rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(6), ATM(37), BAX(2), CPB2(1), CSNK1D(1), FHL2(1), HIF1A(2), IGFBP3(2), MAPK8(6), TP53(109)	3403276	167	98	127	17	48	36	6	43	32	2	4.37e-06	<1.00e-15	<1.71e-13
2	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(4), BAX(2), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), FAS(2), GZMB(1), MAP2K4(4), MAP3K1(3), MAPK10(4), NFKB1(3), PARP1(1), PRF1(1), RELA(1), TNF(1), TNFSF10(1), TP53(109), TRAF1(2)	6152577	152	95	112	15	50	30	4	31	37	0	3.81e-07	<1.00e-15	<1.71e-13
3	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK4(1), CDKN1B(2), CDKN2A(2), PRB1(2), TP53(109)	1293032	116	94	78	10	41	17	3	25	30	0	3.70e-06	<1.00e-15	<1.71e-13
4	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(153), CASP3(1), CREB3(1), CREB5(3), DAG1(2), EPHB2(1), FOS(1), GNAQ(1), ITPKB(1), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3)	4369054	185	110	152	30	10	18	2	46	70	39	0.00127	1.11e-15	1.71e-13
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	SP1(1), SP3(3), TP53(109), WT1(4)	1194152	117	92	79	7	42	18	3	27	27	0	2.12e-08	2.66e-15	2.85e-13
6	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(2), IFNGR2(1), IKBKB(2), JAK2(7), NFKB1(3), RB1(16), RELA(1), TNF(1), TP53(109), USH1C(4), WT1(4)	3076498	151	95	112	25	49	26	3	41	31	1	0.00228	2.78e-15	2.85e-13
7	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(4), ATM(37), BAX(2), CASP3(1), CASP6(1), CASP9(1), PRKCA(3), STAT1(2), TLN1(2), TP53(109)	4715253	162	97	121	17	43	36	5	43	33	2	7.18e-06	3.77e-15	3.04e-13
8	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(37), BRCA1(3), CHEK1(1), CHEK2(3), MAPK8(6), MRE11A(5), NFKB1(3), RAD50(7), RBBP8(1), RELA(1), TP53(109)	5081623	180	99	138	25	50	41	7	50	30	2	0.000419	4.11e-15	3.04e-13
9	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(4), NFKB1(3), RELA(1), TP53(109)	1620736	117	93	79	10	43	18	3	27	26	0	1.33e-05	4.44e-15	3.04e-13
10	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(13), DAXX(4), PAX3(3), PML(1), RARA(1), RB1(16), SIRT1(1), SP100(1), TNF(1), TP53(109)	3084344	150	96	109	21	51	19	5	43	32	0	9.59e-05	5.11e-15	3.15e-13
11	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(37), CDC25C(1), CDK4(1), CHEK1(1), MYT1(5), RB1(16), TP53(109), YWHAH(2)	3123186	172	98	131	26	48	34	5	50	33	2	0.00189	3.40e-13	1.90e-11
12	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(4), ATM(37), BAX(2), CDK4(1), PCNA(3), RB1(16), TIMP3(1), TP53(109)	3170811	173	99	130	27	45	33	5	53	35	2	0.00232	4.33e-13	2.22e-11
13	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(2), APC(153), AXIN1(2), BTRC(4), CTNNB1(21), DLL1(4), FZD1(2), GSK3B(1), NOTCH1(1), PSEN1(1)	2934386	191	110	156	34	8	20	1	55	68	39	0.00594	7.91e-13	3.75e-11
14	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(37), ATR(10), CDC25C(1), CHEK1(1), CHEK2(3), TP53(109), YWHAH(2)	2872666	163	98	120	23	44	33	5	46	33	2	0.00506	6.33e-11	2.79e-09
15	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(153), AXIN1(2), BTRC(4), CREBBP(13), CSNK1D(1), CTNNB1(21), FZD1(2), GSK3B(1), MAP3K7(2), PPARD(1)	4652324	200	110	163	36	9	21	2	61	68	39	0.00544	1.04e-07	4.28e-06
16	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	ATF2(1), CDC42(1), DLD(1), DUSP10(1), GCK(3), IL1R1(1), MAP2K4(4), MAP2K5(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK8(6), MAPK9(3), NFATC3(2), PAPPA(6), SHC1(1), TP53(109), ZAK(4)	8338755	174	102	135	25	58	35	5	38	38	0	8.50e-05	2.06e-07	7.95e-06
17	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(37), ATR(10), BRCA1(3), CDC25C(1), CHEK1(1), CHEK2(3), EP300(14), MYT1(5), PRKDC(5), TP53(109), YWHAH(2)	6952227	190	98	151	28	52	38	6	55	37	2	0.000388	3.23e-06	0.000117
18	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(11), IGF1R(5), POLR2A(2), PRKCA(3), RB1(16), TERF1(1), TERT(2), TNKS(1), TP53(109), XRCC5(2)	4788934	152	96	113	28	49	24	3	46	30	0	0.00445	3.48e-06	0.000119
19	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(3), APC(153), ATF2(1), AXIN1(2), BMP10(2), BMP2(1), BMP4(1), BMP5(1), BMP7(1), BMPR2(3), CHRD(2), CTNNB1(21), FZD1(2), GSK3B(1), MAP3K7(2), NPPB(1), RFC1(5), TGFB2(4), TGFBR1(3), TGFBR2(2), TGFBR3(3)	5846437	214	111	179	37	16	30	0	61	68	39	0.00273	6.69e-06	0.000217
20	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(4), BAX(2), BCL2L11(1), BIRC2(2), BIRC3(7), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), CHUK(4), DFFA(2), FAS(2), GZMB(1), HELLS(1), IKBKB(2), IRF1(1), IRF3(2), IRF4(2), MAP2K4(4), MAP3K1(3), MAPK10(4), NFKB1(3), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), TNF(1), TNFRSF10B(4), TNFRSF21(1), TNFSF10(1), TP53(109), TRAF1(2), TRAF3(2)	9335075	178	98	138	23	57	40	4	37	40	0	8.25e-06	9.80e-06	0.000302
21	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT2(1), AKT3(1), APC(153), AXIN1(2), AXIN2(3), CER1(2), CTNNB1(21), DACT1(1), DKK1(1), DKK2(3), DKK3(2), DKK4(3), FSTL1(1), GSK3B(1), LRP1(4), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(1), TSHB(1)	6413427	204	111	169	36	11	27	0	60	67	39	0.00584	2.26e-05	0.000661
22	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(153), CDH1(12), CREBBP(13), EP300(14), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(2), TGFB2(4), TGFBR1(3), TGFBR2(2)	4534542	208	109	173	38	11	17	2	63	76	39	0.00717	3.37e-05	0.000943
23	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(153), AXIN1(2), CREBBP(13), CTNNB1(21), EP300(14), FZD1(2), GSK3B(1), LDB1(2), TRRAP(9)	5487282	217	110	179	41	13	24	2	66	73	39	0.00603	0.000633	0.0170
24	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(2), APC(153), CAV3(1), DAG1(2), EPHB2(1), GNAI1(2), GNAQ(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), RHO(1), RYR1(12)	7367767	192	108	166	38	18	21	0	45	68	40	0.00976	0.00352	0.0904
25	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(4), CDKN2A(2), PIK3CA(56), PIK3R1(9), POLR1A(3), POLR1B(3), RB1(16), TP53(109)	3319067	202	101	154	37	52	36	4	76	32	2	0.00392	0.00789	0.194
26	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(37), ATR(10), BRCA1(3), BRCA2(22), CHEK1(1), CHEK2(3), FANCA(3), FANCD2(7), FANCF(1), FANCG(2), HUS1(1), MRE11A(5), RAD17(2), RAD50(7), TP53(109)	7786683	213	99	168	31	49	54	7	63	38	2	0.000625	0.0270	0.639
27	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(9), NRG2(2), NRG3(4), PRKCA(3), PSEN1(1)	1586122	21	16	21	3	6	7	2	3	3	0	0.115	0.0302	0.689
28	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	APC(153), AXIN1(2), CTNNB1(21), FZD1(2), GJA1(4), GNAI1(2), GSK3B(1), LBP(1), MYD88(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RELA(1), TLR4(3)	4812250	259	113	215	54	17	37	1	96	67	41	0.0170	0.0617	1.000
29	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	129236	4	3	4	0	3	1	0	0	0	0	0.274	0.0665	1.000
30	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(2), APAF1(4), CASP3(1), CASP9(1), DAXX(4), FAS(2), HSPB2(1), MAPKAPK2(1), TNF(1)	1838947	17	14	16	1	1	3	0	11	2	0	0.119	0.0668	1.000
31	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(3), HSD3B1(1), HSD3B2(1)	1477777	14	13	13	3	3	5	0	2	4	0	0.453	0.0869	1.000
32	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(2), CYP11B1(4), CYP21A2(3), HSD3B1(1), HSD3B2(1)	1477777	14	13	13	3	3	5	0	2	4	0	0.453	0.0869	1.000
33	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(4), GNGT1(1), PRKACA(1), PRKAR1A(5)	974544	16	14	16	3	5	4	2	3	2	0	0.245	0.0915	1.000
34	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1)	660538	9	7	9	1	5	2	0	0	2	0	0.253	0.102	1.000
35	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), COPS5(1), EP300(14), HIF1A(2), LDHA(4), NOS3(2), VHL(22)	2764303	49	31	49	9	10	11	0	21	7	0	0.111	0.110	1.000
36	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(3)	352237	4	4	4	1	0	3	0	1	0	0	0.665	0.157	1.000
37	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), SNAP25(1), STX1A(1)	555266	5	5	5	1	0	3	0	2	0	0	0.569	0.161	1.000
38	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(4), GNGT1(1), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2508498	30	21	30	6	14	6	2	6	2	0	0.126	0.162	1.000
39	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(2), HLA-DRA(1), HLA-DRB1(1)	435215	5	4	6	2	2	0	0	1	2	0	0.875	0.165	1.000
40	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), GRIA2(6)	560749	7	6	7	2	2	3	0	2	0	0	0.491	0.175	1.000
41	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(1)	395820	3	3	3	1	1	0	0	2	0	0	0.695	0.191	1.000
42	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(4), ARHGAP5(8), CASP3(1), CASP8(1), CASP9(1), GZMB(1), PRF1(1)	2208499	17	14	13	2	0	2	1	9	5	0	0.306	0.193	1.000
43	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(4), GNGT1(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3)	1549522	18	14	18	3	7	4	2	3	2	0	0.161	0.209	1.000
44	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(1)	211832	2	2	2	0	0	0	0	1	1	0	0.788	0.222	1.000
45	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(3), ADORA3(1), LTB4R(1), P2RY1(3), P2RY2(2), P2RY6(1)	865591	15	9	15	2	7	6	0	2	0	0	0.0579	0.223	1.000
46	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2162414	16	13	16	3	8	3	0	2	3	0	0.197	0.263	1.000
47	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GPX1(1), PRKCE(2)	1274748	19	9	20	2	6	8	1	3	1	0	0.0471	0.266	1.000
48	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(1), GAD1(2), HDC(6), TPH1(2)	871833	11	8	11	2	3	6	0	1	1	0	0.286	0.283	1.000
49	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(3), MAP2K1(2), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(3)	1238125	12	8	12	3	6	1	0	4	1	0	0.406	0.289	1.000
50	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(1), CD3G(1), GZMB(1), HLA-A(3), ITGAL(3), ITGB2(2), PRF1(1)	1350876	14	10	14	4	2	2	1	4	4	1	0.549	0.293	1.000
51	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GPHN(2)	2093736	21	11	22	1	7	9	0	4	1	0	0.0165	0.298	1.000
52	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3G(1), CREBBP(13), CSK(2), GNAS(4), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PTPRC(9)	3670052	49	26	48	9	15	11	4	11	8	0	0.0645	0.339	1.000
53	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3G(1), CREBBP(13), CSK(2), GNAS(4), GNGT1(1), HLA-DRA(1), HLA-DRB1(1), LCK(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PTPRC(9)	3670052	49	26	48	9	15	11	4	11	8	0	0.0645	0.339	1.000
54	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(4), BAX(2), BCL2L11(1), CASP8AP2(3), CASP9(1), CES1(1)	1677948	12	13	15	2	1	6	0	2	3	0	0.533	0.357	1.000
55	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), NFS1(1), TPK1(5)	1112829	11	8	11	2	4	5	0	2	0	0	0.408	0.384	1.000
56	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK2(1), HK3(5), IMPA2(1), PGM1(2), PGM3(2), TGDS(1)	1884988	15	13	15	2	10	3	0	1	1	0	0.0784	0.411	1.000
57	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK2(1), HK3(5), PGM1(2), PGM3(2), TGDS(1)	1721912	14	12	14	2	9	3	0	1	1	0	0.109	0.420	1.000
58	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(8), PIK3CA(56), PIK3R1(9), WASL(2)	2348367	80	45	71	20	8	17	2	45	6	2	0.365	0.437	1.000
59	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(1)	522952	3	3	3	1	1	2	0	0	0	0	0.706	0.454	1.000
60	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(13), DFFA(2), GZMA(3), GZMB(1), PRF1(1)	1745786	22	13	20	5	5	4	3	7	3	0	0.301	0.458	1.000
61	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(2), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL5RA(2), IL6(2)	870462	10	6	11	4	5	2	0	1	2	0	0.791	0.464	1.000
62	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), DLL1(4), FURIN(3), NOTCH1(1), PSEN1(1)	1033414	11	8	11	3	5	0	1	1	4	0	0.449	0.466	1.000
63	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2), SHMT1(1)	576879	3	3	3	1	0	1	0	0	2	0	0.909	0.466	1.000
64	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(4), BAX(2), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), DFFA(2)	2329837	21	11	19	1	3	9	0	3	6	0	0.0654	0.483	1.000
65	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(1), HLA-DRB1(1)	334065	3	2	4	0	2	0	0	0	1	0	0.466	0.493	1.000
66	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), GRB2(2), IL2(1), IL2RA(3), IL2RB(1), IL2RG(1), JAK1(2), JAK3(4), LCK(1), MAP2K1(2), MAPK3(1), MAPK8(6), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(3)	3921740	40	21	40	5	8	11	1	12	7	1	0.0452	0.519	1.000
67	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(4), ACTN2(4), BCAR1(1), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), VCL(1)	3009756	40	33	38	9	9	13	0	17	1	0	0.265	0.521	1.000
68	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(3), ITGB1(1), KLRC3(1), KLRC4(1), LAT(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3CA(56), PIK3R1(9), SYK(3), VAV1(2)	3181354	83	48	74	19	7	18	1	47	7	3	0.351	0.527	1.000
69	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(3), DNMT1(8), MTNR1A(1), MTNR1B(4), PTGDR(2), PTGFR(1)	1710085	19	15	19	4	12	4	1	2	0	0	0.118	0.529	1.000
70	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), GNAS(4), PLCE1(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RAP2B(1)	2354815	22	15	22	4	8	6	2	4	2	0	0.146	0.548	1.000
71	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2660046	17	12	17	2	3	7	0	7	0	0	0.130	0.550	1.000
72	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2660046	17	12	17	2	3	7	0	7	0	0	0.130	0.550	1.000
73	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2660046	17	12	17	2	3	7	0	7	0	0	0.130	0.550	1.000
74	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	268868	3	2	3	1	0	2	0	1	0	0	0.844	0.575	1.000
75	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(3)	362688	4	2	4	0	1	1	0	2	0	0	0.382	0.576	1.000
76	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(1), IL12A(1), IL12RB2(5), IL18R1(3), IL2(1), IL2RA(3)	2098879	19	11	20	2	6	6	0	4	3	0	0.0588	0.584	1.000
77	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(1), CTH(1), GOT1(1), LDHA(4), LDHB(3)	1142110	10	6	10	2	2	4	0	3	1	0	0.438	0.584	1.000
78	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(8), ARHGEF1(2), GNA12(1), GNAQ(1), GNGT1(1), MYLK(4), PLCB1(1), PPP1R12B(5), PRKCA(3), ROCK1(8)	3595863	34	21	31	6	8	9	0	10	7	0	0.160	0.585	1.000
79	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), CFTR(5), GNAS(4), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2091976	24	15	24	5	8	7	2	4	3	0	0.183	0.592	1.000
80	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD80(2), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL2(1)	623305	7	3	8	0	2	3	0	1	1	0	0.161	0.597	1.000
81	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(1)	2774784	17	12	17	2	3	7	0	7	0	0	0.129	0.606	1.000
82	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(3), G6PD(2), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GPX6(1), GSS(1), GSTA2(1), GSTA3(1), GSTA5(2), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(3), IDH2(1), TXNDC12(2)	3456004	27	20	27	5	5	9	1	9	3	0	0.214	0.607	1.000
83	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), CD3G(1), IL2(1), IL2RA(3), TGFB2(4), TGFBR1(3), TGFBR2(2), TGFBR3(3), TOB1(2)	1854560	21	10	21	3	4	6	0	7	4	0	0.152	0.612	1.000
84	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(3), F2(1), FGA(4), FGB(2), PLAT(1), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(2)	2387283	20	9	19	0	10	5	0	3	2	0	0.00169	0.620	1.000
85	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(14), ESR1(1), MAPK3(1)	2464988	29	18	27	7	6	5	2	9	7	0	0.354	0.624	1.000
86	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(14), NCOA1(2), NCOA2(2)	2975876	31	19	31	6	10	4	2	9	6	0	0.149	0.630	1.000
87	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(2), RB1(16), SP1(1), SP3(3)	1195984	22	19	21	9	5	3	0	10	4	0	0.823	0.640	1.000
88	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(6), MMP9(5), RECK(2), TIMP1(1), TIMP3(1)	1278668	16	10	16	3	8	3	0	3	2	0	0.169	0.652	1.000
89	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), SH3GLB1(1)	2758978	27	15	26	5	5	10	0	10	2	0	0.239	0.657	1.000
90	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), SDHA(2)	1113200	6	5	6	1	1	1	0	4	0	0	0.476	0.658	1.000
91	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(1), ALOX15(1), DPEP1(1), GGT1(2), PLA2G6(2), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2)	2421565	12	12	12	2	6	1	0	0	5	0	0.389	0.659	1.000
92	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS2(1), PON1(1), PON2(1), PON3(4), RDH11(1), RDH12(1)	1430039	9	8	7	3	3	2	0	3	1	0	0.653	0.661	1.000
93	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD3G(1)	592941	3	3	3	0	1	0	0	1	1	0	0.559	0.665	1.000
94	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(1), FYN(2), HLA-DRA(1), HLA-DRB1(1), LCK(1), PTPRC(9)	1485531	16	8	17	2	3	7	0	2	4	0	0.214	0.666	1.000
95	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), FUT1(3), FUT2(1), FUT9(1), GCNT2(2)	952062	9	6	9	3	4	2	0	0	3	0	0.617	0.667	1.000
96	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(4), PER1(1)	1413270	12	7	12	3	1	4	0	3	3	1	0.571	0.685	1.000
97	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(6), GLI3(7), GSK3B(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), SMO(2)	2589451	29	21	29	9	6	9	0	9	5	0	0.525	0.688	1.000
98	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP8(1), CASP9(1), DFFA(2), GZMB(1), PRF1(1), SCAP(3), SREBF2(1)	2931837	24	14	22	3	3	9	1	5	6	0	0.126	0.690	1.000
99	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), IL6(2), LDLR(2)	915304	5	4	5	1	4	0	0	1	0	0	0.364	0.696	1.000
100	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	296271	3	2	3	0	0	2	0	1	0	0	0.434	0.703	1.000
101	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), CYB5R3(1), GCK(3), GFPT1(1), GNE(1), HEXA(1), HEXB(2), HK2(1), HK3(5), PGM3(2)	2908884	20	13	20	2	9	5	0	4	2	0	0.0514	0.707	1.000
102	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), GNA12(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(2)	1772911	10	8	10	2	4	2	0	2	2	0	0.432	0.710	1.000
103	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BIRC3(7), CASP8(1), TNF(1)	1295256	9	6	8	2	2	4	0	1	2	0	0.447	0.719	1.000
104	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(5), CAP1(1), CDC25C(1), GNAI1(2), GNAS(4), GNGT1(1), MAPK3(1), MYT1(5), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	3282282	32	20	32	8	11	9	2	7	3	0	0.244	0.743	1.000
105	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT5(2), FUT1(3), FUT2(1), FUT3(2)	1160693	10	7	10	3	5	2	0	1	2	0	0.673	0.744	1.000
106	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	261192	1	1	1	0	0	0	0	1	0	0	0.767	0.745	1.000
107	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(2), HDAC9(2), MEF2A(2), YWHAH(2)	1078865	10	9	12	3	0	5	0	2	3	0	0.614	0.753	1.000
108	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(2), APOBEC4(2)	1276694	9	6	9	2	3	3	0	1	2	0	0.445	0.754	1.000
109	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(37), ATR(10), CCNA1(2), CDK4(1), CDKN1B(2), CDKN2A(2), GSK3B(1), RB1(16), TGFB2(4), TP53(109)	5177173	188	100	146	37	50	36	5	56	39	2	0.0136	0.757	1.000
110	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(1)	642691	3	3	4	0	0	1	0	1	1	0	0.483	0.768	1.000
111	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT2(5), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(5)	2444696	19	13	19	3	9	5	0	5	0	0	0.136	0.776	1.000
112	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(3), G6PD(2), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GSS(1), GSTA2(1), GSTA3(1), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(3), IDH2(1)	3090172	22	17	22	5	4	7	1	7	3	0	0.385	0.778	1.000
113	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(4), MARS2(1), MAT2B(1), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(2)	2049382	17	10	17	4	2	6	0	4	5	0	0.552	0.780	1.000
114	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), CSF1(1), CSF3(1), IL2(1), IL6(2), IL7(1), IL8(1), IL9(1)	1066240	9	5	9	3	5	4	0	0	0	0	0.545	0.784	1.000
