Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	17.0	124.0	7.0	-0.025	0.022	1000.0	-1000.0	-0.015	-1000.0
Class IB PI3K non-lipid kinase events	14.0	42.0	3.0	-0.01	0.01	1000.0	-1000.0	-0.012	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1232.0	93.0	-0.064	0.051	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	13.0	54.0	4.0	-0.042	0.014	1000.0	-1000.0	0.011	-1000.0
Wnt signaling	13.0	95.0	7.0	-0.088	0.012	1000.0	-1000.0	-0.018	-1000.0
HIF-1-alpha transcription factor network	12.0	957.0	76.0	-0.139	0.031	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by the Hedgehog family	11.0	598.0	52.0	-0.099	0.062	1000.0	-1000.0	-0.024	-1000.0
FOXA2 and FOXA3 transcription factor networks	11.0	510.0	46.0	-0.19	0.03	1000.0	-1000.0	-0.055	-1000.0
IL23-mediated signaling events	11.0	667.0	60.0	-0.055	0.101	1000.0	-1000.0	-0.072	-1000.0
IL12-mediated signaling events	10.0	911.0	87.0	-0.106	0.06	1000.0	-1000.0	-0.077	-1000.0
Glypican 1 network	10.0	496.0	48.0	-0.091	0.036	1000.0	-1000.0	-0.026	-1000.0
FOXM1 transcription factor network	10.0	533.0	51.0	-0.161	0.026	1000.0	-1000.0	-0.076	-1000.0
Noncanonical Wnt signaling pathway	9.0	247.0	26.0	-0.088	0.036	1000.0	-1000.0	-0.032	-1000.0
S1P4 pathway	9.0	233.0	25.0	-0.093	0.04	1000.0	-1000.0	-0.017	-1000.0
Thromboxane A2 receptor signaling	8.0	916.0	105.0	-0.067	0.048	1000.0	-1000.0	-0.04	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	686.0	82.0	-0.068	0.03	1000.0	-1000.0	-0.052	-1000.0
S1P5 pathway	8.0	146.0	17.0	-0.093	0.061	1000.0	-1000.0	-0.008	-1000.0
EPHB forward signaling	8.0	718.0	85.0	-0.067	0.062	1000.0	-1000.0	-0.05	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	8.0	572.0	68.0	-0.092	0.05	1000.0	-1000.0	-0.061	-1000.0
S1P3 pathway	8.0	350.0	42.0	-0.111	0.034	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	147.0	17.0	-0.062	0.038	1000.0	-1000.0	-0.014	-1000.0
Osteopontin-mediated events	7.0	274.0	38.0	-0.051	0.026	1000.0	-1000.0	-0.031	-1000.0
BMP receptor signaling	7.0	600.0	81.0	-0.09	0.039	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	7.0	402.0	55.0	-0.056	0.027	1000.0	-1000.0	-0.035	-1000.0
PDGFR-alpha signaling pathway	7.0	340.0	44.0	-0.055	0.036	1000.0	-1000.0	-0.027	-1000.0
Ephrin B reverse signaling	7.0	348.0	48.0	-0.047	0.041	1000.0	-1000.0	-0.031	-1000.0
Endothelins	7.0	752.0	96.0	-0.198	0.039	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	308.0	44.0	-0.071	0.034	1000.0	-1000.0	-0.027	-1000.0
Nongenotropic Androgen signaling	7.0	394.0	52.0	-0.117	0.036	1000.0	-1000.0	-0.031	-1000.0
Aurora B signaling	7.0	473.0	67.0	-0.122	0.024	1000.0	-1000.0	-0.031	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	647.0	97.0	-0.064	0.032	1000.0	-1000.0	-0.051	-1000.0
amb2 Integrin signaling	6.0	561.0	82.0	-0.037	0.049	1000.0	-1000.0	-0.025	-1000.0
S1P1 pathway	6.0	248.0	36.0	-0.105	0.024	1000.0	-1000.0	-0.03	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	198.0	31.0	-0.013	0.092	1000.0	-1000.0	-0.05	-1000.0
LPA receptor mediated events	6.0	710.0	102.0	-0.087	0.036	1000.0	-1000.0	-0.062	-1000.0
IL6-mediated signaling events	6.0	497.0	75.0	-0.178	0.042	1000.0	-1000.0	-0.036	-1000.0
BCR signaling pathway	6.0	611.0	99.0	-0.081	0.042	1000.0	-1000.0	-0.066	-1000.0
EGFR-dependent Endothelin signaling events	6.0	144.0	21.0	-0.055	0.033	1000.0	-1000.0	-0.035	-1000.0
IGF1 pathway	6.0	381.0	57.0	-0.054	0.047	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	6.0	568.0	86.0	-0.219	0.064	1000.0	-1000.0	-0.04	-1000.0
Syndecan-1-mediated signaling events	5.0	197.0	34.0	-0.035	0.05	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	5.0	334.0	62.0	-0.072	0.056	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PTP1B	5.0	427.0	76.0	-0.073	0.042	1000.0	-1000.0	-0.026	-1000.0
IL4-mediated signaling events	5.0	520.0	91.0	-0.176	0.049	1000.0	-1000.0	-0.083	-1000.0
