rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(9), NRG2(2), NRG3(4), PRKCA(3), PSEN1(1)	1586122	21	16	21	3	6	7	2	3	3	0	0.115	0.0302	1.000
2	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	129236	4	3	4	0	3	1	0	0	0	0	0.274	0.0665	1.000
3	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(2), APAF1(4), CASP3(1), CASP9(1), DAXX(4), FAS(2), HSPB2(1), MAPKAPK2(1), TNF(1)	1838947	17	14	16	1	1	3	0	11	2	0	0.119	0.0668	1.000
4	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(3), HSD3B1(1), HSD3B2(1)	1477777	14	13	13	3	3	5	0	2	4	0	0.453	0.0869	1.000
5	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(3), HSD3B1(1), HSD3B2(1)	1477777	14	13	13	3	3	5	0	2	4	0	0.453	0.0869	1.000
6	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(4), GNGT1(1), PRKACA(1), PRKAR1A(5)	974544	16	14	16	3	5	4	2	3	2	0	0.245	0.0915	1.000
7	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(2), AXIN1(2), BTRC(4), CTNNB1(21), DLL1(4), FZD1(2), GSK3B(1), NOTCH1(1), PSEN1(1)	1902790	38	29	36	9	7	10	1	16	4	0	0.298	0.0959	1.000
8	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1)	660538	9	7	9	1	5	2	0	0	2	0	0.253	0.102	1.000
9	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(3)	352237	4	4	4	1	0	3	0	1	0	0	0.665	0.157	1.000
10	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), SNAP25(1), STX1A(1)	555266	5	5	5	1	0	3	0	2	0	0	0.569	0.161	1.000
11	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(4), GNGT1(1), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2508498	30	21	30	6	14	6	2	6	2	0	0.126	0.162	1.000
12	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(2), HLA-DRA(1), HLA-DRB1(1)	435215	5	4	6	2	2	0	0	1	2	0	0.875	0.165	1.000
13	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), GRIA2(6)	560749	7	6	7	2	2	3	0	2	0	0	0.491	0.175	1.000
14	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(1)	395820	3	3	3	1	1	0	0	2	0	0	0.695	0.191	1.000
15	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(4), ARHGAP5(8), CASP3(1), CASP8(1), CASP9(1), GZMB(1), PRF1(1)	2208499	17	14	13	2	0	2	1	9	5	0	0.306	0.193	1.000
16	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(4), GNGT1(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3)	1549522	18	14	18	3	7	4	2	3	2	0	0.161	0.209	1.000
17	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(1)	211832	2	2	2	0	0	0	0	1	1	0	0.788	0.222	1.000
18	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(3), ADORA3(1), LTB4R(1), P2RY1(3), P2RY2(2), P2RY6(1)	865591	15	9	15	2	7	6	0	2	0	0	0.0579	0.223	1.000
19	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2162414	16	13	16	3	8	3	0	2	3	0	0.197	0.263	1.000
20	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GPX1(1), PRKCE(2)	1274748	19	9	20	2	6	8	1	3	1	0	0.0471	0.266	1.000
21	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(1), GAD1(2), HDC(6), TPH1(2)	871833	11	8	11	2	3	6	0	1	1	0	0.286	0.283	1.000
22	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(3), MAP2K1(2), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(3)	1238125	12	8	12	3	6	1	0	4	1	0	0.406	0.289	1.000
23	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(1), CD3G(1), GZMB(1), HLA-A(3), ITGAL(3), ITGB2(2), PRF1(1)	1350876	14	10	14	4	2	2	1	4	4	1	0.549	0.293	1.000
24	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GPHN(2)	2093736	21	11	22	1	7	9	0	4	1	0	0.0165	0.298	1.000
25	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(6), ATM(37), BAX(2), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(6)	3255706	58	30	56	12	9	19	3	19	6	2	0.212	0.319	1.000
26	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3G(1), CREBBP(13), CSK(2), GNAS(4), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PTPRC(9)	3670052	49	26	48	9	15	11	4	11	8	0	0.0645	0.339	1.000
27	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3G(1), CREBBP(13), CSK(2), GNAS(4), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PTPRC(9)	3670052	49	26	48	9	15	11	4	11	8	0	0.0645	0.339	1.000
28	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(4), BAX(2), BCL2L11(1), CASP8AP2(3), CASP9(1), CES1(1)	1677948	12	13	15	2	1	6	0	2	3	0	0.533	0.357	1.000
29	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), NFS1(1), TPK1(5)	1112829	11	8	11	2	4	5	0	2	0	0	0.408	0.384	1.000
30	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK2(1), HK3(5), IMPA2(1), PGM1(2), PGM3(2), TGDS(1)	1884988	15	13	15	2	10	3	0	1	1	0	0.0784	0.411	1.000
31	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK2(1), HK3(5), PGM1(2), PGM3(2), TGDS(1)	1721912	14	12	14	2	9	3	0	1	1	0	0.109	0.420	1.000
32	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(1)	522952	3	3	3	1	1	2	0	0	0	0	0.706	0.454	1.000
33	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(13), DFFA(2), GZMA(3), GZMB(1), PRF1(1)	1745786	22	13	20	5	5	4	3	7	3	0	0.301	0.458	1.000
34	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(2), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(2)	870462	10	6	11	4	5	2	0	1	2	0	0.791	0.464	1.000
35	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), DLL1(4), FURIN(3), NOTCH1(1), PSEN1(1)	1033414	11	8	11	3	5	0	1	1	4	0	0.449	0.466	1.000
36	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2), SHMT1(1)	576879	3	3	3	1	0	1	0	0	2	0	0.909	0.466	1.000
37	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(4), BAX(2), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), DFFA(2)	2329837	21	11	19	1	3	9	0	3	6	0	0.0654	0.483	1.000
38	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1), HLA-DRB1(1)	334065	3	2	4	0	2	0	0	0	1	0	0.466	0.493	1.000
39	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), GRB2(2), IL2(1), IL2RA(3), IL2RB(1), IL2RG(1), JAK1(2), JAK3(4), LCK(1), MAP2K1(2), MAPK3(1), MAPK8(6), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(3)	3921740	40	21	40	5	8	11	1	12	7	1	0.0452	0.519	1.000
40	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(4), ACTN2(4), BCAR1(1), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), VCL(1)	3009756	40	33	38	9	9	13	0	17	1	0	0.265	0.521	1.000
41	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(3), DNMT1(8), MTNR1A(1), MTNR1B(4), PTGDR(2), PTGFR(1)	1710085	19	15	19	4	12	4	1	2	0	0	0.118	0.529	1.000
42	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), GNAS(4), PLCE1(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RAP2B(1)	2354815	22	15	22	4	8	6	2	4	2	0	0.146	0.548	1.000
43	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2660046	17	12	17	2	3	7	0	7	0	0	0.130	0.550	1.000
44	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2660046	17	12	17	2	3	7	0	7	0	0	0.130	0.550	1.000
45	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2660046	17	12	17	2	3	7	0	7	0	0	0.130	0.550	1.000
46	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	268868	3	2	3	1	0	2	0	1	0	0	0.844	0.575	1.000
47	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(3)	362688	4	2	4	0	1	1	0	2	0	0	0.382	0.576	1.000
48	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(1), ASPH(3), COPS5(1), EP300(14), HIF1A(2), LDHA(4), NOS3(2)	2725738	27	18	27	5	8	6	0	7	6	0	0.202	0.579	1.000
49	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(1), IL12A(1), IL12RB2(5), IL18R1(3), IL2(1), IL2RA(3)	2098879	19	11	20	2	6	6	0	4	3	0	0.0588	0.584	1.000
50	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(1), CTH(1), GOT1(1), LDHA(4), LDHB(3)	1142110	10	6	10	2	2	4	0	3	1	0	0.438	0.584	1.000
51	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(8), ARHGEF1(2), GNA12(1), GNAQ(1), GNGT1(1), MYLK(4), PLCB1(1), PPP1R12B(5), PRKCA(3), ROCK1(8)	3595863	34	21	31	6	8	9	0	10	7	0	0.160	0.585	1.000
52	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), CFTR(5), GNAS(4), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2091976	24	15	24	5	8	7	2	4	3	0	0.183	0.592	1.000
53	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1)	623305	7	3	8	0	2	3	0	1	1	0	0.161	0.597	1.000
54	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2774784	17	12	17	2	3	7	0	7	0	0	0.129	0.606	1.000
55	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(2), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GPX6(1), GSS(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(3), IDH2(1), TXNDC12(2)	3456004	27	20	27	5	5	9	1	9	3	0	0.214	0.607	1.000
56	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), CD3G(1), IL2(1), IL2RA(3), TGFB2(4), TGFBR1(3), TGFBR2(2), TGFBR3(3), TOB1(2)	1854560	21	10	21	3	4	6	0	7	4	0	0.152	0.612	1.000
57	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(3), F2(1), FGA(4), FGB(2), PLAT(1), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(2)	2387283	20	9	19	0	10	5	0	3	2	0	0.00169	0.620	1.000
58	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(14), ESR1(1), MAPK3(1)	2464988	29	18	27	7	6	5	2	9	7	0	0.354	0.624	1.000
59	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(14), NCOA1(2), NCOA2(2)	2975876	31	19	31	6	10	4	2	9	6	0	0.149	0.630	1.000
60	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	SP1(1), SP3(3), WT1(4)	1046582	8	6	8	2	3	1	0	3	1	0	0.448	0.639	1.000
61	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), RB1(16), SP1(1), SP3(3)	1195984	22	19	21	9	5	3	0	10	4	0	0.823	0.640	1.000
62	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(6), MMP9(5), RECK(2), TIMP1(1), TIMP3(1)	1278668	16	10	16	3	8	3	0	3	2	0	0.169	0.652	1.000
63	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), SH3GLB1(1)	2758978	27	15	26	5	5	10	0	10	2	0	0.239	0.657	1.000
64	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), SDHA(2)	1113200	6	5	6	1	1	1	0	4	0	0	0.476	0.658	1.000
65	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(1), ALOX15(1), DPEP1(1), GGT1(2), PLA2G6(2), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2)	2421565	12	12	12	2	6	1	0	0	5	0	0.389	0.659	1.000
66	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(2), HLA-A(3), ITGB1(1), KLRC3(1), KLRC4(1), LAT(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3CA(56), SYK(3), VAV1(2)	2906549	74	44	65	18	5	18	1	44	5	1	0.472	0.660	1.000
67	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), PON1(1), PON2(1), PON3(4), RDH11(1), RDH12(1)	1430039	9	8	7	3	3	2	0	3	1	0	0.653	0.661	1.000
68	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD3G(1)	592941	3	3	3	0	1	0	0	1	1	0	0.559	0.665	1.000
69	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(1), FYN(2), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(9)	1485531	16	8	17	2	3	7	0	2	4	0	0.214	0.666	1.000
70	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), FUT1(3), FUT2(1), FUT9(1), GCNT2(2)	952062	9	6	9	3	4	2	0	0	3	0	0.617	0.667	1.000
71	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(4), PER1(1)	1413270	12	7	12	3	1	4	0	3	3	1	0.571	0.685	1.000
72	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	29	ACVR1(3), ATF2(1), AXIN1(2), BMP10(2), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CHRD(2), CTNNB1(21), FZD1(2), GSK3B(1), MAP3K7(2), NPPB(1), RFC1(5), TGFB2(4), TGFBR1(3), TGFBR2(2), TGFBR3(3)	4814841	61	33	59	12	15	20	0	22	4	0	0.0805	0.686	1.000
73	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(6), GLI3(7), GSK3B(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), SMO(2)	2589451	29	21	29	9	6	9	0	9	5	0	0.525	0.688	1.000
74	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP8(1), CASP9(1), DFFA(2), GZMB(1), PRF1(1), SCAP(3), SREBF2(1)	2931837	24	14	22	3	3	9	1	5	6	0	0.126	0.690	1.000
75	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), IL6(2), LDLR(2)	915304	5	4	5	1	4	0	0	1	0	0	0.364	0.696	1.000
76	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	296271	3	2	3	0	0	2	0	1	0	0	0.434	0.703	1.000
77	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), CYB5R3(1), GCK(3), GFPT1(1), GNE(1), HEXA(1), HEXB(2), HK2(1), HK3(5), PGM3(2)	2908884	20	13	20	2	9	5	0	4	2	0	0.0514	0.707	1.000
78	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(8), PIK3CA(56), WASL(2)	2073562	71	41	62	19	6	17	2	42	4	0	0.471	0.707	1.000
79	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(2)	1772911	10	8	10	2	4	2	0	2	2	0	0.432	0.710	1.000
80	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BIRC3(7), CASP8(1), TNF(1)	1295256	9	6	8	2	2	4	0	1	2	0	0.447	0.719	1.000
81	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(5), CAP1(1), CDC25C(1), GNAI1(2), GNAS(4), GNGT1(1), MAPK3(1), MYT1(5), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	3282282	32	20	32	8	11	9	2	7	3	0	0.244	0.743	1.000
82	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT5(2), FUT1(3), FUT2(1), FUT3(2)	1160693	10	7	10	3	5	2	0	1	2	0	0.673	0.744	1.000
83	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	261192	1	1	1	0	0	0	0	1	0	0	0.767	0.745	1.000
84	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(2), YWHAH(2)	1078865	10	9	12	3	0	5	0	2	3	0	0.614	0.753	1.000
85	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(2), APOBEC4(2)	1276694	9	6	9	2	3	3	0	1	2	0	0.445	0.754	1.000
86	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(1)	642691	3	3	4	0	0	1	0	1	1	0	0.483	0.768	1.000
87	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT2(5), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(5)	2444696	19	13	19	3	9	5	0	5	0	0	0.136	0.776	1.000
88	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(3), G6PD(2), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GSS(1), GSTA2(1), GSTA3(1), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(3), IDH2(1)	3090172	22	17	22	5	4	7	1	7	3	0	0.385	0.778	1.000
89	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(4), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(2)	2049382	17	10	17	4	2	6	0	4	5	0	0.552	0.780	1.000
90	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), CSF1(1), CSF3(1), IL2(1), IL6(2), IL7(1), IL8(1), IL9(1)	1066240	9	5	9	3	5	4	0	0	0	0	0.545	0.784	1.000
91	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(3), SNCAIP(2), UBE2E2(1)	1110643	9	7	9	4	3	5	0	1	0	0	0.774	0.786	1.000
92	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA7(1), PSMB3(1), PSMB8(3)	1474750	7	5	7	0	0	6	1	0	0	0	0.172	0.791	1.000
93	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(1), RAB5A(1), RAB9A(1)	716188	5	3	5	1	1	1	0	2	1	0	0.578	0.795	1.000
94	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	BCR(1), FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PIK3CA(56), RAF1(3), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1)	4312765	96	48	87	23	11	27	2	52	3	1	0.274	0.803	1.000
95	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD3G(1), CD58(1), CD8A(1), CSF3(1), IL6(2), IL8(1)	1119323	8	5	8	2	4	1	0	2	1	0	0.534	0.809	1.000
96	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB4(5), ABCC1(5), ABCC3(1)	2376859	17	10	17	4	5	6	1	4	1	0	0.282	0.816	1.000
97	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDK4(1), CDKN1B(2), CDKN2A(2), PRB1(2)	1145462	7	6	7	5	2	0	0	1	4	0	0.969	0.820	1.000
98	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOC(2)	631920	3	2	3	0	2	0	0	1	0	0	0.415	0.828	1.000
99	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(8), GOT1(1)	1348548	11	6	11	3	3	3	0	2	3	0	0.584	0.835	1.000
100	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(1), CTH(1), MUT(1)	803468	4	3	4	2	1	2	0	0	1	0	0.880	0.837	1.000
101	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(6), ACACB(3), OXSM(4)	2159914	13	11	12	3	3	2	0	5	3	0	0.492	0.840	1.000
102	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(2), GNAQ(1), ITPKB(1)	914798	4	3	4	1	0	1	0	2	1	0	0.644	0.846	1.000
103	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), SQLE(1)	493950	2	2	3	0	0	2	0	0	0	0	0.588	0.849	1.000
104	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), MPO(4), PRDX6(1), TPO(7)	1334550	14	11	14	4	6	5	1	1	1	0	0.492	0.849	1.000
105	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(1), CSK(2), GRB2(2), PRKCA(3), PTPRA(1)	1584281	9	7	9	2	3	5	0	1	0	0	0.435	0.856	1.000
106	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	IL8(1)	262118	1	1	1	0	0	1	0	0	0	0	0.769	0.857	1.000
107	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(2), KERA(2), LUM(2)	621410	7	5	7	3	3	1	0	3	0	0	0.781	0.859	1.000
108	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), DFFA(2), GZMB(1), LMNA(1), LMNB1(2), LMNB2(1), PRF1(1)	3280927	28	13	26	4	6	10	1	4	7	0	0.159	0.864	1.000
109	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), UGDH(1)	1382946	9	5	9	2	1	3	1	2	2	0	0.466	0.864	1.000
110	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(14), CREB3(1), CREB5(3), RAF1(3), SNX13(1), TERF2IP(1)	1904127	24	18	24	7	4	5	2	12	1	0	0.565	0.864	1.000
111	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(2), UXS1(1)	831311	5	3	6	0	0	2	0	2	1	0	0.300	0.867	1.000
112	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), SHC1(1), SOS1(5)	1484162	8	7	8	2	0	3	0	5	0	0	0.610	0.868	1.000
113	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2), SHMT1(1)	828352	3	3	3	2	0	1	0	0	2	0	0.978	0.868	1.000
114	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1)	2095465	10	7	10	1	4	4	0	2	0	0	0.189	0.879	1.000
115	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(5), C6(3), C7(1), C8A(3), C9(1)	2144658	15	9	17	3	5	6	0	2	2	0	0.324	0.881	1.000
116	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	FOS(1), GRB2(2), JAK1(2), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PDGFRA(8), PIK3CA(56), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2)	5744159	107	53	98	24	15	31	3	52	5	1	0.155	0.881	1.000
117	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(2), GAD1(2), GGT1(2)	950667	6	5	6	3	2	2	0	0	2	0	0.905	0.888	1.000
118	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(7), JAK3(4), MAPK3(1)	1951625	14	12	14	7	0	3	0	6	3	2	0.974	0.893	1.000
119	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), METTL2B(1), METTL6(3), PCYT1A(1), PCYT1B(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3)	2285670	14	10	14	4	5	4	0	3	2	0	0.455	0.898	1.000
120	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	FOS(1), GRB2(2), INSR(1), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(56), PTPN11(10), RAF1(3), RASA1(4), SHC1(1), SLC2A4(1), SOS1(5)	3949324	97	48	88	25	11	25	2	54	5	0	0.329	0.900	1.000
121	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CDKN2A(2), PRB1(2)	1438828	10	6	10	7	2	1	0	2	5	0	0.966	0.901	1.000
122	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), ACADS(1), ECHS1(1), HADHA(2)	915561	9	6	9	4	3	2	0	0	4	0	0.842	0.904	1.000
123	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(2)	471862	3	1	3	2	0	2	0	0	1	0	0.892	0.906	1.000
124	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(1), CFLAR(1)	648979	3	2	3	0	0	1	0	1	1	0	0.632	0.907	1.000
125	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(13), EP300(14), NCOA3(7), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RARA(1)	3505195	45	24	43	10	11	11	2	12	9	0	0.215	0.911	1.000
126	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), MAPK8(6), PLCG1(2), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1)	3652147	33	20	33	8	7	7	1	16	1	1	0.421	0.913	1.000
