Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q ZFPM1 24 (39%) 38 0.80406 1 0.81625 1 0.71768 1 0.87327 1 0.37583 1 0.74668 1 0.82287 1 0.92127 1 0.38108 1 0.74051 1 LACTB 19 (31%) 43 0.43921 1 0.68712 1 0.68599 1 0.56428 1 1 1 0.31656 1 0.37693 1 0.75049 1 0.32197 1 0.17847 1 CCDC102A 17 (27%) 45 0.01863 1 0.93436 1 0.67029 1 0.50612 1 0.97426 1 0.82493 1 0.49774 1 0.46925 1 0.80829 1 0.50743 1 ZNF517 13 (21%) 49 0.1638 1 0.98064 1 1 1 NA NA 0.82171 1 0.951 1 0.17286 1 0.6939 1 0.7272 1 0.77474 1 MAL2 11 (18%) 51 0.49488 1 0.31341 1 1 1 1 1 0.25148 1 0.5099 1 0.2194 1 0.26746 1 1 1 0.86852 1 CLDN23 10 (16%) 52 0.57145 1 0.25028 1 1 1 0.35142 1 0.02905 1 0.21056 1 0.097699 1 0.18197 1 0.41395 1 0.54473 1 TOR3A 12 (19%) 50 0.61191 1 0.01374 1 0.15278 1 0.31559 1 0.67432 1 0.00482 1 1 1 0.84161 1 0.91063 1 0.8059 1 USP42 15 (24%) 47 0.54936 1 0.04508 1 0.39553 1 0.46634 1 1 1 0.95973 1 0.45836 1 0.8737 1 0.91314 1 0.90224 1 TP53 12 (19%) 50 0.1353 1 0.78898 1 0.39553 1 0.46711 1 0.02035 1 0.66477 1 0.01624 1 0.67195 1 0.0065999 1 0.17957 1 APOE 7 (11%) 55 1 1 0.5984 1 1 1 0.3813 1 0.058299 1 0.39764 1 0.19443 1 0.79114 1 0.4169 1 1 1 ZAR1 11 (18%) 51 0.64743 1 0.66733 1 1 1 0.79282 1 0.62234 1 0.86829 1 0.71415 1 0.97079 1 1 1 0.60312 1 ASPDH 8 (13%) 54 0.30002 1 0.69061 1 1 1 0.31522 1 0.02254 1 0.39258 1 0.47303 1 0.03053 1 0.21219 1 0.081829 1 KCNK17 9 (15%) 53 0.20386 1 0.04028 1 0.01784 1 0.44077 1 0.10484 1 0.0087999 1 0.89072 1 0.54576 1 0.71778 1 0.4458 1 LZTR1 6 (10%) 56 0.051099 1 0.84966 1 1 1 NA NA 0.088389 1 0.11786 1 0.3993 1 0.01476 1 1 1 0.45515 1 ERCC2 10 (16%) 52 1 1 0.22914 1 0.037681 1 0.23353 1 0.47932 1 0.16928 1 0.59733 1 0.27024 1 0.33571 1 0.20781 1 RINL 8 (13%) 54 0.3399 1 0.67739 1 1 1 0.57974 1 0.46837 1 0.27593 1 0.75853 1 0.17162 1 0.35 1 0.74829 1 SYT8 8 (13%) 54 0.4418 1 0.43979 1 1 1 1 1 0.04122 1 0.17745 1 1 1 0.18515 1 0.74968 1 0.4955 1 LRIG1 16 (26%) 46 0.53861 1 0.95881 1 1 1 1 1 0.86534 1 0.61164 1 0.36024 1 0.43413 1 0.57585 1 0.90329 1 C1ORF106 9 (15%) 53 0.84102 1 0.47142 1 0.63889 1 0.04748 1 0.3429 1 0.76027 1 0.47389 1 0.69434 1 0.053609 1 1 1 GPRIN2 8 (13%) 54 0.86776 1 0.38398 1 1 1 0.69283 1 0.68155 1 0.40011 1 0.58033 1 0.75289 1 0.59901 1 0.18095 1 CTNNB1 7 (11%) 55 0.73316 1 0.18424 1 1 1 0.39436 1 0.01818 1 0.02323 1 0.00075999 0.452 0.17846 1 0.1225 1 0.71238 1 C16ORF3 5 (8%) 57 0.85775 1 0.00066999 0.452 1 1 0.78994 1 0.80273 1 0.81341 1 0.581 1 1 1 0.72577 