115	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(1), FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), RAF1(3), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1)	4587570	105	51	96	24	13	27	2	55	5	3	0.198	0.786	1.000
116	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(3), SNCAIP(2), UBE2E2(1)	1110643	9	7	9	4	3	5	0	1	0	0	0.774	0.786	1.000
117	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA7(1), PSMB3(1), PSMB8(3)	1474750	7	5	7	0	0	6	1	0	0	0	0.172	0.791	1.000
118	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(1), RAB5A(1), RAB9A(1)	716188	5	3	5	1	1	1	0	2	1	0	0.578	0.795	1.000
119	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(2), IGF1R(5), IRS1(4), MAP2K1(2), MAPK3(1), PIK3CA(56), PIK3R1(9), RAF1(3), SHC1(1), SOS1(5), YWHAH(2)	3114678	90	50	81	24	9	20	1	52	6	2	0.450	0.807	1.000
120	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD3G(1), CD58(1), CD8A(1), CSF3(1), IL6(2), IL8(1)	1119323	8	5	8	2	4	1	0	2	1	0	0.534	0.809	1.000
121	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB4(5), ABCC1(5), ABCC3(1)	2376859	17	10	17	4	5	6	1	4	1	0	0.282	0.816	1.000
122	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	FOS(1), GRB2(2), JAK1(2), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PDGFRA(8), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2)	6018964	116	57	107	25	17	31	3	55	7	3	0.109	0.818	1.000
123	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOC(2)	631920	3	2	3	0	2	0	0	1	0	0	0.415	0.828	1.000
124	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	FOS(1), GRB2(2), INSR(1), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), PTPN11(10), RAF1(3), RASA1(4), SHC1(1), SLC2A4(1), SOS1(5)	4224129	106	52	97	26	13	25	2	57	7	2	0.245	0.831	1.000
125	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(8), GOT1(1)	1348548	11	6	11	3	3	3	0	2	3	0	0.584	0.835	1.000
126	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(1), CTH(1), MUT(1)	803468	4	3	4	2	1	2	0	0	1	0	0.880	0.837	1.000
127	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(6), ACACB(3), OXSM(4)	2159914	13	11	12	3	3	2	0	5	3	0	0.492	0.840	1.000
128	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(2), GNAQ(1), ITPKB(1)	914798	4	3	4	1	0	1	0	2	1	0	0.644	0.846	1.000
129	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), SQLE(1)	493950	2	2	3	0	0	2	0	0	0	0	0.588	0.849	1.000
130	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), MPO(4), PRDX6(1), TPO(7)	1334550	14	11	14	4	6	5	1	1	1	0	0.492	0.849	1.000
131	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(1), CSK(2), GRB2(2), PRKCA(3), PTPRA(1)	1584281	9	7	9	2	3	5	0	1	0	0	0.435	0.856	1.000
132	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	IL8(1)	262118	1	1	1	0	0	1	0	0	0	0	0.769	0.857	1.000
133	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(2), KERA(2), LUM(2)	621410	7	5	7	3	3	1	0	3	0	0	0.781	0.859	1.000
134	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), DFFA(2), GZMB(1), LMNA(1), LMNB1(2), LMNB2(1), PRF1(1)	3280927	28	13	26	4	6	10	1	4	7	0	0.159	0.864	1.000
135	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), UGDH(1)	1382946	9	5	9	2	1	3	1	2	2	0	0.466	0.864	1.000
136	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(14), CREB3(1), CREB5(3), RAF1(3), SNX13(1), TERF2IP(1)	1904127	24	18	24	7	4	5	2	12	1	0	0.565	0.864	1.000
137	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(2), UXS1(1)	831311	5	3	6	0	0	2	0	2	1	0	0.300	0.867	1.000
138	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), SHC1(1), SOS1(5)	1484162	8	7	8	2	0	3	0	5	0	0	0.610	0.868	1.000
139	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2), SHMT1(1)	828352	3	3	3	2	0	1	0	0	2	0	0.978	0.868	1.000
140	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1)	2095465	10	7	10	1	4	4	0	2	0	0	0.189	0.879	1.000
141	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(5), C6(3), C7(1), C8A(3), C9(1)	2144658	15	9	17	3	5	6	0	2	2	0	0.324	0.881	1.000
142	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(1), CDC42(1), CHUK(4), MAP2K1(2), MAPK3(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RAF1(3), RALA(1), RALBP1(2), RALGDS(2), RELA(1), RHOA(1)	3166884	87	50	78	23	12	16	2	50	5	2	0.408	0.886	1.000
143	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	55	APC(153), AXIN1(2), CTNNB1(21), DVL2(1), DVL3(2), FBXW2(1), FZD1(2), FZD10(2), FZD3(3), FZD6(5), FZD7(1), FZD9(1), GSK3B(1), LDLR(2), MAPK10(4), MAPK9(3), PLAU(1), PPP2R5C(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RHOA(1), SFRP4(4), TCF7(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1)	9049837	243	111	207	55	22	42	1	64	75	39	0.0372	0.888	1.000
144	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(2), GAD1(2), GGT1(2)	950667	6	5	6	3	2	2	0	0	2	0	0.905	0.888	1.000
145	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(7), JAK3(4), MAPK3(1)	1951625	14	12	14	7	0	3	0	6	3	2	0.974	0.893	1.000
146	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), METTL2B(1), METTL6(3), PCYT1A(1), PCYT1B(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3)	2285670	14	10	14	4	5	4	0	3	2	0	0.455	0.898	1.000
147	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CDKN2A(2), PRB1(2)	1438828	10	6	10	7	2	1	0	2	5	0	0.966	0.901	1.000
148	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(3), ACADS(1), ECHS1(1), HADHA(2)	915561	9	6	9	4	3	2	0	0	4	0	0.842	0.904	1.000
149	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), TAT(2)	471862	3	1	3	2	0	2	0	0	1	0	0.892	0.906	1.000
150	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(1), CFLAR(1)	648979	3	2	3	0	0	1	0	1	1	0	0.632	0.907	1.000
151	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(13), EP300(14), NCOA3(7), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RARA(1)	3505195	45	24	43	10	11	11	2	12	9	0	0.215	0.911	1.000
152	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), MAPK8(6), PLCG1(2), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1)	3652147	33	20	33	8	7	7	1	16	1	1	0.421	0.913	1.000
153	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(1), GALNT12(1), GALNT13(1), GALNT14(1), GALNT2(5), GALNT5(7), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(2), OGT(2), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(5)	5565557	46	24	45	9	13	17	0	14	2	0	0.122	0.914	1.000
154	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(3), FSHB(2), FSHR(3), GNAS(4), XPO1(2)	1531736	19	17	19	6	6	2	3	6	2	0	0.592	0.916	1.000
155	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ESR1(1), GREB1(5), HSPB2(1), MTA3(1), TUBA8(1)	1533189	9	7	10	2	3	3	0	2	1	0	0.430	0.916	1.000
156	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ARG2(1), ASL(2), CKB(1), CKM(1), CKMT2(4), CPS1(8), NAGS(1), OAT(1), ODC1(3), OTC(3)	2950251	26	12	26	6	10	6	1	5	4	0	0.261	0.921	1.000
157	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(9), IL6(2), IL9(1), TGFB2(4)	1441978	17	11	16	6	3	8	0	4	2	0	0.640	0.922	1.000
158	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(153), AR(6), BRAF(14), DAG1(2), EGFR(11), GNA15(1), GNAI1(2), GNAQ(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), MAPK10(4), MAPK14(1), PHKA2(4), PIK3CA(56), PIK3CD(1), PIK3R1(9), RAF1(3)	8633690	286	113	248	65	23	36	2	108	75	42	0.0607	0.922	1.000
159	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(2)	950094	7	3	7	2	4	1	1	0	1	0	0.481	0.922	1.000
160	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(2)	950094	7	3	7	2	4	1	1	0	1	0	0.481	0.922	1.000
161	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(2), B4GALT5(1), FUT8(1), ST3GAL1(1)	1308066	6	6	6	2	3	1	0	1	1	0	0.687	0.924	1.000
162	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(3), ESRRA(9), HDAC5(1), MEF2A(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SLC2A4(1), YWHAH(2)	3352393	28	19	23	8	7	7	0	4	10	0	0.680	0.926	1.000
163	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), GGPS1(1), SQLE(1)	689259	3	2	4	1	0	3	0	0	0	0	0.749	0.927	1.000
164	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	FOS(1), GRB2(2), MAP2K1(2), MAPK3(1), MAPK8(6), NGFR(1), PIK3CA(56), PIK3R1(9), PLCG1(2), RAF1(3), SHC1(1), SOS1(5)	3186573	89	48	80	22	10	20	2	51	4	2	0.337	0.928	1.000
165	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ACTR2(1), ACTR3(1), ARPC2(1), CDC42(1), WASF1(3), WASL(2)	1405901	11	4	11	1	4	2	0	3	2	0	0.143	0.930	1.000
166	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), HSD3B1(1), HSD3B2(1)	1146613	6	6	6	3	1	3	0	1	1	0	0.835	0.932	1.000
167	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	BAX(2), BFAR(1), BTK(1), CAD(3), CASP3(1), CASP8(1), CASP8AP2(3), CD7(2), DAXX(4), DEDD(1), DFFA(2), EGFR(11), EPHB2(1), IL8(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MET(7), NFKB1(3), NFKB2(2), NFKBIE(1), PTPN13(3), RALBP1(2), ROCK1(8), SMPD1(1), TP53(109), TPX2(1)	11299725	197	99	172	34	58	44	5	53	37	0	0.000757	0.934	1.000
168	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(2), MUSK(2), PIK3CA(56), PIK3R1(9), TERT(2), YWHAH(2)	2593821	73	44	65	21	8	16	1	41	5	2	0.646	0.935	1.000
169	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(8)	1301269	10	4	10	4	1	4	0	5	0	0	0.783	0.936	1.000
170	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ6(2)	690278	2	2	2	0	0	2	0	0	0	0	0.625	0.940	1.000
171	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(14), CREB3(1), CREB5(3), DUSP6(1), EEF2K(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), MOS(2), NFKB1(3), RAP1A(1), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(5), SOS2(2), TRAF3(2)	5061440	52	28	49	12	8	17	2	21	4	0	0.243	0.942	1.000
172	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CD3G(1), CXCR3(1), ETV5(2), IL12A(1), IL12RB2(5), IL18R1(3), JAK2(7), MAP2K6(1), MAPK14(1), MAPK8(6), STAT4(3)	3194622	32	19	32	9	3	9	1	15	3	1	0.667	0.942	1.000
173	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA7(1), PSMB3(1), PSMD1(4), PSMD12(2), PSMD13(2), PSMD2(1), PSMD6(3)	2859624	16	7	15	1	5	7	0	3	1	0	0.0620	0.944	1.000
174	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	NR3C1(3), TNF(1)	931316	4	4	3	2	0	0	0	3	1	0	0.854	0.944	1.000
175	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), AKT3(1), GRB2(2), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(1), PIK3CA(56), PIK3CD(1), SHC1(1), SOS1(5)	2563797	72	40	63	20	5	19	1	46	1	0	0.574	0.944	1.000
176	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(37), CDC25C(1), CHEK1(1), MYT1(5), YWHAH(2)	2419065	46	30	44	12	5	16	2	17	4	2	0.489	0.948	1.000
177	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), NOS1(8), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3)	4173987	41	22	41	10	18	13	0	6	3	1	0.104	0.948	1.000
178	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOC(2), FBP2(1), FPGT(3), GCK(3), GMDS(1), GMPPA(1), HK2(1), HK3(5), PFKFB1(2), PFKFB3(1), PFKM(3), PFKP(1), PMM1(2), SORD(2)	4045688	31	18	31	6	13	10	1	6	1	0	0.0849	0.949	1.000
179	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(2), FBP2(1), G6PD(2), GPI(1), H6PD(1), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TAL1(1), TKT(1)	3278698	20	15	20	4	8	7	0	4	1	0	0.172	0.950	1.000
180	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(14), CPEB1(3), EGFR(11), ERBB2(9), ERBB4(9), ETS1(4), ETS2(1), ETV6(1), FMN2(16), GRB2(2), KRAS(63), MAP2K1(2), MAPK3(1), NOTCH1(1), NOTCH2(6), NOTCH3(4), NOTCH4(5), PIWIL1(4), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(3), SOS1(5), SOS2(2), SPIRE1(2), SPIRE2(2)	8263032	179	92	118	35	20	89	2	43	25	0	0.0333	0.951	1.000
181	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1)	1353865	7	4	7	3	1	2	1	2	1	0	0.790	0.951	1.000
182	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1)	1353865	7	4	7	3	1	2	1	2	1	0	0.790	0.951	1.000
183	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1)	950968	7	6	6	4	0	2	0	3	2	0	0.907	0.952	1.000
184	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2)	1753794	11	8	11	4	8	1	1	0	1	0	0.490	0.954	1.000
185	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(1), B4GALT3(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), ST3GAL6(4)	2281431	22	13	22	5	8	4	1	5	4	0	0.325	0.955	1.000
186	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(1), CTH(1), GOT1(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), SULT1B1(1)	2143492	13	6	13	4	2	5	0	5	1	0	0.639	0.955	1.000
187	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ANKRD1(2), IFRD1(5), IL1R1(1), MYOG(1), NR4A3(2)	1772508	11	5	11	1	4	4	0	2	1	0	0.139	0.955	1.000
188	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), DFFA(2), GZMB(1), TOP2A(1), TOP2B(1)	1339637	6	5	13	2	0	3	0	2	1	0	0.767	0.956	1.000
189	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10(1), IL10RA(1), IL10RB(1), IL6(2), JAK1(2), STAT1(2), STAT5A(2), TNF(1)	2077874	13	9	13	4	5	3	0	2	2	1	0.574	0.958	1.000
190	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(5), ABCG2(5), BCHE(4), CES1(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1)	4085275	26	15	26	5	6	12	1	5	2	0	0.120	0.960	1.000
191	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	FOS(1), GRB2(2), IGF1R(5), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), PTPN11(10), RAF1(3), RASA1(4), SHC1(1), SOS1(5)	4101291	109	54	100	29	13	26	2	60	6	2	0.355	0.961	1.000
192	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), BLNK(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(3), MAPK3(1), MAPK8IP3(1), PAPPA(6), RPS6KA3(3), SHC1(1), SOS1(5), SYK(3), VAV1(2), VAV2(2), VAV3(3)	5192774	38	19	38	7	8	18	0	8	4	0	0.125	0.961	1.000
193	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2), HADHA(2)	838193	5	5	4	4	0	1	0	2	2	0	0.982	0.961	1.000
194	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(1), CR2(2), HLA-DRA(1), HLA-DRB1(1), ITGAL(3), ITGB2(2), PTPRC(9)	2313659	21	9	25	6	3	9	0	4	5	0	0.510	0.961	1.000
195	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(1), UBE2C(1), UBE2D3(1), UBE2I(1), UBE3A(6)	1741854	11	4	11	2	3	5	0	2	1	0	0.343	0.962	1.000
196	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(1), ADCY9(3), AK1(1), ARF4(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(2), PLCG1(2), PLCG2(5), PRKCA(3), SEC61A1(1), TRIM23(5)	6247478	47	29	47	10	18	11	2	13	3	0	0.0910	0.962	1.000
197	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), MPO(4), PRDX1(1), PRDX6(1), TPO(7), TYR(3)	1534444	18	14	18	5	7	5	2	2	2	0	0.435	0.963	1.000
198	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	FOS(1), MAPK14(1), MAPK8(6), NFE2L2(3), PRKCA(3)	1386831	14	7	14	3	5	4	1	3	1	0	0.313	0.964	1.000
199	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(2), PRKCA(3)	1149145	7	7	7	3	4	2	0	1	0	0	0.741	0.965	1.000
200	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(1), ALAS2(2), CPO(1), FECH(1), GATA1(1), HBB(1), HMBS(1), UROD(1)	1425802	10	6	10	2	4	4	0	1	1	0	0.377	0.965	1.000
201	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA7(1), PSMB3(1), RPN2(1), UBE2A(1), UBE3A(6)	2276875	12	5	12	1	3	8	0	1	0	0	0.140	0.966	1.000
202	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(2), NTRK1(1), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), SHC1(1), SOS1(5)	2641891	79	47	70	21	8	18	1	47	3	2	0.521	0.966	1.000
203	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3)	1403855	9	7	9	4	3	3	0	1	2	0	0.776	0.967	1.000
204	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(1), JAK1(2), JAK2(7), STAT1(2)	1471216	14	10	14	6	2	3	0	6	1	2	0.901	0.968	1.000
205	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(2), NR1H4(2)	866845	4	2	4	1	3	0	0	1	0	0	0.507	0.968	1.000
206	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(2), IL2RG(1), IRS1(4), JAK1(2), JAK3(4), SHC1(1)	2365858	14	9	14	4	2	3	0	4	4	1	0.680	0.968	1.000
207	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(1), HADHA(2), HADHB(1), HSD17B10(1), PPT2(1)	1461136	8	7	8	4	2	3	0	0	3	0	0.882	0.969	1.000
208	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(4), CSNK1D(1), NR1D1(1), PER1(1), PER2(2), PER3(2)	2824446	18	9	18	4	3	5	0	5	4	1	0.358	0.971	1.000
209	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(4), MARS2(1), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), SCLY(1), SEPHS1(2)	4047222	27	14	27	7	5	9	0	6	7	0	0.451	0.972	1.000
210	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPPL2(1), GGH(1)	863637	2	2	2	1	1	1	0	0	0	0	0.749	0.972	1.000
211	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CHN1(1), LIMK1(1), MAP3K1(3), MYLK(4), NCF2(2), PAK1(1), PDGFRA(8), PIK3CA(56), PIK3R1(9), PLD1(3), PPP1R12B(5), RALBP1(2), TRIO(2), VAV1(2), WASF1(3)	5979535	103	52	94	24	14	29	2	48	8	2	0.215	0.972	1.000
212	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(1), MNAT1(1), XPO1(2)	1503369	4	4	4	2	1	1	0	2	0	0	0.880	0.973	1.000
213	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(1), ANGPTL2(1), DAG1(2), ETFA(1), ITGA9(4), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), MAP2K1(2), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(2), PDE3B(2), PI3(1), PIK3C2G(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), RIPK3(1), RPS4X(2), SGCB(4)	7710805	112	56	111	26	18	26	1	52	11	4	0.177	0.974	1.000
214	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT2(1), FUT9(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1)	1601269	10	8	10	4	5	1	0	2	2	0	0.721	0.974	1.000
215	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR3(2), CCR4(1), CCR7(2), CD28(1), CXCR3(1), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12A(1), IL12RB2(5), IL18R1(3), IL2(1), TGFB2(4)	3493036	26	13	26	5	6	10	0	7	3	0	0.137	0.975	1.000
216	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), CAMK2D(1), GNAS(4), GRB2(2), MAPK14(1), MAPK3(1), PIK3CA(56), PIK3R1(9), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), RPS6KA5(3), SOS1(5)	4828648	100	53	91	25	17	22	3	50	6	2	0.321	0.976	1.000
217	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(13), EP300(14), FYN(2), IL2RG(1), IL7(1), IL7R(1), JAK1(2), JAK3(4), LCK(1), NMI(1), PIK3CA(56), PIK3R1(9), STAT5A(2), STAT5B(1)	4785624	108	50	97	28	14	26	3	50	12	3	0.411	0.976	1.000
218	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(2), CBS(1), CTH(1), DNMT1(8), DNMT3A(2), DNMT3B(6), MARS(4), MARS2(1), MAT2B(1), MTR(1)	2950110	28	13	28	8	12	10	1	1	4	0	0.352	0.976	1.000
219	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(5), AASDHPPT(1), AASS(3)	1252249	10	9	10	4	0	4	0	5	1	0	0.843	0.977	1.000
220	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(2), SRP68(3), SRP72(1), SRPR(2)	1320519	10	5	10	3	2	6	0	0	2	0	0.739	0.978	1.000
221	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(3), CBX3(1), CLOCK(4), CRY1(4), DNAJA1(1), ETV6(1), GFRA1(5), GSTM3(1), HSPA8(2), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(3), PER1(1), PER2(2), PPP1R3C(2), PPP2CB(2), TOB1(2), TUBB3(2), UGP2(2), ZFR(6)	6189521	48	17	48	8	8	17	0	16	6	1	0.0778	0.979	1.000
222	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), GNAI1(2), GNGT1(1), ITGAV(4), ITGB3(4), MAPK3(1), PDGFRA(8), PIK3CA(56), PIK3R1(9), PLCB1(1), PRKCA(3), SMPD1(1), SPHK1(1)	4667032	96	56	87	27	12	24	3	46	9	2	0.495	0.979	1.000
223	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(3), CD33(1), CD5(2), CD7(2), IFNA1(1), IL10(1), IL12A(1), ITGAX(2), TLR2(5), TLR4(3), TLR7(3), TLR9(4)	3128816	28	10	28	6	9	11	0	5	3	0	0.164	0.980	1.000
224	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3)	2311707	11	7	11	4	4	3	0	2	2	0	0.626	0.980	1.000
225	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), SP1(1), SP3(3)	3331951	22	16	22	6	12	3	0	3	4	0	0.345	0.982	1.000
226	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), AOC3(1), CES1(1), CES7(1), DDHD1(12), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), PLA1A(2), PRDX6(1), SH3GLB1(1)	4327754	46	25	36	11	7	13	0	12	14	0	0.540	0.983	1.000
227	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(37), CCNA1(2), CCNE2(1), CDK4(1), CDKN1B(2), CDKN2A(2), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F3(1), E2F6(3), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), MNAT1(1), MYT1(5), NACA(5), PCNA(3), POLA2(1), POLE(4), POLE2(1), RB1(16), RBL1(3), TFDP2(1), TP53(109)	11596629	214	103	169	40	57	43	6	66	40	2	0.00239	0.984	1.000
