rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(5), CDKN2A(31), MDM2(2), PIK3CA(4), PIK3R1(1), POLR1A(3), POLR1B(3), RB1(3), TBX2(1), TP53(100)	4538065	153	108	113	4	28	21	21	25	58	0	6.45e-14	<1.00e-15	<1.23e-13
2	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(1), CDK4(2), CDKN2A(31), MDM2(2), NXT1(1), TP53(100)	1893625	138	106	98	2	28	17	17	21	55	0	1.99e-14	<1.00e-15	<1.23e-13
3	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(10), ATR(9), TP53(100), YWHAH(1)	3507307	120	105	92	5	27	14	16	23	40	0	4.56e-07	<1.00e-15	<1.23e-13
4	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(5), AKT1(1), ATM(10), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), MAPK8(2), MDM2(2), NFKBIB(1), TP53(100)	4637114	126	103	98	7	27	15	19	27	38	0	1.02e-08	<1.00e-15	<1.23e-13
5	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), NFKBIA(1), RELA(2), TP53(100)	2220923	106	101	78	2	25	13	13	21	34	0	3.12e-10	<1.00e-15	<1.23e-13
6	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(5), ATM(10), BRCA1(3), MAPK8(2), MDM2(2), MRE11A(2), NFKBIA(1), RAD50(1), RBBP8(3), RELA(2), TP53(100)	6591814	131	106	103	3	31	17	19	24	40	0	2.59e-11	1.67e-15	1.71e-13
7	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNGR1(2), IKBKB(4), JAK2(6), LIN7A(1), NFKBIA(1), RB1(3), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TP53(100), USH1C(2)	4102157	125	104	96	10	29	15	19	22	40	0	3.56e-07	2.22e-15	1.88e-13
8	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(10), ATR(9), BRCA1(3), CCNB1(1), CDC25A(1), CDC25B(1), CDC34(1), EP300(6), MDM2(2), MYT1(11), PRKDC(7), RPS6KA1(2), TP53(100), YWHAH(1)	9364724	155	109	127	11	37	20	21	32	45	0	2.20e-08	2.44e-15	1.88e-13
9	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(10), CDC25A(1), CDC25B(1), CDK4(2), MYT1(11), RB1(3), TP53(100), YWHAH(1)	3877709	129	104	101	5	32	16	19	25	37	0	1.90e-09	3.22e-15	1.98e-13
10	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(1), SP1(1), SP3(1), TP53(100)	1555114	103	102	75	0	25	12	13	19	34	0	7.99e-14	3.22e-15	1.98e-13
11	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(3), DAXX(3), HRAS(1), PML(3), RB1(3), SIRT1(1), SP100(3), TNFRSF1A(2), TNFRSF1B(1), TP53(100)	4264146	120	102	92	6	30	15	18	23	34	0	1.27e-09	3.55e-15	1.99e-13
12	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(3), ATM(10), BAD(1), CASP3(2), CASP7(1), CASP9(1), PTK2(10), PXN(1), STAT1(3), TLN1(12), TP53(100)	6076312	145	105	114	6	35	20	18	25	46	1	1.29e-10	4.00e-15	2.00e-13
13	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(10), ATR(9), BRCA1(3), BRCA2(7), FANCA(4), FANCC(1), FANCD2(5), FANCG(1), HUS1(1), MRE11A(2), RAD17(2), RAD50(1), TP53(100)	9672457	146	109	118	11	32	21	19	28	46	0	8.16e-07	4.33e-15	2.00e-13
14	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(5), ATM(10), ATR(9), CCNA1(3), CCNE1(1), CDC25A(1), CDK4(2), CDK6(2), CDKN2A(31), DHFR(1), GSK3B(2), RB1(3), SKP2(3), TFDP1(1), TGFB1(1), TP53(100)	6699802	175	111	135	14	31	26	26	28	64	0	1.34e-08	4.55e-15	2.00e-13
15	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(2), IGF1R(6), POLR2A(5), PPP2CA(1), RB1(3), TEP1(7), TERF1(1), TERT(5), TNKS(4), TP53(100), XRCC5(3)	6255053	138	106	110	12	40	17	16	26	39	0	2.80e-08	5.00e-15	2.05e-13
16	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(3), BAK1(1), BIRC2(2), CASP2(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), FASLG(1), MAP2K4(5), MAP3K1(3), MDM2(2), NFKBIA(1), PARP1(2), PRF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TP53(100), TRADD(1), TRAF2(2)	8357997	138	105	110	13	33	18	24	24	39	0	1.80e-07	6.11e-15	2.35e-13
17	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(3), ATM(10), CCNE1(1), CDK4(2), MDM2(2), RB1(3), TP53(100)	4021908	121	103	93	3	29	15	18	23	36	0	1.09e-10	6.55e-15	2.37e-13
18	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(35), C1R(1), C1S(6), C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2), MASP1(3)	4609907	75	47	42	7	9	7	8	7	44	0	0.0352	7.77e-15	2.66e-13
19	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(35), C1R(1), C1S(6), C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2), MASP1(3)	4732130	75	47	42	9	9	7	8	7	44	0	0.0934	8.55e-15	2.77e-13
20	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(35), C1R(1), C1S(6), C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2)	3891103	72	47	39	7	8	7	8	6	43	0	0.0589	8.99e-15	2.77e-13
21	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(3), BAD(1), BAK1(1), BIRC2(2), CASP1(1), CASP10(4), CASP2(3), CASP3(2), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FASLG(1), HELLS(1), IKBKB(4), IRF1(1), IRF2(1), IRF3(2), IRF5(1), IRF6(3), IRF7(2), MAP2K4(5), MAP3K1(3), MDM2(2), NFKBIA(1), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(2), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(2), TP53(100), TRADD(1), TRAF2(2)	12889076	167	110	139	17	39	26	27	27	48	0	2.72e-08	4.82e-13	1.41e-11
22	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), CDC42(1), DUSP10(2), GAB1(1), GCK(1), IL1R1(2), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K10(2), MAP3K12(4), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAP3K9(6), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(1), TP53(100), TRAF6(1)	11240716	156	104	126	16	40	21	22	28	45	0	3.52e-07	2.51e-12	7.02e-11
23	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), CDKN2A(31), E2F4(3)	2029082	44	32	32	4	2	8	7	5	22	0	0.00877	4.68e-12	1.25e-10
24	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(3), ATM(10), ATR(9), BAI1(5), CASP3(2), CASP8(2), CASP9(1), CCNB1(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(2), CDK4(2), CDK6(2), CDKN2A(31), DDB2(1), EI24(1), GTSE1(2), MDM2(2), MDM4(1), PERP(1), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(3), THBS1(3), TNFRSF10B(2), TP53(100), TSC2(6), ZMAT3(2)	14634920	216	115	176	26	50	36	28	30	72	0	3.45e-08	2.80e-11	7.19e-10
25	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(5), ATM(10), BUB1(3), BUB3(1), CCNA1(3), CCNA2(3), CCNB1(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(1), CDK4(2), CDKN2A(31), E2F3(2), E2F4(3), E2F5(3), EP300(6), ESPL1(4), GSK3B(2), HDAC4(4), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), MDM2(2), MPEG1(2), PRKDC(7), PTPRA(1), PTTG2(1), RB1(3), RBL1(2), SKP2(3), SMAD4(32), TBC1D8(3), TFDP1(1), TGFB1(1), TP53(100)	24567895	286	124	243	24	63	39	42	50	91	1	2.10e-13	8.25e-10	2.03e-08
26	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), CPEB1(1), EGFR(2), ERBB2(6), ERBB4(6), ETS1(2), ETS2(2), ETV6(1), ETV7(1), FMN2(4), KRAS(127), NOTCH1(9), NOTCH2(6), NOTCH3(7), NOTCH4(5), PIWIL1(2), PIWIL2(3), PIWIL3(2), PIWIL4(1), SOS1(2), SOS2(1)	11749208	193	125	69	30	19	67	78	19	10	0	2.31e-06	2.72e-09	6.45e-08
27	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCNB1(1), CCND2(3), CCND3(1), CCNE1(1), CDC25A(1), CDK4(2), CDK6(2), CDK7(1), CDKN2A(31), RB1(3), RBL1(2), TFDP1(1)	3597480	52	38	40	7	2	10	8	6	26	0	0.0317	1.24e-08	2.83e-07
28	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(1), AKT1(1), AKT2(2), AKT3(2), APAF1(3), ATM(10), BAD(1), BIRC2(2), CAPN1(1), CASP10(4), CASP3(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CSF2RB(2), DFFB(1), FASLG(1), IKBKB(4), IL1B(1), IL1R1(2), IL1RAP(2), IL3RA(2), IRAK3(1), IRAK4(1), NFKB2(1), NFKBIA(1), NTRK1(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF1A(2), TP53(100), TRADD(1), TRAF2(2)	18722526	198	114	169	21	54	33	25	34	52	0	1.75e-09	1.64e-06	3.62e-05
29	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(10), CCNA1(3), CCNB1(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(1), CDK4(2), CDK7(1), CDKN2A(31), CREB3L1(1), CREB3L3(1), E2F3(2), E2F4(3), E2F5(3), GBA2(4), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), MDM2(2), MYT1(11), NACA(8), POLA2(1), POLE(8), POLE2(5), PRIM1(1), RB1(3), RBL1(2), RPA1(1), RPA2(2), RPA3(1), TFDP1(1), TNXB(9), TP53(100)	17324559	244	112	202	28	58	34	38	41	72	1	7.66e-10	2.77e-06	5.87e-05
30	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(2), AKT3(2), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), KRAS(127), LCP2(3), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCG1(1), PLCG2(7), PRKCD(4), PRKCE(1), RAC2(1), SOS1(2), SOS2(1), SYK(2), VAV1(4)	16063836	209	126	85	31	21	73	77	22	15	1	3.00e-08	1.83e-05	0.000377
31	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT2(2), AKT3(2), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD72(2), CD81(2), CHUK(1), CR2(5), FCGR2B(2), GSK3B(2), HRAS(1), IKBKB(4), INPP5D(1), KRAS(127), LILRB3(1), MALT1(4), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PTPN6(4), RAC2(1), RASGRP3(2), SYK(2), VAV1(4)	16554143	228	126	106	32	27	83	75	25	17	1	3.59e-10	5.43e-05	0.00105
32	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(2), AKT3(2), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), KRAS(127), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NOS3(8), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCG1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKCG(2), PTK2(10), PXN(1), RAC2(1), SH2D2A(1), SHC2(2), SPHK1(1), SRC(2)	16182739	222	125	97	33	26	78	81	20	17	0	5.87e-09	5.46e-05	0.00105
33	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA3(6), LTB4R(3), P2RY1(6), P2RY2(1), P2RY6(1)	1319717	18	13	16	1	7	5	3	1	2	0	0.00473	0.000122	0.00228
34	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(4), ADCY8(4), ARAF(2), BRAF(3), CACNA1C(8), CALML3(1), CAMK2D(1), CAMK4(1), CREBBP(3), EP300(6), GNAQ(1), GRIA1(1), GRIN1(1), GRIN2A(6), GRIN2B(7), GRIN2C(4), GRIN2D(5), GRM1(9), GRM5(7), HRAS(1), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(127), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKCG(2), RAP1B(3), RAPGEF3(3), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA6(4)	22417489	261	132	138	41	47	77	86	28	21	2	6.05e-10	0.00152	0.0276
35	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BAK1(1), BFAR(2), BTK(1), CAD(6), CASP10(4), CASP3(2), CASP8(2), DAXX(3), DEDD(1), DIABLO(1), EGFR(2), EPHB2(4), FAF1(1), FAIM2(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K5(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MET(4), NFAT5(4), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PTPN13(4), RALBP1(2), ROCK1(5), SMPD1(2), TP53(100), TPX2(2), TRAF2(2)	16463005	181	109	153	25	41	31	28	32	48	1	3.14e-06	0.00522	0.0918
36	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(2), CREBBP(3), EP300(6), NCOA3(16), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RXRA(1)	4570097	38	23	28	5	8	4	5	3	17	1	0.143	0.00572	0.0978
37	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT2(2), AKT3(2), CARD11(3), CBL(3), CBLB(2), CD3E(1), CD4(2), CD8B(2), CDC42(1), CDK4(2), CHUK(1), CTLA4(1), GRAP2(2), HRAS(1), IKBKB(4), ITK(1), KRAS(127), LCK(1), LCP2(3), MALT1(4), NCK1(4), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), RHOA(1), SOS1(2), SOS2(1), TEC(2), VAV1(4), ZAP70(6)	22579789	250	128	126	38	35	88	78	27	20	2	3.35e-09	0.0149	0.247
38	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(5), ABL2(2), AKT1(1), AKT2(2), AKT3(2), ARAF(2), BAD(1), BRAF(3), CAMK2D(1), CBL(3), CBLB(2), CRK(1), CRKL(1), EGF(5), EGFR(2), ELK1(2), ERBB2(6), ERBB3(5), ERBB4(6), GAB1(1), GSK3B(2), HRAS(1), KRAS(127), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK9(1), NCK1(4), NCK2(2), NRG1(4), NRG2(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(10), RPS6KB2(1), SHC1(1), SHC2(2), SHC4(1), SOS1(2), SOS2(1), SRC(2), STAT5A(1)	23007042	259	128	133	35	39	80	86	26	27	1	4.35e-10	0.0200	0.324
39	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), BRAF(3), CACNA1A(8), CRHR1(1), GNA11(2), GNAI1(1), GNAI2(1), GNAO1(3), GNAQ(1), GNAS(12), GNAZ(1), GRIA1(1), GRIA3(2), GRID2(8), GRM1(9), GRM5(7), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), HRAS(1), IGF1R(6), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(127), NOS1(7), NOS3(8), NPR1(1), NPR2(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(23)	24729363	306	132	179	44	74	74	100	34	24	0	1.30e-11	0.0265	0.418
40	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), ADRB2(1), CFTR(7), GNAS(12), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1)	2957408	33	18	25	3	15	6	4	4	4	0	0.0101	0.0274	0.422
41	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), BRAF(3), CASP3(2), FASLG(1), FCGR3B(1), HLA-A(2), HLA-G(2), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(3), IFNGR1(2), ITGAL(2), ITGB2(1), KIR2DL1(3), KIR2DL3(2), KIR3DL1(2), KLRC3(3), KRAS(127), LCK(1), LCP2(3), NCR1(1), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRF1(1), PRKCG(2), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(1), SOS1(2), SOS2(1), SYK(2), TNFRSF10A(2), TNFRSF10B(2), VAV1(4), ZAP70(6)	25297910	250	129	126	44	37	82	79	29	22	1	8.35e-08	0.0351	0.528
42	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), TGFB1(1), TGFBR1(8), TGFBR2(10)	2344836	20	14	20	4	5	3	2	3	7	0	0.272	0.0373	0.547
43	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), AKAP10(2), AKAP11(3), AKAP12(6), AKAP3(2), AKAP4(1), AKAP6(5), AKAP7(2), AKAP9(7), ARHGEF1(2), CHMP1B(1), GNA11(2), GNA14(1), GNA15(3), GNAI2(1), GNAL(2), GNAO1(3), GNAQ(1), GNAZ(1), GNB1(3), GNB2(1), GNB3(2), GNB5(1), HRAS(1), ITPR1(10), KRAS(127), PALM2(1), PDE1B(1), PDE1C(1), PDE4A(1), PDE4C(2), PDE4D(3), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(4), PRKCQ(2), PRKD3(4), RHOA(1), RRAS(2), USP5(2)	26044372	274	131	151	56	56	85	89	31	11	2	3.60e-07	0.0410	0.587
44	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), CALML3(1), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(3), CTNNB1(7), DCT(4), DVL1(4), DVL2(4), DVL3(1), EDN1(1), EDNRB(2), EP300(6), FZD1(5), FZD10(6), FZD2(2), FZD3(3), FZD7(2), FZD8(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(3), GNAQ(1), GNAS(12), GSK3B(2), HRAS(1), KIT(4), KRAS(127), LEF1(2), MITF(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), POMC(1), PRKACB(1), PRKACG(3), PRKCG(2), TCF7(1), TCF7L1(4), TCF7L2(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT3A(4), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2)	24649361	303	131	174	59	82	84	86	32	19	0	5.88e-10	0.0521	0.730
45	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), FHL5(1), FSHB(1), FSHR(3), GNAS(12), XPO1(2)	2159135	23	14	18	2	12	2	4	3	2	0	0.0709	0.0636	0.870
46	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), BAD(1), MUSK(6), PIK3CA(4), PIK3R1(1), PTK2(10), SRC(2), TERT(5), YWHAH(1)	3679200	31	16	27	4	5	7	3	6	10	0	0.0459	0.0974	1.000
47	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(12), GNB1(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2195611	24	13	19	2	14	4	3	2	1	0	0.0212	0.132	1.000
48	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB27A(2), RAB3A(1), RAB4A(2), RAB6A(1), RAB9A(1)	941380	11	5	11	1	5	3	1	1	1	0	0.0815	0.138	1.000
49	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(5), ANAPC1(5), ANAPC2(4), ANAPC4(3), ANAPC5(5), ANAPC7(1), ATM(10), ATR(9), BUB1(3), BUB3(1), CCNA1(3), CCNA2(3), CCNB1(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(2), CDC14B(1), CDC16(1), CDC23(1), CDC25A(1), CDC25B(1), CDC27(7), CDC6(1), CDC7(2), CDK4(2), CDK6(2), CDK7(1), CDKN2A(31), CREBBP(3), CUL1(2), E2F3(2), EP300(6), ESPL1(4), GSK3B(2), MAD1L1(1), MAD2L1(1), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), MDM2(2), PKMYT1(2), PRKDC(7), PTTG2(1), RB1(3), RBL1(2), RBL2(6), SKP1(1), SKP2(3), SMAD2(1), SMAD4(32), SMC1A(2), SMC1B(3), TFDP1(1), TGFB1(1), TP53(100), YWHAE(2), YWHAG(1), YWHAH(1)	30324667	325	127	279	34	66	48	49	51	110	1	3.91e-11	0.173	1.000
50	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(1), GNB1(3), HTR2C(5), PLCB1(1), TUB(2)	1571371	13	9	13	2	4	3	0	4	2	0	0.196	0.178	1.000
51	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2)	2775102	29	12	29	6	7	7	5	4	6	0	0.128	0.186	1.000
52	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), CSNK1D(1), DRD1(5), EGF(5), EGFR(2), GJA1(1), GNA11(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(12), GRM1(9), GRM5(7), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), HRAS(1), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(127), MAP3K2(2), MAPK7(4), NPR1(1), NPR2(2), PDGFC(2), PDGFRA(3), PDGFRB(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PRKACB(1), PRKACG(3), PRKCG(2), PRKG1(1), PRKG2(1), SOS1(2), SOS2(1), SRC(2), TJP1(6), TUBA1A(2), TUBA1B(1), TUBA3C(3), TUBA3D(3), TUBA3E(4), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(1), TUBB3(2), TUBB6(1), TUBB8(2)	29541835	323	133	195	52	79	93	94	35	22	0	2.44e-12	0.189	1.000
53	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(3), CAMP(2), CREB1(2), CREB5(1), SNX13(5), SRC(2), TERF2IP(1)	2499222	19	10	19	2	2	2	4	4	7	0	0.203	0.194	1.000
54	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), BDH1(1), BDH2(1), HMGCS2(2), OXCT1(2), OXCT2(1)	1598389	10	6	10	1	1	4	0	1	4	0	0.200	0.196	1.000
55	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(1), AKT1(1), ANXA1(3), GNAS(12), GNB1(3), NOS3(8), NR3C1(2), PIK3CA(4), PIK3R1(1), RELA(2), SYT1(2)	4041489	39	22	34	6	13	4	11	7	3	1	0.0967	0.205	1.000
56	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), CACNA1C(8), CACNA1D(10), CACNA1F(4), CACNA1S(5), CALML3(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), ELK1(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(12), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(127), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(2), MMP2(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLD2(4), PRKACB(1), PRKACG(3), PRKCD(4), SOS1(2), SOS2(1), SRC(2)	28702594	302	132	173	51	62	86	96	32	23	3	1.29e-10	0.210	1.000
57	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(2), GLI2(4), GLI3(10), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(1), SUFU(1)	3738609	32	15	32	9	14	6	5	6	1	0	0.130	0.267	1.000
58	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNAS(12), GNB1(3), PRKAR1A(1)	1510477	20	12	15	3	11	4	2	2	1	0	0.118	0.275	1.000
59	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(5), MST1R(7)	1441687	15	10	14	4	2	3	1	4	5	0	0.442	0.278	1.000
60	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(4)	710771	5	4	5	1	3	0	0	0	2	0	0.520	0.287	1.000
61	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3E(1), CD80(2), CD86(6), CTLA4(1), ITK(1), LCK(1), PIK3CA(4), PIK3R1(1)	2800525	17	11	15	3	4	1	3	3	5	1	0.311	0.290	1.000
62	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), CAT(1), GHR(2), HRAS(1), IGF1R(6), PIK3CA(4), PIK3R1(1), SHC1(1)	2936435	17	10	17	3	5	2	2	4	3	1	0.211	0.291	1.000
63	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(2), UGP2(3), UXS1(2)	1090157	8	6	8	2	0	2	2	4	0	0	0.605	0.328	1.000
64	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F5(8), FGA(4), FGB(4), FGG(2), PROC(1), PROS1(2), SERPINC1(3), TFPI(2)	3603289	30	12	29	9	3	6	14	5	2	0	0.501	0.328	1.000
65	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), OXCT1(2)	740133	5	3	5	0	0	3	0	0	2	0	0.324	0.333	1.000
66	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), CREB1(2), HRAS(1), MAPK7(4), MEF2A(1), MEF2C(3), MEF2D(2), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RPS6KA1(2), SHC1(1)	4232061	25	15	25	2	6	6	5	3	5	0	0.0201	0.334	1.000
67	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(5), UBE2F(1), UBE2G2(1)	1408791	10	5	10	1	4	1	3	1	1	0	0.127	0.337	1.000
68	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(2)	440347	2	2	2	0	1	1	0	0	0	0	0.477	0.340	1.000
69	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(1), LDLR(1), LPL(3)	1165731	9	4	9	0	3	3	1	1	1	0	0.0288	0.344	1.000
70	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), OPRK1(2), POLR2A(5), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2859762	17	10	17	2	10	1	3	1	2	0	0.0627	0.352	1.000
71	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), BCMO1(2), RDH5(1)	849793	4	3	4	0	2	0	1	1	0	0	0.288	0.368	1.000
