)	21006444	31	29	31	17	5	2	12	9	3	0	0.985	1.000	1.000
549	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	27	DUSP1(1), GORASP1(2), MAP2K4(2), MAPK14(2), MAPK8(1), MAPK8IP1(1), MAPK9(1), MAPKAPK5(1), NFKB1(2), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL2(1), PIK3CA(3), PIK3CD(2), PIK3R1(2), TRAF2(1), TRAF3(1), TRAF5(1), TRAF6(2)	17452428	30	29	30	10	5	5	9	6	5	0	0.761	1.000	1.000
550	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	GRB2(2), IL4R(1), INPP5D(4), JAK2(1), JAK3(4), PIK3CA(3), SERPINA4(3), SHC1(1), SOS1(4), SOS2(1), SRC(1), STAT6(4), TYK2(2)	23605763	31	29	31	15	2	6	14	6	3	0	0.936	1.000	1.000
551	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADM(3), ACADS(1), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), AOX1(5), EHHADH(2), HADHA(1), IVD(1), MCCC2(1), OXCT1(2), PCCA(2), PCCB(1), SDS(1)	23788626	34	29	34	14	1	8	10	9	6	0	0.898	1.000	1.000
552	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACB(8), ACADM(3), ACAT1(3), ACAT2(1), ACSS1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), ALDH7A1(1), EHHADH(2), HADHA(1), LDHA(1), LDHB(1), PCCA(2), PCCB(1)	26567086	32	28	32	13	3	7	12	6	4	0	0.863	1.000	1.000
553	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), INSR(5), IRS1(3), MAPK8(1), PIK3CA(3), PIK3R1(2), PTPN11(1), RASA1(2), SHC1(1), SOS1(4), SRF(1)	16081531	30	28	30	14	0	4	16	8	2	0	0.968	1.000	1.000
554	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CXCR3(3), EGFR(6), ITGA1(2), MYL2(1), MYLK(6), PRKACB(1), PRKACG(1), PRKAR1B(1), PRKAR2A(2), PRKAR2B(1), PTK2(2), PXN(2)	21471244	29	28	29	11	4	2	9	7	7	0	0.807	1.000	1.000
555	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A1(1), EIF4A2(2), EIF4G1(2), EIF4G2(3), EIF4G3(2), MKNK1(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), PTEN(5), RPS6(1), TSC2(3)	16789905	29	28	29	15	0	2	12	6	9	0	0.994	1.000	1.000
556	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACAT1(3), ACAT2(1), ADH5(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), DLAT(1), GLO1(1), HAGH(1), LDHA(1), LDHB(1), MDH1(1), MDH2(2), ME1(2), ME3(1), PC(1), PKLR(1)	23781816	30	27	30	18	2	8	11	6	3	0	0.986	1.000	1.000
557	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(1), ADSL(1), ADSS(1), AGXT2(3), ASL(1), ASNS(2), ASPA(1), CAD(6), CRAT(1), DARS(2), DDO(3), GAD1(1), GAD2(2), GOT1(1), PC(1)	16407868	27	26	27	12	3	3	10	6	5	0	0.943	1.000	1.000
558	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), DIAPH1(1), GSN(3), ITGA1(2), MYL2(1), MYLK(6), PIK3CA(3), PIK3R1(2), PTK2(2), PXN(2), SHC1(1), SRC(1)	24731477	26	26	26	15	2	5	8	6	5	0	0.983	1.000	1.000
559	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(2), CA1(2), CA12(1), CA14(1), CA3(1), CA4(2), CA5A(1), CA6(2), CA9(3), CPS1(6), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUD2(3), GLUL(1), HAL(1)	13972218	31	26	31	10	0	6	10	9	6	0	0.671	1.000	1.000
560	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(2), DLG4(1), EPHB2(2), F2(3), F2RL2(1), MAPK7(2), MAPK8(1), MYEF2(1), PLD1(2), PLD2(2), PTK2(2), RASAL1(4), SRC(1), VAV1(3)	17614850	27	26	27	15	4	4	9	5	5	0	0.981	1.000	1.000
