rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(9), CDKN2A(30), E2F1(3), MDM2(6), MYC(2), PIK3CA(94), PIK3R1(7), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), RAC1(4), RB1(73), TBX2(7), TP53(226) 11787713 493 271 310 38 182 13 102 37 151 8 <1.00e-15 <1.00e-15 <1.48e-13 2 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(7), ATM(65), BAX(2), CCND1(4), CCNE1(3), CDK2(1), CDK4(6), CDKN1A(38), E2F1(3), GADD45A(1), MDM2(6), PCNA(4), RB1(73), TP53(226) 10569238 439 266 312 31 118 9 95 30 173 14 1.07e-12 <1.00e-15 <1.48e-13 3 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), RB1(73), SKP2(5), TFDP1(2) 4966858 111 101 99 9 29 1 8 5 62 6 0.000161 <1.00e-15 <1.48e-13 4 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), HSPA1A(3), IFNG(2), IFNGR1(1), IFNGR2(6), IKBKB(11), JAK2(8), LIN7A(3), NFKB1(3), NFKBIA(6), RB1(73), RELA(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TP53(226), USH1C(10), WT1(4) 10415274 380 237 263 31 112 7 91 22 140 8 6.85e-14 1.33e-15 1.48e-13 5 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(4), MYC(2), SP1(10), SP3(3), TP53(226), WT1(4) 4101874 249 205 141 21 69 6 80 21 71 2 3.73e-09 1.33e-15 1.48e-13 6 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(16), AKT1(3), ATM(65), BAX(2), CDKN1A(38), CPB2(5), CSNK1A1(6), CSNK1D(3), FHL2(4), GADD45A(1), HIF1A(6), HSPA1A(3), IGFBP3(1), MAPK8(5), MDM2(6), NFKBIB(6), TP53(226) 12077203 396 261 276 37 124 11 102 32 119 8 2.30e-09 1.44e-15 1.48e-13 7 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(50), DAXX(9), HRAS(21), PAX3(11), PML(14), RARA(6), RB1(73), SIRT1(9), SP100(13), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TP53(226) 10972480 447 258 318 32 119 5 124 30 160 9 <1.00e-15 2.11e-15 1.86e-13 8 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(65), ATR(32), CDC25C(2), CHEK1(3), CHEK2(11), TP53(226), YWHAH(2) 9369284 341 240 229 22 113 10 92 34 88 4 1.12e-10 3.00e-15 2.13e-13 9 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CDK2(1), CDK4(6), CHEK1(3), MYT1(10), RB1(73), TP53(226), WEE1(10), YWHAH(2) 10260649 405 252 287 31 112 10 93 32 149 9 8.30e-12 3.11e-15 2.13e-13 10 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(9), ATM(65), ATR(32), CCNA1(4), CCND1(4), CCNE1(3), CDC25A(5), CDK2(1), CDK4(6), CDK6(5), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), E2F1(3), GSK3B(5), HDAC1(4), RB1(73), SKP2(5), TFDP1(2), TGFB1(3), TGFB3(1), TP53(226) 17514723 533 279 396 42 158 15 113 39 193 15 2.11e-15 4.22e-15 2.45e-13 11 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(7), DNAJC3(6), EIF2S1(5), EIF2S2(1), NFKB1(3), NFKBIA(6), RELA(6), TP53(226) 5652096 260 206 152 13 82 5 81 17 73 2 2.19e-13 4.66e-15 2.45e-13 12 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF3(1), CCND1(4), CDK2(1), CDK4(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CFL1(1), E2F1(3), E2F2(4), MDM2(6), PRB1(2), TP53(226) 4836827 328 232 203 24 89 7 93 18 114 7 6.20e-13 4.77e-15 2.45e-13 13 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), FBXW7(38), RB1(73), TFDP1(2) 4802111 140 119 118 11 36 1 18 5 74 6 2.71e-05 6.00e-15 2.84e-13 14 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNH(4), CDC25A(5), CDK2(1), CDK4(6), CDK6(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), CDKN2C(2), CDKN2D(1), E2F1(3), RB1(73), RBL1(9), TFDP1(2) 9246340 219 158 193 22 60 6 24 9 109 11 6.34e-05 3.59e-12 1.58e-10 15 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CCND1(4), CCNE1(3), CDK2(1), CDK4(6), CDK6(5), CDKN1A(38), CDKN1B(6), E2F1(3), HRAS(21), MAPK3(8), NFKB1(3), NFKBIA(6), PAK1(4), PIK3CA(94), PIK3R1(7), RAC1(4), RAF1(4), RB1(73), RELA(6), TFDP1(2) 11750042 301 205 217 31 125 7 29 24 105 11 1.30e-07 8.32e-08 3.42e-06 16 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(1), CDKN1B(6), CUL1(19), E2F1(3), NEDD8(2), RB1(73), RBX1(1), SKP2(5), TFDP1(2), UBE2M(3) 4996097 