228	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFS1(2), NDUFS2(3)	1237909	6	4	6	2	3	2	0	0	1	0	0.708	0.984	1.000
229	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(2), MAPK14(1), THBS1(2)	1238686	7	4	7	3	2	3	0	2	0	0	0.783	0.984	1.000
230	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR2(1), JAK1(2), STAT1(2), STAT2(2)	1840346	8	5	8	5	1	3	0	1	2	1	0.938	0.984	1.000
231	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST6GALNAC2(1), ST6GALNAC4(1)	931278	3	3	3	2	1	2	0	0	0	0	0.829	0.985	1.000
232	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), PDE6A(2), PDE6C(2), SLC6A13(1), TF(5)	5670315	29	17	36	5	8	11	0	5	4	1	0.0884	0.985	1.000
233	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(7), JAK3(4), PTPRU(6), REG1A(2)	2239579	21	16	21	8	8	3	0	6	2	2	0.835	0.987	1.000
234	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD3G(1), CD8A(1), ITGAL(3), ITGB2(2), PTPRC(9)	1804762	18	9	18	6	4	7	0	2	5	0	0.531	0.987	1.000
235	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), PRKCA(3), TGM2(2)	840874	7	4	7	2	4	3	0	0	0	0	0.392	0.988	1.000
236	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(2)	1216574	6	2	6	0	0	4	0	2	0	0	0.224	0.988	1.000
237	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPN2(2), EP300(14), NFATC1(2), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3)	3880987	30	20	30	8	12	7	0	5	6	0	0.310	0.988	1.000
238	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	MAP2K3(3), MAPK14(1), NFATC1(2), NFATC2(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	1748308	18	14	18	9	7	4	1	4	2	0	0.826	0.989	1.000
239	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(1), EGFR(11), RAB5A(1), TF(5), TFRC(2)	2225766	24	16	24	9	6	7	0	9	2	0	0.747	0.989	1.000
240	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), TAT(2), TYR(3)	838749	6	4	6	4	1	2	1	1	1	0	0.923	0.989	1.000
241	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(9), MAP2(9), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAR2A(1), PRKAR2B(2), PRKCE(2)	3143960	26	17	24	8	6	7	0	9	4	0	0.707	0.990	1.000
242	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	CHST11(2), CHST12(2), PAPSS1(1), PAPSS2(2), SULT1E1(1), SULT2A1(2)	1643331	10	5	10	3	3	4	0	3	0	0	0.571	0.990	1.000
243	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD3G(1), ITGAL(3), ITGB2(2), PTPRC(9)	1921983	17	8	17	6	3	7	0	2	5	0	0.600	0.991	1.000
244	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	2914484	13	8	13	3	2	6	0	3	2	0	0.409	0.991	1.000
245	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(2), JAK2(7)	1785790	12	9	12	9	1	4	0	5	0	2	0.993	0.991	1.000
246	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(2), JAK1(2), JAK2(7)	1785790	12	9	12	9	1	4	0	5	0	2	0.993	0.991	1.000
247	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	FAU(1), MRPL13(2), RPL10A(1), RPL11(2), RPL19(1), RPL28(1), RPL6(2), RPL7(1), RPL9(1), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(2), RPS6(1)	3388037	19	12	19	4	2	6	1	8	2	0	0.432	0.991	1.000
248	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(2), FBP2(1), G6PD(2), GPI(1), H6PD(1), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TKT(1), TKTL1(1), TKTL2(3)	3870101	23	17	23	6	8	8	1	5	1	0	0.280	0.992	1.000
249	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CYP2C19(1), CYP2C9(3), DHRS2(1), ECHS1(1), EHHADH(2), ESCO1(6), ESCO2(5), HADHA(2), MYST3(6), MYST4(8), SH3GLB1(1)	5212221	44	20	42	11	7	15	1	16	5	0	0.395	0.992	1.000
250	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), AGMAT(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AMD1(1), AOC3(1), ARG2(1), ASL(2), ASS1(1), CPS1(8), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(3), SAT1(1), SAT2(1)	5020824	41	21	40	11	13	12	1	7	8	0	0.277	0.992	1.000
251	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(3), FYN(2), LRP8(4), RELN(12), VLDLR(2)	2430400	24	14	24	9	6	11	1	4	2	0	0.724	0.992	1.000
252	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP5(8), ARHGAP6(1), ARHGEF1(2), ARHGEF11(4), ARPC2(1), BAIAP2(1), LIMK1(1), MYLK(4), OPHN1(4), PIP5K1B(1), PPP1R12B(5), ROCK1(8), TLN1(2), VCL(1)	7880187	45	24	42	8	9	11	0	15	10	0	0.114	0.993	1.000
253	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), FOS(1), GNAI1(2), GNAQ(1), GNAS(4), GNGT1(1), MAP2K1(2), MAPK3(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), RAF1(3), RPS6KA3(3)	5578735	50	30	50	12	21	10	2	11	6	0	0.134	0.993	1.000
254	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(2), CBS(1), CTH(1), DNMT1(8), DNMT3A(2), DNMT3B(6), MARS(4), MARS2(1), MAT2B(1), MTAP(1), MTR(1), TAT(2)	3468659	32	13	32	9	12	14	1	1	4	0	0.328	0.993	1.000
255	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	137	APC(153), AXIN1(2), AXIN2(3), BTRC(4), CACYBP(1), CAMK2D(1), CER1(2), CHD8(2), CREBBP(13), CSNK1A1L(1), CTBP2(1), CTNNB1(21), CUL1(1), DAAM1(2), DAAM2(5), DKK1(1), DKK2(3), DKK4(3), DVL2(1), DVL3(2), EP300(14), FBXW11(1), FZD1(2), FZD10(2), FZD3(3), FZD4(1), FZD6(5), FZD7(1), FZD9(1), GSK3B(1), LRP6(10), MAP3K7(2), MAPK10(4), MAPK8(6), MAPK9(3), MMP7(2), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPARD(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRICKLE1(6), PRICKLE2(4), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PSEN1(1), RBX1(1), RHOA(1), ROCK1(8), ROCK2(5), RUVBL1(2), SENP2(1), SFRP1(1), SFRP2(2), SFRP4(4), SMAD2(7), SMAD3(5), SMAD4(25), TBL1X(1), TCF7(3), TCF7L1(1), TCF7L2(13), TP53(109), VANGL1(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1)	24995909	532	121	451	97	114	106	6	136	131	39	3.29e-07	0.994	1.000
256	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	679251	1	1	1	1	0	1	0	0	0	0	0.952	0.994	1.000
257	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), AKR1D1(1), CYP11B1(4), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), SULT2A1(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1)	4588575	23	16	23	5	5	11	0	4	3	0	0.245	0.994	1.000
258	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1)	2844682	25	16	25	8	5	5	0	13	1	1	0.700	0.994	1.000
259	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), CYP2E1(2), NR1I3(2), PTGS1(1), PTGS2(1)	921354	7	6	7	4	4	1	0	1	1	0	0.867	0.994	1.000
260	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(4), CLTA(1), CLTB(1), COPA(1), GBF1(2), GPLD1(4), KDELR2(1)	2845724	14	7	14	4	6	3	0	3	2	0	0.502	0.995	1.000
261	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	14	B3GNT2(1), B4GALT1(1), B4GALT3(2), CHST1(1), CHST2(2), CHST4(2), FUT8(1), ST3GAL1(1)	1771665	11	9	11	5	6	1	1	1	2	0	0.785	0.995	1.000
262	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2)	1336344	9	7	8	5	1	3	0	3	2	0	0.933	0.995	1.000
263	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(2), HADHA(2), HSD17B10(1), SIRT1(1), SIRT2(1), SIRT5(2), VNN2(1)	2030764	11	8	10	6	1	3	0	3	4	0	0.940	0.995	1.000
264	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRB(1), CP(6), CPOX(1), EPRS(4), FECH(1), HCCS(2), HMBS(1), HMOX2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UROD(1)	4644381	27	17	27	5	5	13	0	6	3	0	0.205	0.995	1.000
265	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(2), MBTPS1(3), SCAP(3), SREBF2(1)	1836476	9	4	9	3	3	2	0	3	1	0	0.562	0.995	1.000
266	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CSNK1D(1), DRD2(2), GRM1(5), PLCB1(1), PPP3CA(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2)	2656434	22	15	22	8	10	4	1	4	3	0	0.565	0.995	1.000
267	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(5), ARHGEF1(2), F2(1), GNA12(1), GNAI1(2), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(56), PIK3R1(9), PLCB1(1), PPP1R12B(5), PRKCA(3), ROCK1(8)	4353911	97	54	88	25	14	23	1	47	10	2	0.393	0.995	1.000
268	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(2), PTPRU(6), REG1A(2), STAT1(2), STAT2(2)	2115965	14	11	14	6	9	2	0	1	1	1	0.749	0.996	1.000
269	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(2), FUT1(3), FUT2(1), FUT9(1), HEXA(1), HEXB(2), NAGA(1), ST3GAL1(1)	1712522	13	8	13	5	7	1	0	3	2	0	0.657	0.996	1.000
270	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), DHRS2(1), ESCO1(6), ESCO2(5), MYST3(6), MYST4(8), SH3GLB1(1)	4137342	38	22	36	10	6	13	0	14	5	0	0.442	0.996	1.000
271	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(6), ACACB(3), ACADM(3), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ALDH7A1(2), ECHS1(1), EHHADH(2), HADHA(2), HIBCH(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), MCEE(2), MUT(1), PCCA(6), PCCB(1), SUCLA2(3), SUCLG1(1)	6985794	53	24	52	11	9	18	1	15	10	0	0.174	0.996	1.000
272	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT2(1), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1)	1463516	9	9	8	7	1	4	0	2	2	0	0.983	0.996	1.000
273	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(4), FOS(1), IKBKB(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(6), MYD88(1), NFKB1(3), RELA(1), TLR10(3), TLR2(5), TLR3(2), TLR4(3), TLR6(2), TLR7(3), TLR9(4)	6044138	54	21	54	14	14	21	2	13	3	1	0.265	0.996	1.000
274	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), FH(1), IDH1(3), IDH2(1), SUCLA2(3)	1561900	9	9	9	7	1	3	0	4	1	0	0.989	0.996	1.000
275	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(2), JAK2(7), PTPRU(6), REG1A(2), STAT1(2)	1980539	21	16	21	8	10	3	0	6	0	2	0.781	0.996	1.000
276	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(1), ACPP(1), ENPP3(2), TYR(3)	1697709	7	6	7	5	2	1	1	1	1	1	0.962	0.997	1.000
277	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(4), ACTN2(4), BCAR1(1), BCR(1), CAV1(1), CSK(2), FYN(2), GRB2(2), ITGB1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MAPK8(6), PPP1R12B(5), RAF1(3), RAP1A(1), ROCK1(8), SHC1(1), SOS1(5), TLN1(2), VCL(1), ZYX(3)	7521569	59	27	59	10	15	19	1	17	7	0	0.0370	0.997	1.000
278	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2)	2193948	16	8	15	6	1	5	1	5	4	0	0.738	0.997	1.000
279	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(3), ITGAM(1), ITGB2(2), SELE(2)	1603012	9	7	11	5	2	5	0	0	2	0	0.822	0.997	1.000
280	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C2(1), AKR1C3(2), AKR1C4(2), ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(1), CYP3A43(3), CYP3A7(2), GSTA2(1), GSTA3(1), GSTA5(2), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2)	9548730	71	33	67	15	9	22	1	23	16	0	0.157	0.997	1.000
281	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	4	AOX1(3), PSAT1(1)	802966	4	1	4	1	0	3	0	0	1	0	0.791	0.997	1.000
282	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(3)	851050	5	5	5	3	0	1	0	3	1	0	0.925	0.997	1.000
283	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), CXCR4(1), GNAI1(2), GNAQ(1), GNGT1(1), MAP2K1(2), MAPK3(1), NFKB1(3), PIK3C2G(2), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RELA(1)	4430162	88	52	80	25	14	20	1	45	6	2	0.543	0.997	1.000
284	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(6), ITGAL(3), ITGB1(1), ITGB2(2), SELE(2)	2035867	15	8	15	6	1	9	0	2	3	0	0.763	0.997	1.000
285	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1)	1751734	7	5	8	3	3	2	0	2	0	0	0.755	0.997	1.000
286	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), ALAS2(2), CPOX(1), FECH(1), HMBS(1), UROD(1)	1346499	8	5	8	2	4	2	0	2	0	0	0.578	0.997	1.000
287	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD3G(1), CXCR3(1), IL12A(1), IL12RB2(5), JAK2(7), STAT4(3)	2543566	19	14	19	6	1	4	0	12	1	1	0.791	0.997	1.000
288	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(2), JAK2(7), MAP2K1(2), MAPK3(1), MPL(4), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2), STAT5B(1), THPO(1)	5186677	106	52	97	26	15	25	1	57	5	3	0.322	0.997	1.000
289	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(1), JAK1(2), JAK2(7), JAK3(4), STAT1(2), STAT5A(2), STAT5B(1)	3050502	19	15	19	8	2	5	0	7	3	2	0.913	0.998	1.000
290	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	CBL(7), CFLAR(1), FOS(1), GRB2(2), IL2RA(3), IL2RB(1), IL2RG(1), IRS1(4), JAK1(2), JAK3(4), MAPK3(1), NMI(1), PIK3CA(56), PIK3R1(9), RAF1(3), SHC1(1), SOS1(5), STAT5A(2), STAT5B(1), SYK(3)	5852771	108	49	99	27	15	25	1	53	11	3	0.358	0.998	1.000
291	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(3), CKM(1), GPT(1), LDHA(4), LDHB(3), MAPK14(1), NCL(2)	1499594	15	12	15	6	4	6	0	5	0	0	0.767	0.998	1.000
292	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), UGDH(1), UGP2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2)	4350842	26	12	26	4	2	13	0	7	4	0	0.137	0.998	1.000
293	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(5), POLA2(1), POLB(2), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLG(1), POLH(3), POLI(7), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM2(1), REV1(3), REV3L(9), RFC5(2)	7033599	52	25	50	10	12	18	0	9	12	1	0.243	0.998	1.000
294	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(4), CDK5(1), CSNK1D(1), GSK3B(1), MAPT(1)	1350858	8	6	7	4	4	1	0	3	0	0	0.809	0.998	1.000
295	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C9(1)	3468902	24	11	26	6	7	10	0	5	2	0	0.367	0.998	1.000
296	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(1), RDH12(1)	804597	2	1	2	1	1	1	0	0	0	0	0.778	0.998	1.000
297	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(7), AR(6), ESR1(1), ESRRA(9), HNF4A(4), NPM1(1), NR0B1(1), NR1D1(1), NR1D2(3), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR3C1(3), NR4A2(3), PGR(1), PPARD(1), RARA(1), RARB(2), ROR1(4), RORC(1), RXRB(1), RXRG(1), VDR(1)	6741368	57	27	50	12	16	10	0	19	12	0	0.200	0.998	1.000
298	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), CSF3(1), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IL10(1), IL12A(1), IL2(1), IL6(2), IL7(1), IL8(1), TGFB2(4), TNF(1)	2188764	17	7	18	6	5	7	0	2	3	0	0.641	0.998	1.000
299	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IL10(1), IL12A(1), IL16(4), IL2(1), IL6(2), IL8(1), IL9(1), TNF(1)	1666062	13	4	13	7	3	7	0	1	2	0	0.885	0.998	1.000
300	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	ERCC3(1), GTF2B(1), GTF2F2(1), GTF2H1(2), MNAT1(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3B(6), POLR3E(3), POLR3K(1), TAF12(1), TAF5(2), TAF6(1), TAF7(1), TAF9(1)	6077764	34	18	34	6	13	10	0	4	7	0	0.112	0.998	1.000
301	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(1), LPO(1), MPO(4), PRDX1(1), PRDX6(1), SHMT1(1), TPO(7)	1882215	18	13	18	7	6	6	1	2	3	0	0.698	0.998	1.000
302	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(6), PAK1(1), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5)	4757676	40	24	40	10	8	12	2	15	3	0	0.338	0.998	1.000
303	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(2), FUCA1(2), FUCA2(1), HEXA(1), HEXB(2), LCT(7), MAN2C1(1), MANBA(1)	2613226	17	11	17	6	6	3	0	4	4	0	0.677	0.999	1.000
304	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR1(1), GOSR2(1), SNAP25(1), STX11(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX5(1), STX7(1), STX8(2), VAMP3(1), VAMP4(1), YKT6(1)	2734022	16	6	16	4	5	5	0	3	3	0	0.432	0.999	1.000
305	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	ACHE(2), CHAT(1), DBH(1), GAD1(2), HDC(6), MAOA(2), PAH(2), SLC18A3(1), TPH1(2)	2204404	19	15	19	9	5	10	0	2	2	0	0.865	0.999	1.000
306	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(1), LPO(1), MPO(4), MTHFR(1), PRDX6(1), SHMT1(1), TPO(7)	1868579	18	13	18	6	7	6	1	2	2	0	0.595	0.999	1.000
307	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C8B(1), C9(1), MASP1(4)	4059879	29	14	31	6	9	12	0	6	2	0	0.193	0.999	1.000
308	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(3), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(2), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(2), ATP7B(2), NDUFA4(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(2), SHMT1(1)	6710523	38	24	37	9	7	15	0	13	3	0	0.268	0.999	1.000
309	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), FOS(1), GNAQ(1), MAPK14(1), MAPK8(6), PLCG1(2), PRKCA(3)	2351619	15	10	15	5	5	4	1	4	1	0	0.633	0.999	1.000
310	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(4), CREBBP(13), DUSP1(1), EP300(14), IKBKB(2), IL1B(1), IL8(1), MAP2K3(3), MAP2K6(1), MAP3K7(2), MAPK14(1), MYD88(1), NFKB1(3), NR3C1(3), RELA(1), TGFBR1(3), TGFBR2(2), TLR2(5), TNF(1)	4940131	62	30	59	17	14	10	3	25	10	0	0.389	0.999	1.000
311	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(6), CPT1A(3), LEPR(6), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKAG1(1), PRKAG2(1)	2589141	25	15	25	8	9	6	0	8	2	0	0.658	0.999	1.000
312	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1S(3), C2(4), C3(2), C4B(2), C5(5), C6(3), C7(1), C8A(3), C9(1), MASP1(4)	4137516	28	14	30	7	9	11	0	6	2	0	0.306	0.999	1.000
313	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(4), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF13B(1), TNFSF13B(1), TRAF3(2), TRAF5(2)	2362416	21	10	21	8	5	5	1	7	3	0	0.797	0.999	1.000
314	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), AKR1D1(1), CYP11B1(4), CYP19A1(3), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), STS(1), SULT1E1(1), SULT2A1(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2)	8106283	49	25	49	12	10	21	0	11	7	0	0.181	0.999	1.000
315	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(3), CAMKK2(1)	1953290	9	5	9	3	1	5	0	2	1	0	0.705	0.999	1.000
316	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(2), AKT2(1), AKT3(1), APAF1(4), ATM(37), BAX(2), BIRC2(2), BIRC3(7), CAPN2(2), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(2), IRAK3(2), IRAK4(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RELA(1), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(1), TP53(109)	13819297	298	104	247	56	73	70	6	99	46	4	0.000624	0.999	1.000
317	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(2), BDKRB2(2), CAV1(1), CHRNA1(3), FLT1(9), FLT4(2), KDR(4), NOS3(2), PDE3A(2), PDE3B(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKG1(6), PRKG2(2), RYR2(16)	6070893	63	38	69	18	13	15	1	27	7	0	0.366	0.999	1.000
318	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(7), PGM1(2), PYGL(2), PYGM(2)	2239402	13	9	13	5	8	2	0	2	1	0	0.663	0.999	1.000
319	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2B(1), GTF2F1(2), NCOA1(2), NCOA2(2), NCOA3(7), NCOR2(6), POLR2A(2), RARA(1)	3932288	25	16	25	8	9	8	0	4	4	0	0.649	0.999	1.000
320	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(1), CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SPN(2), TGFB2(4), TNF(1), TNFRSF8(1), TNFSF8(2)	2136358	17	12	17	8	4	6	0	5	2	0	0.817	0.999	1.000
321	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), AKT3(1), GRB2(2), IARS(1), IL13RA1(1), IL2RG(1), INPP5D(2), JAK1(2), JAK2(7), JAK3(4), PI3(1), PIK3CA(56), PPP1R13B(1), SERPINA4(5), SHC1(1), SOS1(5), SOS2(2)	6105804	93	46	84	23	8	24	1	53	5	2	0.407	1.000	1.000
322	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(1), ALAS2(2), BLVRB(1), COX15(3), CP(6), CPOX(1), EPRS(4), FECH(1), FTMT(1), HCCS(2), HMBS(1), HMOX2(2), MMAB(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2), UROD(1)	6952068	48	23	48	9	10	23	0	10	5	0	0.0965	1.000	1.000
323	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(2), ATF2(1), EGFR(11), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), MEF2A(2), PAK1(1), PRKCA(3), RAF1(3), SHC1(1), SOS1(5)	5740220	51	29	52	13	9	15	1	22	4	0	0.331	1.000	1.000
324	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(4), PGAP1(3), PIGG(3), PIGK(2), PIGM(2), PIGN(1), PIGO(2), PIGP(1), PIGS(2), PIGT(2), PIGU(1), PIGV(2), PIGX(2)	3987704	28	13	29	9	6	13	0	4	5	0	0.616	1.000	1.000
325	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1)	4032729	23	11	23	3	10	10	0	2	1	0	0.0667	1.000	1.000
326	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), CHIT1(2), CMAS(3), CYB5R1(2), CYB5R3(1), GFPT1(1), GFPT2(1), GNE(1), HEXA(1), HEXB(2), HK2(1), HK3(5), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), NANS(1), NPL(1), PGM3(2)	4915368	30	18	30	9	13	8	1	5	3	0	0.433	1.000	1.000