561	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(5), GNAQ(1), GNAS(3), LIMK1(1), MYL2(1), PIK3C2G(2), PLCB1(6), PPP1R12B(3), PRKCA(2), PTK2(2), ROCK2(2)	16398616	28	25	27	11	2	3	11	7	5	0	0.879	1.000	1.000
562	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(2), CD3G(1), CD80(2), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(1), ITK(7), LCK(1), PIK3CA(3), PIK3R1(2), PTPN11(1)	8517718	25	25	25	10	0	4	13	5	3	0	0.889	1.000	1.000
563	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	31	ARG1(1), ARG2(1), ASL(1), ASS1(1), CPS1(6), EPRS(1), GATM(1), GLUD1(1), GLUD2(3), GOT1(1), NOS1(2), NOS3(2), OTC(1), PARS2(1), RARS(1), RARS2(3)	21645723	27	25	27	14	0	3	10	8	6	0	0.982	1.000	1.000
564	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(1), POLB(2), POLD2(3), POLD3(1), POLE(2), POLE2(2), POLG(2), POLI(2), POLK(1), POLM(2), POLQ(3), REV3L(1), RFC5(1)	27381923	25	25	25	12	3	3	11	6	2	0	0.968	1.000	1.000
565	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(7), EIF2S1(1), EIF2S2(1), IGF1R(1), INPPL1(1), PDPK1(1), PIK3CA(3), PIK3R1(2), PPP2CA(2), PTEN(5), RPS6(1)	12780176	25	25	25	10	4	4	8	2	7	0	0.890	1.000	1.000
566	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CALM2(1), CALM3(1), GNAQ(1), GRB2(2), MAP2K4(2), MAP3K1(2), MAPK14(2), MAPK8(1), PAK1(1), PLCG1(2), PRKCA(2), PTK2B(3), SHC1(1), SOS1(4), SRC(1)	17912685	26	25	26	10	4	4	12	3	3	0	0.818	1.000	1.000
567	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(2), CREB3(1), DUSP9(2), EEF2K(1), GRB2(2), MKNK1(2), MOS(2), NFKB1(2), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(4), SOS2(1), TRAF3(1)	19017882	25	25	25	14	1	3	11	6	4	0	0.990	1.000	1.000
568	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), IGF1R(1), IRS1(3), MAPK8(1), PIK3CA(3), PIK3R1(2), PTPN11(1), RASA1(2), SHC1(1), SOS1(4), SRF(1)	15741621	26	24	26	12	0	4	14	6	2	0	0.960	1.000	1.000
569	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	FOS(1), GRB2(2), IL2RA(1), IL2RB(1), IRS1(3), JAK3(4), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(4), STAT5B(3)	22500082	25	24	25	15	1	5	12	4	3	0	0.984	1.000	1.000
570	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(2), CA12(1), CA14(1), CA3(1), CA4(2), CA5A(1), CA6(2), CA9(3), CPS1(6), CTH(1), GLS(1), GLS2(2), GLUD1(1), GLUL(1), HAL(1)	12570467	28	24	28	10	0	6	9	8	5	0	0.723	1.000	1.000
571	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1B(1), ADH1C(1), ADH6(1), ADHFE1(1), AKR1C4(2), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(1), SOAT2(2), SRD5A1(1), SRD5A2(1)	15231497	24	23	24	10	3	6	6	6	3	0	0.788	1.000	1.000
572	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACADS(1), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), EHHADH(2), GAD1(1), GAD2(2), HADHA(1), L2HGDH(2), OXCT1(2), SDS(1)	16962965	26	23	26	12	0	7	8	7	4	0	0.909	1.000	1.000
573	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCL12(1), GNAQ(1), NFKB1(2), PIK3C2G(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(2), PTK2B(3), PXN(2), RELA(1)	17746844	23	23	23	14	4	3	9	3	4	0	0.988	1.000	1.000
574	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	BPNT1(1), GRB2(2), PDK1(1), PIK3CA(3), PIK3CD(2), PTEN(5), PTK2B(3), RBL2(3), SHC1(1), SOS1(4)	12923986	25	23	25	10	1	4	14	3	3	0	0.924	1.000	1.000
