rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(2), GH1(2), GHR(1), IGF1R(2), PIK3CA(12), PIK3R1(1), SHC1(2), SOD2(1), SOD3(1)	8140334	27	26	25	3	6	6	4	9	2	0	0.0382	0.000609	0.375
2	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(3), CYP2C9(2)	1280663	5	5	5	0	3	1	0	1	0	0	0.247	0.00245	0.755
3	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), GH1(2), GHR(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1), RELA(2), YWHAH(1)	8894992	24	23	22	3	4	8	3	8	1	0	0.0586	0.00863	1.000
4	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(2), HDC(1), PNMT(1), TPH1(1)	3802340	10	10	10	0	5	1	2	2	0	0	0.0299	0.0246	1.000
5	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(2), PTGS1(2), PTGS2(3)	3380190	8	8	8	1	2	3	0	2	1	0	0.204	0.0292	1.000
6	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(1), KLK2(1), NTRK1(4), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), SHC1(2), SOS1(1)	9556750	28	24	26	4	8	9	2	7	2	0	0.0549	0.0335	1.000
7	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(9), CD14(1), FZD1(2), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LEF1(2), LY96(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1), RELA(2), TLR4(1)	18339151	40	38	38	5	9	9	5	8	9	0	0.00843	0.0410	1.000
8	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(4), CDKN2A(1), MDM2(1), MYC(1), PIK3CA(12), PIK3R1(1), POLR1A(3), POLR1B(2), POLR1C(2), RAC1(1), RB1(2)	12322001	30	24	29	3	5	3	5	11	5	1	0.0453	0.0577	1.000
9	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(1), GRB2(1), MAPK1(1), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PTK2(2), SHC1(2), SOS1(1)	11385346	26	23	24	3	8	8	2	7	1	0	0.0319	0.0635	1.000
10	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), EHHADH(5), HADHB(1)	5278494	10	10	10	0	3	1	1	3	2	0	0.0730	0.0670	1.000
11	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(12), PIK3R1(1), PLCB1(3), PLCG1(1), PRKCA(2), VAV1(3)	8109425	25	22	23	4	7	6	2	10	0	0	0.136	0.0752	1.000
12	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), GRB2(1), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), NTRK1(4), PIK3CA(12), PIK3R1(1), PLCG1(1), RPS6KA1(1), SHC1(2)	11648534	30	26	28	4	11	9	3	6	1	0	0.0192	0.0757	1.000
13	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(5)	3044689	6	6	6	0	2	1	0	2	1	0	0.189	0.0823	1.000
14	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(2), SP1(2), SP3(3)	4218255	10	9	10	2	1	2	1	2	3	1	0.378	0.0858	1.000
15	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(2), EPX(2), LPO(1), MPO(1), MTHFR(2), SHMT1(1), SHMT2(1), TPO(3)	7317140	13	13	13	1	6	4	1	1	1	0	0.0454	0.108	1.000
16	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(2), CDK7(1), CDKN1A(2), NEK1(2)	4360755	8	8	8	0	6	0	0	1	1	0	0.140	0.110	1.000
17	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(1), CDKN1A(2), GRB2(1), NTRK1(4), PIK3CA(12), PIK3CD(4), SHC1(2), SOS1(1)	9847597	30	27	28	6	9	9	2	6	4	0	0.0725	0.113	1.000
18	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(5), HADH(1), HSD17B4(3), SIRT1(2), SIRT2(1)	7448940	13	13	13	2	4	4	0	3	2	0	0.202	0.125	1.000
19	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1)	4172578	7	7	7	0	0	2	1	1	3	0	0.109	0.127	1.000
20	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IL12A(1), IL12B(1)	1888234	4	4	4	1	1	0	0	2	1	0	0.623	0.129	1.000
21	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(2), AASDHPPT(1), AASS(1), KARS(1)	4391860	7	7	7	0	0	0	2	4	1	0	0.211	0.136	1.000
22	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1), TSC1(1), TSC2(4)	16914710	31	29	29	3	5	6	2	14	4	0	0.0334	0.139	1.000
23	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(2), NRG2(4), NRG3(3), PRKCA(2)	5690073	11	10	11	1	5	1	1	2	2	0	0.136	0.149	1.000
24	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(2), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	5798250	9	9	9	0	2	2	1	1	3	0	0.0370	0.165	1.000
25	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11B1(1), CYP11B2(2), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	5798250	9	9	9	0	2	2	1	1	3	0	0.0370	0.165	1.000
26	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ7(1)	2511430	4	4	4	1	0	1	2	0	1	0	0.489	0.165	1.000
27	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(3), ERBB3(4), NRG1(5)	6493121	14	13	14	3	2	2	0	8	2	0	0.384	0.173	1.000
28	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(1), HADHB(1), HSD17B4(3), MECR(1), PPT2(1)	5324847	8	8	8	0	3	3	0	1	1	0	0.0510	0.182	1.000
29	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(1), AASS(1), KARS(1)	2972496	5	5	5	0	0	0	2	3	0	0	0.261	0.183	1.000
30	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(2), ADORA2A(1), ADORA3(2), P2RY1(1), P2RY6(1)	3768644	7	7	7	1	4	1	0	2	0	0	0.213	0.183	1.000
31	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), CYR61(1), EIF4E(1), IL1A(1), JUND(1), NR4A3(1), WDR1(1)	6778226	9	9	9	1	2	1	3	2	1	0	0.208	0.188	1.000
32	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(2), KERA(2)	2269845	4	4	4	1	0	0	0	3	1	0	0.827	0.207	1.000
33	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), EHHADH(5), SDHB(1)	4923166	7	7	7	0	2	2	0	2	1	0	0.129	0.223	1.000
34	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1), LARS(2), LARS2(2), PDHA2(3)	6318199	9	9	9	0	2	2	1	3	1	0	0.0662	0.228	1.000
35	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(3), CDKN1A(2), CPB2(1), HIC1(3), MDM2(1), NFKBIB(1), NQO1(1)	8625865	16	13	15	1	7	3	1	2	3	0	0.0376	0.232	1.000
36	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP5(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(3), PON3(1)	11378759	21	18	20	2	5	2	3	6	5	0	0.0293	0.237	1.000
37	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(1), SP1(2), SP3(3)	3932523	6	6	6	1	0	1	0	3	2	0	0.534	0.246	1.000
38	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL16(3), IL1A(1), IL4(1), IL6(1), IL9(1), TNF(1)	6282456	12	11	12	2	4	2	1	3	2	0	0.183	0.251	1.000
39	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(3)	1143265	4	4	4	2	0	1	0	2	1	0	0.807	0.253	1.000
40	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(1), SRP19(1), SRP54(2)	4772172	6	6	5	0	0	2	1	1	2	0	0.180	0.264	1.000
41	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), PIK3CA(12), PIK3R1(1), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(2)	11665958	23	22	21	4	3	7	5	7	1	0	0.109	0.272	1.000
42	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(1), IRS1(2), MAPK1(1), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PRKCA(2)	17264495	31	28	29	4	5	6	2	14	4	0	0.0856	0.277	1.000
43	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), MUSK(3), PIK3CA(12), PIK3R1(1), PTK2(2), YWHAH(1)	10244879	22	19	20	3	5	8	2	7	0	0	0.0431	0.279	1.000
44	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	322142	1	1	1	0	0	0	0	0	1	0	0.607	0.292	1.000
45	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(3)	2463353	4	4	3	0	2	0	0	2	0	0	0.304	0.294	1.000
46	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(2), EPX(2), LPO(1), MPO(1), SHMT1(1), SHMT2(1), TPO(3)	7431587	11	11	11	1	5	3	1	1	1	0	0.0884	0.294	1.000
47	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP5(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), PON1(1)	18492031	37	34	36	5	14	4	5	7	7	0	0.0232	0.296	1.000
48	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(2), AKT1(3), ASAH1(1), GNAI1(1), GNB1(1), GNGT1(1), ITGAV(3), MAPK1(1), PDGFA(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), PLCB1(3), PRKCA(2), PTK2(2), RAC1(1), SMPD2(2)	17311642	39	32	37	5	10	10	4	13	2	0	0.0137	0.297	1.000
49	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST3A1(1), XYLT1(5), XYLT2(1)	4088694	9	9	9	1	4	2	0	1	2	0	0.122	0.301	1.000
50	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST3A1(1), XYLT1(5), XYLT2(1)	4088694	9	9	9	1	4	2	0	1	2	0	0.122	0.301	1.000
51	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(3), EXTL1(2), EXTL3(2), GLCE(1), HS3ST3A1(1), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(2), NDST4(5)	12992531	24	22	24	3	5	5	4	7	3	0	0.0379	0.306	1.000
52	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), DPEP1(2), LTC4S(1), PLA2G2A(1), PLA2G6(1), PTGIS(1), PTGS1(2), PTGS2(3), TBXAS1(1)	9440901	13	13	13	1	4	3	0	5	1	0	0.0506	0.322	1.000
53	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRA(1), IL10(1), IL4(1)	2503107	3	3	3	0	3	0	0	0	0	0	0.339	0.339	1.000
54	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS2(1), SULT1E1(2), SUOX(1)	3858135	6	6	6	0	3	1	0	1	1	0	0.208	0.339	1.000
55	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(1), NR3C1(1), PPARG(1), TNF(1)	3662617	5	5	5	1	1	0	1	1	2	0	0.599	0.347	1.000
56	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1), TYMS(1)	11305908	16	16	16	2	3	4	0	6	3	0	0.147	0.348	1.000
57	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(1)	1413334	2	2	2	0	0	0	0	0	2	0	0.475	0.355	1.000
58	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(2)	6445680	11	11	11	2	5	2	1	2	1	0	0.192	0.355	1.000
59	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1), CFLAR(1), PDE6D(1)	2445738	3	3	3	1	1	1	0	0	1	0	0.727	0.356	1.000
60	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(2), GRB2(1), PRKCA(2), PTPRA(3)	5799749	9	8	9	1	5	2	0	2	0	0	0.148	0.366	1.000
61	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(2), H6PD(2), PFKL(2), PFKM(2), PFKP(2), PGM1(1), PGM3(2), PRPS1L1(3), RBKS(2), TKT(1), TKTL2(2)	15314228	21	21	21	2	4	3	5	4	5	0	0.0277	0.372	1.000
62	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), LPO(1), MPO(1), TPO(3)	5254445	7	7	7	1	4	2	0	1	0	0	0.228	0.379	1.000
63	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25B(2), CDK7(1), SHH(2)	5479984	7	7	7	1	4	0	2	1	0	0	0.258	0.392	1.000
64	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(3), EIF4E(1), GSK3B(1), IGF1R(2), PDK2(1), PDPK1(1), PIK3CA(12), PIK3R1(1), PPP2CA(1)	11897751	23	22	21	4	3	6	3	9	2	0	0.155	0.396	1.000
65	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(2), MTMR6(1), NFS1(1), THTPA(3)	4037756	7	7	7	2	2	0	2	1	2	0	0.518	0.398	1.000
66	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(2)	2053152	3	3	3	1	2	0	0	1	0	0	0.705	0.405	1.000
67	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	968455	1	1	1	0	0	1	0	0	0	0	0.718	0.410	1.000
68	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), HLA-DRA(1), IL4(1), IL6(1)	3372181	4	4	4	1	3	1	0	0	0	0	0.452	0.422	1.000
69	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(3), CHST12(1), PAPSS2(1), SULT1A1(2), SULT1E1(2), SUOX(1)	5812377	12	11	12	3	7	1	1	1	2	0	0.314	0.422	1.000
70	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), ARHGEF1(4), F2(1), F2R(1), F2RL3(1), GNA13(1), GNAI1(1), GNB1(1), GNGT1(1), MAP3K7(2), PIK3CA(12), PIK3R1(1), PLCB1(3), PRKCA(2), ROCK1(5)	16267934	38	33	36	6	10	6	6	13	3	0	0.0642	0.423	1.000
71	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(1), ATIC(2), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(2), SHMT1(1), SHMT2(1), TYMS(1)	11954096	16	16	16	2	3	4	0	6	3	0	0.148	0.423	1.000
72	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(1)	1647641	2	2	2	0	0	1	0	1	0	0	0.512	0.427	1.000
73	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(3), DPYS(2), ENPP1(2), ENPP3(1), PANK1(2), PANK2(2), PANK3(1)	8794087	14	14	13	3	2	3	3	2	4	0	0.401	0.443	1.000
74	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), GRB2(1), IGF1R(2), IRS1(2), MAPK1(1), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), YWHAH(1)	11724581	27	24	25	5	7	7	4	8	1	0	0.132	0.444	1.000
75	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10(1), IL10RA(2), IL1A(1), IL6(1), JAK1(3), STAT1(1), STAT3(6), TNF(1)	7684828	17	14	17	4	4	3	2	5	3	0	0.254	0.447	1.000
76	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2)	1330392	2	2	2	0	0	0	0	1	1	0	0.810	0.450	1.000
77	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	PLCB1(3), PRKCA(2), RELA(2)	5186468	7	7	7	0	2	2	1	2	0	0	0.0910	0.453	1.000
78	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), HLA-DRA(1)	1916272	2	2	2	0	2	0	0	0	0	0	0.472	0.463	1.000
79	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), CS(2), HAO1(2), MTHFD1(2), MTHFD1L(1)	8082551	9	9	9	0	1	2	3	3	0	0	0.0508	0.475	1.000
80	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(1), MEF2A(1), MEF2C(2), MEF2D(1), YWHAH(1)	4805920	9	8	9	2	5	1	1	2	0	0	0.331	0.479	1.000
81	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), LEPR(1), PRKAA2(4), PRKAG1(2)	9150437	12	12	12	2	3	1	4	4	0	0	0.253	0.481	1.000
82	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11B2(2), HSD11B1(1), HSD3B1(1), HSD3B2(1)	4353432	5	5	5	0	1	0	1	0	3	0	0.192	0.481	1.000
83	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), EHHADH(5)	7651023	14	14	13	4	5	1	2	4	2	0	0.468	0.483	1.000
84	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1)	3569775	4	4	4	0	2	0	1	1	0	0	0.223	0.485	1.000
85	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(2), CTH(1), GOT1(1), GOT2(1), LDHAL6A(1), LDHC(1), SULT4A1(1)	7915293	9	9	9	0	4	1	0	2	2	0	0.0917	0.491	1.000
86	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(2), B3GALT5(2), FUT1(1), FUT2(1), FUT3(1)	4556289	7	7	7	2	1	2	1	3	0	0	0.558	0.494	1.000
87	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B3(1), HSD17B4(3), HSD17B7(1), HSD3B1(1), HSD3B2(1)	5108450	9	9	9	3	2	2	2	0	3	0	0.515	0.494	1.000
88	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), GOT1(1), GOT2(1), LDHC(1)	4328511	5	5	5	0	2	1	0	1	1	0	0.259	0.497	1.000
89	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR3(1), PAK1(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), RAC1(1)	8471486	18	17	17	4	5	3	3	6	1	0	0.389	0.498	1.000
90	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(1)	2141192	2	2	2	0	0	1	0	1	0	0	0.592	0.523	1.000
91	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(2), H6PD(2), PFKM(2), PFKP(2), PGM1(1), PGM3(2), PRPS1L1(3), RBKS(2), TKT(1)	12883723	17	17	17	2	3	2	5	4	3	0	0.0975	0.523	1.000
92	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1)	6372354	7	7	7	1	1	0	1	3	2	0	0.431	0.526	1.000
93	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), CS(2), HAO1(2), MTHFD1(2), MTHFD1L(1)	8462618	9	9	9	0	1	2	3	3	0	0	0.0510	0.533	1.000
94	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), CYP1A2(1), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2J2(1), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), RDH12(1)	15076152	22	19	22	3	7	1	2	8	4	0	0.118	0.538	1.000
95	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK12(1), MAPK8IP3(3), MAPKAPK5(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), SYT1(1), TRAF2(4), TRAF5(1)	21179103	39	34	38	5	12	6	2	11	8	0	0.0182	0.539	1.000
96	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK2(1), HK3(2), IMPA1(1), PGM1(1), PGM3(2)	7343587	11	11	11	2	5	2	1	2	1	0	0.179	0.542	1.000
97	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), ILVBL(2), LARS(2), LARS2(2), PDHA2(3), VARS(3), VARS2(2)	11701457	16	14	16	2	3	2	1	7	3	0	0.191	0.550	1.000
98	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(3), PON3(1), RDH12(1)	5673409	9	7	9	1	3	0	2	3	1	0	0.197	0.551	1.000
99	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP5(1), ACPT(3), ENPP1(2), ENPP3(1), RFK(1), TYR(2)	6129908	11	11	10	3	3	1	1	2	4	0	0.529	0.554	1.000
100	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(3), CDKN1A(2), MAPK1(1), PAK1(1), PIK3CA(12), PIK3R1(1), RAC1(1), RAF1(1), RB1(2), RELA(2), TFDP1(1)	12213886	27	24	25	5	6	6	7	6	1	1	0.112	0.575	1.000
101	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(1)	1493628	1	1	1	0	1	0	0	0	0	0	0.692	0.577	1.000
102	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCAIP(3), UBE2L3(1)	4063206	6	6	6	2	2	0	0	4	0	0	0.670	0.597	1.000
103	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	DCXR(1), UGDH(2), UGP2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2)	17257888	23	21	23	3	4	1	3	11	4	0	0.132	0.599	1.000
104	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCL(1), HMGCS1(1), HMGCS2(1)	4538012	4	4	4	1	1	1	0	2	0	0	0.671	0.607	1.000
105	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), ITPKB(2)	3808991	4	4	4	0	1	1	0	2	0	0	0.266	0.609	1.000
106	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(3), CHST12(1), CHST3(1), CHSY1(1), DSE(1), UST(1), XYLT1(5), XYLT2(1)	8612267	18	18	18	4	9	2	1	3	3	0	0.183	0.618	1.000
107	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), GOT1(1), GOT2(1), PAH(1)	5233585	5	5	5	0	2	1	0	1	1	0	0.177	0.620	1.000
108	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(5), ESR1(2), MAPK1(1), PELP1(2)	9265685	15	14	15	3	8	0	2	2	3	0	0.253	0.623	1.000
109	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(3), AKT2(1), BPNT1(2), GRB2(1), MAPK1(1), PDK1(1), PIK3CA(12), PIK3CD(4), RBL2(2), SHC1(2), SOS1(1)	12362568	30	28	28	7	10	6	4	7	3	0	0.181	0.627	1.000
110	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSB(2), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2)	17192795	24	22	24	3	6	3	2	7	6	0	0.0490	0.628	1.000
111	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(1), CDC25B(2), MYT1(1), YWHAH(1)	4717609	5	5	5	0	3	1	0	1	0	0	0.181	0.632	1.000
112	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PRKCA(2)	3095589	4	4	4	0	1	1	0	1	1	0	0.297	0.641	1.000
113	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(2), ACAT1(1)	3415256	3	3	2	1	2	0	0	1	0	0	0.674	0.643	1.000
114	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR3(1), AKT1(3), DAG1(1), DGKA(1), ETFA(1), ITGA9(3), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), NR1I3(2), PAK1(1), PDE3B(1), PIK3C2G(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PSME1(1), RIPK3(1)	30643300	49	46	47	8	11	10	4	13	11	0	0.0468	0.644	1.000
115	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR1C(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3A(3), POLR3B(1)	14777545	17	17	17	2	6	2	1	6	2	0	0.160	0.663	1.000