327	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT2(1), AKT3(1), GRB2(2), GSK3B(1), IRS1(4), JAK1(2), JAK3(4), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PPP1R13B(1), RAF1(3), SHC1(1), SOS1(5), SOS2(2)	5818174	97	49	88	25	12	23	1	50	8	3	0.379	1.000	1.000
328	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(6), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), SELE(2), SELP(2)	2579976	18	11	20	8	3	9	0	2	4	0	0.799	1.000	1.000
329	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), GRHPR(1), HAO2(1), MTHFD1(1), MTHFD1L(2)	2251392	6	5	6	6	1	2	1	1	1	0	0.990	1.000	1.000
330	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CD8A(1), CIITA(3), CTSB(3), CTSL1(2), HLA-A(3), HLA-B(3), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(8), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(2), HSPA5(2), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), KIR2DL1(1), KIR3DL1(4), KIR3DL2(1), KIR3DL3(1), KLRC3(1), KLRC4(1), LGMN(2), NFYA(2), RFX5(1), TAP1(2), TAP2(1), TAPBP(2)	7207172	69	33	63	21	14	21	2	13	13	6	0.641	1.000	1.000
331	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), EPX(1), ESCO1(6), ESCO2(5), GOT1(1), HPD(1), LPO(1), MAOA(2), MAOB(3), MPO(4), MYST3(6), MYST4(8), PRDX6(1), SH3GLB1(1), TAT(2), TPO(7)	5795968	60	30	56	16	12	21	2	13	12	0	0.437	1.000	1.000
332	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ACTR2(1), ACTR3(1), ARPC2(1), NCK1(1), NCKAP1(2), NTRK1(1), PIR(1), PSMA7(1), WASF1(3), WASF3(3), WASL(2)	2663951	19	8	19	6	6	6	0	4	3	0	0.615	1.000	1.000
333	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACSS1(1), ACSS2(1), FH(1), IDH1(3), IDH2(1), SUCLA2(3)	2321219	11	10	11	8	1	4	0	5	1	0	0.986	1.000	1.000
334	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	GNS(3), HEXA(1), HEXB(2), LCT(7), NAGLU(1)	2363965	14	8	14	7	5	4	0	3	2	0	0.842	1.000	1.000
335	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), AFMID(1), GRHPR(1), HAO2(1), MTHFD1(1), MTHFD1L(2)	2358168	7	6	7	6	2	2	1	1	1	0	0.979	1.000	1.000
336	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ECHS1(1), EHHADH(2), HADHA(2)	2071514	12	8	11	7	1	3	1	4	3	0	0.962	1.000	1.000
337	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), BIN1(3), DNM1(3), EPN1(1), EPS15(3), PICALM(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(1)	3767637	25	14	25	8	10	8	1	3	3	0	0.470	1.000	1.000
338	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	2135219	7	4	8	3	3	3	0	1	0	0	0.718	1.000	1.000
339	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(2), MAPK3(1), MEF2A(2), NTRK1(1), PIK3CA(56), PIK3R1(9), PLCG1(2), SHC1(1)	3101538	74	46	66	22	6	15	1	46	4	2	0.704	1.000	1.000
340	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(3), AGT(2), AGTR1(2), AGTR2(2), ANPEP(3), CPA3(1), CTSG(1), ENPEP(2), LNPEP(2), MAS1(1), MME(4), NLN(3), REN(2)	3576498	30	12	30	9	9	13	0	6	2	0	0.383	1.000	1.000
341	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(1), EPHB2(1), F2(1), F2RL1(1), F2RL2(2), MAP2K5(2), MAPK8(6), PLD1(3), PLD2(3), RAF1(3), RASAL1(2), TEC(2), VAV1(2)	4613190	29	13	29	8	10	9	1	8	1	0	0.410	1.000	1.000
342	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(1), F3(1), F5(7), F7(1), FGA(4), FGB(2), PROS1(3), TFPI(3)	2794202	22	8	22	8	6	7	0	7	2	0	0.713	1.000	1.000
343	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(6), ACADL(2), ACADM(3), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ECHS1(1), EHHADH(2), HADHA(2), LDHA(4), LDHB(3), MCEE(2), MUT(1), PCCA(6), PCCB(1), SUCLA2(3), SUCLG1(1)	5826630	46	23	45	12	10	14	1	12	9	0	0.415	1.000	1.000
344	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(2), FUCA1(2), FUCA2(1), HEXA(1), HEXB(2), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(1), MANBA(1)	3201897	20	13	20	9	8	3	0	5	4	0	0.826	1.000	1.000
345	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(1), ENPP3(2), NMNAT1(1), NMNAT2(1), NNMT(2), NNT(3), NT5E(1)	2582891	14	5	14	9	3	5	0	2	4	0	0.982	1.000	1.000
346	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), NFKB1(3), NFKB2(2), NFKBIE(1), PDK1(2), PHKA2(4), PIK3CB(1), PLD1(3), PLD2(3)	6926509	41	23	48	10	16	10	1	8	5	1	0.186	1.000	1.000
347	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(1), ACPP(1), ENPP3(2), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), TYR(3)	2629931	12	10	12	7	5	3	1	1	1	1	0.931	1.000	1.000
348	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP5(1), ACPP(1), ALPPL2(1), CYP3A43(3), CYP3A7(2), DHRS2(1), PON1(1), PON2(1), PON3(4)	2870024	15	11	13	6	4	5	0	4	1	1	0.716	1.000	1.000
349	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(13), EP300(14), IKBKB(2), NFKB1(3), RELA(1), TNF(1)	3810059	38	20	36	11	10	7	2	13	6	0	0.487	1.000	1.000
350	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(1), CHUK(4), GH1(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RELA(1), YWHAH(2)	2437220	77	45	68	23	10	17	1	43	4	2	0.627	1.000	1.000
351	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GRB2(2), INSR(1), IRS1(4), JAK2(7), MAP2K1(2), MAPK3(1), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SLC2A4(1), SOS1(5), STAT5A(2), STAT5B(1)	5561462	101	51	92	28	15	21	1	55	6	3	0.553	1.000	1.000
352	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG5(1), BECN1(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), PIK3C3(4), PIK3R4(1), PRKAA1(1), PRKAA2(5), ULK1(2)	3471913	22	13	22	7	4	7	0	7	4	0	0.686	1.000	1.000
353	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	62	AGTR1(2), AGTR2(2), ATP8A1(5), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), CCKAR(3), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRA(1), EDNRB(6), FPR1(3), FSHR(3), GALR1(1), GPR77(1), MC2R(3), MC3R(1), MC4R(1), MC5R(2), NMBR(1), NPY5R(2), NTSR2(1), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), PPYR1(3), SSTR1(1), SSTR2(2), SSTR4(2), TACR3(7), TRHR(2), TSHR(4)	8287907	88	45	87	28	36	24	2	23	3	0	0.165	1.000	1.000
354	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNAQ(1), GNGT1(1), HTR2C(2), PLCB1(1), TUB(1)	1237695	6	3	6	4	1	3	0	1	1	0	0.923	1.000	1.000
355	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(1), CAD(3), CANT1(1), CDA(1), CTPS(1), DCK(1), DHODH(1), DPYD(10), DPYS(2), DTYMK(1), ENTPD1(1), ENTPD4(1), ENTPD5(1), ENTPD6(1), NME6(1), NME7(3), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1), PNPT1(5), POLA1(5), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1), PRIM2(1), RFC5(2), RRM1(1), TK2(1), TXNRD2(1), TYMS(2), UMPS(1), UPB1(2), UPP2(2), UPRT(1)	13846234	91	46	91	16	25	33	2	18	13	0	0.00980	1.000	1.000
356	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B2(1), HSD17B3(2), HSD3B1(1), HSD3B2(1)	1408598	7	5	7	4	2	3	0	1	1	0	0.868	1.000	1.000
357	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(1), MAN1A1(2), MGAT1(2), MGAT4A(1), MGAT4B(1), RPN2(1)	3118050	15	12	15	9	4	3	0	4	4	0	0.952	1.000	1.000
358	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(8), FYN(2), ITGB1(1), MAP2K1(2), MAPK3(1), MYLK(4), PIK3CA(56), PIK3R1(9), RAF1(3), ROCK1(8), SHC1(1), TLN1(2)	6486884	97	52	85	27	11	23	1	53	7	2	0.517	1.000	1.000
359	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTR2(1), ACTR3(1), ANGPTL2(1), CDC42(1), FLNA(7), FLNC(3), FSCN3(1), LIMK1(1), MYH2(5), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), RHO(1), ROCK1(8), ROCK2(5), RPS4X(2), WASF1(3), WASL(2)	7459583	59	29	59	16	22	14	0	12	11	0	0.234	1.000	1.000
360	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(3), PLCB1(1), PRKCA(3), RELA(1)	1430443	9	5	9	7	6	2	0	0	1	0	0.956	1.000	1.000
361	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(1), CYP11A1(2), EDNRA(1), EDNRB(6), PLA2G4A(3), PRL(1), PTGDR(2), PTGFR(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2)	3533294	22	16	21	9	9	7	0	3	3	0	0.782	1.000	1.000
362	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(6), EPHB1(5), FYN(2), ITGB1(1), L1CAM(3), SELP(2)	2562900	21	16	24	9	8	7	0	3	3	0	0.789	1.000	1.000
363	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(1), CD79B(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5), SYK(3), VAV1(2)	6377521	50	25	50	13	15	15	1	14	5	0	0.293	1.000	1.000
364	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(7), CSF1R(1), EGF(1), EGFR(11), GRB2(2), MET(7), PDGFRA(8), PRKCA(3), SH3GLB1(1)	3453045	41	21	41	14	9	9	1	20	2	0	0.702	1.000	1.000
365	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(7), ATP4A(3), ATP5A1(3), ATP5C1(3), ATP5L(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), COX15(3), COX4I2(1), LHPP(1), NDUFA4(1), NDUFA9(1), NDUFB9(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFV3(1), PPA2(2), SDHA(2), TCIRG1(1), UQCRC2(2)	9583405	63	31	62	15	19	20	0	20	4	0	0.134	1.000	1.000
366	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(1), GNAI1(2), GNGT1(1), ITGB1(1), MAP2K1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(3), PTGS1(1), RAF1(3), SYK(3), TBXAS1(2)	4215517	24	15	24	9	8	5	0	5	6	0	0.753	1.000	1.000
367	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), APOA4(2), APOC1(1), APOC2(1), CETP(1), CYP7A1(1), HMGCR(1), LDLR(2), LIPC(1), LRP1(4), SCARB1(1)	4476099	20	9	20	7	10	5	1	2	2	0	0.557	1.000	1.000
368	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(5), C6(3), C7(1), IL6(2), IL8(1), ITGA4(6), ITGAL(3), ITGB1(1), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(3)	4164554	35	18	37	12	12	11	0	4	8	0	0.557	1.000	1.000
369	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(2), GOT1(1), PAH(2), TAT(2)	1479656	9	6	9	4	2	5	0	0	2	0	0.754	1.000	1.000
370	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(1), GNAS(4), GNGT1(1), NFKB1(3), NOS3(2), NR3C1(3), PIK3CA(56), PIK3R1(9), RELA(1)	2818906	80	48	70	25	12	16	3	43	4	2	0.697	1.000	1.000
371	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(2), AGTR1(2), AGTR2(2), BDKRB2(2), KNG1(1), NOS3(2), REN(2)	1496311	15	9	15	6	4	7	0	2	2	0	0.607	1.000	1.000
372	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP3(1), CASP8(1), INSR(1), MAGI1(4), MAGI2(7), WWP1(3), WWP2(1)	3980375	20	9	20	6	6	2	1	6	5	0	0.663	1.000	1.000
373	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2A1L(4), GTF2B(1), GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2IRD1(3), TAF1(6), TAF12(1), TAF1L(16), TAF2(3), TAF4(2), TAF4B(2), TAF5(2), TAF5L(1), TAF6(1), TAF7(1), TAF7L(2), TAF9(1)	6275731	52	30	50	14	14	12	1	15	10	0	0.409	1.000	1.000
374	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(3), ACADS(1), ACSL3(1), CPT1A(3), CPT2(1), DCI(1), EHHADH(2), HADHA(2), SLC25A20(1)	2914240	17	9	16	8	4	5	0	5	3	0	0.883	1.000	1.000
375	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSB(1), GOT1(1), PAH(2), TAT(2), YARS2(1)	1537082	9	5	9	4	1	7	0	0	1	0	0.790	1.000	1.000
376	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(2), GAB2(1), GRB2(2), INPP5D(2), KRAS(63), LAT(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MS4A2(3), NRAS(11), PDK1(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(2), PLCG2(5), PRKCA(3), PRKCE(2), RAF1(3), SOS1(5), SOS2(2), SYK(3), TNF(1), VAV1(2), VAV2(2), VAV3(3)	11743786	238	97	176	51	34	103	4	76	19	2	0.0183	1.000	1.000
377	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), CYP1A2(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP3A43(3), CYP3A7(2), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), RDH11(1), RDH12(1)	4121569	26	11	26	9	12	5	1	6	2	0	0.560	1.000	1.000
378	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ARHGEF2(1), ARPC5L(2), CDC42(1), CDH1(12), CTNNB1(21), CTTN(1), FYN(2), HCLS1(1), ITGB1(1), NCK1(1), NCK2(1), NCL(2), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(5), TLR4(3), TLR5(2), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1), WASL(2)	8427999	98	45	96	26	27	26	1	33	11	0	0.219	1.000	1.000
379	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ARHGEF2(1), ARPC5L(2), CDC42(1), CDH1(12), CTNNB1(21), CTTN(1), FYN(2), HCLS1(1), ITGB1(1), NCK1(1), NCK2(1), NCL(2), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(5), TLR4(3), TLR5(2), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1), WASL(2)	8427999	98	45	96	26	27	26	1	33	11	0	0.219	1.000	1.000
380	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT2(1), ACYP1(1), DHRS2(1), ECHS1(1), EHHADH(2), ESCO1(6), ESCO2(5), GCDH(2), HADHA(2), MYST3(6), MYST4(8), SH3GLB1(1)	4342022	36	19	34	11	6	13	0	13	4	0	0.623	1.000	1.000
381	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(4), CALCRL(2), CD97(2), CRHR1(2), CRHR2(1), ELTD1(3), EMR1(4), EMR2(4), GLP1R(5), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(4), LPHN3(4), SCTR(1), VIPR1(1)	4487325	43	23	47	15	18	13	0	8	4	0	0.409	1.000	1.000
382	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(2), GPR161(3), GPR171(1), GPR18(2), GPR34(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1)	1667795	15	8	15	6	6	3	0	3	3	0	0.585	1.000	1.000
383	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(4), ATM(37), ATR(10), BAI1(2), BAX(2), CASP3(1), CASP8(1), CASP9(1), CCNB3(7), CCNE2(1), CCNG1(1), CDK4(1), CDKN2A(2), CHEK1(1), CHEK2(3), DDB2(1), FAS(2), GTSE1(3), IGFBP3(2), MDM4(1), PTEN(47), RFWD2(1), SERPINB5(4), SERPINE1(2), SESN2(1), SESN3(1), THBS1(2), TNFRSF10B(4), TP53(109), TP53I3(2), TSC2(2), ZMAT3(3)	10416759	261	104	215	60	61	65	5	86	42	2	0.0536	1.000	1.000
384	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(37), BMPR1B(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(1), EGR1(3), FSHR(3), MLH1(6), MSH5(1), NCOR1(5), NRIP1(1), PGR(1), PRLR(2), SMPD1(1), VDR(1), ZP2(2)	5901079	69	37	67	20	13	18	3	24	9	2	0.478	1.000	1.000
385	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(4), ACTN2(4), ITGB1(1), ITGB3(4), SPTAN1(5), TLN1(2)	4678961	22	13	22	8	8	7	1	2	4	0	0.635	1.000	1.000
386	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACOX3(2), ELOVL6(1), FADS2(2), HADHA(2)	1872007	7	7	7	6	3	3	0	0	1	0	0.957	1.000	1.000
387	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(5), AASDHPPT(1), AASS(3), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), BBOX1(2), DLST(1), DOT1L(1), ECHS1(1), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(2), HADHA(2), PLOD1(1), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(3)	5874736	41	21	39	13	10	12	1	12	6	0	0.571	1.000	1.000
388	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(2), EXT2(2), EXTL2(3), EXTL3(2), GLCE(3), HS2ST1(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), NDST1(1), NDST2(1), NDST3(4)	3392649	24	14	24	9	7	7	1	7	2	0	0.681	1.000	1.000
389	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA3(2), CA5A(1), CA7(1), CA8(1), CPS1(8), CTH(1), GLUL(1), HAL(1)	3304266	16	7	16	6	5	6	0	3	2	0	0.701	1.000	1.000
390	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(2), GNAQ(1), GNAS(4), GNGT1(1), LIMK1(1), MAP2K1(2), MAPK3(1), PIK3C2G(2), PLCB1(1), PPP1R12B(5), PRKCA(3), RAF1(3), ROCK2(5)	4128496	32	20	33	10	8	7	2	5	10	0	0.673	1.000	1.000
391	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(4), CDC7(2), DIAPH2(4), GMNN(2), MCM10(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), NACA(5), PCNA(3), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), RFC1(5), RFC2(1), RFC5(2), RPA4(1), UBB(1), UBC(1)	8336337	52	27	49	12	11	20	0	15	6	0	0.267	1.000	1.000
392	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), CD3G(1), FOS(1), FYN(2), GRB2(2), LAT(1), LCK(1), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), PIK3CA(56), PIK3R1(9), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(3), PTPN7(1), RAF1(3), RASA1(4), RELA(1), SHC1(1), SOS1(5), VAV1(2)	7953906	127	62	118	30	27	33	2	54	9	2	0.119	1.000	1.000
393	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(3), IMPDH1(1), POLB(2), POLD1(2), POLG(1), RRM1(1)	2024182	10	7	10	5	4	2	0	3	1	0	0.850	1.000	1.000
394	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(1), DARS(1), EPRS(4), FARS2(2), IARS(1), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(1), QARS(1), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(1)	5674133	27	14	27	8	4	9	1	8	5	0	0.653	1.000	1.000
395	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(1), ALOX15(1), CYP4F3(1), EPX(1), GGT1(2), LPO(1), MPO(4), PLA2G4A(3), PLA2G6(2), PRDX1(1), PRDX6(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2), TPO(7)	4577993	32	21	32	10	15	7	1	2	7	0	0.503	1.000	1.000
396	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA3(2), CA5A(1), CA7(1), CA8(1), CPS1(8), CTH(1), GLUD2(2), GLUL(1), HAL(1)	3674511	18	9	18	8	5	8	0	3	2	0	0.820	1.000	1.000
397	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), LMNA(1), NFKB1(3), RELA(1), SPTAN1(5), TNFRSF10B(4), TNFSF10(1)	5556770	39	17	37	11	13	11	0	7	8	0	0.498	1.000	1.000
398	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), AOX1(3), DBH(1), DCT(5), ESCO1(6), ESCO2(5), FAH(1), GOT1(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), MYST3(6), MYST4(8), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), SH3GLB1(1), TAT(2), TPO(7), TYR(3)	9798316	86	40	81	26	13	29	3	22	19	0	0.575	1.000	1.000
399	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(1), ASL(2), ASS1(1), CKB(1), CKM(1), CKMT2(4), CPS1(8), DAO(4), EPRS(4), GLUD2(2), GOT1(1), LAP3(1), NOS1(8), NOS3(2), OAT(1), OTC(3), P4HA1(1), P4HA3(2), RARS(2), RARS2(3)	5941862	53	23	53	16	16	19	2	8	8	0	0.422	1.000	1.000
400	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT2(1), AKT3(1), CASP9(1), CDC42(1), KDR(4), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NOS3(2), NRAS(11), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCG1(2), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCA(3), PRKCG(5), PTGS2(1), RAF1(3), SH2D2A(1), SPHK1(1)	11380620	209	97	145	49	36	91	2	65	13	2	0.0516	1.000	1.000
401	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(1), CDC42(1), DAXX(4), DDIT3(1), GRB2(2), HSPB2(1), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP3K5(2), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MEF2A(2), MKNK1(2), PLA2G4A(3), RPS6KA5(3), SHC1(1), STAT1(2), TGFB2(4), TGFBR1(3)	6067967	47	22	48	14	9	15	0	17	6	0	0.504	1.000	1.000
402	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), ALDOC(2), FBP2(1), FPGT(3), GMDS(1), GMPPA(1), HK2(1), HK3(5), LHPP(1), MTMR1(1), MTMR2(1), MTMR6(2), PFKFB1(2), PFKFB3(1), PFKM(3), PFKP(1), PGM2(1), PMM1(2), RDH11(1), RDH12(1), SORD(2)	6198694	36	19	36	11	14	13	1	7	1	0	0.351	1.000	1.000
403	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT2(1), AKT3(1), BLNK(1), BTK(1), CARD11(9), CD22(2), CD72(1), CD79B(1), CHUK(4), CR2(2), FOS(1), GSK3B(1), IKBKB(2), INPP5D(2), KRAS(63), LILRB3(2), MALT1(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), NFKB2(2), NFKBIE(1), NRAS(11), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), RASGRP3(1), SYK(3), VAV1(2), VAV2(2), VAV3(3)	12115613	217	97	157	52	35	103	1	64	12	2	0.0616	1.000	1.000
404	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(4), ATF4(2), BRAF(14), CACNA1C(3), CAMK2D(1), CAMK4(3), CREBBP(13), EP300(14), GNAQ(1), GRIA1(3), GRIA2(6), GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), GRM1(5), GRM5(5), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK3(1), NRAS(11), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(3), RAP1A(1), RAPGEF3(2), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3)	16281758	229	101	178	51	43	105	4	55	20	2	0.00671	1.000	1.000
405	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), AOX1(3), DBH(1), DCT(5), FAH(1), GOT1(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(3), TAT(2), TPO(7), TYR(3)	5203396	49	30	45	18	6	16	3	10	14	0	0.833	1.000	1.000
406	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(1), EGFR(11), FOS(1), GRB2(2), JAK1(2), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), RAF1(3), RASA1(4), SHC1(1), SOS1(5), STAT1(2), STAT5A(2)	6485980	120	58	111	30	19	30	2	60	6	3	0.275	1.000	1.000
407	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNA1(1), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(2), IL1RN(1), IL6(2), IRAK3(2), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K7(2), MAPK14(1), MAPK8(6), MYD88(1), NFKB1(3), RELA(1), TGFB2(4), TNF(1)	4886545	42	13	42	13	12	13	2	11	4	0	0.534	1.000	1.000