1 0.83568 1 CCDC105 6 (10%) 56 1 1 0.0109 1 0.22619 1 0.67408 1 0.93797 1 0.79395 1 1 1 0.054119 1 0.21764 1 0.20702 1 RGS9BP 8 (13%) 54 0.72559 1 0.63435 1 1 1 0.12991 1 1 1 0.93272 1 0.21811 1 0.96216 1 0.34269 1 0.74916 1 HHIPL1 6 (10%) 56 0.2742 1 0.43337 1 0.48413 1 NA NA 0.62641 1 0.5166 1 0.20406 1 0.42491 1 0.20289 1 0.33306 1 C10ORF95 6 (10%) 56 0.19874 1 0.37897 1 1 1 NA NA 0.51544 1 1 1 0.48628 1 0.36123 1 1 1 1 1 TSC22D2 8 (13%) 54 0.94671 1 0.54328 1 1 1 0.95375 1 0.78214 1 0.81678 1 0.76016 1 0.43156 1 0.34762 1 1 1 NOXA1 5 (8%) 57 0.14074 1 0.51505 1 1 1 NA NA 0.2217 1 0.44097 1 0.29472 1 0.35021 1 0.25436 1 0.72 1 THEM4 5 (8%) 57 0.28005 1 0.76922 1 1 1 NA NA 0.43781 1 0.87599 1 0.1776 1 0.10599 1 0.22881 1 0.25909 1 ATXN1 10 (16%) 52 0.55247 1 0.13887 1 0.6 1 0.91504 1 0.24026 1 0.65767 1 0.28737 1 0.87182 1 0.23475 1 0.31557 1 PLIN5 5 (8%) 57 0.50072 1 0.69604 1 1 1 0.38095 1 0.79998 1 0.66532 1 0.26907 1 0.2689 1 0.5111 1 0.048 1 OPRD1 12 (19%) 50 0.96671 1 0.4361 1 0.65459 1 0.48541 1 0.79969 1 0.95965 1 0.29636 1 0.61417 1 1 1 0.51179 1 KRTAP4-5 5 (8%) 57 0.63233 1 0.28866 1 0.48413 1 NA NA 0.90989 1 0.87662 1 1 1 0.84161 1 0.43579 1 1 1 C19ORF10 7 (11%) 55 0.78115 1 0.42354 1 0.6 1 0.39297 1 0.23959 1 0.12321 1 0.55138 1 0.86081 1 0.63846 1 0.71229 1 AATK 6 (10%) 56 0.13962 1 0.32948 1 1 1 NA NA 0.43686 1 0.35287 1 1 1 0.54483 1 1 1 0.61765 1 SARM1 6 (10%) 56 0.2093 1 0.42297 1 0.6 1 0.69447 1 0.17553 1 0.11378 1 0.26896 1 0.8372 1 0.5103 1 0.079989 1 TRIOBP 10 (16%) 52 0.62124 1 0.22992 1 0.58333 1 0.12896 1 1 1 0.11041 1 0.71122 1 0.87066 1 1 1 0.77425 1 ZNF598 12 (19%) 50 0.10963 1 0.31421 1 1 1 0.74653 1 0.49038 1 0.95086 1 1 1 0.22591 1 0.90216 1 1 1 WDR34 5 (8%) 57 0.62986 1 0.82936 1 0.48413 1 NA NA 0.86521 1 0.8143 1 0.84275 1 0.54836 1 0.84218 1 0.3335 1 ZNF628 7 (11%) 55 0.20954 1 0.92748 1 1 1 0.67575 1 0.31224 1 0.116 1 0.092969 1 0.49999 1 0.28334 1 0.54497 1 BTBD11 6 (10%) 56 1 1 0.31206 1 1 1 NA NA 0.48114 1 1 1 0.48981 1 0.18442 1 0.72436 1 0.33553 1 IRX3 5 (8%) 57 0.14201 1 0.7106 1 0.48413 1 NA NA 0.52078 1 0.11785 1 0.17675 1 0.7777 1 0.23009 1 0.45476 1 FPGS 5 (8%) 57 1 1 1 1 1 1 0.35132 1 0.66455 1 0.5997 1 0.056849 1 0.62209 1 0.82492 1 0.61515 1 MEN1 5 (8%) 57 0.42 1 0.04722 1 0.48413 1 NA NA 0.0128 1 0.0063799 1 0.20271 1 0.04264 1 0.13437 1 0.20362 1 BHLHE22 5 (8%) 57 0.42312 1 0.073519 1 1 1 0.91534 1 0.11902 1 0.81507 1 0.58206 1 0.83639 1 0.72676 1 0.83453 1 