118 100 106 14 32 1 8 6 65 6 0.00299 2.30e-07 8.85e-06 17 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(5), AKT3(8), CDKN1A(38), ELK1(1), GRB2(3), HRAS(21), MAP2K1(3), MAP2K2(5), NGFR(4), NTRK1(7), PIK3CA(94), PIK3CD(7), SHC1(8), SOS1(23) 9361623 230 160 154 27 122 4 35 26 38 5 1.77e-06 7.98e-06 0.000289 18 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(9), ATM(65), BRCA1(23), CDKN1A(38), CHEK1(3), CHEK2(11), GADD45A(1), JUN(4), MAPK8(5), MDM2(6), MRE11A(7), NFKB1(3), NFKBIA(6), RAD50(13), RAD51(7), RBBP8(11), RELA(6), TP53(226), TP73(6) 17377980 450 276 327 39 163 10 107 35 127 8 8.39e-10 1.28e-05 0.000439 19 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(5), CDC25B(2), CDK7(6), CDKN1A(38), CHEK1(3), NEK1(5), WEE1(10) 3964352 69 57 61 8 24 5 3 0 32 5 0.415 9.16e-05 0.00297 20 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(2), NFYB(1), NFYC(1), RB1(73), SP1(10), SP3(3) 3897027 90 81 83 12 12 2 1 6 63 6 0.0694 0.000157 0.00484 21 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(7), ATM(65), BAD(3), BAX(2), BCL2L1(4), BID(2), CASP3(3), CASP6(1), CASP7(5), CASP9(6), CYCS(1), EIF2S1(5), PRKCA(3), PTK2(15), PXN(3), STAT1(13), TLN1(17), TP53(226) 15945862 384 249 271 42 134 14 103 31 99 3 1.72e-09 0.000301 0.00884 22 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(9), GH1(3), GHR(6), HRAS(21), IGF1(2), IGF1R(11), PIK3CA(94), PIK3R1(7), SHC1(8), SOD1(4), SOD2(1), SOD3(1) 7753212 170 134 103 22 93 3 36 22 16 0 2.95e-05 0.00167 0.0467 23 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(7), IGF1R(11), MYC(2), POLR2A(13), PPP2CA(2), PRKCA(3), RB1(73), TEP1(14), TERF1(5), TERT(4), TNKS(6), TP53(226), XRCC5(1) 16355141 370 235 255 48 97 6 102 24 133 8 3.71e-09 0.00239 0.0641 24 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), PAK1(4), PDGFRA(16), PIK3CA(94), PIK3R1(7), RAC1(4), WASL(2) 7841607 151 125 92 17 95 5 15 19 17 0 0.000102 0.0219 0.562 25 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(4), CD3E(2), CD3G(2), CD80(2), CD86(6), CTLA4(1), GRB2(3), HLA-DRA(4), HLA-DRB1(1), ICOS(2), IL2(1), ITK(6), LCK(2), PIK3CA(94), PIK3R1(7), PTPN11(4) 7502326 141 115 82 16 91 4 18 21 7 0 4.49e-05 0.0249 0.615 26 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(50), EP300(77), ESR1(5), MAPK3(8), PELP1(5), SRC(5) 8473831 150 120 142 22 46 6 27 17 52 2 0.00182 0.0580 1.000 27 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(3), CHRNB1(6), CHRNG(2), MUSK(9), PIK3CA(94), PIK3R1(7), PTK2(15), PTK2B(6), RAPSN(2), SRC(5), TERT(4), YWHAH(2) 9421423 158 122 99 21 96 11 19 19 13 0 4.99e-06 0.105 1.000 28 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(3), CASP9(6), CHUK(7), GH1(3), GHR(6), NFKB1(3), NFKBIA(6), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), RELA(6), YWHAH(2) 8186059 150 115 91 18 99 7 15 16 13 0 0.000246 0.206 1.000 29 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), AKT2(5), AKT3(8), BPNT1(2), GRB2(3), ILK(3), MAPK3(8), PDK1(2), PIK3CA(94), PIK3CD(7), PTEN(16), PTK2B(6), RBL2(9), SHC1(8), SOS1(23) 11890301 197 149 136 25 126 6 23 25 17 0 6.85e-06 0.418 1.000 30 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(8) 1005449 8 8 8 0 3 0 3 0 2 0 0.130 0.493 1.000 31 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7), CYP2C9(3) 1188571 10 10 10 2 3 0 6 0 1 0 0.372 0.587 1.000 32 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), BCAR1(6), CDKN1B(6), GRB2(3), ILK(3), ITGB1(3), MAPK3(8), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PTEN(16), PTK2(15), SHC1(8), SOS1(23) 11221555 199 150 138 24 125 8 22 22 22 0 6.47e-05 0.656 1.000 33 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(3), HRAS(21), PTK2B(6), SHC1(8), SOS1(23), SRC(5) 5118084 66 53 57 9 28 1 21 7 9 0 0.0160 0.680 1.000 34 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), GRB2(3), HRAS(21), KLK2(1), NTRK1(7), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), SHC1(8), SOS1(23) 