408	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5)	2840034	16	9	15	6	3	5	0	5	3	0	0.731	1.000	1.000
409	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), AKAP10(1), AKAP11(4), AKAP12(6), AKAP3(4), AKAP4(2), AKAP5(1), AKAP6(7), AKAP7(1), AKAP8(1), AKAP9(9), ARHGEF1(2), GNA12(1), GNA14(3), GNA15(1), GNAL(1), GNAQ(1), GNAZ(2), GNG3(1), GNG4(1), GNGT1(1), IL18BP(3), ITPR1(2), KRAS(63), NRAS(11), PDE1A(2), PDE1B(1), PDE1C(2), PDE4B(4), PDE4D(2), PDE7A(1), PDE7B(2), PDE8B(3), PLCB3(1), PPP3CA(2), PPP3CC(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PRKD1(6), PRKD3(4), RHOA(1), SLC9A1(3), USP5(1)	19382234	217	90	169	48	46	109	1	35	25	1	0.00683	1.000	1.000
410	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT2(1), AKT3(1), ARHGEF11(4), CDC42(1), LPA(2), MAP2K4(4), MAP3K1(3), MAP3K5(2), MAPK8(6), NFKB1(3), NFKB2(2), NFKBIE(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(3), PLD2(3), RDX(3), ROCK1(8), ROCK2(5), SERPINA4(5)	8141239	65	27	65	19	21	22	1	13	8	0	0.485	1.000	1.000
411	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), ATIC(1), MTHFD1(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(2)	3110841	13	7	13	6	4	5	0	3	1	0	0.736	1.000	1.000
412	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), ATIC(1), MTHFD1(1), MTHFD1L(2), MTHFR(1), MTR(1), SHMT1(1), TYMS(2)	3191546	13	7	13	6	4	5	0	3	1	0	0.741	1.000	1.000
413	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(13), CDR1(3), DGKI(4), FAU(1), IL6ST(1), PIGK(2), RPL10(1), RPL11(2), RPL19(1), RPL22(1), RPL28(1), RPL5(1), RPL6(2), RPL7(1), RPL9(1), RPS14(1), RPS16(1), RPS18(1), RPS2(1), RPS3(2), RPS4X(2), RPS6(1), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB2(2), SLC36A2(3), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(1)	8506880	62	35	62	15	18	17	1	17	9	0	0.328	1.000	1.000
414	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CSK(2), DAG1(2), EPHB2(1), GRB2(2), ITPKB(1), MAP2K1(2), MAP2K2(1), NFKB1(3), NFKB2(2), NFKBIE(1), PI3(1), PIK3CA(56), PIK3CD(1), PIK3R1(9), PLCG2(5), PPP1R13B(1), RAF1(3), SERPINA4(5), SHC1(1), SOS1(5), SOS2(2), SYK(3), VAV1(2)	8483359	116	52	107	30	22	28	1	56	7	2	0.282	1.000	1.000
415	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), AKT3(1), BCR(1), BLNK(1), BTK(1), CD22(2), CR2(2), CSK(2), DAG1(2), FLOT1(1), GRB2(2), GSK3B(1), INPP5D(2), ITPR1(2), ITPR2(8), ITPR3(5), MAP4K1(1), MAPK3(1), NFATC1(2), NFATC2(2), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PLCG2(5), PPP1R13B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTPRC(9), RAF1(3), SHC1(1), SOS1(5), SOS2(2), SYK(3), VAV1(2)	11754043	144	59	142	35	31	41	1	55	13	3	0.121	1.000	1.000
416	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(3), EEF1B2(2), EEF1D(3), EEF2K(1), EIF2AK2(2), EIF2AK3(1), EIF2B2(1), EIF2B5(1), EIF2S3(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(2), EIF4G3(3), EIF5A(1), ETF1(3), PABPC3(7), PAIP1(3)	7177954	37	22	36	11	10	10	1	11	5	0	0.610	1.000	1.000
417	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(3), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), BBOX1(2), DLST(1), DOT1L(1), ECHS1(1), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(2), HADHA(2), HSD17B10(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(1), PLOD2(1), PLOD3(1), RDH11(1), RDH12(1), SETD1A(1), SETD7(2), SETDB1(1), SHMT1(1), SPCS1(1), SUV39H2(1), TMLHE(3)	9471424	56	24	54	17	18	16	1	12	9	0	0.469	1.000	1.000
418	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	CAD(3), CANT1(1), CDA(1), CTPS(1), DCK(1), DHODH(1), DPYD(10), DPYS(2), DTYMK(1), ENTPD1(1), NT5E(1), POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1), RRM1(1), TK2(1), TYMS(2), UMPS(1), UPB1(2)	9563213	56	31	55	16	13	18	2	15	8	0	0.385	1.000	1.000
419	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDH7A1(2), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), G6PC2(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGK2(1), PGM1(2), PGM3(2), PKLR(1)	9647469	71	32	67	23	21	19	2	17	12	0	0.508	1.000	1.000
420	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT2(1), AKT3(1), CARD11(9), CBL(7), CBLB(3), CD28(1), CD3D(1), CD3G(1), CD8A(1), CDC42(1), CDK4(1), CHUK(4), CTLA4(1), FOS(1), FYN(2), GRAP2(4), GRB2(2), IKBKB(2), IL10(1), IL2(1), ITK(5), KRAS(63), LAT(1), LCK(1), LCP2(1), MALT1(1), NCK1(1), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), NFKB2(2), NFKBIE(1), NRAS(11), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDK1(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCQ(1), PTPRC(9), RASGRP1(1), RHOA(1), SOS1(5), SOS2(2), TEC(2), TNF(1), VAV1(2), VAV2(2), VAV3(3)	16681566	270	99	210	61	50	120	1	81	16	2	0.0230	1.000	1.000
421	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PKLR(1)	8214854	63	32	59	22	21	14	2	15	11	0	0.630	1.000	1.000
422	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GPI(1), HK2(1), HK3(5), LDHA(4), LDHB(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGM1(2), PGM3(2), PKLR(1)	8214854	63	32	59	22	21	14	2	15	11	0	0.630	1.000	1.000
423	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(4), AMY1B(1), AMY2A(2), AMY2B(3), ENPP3(2), G6PC(1), GANAB(1), GCK(3), GPI(1), GYS1(1), GYS2(4), HK2(1), HK3(5), PGM1(2), PGM3(2), PYGL(2), PYGM(2), SI(4), UCHL1(1), UCHL3(1), UGDH(1), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(1), UXS1(1)	9780094	52	28	51	16	15	14	0	14	9	0	0.513	1.000	1.000
424	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH4A1(1), AMD1(1), AOC3(1), ARG2(1), ASL(2), CKB(1), CKM(1), CKMT2(4), CPS1(8), DAO(4), GOT1(1), MAOA(2), MAOB(3), NOS1(8), NOS3(2), OAT(1), ODC1(3), OTC(3), P4HA1(1), P4HA3(2), RARS(2)	7366444	63	26	62	21	22	18	3	9	11	0	0.465	1.000	1.000
425	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(3), ACVR1B(3), ACVR1C(2), ACVR2A(2), ACVR2B(2), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP6(2), BMP7(1), BMPR1B(1), BMPR2(3), CHRD(2), CREBBP(13), CUL1(1), DCN(2), EP300(14), FST(1), GDF5(2), GDF6(1), INHBA(4), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL1(3), RBL2(2), RBX1(1), RHOA(1), ROCK1(8), ROCK2(5), RPS6KB2(2), SMAD2(7), SMAD3(5), SMAD4(25), SMAD5(1), SMAD7(1), SMAD9(2), SMURF1(2), SMURF2(1), SP1(1), TGFB2(4), TGFBR1(3), TGFBR2(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNF(1), ZFYVE16(3), ZFYVE9(5)	16466505	175	72	169	39	47	48	2	48	29	1	0.0340	1.000	1.000
426	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPPL2(1), ASCC3(5), DDX18(1), DDX19A(1), DDX23(4), DDX4(3), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(2), EP400(4), ERCC3(1), GGH(1), IFIH1(2), MOV10L1(7), RAD54B(2), RUVBL2(2), SETX(10), SKIV2L2(2), SMARCA2(3), SMARCA5(5)	10438511	61	25	61	18	17	17	1	13	13	0	0.452	1.000	1.000
427	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(2), ACADM(3), ACOX2(1), ACOX3(2), ACSL3(1), ACSL5(1), ACSL6(1), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), CYP4A11(1), CYP7A1(1), CYP8B1(1), EHHADH(2), FABP2(1), FABP7(1), FADS2(2), GK2(3), HMGCS2(1), ME1(3), MMP1(1), OLR1(1), PCK1(3), PLTP(2), PPARD(1), RXRB(1), RXRG(1), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(4), UBC(1)	11056050	57	25	56	18	23	17	1	11	5	0	0.407	1.000	1.000
428	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(2), AGT(2), CALR(1), CAMK1(2), CAMK1G(2), CAMK4(3), CREBBP(13), F2(1), FKBP1A(1), GSK3B(1), HAND1(1), HAND2(1), MAP2K1(2), MAPK14(1), MAPK3(1), MAPK8(6), MYH2(5), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PIK3CA(56), PIK3R1(9), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RAF1(3)	8175581	135	61	124	37	26	31	4	60	12	2	0.332	1.000	1.000
429	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	241	ACVR1B(3), ACVR1C(2), AKT2(1), AKT3(1), ATF2(1), ATF4(2), BDNF(1), BRAF(14), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1F(2), CACNA1G(1), CACNA1I(4), CACNA1S(5), CACNA2D1(3), CACNA2D3(3), CACNA2D4(1), CACNB2(2), CACNB3(1), CACNB4(1), CACNG2(1), CACNG3(4), CACNG5(1), CACNG6(1), CACNG7(3), CASP3(1), CDC42(1), CHUK(4), DAXX(4), DDIT3(1), DUSP1(1), DUSP10(1), DUSP16(2), DUSP5(1), DUSP6(1), DUSP7(2), ECSIT(1), EGF(1), EGFR(11), ELK4(1), FAS(2), FGF11(1), FGF12(2), FGF13(2), FGF14(2), FGF19(1), FGF20(1), FGF23(1), FGF5(3), FGF8(1), FGFR1(2), FGFR2(11), FGFR3(1), FGFR4(1), FLNA(7), FLNB(4), FLNC(3), FOS(1), GNA12(1), GRB2(2), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(4), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K5(2), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(3), MAP4K4(1), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MAPKAPK2(1), MAPKAPK5(1), MAPT(1), MKNK1(2), MKNK2(1), MOS(2), NF1(20), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(2), NRAS(11), NTRK1(1), NTRK2(2), PAK1(1), PAK2(1), PDGFB(1), PDGFRA(8), PDGFRB(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PPM1A(1), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PPP5C(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PTPN5(1), PTPN7(1), PTPRR(5), RAF1(3), RAP1A(1), RAPGEF2(6), RASA1(4), RASA2(2), RASGRF1(3), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(1), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), RPS6KA5(3), RPS6KA6(3), RRAS2(3), SOS1(5), SOS2(2), STK4(1), STMN1(1), TAOK2(1), TGFB2(4), TGFBR1(3), TGFBR2(2), TNF(1), TP53(109), ZAK(4)	44570908	559	119	493	132	153	168	13	151	71	3	0.000183	1.000	1.000
430	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(2), ACTN1(4), ACTN2(4), ACTN4(1), APC(153), ARHGEF1(2), ARHGEF12(2), ARHGEF4(1), ARHGEF6(3), ARHGEF7(2), ARPC2(1), ARPC5L(2), BAIAP2(1), BCAR1(1), BDKRB1(1), BDKRB2(2), BRAF(14), CDC42(1), CHRM2(4), CHRM3(2), CHRM5(1), CSK(2), CYFIP1(1), DIAPH2(4), DIAPH3(2), DOCK1(2), EGF(1), EGFR(11), F2(1), FGD1(3), FGD3(1), FGF11(1), FGF12(2), FGF13(2), FGF14(2), FGF19(1), FGF20(1), FGF23(1), FGF5(3), FGF8(1), FGFR1(2), FGFR2(11), FGFR3(1), FGFR4(1), FN1(6), GIT1(1), GNA12(1), GRLF1(1), IQGAP1(7), IQGAP2(7), IQGAP3(1), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(2), ITGB1(1), ITGB2(2), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), KRAS(63), LIMK1(1), LIMK2(2), MAP2K1(2), MAP2K2(1), MAPK3(1), MOS(2), MSN(3), MYH10(2), MYH14(3), MYH9(3), MYL9(3), MYLK(4), MYLK2(1), NCKAP1(2), NCKAP1L(4), NRAS(11), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDGFB(1), PDGFRA(8), PDGFRB(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PIP5K1B(1), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), RAF1(3), RDX(3), RHOA(1), ROCK1(8), ROCK2(5), RRAS2(3), SLC9A1(3), SOS1(5), SOS2(2), SSH1(2), SSH3(1), TIAM1(8), TIAM2(2), VAV1(2), VAV2(2), VAV3(3), VCL(1), WASF1(3), WASL(2)	45247219	618	119	527	162	90	190	9	166	122	41	0.0608	1.000	1.000
431	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(37), BUB1(3), BUB1B(3), CCNA1(2), CCNB3(7), CCNE2(1), CDAN1(2), CDC14A(4), CDC14B(1), CDC25C(1), CDC6(4), CDC7(2), CDH1(12), CDK4(1), CDKN2A(2), CHEK1(1), CHEK2(3), E2F3(1), E2F6(3), EP300(14), ESPL1(1), GSK3B(1), HDAC5(1), HDAC6(2), MAD1L1(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), MPEG1(2), MPL(4), PCNA(3), PLK1(4), PRKDC(5), PTPRA(1), RB1(16), RBL1(3), SMAD4(25), TP53(109)	18428924	297	107	250	69	77	64	6	101	47	2	0.0325	1.000	1.000
432	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(4), ANAPC1(1), ANAPC4(4), ANAPC5(1), ATM(37), ATR(10), BUB1(3), BUB1B(3), CCNA1(2), CCNB3(7), CCNE2(1), CDC14A(4), CDC14B(1), CDC16(1), CDC25C(1), CDC27(5), CDC6(4), CDC7(2), CDK4(1), CDKN1B(2), CDKN2A(2), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(1), DBF4(3), E2F3(1), EP300(14), ESPL1(1), FZR1(1), GSK3B(1), MAD1L1(2), MCM3(2), MCM4(2), MCM5(3), MCM6(1), MCM7(2), PCNA(3), PLK1(4), PRKDC(5), RB1(16), RBL1(3), RBL2(2), RBX1(1), SMAD2(7), SMAD3(5), SMAD4(25), SMC1B(3), TGFB2(4), TP53(109), YWHAH(2)	22813359	336	107	287	86	81	81	8	106	58	2	0.149	1.000	1.000
433	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(4), ABLIM1(3), ABLIM3(2), ARHGEF12(2), CDC42(1), CDK5(1), CXCR4(1), DCC(6), DPYSL2(2), EFNA5(3), EFNB2(1), EFNB3(2), EPHA1(4), EPHA3(9), EPHA4(6), EPHA5(8), EPHA6(3), EPHA7(7), EPHA8(3), EPHB1(5), EPHB2(1), EPHB4(4), EPHB6(3), FES(1), FYN(2), GNAI1(2), GSK3B(1), ITGB1(1), KRAS(63), L1CAM(3), LIMK1(1), LIMK2(2), LRRC4C(3), MAPK3(1), MET(7), NCK1(1), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NGEF(2), NRAS(11), NRP1(1), NTN1(1), NTN4(3), NTNG1(3), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PLXNA1(2), PLXNA2(5), PLXNA3(2), PLXNB1(2), PLXNB3(3), PLXNC1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), RASA1(4), RGS3(3), RHOA(1), ROBO1(2), ROBO2(6), ROBO3(2), ROCK1(8), ROCK2(5), SEMA3A(4), SEMA3C(1), SEMA3D(7), SEMA3E(5), SEMA3F(1), SEMA3G(2), SEMA4A(1), SEMA4B(2), SEMA4D(1), SEMA4F(5), SEMA4G(2), SEMA5A(2), SEMA5B(4), SEMA6A(1), SEMA6B(2), SEMA6C(2), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(4), SLIT3(2), SRGAP1(2), SRGAP3(2), UNC5A(3), UNC5B(2), UNC5C(4), UNC5D(1)	30085477	333	106	290	78	98	129	3	68	35	0	0.00264	1.000	1.000
434	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(3), AKT2(1), AKT3(1), BRAF(14), CAMK2D(1), CBL(7), CBLB(3), CDKN1B(2), EGF(1), EGFR(11), ERBB2(9), ERBB3(4), ERBB4(9), GRB2(2), GSK3B(1), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), NCK1(1), NCK2(1), NRAS(11), NRG1(7), NRG2(2), NRG3(4), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PLCG2(5), PRKCA(3), PRKCG(5), RAF1(3), RPS6KB2(2), SHC1(1), SOS1(5), SOS2(2), STAT5A(2), STAT5B(1)	17211535	304	104	235	75	48	120	4	107	23	2	0.0823	1.000	1.000
435	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTN1(4), ACTN2(4), ACTN4(1), AKT2(1), AKT3(1), ASH1L(13), CASK(2), CDC42(1), CDK4(1), CGN(3), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), CTTN(1), EPB41L1(1), EPB41L3(4), EXOC4(3), GNAI1(2), HCLS1(1), IGSF5(2), INADL(3), KRAS(63), LLGL1(1), LLGL2(2), MAGI1(4), MAGI2(7), MAGI3(2), MLLT4(4), MPDZ(3), MPP5(1), MYH1(9), MYH10(2), MYH11(9), MYH13(2), MYH14(3), MYH15(6), MYH2(5), MYH3(7), MYH4(2), MYH6(7), MYH7(4), MYH7B(4), MYH8(5), MYH9(3), MYL9(3), NRAS(11), PARD3(2), PARD6A(1), PARD6G(1), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(1), PRKCZ(1), PTEN(47), RHOA(1), RRAS2(3), SPTAN1(5), TJAP1(2), TJP1(4), TJP3(1), YES1(1), ZAK(4)	31647271	347	104	297	107	72	148	2	91	33	1	0.512	1.000	1.000
436	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	BRAF(14), CASP3(1), FAS(2), FCGR3A(1), FYN(2), GRB2(2), GZMB(1), HLA-A(3), HLA-B(3), HLA-G(1), ICAM2(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), ITGAL(3), ITGB2(2), KIR2DL1(1), KIR3DL1(4), KIR3DL2(1), KLRC3(1), KLRK1(1), KRAS(63), LAT(1), LCK(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MICB(3), NCR1(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NRAS(11), PAK1(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PLCG2(5), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRF1(1), PRKCA(3), PRKCG(5), PTPN11(10), RAF1(3), SH3BP2(1), SHC1(1), SOS1(5), SOS2(2), SYK(3), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP3(1), VAV1(2), VAV2(2), VAV3(3)	18581787	285	104	218	79	45	116	4	95	21	4	0.229	1.000	1.000
437	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADRB1(2), CSNK1D(1), DRD2(2), EGF(1), EGFR(11), GJA1(4), GJD2(1), GNAI1(2), GNAQ(1), GNAS(4), GRB2(2), GRM1(5), GRM5(5), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), HTR2A(5), HTR2C(2), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR1(2), NPR2(2), NRAS(11), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PRKG1(6), PRKG2(2), RAF1(3), SOS1(5), SOS2(2), TJP1(4), TUBA1B(3), TUBA1C(3), TUBA3C(1), TUBA3D(1), TUBA3E(1), TUBA4A(3), TUBA8(1), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB2C(2), TUBB3(2), TUBB4(2), TUBB8(1)	21453459	271	101	224	63	61	122	6	60	20	2	0.00275	1.000	1.000
438	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	125	ACACA(6), ACACB(3), AKT2(1), AKT3(1), BRAF(14), CBL(7), CBLB(3), EXOC7(1), FBP2(1), FLOT1(1), G6PC(1), G6PC2(1), GCK(3), GRB2(2), GSK3B(1), GYS1(1), GYS2(4), IKBKB(2), INPP5D(2), INSR(1), IRS1(4), IRS4(6), KRAS(63), LIPE(2), MAP2K1(2), MAP2K2(1), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), MKNK1(2), MKNK2(1), NRAS(11), PCK1(3), PDE3A(2), PDE3B(2), PFKM(3), PFKP(1), PHKA1(5), PHKA2(4), PHKB(2), PHKG2(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PKLR(1), PPP1CB(1), PPP1CC(1), PPP1R3A(7), PPP1R3C(2), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCI(1), PRKCZ(1), PTPN1(1), PTPRF(2), PYGL(2), PYGM(2), RAF1(3), RHEB(1), RPS6(1), RPS6KB2(2), SHC1(1), SLC2A4(1), SOCS2(2), SOCS4(1), SORBS1(4), SOS1(5), SOS2(2), TRIP10(1), TSC1(1), TSC2(2)	25285499	332	101	266	83	64	127	5	106	28	2	0.0328	1.000	1.000
439	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ATF4(2), CACNA1C(3), CACNA1D(1), CACNA1F(2), CACNA1S(5), CAMK2D(1), CDC42(1), CGA(1), EGFR(11), FSHB(2), GNAQ(1), GNAS(4), GNRH2(1), GRB2(2), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MMP14(1), MMP2(6), NRAS(11), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(3), PLD2(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), RAF1(3), SOS1(5), SOS2(2)	20784766	234	99	188	61	53	101	6	47	26	1	0.0375	1.000	1.000
440	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), CAMK2D(1), CREB3(1), CREB3L1(1), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(21), DCT(5), DVL2(1), DVL3(2), EDNRB(6), EP300(14), FZD1(2), FZD10(2), FZD3(3), FZD4(1), FZD6(5), FZD7(1), FZD9(1), GNAI1(2), GNAQ(1), GNAS(4), GSK3B(1), KIT(22), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK3(1), MITF(5), NRAS(11), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(3), TCF7(3), TCF7L1(1), TCF7L2(13), TYR(3), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1)	17158129	275	99	213	72	49	120	6	73	27	0	0.0475	1.000	1.000
441	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	165	ADCY1(5), ADCY2(7), ADCY3(1), ADCY7(3), ADCY8(4), ADCY9(3), ADORA2A(3), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), AGTR1(2), ATP2A1(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(4), ATP2B4(5), AVPR1A(2), BDKRB1(1), BDKRB2(2), BST1(1), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1F(2), CACNA1G(1), CACNA1I(4), CACNA1S(5), CAMK2D(1), CAMK4(3), CCKAR(3), CCKBR(4), CD38(1), CHRM2(4), CHRM3(2), CHRM5(1), CHRNA7(1), CYSLTR2(2), EDNRA(1), EDNRB(6), EGFR(11), ERBB2(9), ERBB3(4), ERBB4(9), GNA14(3), GNA15(1), GNAL(1), GNAQ(1), GNAS(4), GRIN2A(7), GRIN2C(2), GRIN2D(3), GRM1(5), GRM5(5), HRH2(1), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), OXTR(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(1), PDE1C(2), PDGFRA(8), PDGFRB(1), PHKA1(5), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PLN(1), PPID(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(1), PRKCA(3), PRKCG(5), PTGER3(1), PTGFR(1), RYR1(12), RYR2(16), RYR3(2), SLC25A5(2), SLC8A1(2), SLC8A2(2), SLC8A3(4), SPHK1(1), TACR3(7), TRHR(2), TRPC1(2)	41573159	346	98	387	118	126	96	9	82	31	2	0.293	1.000	1.000
442	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(14), CACNA1A(1), CRHR1(2), GNA12(1), GNAI1(2), GNAQ(1), GNAS(4), GNAZ(2), GRIA1(3), GRIA2(6), GRIA3(4), GRID2(3), GRM1(5), GRM5(5), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IGF1R(5), ITPR1(2), ITPR2(8), ITPR3(5), KRAS(63), MAP2K1(2), MAP2K2(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(2), NPR2(2), NRAS(11), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP2CB(2), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(3), PRKCG(5), PRKG1(6), PRKG2(2), RAF1(3), RYR1(12)	17997623	238	97	195	59	53	109	6	54	15	1	0.0192	1.000	1.000