127	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(1), GALNT12(1), GALNT13(1), GALNT14(1), GALNT2(5), GALNT5(7), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(5)	5565557	46	24	45	9	13	17	0	14	2	0	0.122	0.914	1.000
128	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(3), FSHB(2), FSHR(3), GNAS(4), XPO1(2)	1531736	19	17	19	6	6	2	3	6	2	0	0.592	0.916	1.000
129	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ESR1(1), GREB1(5), HSPB2(1), MTA3(1), TUBA8(1)	1533189	9	7	10	2	3	3	0	2	1	0	0.430	0.916	1.000
130	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	23	CASP3(1), CREB3(1), CREB5(3), DAG1(2), EPHB2(1), FOS(1), GNAQ(1), ITPKB(1), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3)	3337458	32	16	32	5	9	8	2	7	6	0	0.0463	0.919	1.000
131	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ARG2(1), ASL(2), CKB(1), CKM(1), CKMT2(4), CPS1(8), NAGS(1), OAT(1), ODC1(3), OTC(3)	2950251	26	12	26	6	10	6	1	5	4	0	0.261	0.921	1.000
132	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(9), IL6(2), IL9(1), TGFB2(4)	1441978	17	11	16	6	3	8	0	4	2	0	0.640	0.922	1.000
133	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(2)	950094	7	3	7	2	4	1	1	0	1	0	0.481	0.922	1.000
134	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(2)	950094	7	3	7	2	4	1	1	0	1	0	0.481	0.922	1.000
135	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(2), B4GALT5(1), FUT8(1), ST3GAL1(1)	1308066	6	6	6	2	3	1	0	1	1	0	0.687	0.924	1.000
136	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), GGPS1(1), SQLE(1)	689259	3	2	4	1	0	3	0	0	0	0	0.749	0.927	1.000
137	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(3), WASL(2)	1405901	11	4	11	1	4	2	0	3	2	0	0.143	0.930	1.000
138	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	GRB2(2), IGF1R(5), IRS1(4), MAP2K1(2), MAPK3(1), PIK3CA(56), RAF1(3), SHC1(1), SOS1(5), YWHAH(2)	2839873	81	46	72	23	7	20	1	49	4	0	0.564	0.930	1.000
139	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), HSD3B1(1), HSD3B2(1)	1146613	6	6	6	3	1	3	0	1	1	0	0.835	0.932	1.000
140	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(8)	1301269	10	4	10	4	1	4	0	5	0	0	0.783	0.936	1.000
141	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	FOS(1), GRB2(2), MAP2K1(2), MAPK3(1), MAPK8(6), NGFR(1), PIK3CA(56), PLCG1(2), RAF1(3), SHC1(1), SOS1(5)	2911768	80	44	71	21	8	20	2	48	2	0	0.438	0.939	1.000
142	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(2)	690278	2	2	2	0	0	2	0	0	0	0	0.625	0.940	1.000
143	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	CASP9(1), CDC42(1), CHUK(4), MAP2K1(2), MAPK3(1), NFKB1(3), PIK3CA(56), RAF1(3), RALA(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1)	2892079	78	46	69	22	10	16	2	47	3	0	0.523	0.940	1.000
144	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(14), CREB3(1), CREB5(3), DUSP6(1), EEF2K(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(1), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(5), SOS2(2), TRAF3(2)	5061440	52	28	49	12	8	17	2	21	4	0	0.243	0.942	1.000
145	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CD3G(1), CXCR3(1), ETV5(2), IL12A(1), IL12RB2(5), IL18R1(3), JAK2(7), MAP2K6(1), MAPK14(1), MAPK8(6), STAT4(3)	3194622	32	19	32	9	3	9	1	15	3	1	0.667	0.942	1.000
146	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(2), PSMD2(1), PSMD6(3)	2859624	16	7	15	1	5	7	0	3	1	0	0.0620	0.944	1.000
147	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	NR3C1(3), TNF(1)	931316	4	4	3	2	0	0	0	3	1	0	0.854	0.944	1.000
148	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), AKT3(1), GRB2(2), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(1), PIK3CA(56), PIK3CD(1), SHC1(1), SOS1(5)	2563797	72	40	63	20	5	19	1	46	1	0	0.574	0.944	1.000
149	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(37), CDC25C(1), CHEK1(1), MYT1(5), YWHAH(2)	2419065	46	30	44	12	5	16	2	17	4	2	0.489	0.948	1.000
150	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), NOS1(8), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3)	4173987	41	22	41	10	18	13	0	6	3	1	0.104	0.948	1.000
151	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOC(2), FBP2(1), FPGT(3), GCK(3), GMDS(1), GMPPA(1), HK2(1), HK3(5), PFKFB1(2), PFKFB3(1), PFKM(3), PFKP(1), PMM1(2), SORD(2)	4045688	31	18	31	6	13	10	1	6	1	0	0.0849	0.949	1.000
152	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(2), FBP2(1), G6PD(2), GPI(1), H6PD(1), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TAL1(1), TKT(1)	3278698	20	15	20	4	8	7	0	4	1	0	0.172	0.950	1.000
153	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1)	1353865	7	4	7	3	1	2	1	2	1	0	0.790	0.951	1.000
154	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1)	1353865	7	4	7	3	1	2	1	2	1	0	0.790	0.951	1.000
155	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1)	950968	7	6	6	4	0	2	0	3	2	0	0.907	0.952	1.000
156	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2)	1753794	11	8	11	4	8	1	1	0	1	0	0.490	0.954	1.000
157	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(1), B4GALT3(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), ST3GAL6(4)	2281431	22	13	22	5	8	4	1	5	4	0	0.325	0.955	1.000
158	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(1), CTH(1), GOT1(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), SULT1B1(1)	2143492	13	6	13	4	2	5	0	5	1	0	0.639	0.955	1.000
159	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ANKRD1(2), IFRD1(5), IL1R1(1), MYOG(1), NR4A3(2)	1772508	11	5	11	1	4	4	0	2	1	0	0.139	0.955	1.000
160	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), DFFA(2), GZMB(1), TOP2A(1), TOP2B(1)	1339637	6	5	13	2	0	3	0	2	1	0	0.767	0.956	1.000
161	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(2), JAK1(2), STAT1(2), STAT5A(2), TNF(1)	2077874	13	9	13	4	5	3	0	2	2	1	0.574	0.958	1.000
162	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	AXIN1(2), BTRC(4), CREBBP(13), CSNK1D(1), CTNNB1(21), FZD1(2), GSK3B(1), MAP3K7(2), PPARD(1)	3620728	47	32	43	11	8	11	2	22	4	0	0.257	0.959	1.000
163	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(5), ABCG2(5), BCHE(4), CES1(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1)	4085275	26	15	26	5	6	12	1	5	2	0	0.120	0.960	1.000
164	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(3), MAPK3(1), MAPK8IP3(1), PAPPA(6), RPS6KA3(3), SHC1(1), SOS1(5), SYK(3), VAV1(2), VAV2(2), VAV3(3)	5192774	38	19	38	7	8	18	0	8	4	0	0.125	0.961	1.000
165	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2), HADHA(2)	838193	5	5	4	4	0	1	0	2	2	0	0.982	0.961	1.000
166	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(1), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(2), PTPRC(9)	2313659	21	9	25	6	3	9	0	4	5	0	0.510	0.961	1.000
167	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(1), UBE2C(1), UBE2D3(1), UBE2I(1), UBE3A(6)	1741854	11	4	11	2	3	5	0	2	1	0	0.343	0.962	1.000
168	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(1), ADCY9(3), AK1(1), ARF4(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(2), PLCG1(2), PLCG2(5), PRKCA(3), SEC61A1(1), TRIM23(5)	6247478	47	29	47	10	18	11	2	13	3	0	0.0910	0.962	1.000
169	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), MPO(4), PRDX1(1), PRDX6(1), TPO(7), TYR(3)	1534444	18	14	18	5	7	5	2	2	2	0	0.435	0.963	1.000
170	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	FOS(1), MAPK14(1), MAPK8(6), NFE2L2(3), PRKCA(3)	1386831	14	7	14	3	5	4	1	3	1	0	0.313	0.964	1.000
171	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(2), PRKCA(3)	1149145	7	7	7	3	4	2	0	1	0	0	0.741	0.965	1.000
172	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(1), ALAS2(2), CPO(1), FECH(1), GATA1(1), HBB(1), HMBS(1), UROD(1)	1425802	10	6	10	2	4	4	0	1	1	0	0.377	0.965	1.000
173	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA7(1), PSMB3(1), RPN2(1), UBE2A(1), UBE3A(6)	2276875	12	5	12	1	3	8	0	1	0	0	0.140	0.966	1.000
174	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3)	1403855	9	7	9	4	3	3	0	1	2	0	0.776	0.967	1.000
175	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	FOS(1), GRB2(2), IGF1R(5), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(56), PTPN11(10), RAF1(3), RASA1(4), SHC1(1), SOS1(5)	3826486	100	50	91	28	11	26	2	57	4	0	0.451	0.967	1.000
176	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(1), JAK1(2), JAK2(7), STAT1(2)	1471216	14	10	14	6	2	3	0	6	1	2	0.901	0.968	1.000
177	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR1H4(2)	866845	4	2	4	1	3	0	0	1	0	0	0.507	0.968	1.000
178	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(2), IL2RG(1), IRS1(4), JAK1(2), JAK3(4), SHC1(1)	2365858	14	9	14	4	2	3	0	4	4	1	0.680	0.968	1.000
179	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(1), HADHA(2), HADHB(1), HSD17B10(1), PPT2(1)	1461136	8	7	8	4	2	3	0	0	3	0	0.882	0.969	1.000
180	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	APAF1(4), ATM(37), BAX(2), CASP3(1), CASP6(1), CASP9(1), PRKCA(3), STAT1(2), TLN1(2)	4567683	53	32	50	12	4	19	2	19	7	2	0.360	0.969	1.000
181	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(4), CSNK1D(1), NR1D1(1), PER1(1), PER2(2), PER3(2)	2824446	18	9	18	4	3	5	0	5	4	1	0.358	0.971	1.000
182	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	23	AXIN1(2), CTNNB1(21), FZD1(2), GJA1(4), GNAI1(2), GSK3B(1), LBP(1), MYD88(1), NFKB1(3), PIK3CA(56), RELA(1), TLR4(3)	3505849	97	52	86	28	14	27	1	54	1	0	0.473	0.972	1.000
183	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(4), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), SCLY(1), SEPHS1(2)	4047222	27	14	27	7	5	9	0	6	7	0	0.451	0.972	1.000
184	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPPL2(1), GGH(1)	863637	2	2	2	1	1	1	0	0	0	0	0.749	0.972	1.000
185	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(1), MNAT1(1), XPO1(2)	1503369	4	4	4	2	1	1	0	2	0	0	0.880	0.973	1.000
186	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT2(1), FUT9(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1)	1601269	10	8	10	4	5	1	0	2	2	0	0.721	0.974	1.000
187	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR3(2), CCR4(1), CCR7(2), CD28(1), CXCR3(1), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12A(1), IL12RB2(5), IL18R1(3), IL2(1), TGFB2(4)	3493036	26	13	26	5	6	10	0	7	3	0	0.137	0.975	1.000
188	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(2), CBS(1), CTH(1), DNMT1(8), DNMT3A(2), DNMT3B(6), MARS(4), MARS2(1), MAT2B(1), MTR(1)	2950110	28	13	28	8	12	10	1	1	4	0	0.352	0.976	1.000
189	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(5), AASDHPPT(1), AASS(3)	1252249	10	9	10	4	0	4	0	5	1	0	0.843	0.977	1.000
190	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(2)	1320519	10	5	10	3	2	6	0	0	2	0	0.739	0.978	1.000
191	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), ACTR3(1), ANGPTL2(1), DAG1(2), ETFA(1), ITGA9(4), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(2), PDE3B(2), PI3(1), PIK3C2G(2), PIK3CA(56), PIK3CD(1), RIPK3(1), RPS4X(2), SGCB(4)	7436000	103	55	102	25	16	26	1	49	9	2	0.245	0.979	1.000
192	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	CREBBP(13), EP300(14), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(2), TGFB2(4), TGFBR1(3), TGFBR2(2)	3183929	43	24	41	11	7	7	2	17	10	0	0.373	0.979	1.000
193	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(3), CBX3(1), CLOCK(4), CRY1(4), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(2), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(3), PER1(1), PER2(2), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(2), UGP2(2), ZFR(6)	6189521	48	17	48	8	8	17	0	16	6	1	0.0778	0.979	1.000
194	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD5(2), CD7(2), IFNA1(1), IL10(1), IL12A(1), ITGAX(2), TLR2(5), TLR4(3), TLR7(3), TLR9(4)	3128816	28	10	28	6	9	11	0	5	3	0	0.164	0.980	1.000
195	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3)	2311707	11	7	11	4	4	3	0	2	2	0	0.626	0.980	1.000
196	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	27	AKT2(1), AKT3(1), AXIN1(2), AXIN2(3), CER1(2), CTNNB1(21), DACT1(1), DKK1(1), DKK2(3), DKK3(2), DKK4(3), FSTL1(1), GSK3B(1), LRP1(4), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(1), TSHB(1)	5381831	51	36	49	11	10	17	0	21	3	0	0.219	0.981	1.000
197	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), SP1(1), SP3(3)	3331951	22	16	22	6	12	3	0	3	4	0	0.345	0.982	1.000
198	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFS1(2), NDUFS2(3)	1237909	6	4	6	2	3	2	0	0	1	0	0.708	0.984	1.000
199	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(2), MAPK14(1), THBS1(2)	1238686	7	4	7	3	2	3	0	2	0	0	0.783	0.984	1.000
200	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR2(1), JAK1(2), STAT1(2), STAT2(2)	1840346	8	5	8	5	1	3	0	1	2	1	0.938	0.984	1.000
201	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST6GALNAC2(1), ST6GALNAC4(1)	931278	3	3	3	2	1	2	0	0	0	0	0.829	0.985	1.000
202	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), PDE6A(2), PDE6C(2), SLC6A13(1), TF(5)	5670315	29	17	36	5	8	11	0	5	4	1	0.0884	0.985	1.000
203	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(7), JAK3(4), PTPRU(6), REG1A(2)	2239579	21	16	21	8	8	3	0	6	2	2	0.835	0.987	1.000
204	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(13), EP300(14), FYN(2), IL2RG(1), IL7(1), IL7R(1), JAK1(2), JAK3(4), LCK(1), NMI(1), PIK3CA(56), STAT5A(2), STAT5B(1)	4510819	99	46	88	27	12	26	3	47	10	1	0.512	0.987	1.000
205	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD3G(1), CD8A(1), ITGAL(3), ITGB2(2), PTPRC(9)	1804762	18	9	18	6	4	7	0	2	5	0	0.531	0.987	1.000
206	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(3), TGM2(2)	840874	7	4	7	2	4	3	0	0	0	0	0.392	0.988	1.000
207	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(2)	1216574	6	2	6	0	0	4	0	2	0	0	0.224	0.988	1.000
208	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPN2(2), EP300(14), NFATC1(2), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3)	3880987	30	20	30	8	12	7	0	5	6	0	0.310	0.988	1.000
209	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	MAP2K3(3), MAPK14(1), NFATC1(2), NFATC2(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	1748308	18	14	18	9	7	4	1	4	2	0	0.826	0.989	1.000
210	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(1), EGFR(11), RAB5A(1), TF(5), TFRC(2)	2225766	24	16	24	9	6	7	0	9	2	0	0.747	0.989	1.000
211	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), TAT(2), TYR(3)	838749	6	4	6	4	1	2	1	1	1	0	0.923	0.989	1.000
212	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(9), MAP2(9), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(2), PRKCE(2)	3143960	26	17	24	8	6	7	0	9	4	0	0.707	0.990	1.000
213	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	CHST11(2), CHST12(2), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(2)	1643331	10	5	10	3	3	4	0	3	0	0	0.571	0.990	1.000
214	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(5), CAMK2D(1), GNAS(4), GRB2(2), MAPK14(1), MAPK3(1), PIK3CA(56), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), RPS6KA5(3), SOS1(5)	4553843	91	49	82	24	15	22	3	47	4	0	0.420	0.991	1.000
215	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD3G(1), ITGAL(3), ITGB2(2), PTPRC(9)	1921983	17	8	17	6	3	7	0	2	5	0	0.600	0.991	1.000
216	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	2914484	13	8	13	3	2	6	0	3	2	0	0.409	0.991	1.000
217	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(2), JAK2(7)	1785790	12	9	12	9	1	4	0	5	0	2	0.993	0.991	1.000
218	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(2), JAK2(7)	1785790	12	9	12	9	1	4	0	5	0	2	0.993	0.991	1.000
219	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	FAU(1), MRPL13(2), RPL10A(1), RPL11(2), RPL19(1), RPL28(1), RPL6(2), RPL7(1), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(2), RPS6(1)	3388037	19	12	19	4	2	6	1	8	2	0	0.432	0.991	1.000
220	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(2), FBP2(1), G6PD(2), GPI(1), H6PD(1), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TKT(1), TKTL1(1), TKTL2(3)	3870101	23	17	23	6	8	8	1	5	1	0	0.280	0.992	1.000
221	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CYP2C19(1), CYP2C9(3), DHRS2(1), ECHS1(1), EHHADH(2), ESCO1(6), ESCO2(5), HADHA(2), MYST3(6), MYST4(8), SH3GLB1(1)	5212221	44	20	42	11	7	15	1	16	5	0	0.395	0.992	1.000
222	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AMD1(1), AOC3(1), ARG2(1), ASL(2), ASS1(1), CPS1(8), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(3), SAT1(1), SAT2(1)	5020824	41	21	40	11	13	12	1	7	8	0	0.277	0.992	1.000
223	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(3), FYN(2), LRP8(4), RELN(12), VLDLR(2)	2430400	24	14	24	9	6	11	1	4	2	0	0.724	0.992	1.000
224	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP5(8), ARHGAP6(1), ARHGEF1(2), ARHGEF11(4), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(4), OPHN1(4), PIP5K1B(1), PPP1R12B(5), ROCK1(8), TLN1(2), VCL(1)	7880187	45	24	42	8	9	11	0	15	10	0	0.114	0.993	1.000
225	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), FOS(1), GNAI1(2), GNAQ(1), GNAS(4), GNGT1(1), MAP2K1(2), MAPK3(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), RAF1(3), RPS6KA3(3)	5578735	50	30	50	12	21	10	2	11	6	0	0.134	0.993	1.000
226	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	12	AXIN1(2), CREBBP(13), CTNNB1(21), EP300(14), FZD1(2), GSK3B(1), LDB1(2), TRRAP(9)	4455686	64	37	59	16	12	14	2	27	9	0	0.263	0.993	1.000
227	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(8), DNMT3A(2), DNMT3B(6), MARS(4), MARS2(1), MAT2B(1), MTAP(1), MTR(1), TAT(2)	3468659	32	13	32	9	12	14	1	1	4	0	0.328	0.993	1.000
228	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	679251	1	1	1	1	0	1	0	0	0	0	0.952	0.994	1.000
229	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), SULT2A1(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	4588575	23	16	23	5	5	11	0	4	3	0	0.245	0.994	1.000
230	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1)	2844682	25	16	25	8	5	5	0	13	1	1	0.700	0.994	1.000
231	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(2), NR1I3(2), PTGS1(1), PTGS2(1)	921354	7	6	7	4	4	1	0	1	1	0	0.867	0.994	1.000
232	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(5), GNAI1(2), GNGT1(1), ITGAV(4), ITGB3(4), MAPK3(1), PDGFRA(8), PIK3CA(56), PLCB1(1), PRKCA(3), SMPD1(1), SPHK1(1)	4392227	87	52	78	26	10	24	3	43	7	0	0.604	0.994	1.000
233	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CDK5(1), CHN1(1), LIMK1(1), MAP3K1(3), MYLK(4), NCF2(2), PAK1(1), PDGFRA(8), PIK3CA(56), PLD1(3), PPP1R12B(5), RALBP1(2), TRIO(2), VAV1(2), WASF1(3)	5704730	94	48	85	23	12	29	2	45	6	0	0.292	0.994	1.000
234	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(4), CLTA(1), CLTB(1), COPA(1), GBF1(2), GPLD1(4), KDELR2(1)	2845724	14	7	14	4	6	3	0	3	2	0	0.502	0.995	1.000
235	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	14	B3GNT2(1), B4GALT1(1), B4GALT3(2), CHST1(1), CHST2(2), CHST4(2), FUT8(1), ST3GAL1(1)	1771665	11	9	11	5	6	1	1	1	2	0	0.785	0.995	1.000