116	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), EGFR(3), IGF1R(2), MYC(1), POLR2A(3), PPP2CA(1), PRKCA(2), RB1(2), TEP1(3), TNKS(4)	17217834	24	21	23	2	5	4	3	9	2	1	0.0216	0.667	1.000
117	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(3), MAFF(1), MAPK1(1), PRKCA(2)	5573124	7	7	7	0	3	1	1	2	0	0	0.0839	0.674	1.000
118	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(2), MARCKS(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), SP1(2), SP3(3), SYT1(1)	13226934	17	15	17	1	6	1	1	6	3	0	0.0406	0.675	1.000
119	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(1), ATG7(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), PIK3R4(1), PRKAA2(4), ULK3(1)	13309933	16	16	16	3	5	0	4	5	2	0	0.258	0.682	1.000
120	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), CNR2(1), DNMT1(2), MTNR1A(1), MTNR1B(1), PTGIR(2), TBXA2R(2)	7039962	12	11	12	3	7	3	0	1	1	0	0.128	0.691	1.000
121	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(2)	2874070	2	2	2	1	1	1	0	0	0	0	0.778	0.692	1.000
122	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	GRB2(1), KLK2(1), PIK3CA(12), PIK3R1(1), PLCG1(1), RAF1(1), SHC1(2), SOS1(1)	11712945	20	18	19	4	7	4	3	5	1	0	0.231	0.693	1.000
123	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	MAPK1(1), MYC(1), PLCB1(3), PRKCA(2), RAF1(1), RELA(2), TNF(1)	9524803	11	11	11	1	4	2	2	3	0	0	0.102	0.693	1.000
124	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), MARS2(1), MAT1A(1), PAPSS2(1), SEPHS1(1)	7793024	7	7	7	1	1	2	1	0	3	0	0.350	0.700	1.000
125	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(1), F2R(1), F2RL3(1), GNAI1(1), GNB1(1), GNGT1(1), ITGA1(1), MAPK1(1), PLA2G4A(3), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(2), RAF1(1), SYK(2), TBXAS1(1)	15097592	24	21	24	4	9	5	2	7	1	0	0.0771	0.701	1.000
126	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), UBQLN1(2)	7526117	7	7	7	0	2	1	0	3	1	0	0.115	0.712	1.000
127	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP3K1(1), MAPK1(1), PIK3CA(12), PIK3R1(1), RB1(2), RELA(2), SP1(2)	12241844	24	23	22	5	5	7	4	6	1	1	0.185	0.713	1.000
128	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(2), ALPPL2(2), DHFR(1), SPR(1)	4110961	7	7	7	3	3	2	0	1	1	0	0.615	0.723	1.000
129	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), IL6(1), LDLR(1), LPL(1)	3363478	4	4	4	2	1	1	0	2	0	0	0.795	0.726	1.000
130	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), CTH(1), MUT(1)	3094776	3	3	3	2	1	0	0	0	2	0	0.981	0.735	1.000
131	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR171(1), GPR18(1), GPR68(1), GPR75(1)	6191204	6	6	6	1	2	1	0	3	0	0	0.350	0.737	1.000
132	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CALCRL(1), CD97(1), ELTD1(1), EMR2(5), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GPR64(1), LPHN1(2), LPHN2(3), LPHN3(8), SCTR(1), VIPR1(1)	16744392	32	30	31	7	9	3	4	11	5	0	0.131	0.738	1.000
133	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY2(2), CSNK1E(1), PER1(2)	5342639	5	5	5	1	1	1	1	2	0	0	0.548	0.741	1.000
134	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), CES1(2)	3786245	3	3	3	1	0	0	0	3	0	0	0.845	0.752	1.000
135	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ACADS(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH5A1(1), EHHADH(5), GAD1(2), GAD2(6), HMGCL(1), PDHA2(3), SDHB(1)	16263884	31	31	29	8	12	5	3	6	5	0	0.176	0.757	1.000
136	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(5), LPL(1), NCOA1(2), NCOA2(1), PPARG(1)	11669927	15	15	15	3	5	0	3	5	2	0	0.263	0.761	1.000
137	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(1), ACO2(1), FH(1), SDHB(1)	5083492	4	4	4	0	0	1	2	1	0	0	0.261	0.763	1.000
138	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	SQLE(1)	1988134	1	1	1	1	1	0	0	0	0	0	0.887	0.764	1.000
139	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(4), CREBBP(5), EP300(5), MAP3K7(2), TGFB1(1), TGFB2(2), TGFBR1(2)	16220024	30	27	30	5	7	1	5	6	11	0	0.154	0.768	1.000
140	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), IL4(1), IL6(1), IL7(1), IL9(1)	3830883	5	5	5	2	1	1	1	1	1	0	0.686	0.778	1.000
141	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), DPYD(3), DPYS(2), ENPP1(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(2), PANK3(1)	10923140	16	16	15	4	2	3	3	3	5	0	0.513	0.781	1.000
142	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1)	8462385	8	8	8	1	4	0	1	3	0	0	0.331	0.787	1.000
143	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), CS(2), FH(1), SDHA(1)	5931218	5	5	5	0	0	0	2	3	0	0	0.296	0.791	1.000
144	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA2(1), GLB1(1), HEXB(2), LCT(3), MAN2C1(2), NEU1(1), NEU2(1), NEU4(1)	10424869	15	13	15	4	6	2	1	2	4	0	0.401	0.791	1.000
145	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), UGDH(2), UGP2(1)	3095343	4	4	4	2	1	0	1	2	0	0	0.817	0.794	1.000
146	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(1), CPOX(1), HMBS(1)	4698741	3	3	3	1	1	0	0	2	0	0	0.751	0.806	1.000
147	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(5), DFFA(1), GZMA(1), HMGB2(2), NME1(1), PRF1(1)	6688204	11	11	11	4	3	2	2	1	3	0	0.679	0.810	1.000
148	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1)	5028985	9	9	8	4	3	0	2	3	1	0	0.763	0.811	1.000
149	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1)	5028985	9	9	8	4	3	0	2	3	1	0	0.763	0.811	1.000
150	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(1), FSHR(1), GNAS(2)	6025226	7	6	7	2	2	0	2	3	0	0	0.699	0.813	1.000
151	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(1), MPO(1), TPO(3), TYR(2)	6070417	9	9	9	3	6	2	0	1	0	0	0.446	0.816	1.000
152	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1)	4982734	4	4	4	0	1	0	0	2	1	0	0.294	0.818	1.000
153	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCR(1), GRB2(1), MAP2K4(3), MAP3K1(1), MYC(1), PIK3CA(12), PIK3R1(1), RAF1(1), SOS1(1), STAT1(1), STAT5B(1)	17474555	27	25	25	5	6	7	4	10	0	0	0.110	0.821	1.000
154	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	BMPR1B(1), CEBPB(1), EGR1(2), FSHR(1), GJA4(1), INHA(1), LHCGR(1), MLH1(1), NCOR1(8), NRIP1(2), PGR(2), PRLR(1), ZP2(1)	17906494	23	22	23	4	4	2	4	3	10	0	0.250	0.825	1.000
155	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(1)	2615075	2	2	2	0	1	1	0	0	0	0	0.393	0.829	1.000
156	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(9), DLL1(1), FZD1(2), GSK3B(1), NOTCH1(3)	12498712	16	15	16	4	3	2	2	0	9	0	0.319	0.830	1.000
157	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(3), AKT2(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(3), PITX2(1), PLD1(3), PLD2(1), VN1R1(2)	28255145	34	32	33	4	6	8	2	10	8	0	0.0196	0.830	1.000
158	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(2), ACADVL(1), ACSL1(2), EHHADH(5), SLC25A20(1)	10621723	11	11	10	2	5	1	0	2	3	0	0.384	0.841	1.000
159	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(4), MARS2(1), MAT1A(1)	10944985	13	13	13	3	4	2	2	0	5	0	0.276	0.842	1.000
160	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	CDC25A(1), CDC25B(2), MYT1(1), RB1(2), YWHAH(1)	6616952	7	7	7	2	3	1	1	1	0	1	0.522	0.844	1.000
161	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(4), JUND(1)	2360150	6	6	6	4	3	1	1	1	0	0	0.836	0.846	1.000
162	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(1), CRK(1), GNAI1(1), GNB1(1), GNGT1(1), MAPK1(1), PIK3C2G(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(2), RAF1(1), RELA(2)	17042602	30	25	29	5	8	5	5	9	3	0	0.120	0.847	1.000
163	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3)	8000117	8	7	8	2	2	0	0	3	3	0	0.555	0.849	1.000
164	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(1), ALOX15(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2J2(1), CYP4F2(2), CYP4F3(1), DHRS4(1), GPX4(1), GPX6(1), LTC4S(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PTGIS(1), PTGS1(2), PTGS2(3), TBXAS1(1)	24485619	37	36	37	6	11	6	2	12	6	0	0.0323	0.853	1.000
165	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCG2(2), BCHE(2), CES1(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1)	14430185	11	11	11	0	2	1	1	4	3	0	0.0768	0.854	1.000
166	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(3), TYK2(1)	6628280	8	7	8	2	0	1	1	3	3	0	0.546	0.856	1.000
167	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(3), TYK2(1)	6628280	8	7	8	2	0	1	1	3	3	0	0.546	0.856	1.000
168	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), CS(2), FH(1), IDH3A(1), IDH3B(1), PC(1), PDHA2(3), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(1), SDHB(1), SDHC(2)	17836648	21	20	21	3	2	5	2	7	5	0	0.0876	0.859	1.000
169	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), CS(2), ME1(2), PC(1)	5821959	6	6	6	2	0	1	1	2	2	0	0.607	0.860	1.000
170	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(3), MAP3K1(1), NCOR2(4), THRA(2)	10833818	12	12	12	2	5	0	0	5	2	0	0.280	0.860	1.000
171	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATR(2), YWHAH(1)	5640615	3	3	3	1	1	1	0	1	0	0	0.813	0.861	1.000
172	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGTR1(2), BDKRB2(1), NOS3(2)	6160421	8	7	8	2	3	2	0	2	1	0	0.431	0.862	1.000
173	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(1), GCNT2(2), ST8SIA1(1)	3864391	5	5	5	5	0	2	1	0	2	0	0.950	0.870	1.000
174	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(2), GOT1(1), GOT2(1), PAH(1), YARS2(2)	5481400	7	6	7	2	4	1	0	1	1	0	0.434	0.874	1.000
175	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	RELA(2), TNFRSF13B(2), TRAF2(4), TRAF5(1)	9133933	9	8	9	2	3	2	1	2	1	0	0.327	0.874	1.000
176	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(1)	1946930	1	1	1	1	0	1	0	0	0	0	0.891	0.875	1.000
177	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(2), GLB1(1), HEXB(2), LCT(3)	8995979	10	9	10	2	4	2	0	3	1	0	0.288	0.876	1.000
178	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(2), DBH(5), GAD1(2), GAD2(6), HDC(1), MAOA(2), PAH(1), PNMT(1), TPH1(1)	9046733	22	22	22	7	9	3	2	4	4	0	0.366	0.876	1.000
179	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA4(1), ANXA6(2), EDNRA(1), HPGD(1), HSD11B1(1), PLA2G4A(3), PTGIR(2), PTGIS(1), PTGS1(2), PTGS2(3), SCGB1A1(1), TBXAS1(1)	13059878	21	21	21	5	4	4	2	6	5	0	0.261	0.880	1.000
180	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP14(1), MMP9(2)	4447141	3	3	3	0	0	0	1	2	0	0	0.527	0.880	1.000
181	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(2), GOT1(1), GOT2(1), ME1(2), ME3(1), PGK2(2), TKT(1), TKTL2(2)	12697918	12	12	12	2	1	3	2	4	2	0	0.156	0.882	1.000
182	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	DCXR(1), UGDH(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2)	11106869	10	10	10	2	3	0	1	4	2	0	0.453	0.885	1.000
183	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(2), GAD2(6)	3622723	8	8	8	5	3	1	1	1	2	0	0.857	0.887	1.000
184	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), GNGT1(1), HTR2C(2), PLCB1(3), TUB(1)	4523066	8	7	8	3	3	1	1	3	0	0	0.667	0.890	1.000
185	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFB7(1), NDUFS2(1), NDUFV1(1)	4379385	5	5	5	2	1	0	3	1	0	0	0.736	0.891	1.000
186	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(3), AKT2(1), ANKRD6(1), APC(9), AXIN2(2), DACT1(3), DKK1(2), DKK2(2), GSK3A(2), GSK3B(1), LRP1(5), NKD2(1), PTPRA(3), WIF1(2)	24336774	37	32	36	7	8	9	3	7	10	0	0.0537	0.894	1.000
187	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(2), EPOR(1), GRIN1(2), RELA(2), SOD2(1)	7981174	10	8	10	2	5	1	1	1	2	0	0.416	0.898	1.000
188	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(4)	5319687	4	3	4	1	0	1	0	0	3	0	0.906	0.899	1.000
189	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), UGDH(2)	2429614	3	3	3	2	1	0	1	1	0	0	0.869	0.903	1.000
190	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(1), RELA(2), RIPK1(1), TANK(1), TNFAIP3(1), TRAF1(1), TRAF2(4)	14118187	14	13	14	2	6	2	3	2	1	0	0.0940	0.904	1.000
191	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(3), GNAS(2), GNB1(1), GNGT1(1), NOS3(2), NPPA(1), NR3C1(1), PIK3CA(12), PIK3R1(1), RELA(2), SYT1(1)	11235519	27	25	25	7	4	8	3	10	2	0	0.431	0.905	1.000
192	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATR(2), BRCA1(1), CDC25A(1), CDC25B(2), CDKN1A(2), EP300(5), MDM2(1), MYT1(1), PRKDC(7), RPS6KA1(1), YWHAH(1), YWHAQ(1)	21864155	25	21	25	3	12	4	1	6	2	0	0.0599	0.908	1.000
193	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(2), PPAP2B(1)	14607935	22	19	22	4	7	1	1	7	6	0	0.202	0.908	1.000
194	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	3066735	2	2	2	2	0	0	0	1	1	0	0.963	0.908	1.000
195	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BCL2L11(1), CES1(2)	6754969	4	4	4	0	0	1	0	3	0	0	0.400	0.910	1.000
196	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(1), SHMT2(1)	3443301	2	2	2	0	1	1	0	0	0	0	0.409	0.915	1.000
197	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNB1(1), RELA(2), TNFSF11(1)	6974547	4	4	4	0	0	1	1	1	1	0	0.370	0.915	1.000
198	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(1), CRK(1), DOCK1(2), GRB2(1), HGF(3), ITGA1(1), MAP4K1(1), MAPK1(1), MET(2), PAK1(1), PIK3CA(12), PIK3R1(1), PTK2(2), PXN(2), RAF1(1), RAP1A(1), SOS1(1), STAT3(6)	26956553	40	36	39	7	8	7	8	13	4	0	0.0573	0.916	1.000
199	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(1), F2R(1), F3(1), F5(4), F7(2), FGA(5), FGB(2), PROC(2), PROS1(2)	10350837	22	22	22	7	9	2	2	8	1	0	0.467	0.917	1.000
200	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(2), PDHA2(3)	4373588	6	6	6	3	2	1	0	1	2	0	0.639	0.919	1.000
201	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(1), HMBS(1)	4805719	2	2	2	1	1	0	0	1	0	0	0.842	0.920	1.000
202	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(2), ITGAL(3), ITGAM(2), ITGB2(2), SELE(1), SELP(3)	10018265	13	12	13	4	5	1	4	3	0	0	0.413	0.920	1.000
203	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(4), HEXB(2), HK2(1), HK3(2), PGM3(2)	10663435	11	11	11	3	5	2	0	2	2	0	0.443	0.922	1.000
204	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADSB(2), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(3), DPYS(2), EHHADH(5), GAD1(2), GAD2(6)	18328048	32	30	31	9	10	4	6	6	6	0	0.300	0.926	1.000
205	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(3), APAF1(1), PRKCA(2), PTK2(2), PXN(2), STAT1(1), TLN1(2)	12826965	13	11	12	1	3	4	0	4	2	0	0.0727	0.928	1.000
206	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(3), CCR4(1), CCR7(2), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3), TGFB1(1), TGFB2(2)	12532081	17	16	17	4	2	0	2	10	3	0	0.422	0.929	1.000
207	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(3), EDNRA(1), EGF(2), EGFR(3), MYC(1), PLCG1(1), PRKCA(2), RELA(2)	12677183	15	15	15	4	3	1	2	8	1	0	0.466	0.931	1.000
208	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(1), HMGB2(2), TOP2A(2), TOP2B(2)	5618063	7	7	7	3	1	1	1	1	3	0	0.920	0.932	1.000
209	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1)	2676285	2	2	2	4	0	0	0	1	1	0	0.992	0.933	1.000
210	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CDKN1A(2), CDKN2A(1), CFL1(1), MDM2(1)	4548283	5	4	5	2	2	0	0	0	3	0	0.823	0.934	1.000
211	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(2), EGF(2), EGFR(3), GRB2(1), MET(2), PDGFRA(2), PRKCA(2), SH3GLB2(1)	12251351	16	15	16	4	5	0	3	8	0	0	0.351	0.936	1.000
212	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR1(2), CMA1(2), COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(3), COL4A5(2), COL4A6(1)	15719706	17	16	17	4	4	3	1	4	5	0	0.366	0.938	1.000
213	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(4), GNA13(1), GNB1(1), GNGT1(1), MYLK(4), PLCB1(3), PRKCA(2), ROCK1(5)	13036661	23	21	22	6	4	4	4	9	2	0	0.406	0.938	1.000
214	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CFLAR(1), MAP2K4(3), MAP3K3(1), MAP3K7(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TRAF2(4)	17126105	19	18	19	4	5	2	1	7	4	0	0.288	0.939	1.000
215	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CITED2(1), CPT1B(1), CREBBP(5), DUSP1(1), EHHADH(5), EP300(5), HSD17B4(3), LPL(1), MAPK1(1), ME1(2), MYC(1), NCOA1(2), NCOR1(8), NCOR2(4), NR2F1(1), NRIP1(2), PDGFA(1), PIK3CA(12), PIK3R1(1), PPARA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PTGS2(3), RB1(2), RELA(2), SP1(2), STAT5B(1), TNF(1)	39850152	75	61	74	13	22	13	9	17	13	1	0.00631	0.941	1.000
216	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1)	3488141	1	1	1	0	0	0	0	0	1	0	1.000	0.941	1.000
217	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(3), ITGAM(2), ITGB2(2), SELE(1)	6507440	8	7	8	3	4	1	1	2	0	0	0.560	0.942	1.000
218	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(2), TERF2IP(1)	6045527	7	7	7	3	1	1	1	1	3	0	0.903	0.942	1.000
219	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	THBS1(2)	4672027	2	2	2	0	1	0	1	0	0	0	0.467	0.944	1.000
220	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	BCAR1(1), CTNNA1(1), CTNNA2(4), PTK2(2), PXN(2)	11021619	10	9	10	1	4	1	1	2	2	0	0.214	0.945	1.000
221	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(2), PFKL(2)	5829043	4	4	4	3	1	0	0	0	3	0	0.873	0.946	1.000
222	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(1), RELA(2), TNFAIP3(1)	11398434	7	7	7	1	3	2	1	0	1	0	0.224	0.946	1.000
223	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA2(1), PSMA6(1), PSMB6(1)	5523028	3	3	3	0	0	0	0	2	1	0	0.681	0.947	1.000
224	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1), NAT6(1)	16387724	15	15	15	2	4	1	0	5	5	0	0.237	0.948	1.000
225	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD8A(1), IL6(1)	3904311	3	3	3	3	1	1	0	0	1	0	0.876	0.948	1.000
226	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1(2), MST1R(3), TNF(1)	4130517	6	5	6	3	4	1	0	0	1	0	0.789	0.948	1.000
227	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), IKBKB(1), IL4(1), MAP3K1(1), MAP3K5(1), RELA(2), TRAF2(4)	12189465	12	11	12	3	6	1	1	4	0	0	0.439	0.949	1.000
228	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	RELA(2)	5611782	2	2	2	1	0	1	1	0	0	0	0.742	0.950	1.000
229	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP5(1), ACPT(3), ENPP1(2), ENPP3(1), MTMR2(2), MTMR6(1), RFK(1), TYR(2)	9495845	14	14	13	5	3	1	2	3	5	0	0.647	0.951	1.000