443	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	191	ACTN1(4), ACTN2(4), ACTN4(1), AKT2(1), AKT3(1), ARHGAP5(8), BCAR1(1), BIRC2(2), BIRC3(7), BRAF(14), CAPN2(2), CAV1(1), CAV3(1), CDC42(1), CHAD(1), COL11A1(9), COL11A2(2), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), CTNNB1(21), DOCK1(2), EGF(1), EGFR(11), ERBB2(9), FARP2(1), FIGF(2), FLNA(7), FLNB(4), FLNC(3), FLT1(9), FN1(6), FYN(2), GRB2(2), GRLF1(1), GSK3B(1), HGF(4), IGF1R(5), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAV(4), ITGB1(1), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), KDR(4), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), MAP2K1(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK9(3), MET(7), MYL9(3), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDGFB(1), PDGFC(1), PDGFD(1), PDGFRA(8), PDGFRB(1), PGF(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(5), PTEN(47), RAF1(3), RAP1A(1), RELN(12), RHOA(1), ROCK1(8), ROCK2(5), SHC1(1), SOS1(5), SOS2(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TLN1(2), TLN2(4), TNC(3), TNN(3), TNR(3), VAV1(2), VAV2(2), VAV3(3), VCL(1), VEGFC(4), VTN(3), VWF(6), ZYX(3)	59405753	587	96	574	223	148	171	10	199	57	2	0.946	1.000	1.000
444	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	223	ADCYAP1R1(1), ADORA1(4), ADORA2A(3), ADORA3(1), ADRA1A(2), ADRA1B(1), ADRA2B(1), ADRB1(2), ADRB3(2), AGTR1(2), AGTR2(2), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(2), CCKAR(3), CCKBR(4), CGA(1), CHRM2(4), CHRM3(2), CHRM5(1), CNR1(3), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR2(2), DRD2(2), DRD3(1), DRD5(4), EDNRA(1), EDNRB(6), F2(1), F2RL1(1), F2RL2(2), FPR1(3), FSHB(2), FSHR(3), GABBR1(4), GABBR2(8), GABRA1(4), GABRA2(3), GABRA3(1), GABRA4(3), GABRA5(3), GABRA6(2), GABRB1(1), GABRB2(3), GABRB3(5), GABRE(2), GABRG1(4), GABRG2(5), GABRG3(1), GABRP(4), GABRQ(3), GALR1(1), GH1(1), GH2(2), GLP1R(5), GLP2R(2), GLRA2(1), GLRA3(1), GLRB(1), GPR156(2), GPR63(3), GPR83(1), GRIA1(3), GRIA2(6), GRIA3(4), GRIA4(10), GRID1(2), GRID2(3), GRIK2(6), GRIK3(5), GRIK4(1), GRIK5(1), GRIN2A(7), GRIN2B(3), GRIN2C(2), GRIN2D(3), GRIN3A(3), GRM1(5), GRM2(3), GRM3(4), GRM5(5), GRM6(3), GRM7(6), GRM8(2), GZMA(3), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), LEPR(6), LTB4R(1), MAS1(1), MC2R(3), MC3R(1), MC4R(1), MC5R(2), MCHR2(2), MLNR(1), MTNR1A(1), MTNR1B(4), NMBR(1), NMUR2(3), NPBWR1(2), NPFFR2(1), NPY5R(2), NR3C1(3), NTSR2(1), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), P2RY1(3), P2RY10(3), P2RY14(2), P2RY2(2), P2RY6(1), PARD3(2), PPYR1(3), PRL(1), PRLR(2), PRSS1(1), PTGDR(2), PTGER3(1), PTGFR(1), PTH2R(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(1), SSTR2(2), SSTR4(2), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(3), TAAR8(1), TACR3(7), TRHR(2), TRPV1(2), TSHB(1), TSHR(4), VIPR1(1)	35342127	383	91	380	134	143	119	7	81	32	1	0.181	1.000	1.000
445	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(4), ACTN2(4), ACTN4(1), ARHGAP5(8), BCAR1(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CTNNA1(2), CTNNA2(5), CTNNB1(21), CXCR4(1), CYBB(2), GNAI1(2), GRLF1(1), ITGA4(6), ITGAL(3), ITGAM(1), ITGB1(1), ITGB2(2), ITK(5), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(6), MMP9(5), MSN(3), MYL9(3), NCF2(2), NCF4(1), NOX3(3), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PLCG1(2), PLCG2(5), PRKCA(3), PRKCG(5), PTPN11(10), RAP1A(1), RAPGEF3(2), RHOA(1), RHOH(1), ROCK1(8), ROCK2(5), SIPA1(1), TXK(2), VAV1(2), VAV2(2), VAV3(3), VCAM1(3), VCL(1)	19986595	242	85	233	77	56	71	1	94	18	2	0.630	1.000	1.000
446	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), ATP1A4(3), ATP1B2(2), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(4), CACNA1A(1), CACNA1B(4), CACNA1C(3), CACNA1D(1), CACNA1E(3), CACNA1S(5), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(4), CHRM3(2), CHRM5(1), GJA1(4), GJB3(1), GJB4(1), GNAQ(1), GNAZ(2), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNB1(3), KCNJ5(1), MIB1(5), MYCBP(1), NME7(3), PKIA(2), PLCB3(1), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RGS17(1), RGS2(2), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(2), RGS9(3), RYR1(12), RYR2(16), RYR3(2), SLC8A1(2), SLC8A3(4), USP5(1), YWHAH(2)	29231321	214	80	258	75	78	68	1	38	28	1	0.371	1.000	1.000
447	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN1(4), ACTN2(4), ACTN4(1), ACVR1B(3), ACVR1C(2), BAIAP2(1), CDC42(1), CDH1(12), CREBBP(13), CTNNA1(2), CTNNA2(5), CTNNB1(21), EGFR(11), EP300(14), ERBB2(9), FARP2(1), FER(3), FGFR1(2), FYN(2), IGF1R(5), INSR(1), IQGAP1(7), LMO7(2), MAP3K7(2), MAPK3(1), MET(7), MLLT4(4), PARD3(2), PTPN1(1), PTPRB(2), PTPRF(2), PTPRJ(3), PTPRM(10), PVRL1(2), PVRL2(1), PVRL3(1), PVRL4(1), RHOA(1), SMAD2(7), SMAD3(5), SMAD4(25), SNAI1(1), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L1(1), TCF7L2(13), TGFBR1(3), TGFBR2(2), TJP1(4), VCL(1), WASF1(3), WASF3(3), WASL(2), YES1(1)	19960771	246	79	234	65	58	71	2	80	34	1	0.143	1.000	1.000
448	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	134	CHAD(1), COL11A1(9), COL11A2(2), COL17A1(3), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), DES(1), DSC1(2), DSC2(1), DSC3(1), DSG1(4), DSG2(1), DSG4(5), FN1(6), GJA1(4), GJA10(5), GJA3(1), GJA8(3), GJA9(1), GJB3(1), GJB4(1), GJB7(1), GJC1(1), GJC3(1), GJD2(1), INA(1), ITGA6(2), ITGB4(2), KRT1(1), KRT12(1), KRT14(2), KRT15(1), KRT17(1), KRT2(1), KRT20(1), KRT24(3), KRT27(1), KRT3(3), KRT32(1), KRT33B(1), KRT35(2), KRT37(3), KRT38(2), KRT4(8), KRT5(1), KRT6A(1), KRT6C(1), KRT7(2), KRT73(4), KRT74(2), KRT75(1), KRT78(1), KRT79(1), KRT81(1), KRT82(2), KRT83(1), KRT84(4), KRT85(3), KRT9(1), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), LMNA(1), LMNB1(2), LMNB2(1), NES(2), PRPH(1), RELN(12), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNC(3), TNN(3), TNR(3), VIM(2), VTN(3), VWF(6)	39636747	275	78	273	132	107	85	3	43	37	0	0.998	1.000	1.000
449	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDS1(2), CDS2(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), IMPA2(1), INPP1(1), INPP4B(3), INPP5D(2), INPPL1(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), OCRL(5), PI4KA(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3C3(4), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PIP5K1B(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PRKCA(3), PRKCG(5), PTEN(47), PTPMT1(2), SYNJ1(4), SYNJ2(1)	19949920	236	77	233	78	47	67	4	96	19	3	0.820	1.000	1.000
450	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(2), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ATF1(1), ATF2(1), ATF4(2), ATP2A2(1), ATP2A3(2), CACNB3(1), CAMK2D(1), CNN1(1), CNN2(1), CORIN(3), CREB3(1), CRHR1(2), DGKZ(1), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GJA1(4), GNAQ(1), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), GSTO1(1), GUCY1A3(8), IGFBP3(2), IL1B(1), IL6(2), ITPR1(2), ITPR2(8), ITPR3(5), MIB1(5), MYL4(1), MYLK2(1), NFKB1(3), NOS1(8), NOS3(2), OXTR(1), PDE4B(4), PDE4D(2), PKIA(2), PLCB3(1), PLCD1(1), PLCG1(2), PLCG2(5), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), RAMP3(1), RGS17(1), RGS2(2), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(2), RGS9(3), RLN1(1), RYR1(12), RYR2(16), RYR3(2), SLC8A1(2), SP1(1), USP5(1), YWHAH(2)	26207793	205	77	232	62	71	71	2	32	28	1	0.115	1.000	1.000
451	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(3), ACVR1B(3), ACVRL1(1), BMPR2(3), BUB1(3), CDKL1(3), CDS1(2), CDS2(1), CLK1(2), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), MAP3K10(1), MOS(2), NEK3(1), OCRL(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3CA(56), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG1(2), PLCG2(5), PRKACA(1), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), PRKCZ(1), PRKD1(6), PRKG1(6), RAF1(3), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), TGFBR1(3), VRK1(1)	18404608	193	76	185	60	41	53	1	78	20	0	0.707	1.000	1.000
452	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(1), CADM1(3), CADM3(2), CD22(2), CD226(2), CD274(1), CD28(1), CD40(1), CD58(1), CD6(1), CD80(2), CD8A(1), CDH1(12), CDH15(1), CDH2(7), CDH3(2), CDH4(5), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(1), CLDN6(1), CLDN8(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(6), CTLA4(1), GLG1(2), HLA-A(3), HLA-B(3), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(8), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), HLA-F(1), HLA-G(1), ICAM2(1), ICOSLG(1), ITGA4(6), ITGA6(2), ITGA8(4), ITGA9(4), ITGAL(3), ITGAM(1), ITGAV(4), ITGB1(1), ITGB2(2), ITGB7(3), ITGB8(3), L1CAM(3), MAG(2), NCAM1(2), NCAM2(8), NEO1(2), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(4), NRXN1(5), NRXN2(3), NRXN3(2), PTPRC(9), PTPRF(2), PTPRM(10), PVR(1), PVRL1(2), PVRL2(1), PVRL3(1), SDC1(2), SDC2(1), SDC3(2), SELE(2), SELP(2), SELPLG(3), SIGLEC1(2), SPN(2), VCAM1(3), VCAN(14)	23640540	230	74	228	73	66	72	4	45	39	4	0.398	1.000	1.000
453	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ABL1(4), ACTN1(4), ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(3), ARHGEF7(2), BCAR1(1), BRAF(14), CAV1(1), CDC42(1), CDKN2A(2), DOCK1(2), EPHB2(1), FYN(2), GRB2(2), GRLF1(1), ITGA10(4), ITGA2(1), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGB3BP(2), MAP2K4(4), MAP2K7(2), MAP3K11(1), MAPK10(4), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PIK3CA(56), PIK3CB(1), PKLR(1), PLCG1(2), PLCG2(5), PTEN(47), RAF1(3), RALA(1), RHO(1), ROCK1(8), ROCK2(5), SHC1(1), SOS1(5), SOS2(2), TERF2IP(1), TLN1(2), TLN2(4), ZYX(3)	19965070	258	73	251	100	45	75	6	106	26	0	0.983	1.000	1.000
454	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	154	ADORA1(4), ADORA2A(3), ADORA3(1), ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), AGTR1(2), AGTR2(2), AVPR1A(2), BDKRB1(1), BDKRB2(2), BRS3(2), C3AR1(2), CCBP2(5), CCKAR(3), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CCR9(2), CCRL1(3), CHML(4), CHRM2(4), CHRM3(2), CHRM5(1), CMKLR1(3), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD2(2), DRD3(1), DRD5(4), EDNRA(1), EDNRB(6), F2RL1(1), F2RL2(2), FPR1(3), FSHR(3), GALR1(1), GPR17(1), GPR174(2), GPR37(3), GPR4(1), GPR6(1), GPR63(3), GPR77(1), GPR83(1), GPR85(1), GPR87(1), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1), LTB4R(1), MAS1(1), MC3R(1), MC4R(1), MC5R(2), MLNR(1), MTNR1A(1), MTNR1B(4), NMBR(1), NMUR2(3), NPY5R(2), NTSR2(1), OPN3(1), OPRK1(2), OPRL1(1), OPRM1(3), OR12D3(3), OR1C1(2), OR1Q1(1), OR2H1(2), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(1), OXTR(1), P2RY1(3), P2RY10(3), P2RY12(1), P2RY14(2), P2RY2(2), P2RY6(1), PPYR1(3), PTGDR(2), PTGFR(1), RGR(1), RHO(1), RRH(2), SSTR1(1), SSTR2(2), SSTR4(2), SUCNR1(3), TRHR(2)	18913775	208	72	208	63	75	75	3	43	12	0	0.0161	1.000	1.000
455	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT2(1), AKT3(1), CBL(7), CBLB(3), CREBBP(13), CSF3(1), CSF3R(1), EP300(14), GH1(1), GH2(2), GRB2(2), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), IFNK(2), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(5), IL13RA1(1), IL13RA2(2), IL19(1), IL2(1), IL20(1), IL20RA(2), IL21R(3), IL23R(1), IL28A(1), IL2RA(3), IL2RB(1), IL2RG(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL9(1), JAK1(2), JAK2(7), JAK3(4), LEPR(6), LIFR(6), MPL(4), OSMR(2), PIAS2(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PIM1(1), PRL(1), PRLR(2), PTPN11(10), SOCS2(2), SOCS4(1), SOCS5(2), SOS1(5), SOS2(2), SPRED1(1), SPRED2(1), SPRY1(1), STAM(1), STAT1(2), STAT2(2), STAT4(3), STAT5A(2), STAT5B(1), TPO(7)	23975102	248	72	237	88	43	74	5	92	30	4	0.930	1.000	1.000
456	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	CD44(1), CHAD(1), COL11A1(9), COL11A2(2), COL1A2(2), COL2A1(1), COL3A1(6), COL4A1(2), COL4A2(2), COL4A4(3), COL4A6(1), COL5A1(4), COL5A2(3), COL5A3(6), COL6A1(1), COL6A2(3), COL6A3(18), COL6A6(4), DAG1(2), FN1(6), FNDC1(7), FNDC3A(2), GP5(1), GP6(2), HMMR(2), HSPG2(1), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAV(4), ITGB1(1), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), LAMA1(7), LAMA2(4), LAMA3(6), LAMA4(4), LAMA5(3), LAMB2(3), LAMB3(2), LAMB4(7), LAMC1(5), LAMC2(3), LAMC3(2), RELN(12), SDC1(2), SDC2(1), SDC3(2), SV2A(2), SV2B(2), THBS1(2), THBS2(9), THBS3(2), THBS4(2), TNC(3), TNN(3), TNR(3), VTN(3), VWF(6)	35452440	239	71	250	107	83	73	6	46	31	0	0.974	1.000	1.000
457	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT2(1), AKT3(1), CASP8(1), CD40(1), CD80(2), CHUK(4), CXCL10(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL1B(1), IL6(2), IL8(1), IRAK4(2), IRF3(2), LBP(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), RELA(1), STAT1(2), TBK1(1), TLR1(3), TLR2(5), TLR3(2), TLR4(3), TLR5(2), TLR6(2), TLR7(3), TLR8(9), TLR9(4), TNF(1), TRAF3(2)	14660027	187	70	178	53	38	55	4	70	17	3	0.331	1.000	1.000
458	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	240	ACVR1(3), ACVR1B(3), ACVR2A(2), ACVR2B(2), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(3), CCL11(1), CCL18(1), CCL22(1), CCR1(1), CCR3(2), CCR4(1), CCR7(2), CCR9(2), CD40(1), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(1), CXCL14(1), CXCL16(1), CXCL5(1), CXCL9(1), CXCR3(1), CXCR4(1), EDA(3), EDAR(2), EGF(1), EGFR(11), FAS(2), FLT1(9), FLT3(9), FLT4(2), GDF5(2), GH1(1), GH2(2), HGF(4), IFNA1(1), IFNA10(2), IFNA2(1), IFNA4(1), IFNAR2(1), IFNGR1(2), IFNGR2(1), IFNK(2), IL10(1), IL10RA(1), IL10RB(1), IL12A(1), IL12RB2(5), IL13RA1(1), IL17A(1), IL17RA(1), IL18R1(3), IL18RAP(2), IL19(1), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(1), IL20(1), IL20RA(2), IL21R(3), IL23R(1), IL28A(1), IL2RA(3), IL2RB(1), IL2RG(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(1), IL8(1), IL9(1), INHBA(4), INHBC(1), INHBE(1), KDR(4), KIT(22), LEPR(6), LIFR(6), LTBR(1), MET(7), MPL(4), NGFR(1), OSMR(2), PDGFB(1), PDGFC(1), PDGFRA(8), PDGFRB(1), PRL(1), PRLR(2), TGFB2(4), TGFBR1(3), TGFBR2(2), TNF(1), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF11B(2), TNFRSF13B(1), TNFRSF21(1), TNFRSF8(1), TNFRSF9(1), TNFSF10(1), TNFSF13B(1), TNFSF14(1), TNFSF4(2), TNFSF8(2), TPO(7), VEGFC(4), XCL2(1), XCR1(1)	29424144	266	69	261	86	56	84	4	84	37	1	0.557	1.000	1.000
459	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTN2(4), ACTN4(1), DES(1), DMD(13), FAM48A(4), MYBPC1(3), MYBPC3(1), MYH3(7), MYH6(7), MYH7(4), MYH8(5), MYL1(1), MYL4(1), MYL9(3), MYOM1(8), NEB(8), TMOD1(1), TNNI3(1), TPM2(1), TPM3(1), TPM4(1), TTN(155), VIM(2)	17925243	235	69	246	59	62	93	1	63	15	1	0.0784	1.000	1.000
460	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT2(1), AKT3(1), CDC42(1), CDKN1B(2), CDKN2A(2), CREB3(1), CREB5(3), EBP(1), ERBB4(9), F2RL2(2), GRB2(2), GSK3B(1), IFI27(4), INPPL1(2), IRS1(4), IRS4(6), MET(7), NOLC1(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(56), PIK3CD(1), PPP1R13B(1), PREX1(5), PTEN(47), PTPN1(1), RPS6KA2(3), RPS6KA3(3), SHC1(1), SLC2A4(1), SOS1(5), SOS2(2), TSC1(1), TSC2(2), YWHAH(2)	12425943	198	66	186	74	28	60	2	87	21	0	0.961	1.000	1.000
461	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(1), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADCY9(3), ADSS(3), AK1(1), AK5(3), AK7(1), ALLC(2), AMPD1(3), AMPD2(1), AMPD3(1), ATIC(1), CANT1(1), DCK(1), ENPP3(2), ENTPD1(1), ENTPD4(1), ENTPD5(1), ENTPD6(1), GDA(1), GMPR(1), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(4), NME6(1), NME7(3), NPR1(2), NPR2(2), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1), PAPSS1(1), PAPSS2(2), PDE10A(7), PDE11A(3), PDE1A(2), PDE1C(2), PDE3B(2), PDE4B(4), PDE4D(2), PDE5A(4), PDE7A(1), PDE7B(2), PDE8B(3), PDE9A(1), PFAS(1), PKLR(1), PNPT1(5), POLA1(5), POLA2(1), POLD1(2), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLR3A(4), POLR3B(6), POLR3K(1), PPAT(3), PRIM2(1), PRPS1(1), PRPS1L1(1), PRUNE(1), RFC5(2), RRM1(1)	27551646	183	65	185	48	60	67	2	29	25	0	0.0586	1.000	1.000
462	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(2), DOCK1(2), FOS(1), GRB2(2), HGF(4), ITGB1(1), MAP2K1(2), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(6), MET(7), PAK1(1), PIK3CA(56), PIK3R1(9), PTEN(47), PTPN11(10), RAF1(3), RAP1A(1), RASA1(4), SOS1(5)	7478938	166	63	158	56	16	46	3	88	11	2	0.880	1.000	1.000
463	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(1), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF11(4), BTK(1), CDC42(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(5), LIMK1(1), MYLK(4), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3CG(5), PIK3R1(9), PPP1R13B(1), PTEN(47), RHO(1), ROCK1(8), ROCK2(5), RPS4X(2), WASF1(3), WASL(2)	11359638	188	63	185	58	32	50	1	79	23	3	0.717	1.000	1.000
464	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	ATF1(1), BRAF(14), CREB3(1), CREB5(3), CREBBP(13), DAG1(2), EGR1(3), EGR2(2), FRS2(2), GNAQ(1), MAP1B(13), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), NTRK1(1), OPN1LW(1), PIK3C2G(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PTPN11(10), RPS6KA3(3), SHC1(1), TERF2IP(1)	7928297	162	63	149	51	27	43	6	68	16	2	0.536	1.000	1.000
465	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	CPT1B(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(14), MAPK3(1), ME1(3), NCOA1(2), NCOR1(5), NCOR2(6), NR2F1(1), NRIP1(1), PIK3CA(56), PIK3R1(9), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), PRKCA(3), PTGS2(1), RB1(16), RELA(1), SP1(1), SRA1(1), STAT5A(2), STAT5B(1), TNF(1)	10401284	152	62	137	45	33	26	3	68	20	2	0.510	1.000	1.000
466	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT2(1), AKT3(1), BRD4(1), CAP1(1), CBL(7), CDC42(1), CDKN2A(2), F2RL2(2), FLOT1(1), GRB2(2), GSK3B(1), INPPL1(2), IRS1(4), IRS4(6), LNPEP(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(56), PIK3CD(1), PIK3R1(9), PPYR1(3), PTEN(47), PTPN1(1), RAF1(3), RPS6KA2(3), RPS6KA3(3), SERPINB6(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(5), SOS2(2), YWHAH(2)	9592622	183	62	173	62	30	47	1	88	15	2	0.833	1.000	1.000
467	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), AKT3(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), ITPR1(2), ITPR2(8), ITPR3(5), PDK1(2), PIK3CA(56), PLCG2(5), PPP1R13B(1), PREX1(5), PTEN(47), PTPRC(9), RPS6KA2(3), RPS6KA3(3), SYK(3), TEC(2), VAV1(2)	8962103	160	60	157	57	22	49	1	74	13	1	0.929	1.000	1.000
468	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA2(1), INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), MINPP1(2), OCRL(5), PI4KA(5), PIK3C3(4), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIP5K1B(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(2), PLCG1(2), PLCG2(5), PLCZ1(3), PTEN(47), PTPMT1(2), SYNJ1(4), SYNJ2(1)	11988992	163	59	152	61	17	50	4	81	11	0	0.976	1.000	1.000
469	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), FOS(1), GRB2(2), MAP2K1(2), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAPK3(1), MAPK8(6), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), PAK2(1), PIK3CA(56), PIK3R1(9), PLA2G4A(3), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(3), SHC1(1), SOS1(5), SYK(3), VAV1(2)	7152162	120	58	111	33	23	29	2	53	11	2	0.369	1.000	1.000
470	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B2(1), EIF2B5(1), EIF2S3(1), FLT1(9), FLT4(2), HIF1A(2), KDR(4), NOS3(2), PIK3CA(56), PIK3R1(9), PLCG1(2), PRKCA(3), SHC1(1), VHL(22)	5533853	116	58	105	32	17	23	2	66	6	2	0.442	1.000	1.000
471	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(2), EIF4G1(2), EIF4G3(3), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PDK2(1), PIK3CA(56), PIK3R1(9), PRKCA(3), PTEN(47)	4742134	131	57	121	48	13	34	2	71	9	2	0.945	1.000	1.000
472	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(1), EIF2S3(1), GSK3B(1), IGF1R(5), INPPL1(2), PDK2(1), PIK3CA(56), PIK3R1(9), PTEN(47), RPS6(1)	3343747	124	57	114	44	7	35	1	71	8	2	0.946	1.000	1.000
473	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(1), AKT3(1), BTK(1), CDKN2A(2), GRB2(2), GSK3B(1), IARS(1), INPP5D(2), PDK1(2), PIK3CA(56), PPP1R13B(1), PTEN(47), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(5), SOS2(2), TEC(2), YWHAH(2)	5980212	135	57	125	52	12	40	1	75	7	0	0.971	1.000	1.000
474	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP1(1), INPP4B(3), INPPL1(2), ITPKB(1), OCRL(5), PIK3C2A(8), PIK3C2B(7), PIK3C2G(2), PIK3CA(56), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG1(2), PLCG2(5)	7276040	105	56	96	30	14	28	1	54	8	0	0.659	1.000	1.000