72	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADCY1(4), ADRB2(1), GNAS(12), PLCE1(5), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(2)	3366506	32	16	27	4	16	3	5	6	2	0	0.0313	0.372	1.000
73	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(3)	360199	4	2	4	0	2	1	0	1	0	0	0.236	0.377	1.000
74	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(1), DRD1(5), GRM1(9), PLCB1(1), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	3547533	30	13	29	5	12	5	4	6	3	0	0.0471	0.388	1.000
75	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(7), CDH1(1), CREBBP(3), EP300(6), MAP3K7(2), SKIL(1), TGFB1(1), TGFBR1(8), TGFBR2(10)	5652822	39	20	39	7	11	5	7	7	9	0	0.125	0.388	1.000
76	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(4), HK2(6), HK3(4), PGM1(1), PGM3(1), TGDS(1)	2259501	18	10	18	4	8	1	3	0	6	0	0.291	0.405	1.000
77	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNAS(12), GNB1(3), PPP2CA(1), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	3459902	34	16	29	4	15	7	3	4	5	0	0.0145	0.405	1.000
78	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLS(2), OAT(2), PRODH(2)	1250874	10	4	10	1	3	1	2	1	3	0	0.160	0.406	1.000
79	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), PRKACB(1), PRKACG(3), PRKAR2B(1)	2228145	13	8	12	4	2	2	2	2	4	1	0.781	0.414	1.000
80	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(3), EP300(6), IKBKB(4), IL1B(1), MAP2K3(1), MAP2K6(3), MAP3K7(2), MAPK11(1), NFKBIA(1), NR3C1(2), RELA(2), TGFBR1(8), TGFBR2(10), TLR2(3)	6614651	48	22	48	8	11	8	8	6	15	0	0.0454	0.418	1.000
81	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT2(2), ST3GAL4(2)	1595902	8	5	8	1	6	0	0	2	0	0	0.205	0.424	1.000
82	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(3), GPI(3), HK1(4), PFKL(2), PGAM1(2), PGK1(3), PKLR(2), TPI1(3)	2059677	24	11	24	6	10	8	1	2	3	0	0.0958	0.440	1.000
83	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), JAK1(1), JAK2(6), STAT1(3)	1798166	12	8	11	3	2	0	3	2	5	0	0.728	0.457	1.000
84	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(2), MTMR6(2), NFS1(1), PHPT1(1), TPK1(2)	1409859	8	5	8	2	3	2	2	0	1	0	0.607	0.461	1.000
85	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD2(3)	1009220	5	3	5	2	2	1	1	0	1	0	0.673	0.462	1.000
86	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1)	250022	1	1	1	0	0	0	0	0	1	0	0.843	0.464	1.000
87	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADH(1), HADHA(1), HADHB(2), HSD17B4(3), MECR(2), PPT1(1), PPT2(1)	1876036	11	5	11	0	3	3	1	2	2	0	0.0309	0.475	1.000
88	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(3)	1455457	7	4	7	1	4	0	1	1	1	0	0.309	0.493	1.000
89	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(2), PAPSS2(6), SULT1A2(1), SULT2A1(1), SUOX(1)	1332992	13	4	12	2	1	2	1	4	5	0	0.375	0.510	1.000
90	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(2), TPI1(3)	852697	6	3	6	1	3	2	0	1	0	0	0.295	0.512	1.000
91	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(2), UXS1(2)	861396	5	4	5	2	0	1	2	2	0	0	0.837	0.519	1.000
92	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(6), RANGAP1(2)	1848692	9	4	9	0	1	3	2	1	1	1	0.0700	0.520	1.000
93	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), HRAS(1), SHC1(1), SOS1(2), SRC(2)	1950891	8	5	8	2	2	3	0	1	2	0	0.432	0.530	1.000
94	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), AOC3(3), CES1(2), ESD(1)	1324270	8	4	8	1	3	2	3	0	0	0	0.201	0.532	1.000
95	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(2), HADHA(1)	1067768	4	3	4	1	2	0	1	0	1	0	0.515	0.535	1.000
96	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(2), CASP8(2), CFLAR(3)	850719	7	4	7	3	1	0	1	1	4	0	0.841	0.538	1.000
97	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(3), NR1H4(1), RXRA(1)	1195014	6	4	6	1	2	3	1	0	0	0	0.194	0.540	1.000
98	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(1), CAPNS1(2), CAPNS2(2), CDK5R1(1), CSNK1D(1), GSK3B(2), MAPT(3), PPP2CA(1)	2109465	16	8	16	3	7	5	1	2	1	0	0.0950	0.543	1.000
99	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(4), CCNB1(1), GNAI1(1), GNAS(12), GNB1(3), HRAS(1), MYT1(11), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), SRC(2)	4619824	48	21	43	7	22	11	5	7	3	0	0.00410	0.547	1.000
100	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	408159	2	2	2	0	1	0	0	1	0	0	0.564	0.552	1.000
101	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(9), BMPR1A(3), BMPR2(3)	1377092	15	6	15	3	4	6	3	1	1	0	0.220	0.561	1.000
102	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC2(1), CDC42(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), WASL(2)	2932865	13	7	13	3	2	4	2	4	1	0	0.374	0.565	1.000
103	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), KERA(2), LUM(2)	794878	5	2	5	1	1	0	1	3	0	0	0.543	0.569	1.000
104	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(3), EPHB1(2), ITGA1(7), L1CAM(5), RAP1B(3), SELP(2)	3454840	25	14	23	4	11	5	2	3	4	0	0.0571	0.589	1.000
105	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(1), ACAT1(2), HADHA(1)	1197175	7	3	7	0	1	4	1	1	0	0	0.0988	0.593	1.000
106	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(1), ACSL1(1), ACSL3(4), ACSL4(3), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), SCP2(1)	3710199	18	8	18	1	6	4	4	2	2	0	0.0157	0.595	1.000
107	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(3), IDH2(5), OGDH(5), SDHA(3), SUCLA2(1)	2063701	17	8	17	4	3	3	5	4	2	0	0.315	0.599	1.000
108	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	158041	2	1	2	0	2	0	0	0	0	0	0.511	0.606	1.000
109	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDC34(1), CUL1(2), FBXW7(5), RB1(3), TFDP1(1)	1851788	13	6	13	6	2	2	2	3	4	0	0.882	0.614	1.000
110	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(3), UBE2D1(1), UBE2E1(1), UBE2E3(2), UBE2G2(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(4)	2329050	17	6	16	1	8	4	4	1	0	0	0.0122	0.639	1.000
111	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(3), LPO(5), MPO(2), TPO(7)	1861565	21	10	21	5	11	1	4	2	3	0	0.179	0.643	1.000
112	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), EPO(2), IL6(1), IL7(1), IL9(1)	1360857	9	3	9	1	1	1	2	4	1	0	0.291	0.650	1.000
113	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(4), AKT1(1), BAD(1), CSF2RB(2), IGF1R(6), IL3RA(2), KIT(4), PIK3CA(4), PIK3R1(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1)	4850819	34	13	34	7	12	6	4	8	4	0	0.0519	0.654	1.000
114	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(1), CDC25B(1), CSK(1), PTPRA(1), SRC(2)	2029853	7	7	7	2	2	2	2	0	1	0	0.561	0.657	1.000
115	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(4), AKT1(1), CAMK2D(1), CREB1(2), GNAS(12), HRAS(1), PIK3CA(4), PIK3R1(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(2), RPS6KA5(2), SOS1(2)	6512921	40	21	35	6	17	6	5	7	5	0	0.0328	0.661	1.000
116	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), CAMKK1(1), CREB1(2), SYT1(2)	2582620	11	6	11	1	2	1	2	0	5	1	0.231	0.664	1.000
117	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(1), FOSL2(3), IFNAR1(2), IFNAR2(3), MAPK8(2), RELA(2), TNFRSF11A(2), TRAF6(1)	2463556	16	7	16	4	1	3	5	5	2	0	0.472	0.664	1.000
118	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(2), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), EHHADH(2), GAD1(5), GAD2(7), HADHA(1), L2HGDH(2), OXCT1(2), PDHA1(2), PDHA2(2)	5694611	37	16	37	6	10	8	8	3	7	1	0.0390	0.668	1.000
119	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(3), GALNT10(5), GALNT2(3), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), WBSCR17(2)	3157017	24	11	23	6	11	3	7	2	1	0	0.233	0.668	1.000
120	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(2)	1239594	13	4	13	2	5	2	3	0	3	0	0.0913	0.673	1.000
121	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4)	1231575	14	3	14	4	5	3	2	2	2	0	0.424	0.675	1.000
122	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGP2(3), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), XYLB(1)	5955820	30	14	29	3	4	9	4	9	4	0	0.0206	0.703	1.000
123	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	JUND(1), PPP1R1B(1)	853705	2	2	2	0	0	0	0	1	1	0	0.809	0.703	1.000
124	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(4), CRY1(1), CRY2(1), CSNK1E(1), PER1(3)	1917567	11	4	11	2	3	1	0	3	4	0	0.347	0.703	1.000
125	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(3), JAK1(1), JAK2(6), TYK2(2)	2307327	13	8	12	3	2	0	3	1	7	0	0.777	0.710	1.000
126	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(3), JAK1(1), JAK2(6), TYK2(2)	2307327	13	8	12	3	2	0	3	1	7	0	0.777	0.710	1.000
127	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(5), CASP1(1), CASP10(4), CASP3(2), CASP8(2), CASP9(1), PRF1(1)	2835077	19	8	19	4	3	4	1	3	8	0	0.338	0.713	1.000
128	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(4), GLS(2), GOT1(2)	1715149	11	3	11	0	3	2	1	3	1	1	0.0342	0.714	1.000
129	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(2), ELK1(2), GNAS(12), GNB1(3), HRAS(1), IGF1R(6), KLK2(1), MKNK2(1), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA1(2), RPS6KA5(2), SHC1(1), SOS1(2), SRC(2), STAT3(2)	7429605	44	25	39	9	17	11	4	5	7	0	0.0513	0.720	1.000
130	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), HRAS(1), IGF1R(6), IRS1(4), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1)	5482417	27	16	27	6	7	4	1	7	8	0	0.241	0.720	1.000
131	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(1), BDKRB2(1), KNG1(1), NOS3(8), REN(3)	2224391	16	6	16	2	7	2	6	1	0	0	0.0615	0.723	1.000
132	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDK7(1)	1571987	3	3	3	1	1	0	1	0	1	0	0.737	0.723	1.000
133	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), FUT9(1), HEXA(2), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2)	2240350	15	6	15	1	8	2	3	0	2	0	0.0315	0.724	1.000
134	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(2)	491313	2	1	2	2	0	0	0	1	1	0	0.934	0.726	1.000
135	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), CREB1(2), EDN1(1), EP300(6), EPO(2), HIF1A(1), NOS3(8)	3772883	23	9	23	2	8	2	6	2	5	0	0.0371	0.727	1.000
136	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(2), HDAC9(6), MEF2A(1), MEF2C(3), MEF2D(2), YWHAH(1)	1769598	17	9	17	3	3	3	7	1	3	0	0.239	0.736	1.000
137	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR161(1), GPR171(2), GPR18(1), GPR34(1), GPR39(4), GPR65(2), GPR75(1)	2172757	13	8	13	3	2	5	1	4	1	0	0.208	0.737	1.000
138	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), FH(3), IDH1(1), IDH2(5), SUCLA2(1)	1950002	12	6	12	2	1	3	5	2	1	0	0.334	0.740	1.000
139	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(2)	872277	4	2	4	1	0	0	1	1	1	1	0.845	0.744	1.000
140	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(12), GNB1(3), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(6)	5181404	43	19	38	6	20	8	6	5	4	0	0.00610	0.745	1.000
141	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(12), GNB1(3), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(6)	5181404	43	19	38	6	20	8	6	5	4	0	0.00610	0.745	1.000
142	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2)	522538	2	1	2	1	0	0	0	1	1	0	0.905	0.750	1.000
143	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), BAD(1), HRAS(1), IGF1R(6), IRS1(4), PIK3CA(4), PIK3R1(1), SHC1(1), SOS1(2), YWHAH(1)	4161313	22	13	22	6	7	4	1	6	4	0	0.346	0.753	1.000
144	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(2), ILK(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTK2(10), SHC1(1), SOS1(2)	4315007	25	12	22	3	4	4	5	4	8	0	0.132	0.760	1.000
145	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(6), IFNGR1(2), IL12B(1), IL4R(3)	2787125	12	9	10	4	3	1	2	2	4	0	0.583	0.764	1.000
146	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), KEAP1(2), MAFF(2), MAPK8(2)	1996057	8	4	8	1	2	0	1	2	3	0	0.367	0.766	1.000
147	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ARPC1A(1), ARPC2(1), NCK1(4), NCKAP1(5), NTRK1(2), PIR(2), WASF1(1), WASF2(1), WASF3(1), WASL(2)	3375482	23	8	23	4	8	6	2	4	3	0	0.128	0.767	1.000
148	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(2)	718525	6	4	5	3	2	2	1	0	1	0	0.727	0.769	1.000
149	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(10), CDC25A(1), CDC25B(1), MYT1(11), YWHAH(1)	3027886	24	10	24	5	7	4	4	5	4	0	0.255	0.769	1.000
150	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4), SPCS1(1)	680580	7	3	7	2	1	1	2	3	0	0	0.638	0.771	1.000
151	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), APOA4(3), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(5), LDLR(1), LPL(3), LRP1(15), SCARB1(1), SOAT1(1)	6038956	41	20	41	8	17	10	4	3	6	1	0.0150	0.774	1.000
152	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC3B(2), APOBEC3G(1)	1607383	6	3	6	1	3	2	0	1	0	0	0.313	0.782	1.000
153	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(4), DPYS(3), ENPP3(3), PANK2(1), PANK3(1), PANK4(1), UPB1(2)	3114674	18	9	18	4	5	7	3	2	1	0	0.140	0.786	1.000
154	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(2), ADSL(2), ADSS(1), AGXT(2), AGXT2(1), ASL(2), ASNS(3), ASPA(1), CAD(6), DARS(1), DDO(2), GAD1(5), GAD2(7), GOT1(2), GPT(1), GPT2(2), PC(3)	5767932	45	17	45	11	12	9	12	6	5	1	0.132	0.796	1.000
155	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ARPC1A(1), ARPC2(1), CDC42(1), WASF1(1), WASL(2)	1782887	9	4	9	4	2	4	1	2	0	0	0.652	0.804	1.000
156	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), CREB1(2), ELK1(2), GNAI1(1), GNAQ(1), GNAS(12), GNB1(3), HRAS(1), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA3(1), SYT1(2)	7836018	55	23	50	9	21	13	4	7	9	1	0.00843	0.810	1.000
157	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(2)	3445214	14	8	14	3	4	3	2	4	1	0	0.316	0.812	1.000
158	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(3), RDH11(2)	1069849	6	2	6	0	1	0	2	2	1	0	0.192	0.816	1.000
159	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD3B1(2)	1791234	11	3	11	4	1	5	2	2	1	0	0.505	0.817	1.000
160	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(4), ICAM1(2), ITGAL(2), ITGAM(4), ITGB2(1), SELE(2), SELL(1)	2321608	16	7	15	4	4	2	1	3	6	0	0.325	0.821	1.000
161	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(3), CASP1(1), CASP3(2), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(2), MAGI2(10), RERE(6), WWP1(2), WWP2(5)	5321058	42	18	41	9	14	8	5	5	10	0	0.0852	0.823	1.000
162	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(4), HK2(6), HK3(4), ISYNA1(1), PGM1(1), PGM3(1), TGDS(1)	2593940	19	10	19	5	9	1	3	0	6	0	0.317	0.824	1.000
163	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(7), AXIN1(3), BMP10(1), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMPR1A(3), BMPR2(3), CHRD(2), CTNNB1(7), DVL1(4), FZD1(5), GATA4(1), GSK3B(2), MAP3K7(2), MEF2C(3), NKX2-5(1), RFC1(3), TGFB1(1), TGFBR1(8), TGFBR2(10), WNT1(1)	8138527	73	27	73	8	24	15	10	16	8	0	0.000204	0.825	1.000
164	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), EHHADH(2), GCDH(2), HADHA(1)	1718262	8	3	8	1	2	2	2	0	2	0	0.257	0.826	1.000
165	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(3), GGT1(1), SHMT1(1), SHMT2(2)	1252078	8	5	8	6	3	1	1	1	1	1	0.895	0.827	1.000
166	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3E(1), CD4(2)	705764	3	1	3	1	0	0	0	1	2	0	0.839	0.831	1.000
167	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), HRAS(1), INSR(4), IRS1(4), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1)	5647326	25	14	25	5	7	4	1	7	6	0	0.182	0.833	1.000
168	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(4), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2)	2118689	11	7	11	4	5	2	2	2	0	0	0.484	0.835	1.000
169	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B1(4), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2)	2118689	11	7	11	4	5	2	2	2	0	0	0.484	0.835	1.000
170	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(4), DLL1(2), FURIN(2), NOTCH1(9), PSEN1(1)	2155455	18	7	18	7	7	7	1	1	2	0	0.296	0.837	1.000
171	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(2), TAT(1), TYR(4)	1028874	8	3	8	3	2	1	3	2	0	0	0.742	0.838	1.000
172	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), PC(3), PCK1(3), SDHA(3), SUCLA2(1), SUCLG1(3)	4541351	28	11	28	5	5	6	11	5	1	0	0.111	0.840	1.000
173	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAT1(2), ACAT2(1), EHHADH(2), HADHA(1), HADHB(2)	1837249	9	3	9	1	1	3	1	0	4	0	0.214	0.841	1.000
174	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEPR(7), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2)	3177090	18	7	18	3	2	6	1	2	7	0	0.186	0.843	1.000
175	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), SQLE(2)	954083	6	4	5	3	2	2	1	0	1	0	0.730	0.852	1.000
176	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(4), AKT1(1), ASAH1(1), GNAI1(1), GNB1(3), ITGAV(3), ITGB3(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCB1(1), PTK2(10), SMPD1(2), SPHK1(1), SRC(2)	6050059	38	15	35	5	7	10	4	6	11	0	0.0370	0.855	1.000
177	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(4), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4)	2820243	12	5	12	4	2	3	1	4	1	1	0.612	0.856	1.000
178	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GCK(1), GFPT1(2), GNE(1), GNPDA1(2), HEXA(2), HEXB(2), HK1(4), HK2(6), HK3(4), PGM3(1), RENBP(1), UAP1(1)	3751281	29	14	29	7	12	4	5	0	8	0	0.281	0.858	1.000
179	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD1(5), GAD2(7), GGT1(1)	1283495	15	7	15	7	4	3	4	1	2	1	0.763	0.861	1.000
180	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	3939983	23	7	23	6	4	2	5	4	6	2	0.337	0.861	1.000
181	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO3(1), FARS2(1), GOT1(2), PAH(1), TAT(1)	1812558	9	5	9	2	3	2	2	2	0	0	0.426	0.863	1.000
182	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(1), AKT2(2), AKT3(2), BAD(1), BTK(1), CDKN2A(31), DAPP1(2), GSK3A(1), GSK3B(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(4), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(2), SOS2(1), TEC(2), YWHAE(2), YWHAG(1), YWHAH(1)	8036930	70	43	58	12	9	13	6	11	31	0	0.0367	0.867	1.000
183	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(3), NR3C1(2), PPARG(1), RXRA(1)	1273638	8	3	8	2	3	1	2	1	1	0	0.384	0.868	1.000
184	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASS(2), KARS(1)	1035708	5	2	5	3	0	0	1	1	3	0	0.979	0.870	1.000
185	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CDC25A(1), CDC25B(1), CDK7(1), XPO1(2)	1926510	6	5	6	2	2	0	1	0	3	0	0.741	0.872	1.000
186	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(1), PSMB1(1), PSMB4(4), PSMB5(2), PSMB7(1), UBE3A(4)	2849997	17	10	17	5	7	1	3	3	3	0	0.458	0.872	1.000
187	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(2), HADH(1), HADHA(1), HSD17B4(3), SIRT1(1)	2615365	9	4	9	0	4	1	1	2	1	0	0.0506	0.879	1.000
188	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(4), CR2(5), FCGR2B(2), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(2)	3342277	20	11	20	7	5	5	1	5	3	1	0.489	0.884	1.000
189	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(2), CHST12(1), PAPSS1(2), PAPSS2(6), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(1)	2070556	17	8	16	3	4	2	2	4	5	0	0.289	0.886	1.000
190	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(4), PCYT1A(2), PDHA1(2), PDHA2(2), SLC18A3(3)	1572002	16	10	16	8	5	3	5	1	2	0	0.703	0.886	1.000
191	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(5), CTNNB1(7), PTK2(10), PXN(1), SRC(2), VCL(1)	4330927	38	12	35	4	13	9	2	7	7	0	0.00478	0.886	1.000
192	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), AFMID(2), GRHPR(1), HAO1(1), HAO2(2), MTHFD1(2), MTHFD1L(1), MTHFD2(1)	2938045	12	5	12	1	3	3	1	1	3	1	0.105	0.889	1.000
193	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), FBP2(1), GOT1(2), GPT(1), GPT2(2), ME1(2), ME2(6), ME3(1), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3)	3994140	29	9	29	3	4	10	8	3	4	0	0.00709	0.891	1.000
194	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(1), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2)	1521540	8	4	8	2	1	2	3	2	0	0	0.378	0.892	1.000
195	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT5(1), FUT6(2)	1137293	5	2	5	0	3	2	0	0	0	0	0.0885	0.892	1.000