236	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2)	1336344	9	7	8	5	1	3	0	3	2	0	0.933	0.995	1.000
237	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(2), HADHA(2), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1)	2030764	11	8	10	6	1	3	0	3	4	0	0.940	0.995	1.000
238	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRB(1), CP(6), CPOX(1), EPRS(4), FECH(1), HCCS(2), HMBS(1), HMOX2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1)	4644381	27	17	27	5	5	13	0	6	3	0	0.205	0.995	1.000
239	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), MBTPS1(3), SCAP(3), SREBF2(1)	1836476	9	4	9	3	3	2	0	3	1	0	0.562	0.995	1.000
240	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CSNK1D(1), DRD2(2), GRM1(5), PLCB1(1), PPP3CA(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2656434	22	15	22	8	10	4	1	4	3	0	0.565	0.995	1.000
241	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(2), PTPRU(6), REG1A(2), STAT1(2), STAT2(2)	2115965	14	11	14	6	9	2	0	1	1	1	0.749	0.996	1.000
242	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(2), FUT1(3), FUT2(1), FUT9(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1)	1712522	13	8	13	5	7	1	0	3	2	0	0.657	0.996	1.000
243	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), DHRS2(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), SH3GLB1(1)	4137342	38	22	36	10	6	13	0	14	5	0	0.442	0.996	1.000
244	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(6), ACACB(3), ACADM(3), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ALDH7A1(2), ECHS1(1), EHHADH(2), HADHA(2), HIBCH(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), MCEE(2), MUT(1), PCCA(6), PCCB(1), SUCLA2(3), SUCLG1(1)	6985794	53	24	52	11	9	18	1	15	10	0	0.174	0.996	1.000
245	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT2(1), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1)	1463516	9	9	8	7	1	4	0	2	2	0	0.983	0.996	1.000
246	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(4), FOS(1), IKBKB(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(6), MYD88(1), NFKB1(3), RELA(1), TLR10(3), TLR2(5), TLR3(2), TLR4(3), TLR6(2), TLR7(3), TLR9(4)	6044138	54	21	54	14	14	21	2	13	3	1	0.265	0.996	1.000
247	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), FH(1), IDH1(3), IDH2(1), SUCLA2(3)	1561900	9	9	9	7	1	3	0	4	1	0	0.989	0.996	1.000
248	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	GRB2(2), NTRK1(1), PIK3CA(56), PLCG1(2), PRKCA(3), SHC1(1), SOS1(5)	2367086	70	42	61	20	6	18	1	44	1	0	0.642	0.996	1.000
249	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(2), JAK2(7), PTPRU(6), REG1A(2), STAT1(2)	1980539	21	16	21	8	10	3	0	6	0	2	0.781	0.996	1.000
250	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(1), ENPP3(2), TYR(3)	1697709	7	6	7	5	2	1	1	1	1	1	0.962	0.997	1.000
251	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(4), ACTN2(4), BCAR1(1), BCR(1), CAV1(1), CSK(2), FYN(2), GRB2(2), ITGB1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MAPK8(6), PPP1R12B(5), RAF1(3), RAP1A(1), ROCK1(8), SHC1(1), SOS1(5), TLN1(2), VCL(1), ZYX(3)	7521569	59	27	59	10	15	19	1	17	7	0	0.0370	0.997	1.000
252	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2)	2193948	16	8	15	6	1	5	1	5	4	0	0.738	0.997	1.000
253	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(3), ITGAM(1), ITGB2(2), SELE(2)	1603012	9	7	11	5	2	5	0	0	2	0	0.822	0.997	1.000
254	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	4	AOX1(3), PSAT1(1)	802966	4	1	4	1	0	3	0	0	1	0	0.791	0.997	1.000
255	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(3)	851050	5	5	5	3	0	1	0	3	1	0	0.925	0.997	1.000
256	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(6), ITGAL(3), ITGB1(1), ITGB2(2), SELE(2)	2035867	15	8	15	6	1	9	0	2	3	0	0.763	0.997	1.000
257	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1)	1751734	7	5	8	3	3	2	0	2	0	0	0.755	0.997	1.000
258	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), ALAS2(2), CPOX(1), FECH(1), HMBS(1), UROD(1)	1346499	8	5	8	2	4	2	0	2	0	0	0.578	0.997	1.000
259	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD3G(1), CXCR3(1), IL12A(1), IL12RB2(5), JAK2(7), STAT4(3)	2543566	19	14	19	6	1	4	0	12	1	1	0.791	0.997	1.000
260	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	CHRNG(2), MUSK(2), PIK3CA(56), TERT(2), YWHAH(2)	2319016	64	40	56	20	6	16	1	38	3	0	0.772	0.997	1.000
261	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(1), JAK1(2), JAK2(7), JAK3(4), STAT1(2), STAT5A(2), STAT5B(1)	3050502	19	15	19	8	2	5	0	7	3	2	0.913	0.998	1.000
262	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), GPT(1), LDHA(4), LDHB(3), MAPK14(1), NCL(2)	1499594	15	12	15	6	4	6	0	5	0	0	0.767	0.998	1.000
263	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), UGDH(1), UGP2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2)	4350842	26	12	26	4	2	13	0	7	4	0	0.137	0.998	1.000
264	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), MPL(4), PIK3CA(56), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1), THPO(1)	4911872	97	49	88	25	13	25	1	54	3	1	0.414	0.998	1.000
265	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(4), CDK5(1), CSNK1D(1), GSK3B(1), MAPT(1)	1350858	8	6	7	4	4	1	0	3	0	0	0.809	0.998	1.000
266	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C9(1)	3468902	24	11	26	6	7	10	0	5	2	0	0.367	0.998	1.000
267	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(1), RDH12(1)	804597	2	1	2	1	1	1	0	0	0	0	0.778	0.998	1.000
268	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), CSF3(1), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IL10(1), IL12A(1), IL2(1), IL6(2), IL7(1), IL8(1), TGFB2(4), TNF(1)	2188764	17	7	18	6	5	7	0	2	3	0	0.641	0.998	1.000
269	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IL10(1), IL12A(1), IL16(4), IL2(1), IL6(2), IL8(1), IL9(1), TNF(1)	1666062	13	4	13	7	3	7	0	1	2	0	0.885	0.998	1.000
270	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ERCC3(1), GTF2B(1), GTF2F2(1), GTF2H1(2), MNAT1(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3B(6), POLR3E(3), POLR3K(1), TAF12(1), TAF5(2), TAF6(1), TAF7(1), TAF9(1)	6077764	34	18	34	6	13	10	0	4	7	0	0.112	0.998	1.000
271	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(1), LPO(1), MPO(4), PRDX1(1), PRDX6(1), SHMT1(1), TPO(7)	1882215	18	13	18	7	6	6	1	2	3	0	0.698	0.998	1.000
272	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(6), PAK1(1), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5)	4757676	40	24	40	10	8	12	2	15	3	0	0.338	0.998	1.000
273	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(5), ARHGEF1(2), F2(1), GNA12(1), GNAI1(2), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(56), PLCB1(1), PPP1R12B(5), PRKCA(3), ROCK1(8)	4079106	88	50	79	24	12	23	1	44	8	0	0.495	0.999	1.000
274	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(2), FUCA1(2), FUCA2(1), HEXA(1), HEXB(2), LCT(7), MAN2C1(1), MANBA(1)	2613226	17	11	17	6	6	3	0	4	4	0	0.677	0.999	1.000
275	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR1(1), GOSR2(1), SNAP25(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX5(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1)	2734022	16	6	16	4	5	5	0	3	3	0	0.432	0.999	1.000
276	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	ACHE(2), CHAT(1), DBH(1), GAD1(2), HDC(6), MAOA(2), PAH(2), SLC18A3(1), TPH1(2)	2204404	19	15	19	9	5	10	0	2	2	0	0.865	0.999	1.000
277	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(1), LPO(1), MPO(4), MTHFR(1), PRDX6(1), SHMT1(1), TPO(7)	1868579	18	13	18	6	7	6	1	2	2	0	0.595	0.999	1.000
278	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C8B(1), C9(1), MASP1(4)	4059879	29	14	31	6	9	12	0	6	2	0	0.193	0.999	1.000
279	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(2), ATP7B(2), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(2), SHMT1(1)	6710523	38	24	37	9	7	15	0	13	3	0	0.268	0.999	1.000
280	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(1), GNAQ(1), MAPK14(1), MAPK8(6), PLCG1(2), PRKCA(3)	2351619	15	10	15	5	5	4	1	4	1	0	0.633	0.999	1.000
281	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(4), CREBBP(13), DUSP1(1), EP300(14), IKBKB(2), IL1B(1), IL8(1), MAP2K3(3), MAP2K6(1), MAP3K7(2), MAPK14(1), MYD88(1), NFKB1(3), NR3C1(3), RELA(1), TGFBR1(3), TGFBR2(2), TLR2(5), TNF(1)	4940131	62	30	59	17	14	10	3	25	10	0	0.389	0.999	1.000
282	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(6), CPT1A(3), LEPR(6), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKAG1(1), PRKAG2(1)	2589141	25	15	25	8	9	6	0	8	2	0	0.658	0.999	1.000
283	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGF(1), EGFR(11), FOS(1), GRB2(2), JAK1(2), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PIK3CA(56), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2)	6211175	111	54	102	29	17	30	2	57	4	1	0.356	0.999	1.000
284	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C9(1), MASP1(4)	4137516	28	14	30	7	9	11	0	6	2	0	0.306	0.999	1.000
285	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(4), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF13B(1), TNFSF13B(1), TRAF3(2), TRAF5(2)	2362416	21	10	21	8	5	5	1	7	3	0	0.797	0.999	1.000
286	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), STS(1), SULT1E1(1), SULT2A1(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2)	8106283	49	25	49	12	10	21	0	11	7	0	0.181	0.999	1.000
287	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(3), CAMKK2(1)	1953290	9	5	9	3	1	5	0	2	1	0	0.705	0.999	1.000
288	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(7), PGM1(2), PYGL(2), PYGM(2)	2239402	13	9	13	5	8	2	0	2	1	0	0.663	0.999	1.000
289	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2B(1), GTF2F1(2), NCOA1(2), NCOA2(2), NCOA3(7), NCOR2(6), POLR2A(2), RARA(1)	3932288	25	16	25	8	9	8	0	4	4	0	0.649	0.999	1.000
290	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(1), CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SPN(2), TGFB2(4), TNF(1), TNFRSF8(1), TNFSF8(2)	2136358	17	12	17	8	4	6	0	5	2	0	0.817	0.999	1.000
291	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CD3D(1), CD3G(1), FOS(1), FYN(2), GRB2(2), LAT(1), LCK(1), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), PIK3CA(56), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), PTPN7(1), RAF1(3), RASA1(4), RELA(1), SHC1(1), SOS1(5), VAV1(2)	7679101	118	58	109	29	25	33	2	51	7	0	0.165	0.999	1.000
292	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), AKT3(1), GRB2(2), IARS(1), IL13RA1(1), IL2RG(1), INPP5D(2), JAK1(2), JAK2(7), JAK3(4), PI3(1), PIK3CA(56), PPP1R13B(1), SERPINA4(5), SHC1(1), SOS1(5), SOS2(2)	6105804	93	46	84	23	8	24	1	53	5	2	0.407	1.000	1.000
293	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(1), ALAS2(2), BLVRB(1), COX15(3), CP(6), CPOX(1), EPRS(4), FECH(1), FTMT(1), HCCS(2), HMBS(1), HMOX2(2), MMAB(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2), UROD(1)	6952068	48	23	48	9	10	23	0	10	5	0	0.0965	1.000	1.000
294	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(2), ATF2(1), EGFR(11), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), MEF2A(2), PAK1(1), PRKCA(3), RAF1(3), SHC1(1), SOS1(5)	5740220	51	29	52	13	9	15	1	22	4	0	0.331	1.000	1.000
295	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	CBL(7), CFLAR(1), FOS(1), GRB2(2), IL2RA(3), IL2RB(1), IL2RG(1), IRS1(4), JAK1(2), JAK3(4), MAPK3(1), NMI(1), PIK3CA(56), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(3)	5577966	99	44	90	26	13	25	1	50	9	1	0.459	1.000	1.000
296	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(4), PGAP1(3), PIGG(3), PIGK(2), PIGM(2), PIGN(1), PIGO(2), PIGP(1), PIGS(2), PIGT(2), PIGU(1), PIGV(2), PIGX(2)	3987704	28	13	29	9	6	13	0	4	5	0	0.616	1.000	1.000
297	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1)	4032729	23	11	23	3	10	10	0	2	1	0	0.0667	1.000	1.000
298	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), CHIT1(2), CMAS(3), CYB5R1(2), CYB5R3(1), GFPT1(1), GFPT2(1), GNE(1), HEXA(1), HEXB(2), HK2(1), HK3(5), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), NANS(1), NPL(1), PGM3(2)	4915368	30	18	30	9	13	8	1	5	3	0	0.433	1.000	1.000
299	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(6), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), SELE(2), SELP(2)	2579976	18	11	20	8	3	9	0	2	4	0	0.799	1.000	1.000
300	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), GRHPR(1), HAO2(1), MTHFD1(1), MTHFD1L(2)	2251392	6	5	6	6	1	2	1	1	1	0	0.990	1.000	1.000
301	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(2), NTRK1(1), PIR(1), PSMA7(1), WASF1(3), WASF3(3), WASL(2)	2663951	19	8	19	6	6	6	0	4	3	0	0.615	1.000	1.000
302	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACSS1(1), ACSS2(1), FH(1), IDH1(3), IDH2(1), SUCLA2(3)	2321219	11	10	11	8	1	4	0	5	1	0	0.986	1.000	1.000
303	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C2(1), AKR1C3(2), AKR1C4(2), ALDH1A3(2), ALDH3B2(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(1), CYP3A43(3), CYP3A7(2), GSTA2(1), GSTA3(1), GSTA5(2), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2)	9468722	64	28	63	15	9	22	0	22	11	0	0.189	1.000	1.000
304	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	24	AKT2(1), AKT3(1), GRB2(2), GSK3B(1), IRS1(4), JAK1(2), JAK3(4), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(56), PIK3CD(1), PPP1R13B(1), RAF1(3), SHC1(1), SOS1(5), SOS2(2)	5543369	88	45	79	24	10	23	1	47	6	1	0.481	1.000	1.000
305	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	GNS(3), HEXA(1), HEXB(2), LCT(7), NAGLU(1)	2363965	14	8	14	7	5	4	0	3	2	0	0.842	1.000	1.000
306	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1(1), MTHFD1L(2)	2358168	7	6	7	6	2	2	1	1	1	0	0.979	1.000	1.000
307	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ECHS1(1), EHHADH(2), HADHA(2)	2071514	12	8	11	7	1	3	1	4	3	0	0.962	1.000	1.000
308	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), BIN1(3), DNM1(3), EPN1(1), EPS15(3), PICALM(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(1)	3767637	25	14	25	8	10	8	1	3	3	0	0.470	1.000	1.000
309	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	2135219	7	4	8	3	3	3	0	1	0	0	0.718	1.000	1.000
310	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(3), AGT(2), AGTR1(2), AGTR2(2), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(3), REN(2)	3576498	30	12	30	9	9	13	0	6	2	0	0.383	1.000	1.000
311	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(2), MAP2K5(2), MAPK8(6), PLD1(3), PLD2(3), RAF1(3), RASAL1(2), TEC(2), VAV1(2)	4613190	29	13	29	8	10	9	1	8	1	0	0.410	1.000	1.000
312	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(1), F3(1), F5(7), F7(1), FGA(4), FGB(2), PROS1(3), TFPI(3)	2794202	22	8	22	8	6	7	0	7	2	0	0.713	1.000	1.000
313	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(6), ACADL(2), ACADM(3), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ECHS1(1), EHHADH(2), HADHA(2), LDHA(4), LDHB(3), MCEE(2), MUT(1), PCCA(6), PCCB(1), SUCLA2(3), SUCLG1(1)	5826630	46	23	45	12	10	14	1	12	9	0	0.415	1.000	1.000
314	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(4), BAX(2), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), FAS(2), GZMB(1), MAP2K4(4), MAP3K1(3), MAPK10(4), NFKB1(3), PARP1(1), PRF1(1), RELA(1), TNF(1), TNFSF10(1), TRAF1(2)	6005007	43	19	41	10	11	13	1	7	11	0	0.254	1.000	1.000
315	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(2), FUCA1(2), FUCA2(1), HEXA(1), HEXB(2), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(1), MANBA(1)	3201897	20	13	20	9	8	3	0	5	4	0	0.826	1.000	1.000
316	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(1), ENPP3(2), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(3), NT5E(1)	2582891	14	5	14	9	3	5	0	2	4	0	0.982	1.000	1.000
317	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), NFKB1(3), NFKB2(2), NFKBIE(1), PDK1(2), PHKA2(4), PIK3CB(1), PLD1(3), PLD2(3)	6926509	41	23	48	10	16	10	1	8	5	1	0.186	1.000	1.000
318	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPP(1), ENPP3(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), TYR(3)	2629931	12	10	12	7	5	3	1	1	1	1	0.931	1.000	1.000
319	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP5(1), ACPP(1), ALPPL2(1), CYP3A43(3), CYP3A7(2), DHRS2(1), PON1(1), PON2(1), PON3(4)	2870024	15	11	13	6	4	5	0	4	1	1	0.716	1.000	1.000
320	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(13), EP300(14), IKBKB(2), NFKB1(3), RELA(1), TNF(1)	3810059	38	20	36	11	10	7	2	13	6	0	0.487	1.000	1.000
321	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG5(1), BECN1(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), PIK3C3(4), PIK3R4(1), PRKAA1(1), PRKAA2(5), ULK1(2)	3471913	22	13	22	7	4	7	0	7	4	0	0.686	1.000	1.000
322	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNGT1(1), HTR2C(2), PLCB1(1), TUB(1)	1237695	6	3	6	4	1	3	0	1	1	0	0.923	1.000	1.000
323	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(1), CXCR4(1), GNAI1(2), GNAQ(1), GNGT1(1), MAP2K1(2), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3CA(56), PLCG1(2), PRKCA(3), RAF1(3), RELA(1)	4155357	79	48	71	24	12	20	1	42	4	0	0.656	1.000	1.000
324	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(1), CAD(3), CANT1(1), CDA(1), CTPS(1), DCK(1), DHODH(1), DPYD(10), DPYS(2), DTYMK(1), ENTPD1(1), ENTPD4(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(3), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1), PNPT1(5), POLA1(5), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1), PRIM2(1), RFC5(2), RRM1(1), TK2(1), TXNRD2(1), TYMS(2), UMPS(1), UPB1(2), UPP2(2), UPRT(1)	13846234	91	46	91	16	25	33	2	18	13	0	0.00980	1.000	1.000
325	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1)	1408598	7	5	7	4	2	3	0	1	1	0	0.868	1.000	1.000
326	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(1), MAN1A1(2), MGAT1(2), MGAT4A(1), MGAT4B(1), RPN2(1)	3118050	15	12	15	9	4	3	0	4	4	0	0.952	1.000	1.000
327	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTR2(1), ACTR3(1), ANGPTL2(1), CDC42(1), FLNA(7), FLNC(3), FSCN3(1), LIMK1(1), MYH2(5), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), RHO(1), ROCK1(8), ROCK2(5), RPS4X(2), WASF1(3), WASL(2)	7459583	59	29	59	16	22	14	0	12	11	0	0.234	1.000	1.000
328	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(2), EPHB2(1), GRB2(2), ITPKB(1), MAP2K1(2), MAP2K2(1), NFKB1(3), NFKB2(2), NFKBIE(1), PI3(1), PIK3CA(56), PIK3CD(1), PLCG2(5), PPP1R13B(1), RAF1(3), SERPINA4(5), SHC1(1), SOS1(5), SOS2(2), SYK(3), VAV1(2)	8208554	107	49	98	29	20	28	1	53	5	0	0.369	1.000	1.000
329	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), PLCB1(1), PRKCA(3), RELA(1)	1430443	9	5	9	7	6	2	0	0	1	0	0.956	1.000	1.000
330	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(1), CYP11A1(2), EDNRA(1), EDNRB(6), PLA2G4A(3), PRL(1), PTGDR(2), PTGFR(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2)	3533294	22	16	21	9	9	7	0	3	3	0	0.782	1.000	1.000
331	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(6), EPHB1(5), FYN(2), ITGB1(1), L1CAM(3), SELP(2)	2562900	21	16	24	9	8	7	0	3	3	0	0.789	1.000	1.000