9107325 182 145 114 29 110 4 32 22 14 0 0.000571 0.690 1.000 35 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(94), PIK3R1(7), PLCB1(17), PLCG1(12), PRKCA(3), VAV1(8) 7511540 144 120 85 21 98 4 18 17 7 0 0.000732 0.702 1.000 36 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(5), LIPT1(1) 897135 6 5 6 0 4 1 1 0 0 0 0.293 0.735 1.000 37 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NFS1(5), THTPA(2), TPK1(4) 3725882 35 32 35 4 20 0 5 5 5 0 0.0696 0.750 1.000 38 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(65), ATR(32), BRCA1(23), CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CDC34(1), CDKN1A(38), CDKN2D(1), CHEK1(3), CHEK2(11), EP300(77), GADD45A(1), MDM2(6), MYT1(10), PRKDC(35), RPS6KA1(5), TP53(226), WEE1(10), YWHAH(2), YWHAQ(3) 24351420 563 290 438 59 195 21 125 52 160 10 2.56e-10 0.763 1.000 39 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4) 3308380 25 24 25 3 11 1 6 2 5 0 0.0653 0.784 1.000 40 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 299386 1 1 1 0 1 0 0 0 0 0 0.748 0.790 1.000 41 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(3), FMOD(3), KERA(7), LUM(2) 2112006 17 16 17 2 9 0 5 2 1 0 0.0853 0.802 1.000 42 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(9), IFNG(2), IL12A(1), IL12B(3), IL2(1) 1737741 16 16 16 3 9 0 4 1 2 0 0.326 0.837 1.000 43 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(8), GOT1(2), TAT(5), TYR(12) 2741084 27 23 27 4 12 1 9 1 4 0 0.0860 0.846 1.000 44 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(3), GNB1(7), HTR2C(1), PLCB1(17), TUB(4) 4164702 34 31 33 4 19 2 9 3 1 0 0.0217 0.876 1.000 45 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(4), CCNA2(3), CCND1(4), CCNE1(3), CCNE2(8), CDK2(1), CDK4(6), CDKN1B(6), CDKN2A(30), E2F1(3), E2F2(4), E2F4(2), PRB1(2) 5142241 76 60 67 11 32 5 13 2 24 0 0.0308 0.877 1.000 46 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(12), SPCS3(1) 1788894 15 15 15 4 7 1 4 1 2 0 0.394 0.887 1.000 47 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4E(2), EIF4EBP1(1), GSK3B(5), IGF1(2), IGF1R(11), INPPL1(11), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), PTEN(16), RPS6(5), RPS6KB1(4) 11452183 190 143 130 26 118 4 26 18 23 1 5.08e-05 0.902 1.000 48 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(4), CD4(3), HLA-DRA(4), HLA-DRB1(1) 1383675 12 12 12 4 6 1 3 2 0 0 0.498 0.946 1.000 49 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(4), BIRC3(3), CASP8(14), FADD(7), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 4817772 57 49 55 9 36 1 7 4 9 0 0.0280 0.946 1.000 50 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(6), IDI1(2), SQLE(4) 1843674 12 12 12 2 6 0 3 2 1 0 0.313 0.969 1.000 51 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 664914 4 3 4 3 1 0 2 0 1 0 0.943 0.975 1.000 52 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(6), CES1(4), ESD(3) 3501402 18 18 18 3 7 0 5 4 2 0 0.191 0.988 1.000 53 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(5) 1526099 7 7 7 2 4 0 0 1 2 0 0.615 0.989 1.000 54 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(7), CPS1(13), GLS(4), GLUD1(6), GOT1(2) 4538906 34 28 32 5 18 1 5 5 5 0 0.0719 0.992 1.000 55 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL5(1) 1774605 10 10 10 4 3 0 4 2 1 0 0.723 0.996 1.000 56 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(10), NR0B2(2), NR1H3(4), NR1H4(4), RXRA(25) 3161192 46 41 33 10 22 3 10 2 9 0 0.0802 0.998 1.000 57 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(2), HGD(4) 1306225 9 9 9 4 5 0 0 2 2 0 0.814 0.998 1.000 58 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(7), CYP11A1(1), CYP11B2(13), CYP17A1(3), HSD11B2(3), HSD3B1(5), HSD3B2(5) 4025170 37 32 37 8 19 1 13 4 0 0 0.0452 0.998 1.000 59 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDPS(6), HMGCR(7), IDI1(2), LSS(7), MVD(4), NQO2(3), PMVK(1), SQLE(4), VKORC1(4) 