PLK1 signaling events	5.0	468.0	85.0	-0.059	0.032	1000.0	-1000.0	-0.026	-1000.0
Syndecan-3-mediated signaling events	5.0	206.0	35.0	-0.07	0.068	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	5.0	293.0	58.0	-0.047	0.04	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	5.0	449.0	84.0	-0.059	0.053	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by STAT5	5.0	117.0	22.0	-0.098	0.038	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	5.0	370.0	67.0	-0.042	0.05	1000.0	-1000.0	-0.031	-1000.0
Caspase cascade in apoptosis	4.0	315.0	74.0	-0.027	0.053	1000.0	-1000.0	-0.029	-1000.0
Coregulation of Androgen receptor activity	4.0	362.0	76.0	-0.091	0.045	1000.0	-1000.0	-0.02	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	162.0	34.0	-0.025	0.053	1000.0	-1000.0	-0.023	-1000.0
Syndecan-2-mediated signaling events	4.0	295.0	69.0	-0.035	0.034	1000.0	-1000.0	-0.035	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	22.0	5.0	0.018	0.031	1000.0	-1000.0	0.01	-1000.0
p75(NTR)-mediated signaling	4.0	624.0	125.0	-0.124	0.064	1000.0	-1000.0	-0.056	-1000.0
Aurora C signaling	4.0	31.0	7.0	-0.02	0.014	1000.0	-1000.0	-0.009	-1000.0
Glucocorticoid receptor regulatory network	4.0	532.0	114.0	-0.132	0.049	1000.0	-1000.0	-0.046	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	150.0	37.0	-0.058	0.055	1000.0	-1000.0	-0.024	-1000.0
Reelin signaling pathway	4.0	230.0	56.0	-0.052	0.066	1000.0	-1000.0	-0.031	-1000.0
TCGA08_p53	4.0	30.0	7.0	-0.016	0.026	1000.0	-1000.0	-0.011	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	73.0	15.0	-0.077	0.023	1000.0	-1000.0	-0.029	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	437.0	88.0	-0.114	0.034	1000.0	-1000.0	-0.055	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	511.0	120.0	-0.103	0.082	1000.0	-1000.0	-0.042	-1000.0
Visual signal transduction: Rods	4.0	233.0	52.0	-0.054	0.048	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	319.0	78.0	-0.051	0.052	1000.0	-1000.0	-0.031	-1000.0
LPA4-mediated signaling events	3.0	38.0	12.0	-0.018	0.013	1000.0	-1000.0	-0.018	-1000.0
ErbB2/ErbB3 signaling events	3.0	229.0	65.0	-0.056	0.033	1000.0	-1000.0	-0.05	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	110.0	28.0	-0.093	0.047	1000.0	-1000.0	-0.021	-1000.0
Visual signal transduction: Cones	3.0	140.0	38.0	-0.016	0.049	1000.0	-1000.0	-0.024	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	165.0	54.0	-0.022	0.053	1000.0	-1000.0	-0.041	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	58.0	17.0	-0.022	0.057	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	313.0	85.0	-0.063	0.059	1000.0	-1000.0	-0.047	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	230.0	65.0	-0.103	0.044	1000.0	-1000.0	-0.031	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	200.0	61.0	-0.065	0.064	1000.0	-1000.0	-0.034	-1000.0
Nectin adhesion pathway	3.0	243.0	63.0	-0.045	0.052	1000.0	-1000.0	-0.046	-1000.0
TRAIL signaling pathway	3.0	172.0	48.0	-0.044	0.05	1000.0	-1000.0	-0.026	-1000.0
IL1-mediated signaling events	3.0	215.0	62.0	-0.03	0.062	1000.0	-1000.0	-0.049	-1000.0
ceramide signaling pathway	3.0	194.0	49.0	-0.027	0.046	1000.0	-1000.0	-0.025	-1000.0
HIF-2-alpha transcription factor network	3.0	139.0	43.0	-0.073	0.045	1000.0	-1000.0	-0.041	-1000.0
FAS signaling pathway (CD95)	3.0	155.0	47.0	-0.044	0.036	1000.0	-1000.0	-0.031	-1000.0
Canonical Wnt signaling pathway	3.0	190.0	51.0	-0.062	0.058	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	3.0	176.0	54.0	-0.061	0.054	1000.0	-1000.0	-0.044	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	237.0	74.0	-0.047	0.056	1000.0	-1000.0	-0.055	-1000.0
Class I PI3K signaling events	3.0	252.0	73.0	-0.032	0.049	1000.0	-1000.0	-0.031	-1000.0
PDGFR-beta signaling pathway	3.0	355.0	97.0	-0.055	0.057	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling in keratinocytes	3.0	144.0	43.0	-0.02	0.051	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	2.0	163.0	69.0	-0.065	0.035	1000.0	-1000.0	-0.034	-1000.0