DMKN 3 (5%) 59 1 1 0.32645 1 0.46429 1 NA NA 0.61859 1 0.44283 1 0.0064399 1 0.56721 1 0.25463 1 1 1 OBSCN 18 (29%) 44 0.31028 1 0.52072 1 1 1 0.5438 1 0.67109 1 0.80363 1 0.15136 1 0.4974 1 1 1 0.3856 1 PANK2 5 (8%) 57 0.62871 1 0.43153 1 0.22619 1 0.35226 1 0.11564 1 0.051319 1 0.43014 1 0.34797 1 1 1 0.25634 1 RREB1 5 (8%) 57 0.7256 1 0.85223 1 0.20635 1 NA NA 0.61991 1 1 1 0.529 1 0.54552 1 0.17086 1 0.35268 1 RNF149 4 (6%) 58 0.33963 1 0.03643 1 0.58333 1 0.9545 1 0.43768 1 0.60238 1 0.3136 1 0.26058 1 0.6646 1 0.17322 1 GLTPD2 6 (10%) 56 0.87638 1 0.84126 1 0.48413 1 NA NA 0.82928 1 0.39944 1 0.55243 1 0.52657 1 0.87328 1 0.13264 1 SNED1 5 (8%) 57 0.63297 1 0.31458 1 0.46429 1 NA NA 0.39815 1 0.66763 1 0.094149 1 0.66273 1 1 1 0.54447 1 TPO 12 (19%) 50 0.26092 1 0.29865 1 0.10159 1 0.69652 1 0.17247 1 0.12536 1 0.098069 1 0.34403 1 1 1 0.17255 1 PTPLA 4 (6%) 58 0.41786 1 0.32717 1 1 1 NA NA 0.33855 1 0.44108 1 0.77597 1 1 1 0.77463 1 1 1 PRSS27 3 (5%) 59 1 1 0.90775 1 1 1 NA NA 0.61798 1 0.050249 1 0.1307 1 1 1 0.61182 1 0.55353 1 CD320 4 (6%) 58 1 1 0.85082 1 1 1 NA NA 0.73888 1 0.65762 1 0.39966 1 0.22769 1 0.23238 1 0.25995 1 SEMA5B 8 (13%) 54 0.33932 1 0.26798 1 0.31111 1 0.17467 1 0.39983 1 0.21395 1 0.64678 1 0.29689 1 0.35932 1 0.40801 1 CCDC150 4 (6%) 58 0.1772 1 0.8509 1 0.22619 1 0.6047 1 0.23829 1 0.11789 1 0.40158 1 0.21304 1 1 1 0.4531 1 TAF5 4 (6%) 58 1 1 0.77023 1 0.58333 1 0.95349 1 1 1 0.87702 1 0.0099999 1 0.11589 1 0.056599 1 0.01391 1 GARS 19 (31%) 43 0.076309 1 0.091279 1 0.22754 1 0.33486 1 0.34213 1 0.10289 1 0.11632 1 0.40049 1 0.21447 1 0.39684 1 MUC5B 22 (35%) 40 1 1 0.62721 1 1 1 0.81183 1 0.72792 1 0.67129 1 0.71857 1 0.61537 1 1 1 0.52999 1 KIAA1984 4 (6%) 58 0.42159 1 0.70927 1 0.22619 1 0.50184 1 0.12744 1 0.04902 1 0.03105 1 0.58361 1 0.66263 1 0.79231 1 SRPX 3 (5%) 59 0.75333 1 0.11413 1 1 1 NA NA 0.61872 1 1 1 0.77552 1 0.71798 1 1 1 0.39867 1 TNIP2 5 (8%) 57 0.63116 1 0.70694 1 1 1 NA NA 0.74016 1 0.87687 1 1 1 0.41227 1 1 1 0.45322 1 IDUA 8 (13%) 54 0.37965 1 0.85298 1 1 1 0.79311 1 0.51182 1 0.54913 1 0.20188 1 0.43172 1 0.45809 1 0.64817 1 RNF39 5 (8%) 57 0.72423 1 0.37712 1 0.6 1 0.79343 1 0.17508 1 0.26506 1 0.15764 1 0.70163 1 0.23974 1 0.6813 1 PABPC1 4 (6%) 58 0.4176 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA SCRT1 3 (5%) 59 1 1 0.42727 1 0.46429 1 NA NA 0.4731 1 0.61633 1 0.42586 1 0.7936 1 0.46889 1 1 1 MAP1S 5 (8%) 57 0.1571 1 0.27813 1 1 1 0.41523 1 