6362305 41 36 41 5 22 2 7 5 5 0 0.0123 0.999 1.000 60 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(6), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5) 5333840 48 39 48 9 24 3 15 5 1 0 0.0186 0.999 1.000 61 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(6), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5) 5333840 48 39 48 9 24 3 15 5 1 0 0.0186 0.999 1.000 62 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(5), CCL2(1), CSF1(4), IL6(4), LDLR(10), LPL(4) 3116487 28 28 28 7 14 0 4 2 8 0 0.364 0.999 1.000 63 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(2) 1229445 5 5 5 3 1 1 2 1 0 0 0.889 0.999 1.000 64 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), AKT1(3), ANXA1(5), CALM1(2), CALM2(2), GNAS(12), GNB1(7), NFKB1(3), NOS3(11), NPPA(2), NR3C1(6), PIK3CA(94), PIK3R1(7), RELA(6), SYT1(6) 10354522 169 135 108 27 118 8 15 17 11 0 0.00395 0.999 1.000 65 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(3), UGDH(5), UGP2(9), UXS1(3) 2849723 23 21 21 5 9 3 3 3 5 0 0.411 1.000 1.000 66 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(38), EPO(2), EPOR(5), GRIN1(9), HIF1A(6), JAK2(8), NFKB1(3), NFKBIA(6), RELA(6), SOD2(1) 7299863 93 80 84 15 40 3 9 3 33 5 0.214 1.000 1.000 67 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(6), JAK1(9), JAK2(8), STAT1(13) 4799687 39 35 38 7 17 1 7 3 11 0 0.182 1.000 1.000 68 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), JUN(4), KLK2(1), MAP2K1(3), MAPK3(8), MAPK8(5), NGFR(4), PIK3CA(94), PIK3R1(7), PLCG1(12), RAF1(4), SHC1(8), SOS1(23) 11130377 213 153 143 30 124 7 33 28 21 0 4.00e-05 1.000 1.000 69 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(2), SNAP25(4), STX1A(1), VAMP2(1) 1901498 10 10 10 4 5 1 3 1 0 0 0.634 1.000 1.000 70 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(4), GLUD1(6), GLUD2(10) 2657960 24 22 23 6 10 1 7 2 4 0 0.481 1.000 1.000 71 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(65), ATR(32), BRCA1(23), BRCA2(49), CHEK1(3), CHEK2(11), FANCA(18), FANCC(9), FANCD2(19), FANCE(3), FANCF(4), FANCG(5), HUS1(1), MRE11A(7), RAD1(3), RAD17(6), RAD50(13), RAD51(7), RAD9A(2), TP53(226), TREX1(8) 25798997 514 268 399 53 208 21 119 49 112 5 1.24e-09 1.000 1.000 72 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(4), CD4(3), CD80(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(1) 2318348 16 16 16 5 9 1 4 2 0 0 0.422 1.000 1.000 73 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(7), ITGB1(3), KLRC2(3), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(3), MAPK3(8), PAK1(4), PIK3CA(94), PIK3R1(7), PTK2B(6), PTPN6(2), RAC1(4), SYK(8), VAV1(8) 10835754 166 134 106 28 100 5 19 22 20 0 0.00351 1.000 1.000 74 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(5), ACAT2(1), HMGCL(1), OXCT1(4) 1983004 11 10 11 7 7 1 0 1 2 0 0.975 1.000 1.000 75 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT2(6), FUT3(3), FUT5(5), FUT6(2), ST3GAL3(3) 2957408 22 21 21 6 13 0 7 0 2 0 0.230 1.000 1.000 76 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(5), BLVRB(1), HMOX1(3), IL10(1), IL10RA(9), IL10RB(9), IL1A(1), IL6(4), JAK1(9), STAT1(13), STAT3(6), STAT5A(1), TNF(4) 7122262 66 56 65 12 29 0 12 3 22 0 0.0107 1.000 1.000 77 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), RAC1(4), WASF1(5), WASL(2) 4739468 39 35 39 7 19 3 5 4 8 0 0.207 1.000 1.000 78 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(3), BCL2L1(4), CASP9(6), CDC42(4), CHUK(7), ELK1(1), H2AFX(3), HRAS(21), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3CA(94), PIK3R1(7), RAC1(4), RAF1(4), RALA(2), RALBP1(2), RALGDS(4), RELA(6), RHOA(19) 11021344 208 149 136 33 119 8 32 24 25 0 0.000491 1.000 1.000 79 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(3), GGT1(5), SHMT1(3), SHMT2(2) 2375220 13 11 13 9 5 0 5 0 3 0 0.936 1.000 1.000 80 