196	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	146	APC(7), APC2(2), AXIN1(3), AXIN2(1), BTRC(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(7), CREBBP(3), CSNK1A1L(4), CSNK1E(1), CSNK2A1(1), CTBP2(4), CTNNB1(7), CUL1(2), CXXC4(1), DAAM1(9), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(4), DVL3(1), EP300(6), FBXW11(1), FOSL1(1), FZD1(5), FZD10(6), FZD2(2), FZD3(3), FZD7(2), FZD8(1), FZD9(2), GSK3B(2), LEF1(2), LRP5(7), LRP6(5), MAP3K7(2), MAPK8(2), MAPK9(1), MMP7(1), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NKD1(4), NLK(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPARD(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRICKLE1(2), PRICKLE2(2), PRKACB(1), PRKACG(3), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(5), ROCK2(2), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD2(1), SMAD4(32), SOX17(1), TCF7(1), TCF7L1(4), TCF7L2(1), TP53(100), VANGL1(1), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT3A(4), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2)	36519302	372	131	338	67	114	62	48	68	79	1	1.42e-09	0.892	1.000
197	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(2), AKT3(2), ELK1(2), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(4), PIK3CD(2), SHC1(1), SOS1(2)	3660069	20	10	20	6	7	2	3	5	3	0	0.472	0.894	1.000
198	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(2), DHFR(1), FTCD(3), GART(1), MTHFD1(2), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(4), SHMT1(1), SHMT2(2), TYMS(1)	4186790	26	8	26	7	5	3	5	5	6	2	0.310	0.895	1.000
199	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(2), PC(3), PDHA1(2), SLC25A1(1)	2048173	11	5	11	4	4	5	1	1	0	0	0.400	0.895	1.000
200	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), ALAS2(3), CPOX(1), HMBS(1), PPOX(1)	1681728	7	5	7	2	3	2	0	1	1	0	0.603	0.896	1.000
201	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(2), CAPNS2(2), ITGA1(7), ITGB3(1), PTK2(10), PXN(1), SPTAN1(4), SRC(2), TLN1(12)	6368183	50	16	47	6	15	12	5	4	13	1	0.00322	0.898	1.000
202	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), JUNB(1), MAF(2), MAP2K3(1), NFATC1(4), NFATC2(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1)	2761198	22	8	22	5	10	6	2	1	3	0	0.0414	0.898	1.000
203	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ACADM(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(3), DPYD(4), DPYS(3), EHHADH(2), GAD1(5), GAD2(7), HADHA(1), UPB1(2)	5965763	37	16	37	5	11	6	9	5	5	1	0.0118	0.902	1.000
204	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(3), DPYD(4), DPYS(3), EHHADH(2), GAD1(5), GAD2(7), HADHA(1), UPB1(2)	6403257	43	18	43	5	13	8	9	6	6	1	0.00280	0.903	1.000
205	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(3), EP300(6), ESR1(1), SRC(2)	3334728	12	7	12	2	3	3	3	1	2	0	0.205	0.904	1.000
206	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RA(2), IL10RB(1), IL6(1), JAK1(1), STAT1(3), STAT3(2), STAT5A(1)	2683714	13	5	13	4	7	2	2	1	1	0	0.444	0.905	1.000
207	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1)	3850910	17	8	17	2	3	4	3	4	3	0	0.122	0.906	1.000
208	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS2(2), DHRS3(2), HSD3B7(3), PON1(1), PON2(1), RDH11(2)	1987487	12	4	12	2	3	1	3	4	1	0	0.279	0.906	1.000
209	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(1), EPX(4), LPO(5), MPO(2), MTHFR(1), SHMT1(1), SHMT2(2), TPO(7)	2569606	25	8	25	7	11	4	5	2	2	1	0.201	0.909	1.000
210	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), MIOX(1), UGDH(2)	1894622	8	5	8	3	3	1	2	2	0	0	0.613	0.910	1.000
211	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), FDPS(1), HMGCR(5), IDI1(1), LSS(1), MVD(2), MVK(1), NQO2(2), SQLE(2), VKORC1(3)	2494159	21	7	20	5	5	7	6	1	2	0	0.151	0.911	1.000
212	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), THBS1(3)	1622076	5	4	5	2	1	2	0	0	2	0	0.744	0.913	1.000
213	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(10), CCND2(3), CDK4(2), EGR1(4), ESR2(2), FSHR(3), GJA4(2), LHCGR(2), MLH1(1), NCOR1(11), NRIP1(2), PGR(4), PRLR(3), SMPD1(2), ZP2(1)	7764446	52	22	52	8	13	7	13	9	10	0	0.0296	0.913	1.000
214	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(2), ESR1(1), GREB1(7), PDZK1(1), TUBA8(4)	2478622	15	7	15	3	3	9	1	1	1	0	0.0473	0.915	1.000
215	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(5), EGFR(2), HRAS(1), PTPRB(12), RASA1(2), SHC1(1), SOS1(2), SRC(2)	5509288	30	12	30	3	2	10	6	6	5	1	0.0219	0.915	1.000
216	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(2), AKT3(2), BPNT1(2), ILK(1), PDK1(1), PIK3CA(4), PIK3CD(2), RBL2(6), SHC1(1), SOS1(2)	4513333	24	11	23	6	4	2	5	7	6	0	0.528	0.915	1.000
217	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(1), DFFB(1), HMGB2(1), TOP2A(3), TOP2B(5)	2113635	13	6	13	2	2	2	2	2	5	0	0.548	0.915	1.000
218	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD4(2), LCK(1), PTPRC(2), ZAP70(6)	2013783	12	3	12	2	3	3	1	2	3	0	0.198	0.915	1.000
219	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(4), HRAS(1), KLK2(1), NGFR(1)	1849224	8	4	8	4	3	0	3	2	0	0	0.813	0.916	1.000
220	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPX1(1), PRKCE(1)	1755007	15	4	14	4	6	4	1	1	2	1	0.228	0.917	1.000
221	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(4), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(1), NPAS2(4), PER1(3), PER2(5), PER3(2)	3812027	23	9	22	4	4	6	3	5	5	0	0.0916	0.918	1.000
222	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), CAT(1), EPX(4), LPO(5), MPO(2), PRDX1(1), SHMT1(1), SHMT2(2), TPO(7)	2626271	25	8	25	7	11	4	6	1	2	1	0.194	0.918	1.000
223	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(2), COASY(2), DPYD(4), DPYS(3), ENPP3(3), ILVBL(2), PANK2(1), PANK3(1), PANK4(1), PPCDC(1), UPB1(2), VNN1(1)	3860645	24	11	24	4	9	8	4	2	1	0	0.0329	0.918	1.000
224	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2)	3313978	23	8	23	5	5	6	8	2	2	0	0.201	0.923	1.000
225	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1), SHMT1(1), SHMT2(2)	950169	4	2	4	6	2	0	1	0	0	1	0.987	0.923	1.000
226	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPHN(1), SRC(2), UBQLN1(3)	2670679	21	6	20	5	7	4	5	2	2	1	0.213	0.926	1.000
227	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPT(1), ENPP3(3), FLAD1(1), RFK(1), TYR(4)	2139722	11	4	11	2	5	3	2	1	0	0	0.261	0.928	1.000
228	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(3), SP1(1), SP3(1)	1468417	6	2	6	0	1	0	3	1	1	0	0.354	0.928	1.000
229	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(2), PDE1B(1), PLCB1(1), PLCB2(4), PRL(6), TRH(2)	2486436	17	8	17	3	7	1	4	2	3	0	0.220	0.928	1.000
230	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(2), HRAS(1), INSR(4), IRS1(4), JAK2(6), PIK3CA(4), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(2), SHC1(1), SOS1(2), SRF(1), STAT5A(1)	7317568	34	18	33	7	10	4	5	6	8	1	0.251	0.931	1.000
231	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(1)	7721079	36	15	36	8	8	6	5	9	8	0	0.281	0.932	1.000
232	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(5), EGFR(2), HGS(2)	2826174	12	4	12	1	0	5	3	2	2	0	0.138	0.932	1.000
233	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(5), ANAPC2(4), ANAPC4(3), ANAPC5(5), ANAPC7(1), BTRC(2), CDC16(1), CDC23(1), CDC27(7), CUL1(2), CUL2(1), CUL3(1), FBXW11(1), FBXW7(5), ITCH(2), SKP1(1), SKP2(3), SMURF2(1), TCEB1(2), TCEB2(1), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(2), WWP1(2), WWP2(5)	8955881	61	29	58	12	15	9	11	11	15	0	0.135	0.935	1.000
234	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(2)	4246708	17	8	17	3	3	4	2	4	4	0	0.222	0.935	1.000
235	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), HRAS(1), JAK2(6), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(3), STAT3(2), STAT5A(1), THPO(1)	6609417	26	13	25	5	4	5	3	5	9	0	0.353	0.935	1.000
236	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(2), MMP2(2), MMP9(3), RECK(3)	1670505	11	4	11	4	5	2	2	0	2	0	0.439	0.935	1.000
237	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(3), ABAT(2), ADSL(2), ADSS(1), ADSSL1(1), AGXT(2), AGXT2(1), ASL(2), ASNS(3), ASPA(1), ASRGL1(1), ASS1(1), CAD(6), DARS(1), DDO(2), DLAT(4), GAD1(5), GAD2(7), GOT1(2), GPT(1), GPT2(2), NARS2(1), PC(3), PDHA1(2), PDHA2(2)	8392616	60	21	60	16	15	14	15	7	8	1	0.130	0.935	1.000
238	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(6), JAK3(3), STAT3(2), TYK2(2)	2638156	14	7	13	7	3	2	3	0	6	0	0.928	0.936	1.000
239	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CAPNS1(2), CAPNS2(2), EP300(6), MEF2D(2), NFATC1(4), NFATC2(3), PPP3CA(2), PPP3CC(1), SYT1(2)	5370880	27	11	27	8	8	8	0	4	6	1	0.223	0.937	1.000
240	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F11(1), F12(2), F13B(2), F5(8), F8(3), FGA(4), FGB(4), FGG(2), LPA(8), PLAT(2), PLAU(1), PLG(1), SERPINE1(2), SERPINF2(1), VWF(5)	7773395	50	21	48	13	13	9	16	6	6	0	0.188	0.938	1.000
241	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), NDUFV2(3)	1543166	10	5	9	4	3	4	0	2	1	0	0.707	0.939	1.000
242	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(2), ACSS2(1), FH(3), IDH1(1), IDH2(5), SUCLA2(1)	2911116	16	7	16	5	5	3	5	2	1	0	0.470	0.940	1.000
243	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A2(2), EIF4G1(8), EIF4G2(1), EIF4G3(5), GHR(2), IRS1(4), PABPC1(9), PDK2(3), PIK3CA(4), PIK3R1(1)	6202937	40	24	35	10	7	6	8	7	11	1	0.579	0.940	1.000
244	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD2(3), CD33(3), CD5(1), IL12B(1), ITGAX(3), TLR2(3), TLR4(1), TLR9(8)	4101440	26	10	26	8	10	4	2	5	5	0	0.466	0.940	1.000
245	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(1), PSMB1(1), PSMB4(4), PSMB5(2), PSMB7(1)	1920504	13	9	13	6	5	0	3	2	3	0	0.783	0.941	1.000
246	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(6), COL4A3(2), COL4A4(4), COL4A5(3), COL4A6(4), F10(4), F11(1), F12(2), F5(8), F8(3), FGA(4), FGB(4), FGG(2), KLKB1(1), PROC(1), PROS1(2), SERPINC1(3), SERPING1(1)	9850314	59	23	58	12	10	11	26	6	5	1	0.128	0.945	1.000
247	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), GRHPR(1), HAO1(1), HAO2(2), MTHFD1(2), MTHFD1L(1), MTHFD2(1)	2803885	10	4	10	0	2	3	1	1	2	1	0.0516	0.945	1.000
248	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	471124	3	1	3	1	0	1	2	0	0	0	0.757	0.945	1.000
249	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), FUT2(2), FUT9(1), HEXA(2), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2)	2375284	13	6	13	2	6	2	3	0	2	0	0.137	0.946	1.000
250	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3E(1), CD4(2), CD58(1), IL6(1)	1375965	9	2	9	1	1	1	1	2	4	0	0.312	0.947	1.000
251	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(2), AASS(2), KARS(1)	1524275	7	2	7	3	0	0	3	1	3	0	0.948	0.947	1.000
252	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(2), ERBB3(5), NRG1(4), UBE2D1(1)	2262250	17	6	17	3	3	3	6	3	2	0	0.265	0.948	1.000
253	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(2), IL1B(1), IL6(1)	1168938	4	1	4	2	0	0	1	1	2	0	0.839	0.949	1.000
254	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2)	3121301	21	8	21	5	4	8	7	1	1	0	0.213	0.949	1.000
255	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(5), EGFR(2), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(1)	8279866	40	18	40	9	6	8	6	10	10	0	0.299	0.950	1.000
256	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS2(1), PDHA1(2), PDHA2(2)	2197324	10	4	10	3	4	2	2	2	0	0	0.543	0.950	1.000
257	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(4), ICAM1(2), ITGA4(1), ITGAL(2), ITGB2(1), SELE(2), SELL(1)	2672720	13	6	13	6	4	1	2	3	3	0	0.649	0.951	1.000
258	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BIK(1), BIRC2(2), CASP3(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), DIABLO(1)	3008592	15	5	15	3	2	3	3	1	5	1	0.438	0.954	1.000
259	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPO(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(6), NFKBIA(1), RELA(2)	2834031	15	6	14	3	4	1	4	0	6	0	0.478	0.955	1.000
260	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT2(2), AKT3(2), BRD4(5), CBL(3), CDC42(1), CDKN2A(31), F2RL2(2), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(2), INPPL1(2), IRS1(4), IRS2(4), IRS4(16), LNPEP(2), PARD3(4), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), SHC1(1), SORBS1(2), SOS1(2), SOS2(1), YWHAE(2), YWHAG(1), YWHAH(1)	13280684	108	66	85	29	16	19	10	16	47	0	0.345	0.955	1.000
261	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), MUT(2)	1094970	3	1	3	2	0	0	0	1	2	0	0.905	0.956	1.000
262	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), BAD(1), CASP9(1), CHUK(1), GHR(2), NFKBIA(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(2), YWHAH(1)	3139179	16	8	16	5	1	3	4	4	3	1	0.656	0.957	1.000
263	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN1(1), GRIN2A(6), GRIN2B(7), GRIN2C(4), GRIN2D(5), NOS1(7), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SYT1(2)	5718322	46	18	45	12	19	7	7	9	3	1	0.0628	0.957	1.000
264	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), FGA(4), FGB(4), FGG(2), PLAT(2), PLAU(1), PLG(1), SERPINE1(2)	2944902	19	6	19	7	3	4	5	5	2	0	0.599	0.957	1.000
265	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), EGFR(2), ELK1(2), GNAQ(1), HRAS(1), MAP2K4(5), MAP3K1(3), MAPK8(2), MEF2A(1), MEF2C(3), MEF2D(2), PTK2(10), SHC1(1), SOS1(2), SRC(2), SYT1(2)	7448311	40	16	37	8	5	7	7	6	14	1	0.250	0.958	1.000
266	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), LPO(5), MPO(2), PRDX1(1), TPO(7), TYR(4)	2144345	23	9	23	8	12	1	6	2	2	0	0.448	0.958	1.000
267	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	2934049	21	5	21	7	8	5	4	2	2	0	0.412	0.959	1.000
268	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	576152	3	1	3	1	0	1	1	1	0	0	0.760	0.964	1.000
269	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(4), ICAM1(2), ITGA4(1), ITGAL(2), ITGAM(4), ITGB2(1), SELE(2), SELL(1), SELP(2)	3537271	19	8	18	6	5	3	2	3	6	0	0.436	0.966	1.000
270	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(5), ARHGEF1(2), GNAQ(1), GNB1(3), MYLK(13), PLCB1(1), ROCK1(5)	4566025	30	14	29	9	6	8	4	5	7	0	0.410	0.966	1.000
271	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(2)	1909796	8	4	8	5	3	1	2	0	2	0	0.843	0.966	1.000
272	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), CREB1(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), PIK3CA(4), PIK3R1(1), RB1(3), RELA(2), SP1(1)	4309068	21	10	21	9	3	1	7	5	5	0	0.908	0.967	1.000
273	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(1), ACTN1(1), ACTN2(4), AKT1(1), AKT2(2), AKT3(2), AMOTL1(1), ASH1L(9), CDC42(1), CDK4(2), CGN(1), CLDN17(3), CLDN22(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(5), CTNNA3(5), CTNNB1(7), CTTN(2), EPB41(4), EPB41L1(3), EPB41L2(2), EPB41L3(4), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(1), INADL(2), JAM2(2), KRAS(127), LLGL1(5), LLGL2(3), MAGI1(2), MAGI2(10), MAGI3(3), MLLT4(4), MPDZ(3), MYH1(6), MYH10(4), MYH11(7), MYH13(3), MYH14(4), MYH15(8), MYH2(3), MYH3(2), MYH4(9), MYH6(6), MYH7(8), MYH7B(10), MYH8(4), MYH9(4), MYL9(1), MYLPF(1), PARD3(4), PARD6A(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), PPP2R3A(4), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(4), PRKCQ(2), RAB13(1), RAB3B(1), RHOA(1), RRAS(2), SPTAN1(4), SRC(2), SYMPK(5), TJP1(6), TJP2(4), TJP3(3), YES1(1)	43339819	387	136	264	76	82	100	112	51	42	0	2.68e-08	0.967	1.000
274	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(2), ACVR1C(1), ACVR2A(4), ACVRL1(1), AMH(1), AMHR2(3), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BMPR1A(3), BMPR2(3), CHRD(2), COMP(2), CREBBP(3), CUL1(2), DCN(1), E2F4(3), E2F5(3), EP300(6), GDF5(1), GDF6(1), GDF7(2), INHBA(2), INHBB(2), INHBC(1), LEFTY2(1), LTBP1(3), PPP2CA(1), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(2), PPP2R2C(1), RBL1(2), RBL2(6), RHOA(1), ROCK1(5), ROCK2(2), RPS6KB2(1), SKP1(1), SMAD2(1), SMAD4(32), SMAD7(1), SMAD9(3), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), TGFBR1(8), TGFBR2(10), THBS1(3), THBS2(4), THBS3(1), THBS4(2), ZFYVE16(6), ZFYVE9(5)	22160127	172	76	168	33	41	33	27	26	45	0	0.00126	0.969	1.000
275	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(2), PGAP1(2), PIGB(2), PIGC(1), PIGG(2), PIGL(2), PIGM(1), PIGO(4), PIGQ(6), PIGS(3), PIGW(2)	5345783	27	11	27	3	6	6	6	4	5	0	0.0185	0.969	1.000
276	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(3), GSK3B(2), PPP1CA(1)	2555346	12	4	12	4	2	3	4	0	3	0	0.702	0.970	1.000
277	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(4), FH(3), IDH2(5), IDH3A(2), IDH3G(2), OGDH(5), PC(3), PDHA1(2), PDHA2(2), PDK1(1), PDK2(3), PDK4(1), SDHA(3), SUCLA2(1), SUCLG1(3)	6292420	40	15	40	8	9	8	13	6	4	0	0.0778	0.971	1.000
278	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), RELN(13), VLDLR(3)	3077704	17	10	17	8	6	3	3	2	2	1	0.813	0.972	1.000
279	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(1), GOT1(2), PAH(1), TAT(1)	1916203	7	4	7	3	2	2	2	1	0	0	0.734	0.972	1.000
280	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(5), DIAPH1(7), GSN(4), HRAS(1), ITGA1(7), MYLK(13), PIK3CA(4), PIK3R1(1), PTK2(10), PXN(1), ROCK1(5), SHC1(1), SRC(2), TLN1(12)	8260745	73	31	67	12	18	16	10	9	19	1	0.0167	0.972	1.000
281	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	GNAQ(1), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(2), PPP3CC(1), SP1(1), SP3(1), SYT1(2)	4649800	23	7	23	5	5	7	2	3	5	1	0.159	0.972	1.000
282	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(5), TH(1), TPH1(2)	1350803	9	3	9	5	3	0	3	1	1	1	0.786	0.972	1.000
283	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ADC(1), ALDH4A1(3), ALDH5A1(2), CAD(6), CPS1(4), EARS2(1), EPRS(1), GAD1(5), GAD2(7), GCLC(1), GCLM(1), GFPT1(2), GFPT2(2), GLS(2), GLUD2(3), GOT1(2), GPT(1), GPT2(2), GSR(1), NADSYN1(4), NAGK(1), PPAT(2), QARS(2)	8743496	58	19	58	13	10	12	16	7	11	2	0.117	0.973	1.000
284	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPT(1), ENPP3(3), FLAD1(1), MTMR2(2), MTMR6(2), PHPT1(1), RFK(1), TYR(4)	3321331	16	6	16	5	7	4	3	1	1	0	0.527	0.973	1.000
285	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(2), CRKL(1), HRAS(1), JAK2(6), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), SOS1(2), STAT1(3), STAT5A(1)	6211567	32	15	31	8	7	2	6	9	8	0	0.495	0.974	1.000
286	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNGR1(2), JAK1(1), JAK2(6), PTPRU(6), REG1A(1), STAT1(3)	2525406	20	11	18	7	7	0	5	2	6	0	0.773	0.974	1.000
287	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1766118	6	4	6	2	4	0	2	0	0	0	0.558	0.975	1.000
288	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2)	1766118	6	4	6	2	4	0	2	0	0	0	0.558	0.975	1.000
289	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(3), MEF2D(2), PPARA(1), PPP3CA(2), PPP3CC(1), SYT1(2), YWHAH(1)	4523484	23	10	23	5	4	5	5	3	5	1	0.193	0.975	1.000
290	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1), SYT1(2)	3050552	9	4	9	5	0	2	1	2	3	1	0.821	0.977	1.000
291	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD3E(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(2), THY1(1)	2354390	12	4	12	3	6	1	0	2	3	0	0.273	0.977	1.000
292	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CDC34(1), CUL1(2), RB1(3), SKP2(3), TFDP1(1)	1906489	14	6	14	8	3	4	3	3	1	0	0.892	0.977	1.000
293	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), FBP2(1), GOT1(2), GPT(1), GPT2(2), ME1(2), ME3(1), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3)	4457095	23	8	23	3	4	8	8	2	1	0	0.0241	0.977	1.000
294	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CUL1(2), RB1(3), SKP2(3), TFDP1(1)	1899569	10	5	10	6	2	2	2	3	1	0	0.927	0.978	1.000
295	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(1), BAK1(1), CASP9(1), CES1(2)	2493077	8	2	8	2	2	3	3	0	0	0	0.468	0.978	1.000
296	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), EHHADH(2), HADHA(1)	2686698	9	5	9	3	5	0	3	0	1	0	0.491	0.979	1.000
297	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(3), ALDH5A1(2), CAD(6), CPS1(4), EPRS(1), GAD1(5), GAD2(7), GCLC(1), GCLM(1), GFPT1(2), GLS(2), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), PPAT(2), QARS(2)	7342170	49	15	49	11	9	10	12	6	10	2	0.147	0.979	1.000