230	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	GRB2(1), SHC1(2), SOS1(1)	5261982	4	4	4	2	3	1	0	0	0	0	0.733	0.951	1.000
231	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	GRB2(1), IGF1R(2), IRS1(2), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1)	15309242	22	19	21	5	6	4	4	7	1	0	0.308	0.951	1.000
232	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGTR1(2), ATF2(2), EGFR(3), GRB2(1), MAP2K4(3), MAP3K1(1), MAPK1(1), MEF2A(1), MEF2C(2), MEF2D(1), PAK1(1), PRKCA(2), PTK2(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1)	20728836	28	26	28	5	13	2	3	9	1	0	0.0958	0.951	1.000
233	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(2), EGFR(3), TF(1)	8116688	8	8	8	3	1	1	0	6	0	0	0.793	0.952	1.000
234	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(1), RAC1(1), WASF1(1)	5126289	4	4	4	2	0	1	1	2	0	0	0.837	0.952	1.000
235	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	DNM1(1), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(3), SYNJ2(2), SYT1(1)	13693947	15	15	15	4	3	1	2	7	2	0	0.499	0.954	1.000
236	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1)	3549467	7	7	7	4	3	2	0	1	1	0	0.770	0.955	1.000
237	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA2(1), PSMA6(1), PSMB6(1), PSMC2(1), PSMD1(1), PSMD2(1), PSMD6(1)	10120211	7	7	7	0	2	0	0	4	1	0	0.254	0.956	1.000
238	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1), NAT6(1)	10461086	9	9	9	2	2	0	0	3	4	0	0.570	0.957	1.000
239	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT2(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	6757191	13	13	13	5	6	4	0	1	2	0	0.540	0.958	1.000
240	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(1), FUT3(1)	3209586	3	3	3	2	0	2	0	1	0	0	0.818	0.959	1.000
241	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(2), EGFR(3), GRB2(1), JAK1(3), MAP2K4(3), MAP3K1(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6)	23307535	40	34	39	9	10	6	4	18	2	0	0.196	0.959	1.000
242	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(1), CDKN1A(2), MDM2(1), PCNA(1), RB1(2)	6962457	7	5	7	2	2	1	1	0	2	1	0.499	0.961	1.000
243	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), AKT1(3), IGF1R(2), IL3RA(2), PIK3CA(12), PIK3R1(1), PRKAR1A(1), PRKAR1B(2), YWHAH(1)	13851802	26	23	24	7	6	6	4	10	0	0	0.294	0.962	1.000
244	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR1B(1), BMPR2(1)	3943685	3	3	3	2	0	0	0	2	1	0	0.978	0.962	1.000
245	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(3), STAT1(1), STAT2(1), TYK2(1)	6842380	7	6	7	3	0	1	0	3	3	0	0.844	0.963	1.000
246	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(3), STAT1(1)	5198245	4	3	4	2	0	1	0	2	1	0	0.852	0.964	1.000
247	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(1), ACO2(1), CS(2), FH(1), IDH3A(1), IDH3B(1), PC(1), SDHA(1), SDHB(1)	12426498	10	10	10	2	1	1	3	4	1	0	0.397	0.965	1.000
248	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(1), PRKCA(2)	4213350	3	3	3	1	2	0	0	1	0	0	0.710	0.966	1.000
249	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(2), DNMT3B(4), MARS2(1), MAT1A(1)	13034318	14	14	14	4	4	2	2	1	5	0	0.379	0.969	1.000
250	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	RIPK1(1), TNF(1), TRAF2(4)	5242010	6	5	6	3	3	0	1	2	0	0	0.710	0.970	1.000
251	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BIK(1), BIRC2(1), DFFA(1)	8496863	4	4	4	0	0	2	0	1	1	0	0.354	0.971	1.000
252	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), CD38(1), ENPP1(2), ENPP3(1), NADK(2), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5C1B(1), NT5C2(2), NT5E(1), NT5M(1), NUDT12(2)	13584014	20	18	20	6	6	3	1	5	5	0	0.441	0.972	1.000
253	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(2), GLB1(1), HEXB(2), LCT(3), SPAM1(3)	12832398	13	12	13	3	6	2	0	4	1	0	0.348	0.974	1.000
254	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(1), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1R(2), MEF2A(1), MEF2C(2), MEF2D(1), NFATC1(1), NFATC2(2), PIK3CA(12), PIK3R1(1), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1)	21877281	35	28	33	6	11	6	5	12	1	0	0.0487	0.975	1.000
255	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(2), B4GALT2(2), B4GALT5(1), ST3GAL1(2)	4953558	7	6	7	3	5	0	0	2	0	0	0.803	0.975	1.000
256	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH12(1)	3008732	1	1	1	1	1	0	0	0	0	0	0.894	0.976	1.000
257	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK3(1), MAPK1(1), STAT3(6), TYK2(1)	7384234	12	11	12	6	1	2	1	5	3	0	0.887	0.976	1.000
258	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1)	8353949	9	9	9	4	3	0	3	2	1	0	0.730	0.976	1.000
259	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(9), CREBBP(5), FZD1(2), GSK3B(1), MAP3K7(2), MYC(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(3), WIF1(2)	17508512	28	26	28	7	7	2	4	3	12	0	0.361	0.977	1.000
260	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), ASAH1(1), CERK(1), CREB3(1), DAG1(1), EPHB2(3), ITPKB(2), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK8IP3(3)	18008709	28	26	28	7	8	4	0	4	12	0	0.319	0.977	1.000
261	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRA(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL1A(1), IL4(1), IL6(1), IL7(1), PDGFA(1), TGFB1(1), TGFB2(2), TNF(1)	8374689	14	13	14	5	5	2	2	3	2	0	0.529	0.977	1.000
262	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), BTK(1), EEA1(2), GSK3A(2), GSK3B(1), PDPK1(1), PFKL(2), PFKM(2), PFKP(2), PLCG1(1), PRKCZ(2), RAC1(1), VAV2(2)	15772748	22	22	21	5	3	5	2	8	4	0	0.174	0.978	1.000
263	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), EP300(5), NOS3(2), VHL(2)	10686093	12	10	12	3	6	1	1	3	1	0	0.435	0.978	1.000
264	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	GRB2(1), HLA-DRA(1), ITK(1), PIK3CA(12), PIK3R1(1)	8098614	16	14	15	5	6	3	2	5	0	0	0.559	0.979	1.000
265	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY2(2), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(2), PER2(2), PER3(2)	10752630	11	10	11	3	2	2	1	4	2	0	0.559	0.980	1.000
266	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP3(1), ARFGEF2(1), COPA(1), GBF1(4), GPLD1(1), KDELR3(1)	10248926	9	9	9	3	4	2	1	1	1	0	0.466	0.980	1.000
267	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(3), GOT1(1)	4918779	4	4	4	4	1	0	0	2	1	0	0.971	0.982	1.000
268	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), HDAC5(2), MEF2A(1), MEF2C(2), MEF2D(1), PPARA(2), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1)	12695233	19	16	19	5	9	1	1	6	2	0	0.388	0.982	1.000
269	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(1), FUT2(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1)	6364479	10	10	10	5	4	4	0	0	2	0	0.721	0.983	1.000
270	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(1), ENPP1(2), ENPP3(1), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5E(1), NT5M(1)	9176221	13	13	13	5	3	2	1	4	3	0	0.600	0.984	1.000
271	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	GRB2(1), JAK1(3), MAP2K4(3), MAP3K1(1), PDGFA(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6)	21688869	38	31	37	9	12	7	4	13	2	0	0.172	0.984	1.000
272	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1), NAT6(1)	15754167	13	11	13	2	4	0	1	4	4	0	0.269	0.984	1.000
273	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(5), FAH(1), GOT1(1), GOT2(1), HGD(1), HPD(1), MAOA(2), PNMT(1), TPO(3), TYR(2)	19902512	29	29	29	8	11	4	3	5	6	0	0.294	0.984	1.000
274	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	RB1(2), TFDP1(1)	5149986	3	3	3	2	0	0	2	0	0	1	0.826	0.985	1.000
275	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS1(1), GSK3B(1), PPP2CA(1)	5810178	3	3	3	4	0	0	0	1	2	0	0.997	0.985	1.000
276	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(2), ARHGDIB(1), CASP1(2), PRF1(1)	8154739	7	7	7	3	2	2	0	2	1	0	0.755	0.985	1.000
277	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	RB1(2), TFDP1(1)	5211707	3	3	3	2	0	0	2	0	0	1	0.811	0.985	1.000
278	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6V1A(2), ATP6V1B1(2), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	8921244	7	7	7	2	1	2	0	2	2	0	0.693	0.986	1.000
279	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6V1A(2), ATP6V1B1(2), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	8921244	7	7	7	2	1	2	0	2	2	0	0.693	0.986	1.000
280	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6V1A(2), ATP6V1B1(2), ATP6V1F(1), ATP6V1H(1), SHMT1(1)	8921244	7	7	7	2	1	2	0	2	2	0	0.693	0.986	1.000
281	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATR(2), BRCA1(1), BRCA2(7), FANCA(2), FANCD2(2), FANCF(1), FANCG(1), HUS1(1), RAD17(1), RAD51(1)	23395675	19	19	19	3	2	1	1	8	7	0	0.511	0.986	1.000
282	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C3(1), AKR1C4(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2F1(2), CYP2S1(2), CYP3A43(1), CYP3A7(1), EPHX1(2), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2)	36238305	60	51	60	10	15	5	10	22	8	0	0.0295	0.986	1.000
283	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(5), DAXX(1), PAX3(3), PML(3), RB1(2), SIRT1(2), SP100(2), TNF(1)	11190621	19	17	19	6	7	2	5	3	1	1	0.392	0.987	1.000
284	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(2), GOT1(1), GOT2(1), ME1(2), ME3(1), TKT(1)	11350016	8	8	8	2	0	2	1	4	1	0	0.414	0.987	1.000
285	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA2(1), PSMA6(1), PSMB6(1), RPN1(1)	8138177	4	4	4	1	1	0	0	2	1	0	0.752	0.987	1.000
286	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSD(1), ARSE(2), ASAH1(1), GAL3ST1(2), GLB1(1), LCT(3), NEU1(1), NEU2(1), NEU4(1), PPAP2A(2), PPAP2B(1), SMPD2(2), SPTLC1(1)	15185762	21	19	21	6	7	3	3	6	2	0	0.321	0.987	1.000
287	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL1A(1), IL6(1), IL9(1), TGFB1(1), TGFB2(2)	5207087	7	7	7	6	1	1	3	1	1	0	0.953	0.987	1.000
288	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(2), AKT1(3), CAMK2A(1), CAMK2D(1), GNAS(2), GRB2(1), MAPK1(1), PIK3CA(12), PIK3R1(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2), RAC1(1), RPS6KA1(1), RPS6KA5(3), SOS1(1)	18092276	35	31	33	9	10	7	3	15	0	0	0.309	0.987	1.000
289	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(2), GHR(1), GRB2(1), IRS1(2), MAPK1(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(1), SHC1(2), SOS1(1), STAT5B(1)	20601029	29	26	28	6	10	6	3	9	1	0	0.172	0.988	1.000
290	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), RB1(2), TFDP1(1)	5381609	4	4	4	3	0	1	2	0	0	1	0.844	0.988	1.000
291	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12A(1), IL12B(1), IL12RB2(1), STAT4(4), TYK2(1)	9194009	8	8	8	3	0	0	1	3	4	0	0.738	0.988	1.000
292	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(2), DFFA(1), LMNA(2), PRF1(1)	12197547	9	9	9	2	3	2	0	2	2	0	0.492	0.988	1.000
293	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC1(1), APOBEC3B(2), APOBEC3G(1)	4637147	6	6	6	4	3	1	0	1	1	0	0.911	0.989	1.000
294	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(3), PTPRU(3), STAT1(1), STAT2(1), TYK2(1)	7890248	10	9	10	5	2	1	0	4	3	0	0.868	0.989	1.000
295	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	GRB2(1), IRS1(2), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1)	15729505	20	18	19	5	6	4	3	6	1	0	0.380	0.989	1.000
296	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(1), PAK1(1), PIK3CA(12), PIK3R1(1), RAC1(1), SYK(2), VAV1(3)	11733265	22	21	21	7	7	3	3	8	1	0	0.647	0.989	1.000
297	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), UGDH(2)	5363995	7	7	7	5	1	0	3	2	1	0	0.945	0.990	1.000
298	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	GRB2(1), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), STAT5B(1)	18654548	29	24	28	6	8	6	4	10	1	0	0.167	0.990	1.000
299	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(2), CYP2A6(2)	5043725	5	5	5	3	3	0	1	0	1	0	0.857	0.990	1.000
300	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(2), GCK(4), GMDS(1), GMPPB(1), HK2(1), HK3(2), MPI(1), PFKFB1(2), PFKFB4(1), PFKM(2), PFKP(2), PMM1(1)	14990664	20	20	20	6	6	1	3	6	4	0	0.313	0.991	1.000
301	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(1), AKT1(3), AKT2(1), BTK(1), CDKN2A(1), GRB2(1), GSK3A(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(1), PIK3CA(12), PPP1R13B(1), RPS6KA1(1), SHC1(2), SOS1(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	22251869	35	32	33	9	9	8	3	10	5	0	0.222	0.992	1.000
302	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), NFATC1(1), NFATC2(2), PRKAR1A(1), PRKAR1B(2)	7641119	7	7	7	3	3	0	1	3	0	0	0.674	0.992	1.000
303	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(2), ITGAL(3), ITGB2(2), SELE(1)	7614889	8	7	8	4	3	0	2	3	0	0	0.787	0.992	1.000
304	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CFLAR(1), DAXX(1), DFFA(1), FAF1(4), LMNA(2), MAP2K4(3), MAP3K1(1), MAP3K7(2), PAK1(1), PAK2(1), PRKDC(7), PTPN13(1), RB1(2), RIPK2(2), SPTAN1(1)	25584967	31	27	31	5	12	4	4	5	5	1	0.0725	0.992	1.000
305	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), EIF2AK4(1), GSK3B(1), PPP1CA(1)	7291496	7	7	7	3	1	0	2	2	2	0	0.687	0.992	1.000
306	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	EGR1(2), KLK2(1), MAPK1(1), RAF1(1)	4899157	5	5	5	5	2	0	1	1	1	0	0.989	0.992	1.000
307	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(4), BRCA1(1), CDKN1A(2), MDM2(1), RAD51(1), RELA(2)	14370346	11	7	11	0	3	1	2	2	3	0	0.0765	0.992	1.000
308	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(2), DIAPH1(1), GSN(1), ITGA1(1), MAPK1(1), MYLK(4), PFN1(1), PIK3CA(12), PIK3R1(1), PTK2(2), PXN(2), RAF1(1), ROCK1(5), SHC1(2), TLN1(2)	23318008	38	33	36	9	10	6	6	11	5	0	0.263	0.993	1.000
309	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(1), GRB2(1), IL6(1), IL6ST(6), JAK1(3), JAK3(1), RAF1(1), SHC1(2), SOS1(1), STAT3(6)	14687574	23	21	23	7	4	6	2	5	6	0	0.564	0.993	1.000
310	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA2(1), GLB1(1), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MAN2C1(2), NEU1(1), NEU2(1), NEU4(1)	12850470	18	14	18	5	8	2	1	3	4	0	0.367	0.993	1.000
311	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C6(4), C9(2)	7932261	8	8	8	4	2	1	0	3	2	0	0.827	0.993	1.000
312	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCL11(1), CFL1(1), GNAS(2), GNB1(1), GNGT1(1), LIMK1(2), MAPK1(1), PIK3C2G(1), PLCB1(3), PRKCA(2), PTK2(2), RAF1(1)	15477768	18	14	18	3	5	2	1	8	2	0	0.337	0.993	1.000
313	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOX1(2), BCAT1(1), BCKDHA(1), EHHADH(5), HADHB(1), HMGCL(1), IVD(2), MCCC1(1), MUT(1)	22713993	32	30	30	9	10	3	4	8	7	0	0.353	0.993	1.000
314	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(1), GRB2(1), MAP2K4(3), MAP3K1(1), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYT1(1)	17631124	17	16	17	4	9	1	2	3	2	0	0.352	0.993	1.000
315	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CYP2C19(3), CYP2C9(2), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1), NAT6(1)	19489756	24	24	24	6	8	2	2	6	6	0	0.362	0.994	1.000
316	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(3), GLI2(3), GLI3(2), GSK3B(1), PRKAR1A(1), PRKAR1B(2), SHH(2), SUFU(1)	10491516	17	15	17	6	4	1	2	7	3	0	0.610	0.994	1.000
317	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(3), COL4A5(2), COL4A6(1), SLC23A2(1), SLC2A1(1)	15604099	14	12	14	4	5	3	0	1	5	0	0.509	0.994	1.000
318	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), DAXX(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1), TNF(1)	7147926	8	8	8	6	2	1	1	2	2	0	0.969	0.994	1.000
319	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(2), MTA1(2)	6807655	5	5	5	6	2	1	0	0	2	0	0.968	0.994	1.000
320	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(2), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(5), EHMT2(1), PLOD1(1), PLOD3(2), SHMT1(1), SHMT2(1)	23306071	31	29	30	7	8	3	6	9	5	0	0.202	0.994	1.000
321	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), POLR2A(3), PRKAR1A(1), PRKAR1B(2)	8104129	7	6	7	3	5	0	0	2	0	0	0.663	0.995	1.000
322	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(4), PPP1CA(1), PPP2CA(1), PRKAG1(2)	11480864	13	13	13	6	0	0	3	6	4	0	0.875	0.995	1.000
323	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	RELA(2), TNF(1)	6207357	3	3	3	2	1	1	1	0	0	0	0.792	0.995	1.000
324	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(2), GOT1(1), GOT2(1), HPD(1), LPO(1), MAOA(2), MPO(1), TPO(3)	13746373	17	17	17	5	5	4	1	4	3	0	0.529	0.995	1.000
325	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1)	8817902	8	8	8	5	0	0	1	4	3	0	0.948	0.995	1.000
326	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKAG1(2)	6365045	3	3	3	2	0	0	2	1	0	0	0.861	0.996	1.000
327	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK4(2), SYT1(1)	7272061	8	8	8	4	4	0	0	3	1	0	0.851	0.996	1.000
328	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), RPL10A(3), RPL12(1), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL3L(1), RPL7(1), RPL8(1), RPS11(2), RPS9(2)	14179867	17	17	17	4	4	2	0	8	3	0	0.480	0.996	1.000
329	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX15(1), CYP4F2(2), CYP4F3(1), EPX(2), LPO(1), MPO(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PTGIS(1), PTGS1(2), PTGS2(3), TBXAS1(1), TPO(3)	17536159	24	24	24	6	8	6	0	8	2	0	0.181	0.996	1.000
330	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT1(2), B4GALT2(2), GAA(1), GALK1(1), GALK2(1), GALT(1), GANAB(1), GCK(4), GLB1(1), HK2(1), HK3(2), LCT(3), MGAM(6), PFKM(2), PFKP(2), PGM1(1), PGM3(2)	20440216	33	29	32	8	15	3	3	7	5	0	0.108	0.996	1.000
331	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(9), AR(2), ASAH1(1), DAG1(1), EGFR(3), GNAI1(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), KCNJ5(1), MAPK1(1), PHKA2(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PITX2(1), RAF1(1)	32594607	56	53	54	13	13	9	4	16	14	0	0.166	0.996	1.000