332	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GRB2(2), INSR(1), IRS1(4), JAK2(7), MAP2K1(2), MAPK3(1), PIK3CA(56), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SLC2A4(1), SOS1(5), STAT5A(2), STAT5B(1)	5286657	92	48	83	27	13	21	1	52	4	1	0.660	1.000	1.000
333	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5), SYK(3), VAV1(2)	6377521	50	25	50	13	15	15	1	14	5	0	0.293	1.000	1.000
334	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(5), POLA2(1), POLB(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLG(1), POLH(3), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM2(1), REV1(3), REV3L(9), RFC5(2)	6894242	45	21	45	10	11	18	0	8	7	1	0.290	1.000	1.000
335	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(7), CSF1R(1), EGF(1), EGFR(11), GRB2(2), MET(7), PDGFRA(8), PRKCA(3), SH3GLB1(1)	3453045	41	21	41	14	9	9	1	20	2	0	0.702	1.000	1.000
336	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(7), ATP4A(3), ATP5A1(3), ATP5C1(3), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), COX15(3), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(2), TCIRG1(1), UQCRC2(2)	9583405	63	31	62	15	19	20	0	20	4	0	0.134	1.000	1.000
337	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(1), GNAI1(2), GNGT1(1), ITGB1(1), MAP2K1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(3), PTGS1(1), RAF1(3), SYK(3), TBXAS1(2)	4215517	24	15	24	9	8	5	0	5	6	0	0.753	1.000	1.000
338	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), APOA4(2), APOC1(1), APOC2(1), CETP(1), CYP7A1(1), HMGCR(1), LDLR(2), LIPC(1), LRP1(4), SCARB1(1)	4476099	20	9	20	7	10	5	1	2	2	0	0.557	1.000	1.000
339	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(5), C6(3), C7(1), IL6(2), IL8(1), ITGA4(6), ITGAL(3), ITGB1(1), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(3)	4164554	35	18	37	12	12	11	0	4	8	0	0.557	1.000	1.000
340	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(2), GOT1(1), PAH(2), TAT(2)	1479656	9	6	9	4	2	5	0	0	2	0	0.754	1.000	1.000
341	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(2), AGTR1(2), AGTR2(2), BDKRB2(2), KNG1(1), NOS3(2), REN(2)	1496311	15	9	15	6	4	7	0	2	2	0	0.607	1.000	1.000
342	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP3(1), CASP8(1), INSR(1), MAGI1(4), MAGI2(7), WWP1(3), WWP2(1)	3980375	20	9	20	6	6	2	1	6	5	0	0.663	1.000	1.000
343	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(7), AR(6), ESR1(1), HNF4A(4), NPM1(1), NR0B1(1), NR1D1(1), NR1D2(3), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR3C1(3), NR4A2(3), PGR(1), PPARD(1), RARA(1), RARB(2), ROR1(4), RORC(1), RXRB(1), RXRG(1), VDR(1)	6641805	48	22	47	12	15	9	0	19	5	0	0.248	1.000	1.000
344	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2A1L(4), GTF2B(1), GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(3), TAF1(6), TAF12(1), TAF1L(16), TAF2(3), TAF4(2), TAF4B(2), TAF5(2), TAF5L(1), TAF6(1), TAF7(1), TAF7L(2), TAF9(1)	6275731	52	30	50	14	14	12	1	15	10	0	0.409	1.000	1.000
345	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), ACADS(1), ACSL3(1), CPT1A(3), CPT2(1), DCI(1), EHHADH(2), HADHA(2), SLC25A20(1)	2914240	17	9	16	8	4	5	0	5	3	0	0.883	1.000	1.000
346	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(1), GOT1(1), PAH(2), TAT(2), YARS2(1)	1537082	9	5	9	4	1	7	0	0	1	0	0.790	1.000	1.000
347	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), CYP1A2(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP3A43(3), CYP3A7(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1)	4121569	26	11	26	9	12	5	1	6	2	0	0.560	1.000	1.000
348	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SLC2A4(1), YWHAH(2)	3252830	19	10	20	8	6	6	0	4	3	0	0.767	1.000	1.000
349	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(2), BDKRB2(2), CAV1(1), CHRNA1(3), FLT1(9), FLT4(2), KDR(4), NOS3(2), PDE3A(2), PDE3B(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKG1(6), PRKG2(2)	5076155	47	25	45	16	11	11	1	19	5	0	0.611	1.000	1.000
350	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT2(1), ACYP1(1), DHRS2(1), ECHS1(1), EHHADH(2), ESCO1(6), ESCO2(5), GCDH(2), HADHA(2), MYST3(6), MYST4(8), SH3GLB1(1)	4342022	36	19	34	11	6	13	0	13	4	0	0.623	1.000	1.000
351	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(8), FYN(2), ITGB1(1), MAP2K1(2), MAPK3(1), MYLK(4), PIK3CA(56), RAF1(3), ROCK1(8), SHC1(1), TLN1(2)	6212079	88	48	76	26	9	23	1	50	5	0	0.624	1.000	1.000
352	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(4), CALCRL(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(3), EMR1(4), EMR2(4), GLP1R(5), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(4), LPHN3(4), SCTR(1), VIPR1(1)	4487325	43	23	47	15	18	13	0	8	4	0	0.409	1.000	1.000
353	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(2), GPR161(3), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1)	1667795	15	8	15	6	6	3	0	3	3	0	0.585	1.000	1.000
354	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(37), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(3), FSHR(3), MLH1(6), MSH5(1), NCOR1(5), NRIP1(1), PGR(1), PRLR(2), SMPD1(1), VDR(1), ZP2(2)	5901079	69	37	67	20	13	18	3	24	9	2	0.478	1.000	1.000
355	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(4), ACTN2(4), ITGB1(1), ITGB3(4), SPTAN1(5), TLN1(2)	4678961	22	13	22	8	8	7	1	2	4	0	0.635	1.000	1.000
356	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	BRAF(14), CPEB1(3), EGFR(11), ERBB4(9), ETS1(4), ETS2(1), ETV6(1), GRB2(2), MAP2K1(2), MAPK3(1), NOTCH1(1), NOTCH2(6), NOTCH3(4), NOTCH4(5), PIWIL1(4), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(3), SOS1(5), SOS2(2), SPIRE1(2), SPIRE2(2)	7346986	91	45	88	25	15	28	2	35	11	0	0.398	1.000	1.000
357	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACOX3(2), ELOVL6(1), FADS2(2), HADHA(2)	1872007	7	7	7	6	3	3	0	0	1	0	0.957	1.000	1.000
358	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(5), AASDHPPT(1), AASS(3), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), BBOX1(2), DLST(1), DOT1L(1), ECHS1(1), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(2), HADHA(2), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(3)	5874736	41	21	39	13	10	12	1	12	6	0	0.571	1.000	1.000
359	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(37), ATR(10), BRCA1(3), BRCA2(22), CHEK1(1), CHEK2(3), FANCA(3), FANCD2(7), FANCF(1), FANCG(2), HUS1(1), MRE11A(5), RAD17(2), RAD50(7)	7639113	104	42	97	26	10	37	4	39	12	2	0.470	1.000	1.000
360	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(2), EXT2(2), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), NDST1(1), NDST2(1), NDST3(4)	3392649	24	14	24	9	7	7	1	7	2	0	0.681	1.000	1.000
361	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(4), ARHGEF2(1), ARPC5L(2), CDC42(1), CTNNB1(21), CTTN(1), FYN(2), HCLS1(1), ITGB1(1), NCK1(1), NCK2(1), NCL(2), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(5), TLR4(3), TLR5(2), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1), WASL(2)	8108982	86	40	84	24	24	26	1	26	9	0	0.302	1.000	1.000
362	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(4), ARHGEF2(1), ARPC5L(2), CDC42(1), CTNNB1(21), CTTN(1), FYN(2), HCLS1(1), ITGB1(1), NCK1(1), NCK2(1), NCL(2), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(5), TLR4(3), TLR5(2), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1), WASL(2)	8108982	86	40	84	24	24	26	1	26	9	0	0.302	1.000	1.000
363	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA3(2), CA5A(1), CA7(1), CA8(1), CPS1(8), CTH(1), GLUL(1), HAL(1)	3304266	16	7	16	6	5	6	0	3	2	0	0.701	1.000	1.000
364	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(2), GNAQ(1), GNAS(4), GNGT1(1), LIMK1(1), MAP2K1(2), MAPK3(1), PIK3C2G(2), PLCB1(1), PPP1R12B(5), PRKCA(3), RAF1(3), ROCK2(5)	4128496	32	20	33	10	8	7	2	5	10	0	0.673	1.000	1.000
365	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(4), CDC7(2), DIAPH2(4), GMNN(2), MCM10(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), NACA(5), PCNA(3), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), RFC1(5), RFC2(1), RFC5(2), RPA4(1), UBB(1), UBC(1)	8336337	52	27	49	12	11	20	0	15	6	0	0.267	1.000	1.000
366	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(3), IMPDH1(1), POLB(2), POLD1(2), POLG(1), RRM1(1)	2024182	10	7	10	5	4	2	0	3	1	0	0.850	1.000	1.000
367	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	17	AADAC(2), AOC3(1), CES1(1), CES7(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), PLA1A(2), PRDX6(1), SH3GLB1(1)	4054470	34	17	33	11	7	13	0	11	3	0	0.608	1.000	1.000
368	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ALDH1A3(2), ALDH3B2(1), AOC3(1), EPX(1), ESCO1(6), ESCO2(5), GOT1(1), HPD(1), LPO(1), MAOA(2), MAOB(3), MPO(4), MYST3(6), MYST4(8), PRDX6(1), SH3GLB1(1), TAT(2), TPO(7)	5715960	53	25	52	16	12	21	1	12	7	0	0.494	1.000	1.000
369	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), DARS(1), EPRS(4), FARS2(2), IARS(1), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1)	5674133	27	14	27	8	4	9	1	8	5	0	0.653	1.000	1.000
370	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(1), ALOX15(1), CYP4F3(1), EPX(1), GGT1(2), LPO(1), MPO(4), PLA2G4A(3), PLA2G6(2), PRDX1(1), PRDX6(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2), TPO(7)	4577993	32	21	32	10	15	7	1	2	7	0	0.503	1.000	1.000
371	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	61	AGTR1(2), AGTR2(2), ATP8A1(5), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), CCKAR(3), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(6), FPR1(3), FSHR(3), GALR1(1), GPR77(1), MC2R(3), MC3R(1), MC4R(1), MC5R(2), NMBR(1), NPY5R(2), NTSR2(1), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR4(2), TRHR(2), TSHR(4)	8121558	81	42	80	28	31	24	2	21	3	0	0.294	1.000	1.000
372	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA3(2), CA5A(1), CA7(1), CA8(1), CPS1(8), CTH(1), GLUD2(2), GLUL(1), HAL(1)	3674511	18	9	18	8	5	8	0	3	2	0	0.820	1.000	1.000
373	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), LMNA(1), NFKB1(3), RELA(1), SPTAN1(5), TNFRSF10B(4), TNFSF10(1)	5556770	39	17	37	11	13	11	0	7	8	0	0.498	1.000	1.000
374	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKB(1), CKM(1), CKMT2(4), CPS1(8), DAO(4), EPRS(4), GLUD2(2), GOT1(1), LAP3(1), NOS1(8), NOS3(2), OAT(1), OTC(3), P4HA1(1), P4HA3(2), RARS(2), RARS2(3)	5941862	53	23	53	16	16	19	2	8	8	0	0.422	1.000	1.000
375	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(4), BAX(2), BCL2L11(1), BIRC2(2), BIRC3(7), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), CHUK(4), DFFA(2), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF1(1), IRF3(2), IRF4(2), MAP2K4(4), MAP3K1(3), MAPK10(4), NFKB1(3), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), TNF(1), TNFRSF10B(4), TNFRSF21(1), TNFSF10(1), TRAF1(2), TRAF3(2)	9187505	69	30	67	18	18	23	1	13	14	0	0.304	1.000	1.000
376	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(1), CDC42(1), DAXX(4), DDIT3(1), GRB2(2), HSPB2(1), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP3K5(2), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MEF2A(2), MKNK1(2), PLA2G4A(3), RPS6KA5(3), SHC1(1), STAT1(2), TGFB2(4), TGFBR1(3)	6067967	47	22	48	14	9	15	0	17	6	0	0.504	1.000	1.000
377	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), ALDOC(2), FBP2(1), FPGT(3), GMDS(1), GMPPA(1), HK2(1), HK3(5), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB3(1), PFKM(3), PFKP(1), PGM2(1), PMM1(2), RDH11(1), RDH12(1), SORD(2)	6198694	36	19	36	11	14	13	1	7	1	0	0.351	1.000	1.000
378	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B2(1), EIF2B5(1), EIF2S3(1), FLT1(9), FLT4(2), HIF1A(2), KDR(4), NOS3(2), PIK3CA(56), PLCG1(2), PRKCA(3), SHC1(1)	5220483	85	47	74	27	13	18	2	49	3	0	0.686	1.000	1.000
379	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(37), ATR(10), BRCA1(3), CDC25C(1), CHEK1(1), CHEK2(3), EP300(14), MYT1(5), PRKDC(5), YWHAH(2)	6804657	81	42	80	23	13	21	3	31	11	2	0.568	1.000	1.000
380	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(2), CAV3(1), DAG1(2), EPHB2(1), GNAI1(2), GNAQ(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(12)	6336171	39	25	46	13	17	11	0	6	4	1	0.331	1.000	1.000
381	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNA1(1), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(2), IL1RN(1), IL6(2), IRAK3(2), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(6), MYD88(1), NFKB1(3), RELA(1), TGFB2(4), TNF(1)	4886545	42	13	42	13	12	13	2	11	4	0	0.534	1.000	1.000
382	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5)	2840034	16	9	15	6	3	5	0	5	3	0	0.731	1.000	1.000
383	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(2), CALR(1), CD8A(1), CIITA(3), CTSB(3), CTSL1(2), HLA-A(3), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(2), HSPA5(2), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), KIR2DL1(1), KIR3DL1(4), KIR3DL2(1), KIR3DL3(1), KLRC3(1), KLRC4(1), LGMN(2), NFYA(2), RFX5(1), TAP1(2), TAP2(1), TAPBP(2)	7076403	58	27	59	20	14	21	1	13	7	2	0.609	1.000	1.000
384	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), LPA(2), MAP2K4(4), MAP3K1(3), MAP3K5(2), MAPK8(6), NFKB1(3), NFKB2(2), NFKBIE(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(3), PLD2(3), RDX(3), ROCK1(8), ROCK2(5), SERPINA4(5)	8141239	65	27	65	19	21	22	1	13	8	0	0.485	1.000	1.000
385	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), ATIC(1), MTHFD1(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(2)	3110841	13	7	13	6	4	5	0	3	1	0	0.736	1.000	1.000
386	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), ATIC(1), MTHFD1(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(2)	3191546	13	7	13	6	4	5	0	3	1	0	0.741	1.000	1.000
387	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(13), CDR1(3), DGKI(4), FAU(1), IL6ST(1), PIGK(2), RPL10(1), RPL11(2), RPL19(1), RPL22(1), RPL28(1), RPL5(1), RPL6(2), RPL7(1), RPL9(1), RPS14(1), RPS16(1), RPS18(1), RPS2(1), RPS3(2), RPS4X(2), RPS6(1), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB2(2), SLC36A2(3), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1)	8506880	62	35	62	15	18	17	1	17	9	0	0.328	1.000	1.000
388	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	53	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3B2(1), AOC3(1), AOX1(3), DBH(1), DCT(5), ESCO1(6), ESCO2(5), FAH(1), GOT1(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), MYST3(6), MYST4(8), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), SH3GLB1(1), TAT(2), TPO(7), TYR(3)	9718308	79	35	77	26	13	29	2	21	14	0	0.622	1.000	1.000
389	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(2), FLOT1(1), GRB2(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(8), ITPR3(5), MAP4K1(1), MAPK3(1), NFATC1(2), NFATC2(2), PDK1(2), PIK3CA(56), PIK3CD(1), PLCG2(5), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTPRC(9), RAF1(3), SHC1(1), SOS1(5), SOS2(2), SYK(3), VAV1(2)	11479238	135	58	133	34	29	41	1	52	11	1	0.166	1.000	1.000
390	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(3), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), BBOX1(2), DLST(1), DOT1L(1), ECHS1(1), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(2), HADHA(2), HSD17B10(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(2), SETDB1(1), SHMT1(1), SPCS1(1), SUV39H2(1), TMLHE(3)	9471424	56	24	54	17	18	16	1	12	9	0	0.469	1.000	1.000
391	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(3), CANT1(1), CDA(1), CTPS(1), DCK(1), DHODH(1), DPYD(10), DPYS(2), DTYMK(1), ENTPD1(1), NT5E(1), POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1), RRM1(1), TK2(1), TYMS(2), UMPS(1), UPB1(2)	9563213	56	31	55	16	13	18	2	15	8	0	0.385	1.000	1.000
392	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(4), AMY1B(1), AMY2A(2), AMY2B(3), ENPP3(2), G6PC(1), GANAB(1), GCK(3), GPI(1), GYS1(1), GYS2(4), HK2(1), HK3(5), PGM1(2), PGM3(2), PYGL(2), PYGM(2), SI(4), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1)	9780094	52	28	51	16	15	14	0	14	9	0	0.513	1.000	1.000
393	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(3), IL1R1(1), MAP2K4(4), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(6), MAPK9(3), NFATC3(2), PAPPA(6), SHC1(1), ZAK(4)	8191185	65	35	64	20	19	18	2	14	12	0	0.505	1.000	1.000
394	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH4A1(1), AMD1(1), AOC3(1), ARG2(1), ASL(2), CKB(1), CKM(1), CKMT2(4), CPS1(8), DAO(4), GOT1(1), MAOA(2), MAOB(3), NOS1(8), NOS3(2), OAT(1), ODC1(3), OTC(3), P4HA1(1), P4HA3(2), RARS(2)	7366444	63	26	62	21	22	18	3	9	11	0	0.465	1.000	1.000
395	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	83	ACVR1(3), ACVR1B(3), ACVR1C(2), ACVR2A(2), ACVR2B(2), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP6(2), BMP7(1), BMPR1B(1), BMPR2(3), CHRD(2), CREBBP(13), CUL1(1), DCN(2), EP300(14), FST(1), GDF5(2), GDF6(1), INHBA(4), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL1(3), RBL2(2), RBX1(1), RHOA(1), ROCK1(8), ROCK2(5), RPS6KB2(2), SMAD3(5), SMAD5(1), SMAD7(1), SMAD9(2), SMURF1(2), SMURF2(1), SP1(1), TGFB2(4), TGFBR1(3), TGFBR2(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNF(1), ZFYVE16(3), ZFYVE9(5)	16085937	143	56	141	30	41	39	2	37	23	1	0.0198	1.000	1.000
396	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX23(4), DDX4(3), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(2), EP400(4), ERCC3(1), GGH(1), IFIH1(2), MOV10L1(7), RAD54B(2), RUVBL2(2), SETX(10), SKIV2L2(2), SMARCA2(3), SMARCA5(5)	10438511	61	25	61	18	17	17	1	13	13	0	0.452	1.000	1.000
397	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(3), ACOX2(1), ACOX3(2), ACSL3(1), ACSL5(1), ACSL6(1), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), CYP4A11(1), CYP7A1(1), CYP8B1(1), EHHADH(2), FABP2(1), FABP7(1), FADS2(2), GK2(3), HMGCS2(1), ME1(3), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(4), UBC(1)	11056050	57	25	56	18	23	17	1	11	5	0	0.407	1.000	1.000
398	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTN1(4), ACTN2(4), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(8), BCAR1(1), BIRC2(2), BIRC3(7), BRAF(14), CAPN2(2), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(9), COL11A2(2), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), CTNNB1(21), DOCK1(2), EGF(1), EGFR(11), FARP2(1), FIGF(2), FLNA(7), FLNB(4), FLNC(3), FLT1(9), FN1(6), FYN(2), GRB2(2), GRLF1(1), GSK3B(1), HGF(4), IGF1R(5), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAV(4), ITGB1(1), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), KDR(4), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), MAP2K1(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), MET(7), MYL9(3), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(1), PGF(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(5), PTEN(47), RAF1(3), RAP1A(1), RELN(12), RHOA(1), ROCK1(8), ROCK2(5), SHC1(1), SOS1(5), SOS2(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TLN1(2), TLN2(4), TNC(3), TNN(3), TNR(3), VAV1(2), VAV2(2), VAV3(3), VCL(1), VEGFC(4), VTN(3), VWF(6), ZYX(3)	58725301	569	95	558	221	141	169	10	194	55	0	0.970	1.000	1.000