298	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD3E(1), CD4(2), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(2), THY1(1)	2472258	14	4	14	4	6	1	0	3	4	0	0.383	0.979	1.000
299	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(2), FDPS(1), HMGCR(5), IDI1(1), LSS(1), MVD(2), MVK(1), NSDHL(2), SQLE(2)	2952807	18	7	17	6	6	6	4	0	2	0	0.375	0.979	1.000
300	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), ALAS2(3), CPO(2), HBB(1), HMBS(1)	1783537	8	6	8	4	4	1	1	0	2	0	0.789	0.980	1.000
301	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(2), ITPKB(3), MIOX(1), OCRL(1), PIK3C2A(5), PIK3C2B(10), PIK3CA(4), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7)	9993317	55	20	55	13	20	7	7	12	9	0	0.0921	0.980	1.000
302	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(3), CASP3(2), CASP9(1), DAXX(3), FASLG(1), MAPKAPK3(1)	2507784	14	4	14	2	3	5	2	2	2	0	0.137	0.981	1.000
303	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(2), EEF1G(2), EEF2(6), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(8), EIF4G3(5), EIF5(3), EIF5B(2), ETF1(1), PABPC1(9), PABPC3(5), SLC35A4(2)	9833824	64	27	58	13	12	12	15	9	16	0	0.198	0.981	1.000
304	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(4), ARHGEF1(2), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(3), MAP3K7(2), PIK3CA(4), PIK3R1(1), PLCB1(1), ROCK1(5)	5758882	25	12	25	7	4	7	4	6	4	0	0.342	0.982	1.000
305	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BIRC2(2), CASP10(4), CASP3(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), DFFB(1), GAS2(3), NFKBIA(1), RELA(2), SPTAN1(4), TNFRSF10A(2), TNFRSF10B(2), TNFSF12(1), TRADD(1), TRAF2(2)	7497621	38	15	38	7	11	7	5	2	13	0	0.101	0.982	1.000
306	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(2), GPRC5A(2), GPRC5B(5), GPRC5C(3), GRM1(9), GRM2(4), GRM3(2), GRM4(3), GRM5(7), GRM7(4), GRM8(4)	4616253	48	19	48	16	17	14	8	6	3	0	0.161	0.982	1.000
307	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(2), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), OGDH(5), OGDHL(1), PC(3), PCK1(3), PCK2(2), SDHA(3), SUCLA2(1), SUCLG1(3)	6570722	39	14	39	11	11	7	12	6	2	1	0.217	0.983	1.000
308	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(4), CSF1(2), IL1B(1), IL6R(1), SELL(1), TGFB1(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1), TNFSF8(3)	3013921	19	7	19	8	6	1	4	5	3	0	0.608	0.983	1.000
309	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(1), EPX(4), GOT1(2), HPD(3), LPO(5), MPO(2), PRDX1(1), TAT(1), TPO(7)	4880382	37	13	37	7	18	6	8	3	2	0	0.0187	0.983	1.000
310	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2RL3(1), GNAI1(1), GNB1(3), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(1), PTK2(10), SRC(2), SYK(2), TBXAS1(1)	5396162	30	11	27	9	6	8	3	4	9	0	0.664	0.983	1.000
311	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ARG2(1), ASL(2), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(4), OAT(2), ODC1(1), PYCR1(1)	3942723	21	5	21	2	7	3	6	3	1	1	0.0337	0.983	1.000
312	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(7), AXIN1(3), CCND2(3), CCND3(1), CSNK1E(1), CTNNB1(7), DVL1(4), DVL2(4), DVL3(1), FBXW2(1), FOSL1(1), FZD1(5), FZD10(6), FZD2(2), FZD3(3), FZD7(2), FZD8(1), FZD9(2), GSK3B(2), LDLR(1), MAPK9(1), PAFAH1B1(1), PLAU(1), PPP2R5C(3), PPP2R5E(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(4), PRKCQ(2), RHOA(1), SFRP4(1), TCF7(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2)	13542061	100	41	98	29	44	23	11	16	6	0	0.0151	0.984	1.000
313	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(7), AXIN1(3), CD14(1), CTNNB1(7), DVL1(4), FZD1(5), GJA1(1), GNAI1(1), GSK3B(2), LBP(1), LEF1(2), LY96(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(2), TLR4(1), WNT1(1)	6872038	46	16	46	7	13	8	8	15	2	0	0.0190	0.984	1.000
314	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(2), AKT3(2), BCR(2), BTK(1), CD19(1), CDKN2A(31), DAPP1(2), FLOT1(1), FLOT2(1), GAB1(1), ITPR1(10), ITPR2(4), ITPR3(8), PDK1(1), PHF11(1), PIK3CA(4), PLCG2(7), PREX1(8), PTPRC(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), SAG(1), SYK(2), TEC(2), VAV1(4)	12352205	104	52	92	21	26	13	14	16	34	1	0.0179	0.984	1.000
315	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), IL1R1(2), JUND(1), MYOG(2), NR4A3(1), WDR1(2)	2439293	16	4	15	5	5	2	1	5	3	0	0.481	0.985	1.000
316	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(3), CD3E(1), CD4(2), IL12B(1), JAK2(6), STAT4(1), TYK2(2)	3277872	16	7	15	5	2	1	3	2	8	0	0.814	0.985	1.000
317	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(2), IARS(4), ILVBL(2), LARS2(1), PDHA1(2), PDHA2(2), VARS(3), VARS2(2)	4099051	19	7	19	6	8	4	3	2	2	0	0.469	0.985	1.000
318	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY6(3), ADCY8(4), CACNA1A(8), CACNA1B(13), GNAS(12), GNB1(3), GNB3(2), GRM4(3), ITPR3(8), KCNB1(5), PLCB2(4), PRKACB(1), PRKACG(3), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS1R2(3), TAS1R3(2), TAS2R1(3), TAS2R10(1), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R4(1), TAS2R41(1), TAS2R42(1), TAS2R50(1), TAS2R60(1), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(1)	12992431	106	38	101	22	44	15	16	12	19	0	0.00132	0.986	1.000
319	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(2), DAXX(3), ELK1(2), HRAS(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K5(1), MAP3K7(2), MAP3K9(6), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2C(3), MEF2D(2), RPS6KA5(2), SHC1(1), STAT1(3), TGFB1(1), TGFBR1(8), TRADD(1), TRAF2(2)	8186760	55	28	54	14	16	9	11	7	12	0	0.222	0.986	1.000
320	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(3), DFFB(1), HMGB2(1), NME1(1), PRF1(1), SET(1)	2356964	8	4	8	3	2	2	2	1	1	0	0.569	0.986	1.000
321	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	ABAT(2), ACADS(1), ACAT1(2), ACAT2(1), ACSM1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(2), BDH1(1), BDH2(1), DDHD1(3), EHHADH(2), GAD1(5), GAD2(7), HADH(1), HADHA(1), HMGCS2(2), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(2), OXCT1(2), OXCT2(1), PDHA1(2), PDHA2(2), PLA1A(2), RDH11(2)	9011891	58	23	58	10	14	12	14	8	9	1	0.0155	0.987	1.000
322	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(2), C1GALT1(1), GALNT1(3), GALNT10(5), GALNT13(2), GALNT2(3), GALNT5(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1), WBSCR17(2)	7125760	40	19	39	9	11	6	10	4	9	0	0.216	0.987	1.000
323	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(3), ANXA6(3), CYP11A1(1), EDN1(1), EDNRB(2), HSD11B1(1), PRL(6), PTGDR(2), PTGDS(3), PTGFR(2), PTGIS(2), PTGS1(1), TBXAS1(1)	4627481	28	11	28	8	10	2	6	6	4	0	0.391	0.987	1.000
324	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(3), GLB1(2), LCT(5), NEU4(1), PPAP2B(2), PPAP2C(1), SMPD1(2), SPTLC1(3), SPTLC2(1), UGCG(1)	5436401	29	13	29	9	10	7	2	2	7	1	0.202	0.989	1.000
325	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(2), CASP10(4), CASP3(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), PRF1(1), SCAP(3), SREBF1(1), SREBF2(2)	4148220	23	8	23	5	5	6	2	1	9	0	0.208	0.989	1.000
326	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(5), NT5C(1), NT5E(1), NT5M(1)	3214431	19	5	19	5	5	4	5	3	2	0	0.318	0.989	1.000
327	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(7), AXIN1(3), BTRC(2), CREBBP(3), CSNK1D(1), CSNK2A1(1), CTNNB1(7), DVL1(4), FZD1(5), GSK3B(2), MAP3K7(2), NLK(2), PPARD(1), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1)	6633366	46	16	46	8	13	9	10	11	3	0	0.0262	0.990	1.000
328	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), BIRC2(2), CASP1(1), CASP10(4), CASP2(3), CASP3(2), CASP4(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), LMNB2(1), PRF1(1)	4274089	24	8	24	3	5	6	5	1	7	0	0.0849	0.990	1.000
329	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(4), APC(7), AXIN1(3), BTRC(2), CTNNB1(7), DLL1(2), DVL1(4), FZD1(5), GSK3B(2), NOTCH1(9), PSEN1(1), WNT1(1)	4881109	47	15	47	10	15	14	6	9	3	0	0.0273	0.990	1.000
330	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(3), ASRGL1(1), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(4), GLS(2), GLUD2(3), HAL(1)	4690180	20	7	20	6	5	8	2	1	3	1	0.386	0.990	1.000
331	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(1), GSK3B(2), IGF1R(6), INPPL1(2), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1)	4366285	21	10	21	9	4	3	3	6	5	0	0.813	0.990	1.000
332	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG7(2), BECN1(2), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(2), PRKAA2(1), ULK1(3), ULK3(1)	4723702	23	9	23	5	6	5	1	7	4	0	0.234	0.990	1.000
333	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(2), GOT1(2), LDHAL6A(1), LDHAL6B(2), LDHB(1), SULT1B1(1), SULT1C4(1), SULT4A1(1)	2787034	11	4	11	5	1	2	2	3	3	0	0.863	0.991	1.000
334	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ACAT1(2), ACAT2(1), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(2), GRHPR(1), HAGH(2), LDHB(1), ME1(2), ME2(6), ME3(1), PC(3), PCK1(3), PDHA1(2), PDHA2(2), PKLR(2)	8155021	47	17	47	8	10	18	6	3	10	0	0.0152	0.991	1.000
335	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(4), ERBB4(6), NRG2(1), PSEN1(1)	2007670	12	4	12	5	1	5	1	3	2	0	0.778	0.991	1.000
336	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(3), AGT(1), ANPEP(3), CMA1(1), CPA3(1), CTSA(1), CTSG(2), ENPEP(3), LNPEP(2), MME(2), NLN(1), REN(3), THOP1(1)	4677188	26	9	26	6	4	8	7	5	1	1	0.147	0.991	1.000
337	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(1), DDX20(1), E2F4(3), ETS1(2), ETS2(2), HDAC5(2), HRAS(1), NCOR2(3), RBL1(2), RBL2(6), SIN3A(4)	5893812	29	11	28	8	5	6	7	5	6	0	0.347	0.991	1.000
338	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), RELA(2), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(3), TRAF2(2), TRAF5(1), TRAF6(1)	3248040	14	5	14	4	2	2	5	1	4	0	0.636	0.992	1.000
339	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), B3GNT7(1), B4GALT2(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	2799190	15	6	15	2	5	1	6	2	1	0	0.0916	0.992	1.000
340	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(2), ARSE(1), CYP11B1(4), CYP11B2(1), HSD11B1(1), HSD17B2(2), HSD3B1(2), STS(4), SULT2A1(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1)	6032020	29	13	29	8	10	8	4	3	4	0	0.194	0.992	1.000
341	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT2(2), AKT3(2), ARHGEF11(6), CDC42(1), DLG4(3), LPA(8), MAP2K4(5), MAP3K1(3), MAP3K5(1), MAPK8(2), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(5), PIK3CB(1), PLD2(4), PTK2(10), RDX(4), ROCK1(5), ROCK2(2), SRF(1), TBXA2R(2)	10924762	73	32	68	17	12	13	14	14	20	0	0.175	0.992	1.000
342	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), IL12B(1), IL6(1), IL7(1), TGFB1(1)	2969618	8	2	8	4	1	2	1	3	1	0	0.783	0.992	1.000
343	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(1), ACPT(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), CYP3A5(1), CYP3A7(2), DHRS1(1), DHRS2(2), DHRS3(2), PON1(1), PON2(1)	4009188	23	7	23	7	10	4	2	5	2	0	0.282	0.993	1.000
344	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(4), CASP3(2), CASP7(1), CASP8(2), CFLAR(3), DAXX(3), DFFB(1), FAF1(1), LMNB2(1), MAP2K4(5), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK2(2), PRKDC(7), PTPN13(4), RB1(3), SPTAN1(4)	9224417	50	17	50	11	9	5	10	13	13	0	0.270	0.993	1.000
345	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GLB1(2), GNS(1), GUSB(1), HEXA(2), HEXB(2), LCT(5), NAGLU(2)	3252120	17	9	17	9	4	3	2	2	5	1	0.859	0.993	1.000
346	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(2), DBH(1), DCT(4), DDC(1), GOT1(2), HGD(2), HPD(3), TAT(1), TH(1), TPO(7), TYR(4)	7026328	53	16	53	17	24	8	10	6	5	0	0.169	0.993	1.000
347	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(3), JAK1(1), STAT1(3), STAT2(1), TYK2(2)	2399570	12	7	12	5	4	0	4	3	1	0	0.775	0.993	1.000
348	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(1), BDKRB2(1), CHRM1(1), CHRNA1(4), FLT1(3), FLT4(9), KDR(1), NOS3(8), PDE2A(1), PDE3A(8), PDE3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(15), SLC7A1(1), SYT1(2), TNNI1(1)	9115084	71	32	71	13	30	10	13	6	11	1	0.00234	0.993	1.000
349	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(1), ASL(2), ASS1(1), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(2), EPRS(1), GLUD2(3), GOT1(2), LAP3(1), NOS1(7), NOS3(8), OAT(2), P4HA1(4), P4HA2(1), P4HA3(1), PARS2(1), PRODH(2), PYCR1(1), RARS(1), RARS2(3)	8003984	60	20	60	11	21	9	17	8	4	1	0.0175	0.994	1.000
350	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(7), AXIN1(3), CREBBP(3), CTNNB1(7), DVL1(4), EP300(6), FZD1(5), GSK3B(2), LDB1(2), LEF1(2), TRRAP(11), WNT1(1)	7360120	53	16	53	11	19	9	8	13	3	1	0.0331	0.994	1.000
351	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3E(1), ETV5(2), IL12B(1), JAK2(6), MAP2K6(3), MAPK8(2), STAT4(1), TYK2(2)	4147405	18	8	17	5	3	1	4	1	9	0	0.588	0.994	1.000
352	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	MTNR1A(2), MTNR1B(2), PTGDR(2), PTGFR(2), TBXA2R(2)	2564039	10	5	10	8	2	2	4	0	2	0	0.901	0.994	1.000
353	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(5), ABCB11(2), ABCB4(1), ABCC1(1), ABCC3(2), GSTP1(1)	3157488	12	6	12	3	1	3	3	4	1	0	0.416	0.995	1.000
354	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), CMA1(1), COL4A1(4), COL4A2(6), COL4A3(2), COL4A4(4), COL4A5(3), COL4A6(4), REN(3)	5604442	31	11	31	4	6	7	13	2	2	1	0.0587	0.995	1.000
355	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLB(1), POLD1(2), POLG(4), RRM1(1)	2853640	15	4	15	4	4	6	1	1	3	0	0.190	0.995	1.000
356	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(2), HS2ST1(1), HS3ST2(3), HS6ST1(2), HS6ST2(1), NDST1(3), NDST3(3), NDST4(2)	4666888	36	12	35	9	13	5	10	3	5	0	0.188	0.995	1.000
357	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(3), CASP3(2), CASP8(2), CRADD(2), DFFB(1), LMNB2(1), MADD(3), MAP2K4(5), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK2(2), PRKDC(7), RB1(3), SPTAN1(4), TNFRSF1A(2), TRADD(1), TRAF2(2)	8760411	47	15	47	8	13	3	11	9	11	0	0.0815	0.995	1.000
358	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2M1(1), DNM1(2), EPN1(1), EPS15(2), NME1(1), PICALM(1), PPP3CA(2), PPP3CC(1), SYNJ1(1), SYNJ2(3), SYT1(2)	4944769	21	8	21	7	4	5	3	4	4	1	0.411	0.995	1.000
359	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), FDFT1(2), FDPS(1), GGCX(2), HMGCR(5), IDI1(1), LSS(1), MVD(2), MVK(1), NSDHL(2), SQLE(2), VKORC1(3)	4306138	23	9	22	7	8	6	6	1	2	0	0.283	0.996	1.000
360	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(1), EIF2B2(2), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(3), FLT4(9), HIF1A(1), HRAS(1), KDR(1), NOS3(8), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(10), PXN(1), SHC1(1)	7562406	47	21	44	12	13	9	11	3	11	0	0.274	0.996	1.000
361	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(6), ARHGEF5(2), ARPC1A(1), ARPC2(1), BAIAP2(3), DIAPH1(7), GSN(4), MYLK(13), PIP5K1B(2), ROCK1(5), SRC(2), TLN1(12), VCL(1)	10211844	70	27	67	18	19	17	11	9	13	1	0.0799	0.996	1.000
362	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(1), PSMB1(1), PSMB4(4), PSMB5(2), PSMB7(1), PSMD1(3), PSMD11(1), PSMD12(2), PSMD2(1)	3510857	20	10	20	9	6	1	5	4	4	0	0.858	0.996	1.000
363	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPO(2), EPOR(2), HRAS(1), JAK2(6), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(1), SOS1(2), STAT5A(1)	4795414	25	9	24	5	7	3	4	3	8	0	0.269	0.997	1.000
364	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4)	2253296	9	4	9	5	2	2	3	1	1	0	0.892	0.997	1.000
365	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(1), ACTN1(1), ACTN2(4), ACVR1B(2), ACVR1C(1), BAIAP2(3), CDC42(1), CDH1(1), CREBBP(3), CSNK2A1(1), CTNNA1(4), CTNNA2(5), CTNNA3(5), CTNNB1(7), CTNND1(2), EGFR(2), EP300(6), ERBB2(6), FARP2(3), FER(7), FGFR1(1), IGF1R(6), INSR(4), IQGAP1(2), LEF1(2), LMO7(4), MAP3K7(2), MET(4), MLLT4(4), NLK(2), PARD3(4), PTPN6(4), PTPRB(12), PTPRF(4), PTPRJ(2), PTPRM(7), PVRL1(2), PVRL2(1), PVRL3(1), RAC2(1), RHOA(1), SMAD2(1), SMAD4(32), SORBS1(2), SRC(2), SSX2IP(3), TCF7(1), TCF7L1(4), TCF7L2(1), TGFBR1(8), TGFBR2(10), TJP1(6), VCL(1), WASF1(1), WASF2(1), WASF3(1), WASL(2), YES1(1)	26540233	212	75	208	36	57	39	31	37	47	1	1.53e-05	0.997	1.000
366	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(1), RELA(2), TNFRSF1A(2), TRADD(1), TRAF2(2)	5452677	36	12	36	10	10	7	8	5	6	0	0.244	0.997	1.000
367	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLRMT(2)	3027677	16	9	15	6	8	3	1	2	2	0	0.531	0.997	1.000
368	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(5), MANBA(1), NEU4(1)	3721098	16	8	16	7	5	2	4	0	4	1	0.742	0.997	1.000
369	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(2), GPI(3), HK1(4), HK2(6), HK3(4), LDHAL6B(2), LDHB(1), PC(3), PCK1(3), PDHA1(2), PDHA2(2), PFKL(2), PFKM(3), PGAM1(2), PGK1(3), PKLR(2), TPI1(3)	9356928	61	24	61	13	24	15	9	4	9	0	0.0150	0.997	1.000
370	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL6(1), FADS1(1), FASN(6), HADHA(1), HSD17B12(1), SCD(1)	3288556	16	5	16	4	5	3	4	0	3	1	0.166	0.997	1.000
371	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(3), SH3GLB1(1)	5502769	27	7	27	9	8	7	3	5	4	0	0.461	0.997	1.000
372	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(1), ACOT11(1), DHRS1(1), DHRS2(2), DHRS3(2), EHHADH(2), ESCO1(3), GCDH(2), HADHA(1), SH3GLB1(1)	5725631	18	7	18	5	5	3	3	3	4	0	0.423	0.997	1.000
373	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(3), ABCG2(1), BCHE(6), CES1(2), CYP3A5(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1)	4986405	22	13	22	6	3	5	3	5	4	2	0.429	0.997	1.000
374	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSE(1), CARM1(2), CYP11B1(4), CYP11B2(1), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD3B1(2), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2), STS(4), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	11073772	60	25	58	13	15	18	12	9	6	0	0.0342	0.997	1.000
375	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(4), ACADL(2), ACADM(1), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(2), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3)	7287575	33	11	33	6	8	7	6	6	6	0	0.122	0.998	1.000
376	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(1), CAPNS1(2), CAPNS2(2), EGF(5), EGFR(2), HRAS(1), ITGA1(7), MYLK(13), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(10), PXN(1), TLN1(12)	7306135	67	23	63	10	22	15	8	7	14	1	0.00283	0.998	1.000
377	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(2), ARFGEF2(3), CLTB(1), COPA(3), GBF1(3), GPLD1(2), KDELR3(1)	3565345	16	5	16	4	4	3	4	3	1	1	0.310	0.998	1.000
378	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(7), GAL3ST1(1), GALC(2), GBA(3), GLB1(2), LCT(5), NEU4(1), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD1(2), SMPD3(1), SMPD4(3), SPHK1(1), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(1)	8034516	45	20	43	14	18	9	4	7	6	1	0.121	0.998	1.000
379	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), BAD(1), CASP9(1), CDC42(1), CHUK(1), ELK1(2), HRAS(1), PIK3CA(4), PIK3R1(1), RALBP1(2), RALGDS(2), RELA(2), RHOA(1)	4287574	20	9	20	8	3	5	4	5	3	0	0.765	0.998	1.000
380	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKM(3), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), RBKS(1), RPE(2), RPIA(1), TAL1(1), TKT(1)	4525212	29	11	29	10	10	4	9	3	3	0	0.357	0.998	1.000
381	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(4), F2RL1(2), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(2), PLD2(4), PTK2(10), RASAL1(4), SRC(2), TEC(2), VAV1(4)	6139534	47	13	43	12	12	12	7	3	12	1	0.164	0.999	1.000
382	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), HRAS(1), IL3RA(2), JAK2(6), PTPN6(4), SHC1(1), SOS1(2), STAT5A(1)	3912203	19	8	18	6	6	2	3	3	5	0	0.617	0.999	1.000
383	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(1), EGF(5), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SRC(2)	4268259	21	7	21	4	4	7	5	3	2	0	0.158	0.999	1.000