0.39776 1 1 1 1 1 0.83447 1 0.42163 1 0.83668 1 NF1 7 (11%) 55 0.25337 1 0.90311 1 0.10159 1 0.39399 1 0.35893 1 0.18778 1 0.27932 1 0.88285 1 1 1 0.097579 1 AKAP2 4 (6%) 58 0.10727 1 0.43179 1 1 1 0.67533 1 0.73772 1 0.17306 1 0.53068 1 0.44198 1 0.823 1 0.35214 1 NOTCH2 5 (8%) 57 0.28034 1 0.8956 1 1 1 NA NA 0.52184 1 0.11651 1 0.03161 1 0.3189 1 0.66334 1 0.7948 1 FANK1 4 (6%) 58 1 1 0.32465 1 1 1 NA NA 0.85605 1 0.28934 1 0.77822 1 0.22949 1 0.77529 1 0.25763 1 NEFH 6 (10%) 56 0.050259 1 0.17281 1 0.48413 1 NA NA 0.11404 1 0.050279 1 0.40033 1 0.20978 1 0.66546 1 0.45245 1 NPTX1 3 (5%) 59 0.63965 1 1 1 0.46429 1 NA NA 1 1 0.81593 1 0.5835 1 0.79226 1 0.35304 1 0.55585 1 KBTBD13 9 (15%) 53 0.45681 1 0.11485 1 0.31111 1 0.79178 1 0.68663 1 0.11796 1 1 1 0.32793 1 1 1 0.60136 1 RASIP1 6 (10%) 56 0.35864 1 0.34865 1 1 1 NA NA 0.04246 1 0.18736 1 0.056339 1 0.69524 1 0.41403 1 0.71415 1 AR 4 (6%) 58 0.41675 1 0.51451 1 1 1 0.95382 1 0.47626 1 0.44116 1 0.42783 1 1 1 0.25612 1 1 1 KNDC1 9 (15%) 53 0.35362 1 0.065179 1 1 1 0.55099 1 0.02604 1 0.32506 1 0.42089 1 0.36692 1 0.18741 1 0.38132 1 SEZ6L2 8 (13%) 54 0.38222 1 0.66555 1 1 1 0.7879 1 0.82848 1 1 1 0.46212 1 0.62775 1 1 1 0.84799 1 VARS 6 (10%) 56 1 1 0.42251 1 0.22619 1 0.38307 1 0.21456 1 0.066489 1 0.64582 1 0.86314 1 0.74774 1 1 1 IER5 3 (5%) 59 0.19748 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NMU 5 (8%) 57 0.9151 1 1 1 0.46429 1 NA NA 0.070129 1 0.61846 1 1 1 0.54328 1 0.82409 1 0.61698 1 TMEM189 3 (5%) 59 0.19815 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA ADAD2 4 (6%) 58 0.42105 1 0.57517 1 1 1 NA NA 0.73842 1 0.17079 1 0.0089799 1 0.51061 1 0.055849 1 0.35214 1 PLEC 13 (21%) 49 0.42792 1 0.67172 1 0.33333 1 0.04605 1 0.20437 1 0.72031 1 0.59735 1 0.63551 1 0.14242 1 0.62414 1 RGMB 6 (10%) 56 0.65206 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA CLIC6 5 (8%) 57 0.63088 1 1 1 0.20635 1 NA NA 0.66692 1 0.11801 1 0.17787 1 0.58146 1 0.29582 1 1 1 ZNF814 3 (5%) 59 1 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA DSPP 9 (15%) 53 0.6144 1 0.061209 1 1 1 0.69374 1 1 1 0.48133 1 0.44839 1 0.53643 1 0.90113 1 1 1 AMDHD1 10 (16%) 52 0.65627 1 0.75466 1 0.22619 1 0.35145 1 0.58538 1 0.13591 1 0.17403 1 0.85244 1 0.9042 1 0.6813 1 CRIPAK 10 (16%) 52 0.38485 1 0.92643 1 0.6 1 0.93522 1 0.49014 1 0.69002 1 0.89333 1 0.32897 1 0.4765 1 0.36626 1 NOM1 6 (10%) 56 1 1 0.31214 1 1 1 NA NA 0.86487 1 1 1 1 1 0.787 1 0.41968 1 1 1 MAP7 