475	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(2), EIF4B(1), EIF4G1(2), EIF4G3(3), FKBP1A(1), MKNK1(2), PDK2(1), PIK3CA(56), PIK3R1(9), PTEN(47), RPS6(1), TSC1(1), TSC2(2)	4552652	128	56	118	46	12	35	2	69	8	2	0.926	1.000	1.000
476	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), CDKN1B(2), GRB2(2), ITGB1(1), MAPK3(1), PDK2(1), PIK3CA(56), PIK3R1(9), PTEN(47), SHC1(1), SOS1(5)	3178714	126	56	116	43	7	35	1	71	10	2	0.915	1.000	1.000
477	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT2(1), AKT3(1), BRAF(14), EIF4B(1), FIGF(2), HIF1A(2), MAPK3(1), PGF(1), PIK3CA(56), PIK3CB(1), PIK3CD(1), PIK3CG(5), PIK3R1(9), PIK3R3(4), PRKAA1(1), PRKAA2(5), RHEB(1), RICTOR(3), RPS6(1), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB2(2), TSC1(1), TSC2(2), ULK1(2), VEGFC(4)	8399760	130	55	118	39	22	30	2	62	12	2	0.601	1.000	1.000
478	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(5), BAX(2), IGF1R(5), KIT(22), PIK3CA(56), PIK3R1(9), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), YWHAH(2)	3537259	111	54	101	36	16	23	1	61	8	2	0.778	1.000	1.000
479	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK14(1), MAPK3(1), NFKB1(3), PIK3CA(56), PIK3R1(9), RB1(16), RELA(1), SP1(1)	3376975	98	54	88	33	13	19	2	54	8	2	0.804	1.000	1.000
480	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), AKT3(1), GRB2(2), MAPK3(1), PDK1(2), PIK3CA(56), PIK3CD(1), PTEN(47), RBL2(2), SHC1(1), SOS1(5)	3391843	119	54	109	44	7	35	1	70	6	0	0.963	1.000	1.000
481	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(1), GORASP1(2), MAP2K4(4), MAP2K7(2), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), MAPK8IP1(1), MAPK8IP3(1), MAPK9(3), MAPKAPK5(1), NFKB1(3), NFKB2(2), NFKBIE(1), PIK3CA(56), PIK3CD(1), PIK3R1(9), TRAF3(2), TRAF5(2)	4832772	105	54	96	31	18	24	2	48	11	2	0.547	1.000	1.000
482	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	CABIN1(2), CAMK1(2), CAMK1G(2), HDAC5(1), IGF1R(5), INSR(1), MAP2K6(1), MAPK14(1), MEF2A(2), NFATC1(2), NFATC2(2), PIK3CA(56), PIK3R1(9), PPP3CA(2), PPP3CB(1), PPP3CC(2), YWHAH(2)	5371698	93	53	85	31	13	23	1	46	8	2	0.767	1.000	1.000
483	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT3(1), BCAR1(1), CAPN2(2), CAPN3(1), CAPN5(3), CAPN6(2), CAPN7(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(2), GIT2(1), GRB2(2), ITGA10(4), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGA8(4), ITGA9(4), ITGAD(1), ITGAE(2), ITGAL(3), ITGAM(1), ITGAV(4), ITGAX(2), ITGB1(1), ITGB2(2), ITGB3(4), ITGB4(2), ITGB5(1), ITGB6(3), ITGB7(3), ITGB8(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK6(1), MYLK2(1), PAK1(1), PAK2(1), PAK3(3), RHO(1), ROCK1(8), ROCK2(5), SDCCAG8(2), SEPP1(1), SHC1(1), SORBS1(4), SOS1(5), TLN1(2), TNS1(5), VAV2(2), VAV3(3), VCL(1), ZYX(3)	21777796	142	52	146	52	36	49	7	27	23	0	0.755	1.000	1.000
484	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(1), BRAF(14), CHUK(4), DAXX(4), FOS(1), GRB2(2), IKBKB(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(4), MAP2K5(2), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(4), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(3), MAP4K4(1), MAPK10(4), MAPK13(2), MAPK14(1), MAPK3(1), MAPK6(1), MAPK8(6), MAPK9(3), MAPKAPK2(1), MAPKAPK5(1), MEF2A(2), MKNK1(2), MKNK2(1), NFKB1(3), PAK1(1), PAK2(1), RAF1(3), RELA(1), RPS6KA2(3), RPS6KA3(3), RPS6KA4(1), RPS6KA5(3), RPS6KB2(2), SHC1(1), SP1(1), STAT1(2), TGFB2(4), TGFBR1(3)	15253500	130	52	130	38	23	36	4	49	18	0	0.416	1.000	1.000
485	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK4(1), CDKN1B(2), MAPK3(1), NFKB1(3), PAK1(1), PIK3CA(56), PIK3R1(9), RAF1(3), RB1(16), RELA(1)	3416602	93	52	83	32	15	15	1	51	9	2	0.832	1.000	1.000
486	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(13), ASH2L(1), CTCFL(1), DOT1L(1), EHMT1(2), EHMT2(3), EZH1(1), EZH2(2), FBXO11(1), HCFC1(2), HSF4(1), JMJD4(1), JMJD6(1), KDM6A(1), MEN1(6), MLL(8), MLL2(8), MLL3(13), MLL4(5), MLL5(6), NSD1(4), OGT(2), PAXIP1(5), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRDM9(10), PRMT7(1), PRMT8(3), SATB1(1), SETD1A(1), SETD2(8), SETD7(2), SETDB1(1), SETDB2(2), SETMAR(1), SMYD3(2), STK38(4), SUV39H2(1), SUV420H1(4), SUZ12(1), WHSC1(3)	19090018	138	51	136	34	37	38	1	37	24	1	0.254	1.000	1.000
487	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	103	A4GNT(2), ALG1(1), ALG10B(4), ALG11(1), ALG14(1), ALG8(1), ALG9(1), B3GNT2(1), B4GALT1(1), B4GALT3(2), B4GALT5(1), CHST1(1), CHST11(2), CHST12(2), CHST2(2), CHST3(1), CHST4(2), DPAGT1(2), EXT1(2), EXT2(2), EXTL2(3), EXTL3(2), FUT11(1), FUT8(1), GALNT12(1), GALNT13(1), GALNT14(1), GALNT2(5), GALNT5(7), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GANAB(1), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(1), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), MAN1A1(2), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT4A(1), MGAT4B(1), MGAT5B(1), NDST1(1), NDST2(1), NDST3(4), OGT(2), RPN2(1), ST3GAL1(1), ST6GALNAC1(1), STT3B(2), UST(2), WBSCR17(5), XYLT1(2)	17682677	118	51	117	47	38	34	2	35	9	0	0.869	1.000	1.000
488	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(7), CD28(1), CD3D(1), CSK(2), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(1), FBXW7(37), GRAP2(4), GRB2(2), ITK(5), ITPKB(1), LAT(1), LCK(1), LCP2(1), NCK1(1), NFKB1(3), NFKB2(2), NFKBIE(1), PAK1(1), PAK2(1), PAK3(3), PAK7(7), PLCG1(2), PTPRC(9), RAF1(3), RASGRP1(1), RASGRP2(2), RASGRP3(1), SOS1(5), SOS2(2), VAV1(2)	8931815	114	51	115	32	34	32	1	32	14	1	0.360	1.000	1.000
489	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	CABIN1(2), CAMK4(3), CD3G(1), CD69(2), CNR1(3), CREBBP(13), CTLA4(1), EGR2(2), EP300(14), FCER1A(1), FCGR3A(1), FOS(1), GRLF1(1), GSK3B(1), IFNA1(1), IL10(1), IL1B(1), IL2(1), IL2RA(3), IL6(2), IL8(1), ITK(5), MAP2K7(2), MAPK14(1), MAPK8(6), MAPK9(3), MEF2A(2), MYF5(2), NCK2(1), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB2(2), NFKBIE(1), NPPB(1), NUP214(4), P2RX7(1), PAK1(1), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPRC(9), RELA(1), SP1(1), SP3(3), TNF(1), TRPV6(6), VAV1(2), VAV2(2), VAV3(3)	14442763	127	50	130	39	42	34	3	30	18	0	0.313	1.000	1.000
490	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(3), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD22(2), CD33(1), CD38(1), CD3D(1), CD3G(1), CD44(1), CD5(2), CD55(1), CD7(2), CD8A(1), CR1(1), CR2(2), CSF1(1), CSF1R(1), CSF3(1), CSF3R(1), DNTT(2), FLT3(9), GP5(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(2), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(3), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(6), ITGA5(1), ITGA6(2), ITGAM(1), ITGB3(4), KIT(22), MME(4), TFRC(2), THPO(1), TNF(1), TPO(7)	13368362	120	50	124	35	33	38	3	34	12	0	0.287	1.000	1.000
491	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM17(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(2), ATP6V1E2(1), ATP6V1G1(1), ATP6V1G2(1), ATP6V1G3(2), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(4), CSK(2), EGFR(11), GIT1(1), IGSF5(2), IKBKB(2), IL8(1), MAP2K4(4), MAPK10(4), MAPK13(2), MAPK14(1), MAPK8(6), MAPK9(3), MET(7), NFKB1(3), NFKB2(2), NOD1(1), PAK1(1), PLCG1(2), PLCG2(5), PTPN11(10), PTPRZ1(6), RELA(1), TCIRG1(1), TJP1(4)	11942493	111	50	111	33	25	33	2	41	9	1	0.441	1.000	1.000
492	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADA(1), ADCY1(5), ADCY2(7), ADCY3(1), ADCY5(3), ADCY7(3), ADCY8(4), ADSS(3), AK1(1), AK5(3), ALLC(2), AMPD1(3), AMPD2(1), AMPD3(1), ATIC(1), ATP5A1(3), ATP5C1(3), CANT1(1), DCK(1), ENPP3(2), ENTPD1(1), GDA(1), GUCY1A2(5), GUCY1A3(8), GUCY2C(1), GUCY2D(4), GUCY2F(4), IMPDH1(1), IMPDH2(4), NPR1(2), NPR2(2), NT5E(1), PAPSS1(1), PAPSS2(2), PDE1A(2), PDE4B(4), PDE4D(2), PDE5A(4), PDE6C(2), PDE7B(2), PDE9A(1), PFAS(1), PKLR(1), POLB(2), POLD1(2), POLE(4), POLG(1), POLL(2), POLQ(5), POLR1B(3), POLR2A(2), POLR2B(3), POLR2K(1), POLRMT(1), PPAT(3), PRPS1(1), PRPS1L1(1), PRUNE(1), RRM1(1)	21182558	138	50	139	42	45	45	2	27	19	0	0.338	1.000	1.000
493	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC4(4), ANAPC5(1), BTRC(4), CDC16(1), CDC27(5), CUL1(1), CUL2(1), FBXW11(1), FBXW7(37), FZR1(1), RBX1(1), SMURF1(2), SMURF2(1), TCEB1(1), UBA1(2), UBE2C(1), UBE2D3(1), UBE2E2(1), VHL(22), WWP1(3), WWP2(1)	7007949	93	49	88	34	20	23	1	33	15	1	0.888	1.000	1.000
494	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(1), CD3G(1), CD80(2), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), IL2(1), ITK(5), LCK(1), PIK3CA(56), PIK3R1(9), PTPN11(10)	2160321	92	48	84	27	12	23	1	48	6	2	0.694	1.000	1.000
495	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	CAT(1), GH1(1), IGF1R(5), PIK3CA(56), PIK3R1(9), SHC1(1)	2200607	73	47	64	25	6	16	1	45	3	2	0.846	1.000	1.000
496	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(56), PIK3R1(9), PLCB1(1), PLCG1(2), PRKCA(3), VAV1(2)	2250716	73	47	64	22	8	18	1	41	3	2	0.754	1.000	1.000
497	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(5), ABCA10(5), ABCA12(16), ABCA13(2), ABCA2(1), ABCA3(2), ABCA4(4), ABCA5(3), ABCA6(7), ABCA7(1), ABCA8(9), ABCA9(7), ABCB1(6), ABCB10(1), ABCB4(5), ABCB5(5), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(2), ABCC1(5), ABCC10(2), ABCC11(3), ABCC12(5), ABCC2(5), ABCC3(1), ABCC5(2), ABCC6(4), ABCC8(4), ABCC9(4), ABCD2(3), ABCG1(1), ABCG2(5), CFTR(5), TAP1(2), TAP2(1)	18979757	137	44	154	45	34	51	3	29	19	1	0.376	1.000	1.000
498	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(3), BDKRB1(1), BDKRB2(2), C1S(3), C2(4), C3(2), C3AR1(2), C4B(2), C4BPA(6), C5(5), C5AR1(1), C6(3), C7(1), C8A(3), C8B(1), C9(1), CD46(1), CD55(1), CFB(2), CFH(7), CPB2(1), CR1(1), CR2(2), F13A1(3), F13B(2), F2(1), F3(1), F5(7), F7(1), F8(7), F9(1), FGA(4), FGB(2), KLKB1(3), KNG1(1), MASP1(4), PLAT(1), PLAU(1), PLAUR(2), PLG(4), PROS1(3), SERPINA1(3), SERPINA5(1), SERPIND1(1), SERPINE1(2), SERPING1(2), TFPI(3), VWF(6)	15592644	121	44	128	32	32	46	2	30	11	0	0.145	1.000	1.000
499	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(4), AMY1B(1), AMY2A(2), AMY2B(3), ASCC3(5), DDX18(1), DDX19A(1), DDX23(4), DDX4(3), DDX50(1), DDX52(1), DDX55(1), DDX56(2), DHX58(2), ENPP3(2), EP400(4), ERCC3(1), G6PC(1), G6PC2(1), GANC(1), GCK(3), GPI(1), GYS1(1), GYS2(4), HK2(1), HK3(5), IFIH1(2), MOV10L1(7), PGM1(2), PGM3(2), PYGL(2), PYGM(2), RAD54B(2), RUVBL2(2), SETX(10), SI(4), SKIV2L2(2), SMARCA2(3), SMARCA5(5), UGDH(1), UGP2(2), UGT1A4(2), UGT1A5(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(4), UGT2B11(2), UGT2B17(3), UGT2B28(2), UGT2B4(1), UGT2B7(2), UXS1(1)	20952945	125	43	124	35	31	38	1	31	24	0	0.327	1.000	1.000
500	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	53	BMP2(1), BMP4(1), BMP5(1), BMP6(2), BMP7(1), BTRC(4), CSNK1A1L(1), CSNK1D(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(7), GSK3B(1), HHIP(1), LRP2(16), PRKACA(1), PRKACB(1), PRKACG(1), PTCH1(13), PTCH2(2), RAB23(1), SMO(2), STK36(4), WNT10A(1), WNT10B(1), WNT2(2), WNT2B(2), WNT3(2), WNT4(1), WNT8A(1), WNT9B(1)	9338760	84	43	84	34	23	29	0	20	12	0	0.835	1.000	1.000
501	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(1), CCKBR(4), CCR3(2), CELSR1(1), CELSR2(2), CELSR3(1), CHRM2(4), CHRM3(2), CXCR3(1), EDNRA(1), EMR2(4), EMR3(1), FSHR(3), GPR116(5), GPR133(1), GPR17(1), GPR18(2), GPR56(1), GPR61(3), GPR77(1), GPR84(3), GRM1(5), LGR6(1), LPHN2(4), LPHN3(4), OR2M4(2), PTGFR(1), SMO(2), SSTR2(2), TAAR5(2), TSHR(4)	9904822	71	41	75	34	23	19	3	21	5	0	0.945	1.000	1.000
502	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	APAF1(4), BIRC2(2), BIRC3(7), CASP3(1), CASP6(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(4), CRADD(1), DAXX(4), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK8(6), NFKB1(3), NUMA1(5), PAK2(1), PRKDC(5), PSEN1(1), RASA1(4), RB1(16), RELA(1), SPTAN1(5), TNF(1), TRAF1(2)	11009050	90	41	91	28	28	21	1	28	12	0	0.625	1.000	1.000
503	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	67	ACACB(3), ACSL3(1), ACSL5(1), ACSL6(1), ADIPOR2(1), AKT2(1), AKT3(1), CAMKK2(1), CHUK(4), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), G6PC(1), G6PC2(1), IKBKB(2), IRS1(4), IRS4(6), JAK1(2), JAK2(7), JAK3(4), LEPR(6), MAPK10(4), MAPK8(6), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIE(1), NPY(1), PCK1(3), PRKAA1(1), PRKAA2(5), PRKAB1(2), PRKAG1(1), PRKAG2(1), PRKAG3(2), PRKCQ(1), PTPN11(10), RELA(1), RXRB(1), RXRG(1), SLC2A1(2), SLC2A4(1), TNF(1)	13465728	107	40	107	37	26	35	2	31	11	2	0.684	1.000	1.000
504	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(4), DAXX(4), EGF(1), EGFR(11), ETS1(4), ETS2(1), FOS(1), HOXA7(1), IKBKB(2), MAP2K1(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP2K7(2), MAP3K1(3), MAP3K5(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(6), NFKB1(3), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(1), RAF1(3), RELA(1), SP1(1), TNF(1)	8145568	77	40	76	28	24	17	2	29	5	0	0.706	1.000	1.000
505	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(2), CREBBP(13), CTBP2(1), DLL1(4), DLL3(1), DLL4(2), DTX2(2), DTX3(1), DTX3L(1), DVL2(1), DVL3(2), EP300(14), JAG1(1), LFNG(1), MAML1(2), MAML2(1), NCOR2(6), NOTCH1(1), NOTCH2(6), NOTCH3(4), NOTCH4(5), PSEN1(1), PTCRA(1), RBPJ(5), SNW1(1)	9674111	79	39	75	30	21	20	3	17	18	0	0.818	1.000	1.000
506	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), AKT3(1), BRAF(14), DAG1(2), DRD2(2), EGFR(11), EPHB2(1), GRB2(2), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(5), KCNJ5(1), KCNJ9(1), PI3(1), PIK3CB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), RAF1(3), RGS20(1), SHC1(1), SOS1(5), SOS2(2), TERF2IP(1)	9550400	73	38	77	24	20	15	1	31	5	1	0.640	1.000	1.000
507	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(1), FBXW7(37), RB1(16)	1497171	54	37	48	23	13	7	1	20	12	1	0.938	1.000	1.000
508	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	62	ACHE(2), AGPAT1(1), AGPAT4(2), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKA(2), CHPT1(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), ESCO1(6), ESCO2(5), ETNK2(1), GNPAT(2), GPAM(1), GPD1L(1), GPD2(1), MYST3(6), MYST4(8), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(3), PTDSS1(3), SH3GLB1(1)	10799817	84	37	85	29	30	25	1	20	8	0	0.605	1.000	1.000
509	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(1), ADCY8(4), CACNA1A(1), CACNA1B(4), GNAS(4), GNG3(1), ITPR3(5), KCNB1(3), PDE1A(2), PLCB2(1), PRKACA(1), PRKACB(1), PRKACG(1), SCNN1B(1), SCNN1G(3), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(4), TAS2R14(1), TAS2R16(2), TAS2R3(1), TAS2R38(1), TAS2R4(1), TAS2R5(2), TAS2R50(1), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2)	8584233	55	34	66	30	20	10	2	15	8	0	0.989	1.000	1.000
510	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ACAT2(1), ACMSD(2), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), AOC3(1), AOX1(3), CAT(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2D6(1), CYP2E1(2), CYP2F1(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), KMO(3), KYNU(1), MAOA(2), MAOB(3), TDO2(3), TPH1(2), WARS(1), WARS2(1)	9329079	67	34	66	28	16	24	1	17	9	0	0.919	1.000	1.000
511	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AOC3(1), AOX1(3), CAT(1), CYP1A1(1), CYP1A2(1), CYP1B1(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), HSD17B10(1), INMT(1), KMO(3), KYNU(1), LNX1(5), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), NFX1(3), OGDH(1), OGDHL(4), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), TDO2(3), TPH1(2), TPH2(3), WARS(1), WARS2(1)	10203360	72	32	71	27	16	29	1	14	12	0	0.769	1.000	1.000
512	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP3(1), CASP6(1), CASP8(1), CFLAR(1), DAXX(4), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MAP2K4(4), MAP3K1(3), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(1), PRKDC(5), PTPN13(3), RB1(16), SPTAN1(5)	6424618	60	31	72	18	13	14	1	22	10	0	0.648	1.000	1.000
513	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(2), CAMK2D(1), CDK5(1), F2(1), FYN(2), GNAI1(2), GNGT1(1), GRB2(2), JAK2(7), MAP2K1(2), MAP2K2(1), MAPK14(1), MAPK3(1), MAPK8(6), MAPT(1), MYLK(4), PLCG1(2), PRKCA(3), RAF1(3), SHC1(1), SOS1(5), STAT1(2), STAT5A(2)	7164918	55	30	55	22	13	16	1	23	1	1	0.881	1.000	1.000
514	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), ALDH7A1(2), AOC3(1), ASPA(2), HAL(1), HARS2(2), HDC(6), MAOA(2), MAOB(3), METTL2B(1), METTL6(3), PRMT2(1), PRMT3(1), PRMT7(1), PRMT8(3), PRPS1(1), UROC1(3)	6522554	47	30	44	18	13	14	2	7	11	0	0.775	1.000	1.000
515	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AGK(1), AGPAT1(1), AGPAT4(2), AGPAT6(1), AKR1B1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CEL(1), DAK(1), DGAT2(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKI(4), DGKZ(1), GK2(3), GPAM(1), LCT(7), LIPC(1), LIPF(2), MGLL(1), PNLIP(4), PNLIPRP2(1)	9610237	64	30	66	28	20	19	2	15	8	0	0.878	1.000	1.000
516	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	FOS(1), GRB2(2), IL6(2), IL6R(1), IL6ST(1), JAK1(2), JAK2(7), JAK3(4), MAP2K1(2), MAPK3(1), PTPN11(10), RAF1(3), SHC1(1), SOS1(5)	4017938	42	30	42	15	7	10	0	20	3	2	0.847	1.000	1.000
517	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	CASP3(1), CASP8(1), CRADD(1), DFFA(2), LMNA(1), LMNB1(2), LMNB2(1), MADD(4), MAP2K4(4), MAP3K1(3), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(1), PRKDC(5), RB1(16), SPTAN1(5), TNF(1)	6147349	57	30	60	22	16	12	1	19	9	0	0.879	1.000	1.000
518	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(3), CREBBP(13), EP300(14), ERCC3(1), ESR1(1), GRIP1(3), GTF2A1(1), GTF2F1(2), HDAC5(1), HDAC6(2), NCOR2(6), NR0B1(1), NRIP1(1), POLR2A(2), SRA1(1)	7620193	52	29	48	19	11	15	3	14	9	0	0.767	1.000	1.000
519	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(2), AGPAT1(1), AGPAT4(2), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKA(2), CLC(1), CPT1B(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), GNPAT(2), GPD2(1), LGALS13(1), PAFAH2(1), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G4A(3), PLA2G6(2), PLCB2(1), PLCG1(2), PLCG2(5)	7982003	51	29	53	29	26	9	0	11	5	0	0.988	1.000	1.000
520	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), BHMT(2), CBS(1), CHDH(3), CHKA(2), CPT1B(1), CTH(1), DAO(4), DLD(1), DMGDH(3), GCAT(1), GLDC(3), MAOA(2), MAOB(3), PISD(3), PLCB2(1), PLCG1(2), PLCG2(5), PSPH(1), SARDH(2), SARS(1), SHMT1(1), TARS(3)	6968155	51	28	51	21	23	13	0	10	5	0	0.793	1.000	1.000
521	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(11), GNAS(4), GNGT1(1), GRB2(2), IGF1R(5), ITGB1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(1), PDGFRA(8), PTPRR(5), RAF1(3), RPS6KA5(3), SHC1(1), SOS1(5)	5569512	57	27	57	20	10	14	3	26	3	1	0.776	1.000	1.000
522	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK3(1), COL2A1(1), CPSF1(1), CPSF3(1), CPSF4(1), CSTF1(1), CSTF2T(3), CSTF3(2), DDIT3(1), DDX1(1), DDX20(1), DHX15(2), DHX16(2), DHX38(2), DHX8(2), DHX9(1), DICER1(2), LSM2(1), METTL3(1), NCBP1(4), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PPM1G(1), PRPF18(1), PRPF4(1), PRPF4B(6), PRPF8(2), PTBP2(1), RBM5(3), RNMT(1), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(1), SNRPA(1), SNRPB(1), SNRPD3(1), SRPK1(1), SRPK2(3), SRRM1(3), SUPT5H(1), U2AF1(1), U2AF2(2), XRN2(2)	17832165	74	27	75	21	23	25	1	15	10	0	0.582	1.000	1.000
523	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(2), AGTR2(2), EDNRA(1), EDNRB(6), EGF(1), EGFR(11), FOS(1), NFKB1(3), PLCG1(2), PRKCA(3), RELA(1)	3534464	37	26	36	16	14	9	0	12	2	0	0.855	1.000	1.000
524	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), AGPAT1(1), AGPAT4(2), AKR1B1(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), CEL(1), DGKB(1), DGKD(3), DGKE(2), DGKG(1), DGKH(5), DGKZ(1), LCT(7), LIPC(1), LIPF(2), PNLIP(4), PNLIPRP2(1)	7826478	49	26	51	24	15	12	2	13	7	0	0.932	1.000	1.000