332	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), CAPNS1(1), EP300(5), MEF2D(1), NFATC1(1), NFATC2(2), PPP3CA(1), PPP3CC(1), PRKCA(2), SYT1(1)	15370361	16	13	16	3	8	0	2	6	0	0	0.195	0.996	1.000
333	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), DPM1(1), MAN1A1(2), MGAT5(1), RPN1(1), ST6GAL1(1)	12527646	12	11	12	3	5	2	0	5	0	0	0.439	0.996	1.000
334	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(1), DHRS7(1), DHRSX(1), HEMK1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1)	9466136	11	11	11	5	1	0	1	5	4	0	0.834	0.996	1.000
335	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(2), CAMK1G(1), FPR1(2), GNB1(1), GNGT1(1), MAP3K1(1), MAPK1(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(2), PAK1(1), PIK3C2G(1), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(2), SYT1(1)	23719895	28	23	28	5	10	2	4	9	3	0	0.141	0.996	1.000
336	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), IKBKB(1), IRAK1(1), LY96(1), MAP2K4(3), MAP3K1(1), MAP3K7(2), PPARA(2), RELA(2), TLR10(1), TLR4(1), TLR7(1), TLR9(1)	22850683	18	15	18	3	11	1	1	4	1	0	0.124	0.996	1.000
337	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA1(1), CA12(1), CA14(2), CA2(2), CA3(1), CA4(1), CA5A(1), CA6(1), CA8(3), CA9(2), CPS1(3), CTH(1), GLUL(1), HAL(1)	11986150	22	21	22	9	6	4	1	7	4	0	0.701	0.996	1.000
338	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(2), GOSR1(1), SNAP25(2), STX16(1), VAMP1(1), VAMP5(1), VAMP7(1), VTI1A(1)	10501297	11	10	11	3	4	0	1	3	3	0	0.582	0.997	1.000
339	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), HLA-A(1), ITGAL(3), ITGB2(2), PRF1(1)	5503190	8	7	8	6	4	0	0	3	1	0	0.925	0.997	1.000
340	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADS(2), ACADSB(2), ACADVL(1), ACAT1(1), ACOX3(1), ACSL1(2), ACSL6(2), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CPT1B(1), CPT1C(4), EHHADH(5), HADH(1), HADHB(1), HSD17B4(3)	30890285	38	31	37	7	13	4	7	6	8	0	0.0484	0.997	1.000
341	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(1), JAK1(3), JAK3(1), STAT1(1), STAT3(6), STAT5B(1), TYK2(1)	11567240	16	14	16	7	0	3	2	7	4	0	0.806	0.997	1.000
342	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(1), GPX4(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(1)	10842023	10	10	10	4	2	1	2	5	0	0	0.734	0.997	1.000
343	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(2), MBTPS2(1), SCAP(1), SREBF2(1)	7503922	7	7	7	6	1	0	0	4	2	0	0.992	0.997	1.000
344	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(9), CREBBP(5), EP300(5), FZD1(2), GSK3B(1), LEF1(2), PITX2(1), TRRAP(2)	19933118	27	26	27	8	9	2	4	3	9	0	0.363	0.997	1.000
345	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX3(1), ELOVL6(1), FASN(2), SCD(1)	8950370	7	7	7	4	0	0	2	2	3	0	0.939	0.997	1.000
346	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), CNDP1(2), DPYD(3), DPYS(2), EHHADH(5), GAD1(2), GAD2(6)	17020004	26	26	26	9	8	4	5	4	5	0	0.538	0.998	1.000
347	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(1), ABCB4(1), ABCC3(2)	9031807	8	8	8	5	2	1	1	2	2	0	0.917	0.998	1.000
348	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD8A(1), ITGAL(3), ITGB2(2), PTPRC(7)	6781513	13	12	13	7	5	1	2	4	1	0	0.764	0.998	1.000
349	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(1), CCNE2(1), CDKN2A(1)	5398206	3	3	3	2	0	1	0	1	1	0	0.848	0.998	1.000
350	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(1), ACO1(1), ACO2(1), ACSS1(1), ACSS2(1), FH(1)	7837950	6	6	6	3	0	1	2	2	1	0	0.783	0.998	1.000
351	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT3(1), B3GNT4(2), B4GALT1(2), B4GALT2(2), FUT1(1), FUT2(1), FUT3(1), GCNT2(2), ST3GAL6(1), ST8SIA1(1)	10194983	14	12	14	6	3	3	1	4	2	1	0.735	0.998	1.000
352	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(1), EPRS(3), GARS(1), IARS(1), KARS(1), LARS(2), LARS2(2), MARS2(1), QARS(1), SARS(1), TARS(1), WARS(1)	20236338	18	16	18	4	5	3	2	5	3	0	0.378	0.998	1.000
353	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(3)	5837300	4	4	4	3	1	1	1	0	1	0	0.866	0.998	1.000
354	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(7), PLCB1(3), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKAR1A(1), PRKAR1B(2)	10117049	17	16	16	7	6	2	0	6	3	0	0.693	0.998	1.000
355	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(2), ENO1(2), GCK(4), HK2(1), HK3(2), LDHC(1), PDHA2(3), PFKM(2), PFKP(2), PGM1(1), PGM3(2)	30787491	37	35	36	8	13	3	6	9	6	0	0.0803	0.998	1.000
356	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(2), ENO1(2), GCK(4), HK2(1), HK3(2), LDHC(1), PDHA2(3), PFKM(2), PFKP(2), PGM1(1), PGM3(2)	30787491	37	35	36	8	13	3	6	9	6	0	0.0803	0.998	1.000
357	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(2), IL12A(1), IL12B(1), IL12RB2(1), STAT4(4), TYK2(1)	11696510	10	10	10	4	1	1	1	3	4	0	0.705	0.999	1.000
358	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2I(1), UBE2L3(1), UBE2N(1)	6638844	4	4	4	3	1	1	0	1	1	0	0.945	0.999	1.000
359	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(1), IL4(1), IL4R(3), IRS1(2), JAK1(3), JAK3(1), SHC1(2), STAT6(2)	9269593	18	16	17	7	5	3	0	7	3	0	0.745	0.999	1.000
360	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	LSS(1), NQO1(1), SQLE(1)	6910272	3	3	3	4	2	0	0	0	1	0	0.967	0.999	1.000
361	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), PDE1B(1), PLCB1(3)	7013960	6	6	6	4	2	1	1	1	1	0	0.822	0.999	1.000
362	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(3), GALNT3(2), GALNT4(2), GALNT8(2), GCNT1(1), ST3GAL1(2), WBSCR17(1)	9090780	13	12	13	7	6	1	0	4	2	0	0.915	0.999	1.000
363	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(1), L1CAM(6), SELP(3)	9933649	16	15	16	7	5	0	3	5	3	0	0.750	0.999	1.000
364	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(3), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), IGF1R(2), KLK2(1), MAPK1(1), MYC(1), PDGFRA(2), PPP2CA(1), RAF1(1), RPS6KA1(1), RPS6KA5(3), SHC1(2), SOS1(1), STAT3(6)	20502397	30	28	30	8	7	3	3	14	3	0	0.426	0.999	1.000
365	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), HLA-DRA(1), ITGAL(3), ITGB2(2), PTPRC(7)	9552824	14	13	14	6	6	1	2	5	0	0	0.705	0.999	1.000
366	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(3), ACE2(1), AGTR1(2), ANPEP(1), CMA1(2), CTSG(1), ENPEP(1), LNPEP(1), MAS1(1), MME(2), THOP1(1)	13324683	16	14	16	5	5	3	1	6	1	0	0.480	0.999	1.000
367	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(3), PLA2G2A(1), PTPRU(3), STAT1(1)	7254010	8	7	8	4	2	1	0	4	1	0	0.839	0.999	1.000
368	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CBS(1), CTH(1), HEMK1(1), LCMT2(1), MARS2(1), MAT1A(1), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), PRMT8(1), SEPHS1(1), SEPHS2(3)	15706354	18	18	18	6	2	2	3	5	6	0	0.638	0.999	1.000
369	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS2(3), ENPP7(1), GAL3ST1(2), GLB1(1), LCT(3), NEU1(1), NEU2(1), NEU4(1), PPAP2A(2), PPAP2B(1), SGMS1(1), SMPD2(2), SMPD3(1), SMPD4(1), SPHK2(1), SPTLC1(1)	22389729	29	22	29	8	12	4	5	5	3	0	0.192	0.999	1.000
370	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA2(1), GALNS(2), GLB1(1), HEXB(2), LCT(3), MAN2B1(2), MAN2B2(1), MAN2C1(2), NEU1(1), NEU2(1), NEU4(1), SPAM1(3)	21625146	25	20	25	6	12	2	1	6	4	0	0.249	0.999	1.000
371	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(3), JAK3(1), PIAS3(1), PTPRU(3), STAT3(6)	9596020	15	13	15	7	2	3	2	6	2	0	0.836	0.999	1.000
372	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PGAP1(1), PIGA(1), PIGB(2), PIGH(1), PIGO(2), PIGQ(3)	14985492	11	10	11	3	2	1	2	4	2	0	0.569	0.999	1.000
373	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(1), ACTG1(2), ARHGEF2(3), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTTN(1), KRT18(1), LY96(1), PRKCA(2), ROCK1(5), TLR4(1), TLR5(2), TUBA1A(1), TUBA3C(4), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(1), YWHAQ(1), YWHAZ(1)	32050447	45	36	44	8	12	3	3	17	10	0	0.111	0.999	1.000
374	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(1), ACTG1(2), ARHGEF2(3), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTTN(1), KRT18(1), LY96(1), PRKCA(2), ROCK1(5), TLR4(1), TLR5(2), TUBA1A(1), TUBA3C(4), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1), WAS(1), YWHAQ(1), YWHAZ(1)	32050447	45	36	44	8	12	3	3	17	10	0	0.111	0.999	1.000
375	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP2K4(3), MAP3K1(1), MAPK1(1), NSMAF(2), RAF1(1), RELA(2), RIPK1(1), TRAF2(4)	12895336	15	14	15	5	5	2	3	5	0	0	0.505	0.999	1.000
376	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(2), ENO1(2), GCK(4), GOT1(1), GOT2(1), HK2(1), HK3(2), LDHC(1), PC(1), PDHA2(3), PDHX(1), PFKL(2), PFKM(2), PFKP(2), PGK2(2)	26759011	27	26	27	6	8	4	3	5	7	0	0.0915	0.999	1.000
377	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(1)	14638961	21	20	20	8	6	1	5	6	3	0	0.627	0.999	1.000
378	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), CES1(2), DDHD1(3), ESCO1(4), ESCO2(1), NAT6(1)	15938151	13	13	13	4	2	0	2	6	3	0	0.696	0.999	1.000
379	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	BTG1(1), CEBPB(1), CRY2(2), EIF4G2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(4), NCOA4(3), NR1D2(2), PER1(2), PER2(2), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(2), ZFR(1)	23033120	29	25	29	8	3	2	5	11	8	0	0.658	1.000	1.000
380	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(2), C3(2), C6(4), C8B(1), C9(2), MASP1(3)	13092940	14	14	14	5	4	1	3	4	2	0	0.572	1.000	1.000
381	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(4), ATR(2), CCNA1(1), CDC25A(1), CDKN1A(2), CDKN2A(1), DHFR(1), GSK3B(1), RB1(2), TFDP1(1), TGFB1(1), TGFB2(2)	14371861	19	15	19	8	5	1	5	2	5	1	0.766	1.000	1.000
382	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	DHFR(1), POLD1(1), POLG(1)	7870560	3	3	3	5	1	1	0	0	1	0	0.994	1.000	1.000
383	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), CYP19A1(2), HEMK1(1), HSD11B1(1), HSD17B3(1), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2)	31646959	45	40	45	10	8	5	6	15	11	0	0.150	1.000	1.000
384	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(1), CFLAR(1), DFFA(1), LMNA(2), RELA(2), RIPK1(1), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(2), TNFSF12(1), TRAF2(4)	21001997	18	17	18	4	4	5	2	5	2	0	0.251	1.000	1.000
385	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(2), C3(2), C6(4), C9(2)	11012540	10	10	10	5	2	1	2	3	2	0	0.797	1.000	1.000
386	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GPRC5B(1), GRM1(7), GRM3(2), GRM4(1), GRM5(3), GRM7(1), GRM8(2)	13250265	19	19	18	8	10	1	1	3	4	0	0.594	1.000	1.000
387	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	HMGCS1(1), LSS(1), SQLE(1)	8248968	3	3	3	6	1	0	0	1	1	0	0.998	1.000	1.000
388	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), CASP1(2), ITCH(1), MAGI2(1), RERE(2), WWP1(2)	15131799	9	9	9	3	2	1	1	3	2	0	0.658	1.000	1.000
389	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(5), ACADSB(2), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), EHHADH(5), LDHC(1), MUT(1)	20896553	24	22	23	7	8	2	4	7	3	0	0.469	1.000	1.000
390	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(1), HEXB(2), LCT(3), SLC33A1(1), ST3GAL1(2), ST6GALNAC4(1), ST8SIA1(1)	10405168	16	14	16	8	7	3	1	3	2	0	0.758	1.000	1.000
391	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(2), C3(2), C6(4), C9(2), MASP1(3), MASP2(1)	13407948	14	14	14	5	3	1	3	5	2	0	0.599	1.000	1.000
392	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), FCER1A(1), GRB2(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAPK1(1), NFATC1(1), NFATC2(2), PAK2(1), PIK3CA(12), PIK3R1(1), PLA2G4A(3), PLCG1(1), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3)	26829880	44	38	43	10	16	6	4	16	2	0	0.173	1.000	1.000
393	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL4(1), ITGAX(2), TLR4(1), TLR7(1), TLR9(1)	11747252	11	11	11	6	4	1	0	3	3	0	0.807	1.000	1.000
394	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	IKBKB(1), RB1(2), RELA(2), TNF(1)	10893065	6	6	6	3	2	1	2	0	0	1	0.685	1.000	1.000
395	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BCL2A1(1), CASP1(2), CD40(1), CD40LG(1), DAXX(1), DFFA(1), FAS(1), FASLG(1), IKBKE(1), MCL1(1), NR3C1(1), NTRK1(4), PTPN13(1), RIPK1(1), TFG(1), TNF(1), TRAF1(1), TRAF2(4)	27372393	26	23	26	5	9	6	2	5	4	0	0.112	1.000	1.000
396	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), ITPKB(2), OCRL(3), PIK3C2A(1), PIK3C2B(2), PIK3C2G(1), PIK3CA(12), PIK3CB(3), PIK3CG(4), PLCB1(3), PLCG1(1), PLCG2(2)	26578922	35	30	34	8	11	8	5	8	3	0	0.143	1.000	1.000
397	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(5), DUSP1(1), EP300(5), IKBKB(1), MAP3K7(2), NR3C1(1), RELA(2), TGFBR1(2), TNF(1)	18683279	20	18	20	5	9	1	4	3	3	0	0.353	1.000	1.000
398	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP6V1A(2), ATP6V1B1(2), ATP6V1F(1), ATP6V1H(1), FDXR(1), SHMT1(1)	9518938	8	8	8	4	2	2	0	2	2	0	0.894	1.000	1.000
399	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLE(4), POLG(1), POLL(1), POLQ(5)	10548249	12	11	12	5	4	2	2	2	2	0	0.764	1.000	1.000
400	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	GRB2(1), IL3RA(2), RAF1(1), SHC1(2), SOS1(1), STAT5B(1)	10881437	8	8	8	4	4	2	2	0	0	0	0.708	1.000	1.000
401	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ACADS(2), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH5A1(1), DDHD1(3), EHHADH(5), GAD1(2), GAD2(6), HADH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), ILVBL(2), PDHA2(3), RDH12(1)	25527900	39	37	38	11	14	6	5	7	7	0	0.231	1.000	1.000
402	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), LRP8(1), RELN(4), VLDLR(2)	8854542	9	9	9	5	2	1	2	3	1	0	0.902	1.000	1.000
403	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), EBP(1), GGCX(1), HSD17B7(1), LSS(1), NQO1(1), SQLE(1), TM7SF2(1)	12055935	10	10	10	7	4	2	1	0	3	0	0.913	1.000	1.000
404	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCND3(1), CCNH(1), CDC25A(1), CDK7(1), CDKN1A(2), CDKN2A(1), RB1(2), TFDP1(1)	9902984	11	9	11	6	3	1	3	2	1	1	0.785	1.000	1.000
405	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(2), CYP2A6(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(4), CYP2C9(2), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), EHHADH(5), KMO(1), KYNU(3), MAOA(2), TDO2(1), TPH1(1), WARS(1)	34679565	56	50	55	14	18	5	8	14	11	0	0.244	1.000	1.000
406	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), JAK3(1), PIAS3(1), PTPRU(3), SOAT1(1)	8656734	9	8	9	6	2	1	1	4	1	0	0.959	1.000	1.000
407	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AOC2(1), ASPA(1), CNDP1(2), HAL(1), HDC(1), MAOA(2)	15328963	18	17	17	9	4	3	2	5	4	0	0.919	1.000	1.000
408	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG12(1), ALG14(2), ALG5(1), B4GALT1(2), B4GALT2(2), DPM1(1), GANAB(1), MAN1A1(2), MAN1C1(1), MAN2A1(3), MGAT5(1), MGAT5B(2), RFT1(1), RPN1(1), ST6GAL1(1)	26535444	22	18	22	4	7	2	2	5	6	0	0.262	1.000	1.000
409	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(1), NTRK1(4), RAC1(1), WASF1(1), WASF2(1), WASF3(1)	9630885	10	10	10	6	0	5	1	3	1	0	0.898	1.000	1.000
410	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(3), COL4A5(2), COL4A6(1), F10(2), F11(4), F12(1), F2(1), F2R(1), F5(4), F8(1), FGA(5), FGB(2), KLKB1(1), PROC(2), PROS1(2), SERPING1(1)	27844691	39	38	39	11	12	6	2	10	9	0	0.395	1.000	1.000
411	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT1(2), B4GALT2(2), G6PC2(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANC(2), GCK(4), GLB1(1), HK2(1), HK3(2), LCT(3), MGAM(6), PFKL(2), PFKM(2), PFKP(2), PGM1(1), PGM3(2), RDH12(1), UGP2(1)	24263061	39	34	38	10	16	3	4	9	7	0	0.0975	1.000	1.000
412	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(1), GRB2(1), MAP3K1(1), MAPK1(1), MAPK8IP3(3), PAPPA(3), RAC1(1), RPS6KA1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3), VAV2(2), VAV3(3)	19854274	27	25	27	9	10	2	3	9	3	0	0.495	1.000	1.000
413	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF2(1)	11511472	6	6	6	3	0	2	0	3	1	0	0.846	1.000	1.000
414	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), CDC16(1), CDC20(1), CDC23(1), CDC27(1), CUL2(3), CUL3(3), FBXW11(2), FZR1(2), ITCH(1), SMURF2(1), TCEB2(1), UBA1(1), VHL(2), WWP1(2)	25264267	30	29	30	8	2	3	8	10	7	0	0.437	1.000	1.000
415	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(1), GRB2(1), GSK3A(2), GSK3B(1), IL4R(3), IRS1(2), IRS2(2), JAK1(3), JAK3(1), MAP4K1(1), MAPK1(1), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), STAT6(2)	23046940	46	40	44	13	13	7	3	14	9	0	0.372	1.000	1.000
416	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(2), FASN(2)	9872549	9	9	9	7	1	1	1	5	1	0	0.979	1.000	1.000
417	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), EPX(2), ESCO1(4), ESCO2(1), GOT1(1), GOT2(1), HPD(1), LPO(1), MAOA(2), MPO(1), NAT6(1), TPO(3)	21480448	23	23	23	7	6	4	1	6	6	0	0.633	1.000	1.000
418	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP5(2), ARHGAP6(2), ARHGEF1(4), ARHGEF11(2), ARHGEF5(3), CFL1(1), DIAPH1(1), GSN(1), LIMK1(2), MYLK(4), PFN1(1), PIP5K1B(1), ROCK1(5), TLN1(2)	28327121	32	30	31	8	3	5	5	9	10	0	0.478	1.000	1.000
419	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(1), ARHGEF11(2), DLG4(1), GNA13(1), LPA(2), MAP2K4(3), MAP3K1(1), MAP3K5(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(1), PHKA2(1), PIK3CB(3), PLD1(3), PLD2(1), PTK2(2), ROCK1(5), TBXA2R(2)	30951419	36	31	34	8	8	7	4	10	7	0	0.164	1.000	1.000
420	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(2), GAD2(6), GOT1(1), GOT2(1), PC(1)	16417070	18	18	18	9	5	3	2	3	5	0	0.868	1.000	1.000
421	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1F(1), ATP6V1H(1), ATP7A(1), ATP7B(1), COX7A1(1), COX7C(1), NDUFA10(2), NDUFB7(1), NDUFS2(1), NDUFV1(1), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(1)	23510764	22	21	22	5	4	6	3	7	2	0	0.263	1.000	1.000
422	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	PLCG1(1), PRKCA(2), SYT1(1)	8672791	4	4	4	2	3	0	0	1	0	0	0.743	1.000	1.000