384	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(1), BDKRB2(1), C1QA(1), C1QB(35), C1QC(1), C1R(1), C1S(6), C3(11), C3AR1(3), C4BPB(2), C5(2), C5AR1(1), C6(6), C7(4), C8A(4), C9(2), CD46(1), CD55(1), CD59(1), CFB(5), CFD(1), CFH(4), CFI(2), CR1(4), CR2(5), F10(4), F11(1), F12(2), F13A1(3), F13B(2), F5(8), F8(3), FGA(4), FGB(4), FGG(2), KLKB1(1), KNG1(1), MASP1(3), PLAT(2), PLAU(1), PLG(1), PROC(1), PROS1(2), SERPINA1(2), SERPINA5(1), SERPINC1(3), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(2), THBD(3), VWF(5)	20027080	170	68	135	40	36	23	31	24	56	0	0.137	0.999	1.000
385	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	HLA-A(2), KLRC3(3), PIK3CA(4), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4)	4102692	20	8	20	8	6	2	4	6	1	1	0.718	0.999	1.000
386	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(1), PIK3CA(4), PIK3R1(1), RB1(3), RELA(2), TFDP1(1)	4491226	19	8	19	8	3	3	6	5	2	0	0.844	0.999	1.000
387	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(6), ADCY9(4), ARF1(1), ARF3(1), ARF4(1), ARL4D(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(4), ATP6V0D2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), ERO1L(1), GNAS(12), PDIA4(1), PLCG1(1), PLCG2(7), SEC61A1(1), SEC61A2(2), SEC61B(1), SEC61G(1)	8223469	57	20	52	15	22	11	10	6	8	0	0.119	0.999	1.000
388	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT1(2), AGPAT3(2), AGPAT4(3), AGPS(1), CDIPT(3), CHAT(4), CPT1B(5), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(3), DGKZ(3), GPD1(1), GPD2(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(2), PCYT1B(1), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCB2(4), PLCG1(1), PLCG2(7), PPAP2B(2), PPAP2C(1)	11236203	67	21	67	18	22	8	15	10	12	0	0.126	0.999	1.000
389	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(2), MAP2K4(5), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(2), SMPD1(2), TNFRSF1A(2), TRADD(1), TRAF2(2)	4590463	23	10	23	8	6	2	5	4	6	0	0.713	0.999	1.000
390	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CHUK(1), DAXX(3), EGF(5), EGFR(2), ETS1(2), ETS2(2), HOXA7(1), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K5(1), MAPK13(1), MAPK8(2), NFKBIA(1), PPP2CA(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), RELA(2), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	10954512	60	23	60	18	14	12	13	11	10	0	0.230	0.999	1.000
391	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IKBKB(4), MAP3K1(3), MAP3K5(1), MAP4K5(1), MAPK8(2), NFKBIA(1), RELA(2), TNFRSF9(1), TRAF2(2)	4356040	18	7	18	7	2	4	4	4	4	0	0.716	0.999	1.000
392	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(3), CAMK1(2), CAMK1G(2), HDAC5(2), IGF1R(6), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(1), MEF2C(3), MEF2D(2), NFATC1(4), NFATC2(3), PIK3CA(4), PIK3R1(1), PPP3CA(2), PPP3CC(1), SYT1(2), YWHAH(1)	7749613	51	17	51	14	14	10	8	7	11	1	0.120	0.999	1.000
393	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(3), CA5B(1), CA6(3), CA8(1), CA9(1), CPS1(4), GLS(2), HAL(1)	4192355	16	4	16	5	4	6	1	1	3	1	0.482	0.999	1.000
394	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(4), POLL(2), POLQ(3)	3719114	21	5	21	3	7	5	5	1	3	0	0.0705	0.999	1.000
395	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	3329772	14	6	14	3	3	4	5	1	1	0	0.245	0.999	1.000
396	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	3329772	14	6	14	3	3	4	5	1	1	0	0.245	0.999	1.000
397	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	3329772	14	6	14	3	3	4	5	1	1	0	0.245	0.999	1.000
398	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	GNAQ(1), GNAS(12), GNB1(3), HRAS(1), NOX1(2), PLCB1(1), PTK2(10), ROCK2(2)	5646482	32	17	24	9	11	5	4	3	9	0	0.607	0.999	1.000
399	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(3), SH3GLB1(1)	3648848	9	4	9	4	2	1	1	3	2	0	0.793	0.999	1.000
400	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(6), COL4A3(2), COL4A4(4), COL4A5(3), COL4A6(4), SLC2A1(3), SLC2A3(1)	5602560	27	10	27	7	5	5	11	2	3	1	0.423	0.999	1.000
401	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), AKT1(1), ANGPTL2(1), CDC42(1), FLNA(10), FLNC(10), FSCN1(1), FSCN3(2), GDI1(1), GDI2(3), MYH2(3), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), ROCK1(5), ROCK2(2), WASF1(1), WASL(2)	10735657	69	31	68	21	18	13	15	12	10	1	0.246	0.999	1.000
402	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(2), FBP2(1), GCK(1), GMDS(1), GMPPA(3), HK1(4), HK2(6), HK3(4), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(3), PMM2(2), TPI1(3)	5311585	36	17	36	12	16	4	8	2	6	0	0.368	0.999	1.000
403	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(2), C6(6), C7(4), ICAM1(2), IL6(1), ITGA4(1), ITGAL(2), ITGB2(1), SELP(2), SELPLG(1)	5451277	33	14	33	12	10	8	6	2	7	0	0.414	0.999	1.000
404	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(2), BCAT1(1), BCKDHA(1), BCKDHB(1), EHHADH(2), HADHA(1), HADHB(2), HIBADH(2), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2)	7941114	40	12	40	6	9	10	8	3	10	0	0.0239	0.999	1.000
405	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT2(1), FUT2(2), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(2), ST8SIA1(2)	3641425	17	6	17	3	8	5	4	0	0	0	0.0621	0.999	1.000
406	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ADC(1), ALDH18A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AMD1(1), AOC2(2), AOC3(3), ARG1(1), ARG2(1), ASL(2), ASS1(1), CPS1(4), ODC1(1), SAT2(1)	6562373	24	9	24	3	10	4	4	2	3	1	0.0297	0.999	1.000
407	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CANX(1), CD4(2), CD8B(2), CREB1(2), CTSB(2), CTSS(2), HLA-A(2), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), HSP90AA1(2), HSP90AB1(2), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL1(3), KIR2DL3(2), KIR3DL1(2), KLRC3(3), LGMN(1), NFYC(1), PDIA3(2), RFX5(1), TAP1(4), TAP2(1), TAPBP(1)	10352013	54	22	54	15	9	14	7	12	12	0	0.215	0.999	1.000
408	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), FDXR(1), SHMT1(1)	3541871	15	6	15	4	3	4	6	1	1	0	0.333	0.999	1.000
409	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC2(2), AOC3(3), CES1(2), DDHD1(3), ESCO1(3), LIPA(1), PLA1A(2), SH3GLB1(1)	5595333	17	8	17	5	5	3	5	3	1	0	0.423	0.999	1.000
410	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(1), RELA(2), TNFAIP3(2), TRAF6(1)	4035712	17	5	17	7	2	5	6	2	2	0	0.753	0.999	1.000
411	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(1), ELK1(2), IKBKB(4), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(2), NFKBIA(1), PPARA(1), RELA(2), TLR2(3), TLR3(2), TLR4(1), TLR6(4), TLR9(8), TRAF6(1)	8121143	48	18	48	12	13	6	7	10	12	0	0.245	0.999	1.000
412	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), CRK(1), CRKL(1), DOCK1(4), ELK1(2), GAB1(1), HGF(1), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PIK3CA(4), PIK3R1(1), PTK2(10), PXN(1), RAP1B(3), RASA1(2), SOS1(2), SRC(2), STAT3(2)	9940539	57	23	54	16	10	16	6	9	16	0	0.364	1.000	1.000
413	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(5), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(1), NT5M(1), NUDT12(1)	4765188	23	6	23	7	6	5	7	3	2	0	0.384	1.000	1.000
414	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(7), MAP2(5), PPP1CA(1), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAR2B(1), PRKCE(1)	3997752	20	6	20	9	6	4	3	5	2	0	0.836	1.000	1.000
415	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(8), ACAT1(2), ACAT2(1), ACOT12(4), ACSS2(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DLAT(4), GLO1(2), GRHPR(1), HAGH(2), LDHAL6A(1), LDHAL6B(2), LDHB(1), ME1(2), ME2(6), ME3(1), PC(3), PCK1(3), PCK2(2), PDHA1(2), PDHA2(2), PKLR(2)	10307851	62	22	62	13	16	19	7	4	14	2	0.0257	1.000	1.000
416	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(1), EPX(4), ESCO1(3), GOT1(2), HPD(3), LPO(5), MPO(2), SH3GLB1(1), TAT(1), TPO(7)	7573766	40	13	40	8	19	6	7	5	3	0	0.0296	1.000	1.000
417	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(4), HK2(6), HK3(4), LDHB(1), PDHA1(2), PDHA2(2), PFKM(3), PGAM1(2), PGK1(3), PGM1(1), PGM3(1), PKLR(2), TPI1(3)	10771003	74	23	74	19	32	15	11	5	11	0	0.0415	1.000	1.000
418	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(4), HK2(6), HK3(4), LDHB(1), PDHA1(2), PDHA2(2), PFKM(3), PGAM1(2), PGK1(3), PGM1(1), PGM3(1), PKLR(2), TPI1(3)	10771003	74	23	74	19	32	15	11	5	11	0	0.0415	1.000	1.000
419	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(3), CPOX(1), EPRS(1), GUSB(1), HMBS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1)	5994760	22	9	22	3	4	6	1	6	5	0	0.102	1.000	1.000
420	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), ASPA(1), DDC(1), HAL(1), PRPS1(1)	5404257	18	9	18	5	8	4	4	2	0	0	0.225	1.000	1.000
421	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(5), MAN2B1(1), MAN2B2(2), MANBA(1), NEU4(1)	4578523	19	9	19	9	7	2	5	0	4	1	0.758	1.000	1.000
422	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKL(2), PFKM(3), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), RBKS(1), RPE(2), RPIA(1), TKT(1)	5400825	30	10	30	9	11	5	9	3	2	0	0.199	1.000	1.000
423	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(4), ACACB(8), AKT1(1), AKT2(2), AKT3(2), ARAF(2), BAD(1), BRAF(3), CALML3(1), CBL(3), CBLB(2), CRK(1), CRKL(1), ELK1(2), EXOC7(1), FASN(6), FBP2(1), FLOT1(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(2), GYS1(3), GYS2(2), HRAS(1), IKBKB(4), INPP5D(1), INSR(4), IRS1(4), IRS2(4), IRS4(16), KRAS(127), LIPE(2), MAPK8(2), MAPK9(1), MKNK2(1), PCK1(3), PCK2(2), PDE3A(8), PDE3B(2), PFKL(2), PFKM(3), PHKA2(5), PHKB(3), PHKG1(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(4), PPP1R3C(2), PPP1R3D(1), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAG3(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(4), PTPRF(4), PYGL(2), PYGM(1), RHEB(1), RPS6KB2(1), SHC1(1), SHC2(2), SHC4(1), SOCS4(2), SORBS1(2), SOS1(2), SOS2(1), SREBF1(1), TRIP10(2), TSC1(2), TSC2(6)	36086943	331	132	197	79	63	98	87	34	47	2	2.86e-05	1.000	1.000
424	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(7), ASAH1(1), CAMP(2), CASP3(2), CERK(1), CREB1(2), CREB5(1), DAG1(1), EPHB2(4), GNAQ(1), ITPKB(3), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1)	6451420	42	15	42	10	12	5	7	9	9	0	0.180	1.000	1.000
425	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(4), ACACB(8), ACADM(1), ACAT1(2), ACAT2(1), ACSS2(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), EHHADH(2), HADHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3)	8733223	39	11	39	9	11	8	7	5	8	0	0.177	1.000	1.000
426	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), POLG(4), POLH(1), POLI(2), POLK(3), POLL(2), POLM(3), POLQ(3), PRIM1(1), REV1(1), REV3L(5)	9069477	44	13	41	6	8	7	9	10	10	0	0.0533	1.000	1.000
427	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH4A1(3), AMD1(1), AOC2(2), AOC3(3), ARG1(1), ARG2(1), ASL(2), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(2), GOT1(2), NOS1(7), NOS3(8), OAT(2), ODC1(1), P4HA1(4), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1)	9836916	61	20	61	8	25	10	16	6	3	1	0.000756	1.000	1.000
428	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(3), AR(2), ESR1(1), ESR2(2), ESRRA(2), NPM1(1), NR0B1(3), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), NR5A2(1), PGR(4), PPARA(1), PPARD(1), PPARG(1), RARB(1), RARG(2), ROR1(2), RORA(1), RORC(1), RXRA(1), RXRB(2), RXRG(1), THRA(1), THRB(1)	9479536	57	19	57	17	18	14	10	6	9	0	0.0918	1.000	1.000
429	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPT(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2D6(2), CYP2E1(1), CYP2F1(2), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(1), PON1(1)	6489338	48	17	47	15	19	6	10	7	6	0	0.229	1.000	1.000
430	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CARM1(2), CREBBP(3), EP300(6), ERCC3(3), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(2), GTF2F1(1), HDAC4(4), HDAC5(2), HDAC6(1), MEF2C(3), NCOR2(3), NR0B1(3), NRIP1(2), POLR2A(5), SRA1(2), TBP(1)	10464133	49	22	48	12	14	8	11	6	10	0	0.154	1.000	1.000
431	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(2), AKT3(2), CISH(1), IARS(4), IL4R(3), INPP5D(1), JAK1(1), JAK2(6), JAK3(3), PIK3CA(4), SHC1(1), SOS1(2), SOS2(1), SRC(2), STAT6(5), TYK2(2)	8215085	41	17	40	12	9	7	8	8	9	0	0.467	1.000	1.000
432	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT2(2), FUT9(1), GCNT2(2), ST8SIA1(2)	1385375	7	2	7	2	4	2	1	0	0	0	0.345	1.000	1.000
433	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(2), LDHB(1)	1511778	3	1	3	2	1	0	1	1	0	0	0.935	1.000	1.000
434	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(2), CARM1(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), MARS2(2), MAT2B(2), METTL2B(2), METTL6(1), PAPSS1(2), PAPSS2(6), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2), SCLY(2), SEPHS2(5)	5524346	40	18	38	14	12	9	10	2	7	0	0.470	1.000	1.000
435	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(3), EP300(6), IKBKB(4), NFKBIA(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	5006368	22	10	22	9	6	4	6	2	4	0	0.717	1.000	1.000
436	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3E(1), ELK1(2), HRAS(1), LCK(1), MAP2K4(5), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKBIA(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CC(1), PTPN7(1), RASA1(2), RELA(2), SHC1(1), SOS1(2), SYT1(2), VAV1(4), ZAP70(6)	10617358	59	16	59	14	14	14	8	11	10	2	0.104	1.000	1.000
437	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3A(1), POLR3B(3), POLR3G(1)	5143197	22	12	21	9	9	3	4	2	4	0	0.726	1.000	1.000
438	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), AKR1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), G6PC2(1), GAPDHS(2), GCK(1), GPI(3), HK1(4), HK2(6), HK3(4), LDHAL6A(1), LDHAL6B(2), LDHB(1), PDHA1(2), PDHA2(2), PFKL(2), PFKM(3), PGAM1(2), PGAM4(2), PGK1(3), PGM1(1), PGM3(1), PKLR(2), TPI1(3)	12852528	86	27	86	23	35	20	13	5	13	0	0.0349	1.000	1.000
439	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(2), SRP54(1), SRP68(4), SRP72(1), SRPR(1)	1649687	9	1	9	1	3	4	2	0	0	0	0.190	1.000	1.000
440	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), CAMP(2), DAG1(1), GNAQ(1), ITPKB(3)	1371427	8	1	8	1	3	0	1	2	2	0	0.215	1.000	1.000
441	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IKBKB(4), IL1B(1), IL1R1(2), IL1RAP(2), IL1RN(1), IL6(1), IRAK3(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(2), NFKBIA(1), RELA(2), TGFB1(1), TRAF6(1)	6613435	29	11	28	9	6	4	5	6	8	0	0.495	1.000	1.000
442	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), ASPA(1), CARM1(2), DDC(1), FTCD(3), HAL(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2), PRPS1(1), UROC1(3)	8796791	41	15	41	9	12	11	12	4	2	0	0.0450	1.000	1.000
443	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(7), AR(2), ASAH1(1), BRAF(3), CAMP(2), CCL16(1), DAG1(1), EGFR(2), GNA11(2), GNA15(3), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), KCNJ5(1), PHKA2(5), PIK3CA(4), PIK3CD(2), PIK3R1(1), SRC(2)	11948780	67	24	67	13	21	9	15	11	11	0	0.0237	1.000	1.000
444	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ARPC5(1), ARPC5L(1), CD14(1), CDC42(1), CDH1(1), CTNNB1(7), CTTN(2), HCLS1(1), LY96(1), NCK1(4), NCK2(2), RHOA(1), ROCK1(5), ROCK2(2), TLR4(1), TLR5(2), TUBA1A(2), TUBA1B(1), TUBA3C(3), TUBA3D(3), TUBA3E(4), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(1), TUBB3(2), TUBB6(1), TUBB8(2), WASL(2)	11624431	68	22	68	17	25	16	8	13	6	0	0.0333	1.000	1.000
445	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(5), ACTB(1), ARPC5(1), ARPC5L(1), CD14(1), CDC42(1), CDH1(1), CTNNB1(7), CTTN(2), HCLS1(1), LY96(1), NCK1(4), NCK2(2), RHOA(1), ROCK1(5), ROCK2(2), TLR4(1), TLR5(2), TUBA1A(2), TUBA1B(1), TUBA3C(3), TUBA3D(3), TUBA3E(4), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(1), TUBB3(2), TUBB6(1), TUBB8(2), WASL(2)	11624431	68	22	68	17	25	16	8	13	6	0	0.0333	1.000	1.000
446	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(8), FASN(6), MCAT(1), OXSM(1)	3612743	20	3	20	4	7	5	4	1	2	1	0.0778	1.000	1.000
447	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA1(1), ACADM(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(1), AOX1(2), AUH(1), BCAT1(1), BCAT2(2), BCKDHA(1), BCKDHB(1), DBT(3), EHHADH(2), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HMGCS2(2), HSD17B4(3), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2), OXCT2(1)	9522404	49	16	49	10	13	9	11	4	12	0	0.0753	1.000	1.000
448	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(2), MAP3K1(3), NCOR2(3), RXRA(1), THRA(1), THRB(1)	3880008	16	7	16	9	2	5	5	2	2	0	0.904	1.000	1.000
449	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(1), AKT2(2), AKT3(2), APC(7), AXIN1(3), AXIN2(1), CTNNB1(7), DACT1(4), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(2), LRP1(15), MVP(2), NKD1(4), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(2), WIF1(2)	9101459	65	24	65	14	24	13	12	12	4	0	0.0197	1.000	1.000
450	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(2), AKT3(2), ASAH1(1), BRAF(3), DAG1(1), EGFR(2), EPHB2(4), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), RGS20(1), SHC1(1), SOS1(2), SOS2(1), SRC(2), STAT3(2), TERF2IP(1)	13038551	64	22	64	16	20	9	12	11	12	0	0.134	1.000	1.000
451	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), CITED2(1), CPT1B(5), CREBBP(3), DUT(1), EHHADH(2), EP300(6), HSD17B4(3), LPL(3), ME1(2), NCOR1(11), NCOR2(3), NFKBIA(1), NR1H3(3), NR2F1(2), NRIP1(2), PIK3CA(4), PIK3R1(1), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RB1(3), RELA(2), RXRA(1), SP1(1), SRA1(2), STAT5A(1)	14077897	73	25	72	19	22	16	12	10	13	0	0.0900	1.000	1.000
452	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), NFAT5(4), PDE6B(3), PDE6C(1), PDE6G(1), SLC6A13(2)	7991713	38	12	38	7	13	7	9	2	7	0	0.0419	1.000	1.000
453	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(3), AGT(1), AKT1(1), CAMK1(2), CAMK1G(2), CAMK4(1), CREBBP(3), EDN1(1), ELSPBP1(2), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(2), HAND2(1), HRAS(1), LIF(1), MAPK8(2), MEF2C(3), MYH2(3), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NKX2-5(1), PIK3CA(4), PIK3R1(1), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SYT1(2)	11267060	65	18	65	15	22	12	12	9	9	1	0.0282	1.000	1.000
454	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(1), RPL10A(1), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL28(2), RPL32(1), RPL34(1), RPL35(1), RPL36AL(1), RPL3L(2), RPL6(1), RPS11(2), RPS12(1), RPS25(1), RPS27(1), RPS28(1), RPSA(1)	5045008	29	13	29	7	9	3	9	0	8	0	0.336	1.000	1.000
455	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), ELK1(2), FCER1A(1), HRAS(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CC(1), SHC1(1), SOS1(2), SYK(2), SYT1(2), VAV1(4)	9519845	54	14	54	15	13	13	7	11	8	2	0.228	1.000	1.000
456	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(2)	1498144	18	4	18	3	7	7	0	2	2	0	0.0217	1.000	1.000
457	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKBIA(1), PLCB1(1), RELA(2)	1824847	5	2	5	3	1	1	1	1	1	0	0.906	1.000	1.000
458	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(1), ACOX1(1), ACOX3(2), ACSL1(1), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A22(1), EHHADH(2), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3)	10789272	68	19	68	13	23	17	11	7	10	0	0.00542	1.000	1.000
459	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), NAT2(1), XDH(5)	1742972	16	6	16	7	8	1	1	4	2	0	0.690	1.000	1.000
460	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(2), FLT3(3), IL6(1), IL9(1), TGFB1(1)	1849465	9	3	9	2	2	2	4	1	0	0	0.347	1.000	1.000
461	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), ALAS2(3), BLVRA(2), COX15(1), CP(3), CPOX(1), EARS2(1), EPRS(1), FTMT(3), GUSB(1), HMBS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	9263720	40	16	39	8	8	13	2	9	8	0	0.0820	1.000	1.000