399	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	162	ADCY1(5), ADCY2(7), ADCY3(1), ADCY7(3), ADCY8(4), ADCY9(3), ADORA2A(3), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(4), ATP2B4(5), AVPR1A(2), BDKRB1(1), BDKRB2(2), BST1(1), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1F(2), CACNA1G(1), CACNA1I(4), CACNA1S(5), CAMK2D(1), CAMK4(3), CCKAR(3), CCKBR(4), CD38(1), CHRM2(4), CHRM3(2), CHRM5(1), CHRNA7(1), CYSLTR2(2), EDNRA(1), EDNRB(6), EGFR(11), ERBB3(4), ERBB4(9), GNA14(3), GNA15(1), GNAL(1), GNAQ(1), GNAS(4), GRIN2A(7), GRIN2C(2), GRIN2D(3), GRM1(5), GRM5(5), HRH2(1), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), OXTR(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(1), PDE1C(2), PDGFRA(8), PDGFRB(1), PHKA1(5), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PTGER3(1), PTGFR(1), RYR1(12), RYR3(2), SLC25A5(2), SLC8A1(2), SLC8A2(2), SLC8A3(4), SPHK1(1), TRHR(2), TRPC1(2)	40006425	314	94	349	115	114	90	9	70	29	2	0.537	1.000	1.000
400	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	222	ADCYAP1R1(1), ADORA1(4), ADORA2A(3), ADORA3(1), ADRA1A(2), ADRA1B(1), ADRA2B(1), ADRB1(2), ADRB3(2), AGTR1(2), AGTR2(2), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(2), CCKAR(3), CCKBR(4), CGA(1), CHRM2(4), CHRM3(2), CHRM5(1), CNR1(3), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR2(2), DRD2(2), DRD3(1), DRD5(4), EDNRA(1), EDNRB(6), F2(1), F2RL1(1), F2RL2(2), FPR1(3), FSHB(2), FSHR(3), GABBR1(4), GABBR2(8), GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GABRB1(1), GABRB2(3), GABRB3(5), GABRE(2), GABRG1(4), GABRG2(5), GABRG3(1), GABRP(4), GABRQ(3), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(3), GPR83(1), GRIA1(3), GRIA2(6), GRIA3(4), GRIA4(10), GRID1(2), GRID2(3), GRIK2(6), GRIK3(5), GRIK4(1), GRIK5(1), GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), GRIN3A(3), GRM1(5), GRM2(3), GRM3(4), GRM5(5), GRM6(3), GRM7(6), GRM8(2), GZMA(3), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), LEPR(6), LTB4R(1), MAS1(1), MC2R(3), MC3R(1), MC4R(1), MC5R(2), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(4), NMBR(1), NMUR2(3), NPBWR1(2), NPFFR2(1), NPY5R(2), NR3C1(3), NTSR2(1), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(3), P2RY14(2), P2RY2(2), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PRSS1(1), PTGDR(2), PTGER3(1), PTGFR(1), PTH2R(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(1), SSTR2(2), SSTR4(2), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(3), TAAR8(1), TRHR(2), TRPV1(2), TSHB(1), TSHR(4), VIPR1(1)	35175778	376	90	373	134	138	119	7	79	32	1	0.240	1.000	1.000
401	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	238	ACVR1B(3), ACVR1C(2), AKT2(1), AKT3(1), ATF2(1), ATF4(2), BDNF(1), BRAF(14), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1F(2), CACNA1G(1), CACNA1I(4), CACNA1S(5), CACNA2D1(3), CACNA2D3(3), CACNA2D4(1), CACNB2(2), CACNB3(1), CACNB4(1), CACNG2(1), CACNG3(4), CACNG5(1), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(4), DAXX(4), DDIT3(1), DUSP1(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(2), ECSIT(1), EGF(1), EGFR(11), ELK4(1), FAS(2), FGF11(1), FGF12(2), FGF13(2), FGF14(2), FGF19(1), FGF20(1), FGF23(1), FGF5(3), FGF8(1), FGFR1(2), FGFR2(11), FGFR3(1), FGFR4(1), FLNA(7), FLNB(4), FLNC(3), FOS(1), GNA12(1), GRB2(2), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K5(2), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(3), MAP4K4(1), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MAPKAPK2(1), MAPKAPK5(1), MAPT(1), MKNK1(2), MKNK2(1), MOS(2), NF1(20), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NTRK1(1), NTRK2(2), PAK1(1), PAK2(1), PDGFB(1), PDGFRA(8), PDGFRB(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPM1A(1), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PPP5C(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PTPN5(1), PTPN7(1), PTPRR(5), RAF1(3), RAP1A(1), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(1), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), RPS6KA5(3), RPS6KA6(3), RRAS2(3), SOS1(5), SOS2(2), STK4(1), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), TGFBR2(2), TNF(1), ZAK(4)	44266100	376	89	402	122	114	87	10	119	43	3	0.369	1.000	1.000
402	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	132	AXIN1(2), AXIN2(3), BTRC(4), CACYBP(1), CAMK2D(1), CER1(2), CHD8(2), CREBBP(13), CSNK1A1L(1), CTBP2(1), CTNNB1(21), CUL1(1), DAAM1(2), DAAM2(5), DKK1(1), DKK2(3), DKK4(3), DVL2(1), DVL3(2), EP300(14), FBXW11(1), FZD1(2), FZD10(2), FZD3(3), FZD4(1), FZD6(5), FZD7(1), FZD9(1), GSK3B(1), LRP6(10), MAP3K7(2), MAPK10(4), MAPK8(6), MAPK9(3), MMP7(2), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRICKLE1(6), PRICKLE2(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PSEN1(1), RBX1(1), RHOA(1), ROCK1(8), ROCK2(5), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(4), SMAD3(5), TBL1X(1), TCF7(3), TCF7L1(1), VANGL1(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1)	23222739	225	85	220	57	65	66	3	61	30	0	0.0341	1.000	1.000
403	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	195	ABI2(2), ACTN1(4), ACTN2(4), ACTN4(1), ARHGEF1(2), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARHGEF7(2), ARPC2(1), ARPC5L(2), BAIAP2(1), BCAR1(1), BDKRB1(1), BDKRB2(2), BRAF(14), CDC42(1), CHRM2(4), CHRM3(2), CHRM5(1), CSK(2), CYFIP1(1), DIAPH2(4), DIAPH3(2), DOCK1(2), EGF(1), EGFR(11), F2(1), FGD1(3), FGD3(1), FGF11(1), FGF12(2), FGF13(2), FGF14(2), FGF19(1), FGF20(1), FGF23(1), FGF5(3), FGF8(1), FGFR1(2), FGFR2(11), FGFR3(1), FGFR4(1), FN1(6), GIT1(1), GNA12(1), GRLF1(1), IQGAP1(7), IQGAP2(7), IQGAP3(1), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(2), ITGB1(1), ITGB2(2), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), LIMK1(1), LIMK2(2), MAP2K1(2), MAP2K2(1), MAPK3(1), MOS(2), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(3), MYLK(4), MYLK2(1), NCKAP1(2), NCKAP1L(4), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDGFB(1), PDGFRA(8), PDGFRB(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PIP5K1B(1), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), RAF1(3), RDX(3), RHOA(1), ROCK1(8), ROCK2(5), RRAS2(3), SLC9A1(3), SOS1(5), SOS2(2), SSH1(2), SSH3(1), TIAM1(8), TIAM2(2), VAV1(2), VAV2(2), VAV3(3), VCL(1), WASF1(3), WASL(2)	43783580	382	84	378	131	87	116	9	116	54	0	0.822	1.000	1.000
404	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(4), ABLIM1(3), ABLIM3(2), ARHGEF12(2), CDC42(1), CDK5(1), CXCR4(1), DCC(6), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(2), EPHA1(4), EPHA3(9), EPHA4(6), EPHA5(8), EPHA6(3), EPHA7(7), EPHA8(3), EPHB1(5), EPHB2(1), EPHB4(4), EPHB6(3), FES(1), FYN(2), GNAI1(2), GSK3B(1), ITGB1(1), L1CAM(3), LIMK1(1), LIMK2(2), LRRC4C(3), MAPK3(1), MET(7), NCK1(1), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NGEF(2), NRP1(1), NTN1(1), NTN4(3), NTNG1(3), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PLXNA1(2), PLXNA2(5), PLXNA3(2), PLXNB1(2), PLXNB3(3), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), RASA1(4), RGS3(3), RHOA(1), ROBO1(2), ROBO2(6), ROBO3(2), ROCK1(8), ROCK2(5), SEMA3A(4), SEMA3C(1), SEMA3D(7), SEMA3E(5), SEMA3F(1), SEMA3G(2), SEMA4A(1), SEMA4B(2), SEMA4D(1), SEMA4F(5), SEMA4G(2), SEMA5A(2), SEMA5B(4), SEMA6A(1), SEMA6B(2), SEMA6C(2), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(4), SLIT3(2), SRGAP1(2), SRGAP3(2), UNC5A(3), UNC5B(2), UNC5C(4), UNC5D(1)	29928239	259	83	270	73	98	65	3	60	33	0	0.0918	1.000	1.000
405	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	104	ACTN1(4), ACTN2(4), ACTN4(1), ARHGAP5(8), BCAR1(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), CXCR4(1), CYBB(2), GNAI1(2), GRLF1(1), ITGA4(6), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), ITK(5), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(6), MMP9(5), MSN(3), MYL9(3), NCF2(2), NCF4(1), NOX3(3), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLCG1(2), PLCG2(5), PRKCA(3), PRKCG(5), PTPN11(10), RAP1A(1), RAPGEF3(2), RHOA(1), RHOH(1), ROCK1(8), ROCK2(5), SIPA1(1), TXK(2), VAV1(2), VAV2(2), VAV3(3), VCAM1(3), VCL(1)	19711790	233	83	224	76	54	71	1	91	16	0	0.690	1.000	1.000
406	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(4), ABL2(3), AKT2(1), AKT3(1), BRAF(14), CAMK2D(1), CBL(7), CBLB(3), CDKN1B(2), EGF(1), EGFR(11), ERBB3(4), ERBB4(9), GRB2(2), GSK3B(1), MAP2K1(2), MAP2K2(1), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), NCK1(1), NCK2(1), NRG1(7), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLCG1(2), PLCG2(5), PRKCA(3), PRKCG(5), RAF1(3), RPS6KB2(2), SHC1(1), SOS1(5), SOS2(2), STAT5A(2), STAT5B(1)	16373845	212	79	199	68	41	54	4	94	19	0	0.732	1.000	1.000
407	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTN1(4), ACTN2(4), ACTN4(1), AKT2(1), AKT3(1), ASH1L(13), CASK(2), CDC42(1), CDK4(1), CGN(3), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), CTTN(1), EPB41L1(1), EPB41L3(4), EXOC4(3), GNAI1(2), HCLS1(1), IGSF5(2), INADL(3), LLGL1(1), LLGL2(2), MAGI1(4), MAGI2(7), MAGI3(2), MLLT4(4), MPDZ(3), MPP5(1), MYH1(9), MYH10(2), MYH11(9), MYH13(2), MYH14(3), MYH15(6), MYH2(5), MYH3(7), MYH4(2), MYH6(7), MYH7(4), MYH7B(4), MYH8(5), MYH9(3), MYL9(3), PARD3(2), PARD6A(1), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PTEN(47), RHOA(1), RRAS2(3), SPTAN1(5), TJAP1(2), TJP1(4), TJP3(1), YES1(1), ZAK(4)	31490033	273	79	277	102	72	84	2	83	31	1	0.945	1.000	1.000
408	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CDS1(2), CDS2(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), IMPA2(1), INPP1(1), INPP4B(3), INPP5D(2), INPPL1(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), OCRL(5), PI4KA(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3C3(4), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PIP5K1B(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PRKCA(3), PRKCG(5), PTEN(47), PTPMT1(2), SYNJ1(4), SYNJ2(1)	19675115	227	77	224	77	45	67	4	93	17	1	0.863	1.000	1.000
409	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(3), ACVR1B(3), ACVRL1(1), BMPR2(3), BUB1(3), CDKL1(3), CDS1(2), CDS2(1), CLK1(2), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), MAP3K10(1), MOS(2), NEK3(1), OCRL(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3CA(56), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG1(2), PLCG2(5), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), PRKG1(6), RAF1(3), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), TGFBR1(3), VRK1(1)	18404608	193	76	185	60	41	53	1	78	20	0	0.707	1.000	1.000
410	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), ATP1A4(3), ATP1B2(2), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(4), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1S(5), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(4), CHRM3(2), CHRM5(1), GJA1(4), GJB3(1), GJB4(1), GNAQ(1), GNAZ(2), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNB1(3), KCNJ5(1), MIB1(5), MYCBP(1), NME7(3), PKIA(2), PLCB3(1), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RGS17(1), RGS2(2), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(2), RGS9(3), RYR1(12), RYR3(2), SLC8A1(2), SLC8A3(4), USP5(1), YWHAH(2)	28236583	198	75	234	73	76	64	1	30	26	1	0.477	1.000	1.000
411	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	133	CHAD(1), COL11A1(9), COL11A2(2), COL17A1(3), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), DES(1), DSC1(2), DSC2(1), DSC3(1), DSG1(4), DSG2(1), DSG4(5), FN1(6), GJA1(4), GJA10(5), GJA3(1), GJA8(3), GJA9(1), GJB3(1), GJB4(1), GJB7(1), GJC1(1), GJC3(1), GJD2(1), INA(1), ITGA6(2), ITGB4(2), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT17(1), KRT2(1), KRT20(1), KRT24(3), KRT27(1), KRT3(3), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT5(1), KRT6A(1), KRT6C(1), KRT7(2), KRT73(4), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT81(1), KRT82(2), KRT83(1), KRT84(4), KRT85(3), KRT9(1), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), LMNA(1), LMNB1(2), LMNB2(1), NES(2), PRPH(1), RELN(12), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNC(3), TNN(3), TNR(3), VIM(2), VTN(3), VWF(6)	39426880	267	74	272	128	107	85	3	43	29	0	0.994	1.000	1.000
412	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	122	ACACA(6), ACACB(3), AKT2(1), AKT3(1), BRAF(14), CBL(7), CBLB(3), EXOC7(1), FBP2(1), FLOT1(1), G6PC(1), G6PC2(1), GCK(3), GRB2(2), GSK3B(1), GYS1(1), GYS2(4), IKBKB(2), INPP5D(2), INSR(1), IRS1(4), IRS4(6), LIPE(2), MAP2K1(2), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), MKNK1(2), MKNK2(1), PCK1(3), PDE3A(2), PDE3B(2), PFKM(3), PFKP(1), PHKA1(5), PHKA2(4), PHKB(2), PHKG2(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PKLR(1), PPP1CB(1), PPP1CC(1), PPP1R3A(7), PPP1R3C(2), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCI(1), PRKCZ(1), PTPN1(1), PTPRF(2), PYGL(2), PYGM(2), RAF1(3), RHEB(1), RPS6(1), RPS6KB2(2), SHC1(1), SLC2A4(1), SOCS2(2), SOCS4(1), SORBS1(4), SOS1(5), SOS2(2), TRIP10(1), TSC1(1), TSC2(2)	24853456	249	73	237	77	62	63	5	95	24	0	0.431	1.000	1.000
413	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	91	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ATF4(2), CACNA1C(3), CACNA1D(1), CACNA1F(2), CACNA1S(5), CAMK2D(1), CDC42(1), CGA(1), EGFR(11), FSHB(2), GNAQ(1), GNAS(4), GNRH2(1), GRB2(2), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MMP14(1), MMP2(6), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(3), PLD2(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), RAF1(3), SOS1(5), SOS2(2)	20627528	160	73	168	56	53	37	6	39	24	1	0.558	1.000	1.000
414	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ABL1(4), ACTN1(4), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(3), ARHGEF7(2), BCAR1(1), BRAF(14), CAV1(1), CDC42(1), CDKN2A(2), DOCK1(2), EPHB2(1), FYN(2), GRB2(2), GRLF1(1), ITGA10(4), ITGA2(1), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGB3BP(2), MAP2K4(4), MAP2K7(2), MAP3K11(1), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PIK3CA(56), PIK3CB(1), PKLR(1), PLCG1(2), PLCG2(5), PTEN(47), RAF1(3), RALA(1), RHO(1), ROCK1(8), ROCK2(5), SHC1(1), SOS1(5), SOS2(2), TERF2IP(1), TLN1(2), TLN2(4), ZYX(3)	19965070	258	73	251	100	45	75	6	106	26	0	0.983	1.000	1.000
415	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	154	ADORA1(4), ADORA2A(3), ADORA3(1), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), AGTR1(2), AGTR2(2), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(3), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(4), CHRM2(4), CHRM3(2), CHRM5(1), CMKLR1(3), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD2(2), DRD3(1), DRD5(4), EDNRA(1), EDNRB(6), F2RL1(1), F2RL2(2), FPR1(3), FSHR(3), GALR1(1), GPR17(1), GPR174(2), GPR37(3), GPR4(1), GPR6(1), GPR63(3), GPR77(1), GPR83(1), GPR85(1), GPR87(1), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), LTB4R(1), MAS1(1), MC3R(1), MC4R(1), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(4), NMBR(1), NMUR2(3), NPY5R(2), NTSR2(1), OPN3(1), OPRK1(2), OPRL1(1), OPRM1(3), OR12D3(3), OR1C1(2), OR1Q1(1), OR2H1(2), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(3), P2RY12(1), P2RY14(2), P2RY2(2), P2RY6(1), PPYR1(3), PTGDR(2), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(2), SSTR4(2), SUCNR1(3), TRHR(2)	18913775	208	72	208	63	75	75	3	43	12	0	0.0161	1.000	1.000
416	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	BRAF(14), CASP3(1), FAS(2), FCGR3A(1), FYN(2), GRB2(2), GZMB(1), HLA-A(3), HLA-G(1), ICAM2(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(4), KIR3DL2(1), KLRC3(1), KLRK1(1), LAT(1), LCK(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MICB(3), NCR1(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PAK1(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLCG1(2), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRF1(1), PRKCA(3), PRKCG(5), PTPN11(10), RAF1(3), SH3BP2(1), SHC1(1), SOS1(5), SOS2(2), SYK(3), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP3(1), VAV1(2), VAV2(2), VAV3(3)	18071513	199	72	187	72	43	52	3	84	17	0	0.866	1.000	1.000
417	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	CD44(1), CHAD(1), COL11A1(9), COL11A2(2), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), DAG1(2), FN1(6), FNDC1(7), FNDC3A(2), GP5(1), GP6(2), HMMR(2), HSPG2(1), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAV(4), ITGB1(1), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), RELN(12), SDC1(2), SDC2(1), SDC3(2), SV2A(2), SV2B(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNC(3), TNN(3), TNR(3), VTN(3), VWF(6)	35452440	239	71	250	107	83	73	6	46	31	0	0.974	1.000	1.000
418	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	134	ACTA1(2), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ATF1(1), ATF2(1), ATF4(2), ATP2A2(1), ATP2A3(2), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(2), DGKZ(1), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GJA1(4), GNAQ(1), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), GSTO1(1), GUCY1A3(8), IGFBP3(2), IL1B(1), IL6(2), ITPR1(2), ITPR2(8), ITPR3(5), MIB1(5), MYL4(1), MYLK2(1), NFKB1(3), NOS1(8), NOS3(2), OXTR(1), PDE4B(4), PDE4D(2), PKIA(2), PLCB3(1), PLCD1(1), PLCG1(2), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(12), RYR3(2), SLC8A1(2), SP1(1), USP5(1), YWHAH(2)	25213055	189	71	208	60	69	67	2	24	26	1	0.175	1.000	1.000
419	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADRB1(2), CSNK1D(1), DRD2(2), EGF(1), EGFR(11), GJA1(4), GJD2(1), GNAI1(2), GNAQ(1), GNAS(4), GRB2(2), GRM1(5), GRM5(5), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(5), HTR2C(2), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR1(2), NPR2(2), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PRKG1(6), PRKG2(2), RAF1(3), SOS1(5), SOS2(2), TJP1(4), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1)	21296221	197	70	204	58	61	58	6	52	18	2	0.144	1.000	1.000
420	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	143	AKT2(1), AKT3(1), CBL(7), CBLB(3), CREBBP(13), CSF3(1), CSF3R(1), EP300(14), GH1(1), GH2(2), GRB2(2), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), IFNK(2), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(5), IL13RA1(1), IL13RA2(2), IL19(1), IL2(1), IL20(1), IL20RA(2), IL21R(3), IL23R(1), IL28A(1), IL2RA(3), IL2RB(1), IL2RG(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(2), JAK2(7), JAK3(4), LEPR(6), LIFR(6), MPL(4), OSMR(2), PIAS2(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PIM1(1), PRL(1), PRLR(2), PTPN11(10), SOCS2(2), SOCS4(1), SOCS5(2), SOS1(5), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT1(2), STAT2(2), STAT4(3), STAT5A(2), STAT5B(1), TPO(7)	23700297	239	70	228	87	41	74	5	89	28	2	0.951	1.000	1.000