575	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(3), ITGAV(2), PDGFRA(2), PIK3CA(3), PIK3R1(2), PLCB1(6), PRKCA(2), PTK2(2), SRC(1)	17620224	23	22	23	13	4	2	9	4	4	0	0.976	1.000	1.000
576	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACADM(3), ACADSB(1), ACAT1(3), ACAT2(1), ALDH1A1(1), ALDH1A3(1), ALDH1B1(1), ALDH2(1), ALDH3A1(2), ALDH3A2(2), EHHADH(2), HADHA(1), LDHA(1), LDHB(1), PCCA(2), PCCB(1), SDS(1)	22087867	25	22	25	13	1	7	9	4	4	0	0.974	1.000	1.000
577	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(1), GTF2B(2), GTF2E1(1), GTF2F2(1), GTF2H4(1), MNAT1(1), POLR1A(2), POLR2B(4), POLR2C(1), POLR2H(1), POLR3B(1), POLR3E(1), TAF12(1), TAF5(1), TAF6(1), TBP(1)	23046127	22	22	22	13	3	2	6	7	4	0	0.972	1.000	1.000
578	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(2), ELK1(2), FOS(1), GRB2(2), IL6R(1), IL6ST(1), JAK2(1), JAK3(4), PTPN11(1), SHC1(1), SOS1(4), SRF(1), STAT3(1)	15291163	22	20	22	10	2	3	9	7	1	0	0.891	1.000	1.000
579	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	CDKN1B(1), GRB2(2), PDPK1(1), PIK3CA(3), PIK3R1(2), PTEN(5), PTK2(2), SHC1(1), SOS1(4)	12087214	21	20	21	11	0	5	9	1	6	0	0.983	1.000	1.000
580	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(2), MAPK7(2), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(2), PIK3CA(3), PIK3R1(2), PLCG1(2), RPS6KA1(1), SHC1(1)	12092900	18	18	18	13	3	2	9	3	1	0	0.995	1.000	1.000
581	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	CDKN1A(1), ELK1(2), GRB2(2), NGFR(2), NTRK1(2), PIK3CA(3), PIK3CD(2), SHC1(1), SOS1(4)	9685330	19	18	19	13	2	3	12	2	0	0	0.991	1.000	1.000
582	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(2), KLK2(1), NTRK1(2), PIK3CA(3), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(1), SOS1(4)	10133327	19	18	19	12	3	4	9	1	2	0	0.982	1.000	1.000
583	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	MUSK(4), PIK3CA(3), PIK3R1(2), PTK2(2), PTK2B(3), RAPSN(1), SRC(1), TERT(1)	10081773	17	17	17	10	0	3	10	1	3	0	0.962	1.000	1.000
584	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(2), CHUK(1), ELK1(2), NFKB1(2), PIK3CA(3), PIK3R1(2), RALGDS(1), RELA(1), RHOA(3)	11920548	17	17	17	11	1	3	8	3	2	0	0.986	1.000	1.000
585	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(1), ARPC3(2), NCKAP1(3), NTRK1(2), PIR(1), WASF2(1), WASF3(1), WASL(1)	10132944	15	15	15	7	1	3	7	4	0	0	0.889	1.000	1.000
586	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(2), IGF1R(1), IRS1(3), PIK3CA(3), PIK3R1(2), SHC1(1), SOS1(4)	12024852	16	15	16	11	0	3	9	2	2	0	0.994	1.000	1.000
587	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CDKN1A(1), CDKN1B(1), NFKB1(2), NFKBIA(2), PAK1(1), PIK3CA(3), PIK3R1(2), RELA(1), TFDP1(3)	11721879	16	15	16	11	2	4	3	2	5	0	0.994	1.000	1.000
588	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(2), FOS(1), GRB2(2), JAK2(1), SHC1(1), SOS1(4), STAT5B(3)	10707081	14	14	14	5	0	2	10	2	0	0	0.784	1.000	1.000
589	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(2), PTK2B(3), SHC1(1), SOS1(4), SRC(1)	5687318	13	13	13	5	0	2	11	0	0	0	0.835	1.000	1.000
590	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K6(1), MAP3K1(2), MAPK14(2), NFKB1(2), PIK3CA(3), PIK3R1(2), RELA(1)	11384050	13	12	13	10	3	2	3	4	1	0	0.994	1.000	1.000