462	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(3), BIRC2(2), CASP2(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CRADD(2), DAXX(3), DFFB(1), GSN(4), LMNB2(1), MAP2K7(3), MAP3K1(3), MAP3K5(1), MAPK8(2), MDM2(2), NFKBIA(1), NUMA1(3), PAK2(2), PRKCD(4), PRKDC(7), PSEN1(1), PSEN2(1), PTK2(10), RASA1(2), RB1(3), RELA(2), SPTAN1(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(2)	15537234	86	27	81	19	16	12	23	11	24	0	0.122	1.000	1.000
463	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(1), EDN1(1), EDNRB(2), EGF(5), EGFR(2), HRAS(1), PLCG1(1), RELA(2)	4533841	17	5	17	6	3	4	4	1	5	0	0.601	1.000	1.000
464	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(1), B4GALT2(1), FUT2(2), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(2), PIGB(2), PIGC(1), PIGG(2), PIGL(2), PIGM(1), PIGO(4), PIGQ(6), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3), UGCG(1)	10888579	64	25	64	14	20	13	16	6	9	0	0.0120	1.000	1.000
465	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(3), ENPP3(3), GAA(2), GANAB(3), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(4), HK2(6), HK3(4), MGAM(3), PGM1(1), PGM3(1), PYGL(2), PYGM(1), SI(5), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1), UXS1(2)	12615090	71	31	70	19	24	15	10	8	14	0	0.170	1.000	1.000
466	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(3), AVPR1A(1), AVPR1B(1), AVPR2(2), BDKRB2(1), C3AR1(3), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR4(3), CCR7(1), CX3CR1(1), CXCR4(3), EDNRB(2), FPR1(2), FSHR(3), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC5R(3), NPY1R(3), NPY2R(2), NPY5R(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(1), OXTR(2), SSTR1(2), SSTR4(3), TACR1(3), TACR2(1), TACR3(2), TRHR(2), TSHR(3)	11608086	83	28	81	29	32	12	19	10	9	1	0.143	1.000	1.000
467	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2)	1764957	8	3	8	2	3	0	4	1	0	0	0.496	1.000	1.000
468	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CYP2C9(2), DHRS1(1), DHRS2(2), DHRS3(2), EHHADH(2), ESCO1(3), HADHA(1), SH3GLB1(1)	6824087	20	9	20	8	8	2	4	3	3	0	0.643	1.000	1.000
469	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(2), FBP2(1), FUK(1), GMDS(1), GMPPA(3), HK1(4), HK2(6), HK3(4), HSD3B7(3), MTMR2(2), MTMR6(2), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKL(2), PFKM(3), PGM2(1), PHPT1(1), PMM2(2), RDH11(2), TPI1(3), TSTA3(1)	8300064	51	22	51	17	20	6	13	5	7	0	0.402	1.000	1.000
470	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), AKR1C1(1), AKR1C3(2), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A5(1), CYP3A7(2), EPHX1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1)	12708372	79	22	78	22	22	19	15	12	11	0	0.103	1.000	1.000
471	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ADAM17(4), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(4), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), CASP3(2), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(3), IGSF5(1), IKBKB(4), JAM2(2), MAP2K4(5), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(1), NOD1(3), PLCG1(1), PLCG2(7), PTPRZ1(4), RELA(2), SRC(2), TCIRG1(1), TJP1(6)	15609213	82	26	82	18	16	20	18	14	14	0	0.0312	1.000	1.000
472	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(5), MAP2K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SYT1(2), TRAF2(2), TRAF5(1), TRAF6(1)	7676257	38	14	38	12	7	9	8	7	6	1	0.304	1.000	1.000
473	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(1), ACTN2(4), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(2), CAPNS2(2), CRKL(1), CSK(1), HRAS(1), ITGA1(7), MAPK8(2), PTK2(10), PXN(1), ROCK1(5), SHC1(1), SOS1(2), SRC(2), TLN1(12), VCL(1), ZYX(1)	10594517	64	22	61	12	21	17	6	6	13	1	0.0133	1.000	1.000
474	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(1), GSK3B(2), PFKL(2), PFKM(3), PLCG1(1), PRKCE(1)	5667293	19	5	19	7	4	8	3	2	2	0	0.373	1.000	1.000
475	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3E(1), HLA-A(2), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(1)	1915653	9	2	9	3	4	1	1	1	2	0	0.392	1.000	1.000
476	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(2), DIAPH2(1), MCM10(1), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), NACA(8), POLA2(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), PRIM1(1), RFC1(3), RFC2(2), RPA1(1), RPA2(2), RPA3(1), RPS27A(1), UBB(1)	11262089	62	20	60	10	20	7	15	8	11	1	0.0130	1.000	1.000
477	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(2), CARM1(2), DBH(1), DCT(4), DDC(1), ESCO1(3), GOT1(2), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2), SH3GLB1(1), TAT(1), TH(1), TPO(7), TYR(4), TYRP1(1)	13161772	78	22	78	23	29	15	18	9	7	0	0.120	1.000	1.000
478	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(3), SOAT1(1)	7057317	42	11	42	15	13	9	11	5	4	0	0.432	1.000	1.000
479	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), ATP7A(4), ATP7B(1), COX4I1(1), COX6A1(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), NDUFV2(3), SDHA(3), SHMT1(1), UQCRB(1), UQCRFS1(1)	8449224	44	18	43	14	10	10	9	10	4	1	0.380	1.000	1.000
480	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAD(1), CASP1(1), CASP10(4), CASP2(3), CASP3(2), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(3), DFFB(1), FASLG(1), IKBKE(1), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(4), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(2), TRAF6(1)	9771032	48	12	48	14	12	13	10	5	8	0	0.315	1.000	1.000
481	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(1), CDC42(1), CREB1(2), CREB5(1), DUSP10(2), ELK1(2), IL1R1(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K10(2), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), MKNK2(1), MYEF2(2), NR2C2(1), SRF(1), TRAF6(1)	7522489	38	21	37	13	7	5	8	5	13	0	0.701	1.000	1.000
482	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(1), AKT2(2), AKT3(2), DAG1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(5), PIK3CB(1), PLD2(4), VN1R1(1)	10048939	52	20	51	13	18	10	10	6	8	0	0.101	1.000	1.000
483	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(2), ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(1), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ANGPTL4(1), APOA5(3), AQP7(7), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A22(1), CYP7A1(2), CYP8B1(2), EHHADH(2), FABP4(1), GK2(4), HMGCS2(2), ILK(1), LPL(3), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(2), PLTP(1), PPARA(1), PPARD(1), PPARG(1), RXRA(1), RXRB(2), RXRG(1), SCD(1), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(3), SORBS1(2), UCP1(1)	14448619	96	33	95	18	29	25	18	9	13	2	0.000852	1.000	1.000
484	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), AANAT(1), ACAT1(2), ACAT2(1), AFMID(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(3), AOX1(2), ASMT(1), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(2), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), KMO(2), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(5), OGDHL(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2), TDO2(1), TPH1(2), TPH2(2), WARS(2)	13398768	76	23	76	19	24	12	21	8	11	0	0.0966	1.000	1.000
485	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(7), ASAH1(1), CAMP(2), DAG1(1), DLG4(3), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(4), ITPR3(8), KCNJ5(1), RYR1(23)	10259028	67	25	67	17	30	7	14	8	8	0	0.0545	1.000	1.000
486	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(3), ADRA1D(1), ADRA2A(1), ADRA2C(2), ADRB2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), DRD1(5), DRD5(2), HRH2(1), HTR1A(3), HTR1D(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(2), HTR5A(4), HTR7(1)	5787722	46	20	45	19	17	7	11	7	3	1	0.585	1.000	1.000
487	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT2(1), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(2), HK1(4), HK2(6), HK3(4), HSD3B7(3), LCT(5), MGAM(3), PFKL(2), PFKM(3), PGM1(1), PGM3(1), RDH11(2), UGP2(3)	8609684	46	21	46	16	19	6	7	4	9	1	0.417	1.000	1.000
488	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(2), ACVR1C(1), AKT1(1), AKT2(2), AKT3(2), ARRB1(1), ARRB2(2), BDNF(1), BRAF(3), CACNA1A(8), CACNA1B(13), CACNA1C(8), CACNA1D(10), CACNA1E(9), CACNA1F(4), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(5), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(3), CACNG3(2), CACNG4(1), CACNG5(4), CASP3(2), CD14(1), CDC25B(1), CDC42(1), CHUK(1), CRK(1), CRKL(1), DAXX(3), DUSP10(2), DUSP14(1), DUSP16(2), DUSP6(2), DUSP7(1), DUSP9(1), EGF(5), EGFR(2), ELK1(2), ELK4(2), FASLG(1), FGF10(1), FGF12(1), FGF13(2), FGF14(2), FGF18(1), FGF2(1), FGF23(1), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(3), FLNA(10), FLNB(4), FLNC(10), HRAS(1), IKBKB(4), IL1B(1), IL1R1(2), IL1R2(1), JUND(1), KRAS(127), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(2), MAP3K12(4), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(3), MAX(1), MEF2C(3), MKNK2(1), MOS(3), NF1(3), NFATC2(3), NFATC4(5), NFKB2(1), NLK(2), NR4A1(3), NTF3(4), NTRK1(2), NTRK2(3), PAK2(2), PDGFRA(3), PDGFRB(3), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PPM1B(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKCG(2), PTPN5(1), PTPN7(1), RAC2(1), RAP1B(3), RAPGEF2(6), RASA1(2), RASA2(2), RASGRF1(1), RASGRF2(2), RASGRP1(2), RASGRP2(1), RASGRP3(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(2), RPS6KA5(2), RPS6KA6(4), RRAS(2), SOS1(2), SOS2(1), SRF(1), STK3(1), STK4(1), STMN1(1), TAOK1(4), TAOK2(4), TGFB1(1), TGFBR1(8), TGFBR2(10), TNFRSF1A(2), TP53(100), TRAF2(2), TRAF6(1)	65118457	629	138	476	112	158	137	142	85	104	3	<1.00e-15	1.000	1.000
489	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CSK(1), CTLA4(1), DAG1(1), DTYMK(1), EPHB2(4), FBXW7(5), GRAP2(2), ITK(1), ITPKB(3), LCK(1), LCP2(3), NCK1(4), NFAT5(4), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), RASGRP3(2), SOS1(2), SOS2(1), VAV1(4), ZAP70(6)	12547437	65	20	63	18	19	15	9	8	12	2	0.219	1.000	1.000
490	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), AOC2(2), AOC3(3), AOX1(2), ASMT(1), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2D6(2), CYP2E1(1), CYP2F1(2), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(1), DDC(1), EHHADH(2), GCDH(2), HAAO(1), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2)	12144950	68	25	67	21	23	8	20	9	8	0	0.288	1.000	1.000
491	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DPYS(3), DTYMK(1), DUT(1), ITPA(1), NME1(1), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(4), POLL(2), POLQ(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLRMT(2), RRM1(1), TYMS(1), UMPS(2), UPB1(2)	12824445	67	21	66	19	21	17	12	9	8	0	0.0905	1.000	1.000
492	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(1), AKT2(2), AKT3(2), ANGPTL2(1), ARHGAP4(1), ARHGEF11(6), BTK(1), CDC42(1), GDI1(1), GDI2(3), INPPL1(2), ITPR1(10), ITPR2(4), ITPR3(8), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3CG(4), PIK3R1(1), RACGAP1(3), ROCK1(5), ROCK2(2), SAG(1), WASF1(1), WASL(2)	15643695	92	34	91	28	29	17	19	13	13	1	0.183	1.000	1.000
493	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), JAK1(1), PTPRU(6), REG1A(1), STAT1(3), STAT2(1), TYK2(2)	2763223	16	7	15	8	9	0	4	2	1	0	0.810	1.000	1.000
494	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(1), ANGPTL2(1), DAG1(1), DGKA(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), NR1I3(1), PDE3A(8), PDE3B(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), RIPK3(2), SGCB(1)	10895335	50	17	50	15	16	7	12	5	10	0	0.320	1.000	1.000
495	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(2), SCAP(3), SREBF1(1), SREBF2(2)	2756387	9	5	9	8	3	2	0	2	2	0	0.952	1.000	1.000
496	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(2), AKT3(2), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(2), CR2(5), CSK(1), DAG1(1), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(10), ITPR2(4), ITPR3(8), MAP4K1(3), NFATC1(4), NFATC2(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PTPRC(2), SHC1(1), SOS1(2), SOS2(1), SYK(2), VAV1(4)	16461341	90	26	90	21	29	20	13	15	12	1	0.0113	1.000	1.000
497	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), ELK1(2), HRAS(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(2), PPP3CC(1), SHC1(1), SOS1(2), SYK(2), SYT1(2), VAV1(4)	8466405	39	9	39	14	10	11	3	7	6	2	0.486	1.000	1.000
498	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(2), ACVR2A(4), AMH(1), AMHR2(3), BMP2(1), BMP7(1), BMPR1A(3), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(2), CCL26(1), CCL27(1), CCL3(1), CCL7(1), CCL8(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CD40(1), CRLF2(1), CSF1(2), CSF1R(1), CSF2RA(1), CSF2RB(2), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCL16(1), CXCR4(3), EDA(2), EDA2R(1), EDAR(1), EGF(5), EGFR(2), EPO(2), EPOR(2), FASLG(1), FLT1(3), FLT3(3), FLT3LG(1), FLT4(9), GDF5(1), GHR(2), HGF(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(3), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(1), IL12B(1), IL15RA(1), IL17RA(2), IL18RAP(2), IL1B(1), IL1R1(2), IL1R2(1), IL1RAP(2), IL20RA(2), IL21(2), IL21R(1), IL22(1), IL22RA1(1), IL23R(1), IL26(1), IL2RB(2), IL3RA(2), IL4R(3), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), IL9R(2), INHBA(2), INHBB(2), INHBC(1), KDR(1), KIT(4), LEPR(7), LIF(1), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(3), PDGFRB(3), PLEKHO2(1), PRL(6), PRLR(3), RELT(1), TGFB1(1), TGFBR1(8), TGFBR2(10), TNFRSF10A(2), TNFRSF10B(2), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(2), TNFRSF8(1), TNFRSF9(1), TNFSF12(1), TNFSF13(3), TNFSF14(1), TNFSF18(1), TNFSF8(3), TPO(7), TSLP(1), XCR1(3)	39512702	254	70	253	62	72	54	44	41	42	1	0.000374	1.000	1.000
499	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT1(2), AGPAT3(2), AGPAT4(3), CDIPT(3), CHAT(4), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKI(4), DGKQ(3), DGKZ(3), ESCO1(3), ETNK2(2), GPAM(4), GPD1(1), GPD2(1), PCYT1A(2), PCYT1B(1), PHOSPHO1(1), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLD2(4), PPAP2B(2), PPAP2C(1), PTDSS1(2), PTDSS2(1), SH3GLB1(1)	14718836	68	23	67	22	22	10	14	12	10	0	0.239	1.000	1.000
500	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT2(2), AKT3(2), BAD(1), GSK3A(1), GSK3B(2), IL4R(3), IRS1(4), IRS2(4), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SOS1(2), SOS2(1), STAT6(5)	8251540	44	19	44	15	14	12	5	9	4	0	0.337	1.000	1.000
501	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DPYS(3), DTYMK(1), DUT(1), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME7(1), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3A(1), POLR3B(3), POLR3G(1), PRIM1(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(1)	18038719	92	30	89	27	24	18	19	18	13	0	0.197	1.000	1.000
502	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), AGPAT1(2), AGPAT3(2), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CEL(1), DGAT1(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(3), DGKZ(3), GLB1(2), LCT(5), LIPF(2), LIPG(4), LPL(3), PNLIP(2), PPAP2B(2), PPAP2C(1)	10793573	69	22	69	26	32	8	10	8	10	1	0.328	1.000	1.000
503	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADSL(2), ADSS(1), AK2(1), ALLC(2), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J(1), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), FHIT(1), GART(1), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), IMPDH1(2), IMPDH2(3), ITPA(1), NME1(1), NPR1(1), NPR2(2), NT5C(1), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(2), PAPSS2(6), PDE4A(1), PDE4C(2), PDE4D(3), PDE5A(3), PDE6B(3), PDE6C(1), PDE6G(1), PDE7B(1), PDE8A(2), PDE9A(1), PFAS(7), PKLR(2), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(4), POLL(2), POLQ(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLRMT(2), PPAT(2), PRPS1(1), PRPS1L1(3), RRM1(1)	28644458	174	53	172	39	65	36	27	17	27	2	0.000825	1.000	1.000
504	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT2(2), AKT3(2), CASP8(2), CCL3(1), CD14(1), CD40(1), CD80(2), CD86(6), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(3), IKBKB(4), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(2), IRF5(1), IRF7(2), LBP(1), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K7(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), RELA(2), STAT1(3), TBK1(1), TICAM1(2), TLR1(4), TLR2(3), TLR3(2), TLR4(1), TLR5(2), TLR6(4), TLR8(2), TLR9(8), TRAF6(1)	19946465	118	41	116	30	32	17	22	20	26	1	0.0571	1.000	1.000
505	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(9), ASH2L(2), CARM1(2), CTCFL(1), DOT1L(1), EED(3), EHMT1(3), EHMT2(3), EZH1(2), EZH2(3), FBXO11(2), HCFC1(2), HSF4(1), KDM6A(6), MEN1(4), NSD1(6), OGT(4), PAXIP1(1), PPP1CA(1), PRDM2(6), PRDM9(4), PRMT1(1), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(2), RBBP5(1), SATB1(4), SETD1A(3), SETD2(5), SETD8(1), SETDB1(3), SETMAR(2), SMYD3(1), STK38(1), SUV39H2(3), SUV420H1(4), SUV420H2(2), SUZ12(4), WHSC1(1), WHSC1L1(2)	26751545	112	40	108	27	22	18	19	20	30	3	0.249	1.000	1.000
506	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(5), ACTN1(1), AKT1(1), AKT2(2), AKT3(2), ANGPTL2(1), ARHGEF6(2), ARHGEF7(2), BCAR1(2), BRAF(3), CDC42(1), CDKN2A(31), CRK(1), CSE1L(3), DOCK1(4), EPHB2(4), GRB7(2), ILK(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGB3BP(1), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PIK3CA(4), PIK3CB(1), PKLR(2), PLCG1(1), PLCG2(7), PTK2(10), ROCK1(5), ROCK2(2), SHC1(1), SOS1(2), SOS2(1), SRC(2), TERF2IP(1), TLN1(12), TLN2(5), ZYX(1)	27443444	190	67	174	47	44	36	28	30	50	2	0.0206	1.000	1.000
507	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(6), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J(1), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(4), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7B2(2), COX7C(1), COX8C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA13(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), NDUFV2(3), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1)	12417234	75	26	74	25	19	19	12	13	11	1	0.358	1.000	1.000
508	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	164	ADORA2A(1), ADORA3(6), ADRA1A(3), ADRA1D(1), ADRA2A(1), ADRA2C(2), ADRB2(1), AVPR1A(1), AVPR1B(1), AVPR2(2), BDKRB2(1), C3AR1(3), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CCRL2(2), CHML(4), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CMKLR1(1), CX3CR1(1), CXCR4(3), DRD1(5), DRD5(2), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHR(3), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR35(1), GPR4(2), GPR50(1), GPR6(12), GPR83(1), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(2), HRH2(1), HTR1A(3), HTR1D(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(2), HTR5A(4), HTR7(1), LHCGR(2), LTB4R(3), MC3R(4), MC5R(3), MLNR(1), MTNR1A(2), MTNR1B(2), NMUR1(1), NMUR2(3), NPY1R(3), NPY2R(2), NPY5R(1), OPN1SW(1), OPN3(2), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(1), OR10A5(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR8B8(1), OXTR(2), P2RY1(6), P2RY12(1), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(2), RGR(1), RRH(1), SSTR1(2), SSTR4(3), SUCNR1(1), TBXA2R(2), TRHR(2)	27201630	204	63	191	59	66	30	53	28	26	1	0.0103	1.000	1.000
509	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(2), EHMT1(3), EHMT2(3), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(6), OGDH(5), OGDHL(1), PLOD1(3), PLOD2(1), RDH11(2), SETD1A(3), SETDB1(3), SHMT1(1), SHMT2(2), SPCS1(1), SUV39H2(3), TMLHE(1)	12896478	63	22	63	22	20	9	13	8	12	1	0.488	1.000	1.000
510	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(3), CD14(1), CD19(1), CD1A(2), CD1B(4), CD1C(1), CD1D(3), CD1E(1), CD2(3), CD22(2), CD33(3), CD34(1), CD38(2), CD3E(1), CD4(2), CD44(4), CD5(1), CD55(1), CD59(1), CD8B(2), CR1(4), CR2(5), CSF1(2), CSF1R(1), CSF2RA(1), CSF3R(3), DNTT(4), EPO(2), EPOR(2), FCGR1A(1), FLT3(3), FLT3LG(1), GP5(2), GP9(2), HLA-DRB5(1), IL1B(1), IL1R1(2), IL1R2(1), IL3RA(2), IL4R(3), IL6(1), IL6R(1), IL7(1), IL7R(1), IL9R(2), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGAM(4), ITGB3(1), KIT(4), MME(2), MS4A1(4), THPO(1), TPO(7)	18078651	127	43	125	37	29	22	25	26	25	0	0.150	1.000	1.000