421	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	240	ACVR1(3), ACVR1B(3), ACVR2A(2), ACVR2B(2), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL11(1), CCL18(1), CCL22(1), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR3(1), CXCR4(1), EDA(3), EDAR(2), EGF(1), EGFR(11), FAS(2), FLT1(9), FLT3(9), FLT4(2), GDF5(2), GH1(1), GH2(2), HGF(4), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), IFNK(2), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(5), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(3), IL18RAP(2), IL19(1), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(1), IL20(1), IL20RA(2), IL21R(3), IL23R(1), IL28A(1), IL2RA(3), IL2RB(1), IL2RG(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(4), INHBC(1), INHBE(1), KDR(4), KIT(22), LEPR(6), LIFR(6), LTBR(1), MET(7), MPL(4), NGFR(1), OSMR(2), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TGFBR2(2), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF11B(2), TNFRSF13B(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF10(1), TNFSF13B(1), TNFSF14(1), TNFSF4(2), TNFSF8(2), TPO(7), VEGFC(4), XCL2(1), XCR1(1)	29424144	266	69	261	86	56	84	4	84	37	1	0.557	1.000	1.000
422	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	123	ALCAM(1), CADM1(3), CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD6(1), CD80(2), CD8A(1), CDH15(1), CDH2(7), CDH3(2), CDH4(5), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(6), CTLA4(1), GLG1(2), HLA-A(3), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-F(1), HLA-G(1), ICAM2(1), ICOSLG(1), ITGA4(6), ITGA6(2), ITGA8(4), ITGA9(4), ITGAL(3), ITGAM(1), ITGAV(4), ITGB1(1), ITGB2(2), ITGB7(3), ITGB8(3), L1CAM(3), MAG(2), NCAM1(2), NCAM2(8), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(4), NRXN1(5), NRXN2(3), NRXN3(2), PTPRC(9), PTPRF(2), PTPRM(10), PVR(1), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(2), SDC2(1), SDC3(2), SELE(2), SELP(2), SELPLG(3), SIGLEC1(2), SPN(2), VCAM1(3), VCAN(14)	23190754	207	69	212	70	63	72	3	38	31	0	0.455	1.000	1.000
423	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(5), ADCY8(4), ATF4(2), BRAF(14), CACNA1C(3), CAMK2D(1), CAMK4(3), CREBBP(13), EP300(14), GNAQ(1), GRIA1(3), GRIA2(6), GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), GRM1(5), GRM5(5), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAP2K2(1), MAPK3(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(3), RAP1A(1), RAPGEF3(2), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3)	16124520	155	69	158	46	43	41	4	47	18	2	0.268	1.000	1.000
424	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	93	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), CAMK2D(1), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(21), DCT(5), DVL2(1), DVL3(2), EDNRB(6), EP300(14), FZD1(2), FZD10(2), FZD3(3), FZD4(1), FZD6(5), FZD7(1), FZD9(1), GNAI1(2), GNAQ(1), GNAS(4), GSK3B(1), KIT(22), MAP2K1(2), MAP2K2(1), MAPK3(1), MITF(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(3), TCF7(3), TCF7L1(1), TYR(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1)	16787455	188	69	181	66	46	52	6	64	20	0	0.688	1.000	1.000
425	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTN2(4), ACTN4(1), DES(1), DMD(13), FAM48A(4), MYBPC1(3), MYBPC3(1), MYH3(7), MYH6(7), MYH7(4), MYH8(5), MYL1(1), MYL4(1), MYL9(3), MYOM1(8), NEB(8), TMOD1(1), TNNI3(1), TPM2(1), TPM3(1), TPM4(1), TTN(155), VIM(2)	17925243	235	69	246	59	62	93	1	63	15	1	0.0784	1.000	1.000
426	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT2(1), AKT3(1), CARD11(9), CBL(7), CBLB(3), CD28(1), CD3D(1), CD3G(1), CD8A(1), CDC42(1), CDK4(1), CHUK(4), CTLA4(1), FOS(1), FYN(2), GRAP2(4), GRB2(2), IKBKB(2), IL10(1), IL2(1), ITK(5), LAT(1), LCK(1), LCP2(1), MALT1(1), NCK1(1), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), NFKB2(2), NFKBIE(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDK1(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCQ(1), PTPRC(9), RASGRP1(1), RHOA(1), SOS1(5), SOS2(2), TEC(2), TNF(1), VAV1(2), VAV2(2), VAV3(3)	16249523	187	67	181	55	48	56	1	70	12	0	0.418	1.000	1.000
427	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT2(1), AKT3(1), CASP8(1), CD40(1), CD80(2), CHUK(4), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(2), IL8(1), IRAK4(2), IRF3(2), LBP(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), RELA(1), STAT1(2), TBK1(1), TLR1(3), TLR2(5), TLR3(2), TLR4(3), TLR5(2), TLR6(2), TLR7(3), TLR8(9), TLR9(4), TNF(1), TRAF3(2)	14385222	178	66	169	52	36	55	4	67	15	1	0.398	1.000	1.000
428	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(2), GAB2(1), GRB2(2), INPP5D(2), LAT(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MS4A2(3), PDK1(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(2), PLCG2(5), PRKCA(3), PRKCE(2), RAF1(3), SOS1(5), SOS2(2), SYK(3), TNF(1), VAV1(2), VAV2(2), VAV3(3)	11311743	155	66	147	45	32	39	4	65	15	0	0.470	1.000	1.000
429	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(1), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADSS(3), AK1(1), AK5(3), AK7(1), ALLC(2), AMPD1(3), AMPD2(1), AMPD3(1), ATIC(1), CANT1(1), DCK(1), ENPP3(2), ENTPD1(1), ENTPD4(1), ENTPD5(1), ENTPD6(1), GDA(1), GMPR(1), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(4), NME6(1), NME7(3), NPR1(2), NPR2(2), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1), PAPSS1(1), PAPSS2(2), PDE10A(7), PDE11A(3), PDE1A(2), PDE1C(2), PDE3B(2), PDE4B(4), PDE4D(2), PDE5A(4), PDE7A(1), PDE7B(2), PDE8B(3), PDE9A(1), PFAS(1), PKLR(1), PNPT1(5), POLA1(5), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1), PPAT(3), PRIM2(1), PRPS1(1), PRPS1L1(1), PRUNE(1), RFC5(2), RRM1(1)	27551646	183	65	185	48	60	67	2	29	25	0	0.0586	1.000	1.000
430	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CDKN2A(2), CREB3(1), CREB5(3), EBP(1), ERBB4(9), F2RL2(2), GRB2(2), GSK3B(1), INPPL1(2), IRS1(4), IRS4(6), MET(7), NOLC1(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(56), PIK3CD(1), PPP1R13B(1), PREX1(5), PTEN(47), PTPN1(1), RPS6KA2(3), RPS6KA3(3), SHC1(1), SLC2A4(1), SOS1(5), SOS2(2), TSC1(1), TSC2(2), YWHAH(2)	12385409	194	65	184	73	28	59	2	87	18	0	0.955	1.000	1.000
431	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	64	AKT2(1), AKT3(1), CASP9(1), CDC42(1), KDR(4), MAP2K1(2), MAP2K2(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NOS3(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(2), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCA(3), PRKCG(5), PTGS2(1), RAF1(3), SH2D2A(1), SPHK1(1)	10948577	126	63	116	43	34	27	2	54	9	0	0.736	1.000	1.000
432	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(4), ANAPC1(1), ANAPC4(4), ANAPC5(1), ATM(37), ATR(10), BUB1(3), BUB1B(3), CCNA1(2), CCNB3(7), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC25C(1), CDC27(5), CDC6(4), CDC7(2), CDK4(1), CDKN1B(2), CDKN2A(2), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(1), DBF4(3), E2F3(1), EP300(14), ESPL1(1), FZR1(1), GSK3B(1), MAD1L1(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), PCNA(3), PLK1(4), PRKDC(5), RB1(16), RBL1(3), RBL2(2), RBX1(1), SMAD3(5), SMC1B(3), TGFB2(4), YWHAH(2)	22285221	195	62	188	72	36	55	5	71	26	2	0.951	1.000	1.000
433	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(2), AKT2(1), AKT3(1), APAF1(4), ATM(37), BAX(2), BIRC2(2), BIRC3(7), CAPN2(2), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(2), IRAK3(2), IRAK4(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RELA(1), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(1)	13396922	180	62	167	50	32	53	3	72	18	2	0.401	1.000	1.000
434	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	BRAF(14), CACNA1A(1), CRHR1(2), GNA12(1), GNAI1(2), GNAQ(1), GNAS(4), GNAZ(2), GRIA1(3), GRIA2(6), GRIA3(4), GRID2(3), GRM1(5), GRM5(5), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(5), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAP2K2(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(2), NPR2(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(3), PRKCG(5), PRKG1(6), PRKG2(2), RAF1(3), RYR1(12)	17840385	164	62	175	54	53	45	6	46	13	1	0.428	1.000	1.000
435	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF11(4), BTK(1), CDC42(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(5), LIMK1(1), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3CG(5), PPP1R13B(1), PTEN(47), RHO(1), ROCK1(8), ROCK2(5), RPS4X(2), WASF1(3), WASL(2)	11084833	179	62	176	57	30	50	1	76	21	1	0.780	1.000	1.000
436	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(4), ATM(37), BUB1(3), BUB1B(3), CCNA1(2), CCNB3(7), CCNE2(1), CDAN1(2), CDC14A(4), CDC14B(1), CDC25C(1), CDC6(4), CDC7(2), CDK4(1), CDKN2A(2), CHEK1(1), CHEK2(3), E2F3(1), E2F6(3), EP300(14), ESPL1(1), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), MPEG1(2), MPL(4), PCNA(3), PLK1(4), PRKDC(5), PTPRA(1), RB1(16), RBL1(3)	17757159	151	61	145	53	31	41	3	60	14	2	0.842	1.000	1.000
437	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), AKAP10(1), AKAP11(4), AKAP12(6), AKAP3(4), AKAP4(2), AKAP5(1), AKAP6(7), AKAP7(1), AKAP8(1), AKAP9(9), ARHGEF1(2), GNA12(1), GNA14(3), GNA15(1), GNAL(1), GNAQ(1), GNAZ(2), GNG3(1), GNG4(1), GNGT1(1), IL18BP(3), ITPR1(2), PDE1A(2), PDE1B(1), PDE1C(2), PDE4B(4), PDE4D(2), PDE7A(1), PDE7B(2), PDE8B(3), PLCB3(1), PPP3CA(2), PPP3CC(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PRKD1(6), PRKD3(4), RHOA(1), SLC9A1(3), USP5(1)	19224996	143	61	149	43	46	45	1	27	23	1	0.263	1.000	1.000
438	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	ATF1(1), BRAF(14), CREB3(1), CREB5(3), CREBBP(13), DAG1(2), EGR1(3), EGR2(2), FRS2(2), GNAQ(1), MAP1B(13), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), NTRK1(1), OPN1LW(1), PIK3C2G(2), PIK3CA(56), PIK3CD(1), PTPN11(10), RPS6KA3(3), SHC1(1), TERF2IP(1)	7653492	153	61	140	50	25	43	6	65	14	0	0.618	1.000	1.000
439	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(4), ATM(37), ATR(10), BAI1(2), BAX(2), CASP3(1), CASP8(1), CASP9(1), CCNB3(7), CCNE2(1), CCNG1(1), CDK4(1), CDKN2A(2), CHEK1(1), CHEK2(3), DDB2(1), FAS(2), GTSE1(3), IGFBP3(2), MDM4(1), PTEN(47), RFWD2(1), SERPINB5(4), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53I3(2), TSC2(2), ZMAT3(3)	10269189	152	60	144	55	22	48	2	62	16	2	0.945	1.000	1.000
440	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(9), CD22(2), CD72(1), CD79B(1), CHUK(4), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), LILRB3(2), MALT1(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), NFKB2(2), NFKBIE(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), RASGRP3(1), SYK(3), VAV1(2), VAV2(2), VAV3(3)	11683570	134	60	128	46	33	39	1	53	8	0	0.731	1.000	1.000
441	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(2), DOCK1(2), FOS(1), GRB2(2), HGF(4), ITGB1(1), MAP2K1(2), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(6), MET(7), PAK1(1), PIK3CA(56), PTEN(47), PTPN11(10), RAF1(3), RAP1A(1), RASA1(4), SOS1(5)	7204133	157	60	149	55	14	46	3	85	9	0	0.919	1.000	1.000
442	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), AKT3(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), ITPR1(2), ITPR2(8), ITPR3(5), PDK1(2), PIK3CA(56), PLCG2(5), PPP1R13B(1), PREX1(5), PTEN(47), PTPRC(9), RPS6KA2(3), RPS6KA3(3), SYK(3), TEC(2), VAV1(2)	8962103	160	60	157	57	22	49	1	74	13	1	0.929	1.000	1.000
443	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA2(1), INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), MINPP1(2), OCRL(5), PI4KA(5), PIK3C3(4), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIP5K1B(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PTEN(47), PTPMT1(2), SYNJ1(4), SYNJ2(1)	11988992	163	59	152	61	17	50	4	81	11	0	0.976	1.000	1.000
444	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	70	ACTN1(4), ACTN2(4), ACTN4(1), ACVR1B(3), ACVR1C(2), BAIAP2(1), CDC42(1), CREBBP(13), CTNNA1(2), CTNNA2(5), CTNNB1(21), EGFR(11), EP300(14), FARP2(1), FER(3), FGFR1(2), FYN(2), IGF1R(5), INSR(1), IQGAP1(7), LMO7(2), MAP3K7(2), MAPK3(1), MET(7), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(2), PTPRF(2), PTPRJ(3), PTPRM(10), PVRL1(2), PVRL2(1), PVRL3(1), PVRL4(1), RHOA(1), SMAD3(5), SNAI1(1), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L1(1), TGFBR1(3), TGFBR2(2), TJP1(4), VCL(1), WASF1(3), WASF3(3), WASL(2), YES1(1)	18642103	180	59	175	52	41	56	2	59	21	1	0.357	1.000	1.000
445	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	CPT1B(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(14), MAPK3(1), ME1(3), NCOA1(2), NCOR1(5), NCOR2(6), NR2F1(1), NRIP1(1), PIK3CA(56), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PTGS2(1), RB1(16), RELA(1), SP1(1), SRA1(1), STAT5A(2), STAT5B(1), TNF(1)	10126479	143	59	128	44	31	26	3	65	18	0	0.597	1.000	1.000
446	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT2(1), AKT3(1), BRD4(1), CAP1(1), CBL(7), CDC42(1), CDKN2A(2), F2RL2(2), FLOT1(1), GRB2(2), GSK3B(1), INPPL1(2), IRS1(4), IRS4(6), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(56), PIK3CD(1), PPYR1(3), PTEN(47), PTPN1(1), RAF1(3), RPS6KA2(3), RPS6KA3(3), SERPINB6(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(2), YWHAH(2)	9317817	174	59	164	61	28	47	1	85	13	0	0.878	1.000	1.000
447	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(2), AGT(2), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(3), CREBBP(13), F2(1), FKBP1A(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(2), MAPK14(1), MAPK3(1), MAPK8(6), MYH2(5), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PIK3CA(56), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RAF1(3)	7900776	126	58	115	36	24	31	4	57	10	0	0.418	1.000	1.000
448	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AR(6), BRAF(14), DAG1(2), EGFR(11), GNA15(1), GNAI1(2), GNAQ(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), MAPK10(4), MAPK14(1), PHKA2(4), PIK3CA(56), PIK3CD(1), RAF1(3)	7327289	124	57	119	39	20	26	2	66	9	1	0.709	1.000	1.000
449	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(1), AKT3(1), BTK(1), CDKN2A(2), GRB2(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PIK3CA(56), PPP1R13B(1), PTEN(47), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(5), SOS2(2), TEC(2), YWHAH(2)	5980212	135	57	125	52	12	40	1	75	7	0	0.971	1.000	1.000
450	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), OCRL(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3CA(56), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG1(2), PLCG2(5)	7276040	105	56	96	30	14	28	1	54	8	0	0.659	1.000	1.000
451	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(37), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CDKN2A(2), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F3(1), E2F6(3), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), MNAT1(1), MYT1(5), NACA(5), PCNA(3), POLA2(1), POLE(4), POLE2(1), RB1(16), RBL1(3), TFDP2(1)	11449059	105	55	98	35	18	26	3	42	14	2	0.754	1.000	1.000
452	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A2(2), EIF4G1(2), EIF4G3(3), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PDK2(1), PIK3CA(56), PRKCA(3), PTEN(47)	4467329	122	54	112	47	11	34	2	68	7	0	0.967	1.000	1.000
453	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(1), FCER1A(1), FOS(1), GRB2(2), MAP2K1(2), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PAK2(1), PIK3CA(56), PLA2G4A(3), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(1), SOS1(5), SYK(3), VAV1(2)	6877357	111	54	102	32	21	29	2	50	9	0	0.458	1.000	1.000
454	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	EIF2B5(1), EIF2S3(1), GSK3B(1), IGF1R(5), INPPL1(2), PDK2(1), PIK3CA(56), PTEN(47), RPS6(1)	3068942	115	54	105	43	5	35	1	68	6	0	0.969	1.000	1.000
455	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	BCAR1(1), CDKN1B(2), GRB2(2), ITGB1(1), MAPK3(1), PDK2(1), PIK3CA(56), PTEN(47), SHC1(1), SOS1(5)	2903909	117	54	107	42	5	35	1	68	8	0	0.948	1.000	1.000
456	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), AKT3(1), GRB2(2), MAPK3(1), PDK1(2), PIK3CA(56), PIK3CD(1), PTEN(47), RBL2(2), SHC1(1), SOS1(5)	3391843	119	54	109	44	7	35	1	70	6	0	0.963	1.000	1.000
457	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT2(1), AKT3(1), BRAF(14), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R3(4), PRKAA1(1), PRKAA2(5), RHEB(1), RICTOR(3), RPS6(1), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB2(2), TSC1(1), TSC2(2), ULK1(2), VEGFC(4)	8124955	121	53	109	38	20	30	2	59	10	0	0.684	1.000	1.000
458	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	EIF4A2(2), EIF4B(1), EIF4G1(2), EIF4G3(3), FKBP1A(1), MKNK1(2), PDK2(1), PIK3CA(56), PTEN(47), RPS6(1), TSC1(1), TSC2(2)	4277847	119	53	109	45	10	35	2	66	6	0	0.953	1.000	1.000
459	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT3(1), BCAR1(1), CAPN2(2), CAPN3(1), CAPN5(3), CAPN6(2), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(2), GIT2(1), GRB2(2), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(2), ITGB1(1), ITGB2(2), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), RHO(1), ROCK1(8), ROCK2(5), SDCCAG8(2), SEPP1(1), SHC1(1), SORBS1(4), SOS1(5), TLN1(2), TNS1(5), VAV2(2), VAV3(3), VCL(1), ZYX(3)	21777796	142	52	146	52	36	49	7	27	23	0	0.755	1.000	1.000
460	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(1), BRAF(14), CHUK(4), DAXX(4), FOS(1), GRB2(2), IKBKB(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K5(2), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(3), MAP4K4(1), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK6(1), MAPK8(6), MAPK9(3), MAPKAPK2(1), MAPKAPK5(1), MEF2A(2), MKNK1(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(3), RELA(1), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), RPS6KA5(3), RPS6KB2(2), SHC1(1), SP1(1), STAT1(2), TGFB2(4), TGFBR1(3)	15253500	130	52	130	38	23	36	4	49	18	0	0.416	1.000	1.000
461	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(13), ASH2L(1), CTCFL(1), DOT1L(1), EHMT1(2), EHMT2(3), EZH1(1), EZH2(2), FBXO11(1), HCFC1(2), HSF4(1), JMJD4(1), JMJD6(1), KDM6A(1), MEN1(6), MLL(8), MLL2(8), MLL3(13), MLL4(5), MLL5(6), NSD1(4), OGT(2), PAXIP1(5), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(10), PRMT7(1), PRMT8(3), SATB1(1), SETD1A(1), SETD2(8), SETD7(2), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(4), SUV39H2(1), SUV420H1(4), SUZ12(1), WHSC1(3)	19090018	138	51	136	34	37	38	1	37	24	1	0.254	1.000	1.000
462	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(5), BAX(2), IGF1R(5), KIT(22), PIK3CA(56), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), YWHAH(2)	3262454	102	51	92	35	14	23	1	58	6	0	0.856	1.000	1.000