423	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	APC(9), ATF2(2), BMP4(1), BMP5(3), BMP7(3), BMPR1A(1), BMPR2(1), CHRD(1), FZD1(2), GSK3B(1), MAP3K7(2), MEF2C(2), NPPA(1), RFC1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR3(1)	21938575	36	30	36	10	7	5	7	6	11	0	0.300	1.000	1.000
424	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(2), EGFR(3), GRB2(1), MAPK1(1), PTPRB(2), RAF1(1), SHC1(2), SOS1(1), SPRY3(1)	15462977	15	15	15	5	5	1	1	7	1	0	0.681	1.000	1.000
425	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(3), AKT2(1), BRD4(3), CAP1(1), CBL(1), CDKN2A(1), FLOT1(1), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(2), IRS4(3), LNPEP(1), MAPK1(1), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PTPN1(1), RAF1(1), RPS6KA1(1), SHC1(2), SORBS1(3), SOS1(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	37056110	54	46	52	11	13	9	5	15	12	0	0.0931	1.000	1.000
426	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(2), ESR1(2), NR1D1(1), NR1D2(2), NR1I2(2), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR3C1(1), NR4A2(1), NR5A2(1), PGR(2), PPARA(2), PPARD(1), PPARG(1), RARB(2), ROR1(1), RXRB(3), RXRG(1), THRA(2)	26288353	34	30	33	9	19	2	5	3	5	0	0.193	1.000	1.000
427	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(1), BCR(1), BTK(1), CD81(2), DAG1(1), FLOT1(1), GRB2(1), GSK3A(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(7), ITPR3(3), MAP4K1(1), MAPK1(1), NFATC1(1), NFATC2(2), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PLCG2(2), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(7), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3)	46637650	72	65	70	17	23	8	9	20	12	0	0.0942	1.000	1.000
428	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA2(4), PRKAG1(2), PRKAR1A(1), PRKAR1B(2)	9650587	16	15	16	7	4	0	2	9	1	0	0.882	1.000	1.000
429	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), DFFA(1), LMNA(2), MADD(2), MAP2K4(3), MAP3K1(1), MAP3K7(2), PAK1(1), PAK2(1), PRKDC(7), RB1(2), RIPK1(1), SPTAN1(1), TNF(1), TRAF2(4)	24309009	30	27	30	8	13	3	2	7	4	1	0.350	1.000	1.000
430	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKQ(1), DGKZ(2), GK(1), GLB1(1), LCT(3), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(1), PPAP2A(2), PPAP2B(1)	30232801	44	36	43	10	14	4	6	11	9	0	0.109	1.000	1.000
431	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(4), CPOX(1), EPRS(3), HMBS(1), HMOX2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2)	17309506	18	18	18	6	6	1	1	7	3	0	0.629	1.000	1.000
432	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(5), ACAT1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), LDHC(1), ME1(2), ME3(1), PC(1), PDHA2(3)	23291823	23	23	22	7	6	3	3	8	3	0	0.430	1.000	1.000
433	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(3), NAGS(1), PYCR1(1)	10999717	12	12	12	7	6	0	1	4	1	0	0.865	1.000	1.000
434	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CYB5R1(1), GFPT2(2), GNPNAT1(1), HEXB(2), HK2(1), HK3(2), MTMR2(2), MTMR6(1), NAGK(1), PGM3(2)	18055590	15	15	15	7	3	2	1	5	4	0	0.838	1.000	1.000
435	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR3(1), MAP3K1(1), MYC(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), RELA(2), SYT1(1)	17633832	15	14	15	5	5	1	2	6	1	0	0.530	1.000	1.000
436	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(3), ASAH1(1), CREB3(1), CREBBP(5), DAG1(1), EGR1(2), EGR3(1), FRS2(1), MAP1B(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK8IP3(3), NTRK1(4), PIK3C2G(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), SHC1(2), TERF2IP(1)	31260037	51	45	49	15	15	11	3	12	10	0	0.268	1.000	1.000
437	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), ALAS2(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CPT1B(1), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), MAOA(2), PISD(1), PLCG1(1), PLCG2(2), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1)	26292753	27	25	27	9	7	3	2	6	9	0	0.763	1.000	1.000
438	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(1), CD79A(1), GRB2(1), MAP3K1(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), SYT1(1), VAV1(3)	23777020	23	22	23	6	12	1	3	7	0	0	0.323	1.000	1.000
439	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), DAG1(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), PDE6B(1), PDE6C(1), PDE6D(1), SLC6A13(2), TF(1)	22523087	23	21	23	8	7	3	1	7	5	0	0.678	1.000	1.000
440	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1R(2), ETS1(1), ETV3(3), HDAC5(2), NCOR2(4), RBL2(2), SIN3B(1)	16012279	15	14	15	5	3	1	5	1	5	0	0.570	1.000	1.000
441	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	GRB2(1), MAP2K4(3), MAP3K1(1), NFATC1(1), NFATC2(2), PIK3CA(12), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCA(2), PTPN7(1), RAC1(1), RAF1(1), RELA(2), SHC1(2), SOS1(1), SYT1(1), VAV1(3), ZAP70(3)	29834614	41	35	40	11	16	6	6	13	0	0	0.232	1.000	1.000
442	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BCL2L11(1), BIRC2(1), BIRC5(2), CASP1(2), DFFA(1), FAS(1), FASLG(1), HELLS(1), IKBKB(1), IRF2(1), IRF3(2), IRF4(2), IRF6(2), MAP2K4(3), MAP3K1(1), MDM2(1), MYC(1), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(2), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF21(4), TRAF1(1), TRAF2(4)	35580091	43	38	43	10	10	5	3	15	10	0	0.243	1.000	1.000
443	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(2), EIF2B2(1), EIF2B3(1), FLT1(3), FLT4(2), KDR(3), NOS3(2), PIK3CA(12), PIK3R1(1), PLCG1(1), PRKCA(2), PTK2(2), PXN(2), SHC1(2), VHL(2)	21129245	38	30	37	10	16	6	2	8	6	0	0.289	1.000	1.000
444	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(3), AKT2(1), BTK(1), FCER1A(1), GAB2(5), GRB2(1), IL4(1), INPP5D(2), LCP2(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MAPK12(1), MS4A2(1), PDK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCG1(1), PLCG2(2), PRKCA(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), SOS1(1), SYK(2), TNF(1), VAV1(3), VAV2(2), VAV3(3)	45186371	82	70	80	20	25	12	8	26	11	0	0.0914	1.000	1.000
445	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(1), BCAR1(1), BCR(1), CAPNS1(1), CAV1(1), GRB2(1), ITGA1(1), MAPK1(1), PTK2(2), PXN(2), RAF1(1), RAP1A(1), ROCK1(5), SHC1(2), SOS1(1), TLN1(2)	29401999	24	22	23	5	6	2	5	6	5	0	0.260	1.000	1.000
446	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(3), F2(1), F2RL3(1), MAPK1(1), PLD1(3), PLD2(1), PTK2(2), RAF1(1), RASAL1(2), VAV1(3)	17268021	20	18	20	7	9	2	1	6	2	0	0.629	1.000	1.000
447	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), CHRM2(2), CHRM4(1), DRD2(1), DRD3(1), HTR1A(3), HTR1D(1), HTR1E(4), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2)	16157160	32	30	32	12	15	4	2	8	3	0	0.369	1.000	1.000
448	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CALML6(1), CAMK2A(1), CAMK2D(1), CLCA1(1), CLCA2(1), CLCA4(1), CNGA3(1), CNGA4(3), CNGB1(1), GNAL(1), GUCA1A(1), PDE1C(3), PRKACA(2), PRKG1(2), PRKX(2)	19223351	23	23	23	9	7	5	3	4	4	0	0.471	1.000	1.000
449	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(1), ACO1(1), ACO2(1), CS(2), FH(1), IDH3A(1), IDH3B(1), PC(1), PCK2(2), SDHA(1), SDHB(1), SDHC(2)	18262873	15	14	15	6	2	1	4	4	4	0	0.707	1.000	1.000
450	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(1), IL1A(1), IRAK1(1), MAP3K1(1), MAP3K7(2), RELA(2), RIPK1(1), TLR4(1), TNF(1), TNFAIP3(1)	15211509	12	12	12	5	6	1	2	1	2	0	0.643	1.000	1.000
451	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(3), MAP3K1(1), MCL1(1), MDM2(1), MYC(1), PARP1(2), PRF1(1), RELA(2), RIPK1(1), TNF(1), TRAF1(1), TRAF2(4)	22990436	23	20	23	7	6	5	2	7	3	0	0.431	1.000	1.000
452	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(3), ATP5A1(2), ATP5G3(1), ATP5J(1), ATP6V0A2(3), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), COX7A1(1), COX7C(1), CYC1(1), NDUFA10(2), NDUFB10(2), NDUFB7(1), NDUFB9(1), NDUFS2(1), NDUFS3(1), NDUFV1(1), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1)	34548427	36	32	36	9	5	7	6	11	7	0	0.252	1.000	1.000
453	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IKBKB(1), IL1A(1), IL1RAP(2), IL6(1), IRAK1(1), IRAK2(3), IRAK3(2), MAP3K1(1), MAP3K7(2), RELA(2), TGFB1(1), TGFB2(2), TNF(1)	18604520	21	20	21	8	10	2	3	3	3	0	0.603	1.000	1.000
454	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(1), ADCY1(2), CAP1(1), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), MAPK1(1), MYT1(1), PRKAR1A(1), PRKAR1B(2), RPS6KA1(1)	12643700	15	15	15	8	3	1	1	9	1	0	0.943	1.000	1.000
455	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(1), ACVR2A(2), ACVRL1(2), BMP4(1), BMP5(3), BMP6(1), BMP7(3), BMP8B(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CHRD(1), COMP(1), CREBBP(5), DCN(2), EP300(5), FST(1), GDF6(1), GDF7(1), INHBA(2), INHBC(2), INHBE(2), LTBP1(4), MAPK1(1), MYC(1), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(5), RPS6KB2(1), SMAD2(2), SMAD3(1), SMAD4(5), SMAD6(2), SMAD9(1), SMURF2(1), SP1(2), TFDP1(1), TGFB1(1), TGFB2(2), TGFBR1(2), THBS1(2), THBS3(1), THBS4(2), TNF(1), ZFYVE16(2), ZFYVE9(1)	62379130	91	79	89	19	22	10	18	27	14	0	0.0312	1.000	1.000
456	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), CAPNS1(1), ITGA1(1), PTK2(2), PXN(2), RAC1(1), SPTAN1(1), TLN1(2)	17980408	11	11	11	4	3	1	1	4	2	0	0.686	1.000	1.000
457	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	EPOR(1), GRB2(1), PLCG1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1)	13194168	8	8	8	4	5	2	1	0	0	0	0.748	1.000	1.000
458	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), CDS1(2), CHAT(2), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKI(5), DGKQ(1), DGKZ(2), ESCO1(4), ESCO2(1), ETNK1(1), GNPAT(1), GPAM(2), NAT6(1), PISD(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLD1(3), PLD2(1), PPAP2A(2), PPAP2B(1)	41125184	50	44	50	10	11	5	4	14	16	0	0.126	1.000	1.000
459	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(1), GPX4(1), GPX6(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTM5(2), GSTO2(1), OPLAH(1)	13334694	12	12	12	5	2	2	2	5	1	0	0.690	1.000	1.000
460	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(1), EEF1A2(2), EEF1D(1), EEF2(2), EEF2K(4), EIF2AK3(4), EIF2B2(1), EIF2B3(1), EIF4A1(1), EIF4E(1), EIF4G1(2), EIF4G3(2), EIF5B(1), PABPC3(1)	27601707	24	23	24	9	6	1	3	6	8	0	0.735	1.000	1.000
461	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CALR(1), CD8A(1), CD8B(2), HLA-A(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), KIR2DL1(1), KIR3DL1(2), NFYA(1), NFYC(2), PSME1(1), RFXAP(1), TAP1(2), TAP2(1)	29198885	33	30	33	10	5	7	6	7	8	0	0.348	1.000	1.000
462	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(9), ASAH1(1), CAV3(1), DAG1(1), DLG4(1), EPHB2(3), GNAI1(1), ITPR1(2), ITPR2(7), ITPR3(3), KCNJ5(1), MAPK1(1), PITX2(1), RAC1(1), RYR1(13)	28849239	50	46	49	15	19	4	2	11	14	0	0.351	1.000	1.000
463	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(5), EP300(5), HDAC3(2), IKBKB(1), RELA(2), RIPK1(1), TNF(1)	14067959	17	17	17	7	7	2	4	3	1	0	0.657	1.000	1.000
464	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	GRB2(1), JAK1(3), JAK3(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2)	14281267	12	11	12	9	5	3	1	2	1	0	0.949	1.000	1.000
465	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(1), AGPAT6(2), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), DAK(1), DGAT1(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKI(5), DGKQ(1), DGKZ(2), GK(1), GLB1(1), GPAM(2), LCT(3), LIPG(3), LPL(1), PNLIP(2), PNLIPRP1(1), PPAP2A(2), PPAP2B(1)	36849539	52	42	52	13	13	5	6	14	14	0	0.200	1.000	1.000
466	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLD1(1), POLD3(1), POLE(4), POLG(1), POLI(1), POLL(1), POLM(1), POLQ(5), PRIM2(1), REV1(1), REV3L(1), RFC5(1)	25520170	20	18	20	8	4	2	3	5	6	0	0.868	1.000	1.000
467	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	IMPA1(1), INPP5B(2), INPP5E(2), IPMK(1), ITPK1(2), ITPKB(2), OCRL(3), PI4KA(3), PI4KB(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(2), PLCZ1(2), SYNJ1(3), SYNJ2(2)	44743676	61	53	60	15	18	11	8	19	5	0	0.0844	1.000	1.000
468	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB3(1), EEF2K(4), EIF4E(1), GRB2(1), MAP3K8(1), MAPK1(1), RAP1A(1), RPS6KA1(1), SHC1(2), SOS1(1)	17645802	14	14	14	6	6	4	1	1	2	0	0.612	1.000	1.000
469	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), RDH12(1), SLC27A5(1), SOAT1(1), SOAT2(1)	19891666	20	19	20	9	5	1	5	6	3	0	0.783	1.000	1.000
470	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(3), AKT2(1), KDR(3), MAPK1(1), MAPK12(1), MAPKAPK3(1), NFATC1(1), NFATC2(2), NOS3(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCG1(1), PLCG2(2), PPP3CA(1), PPP3CC(1), PRKCA(2), PRKCG(1), PTGS2(3), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), SHC2(1), SPHK2(1), VEGFA(2)	45031473	73	56	71	17	21	13	9	16	14	0	0.0511	1.000	1.000
471	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), ATP8A1(1), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR1(1), CCR2(3), CCR4(1), CCR6(1), CCR7(2), CCR8(1), CXCR6(1), EDNRA(1), FPR1(2), FSHR(1), GALT(1), GNRHR(3), LHCGR(1), MC3R(2), MC4R(1), NPY1R(1), NPY2R(2), NPY5R(1), NTSR1(1), OPRL1(1), OPRM1(2), SSTR1(2), SSTR2(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(2), TRHR(1), TSHR(1)	32966457	55	49	54	18	20	6	3	21	5	0	0.266	1.000	1.000
472	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(2), ACOX3(1), ACSL1(2), ACSL6(2), ADIPOQ(1), AQP7(1), CPT1B(1), CPT1C(4), CYP7A1(1), CYP8B1(1), DBI(1), EHHADH(5), FABP2(1), FABP4(1), FABP6(1), GK(1), HMGCS2(1), LPL(1), ME1(2), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(1), PPARG(1), RXRB(3), RXRG(1), SCD(1), SLC27A1(1), SLC27A4(2), SLC27A5(1), SLC27A6(1), SORBS1(3), UBC(1)	41213600	52	44	51	12	18	7	7	10	10	0	0.113	1.000	1.000
473	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), AKR1A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(2), ENO1(2), G6PC2(1), GCK(4), HK2(1), HK3(2), LDHAL6A(1), LDHC(1), PDHA2(3), PFKL(2), PFKM(2), PFKP(2), PGK2(2), PGM1(1), PGM3(2)	36654270	41	39	41	11	12	4	8	8	9	0	0.134	1.000	1.000
474	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(2), CANT1(2), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), NME1(1), NT5E(1), NT5M(1), POLD1(1), POLE(4), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1), TXNRD1(1), TYMS(1), UCK2(2), UMPS(1), UPP1(2)	36082762	42	37	41	11	12	4	10	10	6	0	0.240	1.000	1.000
475	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(1), ACTG1(2), ACVR1B(1), CDH1(4), CREBBP(5), CSNK2A2(1), CTNNA1(1), CTNNA2(4), CTNNA3(1), EGFR(3), EP300(5), ERBB2(3), FARP2(2), FER(1), FGFR1(2), IGF1R(2), IQGAP1(3), LEF1(2), LMO7(1), MAP3K7(2), MAPK1(1), MET(2), MLLT4(2), NLK(1), PTPN1(1), PTPRB(2), PTPRF(2), PTPRM(1), PVRL1(2), PVRL2(2), RAC1(1), RAC2(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(5), SNAI1(1), SORBS1(3), SSX2IP(1), TCF7L1(1), TCF7L2(3), TGFBR1(2), TJP1(1), WAS(1), WASF1(1), WASF2(1), WASF3(1)	74425132	90	78	89	17	24	10	13	30	13	0	0.0118	1.000	1.000
476	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), BCAR1(1), CAPN11(3), CAPN3(1), CAPN5(1), CAPN7(1), CAPNS1(1), CAV1(1), CAV3(1), CRK(1), DOCK1(2), GIT2(1), GRB2(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAD(1), ITGAE(1), ITGAL(3), ITGAM(2), ITGAV(3), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), MAPK12(1), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PDPK1(1), PIK3R2(3), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAPGEF1(3), ROCK1(5), SHC1(2), SHC3(1), SORBS1(3), SOS1(1), TLN1(2), TNS1(6), VAV2(2), VAV3(3)	84215094	110	88	108	21	25	16	10	41	18	0	0.00860	1.000	1.000
477	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(1), ATR(2), BAI1(5), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), FAS(1), GTSE1(2), MDM2(1), MDM4(2), PPM1D(1), RCHY1(1), SERPINB5(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(1), THBS1(2), TNFRSF10B(2), TSC2(4)	36128219	40	37	40	11	14	2	4	13	7	0	0.354	1.000	1.000
478	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(9), CCND3(1), CSNK1E(1), DVL2(2), DVL3(1), FZD1(2), FZD10(3), FZD2(4), FZD5(2), FZD6(3), FZD7(1), FZD9(2), GSK3B(1), LDLR(1), MYC(1), PLAU(2), PPP2R5E(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAC1(1), WNT2(1), WNT5A(1), WNT6(2)	36848739	52	44	52	16	14	6	7	12	13	0	0.261	1.000	1.000
479	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(2), DUSP8(2), GCK(4), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(2), MAP3K3(1), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAP3K9(2), PAPPA(3), SHC1(2)	31233538	39	32	38	11	14	7	3	7	8	0	0.286	1.000	1.000
480	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(2), GCK(4), GYS1(2), HK2(1), HK3(2), MGAM(6), PGM1(1), PGM3(2), PYGL(2), SI(5), UGDH(2), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2B15(2)	35914046	48	43	47	13	11	5	11	10	11	0	0.287	1.000	1.000
481	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	70	ARAF(1), CACNA1A(10), GNA13(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GNAZ(3), GRIA2(4), GRIA3(1), GRID2(6), GRM1(7), GRM5(3), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), IGF1R(2), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), NOS1(3), NOS3(2), NPR1(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCB1(3), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(2), RAF1(1), RYR1(13)	65192157	107	89	106	24	48	7	7	27	18	0	0.0243	1.000	1.000
482	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(2), GNAI1(1), GNAS(2), GNB1(1), GNGT1(1), NFATC1(1), NFATC2(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2), RAF1(1), SYT1(1)	21650903	20	17	20	8	6	0	3	11	0	0	0.765	1.000	1.000
483	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(3), AKT2(1), CDKN2A(1), CREB3(1), EBP(1), ERBB4(2), GRB2(1), GSK3A(2), GSK3B(1), IRS1(2), IRS2(2), IRS4(3), MET(2), MYC(1), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(12), PIK3CD(4), PPP1R13B(1), PTK2(2), PTPN1(1), RPS6KA1(1), SHC1(2), SOS1(1), TSC1(1), TSC2(4), YWHAH(1), YWHAQ(1), YWHAZ(1)	47979248	61	53	59	16	15	10	4	18	14	0	0.241	1.000	1.000