591	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(1), PTGS1(3), PTGS2(1)	3564865	8	8	8	4	3	1	4	0	0	0	0.797	1.000	1.000
592	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGEF2(1), COPA(1), GBF1(1), GPLD1(2), KDELR2(1), KDELR3(2)	10589657	9	8	9	4	0	2	3	4	0	0	0.872	1.000	1.000
593	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(2), FOS(1), MAPK14(2), THBS1(3)	4825034	8	8	8	4	1	0	3	4	0	0	0.915	1.000	1.000
594	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	12	AKR1A1(2), EHHADH(2), HADHA(1), HSD17B4(1), SIRT5(1)	7527684	7	7	7	5	0	0	5	2	0	0	0.974	1.000	1.000
595	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	9	ANPEP(2), FBL(1), LDHA(1), LDHB(1), MAPK14(2)	5604016	7	7	7	6	1	2	3	1	0	0	0.980	1.000	1.000
596	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	10	ALAS1(1), ALAS2(1), CPO(1), HMBS(1), UROD(1), UROS(1)	5369251	6	6	6	5	2	1	2	1	0	0	0.964	1.000	1.000
597	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B2(1), HSD17B4(1), HSD3B1(2), HSD3B2(1)	5369137	6	6	6	4	0	1	2	3	0	0	0.944	1.000	1.000
598	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(2), KLK2(1), NGFR(2)	4878141	5	5	5	4	1	1	3	0	0	0	0.935	1.000	1.000
599	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), ALAS2(1), HMBS(1), UROD(1), UROS(1)	5180064	5	5	5	4	2	1	1	1	0	0	0.945	1.000	1.000
600	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB1(1), PSMB4(2), PSMB6(1), PSMB9(1)	5736343	5	5	5	4	0	0	4	1	0	0	0.977	1.000	1.000
601	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), CASP8AP2(1), CASP9(2)	6995611	5	5	5	3	0	1	2	2	0	0	0.916	1.000	1.000
602	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL4R(1), JAK2(1), TYK2(2)	6693265	5	5	5	4	0	1	1	3	0	0	0.947	1.000	1.000
603	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL4R(1), JAK2(1), TYK2(2)	6693265	5	5	5	4	0	1	1	3	0	0	0.947	1.000	1.000
604	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK2(1), PTPRU(1), STAT1(2)	7472520	4	4	4	3	0	0	3	1	0	0	0.942	1.000	1.000
605	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK2(1), STAT1(2)	5455555	3	3	3	4	0	0	2	1	0	0	0.987	1.000	1.000
606	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), SNCAIP(1)	4105802	3	3	3	3	0	0	2	1	0	0	0.970	1.000	1.000
607	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS(1), LARS2(2)	6832386	3	3	3	5	0	1	2	0	0	0	0.995	1.000	1.000
608	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHKA(1), SLC18A3(1)	4391316	2	2	2	3	0	0	1	1	0	0	0.970	1.000	1.000
609	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), RDH5(1)	2616108	2	2	2	3	0	2	0	0	0	0	0.958	1.000	1.000
610	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYC(1)	3262376	1	1	1	2	0	0	1	0	0	0	0.989	1.000	1.000
611	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1)	4055727	1	1	1	3	0	0	1	0	0	0	0.996	1.000	1.000
612	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		1054432	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		501211	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		350506	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		1107523	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		1010478	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