463	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(2), ALG1(1), ALG10B(4), ALG11(1), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B4GALT1(1), B4GALT3(2), B4GALT5(1), CHST1(1), CHST11(2), CHST12(2), CHST2(2), CHST3(1), CHST4(2), DPAGT1(2), EXT1(2), EXT2(2), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT13(1), GALNT14(1), GALNT2(5), GALNT5(7), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GANAB(1), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), MAN1A1(2), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT4A(1), MGAT4B(1), MGAT5B(1), NDST1(1), NDST2(1), NDST3(4), OGT(2), RPN2(1), ST3GAL1(1), ST6GALNAC1(1), STT3B(2), UST(2), WBSCR17(5), XYLT1(2)	17682677	118	51	117	47	38	34	2	35	9	0	0.869	1.000	1.000
464	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(7), CD28(1), CD3D(1), CSK(2), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(1), FBXW7(37), GRAP2(4), GRB2(2), ITK(5), ITPKB(1), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), NFKBIE(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PLCG1(2), PTPRC(9), RAF1(3), RASGRP1(1), RASGRP2(2), RASGRP3(1), SOS1(5), SOS2(2), VAV1(2)	8931815	114	51	115	32	34	32	1	32	14	1	0.360	1.000	1.000
465	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	CABIN1(2), CAMK4(3), CD3G(1), CD69(2), CNR1(3), CREBBP(13), CTLA4(1), EGR2(2), EP300(14), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(1), GSK3B(1), IFNA1(1), IL10(1), IL1B(1), IL2(1), IL2RA(3), IL6(2), IL8(1), ITK(5), MAP2K7(2), MAPK14(1), MAPK8(6), MAPK9(3), MEF2A(2), MYF5(2), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB2(2), NFKBIE(1), NPPB(1), NUP214(4), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPRC(9), RELA(1), SP1(1), SP3(3), TNF(1), TRPV6(6), VAV1(2), VAV2(2), VAV3(3)	14442763	127	50	130	39	42	34	3	30	18	0	0.313	1.000	1.000
466	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(56), RB1(16), RELA(1), SP1(1)	3102170	89	50	79	32	11	19	2	51	6	0	0.869	1.000	1.000
467	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(3), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD22(2), CD33(1), CD38(1), CD3D(1), CD3G(1), CD44(1), CD5(2), CD55(1), CD7(2), CD8A(1), CR1(1), CR2(2), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), DNTT(2), FLT3(9), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(3), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGAM(1), ITGB3(4), KIT(22), MME(4), TFRC(2), THPO(1), TNF(1), TPO(7)	13368362	120	50	124	35	33	38	3	34	12	0	0.287	1.000	1.000
468	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM17(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(4), CSK(2), EGFR(11), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(4), MAPK10(4), MAPK13(2), MAPK14(1), MAPK8(6), MAPK9(3), MET(7), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG1(2), PLCG2(5), PTPN11(10), PTPRZ1(6), RELA(1), TCIRG1(1), TJP1(4)	11942493	111	50	111	33	25	33	2	41	9	1	0.441	1.000	1.000
469	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADA(1), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADSS(3), AK1(1), AK5(3), ALLC(2), AMPD1(3), AMPD2(1), AMPD3(1), ATIC(1), ATP5A1(3), ATP5C1(3), CANT1(1), DCK(1), ENPP3(2), ENTPD1(1), GDA(1), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(4), NPR1(2), NPR2(2), NT5E(1), PAPSS1(1), PAPSS2(2), PDE1A(2), PDE4B(4), PDE4D(2), PDE5A(4), PDE6C(2), PDE7B(2), PDE9A(1), PFAS(1), PKLR(1), POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1), PPAT(3), PRPS1(1), PRPS1L1(1), PRUNE(1), RRM1(1)	21182558	138	50	139	42	45	45	2	27	19	0	0.338	1.000	1.000
470	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(56), RAF1(3), RB1(16), RELA(1)	3141797	84	50	74	31	13	15	1	48	7	0	0.896	1.000	1.000
471	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	29	DUSP1(1), GORASP1(2), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MAPKAPK5(1), NFKB1(3), NFKB2(2), NFKBIE(1), PIK3CA(56), PIK3CD(1), TRAF3(2), TRAF5(2)	4557967	96	50	87	30	16	24	2	45	9	0	0.649	1.000	1.000
472	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	27	CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(5), INSR(1), MAP2K6(1), MAPK14(1), MEF2A(2), NFATC1(2), NFATC2(2), PIK3CA(56), PPP3CA(2), PPP3CB(1), PPP3CC(2), YWHAH(2)	5096893	84	49	76	30	11	23	1	43	6	0	0.850	1.000	1.000
473	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(2), PIK3CA(56), POLR1A(3), POLR1B(3), RB1(16)	2896692	84	48	74	31	11	19	1	49	4	0	0.906	1.000	1.000
474	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	54	AXIN1(2), CTNNB1(21), DVL2(1), DVL3(2), FBXW2(1), FZD1(2), FZD10(2), FZD3(3), FZD6(5), FZD7(1), FZD9(1), GSK3B(1), LDLR(2), MAPK10(4), MAPK9(3), PLAU(1), PPP2R5C(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RHOA(1), SFRP4(4), TCF7(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1)	8018241	90	46	87	30	21	32	1	25	11	0	0.539	1.000	1.000
475	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ANXA1(1), GNAS(4), GNGT1(1), NFKB1(3), NOS3(2), NR3C1(3), PIK3CA(56), RELA(1)	2544101	71	44	61	24	10	16	3	40	2	0	0.799	1.000	1.000
476	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(5), ABCA12(16), ABCA13(2), ABCA2(1), ABCA3(2), ABCA4(4), ABCA5(3), ABCA6(7), ABCA7(1), ABCA8(9), ABCA9(7), ABCB1(6), ABCB10(1), ABCB4(5), ABCB5(5), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(2), ABCC1(5), ABCC10(2), ABCC11(3), ABCC12(5), ABCC2(5), ABCC3(1), ABCC5(2), ABCC6(4), ABCC8(4), ABCC9(4), ABCD2(3), ABCG1(1), ABCG2(5), CFTR(5), TAP1(2), TAP2(1)	18979757	137	44	154	45	34	51	3	29	19	1	0.376	1.000	1.000
477	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3D(1), CD3G(1), CD80(2), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(5), LCK(1), PIK3CA(56), PTPN11(10)	1885516	83	43	75	26	10	23	1	45	4	0	0.784	1.000	1.000
478	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(4), AMY1B(1), AMY2A(2), AMY2B(3), ASCC3(5), DDX18(1), DDX19A(1), DDX23(4), DDX4(3), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(2), ENPP3(2), EP400(4), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GCK(3), GPI(1), GYS1(1), GYS2(4), HK2(1), HK3(5), IFIH1(2), MOV10L1(7), PGM1(2), PGM3(2), PYGL(2), PYGM(2), RAD54B(2), RUVBL2(2), SETX(10), SI(4), SKIV2L2(2), SMARCA2(3), SMARCA5(5), UGDH(1), UGP2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2), UXS1(1)	20952945	125	43	124	35	31	38	1	31	24	0	0.327	1.000	1.000
479	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	53	BMP2(1), BMP4(1), BMP5(1), BMP6(2), BMP7(1), BTRC(4), CSNK1A1L(1), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(7), GSK3B(1), HHIP(1), LRP2(16), PRKACA(1), PRKACB(1), PRKACG(1), PTCH1(13), PTCH2(2), RAB23(1), SMO(2), STK36(4), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1)	9338760	84	43	84	34	23	29	0	20	12	0	0.835	1.000	1.000
480	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(4), ATM(37), ATR(10), CCNA1(2), CDK4(1), CDKN1B(2), CDKN2A(2), GSK3B(1), RB1(16), TGFB2(4)	5029603	79	42	75	32	11	19	2	32	13	2	0.949	1.000	1.000
481	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	CAT(1), GH1(1), IGF1R(5), PIK3CA(56), SHC1(1)	1925802	64	42	55	24	4	16	1	42	1	0	0.919	1.000	1.000
482	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	PIK3CA(56), PLCB1(1), PLCG1(2), PRKCA(3), VAV1(2)	1975911	64	42	55	21	6	18	1	38	1	0	0.852	1.000	1.000
483	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	CASP9(1), CHUK(4), GH1(1), NFKB1(3), PIK3CA(56), RELA(1), YWHAH(2)	2162415	68	41	59	22	8	17	1	40	2	0	0.734	1.000	1.000
484	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	GRB2(2), MAPK3(1), MEF2A(2), NTRK1(1), PIK3CA(56), PLCG1(2), SHC1(1)	2826733	65	41	57	21	4	15	1	43	2	0	0.814	1.000	1.000
485	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(1), CCKBR(4), CCR3(2), CELSR1(1), CELSR2(2), CELSR3(1), CHRM2(4), CHRM3(2), CXCR3(1), EDNRA(1), EMR2(4), EMR3(1), FSHR(3), GPR116(5), GPR133(1), GPR17(1), GPR18(2), GPR56(1), GPR61(3), GPR77(1), GPR84(3), GRM1(5), LGR6(1), LPHN2(4), LPHN3(4), OR2M4(2), PTGFR(1), SMO(2), SSTR2(2), TAAR5(2), TSHR(4)	9904822	71	41	75	34	23	19	3	21	5	0	0.945	1.000	1.000
486	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), CRADD(1), DAXX(4), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK8(6), NFKB1(3), NUMA1(5), PAK2(1), PRKDC(5), PSEN1(1), RASA1(4), RB1(16), RELA(1), SPTAN1(5), TNF(1), TRAF1(2)	11009050	90	41	91	28	28	21	1	28	12	0	0.625	1.000	1.000
487	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(1), ANAPC4(4), ANAPC5(1), BTRC(4), CDC16(1), CDC27(5), CUL1(1), CUL2(1), FBXW11(1), FBXW7(37), FZR1(1), RBX1(1), SMURF1(2), SMURF2(1), TCEB1(1), UBA1(2), UBE2C(1), UBE2D3(1), UBE2E2(1), WWP1(3), WWP2(1)	6969384	71	40	66	30	18	18	1	19	14	1	0.959	1.000	1.000
488	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), BDKRB2(2), C1S(3), C2(4), C3(2), C3AR1(2), C4B(2), C5(5), C5AR1(1), C6(3), C7(1), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(7), CPB2(1), CR1(1), CR2(2), F13A1(3), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(7), F9(1), FGA(4), FGB(2), KLKB1(3), KNG1(1), MASP1(4), PLAT(1), PLAU(1), PLAUR(2), PLG(4), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(6)	15368900	115	40	122	31	30	43	2	30	10	0	0.174	1.000	1.000
489	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(3), ACSL3(1), ACSL5(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CAMKK2(1), CHUK(4), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(4), IRS4(6), JAK1(2), JAK2(7), JAK3(4), LEPR(6), MAPK10(4), MAPK8(6), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIE(1), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(10), RELA(1), RXRB(1), RXRG(1), SLC2A1(2), SLC2A4(1), TNF(1)	13465728	107	40	107	37	26	35	2	31	11	2	0.684	1.000	1.000
490	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(4), DAXX(4), EGF(1), EGFR(11), ETS1(4), ETS2(1), FOS(1), HOXA7(1), IKBKB(2), MAP2K1(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), NFKB1(3), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), RAF1(3), RELA(1), SP1(1), TNF(1)	8145568	77	40	76	28	24	17	2	29	5	0	0.706	1.000	1.000
491	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(2), CREBBP(13), CTBP2(1), DLL1(4), DLL3(1), DLL4(2), DTX2(2), DTX3(1), DTX3L(1), DVL2(1), DVL3(2), EP300(14), JAG1(1), LFNG(1), MAML1(2), MAML2(1), NCOR2(6), NOTCH1(1), NOTCH2(6), NOTCH3(4), NOTCH4(5), PSEN1(1), PTCRA(1), RBPJ(5), SNW1(1)	9674111	79	39	75	30	21	20	3	17	18	0	0.818	1.000	1.000
492	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(4), ATM(37), BAX(2), CDK4(1), PCNA(3), RB1(16), TIMP3(1)	3023241	64	39	59	22	6	16	2	29	9	2	0.868	1.000	1.000
493	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(37), CDC25C(1), CDK4(1), CHEK1(1), MYT1(5), RB1(16), YWHAH(2)	2975616	63	39	60	21	9	17	2	26	7	2	0.798	1.000	1.000
494	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	55	BAX(2), BFAR(1), BTK(1), CAD(3), CASP3(1), CASP8(1), CASP8AP2(3), CD7(2), DAXX(4), DEDD(1), DFFA(2), EGFR(11), EPHB2(1), IL8(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MET(7), NFKB1(3), NFKB2(2), NFKBIE(1), PTPN13(3), RALBP1(2), ROCK1(8), SMPD1(1), TPX2(1)	11152155	88	39	101	29	19	27	2	29	11	0	0.698	1.000	1.000
495	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), AKT3(1), BRAF(14), DAG1(2), DRD2(2), EGFR(11), EPHB2(1), GRB2(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), PI3(1), PIK3CB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), RAF1(3), RGS20(1), SHC1(1), SOS1(5), SOS2(2), TERF2IP(1)	9550400	73	38	77	24	20	15	1	31	5	1	0.640	1.000	1.000
496	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(1), FBXW7(37), RB1(16)	1497171	54	37	48	23	13	7	1	20	12	1	0.938	1.000	1.000
497	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	62	ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKA(2), CHPT1(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), ESCO1(6), ESCO2(5), ETNK2(1), GNPAT(2), GPAM(1), GPD1L(1), GPD2(1), MYST3(6), MYST4(8), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(3), PTDSS1(3), SH3GLB1(1)	10799817	84	37	85	29	30	25	1	20	8	0	0.605	1.000	1.000
498	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(37), BRCA1(3), CHEK1(1), CHEK2(3), MAPK8(6), MRE11A(5), NFKB1(3), RAD50(7), RBBP8(1), RELA(1)	4934053	71	35	67	20	11	24	4	26	4	2	0.590	1.000	1.000
499	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(1), ADCY8(4), CACNA1A(1), CACNA1B(4), GNAS(4), GNG3(1), ITPR3(5), KCNB1(3), PDE1A(2), PLCB2(1), PRKACA(1), PRKACB(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(4), TAS2R14(1), TAS2R16(2), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R5(2), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2)	8584233	55	34	66	30	20	10	2	15	8	0	0.989	1.000	1.000
500	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ACAT2(1), ACMSD(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), AOC3(1), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2D6(1), CYP2E1(2), CYP2F1(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), KMO(3), KYNU(1), MAOA(2), MAOB(3), TDO2(3), TPH1(2), WARS(1), WARS2(1)	9329079	67	34	66	28	16	24	1	17	9	0	0.919	1.000	1.000
501	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AOC3(1), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), HSD17B10(1), INMT(1), KMO(3), KYNU(1), LNX1(5), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), NFX1(3), OGDH(1), OGDHL(4), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), TDO2(3), TPH1(2), TPH2(3), WARS(1), WARS2(1)	10203360	72	32	71	27	16	29	1	14	12	0	0.769	1.000	1.000
502	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(37), ATR(10), CDC25C(1), CHEK1(1), CHEK2(3), YWHAH(2)	2725096	54	32	49	18	5	16	2	22	7	2	0.870	1.000	1.000
503	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP3(1), CASP6(1), CASP8(1), CFLAR(1), DAXX(4), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MAP2K4(4), MAP3K1(3), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(1), PRKDC(5), PTPN13(3), RB1(16), SPTAN1(5)	6424618	60	31	72	18	13	14	1	22	10	0	0.648	1.000	1.000
504	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(2), CAMK2D(1), CDK5(1), F2(1), FYN(2), GNAI1(2), GNGT1(1), GRB2(2), JAK2(7), MAP2K1(2), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(6), MAPT(1), MYLK(4), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5), STAT1(2), STAT5A(2)	7164918	55	30	55	22	13	16	1	23	1	1	0.881	1.000	1.000
505	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CEL(1), DAK(1), DGAT2(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(7), LIPC(1), LIPF(2), MGLL(1), PNLIP(4), PNLIPRP2(1)	9610237	64	30	66	28	20	19	2	15	8	0	0.878	1.000	1.000
506	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	FOS(1), GRB2(2), IL6(2), IL6R(1), IL6ST(1), JAK1(2), JAK2(7), JAK3(4), MAP2K1(2), MAPK3(1), PTPN11(10), RAF1(3), SHC1(1), SOS1(5)	4017938	42	30	42	15	7	10	0	20	3	2	0.847	1.000	1.000
507	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	CASP3(1), CASP8(1), CRADD(1), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MADD(4), MAP2K4(4), MAP3K1(3), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(1), PRKDC(5), RB1(16), SPTAN1(5), TNF(1)	6147349	57	30	60	22	16	12	1	19	9	0	0.879	1.000	1.000
508	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CREBBP(13), EP300(14), ERCC3(1), ESR1(1), GRIP1(3), GTF2A1(1), GTF2F1(2), HDAC5(1), HDAC6(2), NCOR2(6), NR0B1(1), NRIP1(1), POLR2A(2), SRA1(1)	7620193	52	29	48	19	11	15	3	14	9	0	0.767	1.000	1.000
509	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKA(2), CLC(1), CPT1B(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), GNPAT(2), GPD2(1), LGALS13(1), PAFAH2(1), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G4A(3), PLA2G6(2), PLCB2(1), PLCG1(2), PLCG2(5)	7982003	51	29	53	29	26	9	0	11	5	0	0.988	1.000	1.000
510	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), BHMT(2), CBS(1), CHDH(3), CHKA(2), CPT1B(1), CTH(1), DAO(4), DLD(1), DMGDH(3), GCAT(1), GLDC(3), MAOA(2), MAOB(3), PISD(3), PLCB2(1), PLCG1(2), PLCG2(5), PSPH(1), SARDH(2), SARS(1), SHMT1(1), TARS(3)	6968155	51	28	51	21	23	13	0	10	5	0	0.793	1.000	1.000
511	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	EGFR(11), IGF1R(5), POLR2A(2), PRKCA(3), RB1(16), TERF1(1), TERT(2), TNKS(1), XRCC5(2)	4641364	43	28	42	23	10	7	0	22	4	0	0.989	1.000	1.000
512	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(11), GNAS(4), GNGT1(1), GRB2(2), IGF1R(5), ITGB1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(1), PDGFRA(8), PTPRR(5), RAF1(3), RPS6KA5(3), SHC1(1), SOS1(5)	5569512	57	27	57	20	10	14	3	26	3	1	0.776	1.000	1.000
513	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B2(1), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PKLR(1)	8134846	56	27	55	22	21	14	1	14	6	0	0.680	1.000	1.000
514	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B2(1), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PKLR(1)	8134846	56	27	55	22	21	14	1	14	6	0	0.680	1.000	1.000
515	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(1), ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B2(1), ALDH7A1(2), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGK2(1), PGM1(2), PGM3(2), PKLR(1)	9567461	64	27	63	23	21	19	1	16	7	0	0.557	1.000	1.000
516	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(3), CSTF3(2), DDIT3(1), DDX1(1), DDX20(1), DHX15(2), DHX16(2), DHX38(2), DHX8(2), DHX9(1), DICER1(2), LSM2(1), METTL3(1), NCBP1(4), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PPM1G(1), PRPF18(1), PRPF4(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(3), RNMT(1), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(1), SRPK2(3), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(2), XRN2(2)	17832165	74	27	75	21	23	25	1	15	10	0	0.582	1.000	1.000
517	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(13), DAXX(4), PAX3(3), PML(1), RARA(1), RB1(16), SIRT1(1), SP100(1), TNF(1)	2936774	41	27	38	16	12	2	2	19	6	0	0.808	1.000	1.000
518	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(2), AGTR2(2), EDNRA(1), EDNRB(6), EGF(1), EGFR(11), FOS(1), NFKB1(3), PLCG1(2), PRKCA(3), RELA(1)	3534464	37	26	36	16	14	9	0	12	2	0	0.855	1.000	1.000
519	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), AGPAT1(1), AGPAT4(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), CEL(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), LCT(7), LIPC(1), LIPF(2), PNLIP(4), PNLIPRP2(1)	7826478	49	26	51	24	15	12	2	13	7	0	0.932	1.000	1.000
520	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), BHMT(2), CBS(1), CHDH(3), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(3), GCAT(1), GLDC(3), MAOA(2), MAOB(3), PIPOX(1), PISD(3), PSAT1(1), PSPH(1), RDH11(1), RDH12(1), SARDH(2), SARS(1), SHMT1(1), TARS(3), TARS2(1)	7207978	47	25	47	19	21	15	0	7	4	0	0.738	1.000	1.000
521	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(6), ACACB(3), ACAT2(1), ACOT12(3), ACSS1(1), ACSS2(1), ACYP1(1), AKR1B1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), DLAT(3), DLD(1), GRHPR(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), ME1(3), ME3(1), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	7956504	57	25	57	20	14	20	2	15	6	0	0.608	1.000	1.000