484	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), CCKBR(2), CCR2(3), CELSR1(2), CELSR2(6), CELSR3(2), CHRM2(2), EDNRA(1), EMR2(5), EMR3(1), F2R(1), FSHR(1), GHRHR(1), GNRHR(3), GPR116(1), GPR132(1), GPR133(2), GPR17(2), GPR18(1), GPR55(1), GPR56(1), GPR84(1), GRM1(7), LGR6(1), LPHN2(3), LPHN3(8), NTSR1(1), OR2M4(1), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2)	41896044	68	59	66	22	26	8	8	21	5	0	0.144	1.000	1.000
485	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(2), CANT1(2), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD4(1), ENTPD6(3), NME1(1), NT5C1B(1), NT5C2(2), NT5E(1), NT5M(1), POLA1(1), POLD1(1), POLD3(1), POLE(4), POLR1A(3), POLR1B(2), POLR1C(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3A(3), POLR3B(1), PRIM2(1), RFC5(1), TXNRD1(1), TYMS(1), UCK2(2), UMPS(1), UPP1(2)	50915042	55	51	54	14	16	5	10	16	8	0	0.211	1.000	1.000
486	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(2), ACAA2(1), ACADS(2), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOX1(2), BCAT1(1), BCKDHA(1), DBT(1), EHHADH(5), HADH(1), HADHB(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), IVD(2), MCCC1(1), MUT(1)	27107735	33	33	32	11	10	6	3	7	7	0	0.513	1.000	1.000
487	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(3), AKT2(1), CAB39(1), DDIT4(1), FIGF(1), MAPK1(1), PDPK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PRKAA2(4), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), TSC1(1), TSC2(4), ULK3(1), VEGFA(2)	32463515	53	47	51	16	15	11	7	13	7	0	0.275	1.000	1.000
488	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALML6(1), CDS1(2), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKI(5), DGKQ(1), DGKZ(2), IMPA1(1), INPP5B(2), INPP5D(2), INPP5E(2), ITPK1(2), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), OCRL(3), PI4KA(3), PI4KB(2), PIK3C2A(1), PIK3C2B(2), PIK3C2G(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(1), SYNJ1(3), SYNJ2(2)	76274071	105	84	104	23	30	19	10	28	18	0	0.0207	1.000	1.000
489	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ARHGAP5(2), BCAR1(1), CDH5(5), CLDN10(1), CLDN15(1), CLDN20(1), CLDN23(2), CLDN9(2), CTNNA1(1), CTNNA2(4), CTNNA3(1), CYBB(1), ESAM(1), GNAI1(1), GNAI2(1), ITGA4(2), ITGAL(3), ITGAM(2), ITGB2(2), ITK(1), JAM2(1), MAPK12(1), MLLT4(2), MMP9(2), MSN(1), MYL5(1), NCF1(1), NCF2(3), NCF4(1), NOX3(4), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(1), RAPGEF4(2), RASSF5(1), ROCK1(5), SIPA1(2), VAV1(3), VAV2(2), VAV3(3), VCAM1(1)	77050622	114	91	112	29	34	13	14	32	21	0	0.111	1.000	1.000
490	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(5), CTBP2(1), DLL1(1), DLL3(3), DLL4(2), DTX1(3), DTX2(1), DTX3L(1), DTX4(2), DVL2(2), DVL3(1), EP300(5), JAG2(3), LFNG(1), MAML1(1), MAML2(1), MAML3(1), MFNG(1), NCOR2(4), NCSTN(1), NOTCH1(3), NOTCH2(4), NOTCH3(3), NOTCH4(3), NUMB(1), NUMBL(1), PTCRA(1), RBPJL(1), SNW1(2)	43537140	59	50	59	18	22	7	7	9	14	0	0.330	1.000	1.000
491	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(3), AKT2(1), BCR(1), BTK(1), CDKN2A(1), FLOT1(1), ITPR1(2), ITPR2(7), ITPR3(3), PDK1(1), PIK3CA(12), PITX2(1), PLCG2(2), PPP1R13B(1), PTPRC(7), RPS6KA1(1), SAG(2), SYK(2), VAV1(3)	34283851	52	49	50	16	10	8	7	17	10	0	0.451	1.000	1.000
492	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(3), AKT2(1), ASAH1(1), DAG1(1), DRD2(1), EGFR(3), EPHB2(3), GRB2(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), KCNJ5(1), MAPK1(1), PIK3CB(3), PITX2(1), PLCB1(3), RAF1(1), SHC1(2), SOS1(1), STAT3(6), TERF2IP(1)	34336262	48	45	47	15	11	10	3	16	8	0	0.440	1.000	1.000
493	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(1), BLVRB(1), COX15(1), CP(4), CPOX(1), EPRS(3), FTMT(1), HMBS(1), HMOX2(1), MMAB(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2)	26592912	34	30	34	11	9	2	3	14	6	0	0.596	1.000	1.000
494	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(4), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC20(1), CDC25A(1), CDC25B(2), CDC6(1), CDC7(2), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(2), E2F3(1), EP300(5), ESPL1(2), GSK3B(1), HDAC3(2), HDAC5(2), HDAC6(3), HDAC8(2), MAD1L1(2), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MPEG1(5), PCNA(1), PRKDC(7), PTPRA(3), RB1(2), SMAD4(5), TFDP1(1), TGFB1(1)	64393049	84	65	84	17	23	11	12	24	13	1	0.0262	1.000	1.000
495	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(4), AKT1(3), AKT2(1), ARAF(1), CAMK2A(1), CAMK2D(1), CBL(1), CDKN1A(2), CRK(1), EGF(2), EGFR(3), ERBB2(3), ERBB3(4), ERBB4(2), GRB2(1), GSK3B(1), MAP2K4(3), MAP2K7(3), MAPK1(1), MYC(1), NRG1(5), NRG2(4), NRG3(3), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PLCG2(2), PRKCA(2), PRKCG(1), PTK2(2), RAF1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), STAT5B(1)	63179130	101	80	99	27	34	15	10	26	16	0	0.0892	1.000	1.000
496	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1B(1), ACVRL1(2), AKT1(3), AURKB(2), BMPR1A(1), BMPR2(1), BUB1(1), CDKL2(3), CDS1(2), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A2(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKQ(1), DGKZ(2), IMPA1(1), ITPKB(2), MAP3K10(4), NEK1(2), OCRL(3), PIK3C2A(1), PIK3C2B(2), PIK3C2G(1), PIK3CA(12), PIK3CB(3), PIK3CG(4), PLCB1(3), PLCG1(1), PLCG2(2), PLK3(3), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKG1(2), RAF1(1), RPS6KA1(1), RPS6KA4(2), TGFBR1(2)	69360505	96	73	94	22	26	17	16	25	12	0	0.0354	1.000	1.000
497	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOC(2), FUK(1), GMDS(1), GMPPB(1), HK2(1), HK3(2), MPI(1), MTMR2(2), MTMR6(1), PFKFB1(2), PFKFB4(1), PFKL(2), PFKM(2), PFKP(2), PGM2(2), PMM1(1), RDH12(1), TSTA3(2)	23297037	27	25	27	10	5	2	4	9	7	0	0.483	1.000	1.000
498	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), CABIN1(1), CAMK4(2), CD69(2), CDKN1A(2), CEBPB(1), CNR1(3), CREBBP(5), EGR3(1), EP300(5), FCER1A(1), GSK3A(2), GSK3B(1), IFNB1(1), IL10(1), IL4(1), IL6(1), ITK(1), KPNA5(2), MAP2K7(3), MEF2A(1), MEF2D(1), NFATC1(1), NFATC2(2), NFKBIB(1), NFKBIE(1), NUP214(1), PAK1(1), PPP3CC(1), PTPRC(7), RELA(2), SP1(2), SP3(3), TGFB1(1), TNF(1), TRAF2(4), TRPV6(2), VAV1(3), VAV2(2), VAV3(3), XPO5(1)	57104032	78	63	78	22	26	9	7	25	11	0	0.204	1.000	1.000
499	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1B(1), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(1), AOX1(2), DBH(5), ESCO1(4), ESCO2(1), FAH(1), GOT1(1), GOT2(1), HEMK1(1), HGD(1), HPD(1), LCMT2(1), MAOA(2), METTL6(1), NAT6(1), PNMT(1), PRMT3(2), PRMT5(2), PRMT8(1), TPO(3), TYR(2), TYRP1(1)	37405055	44	41	44	15	12	4	4	12	12	0	0.612	1.000	1.000
500	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(2), ACSL1(2), ACSL6(2), ADIPOQ(1), ADIPOR1(1), ADIPOR2(1), AKT1(3), AKT2(1), CPT1B(1), CPT1C(4), G6PC2(1), IKBKB(1), IRS1(2), IRS2(2), IRS4(3), JAK1(3), JAK3(1), LEPR(1), NFKBIB(1), NFKBIE(1), PCK2(2), POMC(2), PPARA(2), PPARGC1A(3), PRKAA2(4), PRKAG1(2), PRKAG3(1), PRKCQ(1), RELA(2), RXRB(3), RXRG(1), SLC2A1(1), STAT3(6), TNF(1), TRAF2(4), TYK2(1)	52219562	70	55	68	19	24	10	9	17	10	0	0.120	1.000	1.000
501	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(2), B3GALNT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT3(1), B3GNT4(2), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT6(1), FUT1(1), FUT2(1), FUT3(1), GCNT2(2), PIGA(1), PIGB(2), PIGH(1), PIGO(2), PIGQ(3), ST3GAL1(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1)	30548373	39	34	39	13	13	4	5	11	5	1	0.531	1.000	1.000
502	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTR3(1), AKT1(3), AKT2(1), ARHGEF6(1), ARHGEF7(1), BCAR1(1), CAV1(1), CDKN2A(1), CRK(1), CSE1L(1), DOCK1(2), EPHB2(3), GRB2(1), GRB7(2), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), MAP2K4(3), MAP2K7(3), MAP3K11(2), MAPK1(1), MAPK8IP3(3), MRAS(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PIK3CA(12), PIK3CB(3), PLCG1(1), PLCG2(2), PTK2(2), RAF1(1), ROCK1(5), SHC1(2), SOS1(1), TERF2IP(1), TLN1(2), TLN2(3), WAS(1)	75536800	106	80	103	27	22	18	13	32	21	0	0.0984	1.000	1.000
503	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(1), CDS1(2), CHAT(2), CPT1B(1), DGKA(1), DGKB(2), DGKD(3), DGKH(1), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(1), LGALS13(1), PISD(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCG1(1), PLCG2(2), PPAP2A(2), PPAP2B(1)	31278408	35	30	35	12	8	4	6	7	10	0	0.556	1.000	1.000
504	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CREBBP(5), EP300(5), ERCC3(1), ESR1(2), GRIP1(3), HDAC3(2), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(4), NRIP1(2), PELP1(2), POLR2A(3)	28697221	37	30	37	14	15	4	4	7	7	0	0.540	1.000	1.000
505	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), CARS(1), CARS2(2), DARS2(1), EPRS(3), FARSB(2), GARS(1), IARS(1), KARS(1), LARS(2), LARS2(2), MARS2(1), NARS2(1), PARS2(2), QARS(1), SARS(1), TARS(1), TARS2(2), VARS(3), VARS2(2), WARS(1), YARS2(2)	34204104	35	27	35	10	13	3	3	9	7	0	0.510	1.000	1.000
506	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), BBOX1(1), DOT1L(3), EHHADH(5), EHMT2(1), HADH(1), HSD17B4(3), NSD1(2), PLOD1(1), PLOD3(2), RDH12(1), SETD1A(2), SETDB1(2), SHMT1(1), SHMT2(1)	36462542	36	32	36	12	11	6	6	7	6	0	0.454	1.000	1.000
507	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(4), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), ATR(2), BUB1(1), CCNA1(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC16(1), CDC20(1), CDC23(1), CDC25A(1), CDC25B(2), CDC27(1), CDC6(1), CDC7(2), CDK7(1), CDKN1A(2), CDKN2A(1), CREBBP(5), DBF4(1), E2F3(1), EP300(5), ESPL1(2), FZR1(2), GSK3B(1), MAD1L1(2), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), PCNA(1), PRKDC(7), RB1(2), RBL2(2), SMAD2(2), SMAD3(1), SMAD4(5), SMC1A(1), SMC1B(1), TFDP1(1), TGFB1(1), TGFB2(2), YWHAH(1), YWHAQ(1), YWHAZ(1)	80746499	95	73	95	23	25	8	21	24	16	1	0.0801	1.000	1.000
508	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR3(1), AKT1(3), AKT2(1), ARHGEF11(2), BTK(1), CFL1(1), ITPR1(2), ITPR2(7), ITPR3(3), LIMK1(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(12), PIK3CD(4), PIK3CG(4), PIK3R1(1), PITX2(1), PPP1R13B(1), RACGAP1(1), ROCK1(5), SAG(2), WASF1(1)	43627396	69	62	66	22	15	10	7	22	15	0	0.596	1.000	1.000
509	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), DMD(3), MYBPC1(1), MYBPC2(4), MYBPC3(3), MYH6(6), MYH7(4), MYH8(5), MYL1(1), MYOM1(3), NEB(7), TCAP(2), TNNI1(1), TNNT3(1), TPM1(1), TPM4(1), TTN(66)	85441606	110	87	110	26	31	12	18	31	17	1	0.0661	1.000	1.000
510	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AKT1(3), AKT2(1), APAF1(1), BIRC2(1), CFLAR(1), DFFA(1), FAS(1), FASLG(1), IKBKB(1), IL1A(1), IL1RAP(2), IL3RA(2), IRAK1(1), IRAK2(3), IRAK3(2), IRAK4(1), NTRK1(4), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR1A(1), PRKAR1B(2), RELA(2), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10D(1), TRAF2(4)	47987556	75	64	73	24	22	15	8	21	9	0	0.301	1.000	1.000
511	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(1), ACTG1(2), AKT1(3), AKT2(1), ARHGAP5(2), BCAR1(1), BIRC2(1), CAV1(1), CAV3(1), CCND3(1), COL11A2(5), COL1A1(3), COL1A2(3), COL3A1(2), COL4A1(2), COL4A2(3), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(2), COL5A3(3), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), CRK(1), DIAPH1(1), DOCK1(2), EGF(2), EGFR(3), ERBB2(3), FARP2(2), FIGF(1), FLNA(1), FLNB(1), FLNC(3), FLT1(3), FN1(4), GRB2(1), GSK3B(1), HGF(3), IGF1R(2), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAV(3), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), KDR(3), LAMA1(3), LAMA2(4), LAMA3(7), LAMA4(4), LAMA5(2), LAMB1(7), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(4), LAMC2(1), LAMC3(1), MAPK1(1), MET(2), MYL5(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PARVB(1), PARVG(2), PDGFA(1), PDGFD(2), PDGFRA(2), PDGFRB(1), PDPK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIP5K1C(2), PPP1CA(1), PRKCA(2), PRKCG(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(3), RELN(4), ROCK1(5), SHC1(2), SHC2(1), SHC3(1), SOS1(1), THBS1(2), THBS3(1), THBS4(2), TLN1(2), TLN2(3), TNC(2), TNN(3), TNXB(9), VAV1(3), VAV2(2), VAV3(3), VEGFA(2), VWF(4)	228120743	293	188	289	93	91	45	24	83	50	0	0.0781	1.000	1.000
512	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	APC(9), APC2(1), ARAF(1), ARHGEF1(4), ARHGEF6(1), ARHGEF7(1), ARPC5(1), ARPC5L(1), BCAR1(1), BDKRB1(2), BDKRB2(1), CD14(1), CFL1(1), CHRM2(2), CHRM4(1), CRK(1), CYFIP1(2), CYFIP2(4), DIAPH1(1), DIAPH3(2), DOCK1(2), EGF(2), EGFR(3), F2(1), F2R(1), FGD1(1), FGD3(2), FGF10(1), FGF16(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(2), FGFR3(1), FN1(4), GNA13(1), GSN(1), IQGAP1(3), IQGAP2(1), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAD(1), ITGAE(1), ITGAL(3), ITGAM(2), ITGAV(3), ITGAX(2), ITGB2(2), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), LIMK1(2), LIMK2(3), MAPK1(1), MRAS(1), MSN(1), MYH10(6), MYH9(2), MYL5(1), MYLK(4), MYLK2(4), NCKAP1L(5), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDGFA(1), PDGFRA(2), PDGFRB(1), PFN1(1), PFN2(2), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PTK2(2), PXN(2), RAC1(1), RAC2(1), RAC3(1), RAF1(1), ROCK1(5), RRAS2(1), SLC9A1(1), SOS1(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(4), TIAM2(4), VAV1(3), VAV2(2), VAV3(3), WAS(1), WASF1(1), WASF2(1)	172299869	241	177	238	59	67	30	23	82	39	0	0.0110	1.000	1.000
513	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA1(2), ADORA2A(1), ADORA3(2), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2B(1), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(1), C3AR1(1), CALCR(1), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(2), CHRM4(1), CNR1(3), CNR2(1), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD2(1), DRD3(1), EDNRA(1), F2(1), F2R(1), F2RL3(1), FPR1(2), FSHR(1), GABBR2(2), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(4), GABRB2(2), GABRB3(1), GABRD(2), GABRE(2), GABRG1(4), GABRG2(1), GABRP(1), GABRQ(1), GABRR1(1), GABRR2(3), GH1(2), GH2(1), GHR(1), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(2), GLRA2(2), GNRHR(3), GPR156(2), GPR35(1), GPR50(4), GPR83(2), GRIA2(4), GRIA3(1), GRIA4(4), GRID1(4), GRID2(6), GRIK1(2), GRIK2(1), GRIK3(5), GRIK4(2), GRIK5(1), GRIN1(2), GRIN2B(6), GRIN2C(1), GRIN3A(2), GRIN3B(1), GRM1(7), GRM3(2), GRM4(1), GRM5(3), GRM6(1), GRM7(1), GRM8(2), GZMA(1), HCRTR2(4), HTR1A(3), HTR1D(1), HTR1E(4), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LEPR(1), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MCHR1(1), MCHR2(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPY1R(1), NPY2R(2), NPY5R(1), NR3C1(1), NTSR1(1), OPRL1(1), OPRM1(2), P2RX1(1), P2RY1(1), P2RY10(1), P2RY14(1), P2RY4(2), P2RY6(1), P2RY8(1), PRLR(1), PTGIR(2), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(1), SSTR1(2), SSTR2(1), SSTR3(1), SSTR4(1), SSTR5(1), TAAR2(1), TAAR5(1), TAAR6(3), TAAR8(3), TACR1(1), TACR3(2), TBXA2R(2), THRA(2), TRHR(1), TRPV1(1), TSHR(1), VIPR1(1)	136671858	249	173	245	71	111	30	17	62	29	0	0.00144	1.000	1.000
514	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY8(5), ADCY9(3), ADORA2A(1), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(2), ATP2A1(3), ATP2A2(1), ATP2B1(1), ATP2B2(5), ATP2B3(2), ATP2B4(4), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), CACNA1A(10), CACNA1B(1), CACNA1C(2), CACNA1D(4), CACNA1E(13), CACNA1F(2), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(4), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CYSLTR1(1), CYSLTR2(1), EDNRA(1), EGFR(3), ERBB2(3), ERBB3(4), ERBB4(2), F2R(1), GNAL(1), GNAS(2), GRIN1(2), GRIN2C(1), GRM1(7), GRM5(3), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(3), LHCGR(1), MYLK(4), MYLK2(4), NOS1(3), NOS3(2), NTSR1(1), P2RX1(1), PDE1B(1), PDE1C(3), PDGFRA(2), PDGFRB(1), PHKA1(1), PHKA2(1), PHKB(3), PLCB1(3), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(1), PLCG2(2), PLCZ1(2), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RYR1(13), RYR2(14), RYR3(11), SLC8A1(3), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(2), TBXA2R(2), TRHR(1), VDAC1(1)	165243443	255	168	253	108	104	26	19	64	42	0	0.781	1.000	1.000
515	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(1), AKT1(3), AKT2(1), ATF2(2), ATF4(1), BDNF(1), CACNA1A(10), CACNA1B(1), CACNA1C(2), CACNA1D(4), CACNA1E(13), CACNA1F(2), CACNA1G(1), CACNA1H(2), CACNA1I(1), CACNA1S(4), CACNA2D1(2), CACNA2D3(1), CACNA2D4(2), CACNB1(3), CACNB2(2), CACNB4(2), CACNG3(1), CACNG4(1), CACNG5(1), CACNG7(3), CACNG8(1), CD14(1), CDC25B(2), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP7(1), DUSP8(2), ECSIT(2), EGF(2), EGFR(3), FAS(1), FASLG(1), FGF10(1), FGF16(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(2), FGFR3(1), FLNA(1), FLNB(1), FLNC(3), GRB2(1), IKBKB(1), IL1A(1), JUND(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K10(4), MAP3K12(1), MAP3K13(2), MAP3K3(1), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAP3K8(1), MAP4K1(1), MAPK1(1), MAPK12(1), MAPK8IP3(3), MAPKAPK3(1), MAPKAPK5(1), MEF2C(2), MRAS(1), MYC(1), NF1(2), NFATC2(2), NLK(1), NTRK1(4), PAK1(1), PAK2(1), PDGFA(1), PDGFRA(2), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PPM1A(1), PPM1B(1), PPP3CA(1), PPP3CC(1), PPP5C(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(1), PTPN7(1), RAC1(1), RAC2(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(1), RASGRF1(2), RASGRF2(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(1), SOS1(1), STK3(1), STK4(2), TAOK1(1), TAOK2(3), TGFB1(1), TGFB2(2), TGFBR1(2), TNF(1), TRAF2(4)	177403416	216	154	215	85	74	25	23	58	36	0	0.784	1.000	1.000