511	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(3), ABCA12(14), ABCA13(12), ABCA2(5), ABCA3(6), ABCA4(6), ABCA5(4), ABCA6(5), ABCA7(7), ABCA8(6), ABCA9(9), ABCB1(5), ABCB10(2), ABCB11(2), ABCB4(1), ABCB5(6), ABCB6(4), ABCB8(1), ABCC1(1), ABCC10(4), ABCC11(3), ABCC12(6), ABCC2(3), ABCC3(2), ABCC4(4), ABCC5(2), ABCC6(5), ABCC8(1), ABCC9(3), ABCD1(1), ABCD2(2), ABCD3(1), ABCG1(3), ABCG2(1), ABCG4(4), ABCG5(3), ABCG8(2), CFTR(7), TAP1(4), TAP2(1)	26349773	167	52	161	45	46	35	24	34	25	3	0.0143	1.000	1.000
512	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT2(2), AKT3(2), BAD(1), CDC42(1), CDKN2A(31), CREB1(2), CREB5(1), ERBB4(6), F2RL2(2), GAB1(1), GSK3A(1), GSK3B(2), IFI27(1), INPPL1(2), IRS1(4), IRS2(4), IRS4(16), MET(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PARD3(4), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PREX1(8), PTK2(10), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(2), SOS2(1), TSC1(2), TSC2(6), YWHAE(2), YWHAG(1), YWHAH(1)	17241172	141	71	115	39	22	20	19	20	59	1	0.413	1.000	1.000
513	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(5), ABLIM1(5), ABLIM2(1), ABLIM3(2), ARHGEF12(5), CDC42(1), CXCR4(3), DCC(5), DPYSL2(1), DPYSL5(3), EFNA1(1), EFNB2(1), EPHA1(4), EPHA2(5), EPHA3(1), EPHA4(3), EPHA5(6), EPHA6(3), EPHA7(3), EPHA8(7), EPHB1(2), EPHB2(4), EPHB3(3), EPHB4(5), EPHB6(2), GNAI1(1), GNAI2(1), GSK3B(2), HRAS(1), KRAS(127), L1CAM(5), LIMK2(2), LRRC4C(4), MET(4), NCK1(4), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NRP1(2), NTN4(1), NTNG1(3), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PLXNA1(5), PLXNA2(9), PLXNA3(7), PLXNB1(4), PLXNB2(5), PLXNB3(6), PLXNC1(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PTK2(10), RAC2(1), RASA1(2), RGS3(1), RHOA(1), RHOD(1), RND1(2), ROBO1(7), ROBO2(4), ROBO3(4), ROCK1(5), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(5), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4B(1), SEMA4C(4), SEMA4F(2), SEMA4G(3), SEMA5A(5), SEMA5B(4), SEMA6A(2), SEMA6C(2), SEMA6D(1), SEMA7A(1), SLIT1(6), SLIT2(7), SLIT3(4), SRGAP1(5), SRGAP2(1), SRGAP3(4), UNC5A(2), UNC5B(1), UNC5C(4), UNC5D(4)	44321722	424	136	297	111	100	115	111	54	42	2	3.26e-05	1.000	1.000
514	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(1), ACTN2(4), APC(7), APC2(2), ARAF(2), ARHGEF1(2), ARHGEF12(5), ARHGEF6(2), ARHGEF7(2), ARPC1A(1), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(3), BCAR1(2), BDKRB2(1), BRAF(3), CD14(1), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CRK(1), CRKL(1), CSK(1), CYFIP2(2), DIAPH1(7), DIAPH2(1), DIAPH3(2), DOCK1(4), EGF(5), EGFR(2), FGD1(1), FGF10(1), FGF12(1), FGF13(2), FGF14(2), FGF18(1), FGF2(1), FGF23(1), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(3), FN1(8), GIT1(3), GSN(4), HRAS(1), IQGAP1(2), IQGAP2(1), IQGAP3(3), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(4), ITGAV(3), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), KRAS(127), LIMK2(2), MOS(3), MYH10(4), MYH14(4), MYH9(4), MYL9(1), MYLK(13), MYLK2(4), MYLPF(1), NCKAP1(5), NCKAP1L(5), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PDGFRA(3), PDGFRB(3), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2A(2), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(10), PXN(1), RAC2(1), RDX(4), RHOA(1), ROCK1(5), ROCK2(2), RRAS(2), SCIN(1), SOS1(2), SOS2(1), SSH1(4), TIAM1(8), TIAM2(5), VAV1(4), VCL(1), WASF1(1), WASF2(1), WASL(2)	62145660	446	132	317	116	103	117	125	50	49	2	4.77e-05	1.000	1.000
515	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTN1(1), ACTN2(4), AKT1(1), AKT2(2), AKT3(2), ARHGAP5(5), BAD(1), BCAR1(2), BIRC2(2), BRAF(3), CCND2(3), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(2), COL1A1(3), COL1A2(7), COL2A1(3), COL3A1(6), COL4A1(4), COL4A2(6), COL4A4(4), COL4A6(4), COL5A1(15), COL5A2(7), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(9), COL6A6(6), COMP(2), CRK(1), CRKL(1), CTNNB1(7), DIAPH1(7), DOCK1(4), EGF(5), EGFR(2), ELK1(2), ERBB2(6), FARP2(3), FLNA(10), FLNB(4), FLNC(10), FLT1(3), FN1(8), GSK3B(2), HGF(1), HRAS(1), IBSP(3), IGF1R(6), ILK(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAV(3), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), KDR(1), LAMA1(10), LAMA2(9), LAMA3(5), LAMA4(6), LAMA5(7), LAMB1(4), LAMB2(6), LAMB3(3), LAMB4(4), LAMC1(3), LAMC2(2), LAMC3(2), MAPK8(2), MAPK9(1), MET(4), MYL9(1), MYLK(13), MYLK2(4), MYLPF(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PARVA(1), PARVB(2), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(3), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTK2(10), PXN(1), RAC2(1), RAP1B(3), RELN(13), RHOA(1), ROCK1(5), ROCK2(2), SHC1(1), SHC2(2), SHC4(1), SOS1(2), SOS2(1), SRC(2), THBS1(3), THBS2(4), THBS3(1), THBS4(2), TLN1(12), TLN2(5), TNC(13), TNN(4), TNR(10), TNXB(9), VAV1(4), VCL(1), VTN(2), VWF(5), ZYX(1)	82855584	507	108	500	153	149	105	94	78	75	6	0.00619	1.000	1.000
516	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY7(2), ADCY8(4), ADCY9(4), ADORA2A(1), ADRA1A(3), ADRA1D(1), ADRB2(1), ATP2A1(5), ATP2A2(2), ATP2B1(7), ATP2B2(4), ATP2B3(1), ATP2B4(2), AVPR1A(1), AVPR1B(1), BDKRB2(1), CACNA1A(8), CACNA1B(13), CACNA1C(8), CACNA1D(10), CACNA1E(9), CACNA1F(4), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(5), CALML3(1), CAMK2D(1), CAMK4(1), CCKAR(4), CCKBR(3), CD38(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CHRNA7(1), CYSLTR2(1), DRD1(5), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(5), ERBB4(6), GNA11(2), GNA14(1), GNA15(3), GNAL(2), GNAQ(1), GNAS(12), GRIN1(1), GRIN2A(6), GRIN2C(4), GRIN2D(5), GRM1(9), GRM5(7), GRPR(1), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(2), HTR5A(4), HTR7(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), LHCGR(2), LTB4R2(1), MYLK(13), MYLK2(4), NOS1(7), NOS3(8), OXTR(2), P2RX2(1), P2RX7(1), PDE1B(1), PDE1C(1), PDGFRA(3), PDGFRB(3), PHKA2(5), PHKB(3), PHKG1(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKCG(2), PTGER3(1), PTGFR(2), RYR1(23), RYR2(15), RYR3(22), SLC25A4(1), SLC25A6(2), SLC8A1(2), SLC8A2(3), SLC8A3(5), SPHK1(1), TACR1(3), TACR2(1), TACR3(2), TBXA2R(2), TNNC1(2), TNNC2(1), TRHR(2), TRPC1(2), VDAC1(2), VDAC2(1)	61166999	468	101	456	136	184	68	98	66	46	6	0.000115	1.000	1.000
517	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTB(1), CHAD(1), COL11A1(7), COL11A2(2), COL17A1(3), COL1A1(3), COL1A2(7), COL2A1(3), COL3A1(6), COL4A1(4), COL4A2(6), COL4A4(4), COL4A6(4), COL5A1(15), COL5A2(7), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(9), COL6A6(6), COMP(2), DES(1), DSC1(4), DSC2(4), DSC3(4), DSG1(2), DSG2(3), DSG3(1), DSG4(4), FN1(8), GJA1(1), GJA3(1), GJA4(2), GJA5(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJC3(2), GJD4(2), IBSP(3), INA(2), ITGA6(4), ITGB4(7), KRT1(2), KRT12(2), KRT13(2), KRT14(1), KRT15(2), KRT16(1), KRT19(1), KRT2(7), KRT20(2), KRT24(3), KRT27(1), KRT28(2), KRT3(2), KRT31(2), KRT33A(2), KRT33B(1), KRT34(3), KRT37(1), KRT38(2), KRT39(1), KRT4(2), KRT40(1), KRT5(1), KRT6A(3), KRT6B(1), KRT7(2), KRT72(1), KRT73(1), KRT74(3), KRT75(1), KRT76(5), KRT77(1), KRT78(2), KRT79(2), KRT82(2), KRT83(3), KRT85(1), KRT86(2), LAMA1(10), LAMA2(9), LAMA3(5), LAMA4(6), LAMA5(7), LAMB1(4), LAMB2(6), LAMB3(3), LAMB4(4), LAMC1(3), LAMC2(2), LAMC3(2), LMNB2(1), NES(4), PRPH(1), RELN(13), THBS1(3), THBS2(4), THBS3(1), THBS4(2), TNC(13), TNN(4), TNR(10), TNXB(9), VTN(2), VWF(5)	55629037	376	95	370	123	124	70	75	54	50	3	0.0465	1.000	1.000
518	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	238	ADORA2A(1), ADORA3(6), ADRA1A(3), ADRA2A(1), ADRA2B(4), ADRA2C(2), ADRB2(1), AVPR1A(1), AVPR1B(1), AVPR2(2), BDKRB2(1), C3AR1(3), C5AR1(1), CALCR(1), CCKAR(4), CCKBR(3), CGA(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CRHR1(1), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(5), DRD5(2), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHB(1), FSHR(3), GABBR1(2), GABBR2(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GABRB1(3), GABRB2(1), GABRB3(4), GABRD(2), GABRE(1), GABRG1(1), GABRG2(2), GABRG3(2), GABRP(1), GABRQ(2), GABRR2(1), GALR1(2), GALR2(1), GHR(2), GHRHR(1), GIPR(1), GLP2R(3), GLRA1(3), GLRA2(3), GLRB(1), GNRHR(1), GPR156(2), GPR35(1), GPR50(1), GPR83(1), GRIA1(1), GRIA3(2), GRIA4(3), GRID1(7), GRID2(8), GRIK1(1), GRIK2(9), GRIK3(3), GRIK4(2), GRIK5(2), GRIN1(1), GRIN2A(6), GRIN2B(7), GRIN2C(4), GRIN2D(5), GRIN3A(3), GRIN3B(3), GRM1(9), GRM2(4), GRM3(2), GRM4(3), GRM5(7), GRM6(3), GRM7(4), GRM8(4), GRPR(1), HCRTR1(2), HCRTR2(2), HRH2(1), HTR1A(3), HTR1D(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(2), HTR5A(4), HTR7(1), LEPR(7), LHCGR(2), LTB4R(3), LTB4R2(1), MC2R(2), MC3R(4), MC5R(3), MCHR1(2), MCHR2(1), MLNR(1), MTNR1A(2), MTNR1B(2), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR1(1), NPFFR2(1), NPY1R(3), NPY2R(2), NPY5R(1), NR3C1(2), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(1), OXTR(2), P2RX2(1), P2RX7(1), P2RY1(6), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(4), PRL(6), PRLR(3), PRSS1(3), PRSS3(3), PTGDR(2), PTGER3(1), PTGFR(2), RXFP1(1), SSTR1(2), SSTR4(3), SSTR5(5), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(1), TAAR8(3), TACR1(3), TACR2(1), TACR3(2), TBXA2R(2), THRA(1), THRB(1), TRHR(2), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1)	49630855	397	89	388	124	145	69	81	58	41	3	0.000726	1.000	1.000
519	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD44(4), CHAD(1), COL11A1(7), COL11A2(2), COL1A1(3), COL1A2(7), COL2A1(3), COL3A1(6), COL4A1(4), COL4A2(6), COL4A4(4), COL4A6(4), COL5A1(15), COL5A2(7), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(9), COL6A6(6), DAG1(1), FN1(8), FNDC1(19), FNDC3A(3), FNDC5(1), GP5(2), GP6(2), GP9(2), HMMR(3), HSPG2(3), IBSP(3), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAV(3), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), LAMA1(10), LAMA2(9), LAMA3(5), LAMA4(6), LAMA5(7), LAMB1(4), LAMB2(6), LAMB3(3), LAMB4(4), LAMC1(3), LAMC2(2), LAMC3(2), RELN(13), SDC3(1), SDC4(2), SV2A(2), SV2C(1), THBS1(3), THBS2(4), THBS3(1), THBS4(2), TNC(13), TNN(4), TNR(10), TNXB(9), VTN(2), VWF(5)	50244089	327	86	313	99	87	66	69	47	55	3	0.0571	1.000	1.000
520	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), ADRA1A(3), ADRA1D(1), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(2), ATP1A4(3), ATP1B1(1), ATP1B3(1), ATP2A2(2), ATP2B1(7), ATP2B2(4), ATP2B3(1), CACNA1A(8), CACNA1B(13), CACNA1C(8), CACNA1D(10), CACNA1E(9), CACNA1S(5), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(1), CASQ1(1), CASQ2(8), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), GJA1(1), GJA4(2), GJA5(1), GJB1(1), GJB4(1), GJB6(2), GNA11(2), GNAI2(1), GNAO1(3), GNAQ(1), GNAZ(1), GNB1(3), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GRK4(2), GRK5(1), GRK6(1), ITPR1(10), ITPR2(4), ITPR3(8), KCNB1(5), KCNJ5(1), MIB1(4), NME7(1), PLCB3(4), PRKACB(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(1), RYR1(23), RYR2(15), RYR3(22), SLC8A1(2), SLC8A3(5), USP5(2), YWHAH(1)	42257470	296	81	288	96	112	52	56	34	37	5	0.0171	1.000	1.000
521	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(3), ACTA2(2), ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), ADM(2), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATF5(1), ATP2A2(2), CALCA(1), CAMK2D(1), CNN2(1), CORIN(2), CRHR1(1), DGKZ(3), ETS2(2), GABPA(2), GABPB2(1), GBA2(4), GJA1(1), GNAQ(1), GNB1(3), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GRK4(2), GRK5(1), GRK6(1), GUCY1A3(2), IGFBP4(1), IL1B(1), IL6(1), ITPR1(10), ITPR2(4), ITPR3(8), MAFF(2), MIB1(4), MYLK2(4), NOS1(7), NOS3(8), OXTR(2), PDE4D(3), PLCB3(4), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCH(1), PRKCQ(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS20(1), RGS3(1), RGS7(2), RGS9(1), RYR1(23), RYR2(15), RYR3(22), SLC8A1(2), SP1(1), TNXB(9), USP5(2), YWHAH(1)	38938213	246	67	246	86	97	42	47	31	26	3	0.0883	1.000	1.000
522	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), ADSL(2), ADSS(1), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), ATIC(2), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GART(1), GMPR(2), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), IMPDH1(2), IMPDH2(3), ITPA(1), NME1(1), NME4(1), NME7(1), NPR1(1), NPR2(2), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(1), NT5M(1), NUDT2(1), NUDT9(1), PAICS(2), PAPSS1(2), PAPSS2(6), PDE10A(8), PDE11A(1), PDE1C(1), PDE2A(1), PDE3B(2), PDE4A(1), PDE4C(2), PDE4D(3), PDE5A(3), PDE6G(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(1), PFAS(7), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3A(1), POLR3B(3), POLR3G(1), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(3), RRM1(1), RRM2B(1), XDH(5)	36422480	212	63	207	56	75	37	32	35	31	2	0.0132	1.000	1.000
523	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(4), CADM3(2), CD2(3), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(1), CD6(1), CD80(2), CD86(6), CD8B(2), CDH1(1), CDH15(4), CDH2(5), CDH4(5), CDH5(2), CLDN17(3), CLDN22(1), CLDN3(2), CLDN9(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(7), CTLA4(1), ESAM(1), F11R(1), GLG1(2), HLA-A(2), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), ICAM1(2), ICAM3(1), ICOSLG(1), ITGA4(1), ITGA6(4), ITGA8(2), ITGAL(2), ITGAM(4), ITGAV(3), ITGB2(1), ITGB8(4), JAM2(2), L1CAM(5), NCAM1(2), NCAM2(6), NEGR1(3), NEO1(2), NFASC(4), NLGN1(6), NLGN2(2), NLGN3(4), NRCAM(1), NRXN1(3), NRXN2(6), NRXN3(5), PDCD1(1), PTPRC(2), PTPRF(4), PTPRM(7), PVRL1(2), PVRL2(1), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELL(1), SELP(2), SELPLG(1), SIGLEC1(12), VCAN(10)	32926568	210	60	205	78	70	35	38	29	36	2	0.261	1.000	1.000
524	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT2(2), AKT3(2), CBL(3), CBLB(2), CCND2(3), CCND3(1), CISH(1), CREBBP(3), CRLF2(1), CSF2RA(1), CSF2RB(2), CSF3R(3), EP300(6), EPO(2), EPOR(2), GHR(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(3), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(1), IL12B(1), IL13RA2(1), IL15RA(1), IL20RA(2), IL21(2), IL21R(1), IL22(1), IL22RA1(1), IL23R(1), IL26(1), IL2RB(2), IL3RA(2), IL4R(3), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), IL9R(2), IRF9(1), JAK1(1), JAK2(6), JAK3(3), LEPR(7), LIF(1), LIFR(5), OSMR(3), PIAS1(1), PIAS2(3), PIAS3(1), PIAS4(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRL(6), PRLR(3), PTPN6(4), SOCS4(2), SOCS5(5), SOS1(2), SOS2(1), SPRED1(1), SPRED2(1), STAM(2), STAM2(1), STAT1(3), STAT2(1), STAT3(2), STAT4(1), STAT5A(1), STAT6(5), TPO(7), TSLP(1), TYK2(2)	32198529	183	56	182	61	55	31	33	35	28	1	0.289	1.000	1.000
525	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(3), ASCC3(5), ATP13A2(1), DDX18(1), DDX23(1), DDX4(8), DDX41(2), DDX47(5), DDX50(3), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(4), ENPP3(3), EP400(2), ERCC2(2), ERCC3(3), G6PC2(1), GAA(2), GANC(1), GBA(3), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(4), HK2(6), HK3(4), IFIH1(5), MGAM(3), MOV10L1(5), NUDT8(1), PGM1(1), PGM3(1), PYGL(2), PYGM(1), RAD54B(2), RAD54L(5), RUVBL2(3), SETX(3), SI(5), SKIV2L2(2), SMARCA2(3), SMARCA5(1), TREH(1), UGDH(2), UGP2(3), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), UXS1(2)	27435584	160	55	156	54	43	32	26	24	33	2	0.541	1.000	1.000
526	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(2), ACTN2(4), DES(1), DMD(9), MYBPC1(3), MYBPC2(1), MYBPC3(3), MYH3(2), MYH6(6), MYH7(8), MYH8(4), MYL1(1), MYL3(3), MYL9(1), MYOM1(4), NEB(19), TMOD1(1), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(4), TNNT2(2), TNNT3(1), TPM1(1), TPM2(2), TPM3(1), TTN(106)	30526748	195	55	195	60	51	44	46	28	22	4	0.292	1.000	1.000
527	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(3), CHUK(1), CREB1(2), DAXX(3), ELK1(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(2), MAP3K12(4), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP3K9(6), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK4(1), MAPK6(3), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2C(3), MEF2D(2), MKNK2(1), NFKBIA(1), PAK2(2), RELA(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(2), RPS6KA5(2), RPS6KB2(1), SHC1(1), SP1(1), STAT1(3), TGFB1(1), TGFBR1(8), TRADD(1), TRAF2(2)	21614029	121	48	120	37	30	29	23	12	27	0	0.234	1.000	1.000
528	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK2(1), CLK3(2), CLK4(2), COL2A1(3), CPSF1(3), CPSF2(4), CPSF4(1), CSTF1(1), CSTF2(1), CSTF2T(3), CSTF3(3), DDX20(1), DHX15(4), DHX16(4), DHX38(2), DHX8(3), DHX9(2), DICER1(9), LSM2(2), METTL3(2), NCBP2(2), NONO(1), NUDT21(1), NXF1(2), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(5), PPM1G(2), PRPF3(2), PRPF4(2), PRPF8(5), PTBP1(3), PTBP2(2), RBM17(1), SF3A2(1), SF3B1(4), SF3B2(3), SF3B5(1), SNRPA(1), SNRPB2(1), SNRPE(2), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(2), U2AF1(2), U2AF2(1), XRN2(4)	23426986	116	46	112	33	37	18	16	20	22	3	0.328	1.000	1.000
529	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(4), ARHGAP5(5), BCAR1(2), CDC42(1), CDH5(2), CLDN17(3), CLDN22(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(5), CTNNA3(5), CTNNB1(7), CTNND1(2), CXCR4(3), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(2), ITGA4(1), ITGAL(2), ITGAM(4), ITGB2(1), ITK(1), JAM2(2), MAPK11(1), MAPK12(1), MAPK13(1), MLLT4(4), MMP2(2), MMP9(3), MYL9(1), MYLPF(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(10), PXN(1), RAC2(1), RAP1B(3), RAPGEF3(3), RAPGEF4(3), RASSF5(1), RHOA(1), RHOH(2), ROCK1(5), ROCK2(2), SIPA1(3), THY1(1), TXK(1), VAV1(4), VCL(1)	27837328	154	45	150	59	47	29	20	25	31	2	0.634	1.000	1.000
530	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(8), ACSL1(1), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADIPOR1(2), AKT1(1), AKT2(2), AKT3(2), CAMKK1(1), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(4), IRS1(4), IRS2(4), IRS4(16), JAK1(1), JAK2(6), JAK3(3), LEPR(7), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(2), PCK1(3), PCK2(2), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(4), PRKCQ(2), RELA(2), RXRA(1), RXRB(2), RXRG(1), SLC2A1(3), STAT3(2), STK11(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(2), TYK2(2)	18610036	136	45	124	43	34	29	18	16	38	1	0.265	1.000	1.000
531	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(1), ALG10(1), ALG10B(1), ALG11(2), ALG12(3), ALG13(1), ALG8(1), ALG9(1), B3GNT2(2), B3GNT6(2), B3GNT7(1), B4GALT2(1), B4GALT5(2), C1GALT1(1), CHPF(2), CHST1(1), CHST11(2), CHST12(1), CHST14(2), CHST2(2), CHST4(1), CHST6(2), DDOST(1), DPAGT1(2), EXT1(2), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GALNT1(3), GALNT10(5), GALNT13(2), GALNT2(3), GALNT5(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GANAB(3), HS2ST1(1), HS3ST2(3), HS6ST1(2), HS6ST2(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(5), MGAT1(1), MGAT2(1), MGAT3(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(3), NDST3(3), NDST4(2), OGT(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), WBSCR17(2), XYLT1(5), XYLT2(2)	24823060	135	44	133	42	45	23	33	15	19	0	0.151	1.000	1.000
532	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(2), ACVRL1(1), AKT1(1), BMPR1A(3), BMPR2(3), BUB1(3), CDIPT(3), CDKL1(1), CLK1(3), CLK2(1), CLK4(2), COL4A3BP(1), CSNK2A1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(3), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(2), ITPKB(3), MAP3K10(2), MOS(3), OCRL(1), PAK4(1), PIK3C2A(5), PIK3C2B(10), PIK3CA(4), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), PRKG1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(2), STK11(3), TGFBR1(8), VRK1(1)	25403431	138	44	138	40	49	21	22	25	21	0	0.0996	1.000	1.000