522	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(4), BAX(2), BCL2A1(3), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), CD40(1), CRADD(1), DAXX(4), DFFA(2), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(3), NTRK1(1), PTPN13(3), TNF(1), TRAF1(2), TRAF3(2)	7052170	43	24	50	17	7	11	0	17	8	0	0.899	1.000	1.000
523	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(6), ACAT2(1), ACYP1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), DLAT(3), DLD(1), GRHPR(1), LDHA(4), LDHB(3), ME1(3), ME3(1), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	6186345	47	24	47	21	14	14	2	12	5	0	0.881	1.000	1.000
524	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(1), IFNGR1(2), IFNGR2(1), IKBKB(2), JAK2(7), NFKB1(3), RB1(16), RELA(1), TNF(1), USH1C(4), WT1(4)	2928928	42	24	41	20	10	9	0	17	5	1	0.971	1.000	1.000
525	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(2), FPR1(3), GNA15(1), GNGT1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK14(1), MAPK3(1), NCF2(2), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(3), RELA(1)	6240943	46	23	47	16	17	13	1	9	6	0	0.595	1.000	1.000
526	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GANAB(1), GCK(3), HK2(1), HK3(5), LALBA(1), LCT(7), PFKM(3), PFKP(1), PGM1(2), PGM3(2)	5168450	33	23	33	13	16	9	0	7	1	0	0.632	1.000	1.000
527	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(2), ACADM(3), ACADS(1), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), IVD(1), MCCC1(2), MCEE(2), MUT(1), PCCA(6), PCCB(1)	7509822	43	23	42	15	12	14	1	7	9	0	0.716	1.000	1.000
528	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	ATF1(1), CDC42(1), CREB3(1), CREB5(3), DUSP1(1), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K10(1), MAP3K4(4), MAP3K5(2), MAP3K7(2), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), NFKB1(3)	5509015	38	23	38	15	10	14	2	8	4	0	0.779	1.000	1.000
529	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	30	ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3B2(1), AOC3(1), AOX1(3), DBH(1), DCT(5), FAH(1), GOT1(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(3), TAT(2), TPO(7), TYR(3)	5123388	42	23	41	18	6	16	2	9	9	0	0.871	1.000	1.000
530	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), AOC3(1), DPYD(10), DPYS(2), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), UPB1(2)	4986301	34	22	33	18	7	9	2	9	7	0	0.961	1.000	1.000
531	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GOT1(1), GPI(1), HK2(1), HK3(5), LDHA(4), LDHAL6B(1), LDHB(3), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGK2(1), PKLR(1)	6980960	46	22	46	22	20	14	0	8	4	0	0.837	1.000	1.000
532	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(4), GPRC5B(1), GPRC5C(1), GRM1(5), GRM2(3), GRM3(4), GRM5(5), GRM7(6), GRM8(2)	3319060	33	22	33	15	12	11	1	6	3	0	0.715	1.000	1.000
533	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(3), HK2(1), HK3(5), LALBA(1), LCT(7), PFKM(3), PFKP(1), PGM1(2), PGM3(2), RDH11(1), RDH12(1), UGP2(2)	6091803	37	22	37	13	16	12	0	8	1	0	0.492	1.000	1.000
534	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(2), ACADM(3), ACADS(1), ACAT2(1), ACOX3(2), ACSL3(1), ACSL5(1), ACSL6(1), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), CYP4A11(1), DCI(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), HADHB(1), HSD17B10(1)	8270032	48	22	46	21	10	16	2	11	9	0	0.891	1.000	1.000
535	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B2(1), ALDH7A1(2), AOC3(1), ASPA(2), HAL(1), HARS2(2), HDC(6), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), PRPS1(1), UROC1(3)	6442546	40	22	40	18	13	14	1	6	6	0	0.819	1.000	1.000
536	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX15(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP4A11(1), CYP4F3(1), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GPX6(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2)	6555387	37	22	37	13	16	5	2	6	7	1	0.691	1.000	1.000
537	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADL(2), ACADM(3), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), AOX1(3), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1), HMGCL(1), IVD(1), MCCC1(2), MCEE(2), MUT(1), PCCA(6), PCCB(1)	6229713	40	22	39	15	11	13	1	7	8	0	0.787	1.000	1.000
538	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(2), F2(1), F5(7), F7(1), F8(7), F9(1), FGA(4), FGB(2), LPA(2), PLAT(1), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(2), VWF(6)	6046167	42	21	42	20	13	15	1	9	4	0	0.927	1.000	1.000
539	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AOC3(1), DPYD(10), DPYS(2), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HIBCH(1), UPB1(2)	4594991	34	21	33	17	6	10	2	9	7	0	0.943	1.000	1.000
540	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), CHRM2(4), CHRM3(2), CHRM5(1), DRD2(2), DRD3(1), DRD5(4), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1)	4011219	43	21	43	17	16	16	1	6	4	0	0.433	1.000	1.000
541	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(7), EGF(1), EGFR(11), GRB2(2), MAP2K1(2), MAPK3(1), PTPRB(2), RAF1(3), RASA1(4), SHC1(1), SOS1(5), SPRY1(1)	3933965	40	21	40	14	9	8	0	21	2	0	0.735	1.000	1.000
542	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	ABO(2), B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(1), B4GALT3(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), PIGG(3), PIGK(2), PIGM(2), PIGN(1), PIGO(2), PIGP(1), PIGS(2), PIGT(2), PIGU(1), PIGV(2), PIGX(2), ST3GAL1(1), ST3GAL6(4), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(3)	7658470	54	20	55	22	16	19	1	10	8	0	0.855	1.000	1.000
543	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), F2(1), F5(7), F8(7), F9(1), FGA(4), FGB(2), KLKB1(3), PROS1(3), SERPING1(2)	7822247	44	20	44	17	11	17	1	10	5	0	0.775	1.000	1.000
544	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN2(2), CXCR3(1), EGF(1), EGFR(11), ITGB1(1), MAPK3(1), MYLK(4), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), TLN1(2)	5566718	35	20	35	17	9	9	0	13	4	0	0.949	1.000	1.000
545	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP4K2(1), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TANK(3), TNF(1)	3935858	35	19	35	12	10	12	2	10	1	0	0.620	1.000	1.000
546	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CDK4(1), CDKN1B(2), CDKN2A(2), RB1(16), RBL1(3)	2691378	26	18	25	14	6	2	0	12	6	0	0.961	1.000	1.000
547	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(11), ERBB3(4), NRG1(7)	1818440	23	18	23	10	5	4	0	12	2	0	0.919	1.000	1.000
548	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2D6(1), CYP2E1(2), CYP2F1(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), PON1(1)	4786977	33	18	33	11	13	6	0	10	3	1	0.580	1.000	1.000
549	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), CLYBL(1), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(1), IDH3A(3), OGDH(1), OGDHL(4), PC(4), PCK1(3), SDHA(2), SUCLA2(3), SUCLG1(1)	5075671	30	18	30	14	7	10	0	10	3	0	0.913	1.000	1.000
550	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CEL(1), CYP7A1(1), HADHB(1), RDH11(1), RDH12(1), SLC27A5(2)	5301152	31	18	30	13	6	10	1	8	6	0	0.829	1.000	1.000
551	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AACS(2), AADAC(2), ACADS(1), ACAT2(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), BDH1(1), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HMGCL(1), HMGCS2(1), HSD17B10(1), ILVBL(1), PDHA1(1), PDHA2(3), PLA1A(2), PRDX6(1), RDH11(1), RDH12(1)	6705489	37	18	36	21	13	12	2	5	5	0	0.970	1.000	1.000
552	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(2), CUL1(1), NEDD8(1), RB1(16), RBX1(1)	1501449	21	18	20	13	5	1	0	9	6	0	0.983	1.000	1.000
553	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(1), JAK1(2), JAK2(7), JAK3(4), PTPRU(6), REG1A(2)	2571607	24	18	24	10	11	3	0	6	2	2	0.865	1.000	1.000
554	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(7), CASP3(1), CASP8(1), CFLAR(1), MAP2K4(4), MAP3K3(2), MAP3K7(2), NFKB1(3), NFKB2(2), NFKBIE(1), RALBP1(2), TNF(1), TNFAIP3(3)	4296206	32	18	30	12	10	10	1	7	4	0	0.721	1.000	1.000
555	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(4), EGR2(2), GNAQ(1), MAP3K1(3), NFATC1(2), NFATC2(2), NFKB1(3), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RELA(1)	4523469	35	18	35	13	16	9	0	6	4	0	0.657	1.000	1.000
556	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(1), IDH3A(3), PC(4), PCK1(3), SDHA(2), SUCLA2(3), SUCLG1(1)	3477598	24	17	24	12	5	9	0	7	3	0	0.935	1.000	1.000
557	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(1), DDX20(1), ETS1(4), ETS2(1), ETV3(1), FOS(1), HDAC5(1), NCOR2(6), RBL1(3), RBL2(2), SIN3A(8), SIN3B(1)	4222434	31	17	29	11	9	9	0	9	4	0	0.719	1.000	1.000
558	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), CAD(3), CPS1(8), EPRS(4), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), GPT(1), GSS(1), PPAT(3), QARS(1)	6723086	30	17	30	14	7	10	2	6	5	0	0.915	1.000	1.000
559	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(4), ALG11(1), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(2), DHDDS(2), DPAGT1(2), FUT8(1), GANAB(1), MAN1A1(2), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT4A(1), MGAT4B(1), MGAT5B(1), RPN2(1), STT3B(2)	6822655	36	17	36	17	10	10	1	10	5	0	0.920	1.000	1.000
560	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(2), FUCA1(2), FUCA2(1), GNS(3), HEXA(1), HEXB(2), HPSE(2), HPSE2(4), HYAL2(1), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(1), MANBA(1), NAGLU(1), SPAM1(4)	5375280	35	17	34	15	13	9	0	8	5	0	0.819	1.000	1.000
561	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(3), DLD(1), DLST(1), FH(1), IDH2(1), IDH3A(3), OGDH(1), PC(4), PDHA1(1), PDHA2(3), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(2), SUCLA2(3), SUCLG1(1)	4826227	32	17	32	16	9	11	0	9	3	0	0.944	1.000	1.000
562	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(2), ALDH3B2(1), AOC3(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(2), MAOB(3), MPO(4), PRDX1(1), PRDX6(1), TAT(2), TPO(7)	3582040	28	17	28	13	8	11	1	2	6	0	0.831	1.000	1.000
563	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), EGFR(11), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(6), RARA(1)	2773802	25	16	23	12	5	6	0	11	3	0	0.970	1.000	1.000
564	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(10), DPYS(2), ENPP3(2), ILVBL(1), PANK3(1), PPCS(2), UPB1(2), VNN1(2)	2819921	23	16	23	12	4	10	1	4	4	0	0.951	1.000	1.000
565	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(4), FARS2(2), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(3), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1)	9102115	39	16	39	15	8	16	1	9	5	0	0.864	1.000	1.000
566	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	35	ANKHD1(3), EEF1B2(2), EEF1D(3), EEF2K(1), EIF2AK2(2), EIF2AK3(1), EIF2B2(1), EIF2B5(1), EIF2S3(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(2), EIF4G3(3), EIF5A(1), ETF1(3), PAIP1(3)	6953711	30	16	29	11	7	9	1	9	4	0	0.804	1.000	1.000
567	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), CEL(1), CYP7A1(1), HADHB(1)	3931589	22	15	21	12	3	6	1	7	5	0	0.957	1.000	1.000
568	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAX(2), CASP8(1), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), NFKB1(3), NSMAF(3), RAF1(3), RELA(1), SMPD1(1)	3442960	30	15	30	11	8	11	1	6	4	0	0.736	1.000	1.000
569	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B2(1), AOC3(1), ASPA(2), HAL(1), HDC(6), MAOA(2), MAOB(3), PRPS1(1)	4103742	24	15	24	15	6	9	1	4	4	0	0.974	1.000	1.000
570	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ADSS(3), AGXT2(1), ASL(2), ASPA(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DARS2(1), DLAT(3), DLD(1), GAD1(2), GOT1(1), GPT(1), NARS(1), NARS2(3), PC(4), PDHA1(1), PDHA2(3)	6299155	36	15	36	22	15	11	1	6	3	0	0.988	1.000	1.000
571	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(3), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(3), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKG1(6), PRKG2(2)	5325391	32	15	32	16	8	14	0	7	3	0	0.908	1.000	1.000
572	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CUL1(1), RB1(16)	1535334	19	15	18	14	3	1	0	10	5	0	0.995	1.000	1.000
573	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HMGCL(1), PDHA1(1), PDHA2(3)	4452904	23	14	22	16	7	6	2	5	3	0	0.990	1.000	1.000
574	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CAD(3), CPS1(8), EPRS(4), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), GPT(1), GSS(1), PPAT(3), QARS(1)	5652219	27	14	27	10	7	8	1	6	5	0	0.766	1.000	1.000
575	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(3)	3994212	27	14	27	11	13	8	1	3	2	0	0.724	1.000	1.000
576	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), SLC23A1(1), SLC23A2(1), SLC2A1(2), SLC2A3(1)	4470623	19	14	19	12	7	7	0	2	3	0	0.956	1.000	1.000
577	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR1(2), AGTR2(2), COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), REN(2)	4548161	25	13	25	13	7	12	0	3	3	0	0.941	1.000	1.000
578	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	GNS(3), HEXA(1), HEXB(2), HPSE(2), HPSE2(4), HYAL2(1), LCT(7), NAGLU(1), SPAM1(4)	3306781	25	13	24	10	9	8	0	6	2	0	0.726	1.000	1.000
579	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(7), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SMPD1(1), SMPD4(1), SPHK1(1), SPTLC1(1), UGT8(2)	5317967	24	13	24	14	10	5	0	6	2	1	0.947	1.000	1.000
580	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), BST1(1), CD38(1), ENPP3(2), NADK(3), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(2), NNT(3), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1)	3774751	23	13	23	10	8	5	0	4	6	0	0.869	1.000	1.000
581	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(10), DPYS(2), ENPP3(2), PANK3(1), PPCS(2), UPB1(2)	2239649	20	13	20	10	4	7	1	4	4	0	0.930	1.000	1.000
582	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(4), DUSP1(1), IKBKB(2), MAP3K1(3), NFKB1(3), RELA(1), TANK(3), TNFAIP3(3), TRAF1(2), TRAF3(2)	3802175	24	13	24	12	8	8	0	7	1	0	0.906	1.000	1.000
583	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSS(3), AGXT2(1), ASL(2), ASPA(2), CAD(3), CRAT(1), DARS(1), GAD1(2), GOT1(1), GPT(1), NARS(1), PC(4)	4326302	23	12	23	15	9	8	1	3	2	0	0.980	1.000	1.000
584	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(4), DUSP1(1), IKBKB(2), MAP3K1(3), NFKB1(3), RELA(1), TNFAIP3(3), TRAF3(2)	3123517	19	12	19	10	4	8	0	6	1	0	0.946	1.000	1.000
585	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(2), FBP2(1), GOT1(1), GPT(1), ME1(3), ME3(1), PGK2(1), PKLR(1), TKT(1), TKTL1(1), TKTL2(3)	3379409	16	12	16	15	9	3	1	2	1	0	0.994	1.000	1.000
586	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXA(1), HEXB(2), LCT(7), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(3)	2799392	20	11	20	11	8	6	0	5	1	0	0.903	1.000	1.000
587	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(1), CHUK(4), IKBKB(2), IL2(1), MAP3K1(3), MAP3K5(2), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF9(1)	3296986	25	10	25	10	5	12	1	7	0	0	0.816	1.000	1.000
588	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), MAP2K1(2), MAPK3(1), NFKB1(3), PLCB1(1), PRKCA(3), RAF1(3), RELA(1), TNF(1)	2578201	19	10	19	10	9	3	0	5	2	0	0.871	1.000	1.000
589	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), IKBKB(2), IL1R1(1), MAP3K1(3), MAP3K7(2), MYD88(1), NFKB1(3), RELA(1), TLR4(3), TNF(1), TNFAIP3(3)	3965191	24	10	24	10	6	8	0	9	1	0	0.831	1.000	1.000
590	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	BTK(1), EEA1(4), GSK3B(1), PFKM(3), PFKP(1), PLCG1(2), PRKCE(2), PRKCZ(1), RAB5A(1), VAV2(2)	4056732	18	10	18	12	5	9	0	3	1	0	0.972	1.000	1.000
591	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(1), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(1)	1117529	11	9	11	7	4	3	0	4	0	0	0.914	1.000	1.000
592	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	GAL3ST1(2), LCT(7), SMPD1(1), SPTLC1(1)	3716848	11	9	11	10	5	2	0	3	1	0	0.989	1.000	1.000
593	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(2), FBP2(1), GOT1(1), GPT(1), ME1(3), ME3(1), PKLR(1), TKT(1)	3007264	11	8	11	12	8	1	0	1	1	0	0.995	1.000	1.000
594	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), IDH2(1), OGDH(1), SDHA(2), SUCLA2(3)	1619800	8	8	8	6	0	5	0	3	0	0	0.979	1.000	1.000
595	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), HIF1A(2), JAK2(7), NFKB1(3), RELA(1)	2135638	14	7	14	10	5	1	0	5	2	1	0.989	1.000	1.000
596	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT3(1), CHST11(2), CHST12(2), CHST3(1), DSE(1), UST(2), XYLT1(2)	2070476	11	7	11	9	6	2	0	3	0	0	0.975	1.000	1.000
597	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	EBP(1), FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	3173163	12	6	13	8	6	5	0	1	0	0	0.938	1.000	1.000
598	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), ILVBL(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(3)	2843530	8	6	8	7	3	2	0	3	0	0	0.982	1.000	1.000
599	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(3), PC(4), PDHA1(1)	1480805	8	6	8	5	6	2	0	0	0	0	0.861	1.000	1.000
600	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1A(2), PDE1B(1), PLCB1(1), PLCB2(1), PRL(1), TRH(1)	1881264	8	6	8	5	1	5	0	2	0	0	0.926	1.000	1.000
601	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2B5(1), EIF2S3(1), GSK3B(1)	1959086	6	5	6	3	0	3	0	3	0	0	0.876	1.000	1.000
602	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), IL8(1), NFKB1(3), RELA(1), TNF(1)	1720608	8	5	8	6	4	1	1	2	0	0	0.953	1.000	1.000
603	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF11A(1)	1830014	14	5	14	8	6	5	1	2	0	0	0.918	1.000	1.000
604	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(3)	1742691	7	5	7	4	3	1	0	3	0	0	0.871	1.000	1.000
605	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), HMGCL(1), HMGCS2(1)	1276821	4	4	4	3	3	1	0	0	0	0	0.899	1.000	1.000
606	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(4), NFKB1(3), RELA(1)	1473166	8	4	8	5	4	1	0	3	0	0	0.931	1.000	1.000
607	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1), CES1(1), ESD(1)	1005707	3	3	3	6	0	2	0	1	0	0	0.998	1.000	1.000
608	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1), TNF(1)	875299	3	3	3	4	2	0	0	1	0	0	0.990	1.000	1.000
609	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	GPI(1), PKLR(1)	1459705	2	2	2	4	1	0	0	1	0	0	0.991	1.000	1.000
610	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(2)	753381	2	2	2	3	0	2	0	0	0	0	0.990	1.000	1.000
611	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(3)	1063548	4	2	4	3	1	1	0	2	0	0	0.951	1.000	1.000
612	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(1)	602223	2	2	2	2	1	1	0	0	0	0	0.943	1.000	1.000
613	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), OAT(1)	889382	2	1	2	2	1	0	0	1	0	0	0.952	1.000	1.000
614	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1), IL2(1)	521899	2	1	2	2	0	2	0	0	0	0	0.969	1.000	1.000
615	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CHEK1(1)	1129050	1	1	1	3	0	0	0	1	0	0	0.997	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		92179	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