516	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(2), ATP1B2(1), ATP2A2(1), ATP2B1(1), ATP2B2(5), ATP2B3(2), CACNA1A(10), CACNA1B(1), CACNA1C(2), CACNA1D(4), CACNA1E(13), CACNA1S(4), CACNB1(3), CALR(1), CAMK1(2), CAMK2A(1), CAMK2D(1), CAMK4(2), CHRM2(2), CHRM4(1), GJA1(1), GJA4(1), GJA5(2), GJB2(1), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(3), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK4(1), GRK6(1), ITPR1(2), ITPR2(7), ITPR3(3), KCNB1(4), KCNJ5(1), MIB1(1), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RGS11(1), RGS16(2), RGS3(1), RGS6(2), RGS9(2), RYR1(13), RYR2(14), RYR3(11), SLC8A1(3), SLC8A3(3), YWHAH(1), YWHAQ(1)	117650764	187	136	187	81	84	14	11	49	29	0	0.869	1.000	1.000
517	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(1), ACTG1(2), COL11A2(5), COL17A1(3), COL1A1(3), COL1A2(3), COL3A1(2), COL4A1(2), COL4A2(3), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(2), COL5A3(3), COL6A1(2), COL6A3(7), COL6A6(2), COMP(1), DSC1(1), DSC3(1), DSG1(1), DSG2(3), FN1(4), GJA1(1), GJA4(1), GJA5(2), GJA8(4), GJB2(1), GJB4(1), GJB5(1), GJC2(1), ITGA6(2), ITGB4(2), KRT1(1), KRT12(1), KRT14(1), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT23(2), KRT24(1), KRT25(4), KRT27(2), KRT28(1), KRT3(1), KRT31(2), KRT33A(1), KRT38(2), KRT39(1), KRT4(2), KRT5(1), KRT6A(1), KRT6C(4), KRT7(1), KRT73(1), KRT75(1), KRT77(1), KRT78(4), KRT79(2), KRT83(1), KRT84(1), KRT85(3), KRT9(1), LAMA1(3), LAMA2(4), LAMA3(7), LAMA4(4), LAMA5(2), LAMB1(7), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(4), LAMC2(1), LAMC3(1), LMNA(2), NES(3), RELN(4), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(3), TNXB(9), VWF(4)	153950717	195	135	194	64	82	27	7	41	38	0	0.104	1.000	1.000
518	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(1), COL11A2(5), COL1A1(3), COL1A2(3), COL3A1(2), COL4A1(2), COL4A2(3), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(2), COL5A3(3), COL6A1(2), COL6A3(7), COL6A6(2), DAG1(1), FN1(4), FNDC1(5), FNDC3A(1), GP5(3), GP9(1), HSPG2(9), ITGA1(1), ITGA10(2), ITGA11(2), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(3), ITGAV(3), ITGB4(2), ITGB5(1), ITGB6(4), ITGB8(1), LAMA1(3), LAMA2(4), LAMA3(7), LAMA4(4), LAMA5(2), LAMB1(7), LAMB2(2), LAMB3(1), LAMB4(2), LAMC1(4), LAMC2(1), LAMC3(1), RELN(4), SDC3(1), SV2A(3), SV2B(2), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(3), TNXB(9), VWF(4)	138236305	173	127	172	53	64	24	8	42	35	0	0.0875	1.000	1.000
519	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(1), ACVR2A(2), BMP7(3), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL11(1), CCL14(1), CCL17(1), CCL21(1), CCL28(1), CCL7(1), CCR1(1), CCR2(3), CCR4(1), CCR6(1), CCR7(2), CCR8(1), CCR9(1), CD27(1), CD40(1), CD40LG(1), CNTF(1), CSF1R(2), CSF2RA(3), CSF3R(1), CXCL16(1), CXCL9(1), CXCR6(1), EGF(2), EGFR(3), EPOR(1), FAS(1), FASLG(1), FLT1(3), FLT3(1), FLT3LG(1), FLT4(2), GH1(2), GH2(1), GHR(1), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(3), IL17RB(1), IL1A(1), IL1RAP(2), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL24(1), IL25(1), IL26(1), IL3RA(2), IL4(1), IL4R(3), IL6(1), IL6ST(6), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBC(2), INHBE(2), KDR(3), LEPR(1), LIFR(2), LTBR(2), MET(2), PDGFRA(2), PDGFRB(1), PF4(1), PRLR(1), TGFB1(1), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10D(1), TNFRSF11B(2), TNFRSF13B(2), TNFRSF18(2), TNFRSF21(4), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(2), TNFSF11(1), TNFSF12(1), TNFSF14(1), TNFSF15(1), TNFSF8(1), TPO(3), VEGFA(2), XCL1(1), XCR1(1)	111407361	165	116	165	45	46	19	21	51	28	0	0.0388	1.000	1.000
520	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(4), ABLIM1(2), CFL1(1), DCC(2), DPYSL2(1), DPYSL5(1), EFNA3(1), EFNA5(1), EFNB3(1), EPHA1(2), EPHA2(1), EPHA3(5), EPHA4(1), EPHA5(1), EPHA6(1), EPHA7(2), EPHA8(1), EPHB1(4), EPHB2(3), EPHB3(3), FES(3), GNAI1(1), GNAI2(1), GSK3B(1), L1CAM(6), LIMK1(2), LIMK2(3), LRRC4C(3), MAPK1(1), MET(2), NFATC1(1), NFATC2(2), NGEF(1), NRP1(1), NTN1(1), NTNG1(3), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(1), PLXNB1(2), PLXNB2(1), PLXNC1(3), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RAC3(1), RGS3(1), RHOD(1), ROBO1(6), ROBO2(5), ROBO3(1), ROCK1(5), SEMA3A(2), SEMA3C(2), SEMA3D(3), SEMA3E(2), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4C(2), SEMA4F(1), SEMA5A(1), SEMA5B(2), SEMA6A(1), SEMA6C(3), SEMA6D(2), SEMA7A(1), SLIT1(2), SLIT2(1), SLIT3(4), SRGAP1(4), SRGAP3(1), UNC5A(1), UNC5B(4), UNC5D(2)	123471354	157	113	156	51	57	13	17	51	19	0	0.329	1.000	1.000
521	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(5), ACACB(2), AKT1(3), AKT2(1), ARAF(1), CALML6(1), CBL(1), CRK(1), FASN(2), FLOT1(1), G6PC2(1), GCK(4), GRB2(1), GSK3B(1), GYS1(2), IKBKB(1), INPP5D(2), IRS1(2), IRS2(2), IRS4(3), MAPK1(1), PCK2(2), PDE3B(1), PDPK1(1), PFKL(2), PFKM(2), PFKP(2), PHKA1(1), PHKA2(1), PHKB(3), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PPARGC1A(3), PPP1CA(1), PPP1R3A(5), PPP1R3B(2), PRKAA2(4), PRKACA(2), PRKAG1(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(2), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(2), PYGL(2), RAF1(1), RAPGEF1(3), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOCS4(1), SORBS1(3), SOS1(1), TRIP10(1), TSC1(1), TSC2(4)	99371944	134	110	131	36	41	20	18	36	19	0	0.0440	1.000	1.000
522	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(1), ACTG1(2), AKT1(3), AKT2(1), ASH1L(7), CGN(2), CLDN10(1), CLDN15(1), CLDN20(1), CLDN23(2), CLDN9(2), CSNK2A2(1), CTNNA1(1), CTNNA2(4), CTNNA3(1), CTTN(1), EPB41L1(2), EPB41L2(3), EXOC4(2), GNAI1(1), GNAI2(1), IGSF5(1), INADL(4), JAM2(1), LLGL1(1), LLGL2(1), MAGI2(1), MAGI3(1), MLLT4(2), MPDZ(2), MRAS(1), MYH1(4), MYH10(6), MYH11(5), MYH13(5), MYH15(3), MYH2(2), MYH4(8), MYH6(6), MYH7(4), MYH7B(4), MYH8(5), MYH9(2), MYL5(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), RRAS2(1), SPTAN1(1), TJAP1(2), TJP1(1), TJP2(4), TJP3(3), VAPA(2)	119092075	140	109	139	41	49	16	10	38	27	0	0.118	1.000	1.000
523	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(2), ADORA2A(1), ADORA3(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(1), ADRB1(1), AGTR1(2), AVPR1A(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR1(1), CCR2(3), CCR4(1), CCR6(1), CCR7(2), CCR8(1), CCR9(1), CCRL2(1), CHRM2(2), CHRM4(1), CMKLR1(1), CNR1(3), CNR2(1), DRD2(1), DRD3(1), EDNRA(1), F2R(1), F2RL3(1), FPR1(2), FSHR(1), GALT(1), GPR17(2), GPR174(1), GPR35(1), GPR37(1), GPR37L1(3), GPR4(1), GPR50(4), GPR6(1), GPR83(2), GPR87(3), HCRTR2(4), HTR1A(3), HTR1D(1), HTR1E(4), HTR2A(2), HTR2B(2), HTR2C(2), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MTNR1A(1), MTNR1B(1), NMUR1(1), NMUR2(2), NPY1R(1), NPY2R(2), NPY5R(1), NTSR1(1), OPRL1(1), OPRM1(2), OR12D3(1), OR1Q1(1), OR7A5(2), P2RY1(1), P2RY10(1), P2RY14(1), P2RY6(1), PTGIR(2), RGR(1), SSTR1(2), SSTR2(1), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(1)	76526400	134	108	133	46	54	19	8	41	12	0	0.104	1.000	1.000
524	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(9), APC2(1), AXIN2(2), CACYBP(1), CAMK2A(1), CAMK2D(1), CCND3(1), CHD8(1), CREBBP(5), CSNK1A1L(1), CSNK1E(1), CSNK2A2(1), CTBP2(1), CXXC4(1), DAAM1(2), DAAM2(3), DKK1(2), DKK2(2), DVL2(2), DVL3(1), EP300(5), FBXW11(2), FZD1(2), FZD10(3), FZD2(4), FZD4(2), FZD5(2), FZD6(3), FZD7(1), FZD9(2), GSK3B(1), LEF1(2), LRP5(2), LRP6(1), MAP3K7(2), MYC(1), NFATC1(1), NFATC2(2), NKD2(1), NLK(1), PLCB1(3), PPARD(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE1(1), PRICKLE2(4), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), RAC3(1), ROCK1(5), SFRP2(2), SMAD2(2), SMAD3(1), SMAD4(5), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(3), VANGL2(2), WIF1(2), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1)	98927792	138	108	136	44	40	18	18	31	31	0	0.279	1.000	1.000
525	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ATF2(2), ATF4(1), ATP2A2(1), CAMK2A(1), CAMK2D(1), CORIN(3), CREB3(1), DGKZ(2), GJA1(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GNGT1(1), GRK4(1), GRK6(1), GSTO1(2), GUCY1A3(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(2), ITPR2(7), ITPR3(3), MAFF(1), MIB1(1), MYLK2(4), NOS1(3), NOS3(2), PDE4D(1), PLCG1(1), PLCG2(2), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), RAMP1(1), RAMP2(1), RGS11(1), RGS16(2), RGS3(1), RGS6(2), RGS9(2), RYR1(13), RYR2(14), RYR3(11), SLC8A1(3), SP1(2), TNXB(9), YWHAH(1), YWHAQ(1)	108701041	148	107	148	72	56	18	9	37	28	0	0.972	1.000	1.000
526	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(2), CADM3(3), CD226(1), CD276(1), CD34(1), CD40(1), CD40LG(1), CD8A(1), CD8B(2), CDH1(4), CDH2(2), CDH3(3), CDH4(5), CDH5(5), CLDN10(1), CLDN15(1), CLDN20(1), CLDN23(2), CLDN9(2), CNTN2(1), CNTNAP1(7), CNTNAP2(1), ESAM(1), GLG1(2), HLA-A(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HLA-G(1), ICAM2(1), ICAM3(1), ITGA4(2), ITGA6(2), ITGA8(2), ITGA9(3), ITGAL(3), ITGAM(2), ITGAV(3), ITGB2(2), ITGB8(1), JAM2(1), L1CAM(6), MADCAM1(1), MAG(1), NCAM1(1), NCAM2(3), NEGR1(1), NEO1(2), NFASC(1), NLGN1(1), NLGN3(1), NRCAM(3), NRXN1(3), NRXN2(2), NRXN3(3), PDCD1(1), PTPRC(7), PTPRF(2), PTPRM(1), PVRL1(2), PVRL2(2), SDC3(1), SELE(1), SELP(3), SELPLG(1), SIGLEC1(5), VCAM1(1), VCAN(3)	92676522	139	106	136	44	48	21	14	34	22	0	0.172	1.000	1.000
527	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(1), CBL(1), CCND3(1), CNTF(1), CREBBP(5), CSF2RA(3), CSF3R(1), EP300(5), EPOR(1), GH1(2), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL24(1), IL26(1), IL3RA(2), IL4(1), IL4R(3), IL6(1), IL6ST(6), IL7(1), IL7R(1), IL9(1), JAK1(3), JAK3(1), LEPR(1), LIFR(2), MYC(1), PIAS3(1), PIAS4(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PRLR(1), SOCS4(1), SOCS5(2), SOS1(1), SPRED2(2), SPRY3(1), STAT1(1), STAT2(1), STAT3(6), STAT4(4), STAT5B(1), STAT6(2), TPO(3), TYK2(1)	91640557	132	102	130	31	32	18	18	41	23	0	0.0300	1.000	1.000
528	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), AK5(1), AK7(1), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), APRT(1), ATIC(2), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD4(1), ENTPD6(3), FHIT(1), GART(1), GMPR(2), GMPR2(1), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), IMPDH2(2), NME1(1), NPR1(1), NT5C1B(1), NT5C2(2), NT5E(1), NT5M(1), PAPSS2(1), PDE10A(3), PDE1C(3), PDE2A(2), PDE3B(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE6D(1), PDE7A(2), PDE8A(3), PDE8B(1), PDE9A(2), POLA1(1), POLD1(1), POLD3(1), POLE(4), POLR1A(3), POLR1B(2), POLR1C(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3A(3), POLR3B(1), PPAT(1), PRIM2(1), PRPS1L1(3), RFC5(1)	102792895	116	100	115	42	41	17	12	30	16	0	0.451	1.000	1.000
529	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ADRB1(1), DRD2(1), EGF(2), EGFR(3), GJA1(1), GNAI1(1), GNAI2(1), GNAS(2), GRB2(1), GRM1(7), GRM5(3), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), HTR2A(2), HTR2B(2), HTR2C(2), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), NPR1(1), PDGFA(1), PDGFD(2), PDGFRA(2), PDGFRB(1), PLCB1(3), PRKACA(2), PRKCA(2), PRKCG(1), PRKG1(2), PRKX(2), RAF1(1), SOS1(1), TJP1(1), TUBA1A(1), TUBA3C(4), TUBA3E(1), TUBA4A(1), TUBB1(1), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(1)	81463928	103	83	102	38	41	11	4	32	15	0	0.536	1.000	1.000
530	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), AMY2B(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(4), DDX41(1), DDX47(3), DDX50(3), DDX56(1), ENPP1(2), ENPP3(1), ENTPD7(1), EP400(1), ERCC2(3), ERCC3(1), G6PC2(1), GAA(1), GANC(2), GBE1(2), GCK(4), GYS1(2), HK2(1), HK3(2), MGAM(6), MOV10L1(1), PGM1(1), PGM3(2), PYGL(2), RAD54B(3), RAD54L(1), RUVBL2(2), SETX(3), SI(5), SKIV2L2(3), SMARCA2(2), SMARCA5(3), TREH(1), UGDH(2), UGP2(1), UGT1A1(2), UGT1A4(1), UGT1A7(1), UGT1A9(1), UGT2A1(1), UGT2A3(2), UGT2B10(2), UGT2B11(2), UGT2B15(2), UGT2B17(1), UGT2B28(2), UGT2B7(2)	78045990	103	80	102	29	21	13	23	28	18	0	0.189	1.000	1.000
531	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(1), CD48(3), FAS(1), FASLG(1), GRB2(1), HLA-A(1), HLA-G(1), ICAM2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(2), LCP2(1), MAPK1(1), MICB(1), NCR1(1), NCR2(1), NFATC1(1), NFATC2(2), PAK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PLCG2(2), PPP3CA(1), PPP3CC(1), PRF1(1), PRKCA(2), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10D(1), VAV1(3), VAV2(2), VAV3(3), ZAP70(3)	70122760	101	77	100	34	34	13	12	28	14	0	0.396	1.000	1.000
532	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), AK5(1), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), APRT(1), ATIC(2), ATP5A1(2), ATP5G3(1), ATP5J(1), CANT1(2), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(3), GUCY1A3(1), GUCY2C(3), GUCY2F(3), IMPDH2(2), NME1(1), NPR1(1), NT5E(1), NT5M(1), PAPSS2(1), PDE4A(2), PDE4C(1), PDE4D(1), PDE6B(1), PDE6C(1), PDE8A(3), PDE9A(2), POLD1(1), POLE(4), POLG(1), POLL(1), POLQ(5), POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1), PPAT(1), PRPS1L1(3)	80761676	89	77	88	36	27	13	14	22	13	0	0.716	1.000	1.000
533	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), ATF4(1), CACNA1C(2), CACNA1D(4), CACNA1F(2), CACNA1S(4), CALML6(1), CAMK2A(1), CAMK2D(1), CGA(1), EGFR(3), GNAS(2), GNRHR(3), GRB2(1), ITPR1(2), ITPR2(7), ITPR3(3), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K3(1), MAP3K4(1), MAPK1(1), MAPK12(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(3), PLA2G6(1), PLCB1(3), PLD1(3), PLD2(1), PRKACA(2), PRKCA(2), PRKX(2), RAF1(1), SOS1(1)	77692610	88	74	88	37	28	12	4	28	16	0	0.851	1.000	1.000
534	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), CALML6(1), CAMK2A(1), CAMK2D(1), CREB3(1), CREB3L2(2), CREB3L3(1), CREB3L4(1), CREBBP(5), DVL2(2), DVL3(1), EP300(5), FZD1(2), FZD10(3), FZD2(4), FZD4(2), FZD5(2), FZD6(3), FZD7(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(2), GSK3B(1), LEF1(2), MAPK1(1), PLCB1(3), POMC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7L1(1), TCF7L2(3), TYR(2), TYRP1(1), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1)	65769628	91	73	91	43	34	16	8	19	14	0	0.783	1.000	1.000
535	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	62	ADCY1(2), ADCY8(5), ARAF(1), ATF4(1), CACNA1C(2), CALML6(1), CAMK2A(1), CAMK2D(1), CAMK4(2), CREBBP(5), EP300(5), GRIA2(4), GRIN1(2), GRIN2B(6), GRIN2C(1), GRM1(7), GRM5(3), ITPR1(2), ITPR2(7), ITPR3(3), MAPK1(1), PLCB1(3), PPP1CA(1), PPP1R1A(1), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(1), RPS6KA6(1)	56511941	81	69	80	27	29	8	5	24	15	0	0.504	1.000	1.000
536	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(2), ADCY2(2), ADCY3(1), ADCY4(2), ADCY6(2), ADCY8(5), ADCY9(3), AKAP1(2), AKAP11(2), AKAP12(5), AKAP3(2), AKAP4(1), AKAP6(2), AKAP8(1), AKAP9(5), ARHGEF1(4), GNA13(1), GNAI2(1), GNAL(1), GNAO1(1), GNAZ(3), GNB1(1), GNB3(1), GNB5(1), GNGT1(1), ITPR1(2), PDE1B(1), PDE1C(3), PDE4A(2), PDE4C(1), PDE4D(1), PDE7A(2), PDE8A(3), PDE8B(1), PPP3CA(1), PPP3CC(1), PRKACA(2), PRKAR1A(1), PRKAR1B(2), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), PRKCZ(2), PRKD1(2), PRKD3(1), SLC9A1(1)	73421508	86	67	86	34	29	11	7	27	12	0	0.660	1.000	1.000
537	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(1), ABCA12(4), ABCA13(9), ABCA3(1), ABCA4(3), ABCA5(5), ABCA7(2), ABCA8(1), ABCA9(5), ABCB1(4), ABCB11(1), ABCB4(1), ABCB5(2), ABCB6(1), ABCB7(1), ABCB9(1), ABCC10(2), ABCC11(4), ABCC12(2), ABCC3(2), ABCC4(3), ABCC5(3), ABCC6(1), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(2), ABCG2(2), ABCG4(1), CFTR(1), TAP1(2), TAP2(1)	74223250	79	66	79	38	22	15	12	15	15	0	0.848	1.000	1.000
538	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(1), CD14(1), CD40(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IKBKB(1), IKBKE(1), IL12A(1), IL12B(1), IL6(1), IRAK1(1), IRAK4(1), IRF3(2), LY96(1), MAP2K4(3), MAP2K7(3), MAP3K7(2), MAP3K8(1), MAPK1(1), MAPK12(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), RAC1(1), RELA(2), RIPK1(1), STAT1(1), TBK1(1), TLR4(1), TLR5(2), TLR7(1), TLR8(2), TLR9(1), TNF(1)	56565535	78	66	76	25	21	12	11	20	14	0	0.345	1.000	1.000
539	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(1), CARD11(2), CBL(1), CD40LG(1), CD8A(1), CD8B(2), GRB2(1), IKBKB(1), IL10(1), IL4(1), ITK(1), LCP2(1), MAP3K8(1), NFATC1(1), NFATC2(2), NFKBIB(1), NFKBIE(1), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(1), PTPRC(7), SOS1(1), TNF(1), VAV1(3), VAV2(2), VAV3(3), ZAP70(3)	63725721	83	66	81	25	27	12	9	26	9	0	0.232	1.000	1.000
540	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(2), BDKRB2(1), C1S(2), C3(2), C3AR1(1), C4BPA(1), C6(4), C8B(1), C9(2), CD46(2), CFB(2), CFH(7), CFI(1), CPB2(1), CR1(1), F10(2), F11(4), F12(1), F13A1(2), F13B(2), F2(1), F2R(1), F3(1), F5(4), F7(2), F8(1), FGA(5), FGB(2), KLKB1(1), MASP1(3), MASP2(1), PLAT(2), PLAU(2), PLG(1), PROC(2), PROS1(2), SERPIND1(2), SERPINF2(1), SERPING1(1), VWF(4)	56930433	82	65	81	31	24	8	9	28	13	0	0.771	1.000	1.000
541	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG12(1), ALG14(2), B3GNT7(1), B4GALT1(2), B4GALT2(2), B4GALT5(1), CHPF(1), CHST1(1), CHST11(3), CHST12(1), CHST3(1), CHST4(1), CHSY1(1), EXT1(3), EXT2(3), EXTL1(2), EXTL3(2), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT3(2), GALNT4(2), GALNT8(2), GALNTL5(3), GANAB(1), GCNT1(1), HS3ST3A1(1), HS6ST1(2), HS6ST2(1), MAN1A1(2), MAN1C1(1), MAN2A1(3), MGAT5(1), MGAT5B(2), NDST1(2), NDST3(2), NDST4(5), OGT(1), RPN1(1), ST3GAL1(2), ST6GAL1(1), UST(1), WBSCR17(1), XYLT1(5), XYLT2(1)	69048835	83	64	83	25	30	10	8	20	15	0	0.297	1.000	1.000
542	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	61	AKT1(3), AKT2(1), BTK(1), CARD11(2), CD79A(1), CD81(2), GSK3B(1), IKBKB(1), INPP5D(2), NFATC1(1), NFATC2(2), NFKBIB(1), NFKBIE(1), PIK3CA(12), PIK3CB(3), PIK3CD(4), PIK3CG(4), PIK3R1(1), PIK3R2(3), PIK3R3(2), PLCG2(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV1(3), VAV2(2), VAV3(3)	46614202	65	58	63	22	19	9	8	19	10	0	0.409	1.000	1.000