BARD1 signaling events	2.0	129.0	57.0	-0.048	0.041	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	2.0	44.0	22.0	-0.046	0.023	1000.0	-1000.0	-0.025	-1000.0
Cellular roles of Anthrax toxin	2.0	97.0	39.0	-0.066	0.025	1000.0	-1000.0	-0.02	-1000.0
mTOR signaling pathway	2.0	152.0	53.0	-0.049	0.026	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	2.0	190.0	68.0	-0.062	0.061	1000.0	-1000.0	-0.045	-1000.0
Ceramide signaling pathway	2.0	222.0	76.0	-0.067	0.056	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class III	2.0	95.0	40.0	-0.044	0.048	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	153.0	52.0	-0.041	0.068	1000.0	-1000.0	-0.032	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	195.0	83.0	-0.028	0.043	1000.0	-1000.0	-0.026	-1000.0
Retinoic acid receptors-mediated signaling	2.0	152.0	58.0	-0.042	0.041	1000.0	-1000.0	-0.031	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	87.0	36.0	-0.036	0.054	1000.0	-1000.0	-0.032	-1000.0
Atypical NF-kappaB pathway	2.0	67.0	31.0	-0.019	0.038	1000.0	-1000.0	-0.026	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	99.0	45.0	-0.026	0.047	1000.0	-1000.0	-0.039	-1000.0
Effects of Botulinum toxin	2.0	77.0	26.0	-0.019	0.043	1000.0	-1000.0	-0.014	-1000.0
IL27-mediated signaling events	2.0	152.0	51.0	-0.047	0.039	1000.0	-1000.0	-0.044	-1000.0
TCGA08_rtk_signaling	2.0	73.0	26.0	-0.019	0.048	1000.0	-1000.0	-0.007	-1000.0
Regulation of Telomerase	2.0	248.0	102.0	-0.134	0.049	1000.0	-1000.0	-0.031	-1000.0
Insulin Pathway	2.0	174.0	74.0	-0.103	0.062	1000.0	-1000.0	-0.044	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	85.0	33.0	-0.019	0.056	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	2.0	56.0	20.0	-0.003	0.037	1000.0	-1000.0	-0.012	-1000.0
E-cadherin signaling events	2.0	12.0	5.0	0.021	0.052	1000.0	-1000.0	0.011	-1000.0
Regulation of Androgen receptor activity	2.0	208.0	70.0	-0.126	0.038	1000.0	-1000.0	-0.036	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	267.0	136.0	-0.064	0.067	1000.0	-1000.0	-0.024	-1000.0
Canonical NF-kappaB pathway	1.0	42.0	39.0	-0.019	0.043	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class II	1.0	102.0	75.0	-0.023	0.053	1000.0	-1000.0	-0.028	-1000.0
Aurora A signaling	1.0	95.0	60.0	-0.061	0.044	1000.0	-1000.0	-0.026	-1000.0
Insulin-mediated glucose transport	1.0	54.0	32.0	-0.046	0.042	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	77.0	68.0	-0.034	0.054	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class I	1.0	107.0	104.0	-0.045	0.054	1000.0	-1000.0	-0.028	-1000.0
FoxO family signaling	1.0	99.0	64.0	-0.056	0.035	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	211.0	125.0	-0.046	0.053	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	124.0	76.0	-0.037	0.06	1000.0	-1000.0	-0.051	-1000.0
TCGA08_retinoblastoma	1.0	11.0	8.0	-0.005	0.026	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by PRL	1.0	53.0	34.0	-0.034	0.034	1000.0	-1000.0	-0.039	-1000.0
p38 MAPK signaling pathway	1.0	72.0	44.0	-0.018	0.041	1000.0	-1000.0	-0.019	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	12.0	23.0	-0.016	0.041	1000.0	-1000.0	-0.026	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.019	-1000.0	1000.0	-1000.0	-0.022	-1000.0
Arf6 downstream pathway	0.0	14.0	43.0	-0.042	0.043	1000.0	-1000.0	-0.021	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.021	0.047	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	0.0	61.0	71.0	-0.029	0.04	1000.0	-1000.0	-0.029	-1000.0
VEGFR1 specific signals	0.0	43.0	56.0	-0.032	0.048	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	0.0	32.0	54.0	-0.011	0.041	1000.0	-1000.0	-0.015	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.057	1000.0	-1000.0	-0.0	-1000.0
Total	578	34761	7203	-7.94886275681	-994.189028475	131000	-131000	-4.23459672666	-131000