533	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(2), CAPN1(1), CAPN11(2), CAPN3(4), CAPN5(3), CAPN6(2), CAPN9(1), CAPNS1(2), CDC42(1), CRK(1), CSK(1), DOCK1(4), GIT2(2), ILK(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(4), ITGAV(3), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), MAP2K3(1), MAP2K6(3), MAPK12(1), MAPK4(1), MAPK6(3), MAPK7(4), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PIK3R2(2), PTK2(10), PXN(1), RAC2(1), RAP1B(3), ROCK1(5), ROCK2(2), SDCCAG8(2), SEPP1(2), SHC1(1), SORBS1(2), SOS1(2), SRC(2), TLN1(12), TNS1(4), VCL(1), ZYX(1)	30081152	157	43	153	47	41	33	32	17	33	1	0.110	1.000	1.000
534	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALML3(1), CDIPT(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKI(4), DGKQ(3), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(1), INPP5E(1), INPPL1(2), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), OCRL(1), PI4KA(4), PI4KB(1), PIK3C2A(5), PIK3C2B(10), PIK3C3(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2A(2), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(1), PLCG2(7), PRKCG(2), SYNJ1(1), SYNJ2(3)	27988646	138	42	138	40	51	19	24	23	21	0	0.0494	1.000	1.000
535	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BTRC(2), CSNK1A1L(4), CSNK1D(1), CSNK1E(1), CSNK1G3(2), DHH(2), FBXW11(1), GLI1(4), GLI2(4), GLI3(10), GSK3B(2), HHIP(4), LRP2(7), PRKACB(1), PRKACG(3), PTCH1(5), PTCH2(6), SMO(1), STK36(1), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT3A(4), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), ZIC2(2)	13726910	96	40	95	33	39	21	17	11	8	0	0.159	1.000	1.000
536	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(10), B3GALT4(2), CDR1(1), DGKI(4), FAU(1), IL6ST(3), RPL11(1), RPL12(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL19(1), RPL22(5), RPL28(2), RPL32(1), RPL34(1), RPL35(1), RPL36(1), RPL3L(2), RPL4(3), RPL6(1), RPL7A(2), RPLP2(1), RPS11(2), RPS12(1), RPS25(1), RPS27(1), RPS27A(1), RPS28(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA6(4), RPS6KB2(1), RPSA(1), TSPAN9(1), UBB(1)	11673835	70	35	66	28	14	10	17	8	20	1	0.885	1.000	1.000
537	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(6), CCKBR(3), CCR2(1), CELSR1(4), CELSR2(9), CELSR3(10), CHRM2(3), CHRM3(1), CIDEB(1), EMR2(1), EMR3(1), FSHR(3), GHRHR(1), GNRHR(1), GPR116(3), GPR133(7), GPR135(1), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GPR84(1), GRM1(9), GRPR(1), LGR6(3), LPHN2(8), LPHN3(1), LTB4R2(1), OR2M4(2), P2RY13(3), PTGFR(2), SMO(1), TAAR5(2), TSHR(3), VN1R1(1)	14910030	98	34	98	33	39	20	19	13	7	0	0.0732	1.000	1.000
538	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(5), ATP13A2(1), DDX18(1), DDX23(1), DDX4(8), DDX41(2), DDX47(5), DDX50(3), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHFR(1), DHX58(4), EP400(2), ERCC2(2), ERCC3(3), FPGS(3), GCH1(1), GGH(2), IFIH1(5), MOV10L1(5), NUDT8(1), QDPR(3), RAD54B(2), RAD54L(5), RUVBL2(3), SETX(3), SKIV2L2(2), SMARCA2(3), SMARCA5(1)	13983542	95	30	93	36	23	22	16	13	19	2	0.688	1.000	1.000
539	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(2), AKT3(2), BRAF(3), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRKAA1(2), PRKAA2(1), RHEB(1), RICTOR(6), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), RPS6KA6(4), RPS6KB2(1), STK11(3), TSC1(2), TSC2(6), ULK1(3), ULK3(1)	11956964	66	29	66	22	18	14	12	7	15	0	0.515	1.000	1.000
540	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), ATF1(1), BRAF(3), CAMP(2), CREB1(2), CREB5(1), CREBBP(3), CRKL(1), DAG1(1), EGR1(4), EGR3(2), ELK1(2), GNAQ(1), MAP1B(6), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RPS6KA3(1), SHC1(1), SRC(2), TERF2IP(1), TH(1)	11664352	64	28	64	25	18	9	14	11	12	0	0.655	1.000	1.000
541	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), BAD(1), CABIN1(3), CAMK4(1), CD3E(1), CREBBP(3), CSNK2A1(1), CTLA4(1), EGR3(2), EP300(6), FCER1A(1), FOSL1(1), GATA3(3), GATA4(1), GSK3A(1), GSK3B(2), HRAS(1), IL1B(1), IL6(1), ITK(1), JUNB(1), KPNA5(2), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(1), MEF2D(2), MYF5(2), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(4), OPRD1(2), P2RX7(1), PPIA(2), PPP3CC(1), PPP3R1(1), PTPRC(2), RELA(2), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(2), TRPV6(6), VAV1(4), XPO5(2)	20277803	103	27	103	32	33	25	14	11	19	1	0.140	1.000	1.000
542	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(2), ISYNA1(1), ITPKB(3), MIOX(1), OCRL(1), PI4KA(4), PI4KB(1), PIK3C3(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIP4K2A(2), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(1), PLCG2(7), SYNJ1(1), SYNJ2(3)	16625380	71	27	71	25	23	10	13	14	11	0	0.371	1.000	1.000
543	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), AGPAT1(2), AGPAT3(2), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), CEL(1), DGAT1(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKI(4), DGKQ(3), DGKZ(3), GK2(4), GLB1(2), GPAM(4), LCT(5), LIPA(1), LIPF(2), LIPG(4), LPL(3), MGLL(4), PNLIP(2), PPAP2B(2), PPAP2C(1)	13111026	87	25	87	30	34	15	15	10	12	1	0.203	1.000	1.000
544	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(1), GTF2E1(2), GTF2F1(1), NCOA2(3), NCOA3(16), NCOR2(3), POLR2A(5), RXRA(1), TBP(1)	5593584	36	24	26	15	7	3	6	2	17	1	0.979	1.000	1.000
545	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), BTG1(1), CBX3(4), CLOCK(4), CRY1(1), CRY2(1), DNAJA1(2), EIF4G2(1), ETV6(1), GFRA1(3), GSTP1(1), HERPUD1(2), HSPA8(2), IDI1(1), MYF6(1), NCKAP1(5), NCOA4(1), NR1D2(1), PER1(3), PER2(5), PPP1R3C(2), PURA(1), TUBB3(2), UCP3(1), UGP2(3)	8164695	51	23	47	22	11	8	6	13	13	0	0.914	1.000	1.000
546	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(4), APH1A(2), CREBBP(3), CTBP2(4), DLL1(2), DLL4(2), DTX1(3), DTX2(4), DVL1(4), DVL2(4), DVL3(1), EP300(6), JAG1(1), JAG2(3), LFNG(1), MAML1(2), MAML2(3), MAML3(1), NCOR2(3), NOTCH1(9), NOTCH2(6), NOTCH3(7), NOTCH4(5), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RBPJL(1), SNW1(1)	15905075	88	23	87	39	29	23	17	10	9	0	0.606	1.000	1.000
547	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT2(1), FBP2(1), GAA(2), GANAB(3), GCK(1), GLB1(2), HK1(4), HK2(6), HK3(4), LCT(5), MGAM(3), PFKM(3), PGM1(1), PGM3(1)	7245344	38	20	38	14	16	3	7	1	10	1	0.585	1.000	1.000
548	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), CHIT1(3), CYB5R1(3), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(1), GNPDA1(2), HEXA(2), HEXB(2), HK1(4), HK2(6), HK3(4), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), PGM3(1), PHPT1(1), RENBP(1), UAP1(1)	6355090	44	20	44	15	16	4	9	3	12	0	0.714	1.000	1.000
549	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CAMK2D(1), GNA11(2), GNAI1(1), GNB1(3), HRAS(1), JAK2(6), MAPK8(2), MAPT(3), MYLK(13), PLCG1(1), SHC1(1), SOS1(2), STAT1(3), STAT3(2), STAT5A(1), SYT1(2)	9255162	45	18	43	16	13	8	5	6	12	1	0.643	1.000	1.000
550	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BAD(1), CBL(3), CFLAR(3), CRKL(1), HRAS(1), IL2RB(2), IRS1(4), JAK1(1), JAK3(3), PIK3CA(4), PIK3R1(1), PPIA(2), PTPN6(4), SHC1(1), SOS1(2), STAT5A(1), SYK(2)	8064364	37	18	37	18	11	7	7	9	3	0	0.857	1.000	1.000
551	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(2), AKT3(2), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(1), EPHB2(4), ITPKB(3), NFAT5(4), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(7), SHC1(1), SOS1(2), SOS2(1), SYK(2), VAV1(4)	11730750	52	18	52	21	18	11	5	10	7	1	0.573	1.000	1.000
552	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BAD(1), BRAF(3), CREB1(2), CREB5(1), DUSP6(2), DUSP9(1), MKNK2(1), MOS(3), RPS6KA1(2), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(2), SOS2(1)	6593087	24	18	24	14	7	4	4	2	7	0	0.976	1.000	1.000
553	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(1), ALAS1(1), ALAS2(3), AOC2(2), AOC3(3), CHDH(1), DAO(2), DMGDH(3), GARS(6), GLDC(1), HSD3B7(3), PHGDH(2), PSAT1(1), RDH11(2), SARDH(2), SARS2(3), SHMT1(1), SHMT2(2), TARS(2)	9549904	43	17	41	19	23	8	4	5	2	1	0.640	1.000	1.000
554	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(2), HEXB(2), LCT(5), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3)	3634243	32	17	32	13	9	4	7	1	10	1	0.616	1.000	1.000
555	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(1), ALAS1(1), ALAS2(3), AOC2(2), AOC3(3), CHDH(1), CPT1B(5), DAO(2), DMGDH(3), GARS(6), GLDC(1), PLCB2(4), PLCG1(1), PLCG2(7), SARDH(2), SHMT1(1), SHMT2(2), TARS(2)	9398882	49	16	49	20	20	11	6	5	6	1	0.567	1.000	1.000
556	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(3), CARS2(2), DARS(1), EARS2(1), EPRS(1), FARS2(1), FARSA(1), FARSB(1), GARS(6), IARS(4), KARS(1), LARS2(1), MARS2(2), NARS2(1), PARS2(1), QARS(2), RARS(1), RARS2(3), SARS2(3), TARS(2), VARS(3), VARS2(2), WARS(2)	11944294	47	16	45	21	14	11	10	6	6	0	0.826	1.000	1.000
557	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(2), ELK1(2), FPR1(2), GNA15(3), GNB1(3), HRAS(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKBIA(1), PLCB1(1), PPP3CA(2), PPP3CC(1), RELA(2), SYT1(2)	8558272	46	15	46	17	12	11	9	5	8	1	0.613	1.000	1.000
558	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(3), CHAT(4), DBH(1), DDC(1), GAD1(5), GAD2(7), PAH(1), SLC18A3(3), TH(1), TPH1(2)	3242722	29	14	29	12	10	2	9	2	5	1	0.617	1.000	1.000
559	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(3), HRAS(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(10), PXN(1), RELA(2)	6226784	31	14	28	13	6	7	4	4	10	0	0.879	1.000	1.000
560	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(1), ALG10B(1), ALG11(2), ALG12(3), ALG13(1), ALG5(1), ALG8(1), ALG9(1), B4GALT2(1), DDOST(1), DHDDS(1), DPAGT1(2), GANAB(3), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(5), MGAT1(1), MGAT2(1), MGAT3(2), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1)	9477580	37	14	37	14	11	10	6	6	4	0	0.568	1.000	1.000
561	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E1(2), GTF2F1(1), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(2), STON1(2), TAF1(5), TAF1L(5), TAF2(1), TAF4(4), TAF4B(2), TAF5L(2), TAF6(1), TAF6L(3)	7951189	34	14	34	13	11	5	8	6	4	0	0.769	1.000	1.000
562	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A2(2), EIF4B(3), EIF4G1(8), EIF4G2(1), EIF4G3(5), FKBP1A(1), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), TSC1(2), TSC2(6)	6119033	38	14	38	12	10	7	11	6	4	0	0.561	1.000	1.000
563	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(3), GTF2E1(2), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3B(3), POLR3E(4), TAF6(1), TBP(1)	7700770	35	14	34	12	14	5	8	2	6	0	0.573	1.000	1.000
564	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(1), CD97(1), CRHR1(1), CRHR2(1), ELTD1(5), EMR1(3), EMR2(1), GHRHR(1), GIPR(1), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(8), LPHN3(1), VIPR1(1), VIPR2(1)	5984683	33	13	33	16	6	8	5	9	5	0	0.791	1.000	1.000
565	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(2), AMD1(1), DNMT3A(7), DNMT3B(5), MARS2(2), MAT2B(2), MTR(4), TAT(1)	4592622	24	13	23	15	6	5	5	2	6	0	0.954	1.000	1.000
566	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), B3GAT3(2), CHPF(2), CHST11(2), CHST12(1), CHST14(2), DSE(4), XYLT1(5), XYLT2(2)	3322385	21	13	21	11	9	3	7	2	0	0	0.638	1.000	1.000
567	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX15(1), ALOX15B(1), ALOX5(1), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2E1(1), CYP2J2(4), CYP2U1(1), CYP4A22(1), CYP4F2(2), DHRS4(1), EPHX2(1), GGT1(1), GPX1(1), GPX5(3), GPX6(1), LTA4H(1), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PTGDS(3), PTGES2(1), PTGIS(2), PTGS1(1), TBXAS1(1)	8674299	43	13	43	22	14	9	13	1	5	1	0.850	1.000	1.000
568	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(2), DNMT3A(7), DNMT3B(5), MARS2(2), MAT2B(2), MTR(4)	3847715	22	13	21	13	6	4	5	2	5	0	0.925	1.000	1.000
569	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), CASP3(2), CASP8(2), CFLAR(3), MAP2K4(5), MAP3K7(2), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(2)	6126545	31	13	31	12	9	4	6	6	6	0	0.698	1.000	1.000
570	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(2), FUCA2(1), GBA(3), GLB1(2), GNS(1), GUSB(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(5), MAN2B1(1), MAN2B2(2), MANBA(1), NAGLU(2), NEU4(1)	7788790	32	12	32	16	10	5	7	3	6	1	0.817	1.000	1.000
571	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(6), ARRB2(2), CALML3(1), CAMK2D(1), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(4), GNAL(2), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(1), PRKACB(1), PRKACG(3), PRKG1(1), PRKG2(1)	6767858	37	12	36	15	13	6	11	5	2	0	0.627	1.000	1.000
572	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX15(1), ALOX5(1), CYP4F2(2), EPX(4), GGT1(1), LPO(5), LTA4H(1), MPO(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PRDX1(1), PTGDS(3), PTGES2(1), PTGIS(2), PTGS1(1), TBXAS1(1), TPO(7)	6201140	41	12	41	19	19	4	10	2	5	1	0.790	1.000	1.000
573	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(1), IL22RA1(1), JAK1(1), JAK2(6), JAK3(3), STAT1(3), STAT3(2), STAT5A(1), TYK2(2)	4124985	22	11	21	10	7	2	4	2	7	0	0.894	1.000	1.000
574	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(3), EP300(6), IL7(1), IL7R(1), JAK1(1), JAK3(3), LCK(1), PIK3CA(4), PIK3R1(1), STAT5A(1)	6232929	22	11	22	10	7	3	5	4	3	0	0.768	1.000	1.000
575	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), DOT1L(1), EHHADH(2), EHMT1(3), EHMT2(3), GCDH(2), HADHA(1), PLOD1(3), PLOD2(1), SHMT1(1), SHMT2(2), TMLHE(1)	8227578	35	11	35	17	13	5	8	1	7	1	0.820	1.000	1.000
576	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5R1(1), MAP3K1(3), MYLK(13), NCF2(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), RALBP1(2), TRIO(6), VAV1(4), WASF1(1)	7721511	40	11	39	15	13	8	6	7	4	2	0.598	1.000	1.000
577	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), BLNK(1), ELK1(2), HRAS(1), MAP3K1(3), MAPK8IP3(4), PAPPA(3), RPS6KA1(2), RPS6KA3(1), SHC1(1), SOS1(2), SYK(2), VAV1(4)	7165978	28	11	28	11	10	4	4	4	5	1	0.684	1.000	1.000
578	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), DARS(1), EPRS(1), FARS2(1), GARS(6), IARS(4), KARS(1), LARS2(1), MARS2(2), QARS(2), RARS(1), TARS(2), WARS(2)	7010918	26	10	26	11	7	6	6	5	2	0	0.755	1.000	1.000
579	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), LCT(5), PGM1(1), PYGL(2), PYGM(1), TPI1(3), TREH(1)	2997589	17	10	17	11	6	3	1	1	5	1	0.897	1.000	1.000
580	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(3), IRS1(4), JAK1(1), JAK3(3), SHC1(1), STAT6(5)	3305550	18	10	18	10	7	5	2	3	1	0	0.804	1.000	1.000
581	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), HRAS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(6), JAK3(3), SHC1(1), SOS1(2), SRF(1), STAT3(2)	5347817	25	10	24	14	5	4	3	3	10	0	0.979	1.000	1.000
582	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(3), EP300(6), LPL(3), NCOA2(3), PPARG(1), RXRA(1)	4068132	17	10	17	10	6	2	3	2	4	0	0.925	1.000	1.000
583	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), CRKL(1), GNAQ(1), HRAS(1), MAP2K3(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PLCG1(1), SHC1(1), SOS1(2), SRC(2), SYT1(2)	6351147	24	10	24	12	6	5	3	5	4	1	0.860	1.000	1.000
584	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(6), JAK3(3), PIAS3(1), PTPRU(6), REG1A(1), SRC(2), STAT3(2)	3408766	25	10	23	13	8	5	5	0	7	0	0.909	1.000	1.000
585	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(2), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2)	5149431	29	9	29	13	9	6	7	3	4	0	0.737	1.000	1.000
586	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GLB1(2), GNS(1), GUSB(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(5), NAGLU(2)	4613318	21	9	21	13	5	5	3	2	5	1	0.930	1.000	1.000
587	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(3), CYP2C9(2), CYP2E1(1), CYP2J2(4), CYP3A5(1), CYP3A7(2), HSD3B7(3), PLA2G1B(1), PLA2G3(1), PLA2G6(4), RDH11(2)	5277633	30	9	30	11	7	4	11	6	2	0	0.683	1.000	1.000
588	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT2(1), B4GALT5(2), DDOST(1), DPAGT1(2), MAN1A1(1), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(2), MGAT4B(1), MGAT5(2), ST6GAL1(1)	4445849	17	9	17	10	7	3	2	4	1	0	0.891	1.000	1.000
589	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(4), IL1R1(2), MAP3K1(3), MAP3K7(2), NFKBIA(1), RELA(2), TLR4(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1)	5481205	23	9	22	11	5	3	7	4	4	0	0.925	1.000	1.000
590	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(1), JAK2(6), JAK3(3), PIAS1(1), PIAS3(1), PTPRU(6), REG1A(1), SOAT1(1)	3084396	21	9	19	12	8	2	5	0	6	0	0.959	1.000	1.000
591	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR3(2), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(3), NFKBIA(1), PLCG1(1), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(2), SYT1(2), VIPR2(1)	6204845	32	9	32	12	10	7	4	5	5	1	0.518	1.000	1.000
592	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST2(3), XYLT1(5), XYLT2(2)	1519291	12	8	12	13	5	4	2	1	0	0	0.965	1.000	1.000
593	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST2(3), XYLT1(5), XYLT2(2)	1519291	12	8	12	13	5	4	2	1	0	0	0.965	1.000	1.000
594	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(3), GPX6(1), GSR(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), OPLAH(3)	5051763	32	8	32	16	8	9	7	4	4	0	0.649	1.000	1.000
595	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(2), GGT1(1), MARS2(2), MAT2B(2), PAPSS1(2), PAPSS2(6), SCLY(2)	2745703	17	8	16	11	4	4	2	1	6	0	0.952	1.000	1.000
596	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX1(1), GPX5(3), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), PGD(1)	4082331	26	7	26	13	6	7	4	5	4	0	0.691	1.000	1.000
597	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IL12B(1), IL4R(3), TGFB1(1)	4437256	19	7	19	10	4	4	4	4	3	0	0.817	1.000	1.000
598	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT3(2), AGPAT4(3), AGPS(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLD2(4), PPAP2B(2), PPAP2C(1)	5143305	28	6	27	11	10	3	6	4	5	0	0.686	1.000	1.000
599	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(1), RELA(2), TNFAIP3(2), TNFRSF1B(1), TRAF2(2)	4986016	19	6	19	10	3	6	6	2	2	0	0.871	1.000	1.000
600	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(4), PTGDS(3), PTGIS(2), PTGS1(1), TBXAS1(1)	3375438	17	5	17	10	8	2	4	1	2	0	0.855	1.000	1.000
601	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP23(2), SNAP29(3), STX11(2), STX12(1), STX3(1), STX4(2), STX7(1), VAMP4(1), VAMP7(1), VTI1A(1)	3725679	15	5	15	13	8	0	2	1	4	0	0.994	1.000	1.000
602	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), HRAS(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(1), SOS1(2), STAT5A(1), SYK(2)	5252525	19	5	19	10	7	5	1	3	3	0	0.819	1.000	1.000
603	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(1)	1162098	7	3	7	5	5	1	0	1	0	0	0.915	1.000	1.000
604	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), NOX1(2), RELA(2), XDH(5)	2207882	11	3	11	7	3	3	3	2	0	0	0.918	1.000	1.000
605	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PNPO(1), PSAT1(1)	1069690	4	3	4	4	1	0	3	0	0	0	0.955	1.000	1.000
606	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), NFKBIA(1), PLCB1(1), RELA(2)	3428502	7	2	7	5	2	2	2	1	0	0	0.953	1.000	1.000
607	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1), IL16(1), IL6(1), IL9(1)	2184111	4	2	4	3	0	2	1	1	0	0	0.838	1.000	1.000
608	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1)	658864	2	2	2	2	0	2	0	0	0	0	0.927	1.000	1.000
609	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(1), TGM2(1)	1096974	2	2	2	2	2	0	0	0	0	0	0.893	1.000	1.000
610	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	NDUFA13(1)	918008	1	1	1	2	0	1	0	0	0	0	0.981	1.000	1.000
611	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1)	1487161	2	1	2	4	1	1	0	0	0	0	0.984	1.000	1.000
612	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	373143	1	1	1	2	0	0	1	0	0	0	0.995	1.000	1.000
613	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(3), FBL(1), GPT(1), LDHB(1)	2003358	9	1	9	6	2	1	5	1	0	0	0.923	1.000	1.000
614	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8		663531	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		110666	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		333709	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