543	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(1), CD14(1), CD1B(2), CD1C(3), CD1E(2), CD34(1), CD37(1), CD38(1), CD8A(1), CD8B(2), CR1(1), CSF1R(2), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(1), FLT3LG(1), GP5(3), GP9(1), HLA-DRA(1), IL11RA(1), IL1A(1), IL3RA(2), IL4(1), IL4R(3), IL6(1), IL7(1), IL7R(1), ITGA1(1), ITGA2(3), ITGA2B(4), ITGA3(2), ITGA4(2), ITGA6(2), ITGAM(2), MME(2), TNF(1), TPO(3)	51292985	65	57	65	28	18	8	4	25	10	0	0.780	1.000	1.000
544	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(2), DAXX(1), GRB2(1), IKBKB(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K10(4), MAP3K11(2), MAP3K12(1), MAP3K13(2), MAP3K3(1), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAP3K8(1), MAP3K9(2), MAP4K1(1), MAPK1(1), MAPK12(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), MYC(1), PAK1(1), PAK2(1), RAC1(1), RAF1(1), RELA(2), RIPK1(1), RPS6KA1(1), RPS6KA4(2), RPS6KA5(3), RPS6KB2(1), SHC1(2), SP1(2), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRAF2(4)	58464321	67	56	67	23	21	8	11	15	12	0	0.550	1.000	1.000
545	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK2(1), CLK3(2), CPSF2(1), CSTF2T(1), CSTF3(1), DDX1(1), DHX15(1), DHX16(1), DHX38(1), DHX8(1), DHX9(1), DICER1(2), METTL3(2), NONO(1), NXF1(1), PHF5A(1), POLR2A(3), PPM1G(2), PRPF3(2), PRPF4(1), PRPF4B(1), PRPF8(3), PTBP1(3), RBM17(1), RBM5(2), RNGTT(1), RNMT(2), SF3A1(3), SF3A2(1), SF3A3(1), SF3B1(4), SF3B5(1), SNRPA1(1), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPG(1), SNRPN(2), SRRM1(1), SUPT5H(1)	65963414	60	51	60	16	14	8	15	11	12	0	0.308	1.000	1.000
546	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(2), ADCY8(5), CACNA1A(10), CACNA1B(1), GNAS(2), GNB1(1), GNB3(1), GRM4(1), ITPR3(3), KCNB1(4), PRKACA(2), PRKX(2), SCNN1B(4), SCNN1G(1), TAS1R2(3), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TRPM5(3)	35763638	55	48	55	23	25	3	5	14	8	0	0.731	1.000	1.000
547	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(7), CTCFL(1), DOT1L(3), EED(1), EHMT2(1), EZH1(1), EZH2(1), HCFC1(1), JMJD4(1), MEN1(2), NSD1(2), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(2), PRDM9(3), PRMT1(1), PRMT5(2), PRMT8(1), RBBP5(2), SETD1A(2), SETD2(4), SETDB1(2), SETDB2(1), SUV420H1(1), SUV420H2(1), WHSC1(1), WHSC1L1(3)	73023770	51	46	51	15	14	6	3	13	15	0	0.548	1.000	1.000
548	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), ACAT1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AOC2(1), AOX1(2), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(1), EHHADH(5), HADH(1), HEMK1(1), HSD17B4(3), KMO(1), KYNU(3), LCMT2(1), LNX1(1), MAOA(2), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), PRMT8(1), TDO2(1), TPH1(1), TPH2(2), WARS(1)	38087169	46	44	46	22	8	6	6	14	11	1	0.938	1.000	1.000
549	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(1), BCR(1), BTK(1), DAG1(1), EPHB2(3), GRB2(1), ITPKB(2), MAPK1(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CA(12), PIK3CD(4), PIK3R1(1), PLCG2(2), PPP1R13B(1), RAF1(1), SHC1(2), SOS1(1), SYK(2), VAV1(3)	33239256	46	43	44	17	15	8	5	11	7	0	0.590	1.000	1.000
550	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BTK(1), CAD(2), DAXX(1), DEDD2(1), DFFA(1), EGFR(3), EPHB2(3), FAF1(4), IL1A(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K5(1), MAPK1(1), MAPK8IP3(3), MET(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PFN1(1), PFN2(2), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TPX2(1), TRAF2(4)	45258364	51	42	50	17	16	4	6	14	11	0	0.542	1.000	1.000
551	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(1), BMP5(3), BMP6(1), BMP7(3), BMP8B(1), CSNK1A1L(1), CSNK1E(1), CSNK1G1(2), CSNK1G3(1), FBXW11(2), GLI1(4), GLI2(3), GLI3(2), GSK3B(1), HHIP(4), LRP2(2), PRKACA(2), PRKX(2), PTCH1(1), PTCH2(4), SHH(2), STK36(3), SUFU(1), WNT2(1), WNT5A(1), WNT6(2), WNT9A(1)	38350769	52	41	52	22	19	10	7	9	7	0	0.522	1.000	1.000
552	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(6), B3GALT4(2), CDR1(1), DGKI(5), IL6ST(6), RPL10(1), RPL12(1), RPL19(2), RPL28(1), RPL3(1), RPL37(1), RPL3L(1), RPL5(2), RPL7(1), RPL8(1), RPS11(2), RPS27A(2), RPS6KA1(1), RPS6KA6(1), RPS6KB2(1), RPS9(2), SLC36A2(1), UBB(1), UBC(1)	32815063	44	41	44	28	11	8	2	13	10	0	0.999	1.000	1.000
553	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(2), ALPPL2(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(4), DDX41(1), DDX47(3), DDX50(3), DDX56(1), DHFR(1), ENTPD7(1), EP400(1), ERCC2(3), ERCC3(1), MOV10L1(1), RAD54B(3), RAD54L(1), RUVBL2(2), SETX(3), SKIV2L2(3), SMARCA2(2), SMARCA5(3), SPR(1)	39612926	46	40	46	17	11	9	9	11	6	0	0.554	1.000	1.000
554	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(1), EGFR(3), ERBB2(3), ERBB4(2), ETS1(1), ETV6(1), FMN2(4), GRB2(1), MAPK1(1), NOTCH1(3), NOTCH2(4), NOTCH3(3), NOTCH4(3), PIWIL1(7), PIWIL2(2), PIWIL3(2), RAF1(1), SOS1(1)	31920891	43	39	43	16	13	6	6	10	8	0	0.659	1.000	1.000
555	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AKT1(3), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(2), CREBBP(5), F2(1), GSK3B(1), MAPK1(1), MEF2C(2), MYH2(2), NFATC1(1), NFATC2(2), NPPA(1), PIK3CA(12), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), RAF1(1), SYT1(1)	31794083	46	39	44	18	16	6	6	15	3	0	0.632	1.000	1.000
556	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), BDKRB2(1), CAV1(1), CHRNA1(1), FLT1(3), FLT4(2), KDR(3), NOS3(2), PDE2A(2), PDE3B(1), PRKAR1A(1), PRKAR1B(2), PRKG1(2), RYR2(14), SYT1(1), TNNI1(1)	25356438	41	39	40	21	19	6	1	8	7	0	0.816	1.000	1.000
557	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTR3(1), AKT1(3), CFL1(1), FLNA(1), FLNC(3), FSCN2(1), FSCN3(3), LIMK1(2), MYH2(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PFN1(1), PFN2(2), ROCK1(5), WASF1(1)	30085994	41	39	39	21	11	7	4	15	4	0	0.927	1.000	1.000
558	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CCNH(1), CDC25A(1), CDK7(1), CDKN1A(2), CDKN2A(1), CREB3(1), CREB3L3(1), CREB3L4(1), E2F3(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), MDM2(1), MYC(1), MYT1(1), NACA(1), PCNA(1), POLE(4), RB1(2), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(9)	43938976	46	37	46	20	15	4	7	10	9	1	0.790	1.000	1.000
559	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CFL1(1), LIMK1(2), MAP3K1(1), MYLK(4), NCF2(3), PAK1(1), PDGFRA(2), PIK3CA(12), PIK3R1(1), PLD1(3), RAC1(1), RALBP1(1), TRIO(5), VAV1(3), WASF1(1)	22007397	41	37	40	15	13	5	5	13	5	0	0.700	1.000	1.000
560	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), DAXX(1), GRB2(1), HMGN1(1), MAP2K4(3), MAP3K1(1), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPKAPK5(1), MEF2A(1), MEF2C(2), MEF2D(1), MYC(1), PLA2G4A(3), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(2), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRAF2(4)	22708333	40	36	40	15	14	1	7	14	4	0	0.702	1.000	1.000
561	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A2(3), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH4A1(1), AMD1(1), AOC2(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(3), DAO(1), GOT1(1), GOT2(1), MAOA(2), NOS1(3), NOS3(2), P4HA1(3), P4HA2(1), P4HA3(2), PYCR1(1)	27749972	37	35	36	20	10	5	4	13	5	0	0.963	1.000	1.000
562	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(2), F11(4), F12(1), F13B(2), F2(1), F5(4), F7(2), F8(1), FGA(5), FGB(2), LPA(2), PLAT(2), PLAU(2), PLG(1), SERPINB2(1), SERPINF2(1), VWF(4)	22197104	37	34	37	17	11	6	4	11	5	0	0.851	1.000	1.000
563	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6V0A2(3), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(3), IGSF5(1), IKBKB(1), JAM2(1), MAP2K4(3), MAPK12(1), MET(2), NOD1(3), PAK1(1), PLCG1(1), PLCG2(2), RAC1(1), RELA(2), TJP1(1)	43666102	36	33	36	13	6	7	5	12	6	0	0.637	1.000	1.000
564	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), DAG1(1), EPHB2(3), GRB2(1), ITK(1), ITPKB(2), LCP2(1), MAPK1(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(1), PAK2(1), PAK6(1), PAK7(2), PLCG1(1), PTPRC(7), RAF1(1), SOS1(1), VAV1(3), ZAP70(3)	35164135	35	33	35	15	15	5	3	9	3	0	0.807	1.000	1.000
565	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(1), ARHGDIB(1), BIRC2(1), CFLAR(1), DAXX(1), DFFA(1), GSN(1), LMNA(2), MAP2K7(3), MAP3K1(1), MAP3K5(1), MDM2(1), NUMA1(2), PAK2(1), PRKDC(7), PTK2(2), RB1(2), RELA(2), RIPK1(1), SPTAN1(1), TNF(1), TRAF1(1), TRAF2(4)	43457103	41	32	41	13	14	10	4	7	5	1	0.398	1.000	1.000
566	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(3), DAO(1), EPRS(3), GLUD2(2), GOT1(1), GOT2(1), NOS1(3), NOS3(2), P4HA1(3), P4HA2(1), P4HA3(2), PARS2(2), PYCR1(1)	22573197	31	31	31	16	10	6	3	9	3	0	0.876	1.000	1.000
567	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	DAXX(1), EGF(2), EGFR(3), ETS1(1), IKBKB(1), MAP2K4(3), MAP2K7(3), MAP3K1(1), MAP3K5(1), MAPK1(1), PPP2CA(1), PRKCA(2), PRKCG(1), PRKCH(1), PRKCQ(1), RAF1(1), RELA(2), RIPK1(1), SP1(2), TNF(1), TRAF2(4)	30628263	34	31	34	16	10	4	5	11	4	0	0.862	1.000	1.000
568	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(1), GRB2(1), IARS(1), IL13RA1(1), IL4(1), IL4R(3), INPP5D(2), JAK1(3), JAK3(1), PIK3CA(12), PPP1R13B(1), SHC1(2), SOS1(1), STAT6(2), TYK2(1)	23244626	36	31	34	13	9	7	4	11	5	0	0.598	1.000	1.000
569	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), CBL(1), CFLAR(1), GRB2(1), IRS1(2), JAK1(3), JAK3(1), MAPK1(1), MYC(1), PIK3CA(12), PIK3R1(1), RAF1(1), SHC1(2), SOS1(1), STAT5B(1), SYK(2)	22451303	34	30	32	13	9	9	3	11	2	0	0.644	1.000	1.000
570	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), ALDH5A1(1), CAD(2), CPS1(3), EPRS(3), GAD1(2), GAD2(6), GFPT2(2), GLUD2(2), GLUL(1), GNPNAT1(1), GOT1(1), GOT2(1), NADSYN1(1), NAGK(1), PPAT(1), QARS(1)	24905783	30	28	30	16	10	4	3	6	7	0	0.915	1.000	1.000
571	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(5), ACACB(2), ACAT1(1), ACOT12(2), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), LDHAL6A(1), LDHC(1), ME1(2), ME3(1), PC(1), PCK2(2), PDHA2(3)	29456254	28	28	28	11	7	4	4	9	4	0	0.620	1.000	1.000
572	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AMDHD1(2), AOC2(1), ASPA(1), CNDP1(2), HAL(1), HDC(1), HEMK1(1), LCMT2(1), MAOA(2), METTL6(1), PRMT3(2), PRMT5(2), PRMT8(1), UROC1(3)	24882638	28	27	28	14	6	3	4	8	7	0	0.936	1.000	1.000
573	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(1), MCM10(1), MCM2(1), MCM3(1), MCM4(2), MCM5(1), MCM6(2), MCM7(1), NACA(1), PCNA(1), POLD1(1), POLD3(1), POLE(4), RFC1(1), RFC3(1), RFC5(1), RPA1(1), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1)	31904727	32	26	32	21	9	5	5	6	7	0	0.977	1.000	1.000
574	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(5), EP300(5), IL7(1), IL7R(1), JAK1(3), JAK3(1), PIK3CA(12), PIK3R1(1), STAT5B(1)	17566558	30	26	29	11	8	5	4	11	2	0	0.709	1.000	1.000
575	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CREBBP(5), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(2), PTPRC(7), ZAP70(3)	14485357	25	24	25	13	9	2	3	10	1	0	0.903	1.000	1.000
576	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CREBBP(5), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(1), PRKAR1B(2), PTPRC(7), ZAP70(3)	14485357	25	24	25	13	9	2	3	10	1	0	0.903	1.000	1.000
577	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), ACY3(1), AGXT(1), ASPA(1), CAD(2), DARS2(1), DDO(1), GAD1(2), GAD2(6), GOT1(1), GOT2(1), NARS2(1), PC(1), PDHA2(3)	23822084	24	24	24	10	8	4	2	3	7	0	0.721	1.000	1.000
578	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), ALAS2(1), AMT(1), AOC2(1), CBS(1), CHDH(2), CTH(1), DAO(1), GARS(1), GCAT(1), GLDC(2), MAOA(2), PISD(1), RDH12(1), SARDH(3), SARS(1), SHMT1(1), SHMT2(1), TARS(1), TARS2(2)	26751863	26	24	26	10	8	3	0	7	8	0	0.889	1.000	1.000
579	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	40	ACTG1(2), ADCY3(1), ADCY9(3), ATP6V0A2(3), ATP6V0D2(1), ATP6V1A(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(2), PRKCA(2), SEC61A1(1), SEC61A2(1)	22712582	24	24	24	10	5	4	2	9	4	0	0.674	1.000	1.000
580	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	CAMK2A(1), CAMK2D(1), F2(1), GNAI1(1), GNB1(1), GNGT1(1), GRB2(1), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(2), RAF1(1), SHC1(2), SOS1(1), STAT1(1), STAT3(6), SYT1(1)	25957022	27	23	27	15	10	3	4	9	1	0	0.928	1.000	1.000
581	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), ALDH5A1(1), CAD(2), CPS1(3), EPRS(3), GAD1(2), GAD2(6), GLUL(1), GOT1(1), GOT2(1), NADSYN1(1), PPAT(1), QARS(1)	20939612	24	23	24	14	8	3	3	5	5	0	0.936	1.000	1.000
582	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(5), ACACB(2), ACAT1(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), EHHADH(5), LDHAL6A(1), LDHC(1), MUT(1)	25014822	23	23	23	11	7	3	3	8	2	0	0.876	1.000	1.000
583	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA1(1), CA12(1), CA14(2), CA2(2), CA3(1), CA4(1), CA5A(1), CA6(1), CA8(3), CA9(2), CPS1(3), CTH(1), GLUD2(2), GLUL(1), HAL(1)	13389549	24	23	24	10	7	5	1	7	4	0	0.678	1.000	1.000
584	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(1), CAPNS1(1), EGF(2), EGFR(3), ITGA1(1), MAPK1(1), MYLK(4), PRKAR1A(1), PRKAR1B(2), PTK2(2), PXN(2), TLN1(2)	20253332	22	21	22	10	5	2	1	12	2	0	0.843	1.000	1.000
585	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(1), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT3(2), GALNT4(2), GALNT8(2), GALNTL5(3), GCNT1(1), OGT(1), ST3GAL1(2), WBSCR17(1)	20345131	23	20	23	12	9	2	1	7	4	0	0.934	1.000	1.000
586	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	DLG4(1), GRIN1(2), GRIN2B(6), GRIN2C(1), NOS1(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2), SYT1(1)	14193194	21	20	21	10	7	4	0	9	1	0	0.762	1.000	1.000
587	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CREB3(1), DUSP1(1), EEF2K(4), EIF4E(1), MAP2K4(3), MAP3K10(4), MAP3K4(1), MAP3K5(1), MAP3K7(2), MAPK1(1), MAPK12(1), MAPKAPK5(1)	20926495	24	20	23	10	9	3	2	5	5	0	0.782	1.000	1.000
588	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), APOA4(1), APOE(1), CETP(1), CYP7A1(1), DGAT1(1), LDLR(1), LPL(1), LRP1(5), SCARB1(2), SOAT1(1)	17271285	22	20	22	10	7	5	2	4	4	0	0.702	1.000	1.000
589	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C6(4), IL1A(1), IL6(1), ITGA4(2), ITGAL(3), ITGB2(2), SELP(3), SELPLG(1), TNF(1), VCAM1(1)	15634663	21	19	21	10	8	3	3	6	1	0	0.722	1.000	1.000
590	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), CDK7(1), ERCC3(1), GTF2E2(1), POLR1A(3), POLR1B(2), POLR2A(3), POLR2B(2), POLR2E(1), POLR3B(1), TAF13(1), TAF5(1), TAF6(1)	22068381	19	19	19	17	5	1	3	9	1	0	0.998	1.000	1.000
591	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(1), F2R(1), FGA(5), FGB(2), PLAT(2), PLAU(2), PLG(1), SERPINB2(1)	8446818	18	17	18	10	7	0	2	8	1	0	0.938	1.000	1.000
592	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(1), ALDH2(1), ALDH3A1(1), AMD1(1), AOC2(1), ARG2(1), CPS1(3), MAOA(2), NAGS(1)	18470328	16	16	16	11	4	1	2	6	3	0	0.981	1.000	1.000
593	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E2(1), GTF2H3(1), STON1(1), TAF1(1), TAF13(1), TAF1L(7), TAF2(1), TAF5(1), TAF5L(1), TAF6(1), TAF7L(2)	22698794	18	15	18	10	5	4	4	3	2	0	0.912	1.000	1.000
594	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), HDAC3(2), NCOA1(2), NCOA2(1), NCOA3(1), NCOR2(4), POLR2A(3)	15658840	14	14	14	17	5	2	1	3	3	0	0.999	1.000	1.000
595	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(5), EP300(5), NCOA3(1), PRKAR1A(1), PRKAR1B(2)	13052115	14	13	14	10	6	0	3	4	1	0	0.949	1.000	1.000
596	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	IKBKB(1), MAP2K4(3), MAP3K1(1), RELA(2), RIPK1(1), TANK(1), TNF(1), TRAF2(4)	15100007	14	13	14	7	6	1	3	4	0	0	0.757	1.000	1.000
597	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	HLA-DRA(1), PTPRC(7), ZAP70(3)	5712127	11	11	11	5	5	2	2	2	0	0	0.616	1.000	1.000
598	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(3), ITGB2(2), PTPRC(7)	7112925	12	11	12	7	5	1	2	4	0	0	0.825	1.000	1.000
599	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), GNAS(2), PLCE1(2), PRKAR1A(1), PRKAR1B(2), RAP2B(1)	9298231	10	10	10	7	3	0	0	7	0	0	0.980	1.000	1.000
600	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PRKACA(2), PRKAR1A(1)	4143561	9	9	9	5	2	0	0	7	0	0	0.964	1.000	1.000
601	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), TGFB1(1), TGFB2(2), TNF(1), TNFRSF8(2), TNFSF8(1)	8210874	10	9	10	6	4	1	3	2	0	0	0.836	1.000	1.000
602	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(1), PRKAR1B(2), PRKCA(2)	6037308	9	8	9	5	2	0	0	7	0	0	0.938	1.000	1.000
603	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), CFTR(1), GNAS(2), PRKAR1A(1), PRKAR1B(2)	8214859	8	8	8	7	2	1	0	5	0	0	0.989	1.000	1.000
604	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), MPI(1), PGM1(1), PYGL(2), TREH(1)	8426029	8	8	8	5	4	2	1	1	0	0	0.827	1.000	1.000
605	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), B4GALT1(2), B4GALT2(2), CHST1(1), CHST4(1), ST3GAL1(2)	7856869	9	7	9	5	7	1	0	1	0	0	0.831	1.000	1.000
606	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	IL4(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR3(1)	6677406	7	7	7	5	1	1	3	2	0	0	0.906	1.000	1.000
607	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), GOT2(1), TYR(2)	2956996	4	4	4	3	2	1	0	1	0	0	0.878	1.000	1.000
608	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), EIF4E(1), LDHC(1)	5643118	3	3	3	3	1	1	0	1	0	0	0.930	1.000	1.000
609	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1)	3439142	2	2	2	3	1	1	0	0	0	0	0.960	1.000	1.000
610	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOC(2)	2465689	2	2	2	2	0	0	1	1	0	0	0.943	1.000	1.000
611	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	455860	1	1	1	2	1	0	0	0	0	0	0.977	1.000	1.000
612	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	SQLE(1)	2672374	1	1	1	2	1	0	0	0	0	0	0.958	1.000	1.000
613	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		1037992	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		1082786	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		2029642	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		719836	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