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(3), HRAS(21), MAPK3(8), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), NTRK1(7), PIK3CA(94), PIK3R1(7), PLCG1(12), RPS6KA1(5), SHC1(8) 10984337 189 145 122 32 110 7 37 17 18 0 0.000149 1.000 1.000 81 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TPO(16), TYR(12) 5592311 63 50 62 14 30 3 19 4 6 1 0.0579 1.000 1.000 82 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(1), RAB3A(2), RAB5A(2), RAB6A(5), RAB9A(1) 2475444 17 15 17 6 7 2 2 3 3 0 0.791 1.000 1.000 83 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(6), AKT1(3), BAD(3), BAX(2), BCL2L1(4), CSF2RB(5), IGF1(2), IGF1R(11), IL3RA(6), KIT(9), KITLG(5), PIK3CA(94), PIK3R1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), YWHAH(2) 12778665 181 136 121 30 97 8 27 23 26 0 0.000106 1.000 1.000 84 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(3), FDPS(6), HMGCR(7), HMGCS1(9), IDI1(2), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4) 7606406 50 44 50 8 28 2 8 8 4 0 0.0289 1.000 1.000 85 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(50), EP300(77), FYN(7), IL2RG(5), IL7(1), IL7R(7), JAK1(9), JAK3(12), LCK(2), NMI(4), PIK3CA(94), PIK3R1(7), PTK2B(6), STAT5A(1), STAT5B(5) 16206499 287 197 221 46 127 11 43 36 68 2 3.46e-05 1.000 1.000 86 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(6), GOT1(2), PAH(11), TAT(5), YARS(5), YARS2(8) 5069669 40 37 40 9 17 2 5 7 9 0 0.201 1.000 1.000 87 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(3), UGDH(5), UXS1(3) 2231739 14 13 14 5 4 2 3 3 2 0 0.770 1.000 1.000 88 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(1), EHHADH(6), HADHA(4), SDS(2) 2817763 15 15 15 8 11 1 0 0 3 0 0.918 1.000 1.000 89 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(3), B3GALT5(3), B3GNT5(8), FUT1(3), FUT2(6), FUT3(3), ST3GAL3(3), ST3GAL4(1) 4212211 32 23 32 9 22 0 7 1 2 0 0.265 1.000 1.000 90 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(13), GABARAP(3), GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPHN(5), NSF(6), SRC(5), UBQLN1(5) 6922805 88 70 87 18 29 4 25 19 11 0 0.0798 1.000 1.000 91 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(6), GGPS1(1), IDI1(2), IDI2(4), SQLE(4) 2479141 17 17 17 5 7 0 6 3 1 0 0.587 1.000 1.000 92 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(50), EP300(77), LPL(4), NCOA1(25), NCOA2(12), PPARG(13), RXRA(25) 10761211 206 148 183 31 78 8 34 20 64 2 0.00273 1.000 1.000 93 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(6), ACAT1(5), ECHS1(1), HADHA(4) 3151489 19 19 19 8 11 0 3 2 3 0 0.874 1.000 1.000 94 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(6), ALDOB(3), ALDOC(2), TPI1(1) 2282528 12 12 12 9 5 1 3 2 1 0 0.979 1.000 1.000 95 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPX1(2), PRKCE(5), SOD1(4) 4593551 62 54 62 15 16 3 20 15 8 0 0.234 1.000 1.000 96 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), IGF1(2), IGF1R(11), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(7), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4) 14437897 234 172 164 34 133 6 40 32 23 0 4.38e-05 1.000 1.000 97 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(17), EGFR(7), ERBB3(48), NRG1(18), UBE2D1(2) 6010906 92 79 81 19 41 7 25 11 8 0 0.112 1.000 1.000 98 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(6), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST3GAL5(5), ST6GALNAC4(2), ST8SIA1(3) 3277672 21 19 21 9 7 1 3 7 3 0 0.692 1.000 1.000 99 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(4), FOSL1(3), FOSL2(5), IFNAR1(2), IFNAR2(6), IFNB1(1), MAPK8(5), NFKB1(3), RELA(6), TNFRSF11A(1), TNFSF11(1), TRAF6(1) 6421901 38 34 37 9 19 1 5 1 11 1 0.548 1.000 1.000 100 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(7), SRP19(1), SRP54(3), SRP68(12), SRP72(6), SRP9(1), SRPR(3) 4424152 33 30 33 9 19 1 2 5 6 0 0.547 1.000 1.000 