3 (5%) 59 1 1 0.64794 1 0.46429 1 NA NA 1 1 0.81377 1 0.57954 1 0.79321 1 1 1 0.55704 1 PTX4 3 (5%) 59 1 1 1 1 1 1 NA NA 0.47176 1 0.19506 1 0.43145 1 1 1 0.2529 1 0.25443 1 LRP11 6 (10%) 56 1 1 0.081189 1 1 1 NA NA 0.79921 1 0.66341 1 0.57879 1 0.93651 1 0.84024 1 0.83677 1 PDCD6 3 (5%) 59 0.30157 1 0.65038 1 0.46429 1 NA NA NA NA NA NA 1 1 0.64013 1 1 1 1 1 SHOX2 3 (5%) 59 0.41188 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA UQCRFS1 5 (8%) 57 0.74954 1 0.58626 1 0.48413 1 NA NA 1 1 0.87657 1 0.48649 1 0.20396 1 0.84287 1 0.33344 1 CTBP2 3 (5%) 59 0.75427 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA PRKAR1A 6 (10%) 56 0.61561 1 1 1 0.6 1 0.79447 1 0.27882 1 0.3993 1 0.10376 1 0.58696 1 0.04813 1 0.58862 1 JMJD4 3 (5%) 59 1 1 NA NA 0.48413 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA HSD17B1 4 (6%) 58 0.91511 1 0.04994 1 0.58333 1 0.50382 1 0.90743 1 0.0079899 1 1 1 0.84163 1 0.55254 1 0.79363 1 COQ2 5 (8%) 57 0.36198 1 0.76641 1 1 1 NA NA 0.44096 1 0.60045 1 1 1 0.67287 1 0.54948 1 0.61971 1 FEZ2 3 (5%) 59 0.46741 1 0.35245 1 1 1 NA NA 0.22153 1 0.81407 1 0.19315 1 0.79444 1 0.77356 1 0.5532 1 DLEU7 3 (5%) 59 0.52843 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA RNF135 3 (5%) 59 0.75394 1 NA NA 0.46429 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA SPIRE2 3 (5%) 59 0.29865 1 0.03834 1 1 1 NA NA 1 1 0.81473 1 1 1 0.79222 1 1 1 1 1 KRTAP5-5 3 (5%) 59 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA SGK223 3 (5%) 59 0.75534 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA C9ORF66 5 (8%) 57 1 1 0.92602 1 1 1 NA NA 1 1 0.51602 1 0.58124 1 0.93525 1 0.34732 1 0.54228 1 AQP7 3 (5%) 59 0.7551 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA ADAMTS7 4 (6%) 58 0.1997 1 0.47855 1 0.087302 1 0.3495 1 0.091389 1 0.43705 1 0.082449 1 0.26042 1 0.1221 1 0.03907 1 PCDHB13 5 (8%) 57 0.39283 1 0.14139 1 0.48413 1 NA NA 0.12858 1 0.35466 1 0.66673 1 0.060119 1 0.43646 1 0.45302 1 CSGALNACT2 3 (5%) 59 0.16001 1 0.03833 1 0.46429 1 NA NA 0.77324 1 0.81261 1 0.58042 1 0.87401 1 0.34948 1 0.40212 1 HLA-A 3 (5%) 59 1 1 1 1 1 1 NA NA 0.85572 1 0.19586 1 1 1 0.51049 1 0.77569 1 0.25691 1 MTFMT 3 (5%) 59 1 1 NA NA 1 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NLRP5 4 (6%) 58 0.91358 1 0.17046 1 0.46429 1 NA NA 1 1 0.12062 1 0.77743 1 0.64177 1 1 1 0.077159 1 KCNJ11 4 (6%) 58 0.02074 1 0.70531 1 1 1 NA NA 0.43777 1 0.22813 1 0.12631 1 0.053619 1 0.29045 1 0.25894 1