525	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), BHMT(2), CBS(1), CHDH(3), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(3), GCAT(1), GLDC(3), MAOA(2), MAOB(3), PIPOX(1), PISD(3), PSAT1(1), PSPH(1), RDH11(1), RDH12(1), SARDH(2), SARS(1), SHMT1(1), TARS(3), TARS2(1)	7207978	47	25	47	19	21	15	0	7	4	0	0.738	1.000	1.000
526	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(6), ACACB(3), ACAT2(1), ACOT12(3), ACSS1(1), ACSS2(1), ACYP1(1), AKR1B1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), DLAT(3), DLD(1), GRHPR(1), LDHA(4), LDHAL6A(1), LDHAL6B(1), LDHB(3), ME1(3), ME3(1), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	7956504	57	25	57	20	14	20	2	15	6	0	0.608	1.000	1.000
527	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ACADS(1), ACAT2(1), ACSM1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), BDH1(1), DDHD1(12), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HMGCL(1), HMGCS2(1), HSD17B10(1), ILVBL(1), PDHA1(1), PDHA2(3), PLA1A(2), PRDX6(1), RDH11(1), RDH12(1)	6978773	49	25	39	21	13	12	2	6	16	0	0.958	1.000	1.000
528	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(4), BAX(2), BCL2A1(3), CASP3(1), CASP4(3), CASP6(1), CASP8(1), CASP9(1), CD40(1), CRADD(1), DAXX(4), DFFA(2), FAS(2), IKBKE(1), NFKB1(3), NGFR(1), NR3C1(3), NTRK1(1), PTPN13(3), TNF(1), TRAF1(2), TRAF3(2)	7052170	43	24	50	17	7	11	0	17	8	0	0.899	1.000	1.000
529	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(6), ACAT2(1), ACYP1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), DLAT(3), DLD(1), GRHPR(1), LDHA(4), LDHB(3), ME1(3), ME3(1), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	6186345	47	24	47	21	14	14	2	12	5	0	0.881	1.000	1.000
530	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(2), FPR1(3), GNA15(1), GNGT1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK14(1), MAPK3(1), NCF2(2), NFATC1(2), NFATC2(2), NFATC3(2), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(3), RELA(1)	6240943	46	23	47	16	17	13	1	9	6	0	0.595	1.000	1.000
531	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(1), FBP2(1), G6PC(1), GALK2(1), GANAB(1), GCK(3), HK2(1), HK3(5), LALBA(1), LCT(7), PFKM(3), PFKP(1), PGM1(2), PGM3(2)	5168450	33	23	33	13	16	9	0	7	1	0	0.632	1.000	1.000
532	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH3B1(7), ALDH3B2(1), AOC3(1), ASPA(2), HAL(1), HDC(6), MAOA(2), MAOB(3), PRPS1(1)	4183750	31	23	28	15	6	9	2	5	9	0	0.958	1.000	1.000
533	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA2(2), ACADM(3), ACADS(1), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), ALDH7A1(2), AOX1(3), DLD(1), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), IVD(1), MCCC1(2), MCEE(2), MUT(1), PCCA(6), PCCB(1)	7509822	43	23	42	15	12	14	1	7	9	0	0.716	1.000	1.000
534	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3B1(7), ALDH3B2(1), AOC3(1), EPX(1), GOT1(1), HPD(1), LPO(1), MAOA(2), MAOB(3), MPO(4), PRDX1(1), PRDX6(1), TAT(2), TPO(7)	3662048	35	23	32	13	8	11	2	3	11	0	0.780	1.000	1.000
535	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	32	ATF1(1), CDC42(1), CREB3(1), CREB5(3), DUSP1(1), DUSP10(1), EEF2K(1), IL1R1(1), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K10(1), MAP3K4(4), MAP3K5(2), MAP3K7(2), MAPK13(2), MAPK14(1), MAPKAPK2(1), MAPKAPK5(1), MKNK1(2), MKNK2(1), NFKB1(3)	5509015	38	23	38	15	10	14	2	8	4	0	0.779	1.000	1.000
536	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(2), ACADM(3), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), AOC3(1), DPYD(10), DPYS(2), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), UPB1(2)	4986301	34	22	33	18	7	9	2	9	7	0	0.961	1.000	1.000
537	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(2), DLAT(3), DLD(1), ENO2(1), ENO3(1), FBP2(1), G6PC(1), GCK(3), GOT1(1), GPI(1), HK2(1), HK3(5), LDHA(4), LDHAL6B(1), LDHB(3), PC(4), PCK1(3), PDHA1(1), PDHA2(3), PFKM(3), PFKP(1), PGK2(1), PKLR(1)	6980960	46	22	46	22	20	14	0	8	4	0	0.837	1.000	1.000
538	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(4), GPRC5B(1), GPRC5C(1), GRM1(5), GRM2(3), GRM3(4), GRM5(5), GRM7(6), GRM8(2)	3319060	33	22	33	15	12	11	1	6	3	0	0.715	1.000	1.000
539	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), B4GALT1(1), G6PC(1), G6PC2(1), GALK2(1), GANC(1), GCK(3), HK2(1), HK3(5), LALBA(1), LCT(7), PFKM(3), PFKP(1), PGM1(2), PGM3(2), RDH11(1), RDH12(1), UGP2(2)	6091803	37	22	37	13	16	12	0	8	1	0	0.492	1.000	1.000
540	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(2), ACADM(3), ACADS(1), ACAT2(1), ACOX3(2), ACSL3(1), ACSL5(1), ACSL6(1), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CPT1A(3), CPT1B(1), CPT1C(2), CPT2(1), CYP4A11(1), DCI(1), ECHS1(1), EHHADH(2), GCDH(2), HADHA(2), HADHB(1), HSD17B10(1)	8270032	48	22	46	21	10	16	2	11	9	0	0.891	1.000	1.000
541	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(1), ALOX12B(2), ALOX15(1), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2E1(2), CYP4A11(1), CYP4F3(1), GGT1(2), GPX1(1), GPX3(2), GPX5(1), GPX6(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(2)	6555387	37	22	37	13	16	5	2	6	7	1	0.691	1.000	1.000
542	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADL(2), ACADM(3), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH6A1(1), AOX1(3), ECHS1(1), EHHADH(2), HADHA(2), HADHB(1), HMGCL(1), IVD(1), MCCC1(2), MCEE(2), MUT(1), PCCA(6), PCCB(1)	6229713	40	22	39	15	11	13	1	7	8	0	0.787	1.000	1.000
543	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(2), F2(1), F5(7), F7(1), F8(7), F9(1), FGA(4), FGB(2), LPA(2), PLAT(1), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(2), VWF(6)	6046167	42	21	42	20	13	15	1	9	4	0	0.927	1.000	1.000
544	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), AOC3(1), DPYD(10), DPYS(2), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HIBCH(1), UPB1(2)	4594991	34	21	33	17	6	10	2	9	7	0	0.943	1.000	1.000
545	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(2), ADRA1B(1), ADRB1(2), ADRB3(2), CHRM2(4), CHRM3(2), CHRM5(1), DRD2(2), DRD3(1), DRD5(4), HRH2(1), HTR1A(2), HTR1B(2), HTR1E(3), HTR2A(5), HTR2C(2), HTR4(2), HTR5A(4), HTR7(1)	4011219	43	21	43	17	16	16	1	6	4	0	0.433	1.000	1.000
546	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(7), EGF(1), EGFR(11), GRB2(2), MAP2K1(2), MAPK3(1), PTPRB(2), RAF1(3), RASA1(4), SHC1(1), SOS1(5), SPRY1(1)	3933965	40	21	40	14	9	8	0	21	2	0	0.735	1.000	1.000
547	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	ABO(2), B3GALNT1(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(1), B4GALT3(2), FUT1(3), FUT2(1), FUT3(2), FUT6(1), FUT9(1), GCNT2(2), PIGG(3), PIGK(2), PIGM(2), PIGN(1), PIGO(2), PIGP(1), PIGS(2), PIGT(2), PIGU(1), PIGV(2), PIGX(2), ST3GAL1(1), ST3GAL6(4), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(3)	7658470	54	20	55	22	16	19	1	10	8	0	0.855	1.000	1.000
548	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), F2(1), F5(7), F8(7), F9(1), FGA(4), FGB(2), KLKB1(3), PROS1(3), SERPING1(2)	7822247	44	20	44	17	11	17	1	10	5	0	0.775	1.000	1.000
549	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN2(2), CXCR3(1), EGF(1), EGFR(11), ITGB1(1), MAPK3(1), MYLK(4), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), TLN1(2)	5566718	35	20	35	17	9	9	0	13	4	0	0.949	1.000	1.000
550	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(3), MAP2K4(4), MAP2K6(1), MAP3K1(3), MAP4K2(1), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TANK(3), TNF(1)	3935858	35	19	35	12	10	12	2	10	1	0	0.620	1.000	1.000
551	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(2), CDK4(1), CDKN1B(2), CDKN2A(2), RB1(16), RBL1(3)	2691378	26	18	25	14	6	2	0	12	6	0	0.961	1.000	1.000
552	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(1), EGFR(11), ERBB3(4), NRG1(7)	1818440	23	18	23	10	5	4	0	12	2	0	0.919	1.000	1.000
553	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(1), ACPP(1), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(1), CYP2A13(1), CYP2A6(4), CYP2A7(3), CYP2C18(2), CYP2C19(1), CYP2C8(2), CYP2C9(3), CYP2D6(1), CYP2E1(2), CYP2F1(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), PON1(1)	4786977	33	18	33	11	13	6	0	10	3	1	0.580	1.000	1.000
554	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), CLYBL(1), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(1), IDH3A(3), OGDH(1), OGDHL(4), PC(4), PCK1(3), SDHA(2), SUCLA2(3), SUCLG1(1)	5075671	30	18	30	14	7	10	0	10	3	0	0.913	1.000	1.000
555	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(1), ACAD9(2), ADH1A(1), ADH1B(3), ADH4(1), ADH5(1), ADH6(1), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ALDH7A1(2), CEL(1), CYP7A1(1), HADHB(1), RDH11(1), RDH12(1), SLC27A5(2)	5301152	31	18	30	13	6	10	1	8	6	0	0.829	1.000	1.000
556	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(2), CUL1(1), NEDD8(1), RB1(16), RBX1(1)	1501449	21	18	20	13	5	1	0	9	6	0	0.983	1.000	1.000
557	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(1), JAK1(2), JAK2(7), JAK3(4), PTPRU(6), REG1A(2)	2571607	24	18	24	10	11	3	0	6	2	2	0.865	1.000	1.000
558	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(7), CASP3(1), CASP8(1), CFLAR(1), MAP2K4(4), MAP3K3(2), MAP3K7(2), NFKB1(3), NFKB2(2), NFKBIE(1), RALBP1(2), TNF(1), TNFAIP3(3)	4296206	32	18	30	12	10	10	1	7	4	0	0.721	1.000	1.000
559	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(4), EGR2(2), GNAQ(1), MAP3K1(3), NFATC1(2), NFATC2(2), NFKB1(3), PLCG1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(1), PRKAR1A(5), PRKAR2A(1), PRKAR2B(2), RELA(1)	4523469	35	18	35	13	16	9	0	6	4	0	0.657	1.000	1.000
560	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(1), IDH3A(3), PC(4), PCK1(3), SDHA(2), SUCLA2(3), SUCLG1(1)	3477598	24	17	24	12	5	9	0	7	3	0	0.935	1.000	1.000
561	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(1), DDX20(1), ETS1(4), ETS2(1), ETV3(1), FOS(1), HDAC5(1), NCOR2(6), RBL1(3), RBL2(2), SIN3A(8), SIN3B(1)	4222434	31	17	29	11	9	9	0	9	4	0	0.719	1.000	1.000
562	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(1), CAD(3), CPS1(8), EPRS(4), GAD1(2), GFPT1(1), GFPT2(1), GLUD2(2), GLUL(1), GOT1(1), GPT(1), GSS(1), PPAT(3), QARS(1)	6723086	30	17	30	14	7	10	2	6	5	0	0.915	1.000	1.000
563	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(4), ALG11(1), ALG14(1), ALG5(1), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(2), DHDDS(2), DPAGT1(2), FUT8(1), GANAB(1), MAN1A1(2), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT4A(1), MGAT4B(1), MGAT5B(1), RPN2(1), STT3B(2)	6822655	36	17	36	17	10	10	1	10	5	0	0.920	1.000	1.000
564	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(2), FUCA1(2), FUCA2(1), GNS(3), HEXA(1), HEXB(2), HPSE(2), HPSE2(4), HYAL2(1), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(1), MANBA(1), NAGLU(1), SPAM1(4)	5375280	35	17	34	15	13	9	0	8	5	0	0.819	1.000	1.000
565	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(3), DLD(1), DLST(1), FH(1), IDH2(1), IDH3A(3), OGDH(1), PC(4), PDHA1(1), PDHA2(3), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(2), SUCLA2(3), SUCLG1(1)	4826227	32	17	32	16	9	11	0	9	3	0	0.944	1.000	1.000
566	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(1), EGFR(11), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(6), RARA(1)	2773802	25	16	23	12	5	6	0	11	3	0	0.970	1.000	1.000
567	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(10), DPYS(2), ENPP3(2), ILVBL(1), PANK3(1), PPCS(2), UPB1(2), VNN1(2)	2819921	23	16	23	12	4	10	1	4	4	0	0.951	1.000	1.000
568	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), CARS(1), DARS(1), DARS2(1), EPRS(4), FARS2(2), FARSB(1), HARS2(2), IARS(1), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(1), NARS2(3), QARS(1), RARS(2), RARS2(3), SARS(1), TARS(3), TARS2(1), WARS(1), WARS2(1), YARS2(1)	9102115	39	16	39	15	8	16	1	9	5	0	0.864	1.000	1.000
569	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(1), ADH1B(3), ADH4(1), ADH6(1), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), CEL(1), CYP7A1(1), HADHB(1)	3931589	22	15	21	12	3	6	1	7	5	0	0.957	1.000	1.000
570	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAX(2), CASP8(1), MAP2K1(2), MAP2K4(4), MAP3K1(3), MAPK3(1), MAPK8(6), NFKB1(3), NSMAF(3), RAF1(3), RELA(1), SMPD1(1)	3442960	30	15	30	11	8	11	1	6	4	0	0.736	1.000	1.000
571	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ADSS(3), AGXT2(1), ASL(2), ASPA(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DARS2(1), DLAT(3), DLD(1), GAD1(2), GOT1(1), GPT(1), NARS(1), NARS2(3), PC(4), PDHA1(1), PDHA2(3)	6299155	36	15	36	22	15	11	1	6	3	0	0.988	1.000	1.000
572	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(3), CAMK2D(1), CLCA1(2), CLCA2(3), CLCA4(1), CNGA3(3), CNGA4(1), GNAL(1), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(2), PRKACA(1), PRKACB(1), PRKACG(1), PRKG1(6), PRKG2(2)	5325391	32	15	32	16	8	14	0	7	3	0	0.908	1.000	1.000
573	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(2), CUL1(1), RB1(16)	1535334	19	15	18	14	3	1	0	10	5	0	0.995	1.000	1.000
574	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A2(1), ECHS1(1), EHHADH(2), GAD1(2), HADHA(2), HMGCL(1), PDHA1(1), PDHA2(3)	4452904	23	14	22	16	7	6	2	5	3	0	0.990	1.000	1.000
575	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(1), CAD(3), CPS1(8), EPRS(4), GAD1(2), GFPT1(1), GLUL(1), GOT1(1), GPT(1), GSS(1), PPAT(3), QARS(1)	5652219	27	14	27	10	7	8	1	6	5	0	0.766	1.000	1.000
576	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT4(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(4), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G12A(1), PLA2G2F(1), PLA2G4A(3), PLA2G6(2), PLD1(3), PLD2(3)	3994212	27	14	27	11	13	8	1	3	2	0	0.724	1.000	1.000
577	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), SLC23A1(1), SLC23A2(1), SLC2A1(2), SLC2A3(1)	4470623	19	14	19	12	7	7	0	2	3	0	0.956	1.000	1.000
578	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR1(2), AGTR2(2), COL4A1(2), COL4A2(2), COL4A3(2), COL4A4(3), COL4A5(4), COL4A6(1), REN(2)	4548161	25	13	25	13	7	12	0	3	3	0	0.941	1.000	1.000
579	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	GNS(3), HEXA(1), HEXB(2), HPSE(2), HPSE2(4), HYAL2(1), LCT(7), NAGLU(1), SPAM1(4)	3306781	25	13	24	10	9	8	0	6	2	0	0.726	1.000	1.000
580	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	DEGS1(1), ENPP7(1), GAL3ST1(2), LCT(7), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(2), SMPD1(1), SMPD4(1), SPHK1(1), SPTLC1(1), UGT8(2)	5317967	24	13	24	14	10	5	0	6	2	1	0.947	1.000	1.000
581	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), BST1(1), CD38(1), ENPP3(2), NADK(3), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(2), NNT(3), NT5C1A(1), NT5C1B(1), NT5C2(2), NT5E(1)	3774751	23	13	23	10	8	5	0	4	6	0	0.869	1.000	1.000
582	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(10), DPYS(2), ENPP3(2), PANK3(1), PPCS(2), UPB1(2)	2239649	20	13	20	10	4	7	1	4	4	0	0.930	1.000	1.000
583	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(4), DUSP1(1), IKBKB(2), MAP3K1(3), NFKB1(3), RELA(1), TANK(3), TNFAIP3(3), TRAF1(2), TRAF3(2)	3802175	24	13	24	12	8	8	0	7	1	0	0.906	1.000	1.000
584	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ADSS(3), AGXT2(1), ASL(2), ASPA(2), CAD(3), CRAT(1), DARS(1), GAD1(2), GOT1(1), GPT(1), NARS(1), PC(4)	4326302	23	12	23	15	9	8	1	3	2	0	0.980	1.000	1.000
585	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(4), DUSP1(1), IKBKB(2), MAP3K1(3), NFKB1(3), RELA(1), TNFAIP3(3), TRAF3(2)	3123517	19	12	19	10	4	8	0	6	1	0	0.946	1.000	1.000
586	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(2), FBP2(1), GOT1(1), GPT(1), ME1(3), ME3(1), PGK2(1), PKLR(1), TKT(1), TKTL1(1), TKTL2(3)	3379409	16	12	16	15	9	3	1	2	1	0	0.994	1.000	1.000
587	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), HEXA(1), HEXB(2), LCT(7), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(2), ST8SIA5(3)	2799392	20	11	20	11	8	6	0	5	1	0	0.903	1.000	1.000
588	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(1), CHUK(4), IKBKB(2), IL2(1), MAP3K1(3), MAP3K5(2), MAPK14(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF9(1)	3296986	25	10	25	10	5	12	1	7	0	0	0.816	1.000	1.000
589	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), MAP2K1(2), MAPK3(1), NFKB1(3), PLCB1(1), PRKCA(3), RAF1(3), RELA(1), TNF(1)	2578201	19	10	19	10	9	3	0	5	2	0	0.871	1.000	1.000
590	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), IKBKB(2), IL1R1(1), MAP3K1(3), MAP3K7(2), MYD88(1), NFKB1(3), RELA(1), TLR4(3), TNF(1), TNFAIP3(3)	3965191	24	10	24	10	6	8	0	9	1	0	0.831	1.000	1.000
591	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	BTK(1), EEA1(4), GSK3B(1), PFKM(3), PFKP(1), PLCG1(2), PRKCE(2), PRKCZ(1), RAB5A(1), VAV2(2)	4056732	18	10	18	12	5	9	0	3	1	0	0.972	1.000	1.000
592	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(1), CHKA(2), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(1)	1117529	11	9	11	7	4	3	0	4	0	0	0.914	1.000	1.000
593	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	GAL3ST1(2), LCT(7), SMPD1(1), SPTLC1(1)	3716848	11	9	11	10	5	2	0	3	1	0	0.989	1.000	1.000
594	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(2), FBP2(1), GOT1(1), GPT(1), ME1(3), ME3(1), PKLR(1), TKT(1)	3007264	11	8	11	12	8	1	0	1	1	0	0.995	1.000	1.000
595	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(1), IDH2(1), OGDH(1), SDHA(2), SUCLA2(3)	1619800	8	8	8	6	0	5	0	3	0	0	0.979	1.000	1.000
596	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), HIF1A(2), JAK2(7), NFKB1(3), RELA(1)	2135638	14	7	14	10	5	1	0	5	2	1	0.989	1.000	1.000
597	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT3(1), CHST11(2), CHST12(2), CHST3(1), DSE(1), UST(2), XYLT1(2)	2070476	11	7	11	9	6	2	0	3	0	0	0.975	1.000	1.000
598	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	EBP(1), FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), SC4MOL(1), SC5DL(2), SQLE(1)	3173163	12	6	13	8	6	5	0	1	0	0	0.938	1.000	1.000
599	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), ILVBL(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(3)	2843530	8	6	8	7	3	2	0	3	0	0	0.982	1.000	1.000
600	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(3), PC(4), PDHA1(1)	1480805	8	6	8	5	6	2	0	0	0	0	0.861	1.000	1.000
601	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), PDE1A(2), PDE1B(1), PLCB1(1), PLCB2(1), PRL(1), TRH(1)	1881264	8	6	8	5	1	5	0	2	0	0	0.926	1.000	1.000
602	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2B5(1), EIF2S3(1), GSK3B(1)	1959086	6	5	6	3	0	3	0	3	0	0	0.876	1.000	1.000
603	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), IL8(1), NFKB1(3), RELA(1), TNF(1)	1720608	8	5	8	6	4	1	1	2	0	0	0.953	1.000	1.000
604	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), MAPK8(6), NFKB1(3), RELA(1), TNFRSF11A(1)	1830014	14	5	14	8	6	5	1	2	0	0	0.918	1.000	1.000
605	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(3)	1742691	7	5	7	4	3	1	0	3	0	0	0.871	1.000	1.000
606	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), HMGCL(1), HMGCS2(1)	1276821	4	4	4	3	3	1	0	0	0	0	0.899	1.000	1.000
607	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1), CES1(1), ESD(1)	1005707	3	3	3	6	0	2	0	1	0	0	0.998	1.000	1.000
608	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1), TNF(1)	875299	3	3	3	4	2	0	0	1	0	0	0.990	1.000	1.000
609	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	GPI(1), PKLR(1)	1459705	2	2	2	4	1	0	0	1	0	0	0.991	1.000	1.000
610	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(2)	753381	2	2	2	3	0	2	0	0	0	0	0.990	1.000	1.000
611	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1B(1), BMPR2(3)	1063548	4	2	4	3	1	1	0	2	0	0	0.951	1.000	1.000
612	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(1)	602223	2	2	2	2	1	1	0	0	0	0	0.943	1.000	1.000
613	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), OAT(1)	889382	2	1	2	2	1	0	0	1	0	0	0.952	1.000	1.000
614	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1), IL2(1)	521899	2	1	2	2	0	2	0	0	0	0	0.969	1.000	1.000
615	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CHEK1(1)	1129050	1	1	1	3	0	0	0	1	0	0	0.997	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		92179	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