101 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(4), LPO(8), MPO(4), PRDX6(5), TPO(16) 4842840 43 38 43 11 19 2 14 4 4 0 0.192 1.000 1.000 102 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5) 3476319 20 20 20 6 10 1 5 4 0 0 0.479 1.000 1.000 103 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(14), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(3), APOBEC3F(1), APOBEC4(7) 4289239 33 29 33 9 23 2 6 2 0 0 0.359 1.000 1.000 104 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(3), MAPK3(8), NFKB1(3), PIK3CA(94), PIK3R1(7), RB1(73), RELA(6), SP1(10) 11271904 232 176 166 36 105 7 18 21 75 6 0.00294 1.000 1.000 105 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAA2(2), ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), SDS(2) 4887057 29 25 28 9 19 2 0 1 7 0 0.674 1.000 1.000 106 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(3), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(4), IL6(4) 3126878 23 20 23 9 11 1 5 4 2 0 0.680 1.000 1.000 107 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(3), CAT(9), EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16) 6839783 69 56 68 16 36 2 17 6 7 1 0.0516 1.000 1.000 108 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(4), GLUD1(6), OAT(1), PRODH(3) 3204178 20 19 19 7 12 2 3 1 2 0 0.742 1.000 1.000 109 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(3), GRB2(3), HRAS(21), IGF1R(11), IRS1(9), MAP2K1(3), MAPK3(8), PIK3CA(94), PIK3R1(7), RAF1(4), SHC1(8), SOS1(23), YWHAH(2) 11104597 199 151 131 32 113 6 33 27 20 0 0.000627 1.000 1.000 110 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), P2RY1(3), P2RY2(1), P2RY6(2) 3479393 17 15 17 9 5 1 4 6 1 0 0.696 1.000 1.000 111 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(6), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(2) 5836285 37 32 37 7 20 1 6 3 7 0 0.283 1.000 1.000 112 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(2), RANBP2(28), RANGAP1(4) 4925357 35 32 35 8 19 4 5 2 5 0 0.710 1.000 1.000 113 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL16(13), IL1A(1), IL2(1), IL5(1), IL6(4), LTA(1), TNF(4) 5783775 35 31 35 9 22 0 7 2 4 0 0.222 1.000 1.000 114 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(7), BAK1(2), BAX(2), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), FADD(7), FAS(1), FASLG(1), GZMB(2), JUN(4), MAP2K4(4), MAP3K1(10), MAPK10(9), MCL1(2), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), PARP1(14), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFSF10(5), TP53(226), TRADD(2), TRAF2(5) 21671424 399 249 286 64 158 11 107 29 92 2 4.68e-06 1.000 1.000 115 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5), CTH(5), GOT1(2), LDHB(2), LDHC(4), MPST(1) 3992401 19 19 19 9 10 2 4 1 2 0 0.894 1.000 1.000 116 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3) 8771309 81 65 80 17 40 6 12 11 12 0 0.0400 1.000 1.000 117 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3) 8771309 81 65 80 17 40 6 12 11 12 0 0.0400 1.000 1.000 118 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3) 8771309 81 65 80 17 40 6 12 11 12 0 0.0400 1.000 1.000 119 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CRK(4), CXCL12(6), CXCR4(4), GNAI1(4), GNAQ(3), GNB1(7), HRAS(21), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3C2G(11), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), PTK2(15), PTK2B(6), PXN(3), RAF1(4), RELA(6) 15949164 230 158 162 37 132 14 36 27 21 0 5.44e-05 1.000 1.000 120 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(3), CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), IL6(4), IL6R(4), IL6ST(9), JAK1(9), JAK2(8), JAK3(12), JUN(4), MAP2K1(3), MAPK3(8), PTPN11(4), RAF1(4), SHC1(8), SOS1(23), SRF(4), STAT3(6) 13848961 153 115 142 29 72 5 34 18 24 0 0.0138 1.000 1.000 121 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(9), LDLR(10), MBTPS1(13), MBTPS2(7), SCAP(9), SREBF1(6), SREBF2(8) 6841875 62 55 61 17 30 1 14 4 13 0 0.187 1.000 1.000 122 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(1), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(6), PPT1(1) 4925239 29 22 27 9 21 3 1 1 3 0 0.544 1.000 1.000 123 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(6), CREBBP(50), EP300(77), NCOA3(16), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RARA(6), RXRA(25) 12026063 202 144 181 35 68 10 35 21 66 2 0.00676 1.000 1.000 124 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC3(5), RPN1(3), RPN2(5), UBE2A(2), UBE3A(10) 7496769 59 53 58 12 37 1 9 7 5 0 0.138 1.000 1.000 125 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(7), CREBBP(50), EP300(77), FADD(7), HDAC3(1), IKBKB(11), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1) 12947961 193 138 184 33 76 6 28 18 63 2 0.00450 1.000 1.000 126 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TAT(5), TPO(16) 12703476 104 78 103 24 50 3 26 9 15 1 0.0123 1.000 1.000 127 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(11), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF5(9), GSK3B(5), PPP1CA(8) 6762412 68 52 68 13 36 1 15 6 10 0 0.174 1.000 1.000 128 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), FDXR(5), SHMT1(3) 9323680 86 68 85 20 45 6 12 11 12 0 0.0620 1.000 1.000 129 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(1), JAK1(9), JAK2(8), PLA2G2A(2), PTPRU(7), REG1A(8), STAT1(13) 6688362 51 46 50 12 23 0 15 4 9 0 0.228 1.000 1.000 130 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(11), CD44(2), CSF1(4), FCGR3A(3), IL1B(3), IL6R(4), SPN(6), TGFB1(3), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFRSF8(8), TNFSF8(4) 7576664 63 47 60 15 31 0 19 4 9 0 0.0975 1.000 1.000 131 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(9), EPX(6), LPO(8), MPO(4), MTHFR(4), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16) 6743191 58 49 58 16 27 3 17 5 6 0 0.199 1.000 1.000 132 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28) 9755657 77 68 77 17 34 5 16 7 15 0 0.134 1.000 1.000 133 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(6), ADRB2(3), CFTR(18), GNAS(12), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7603732 61 49 61 14 27 3 14 10 7 0 0.172 1.000 1.000 134 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(29), CDH1(15), CREBBP(50), EP300(77), MAP2K1(3), MAP3K7(8), MAPK3(8), SKIL(15), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8) 14971808 224 149 216 31 79 8 32 22 79 4 0.00165 1.000 1.000 135 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(3), IARS(6), IARS2(10), ILVBL(3), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(2), VARS(5), VARS2(12) 10782385 70 59 70 12 37 3 18 3 9 0 0.0409 1.000 1.000 136 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7) 7687900 50 45 50 13 21 2 11 5 11 0 0.222 1.000 1.000 137 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(3), AKT2(5), AKT3(8), BAD(3), BTK(5), CDKN2A(30), DAPP1(2), GRB2(3), GSK3A(2), GSK3B(5), IARS(6), IGFBP1(4), INPP5D(5), PDK1(2), PIK3CA(94), PPP1R13B(7), PTEN(16), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SFN(1), SHC1(8), SOS1(23), SOS2(8), TEC(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 20890972 302 181 233 45 176 13 34 34 43 2 5.13e-05 1.000 1.000 138 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(6), AKT1(3), ASAH1(4), GNAI1(4), GNB1(7), ITGAV(13), ITGB3(9), MAPK3(8), PDGFRA(16), PIK3CA(94), PIK3R1(7), PLCB1(17), PRKCA(3), PTK2(15), RAC1(4), SMPD1(7), SMPD2(2), SPHK1(1), SRC(5) 15998412 225 164 165 40 132 12 34 29 18 0 0.000270 1.000 1.000 139 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(29), AXIN1(4), CREBBP(50), CTNNB1(15), DVL1(5), EP300(77), FZD1(4), GSK3B(5), HDAC1(4), LDB1(3), LEF1(4), PITX2(7), TRRAP(40) 19295421 247 169 233 39 100 10 43 24 68 2 0.000213 1.000 1.000 140 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(3), AKT1(3), AKT2(5), AKT3(8), ARRB1(4), ARRB2(4), ATF2(1), ATF4(3), BDNF(3), BRAF(9), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(18), CACNA1H(12), CACNA1I(8), CACNA1S(12), CACNA2D1(19), CACNA2D2(6), CACNA2D3(8), CACNA2D4(8), CACNB1(5), CACNB2(9), CACNB3(5), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(4), CACNG4(8), CACNG5(7), CACNG6(3), CACNG7(8), CACNG8(3), CASP3(3), CD14(3), CDC25B(2), CDC42(4), CHUK(7), CRK(4), CRKL(1), DAXX(9), DDIT3(1), DUSP1(3), DUSP10(4), DUSP14(4), DUSP16(6), DUSP2(2), DUSP4(3), DUSP5(1), DUSP6(7), DUSP7(4), DUSP8(6), DUSP9(3), ECSIT(4), EGF(17), EGFR(7), ELK1(1), ELK4(6), FAS(1), FASLG(1), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR3(64), FGFR4(6), FLNA(14), FLNB(23), FLNC(18), FOS(4), GADD45A(1), GADD45G(1), GNA12(3), GNG12(2), GRB2(3), HRAS(21), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), JUN(4), JUND(2), KRAS(14), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(8), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK7(3), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MAPT(10), MEF2C(5), MKNK1(6), MKNK2(3), MOS(2), MRAS(2), MYC(2), NF1(39), NFATC2(13), NFATC4(5), NFKB1(3), NFKB2(3), NLK(6), NR4A1(2), NRAS(7), NTF3(1), NTRK1(7), NTRK2(7), PAK1(4), PAK2(9), PDGFB(3), PDGFRA(16), PDGFRB(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PPM1A(6), PPM1B(8), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PPP5C(7), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PTPN5(2), PTPN7(1), PTPRR(8), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(16), RASA1(8), RASA2(6), RASGRF1(12), RASGRF2(9), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KA5(9), RPS6KA6(11), RRAS(2), RRAS2(2), SOS1(23), SOS2(8), SRF(4), STK3(7), STK4(6), TAOK1(11), TAOK2(16), TAOK3(15), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF1A(5), TP53(226), TRAF2(5), TRAF6(1), ZAK(11) 164604592 1657 367 1473 520 730 59 404 179 279 6 0.341 1.000 1.000 141 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(5), AKT3(8), ARHGAP5(12), BAD(3), BCAR1(6), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(2), CAV2(1), CAV3(1), CCND1(4), CCND2(1), CCND3(8), CDC42(4), CHAD(3), COL11A1(30), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), COMP(8), CRK(4), CRKL(1), CTNNB1(15), DIAPH1(5), DOCK1(11), EGF(17), EGFR(7), ELK1(1), ERBB2(54), FARP2(7), FIGF(2), FLNA(14), FLNB(23), FLNC(18), FLT1(8), FN1(21), FYN(7), GRB2(3), GSK3B(5), HGF(12), HRAS(21), IBSP(4), IGF1(2), IGF1R(11), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), JUN(4), KDR(19), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), MAP2K1(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MET(19), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), MYLPF(3), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PARVA(1), PARVB(6), PARVG(3), PDGFB(3), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PDPK1(2), PGF(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PRKCA(3), PRKCG(7), PTEN(16), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(36), RHOA(19), ROCK1(8), ROCK2(15), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SPP1(2), SRC(5), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TLN1(17), TLN2(13), TNC(19), TNN(20), TNR(12), TNXB(38), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCL(4), VEGFA(7), VEGFB(3), VEGFC(6), VTN(3), VWF(21), ZYX(4) 214658828 1888 363 1758 568 922 86 436 202 242 0 0.482 1.000 1.000 142 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(7), ACTN1(7), ACTN2(10), ACTN4(13), APC(29), APC2(6), ARAF(2), ARHGEF1(8), ARHGEF12(14), ARHGEF4(5), ARHGEF6(7), ARHGEF7(9), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), ARPC5(5), BAIAP2(5), BCAR1(6), BDKRB1(4), BDKRB2(3), BRAF(9), CD14(3), CDC42(4), CFL1(1), CFL2(4), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CRK(4), CRKL(1), CSK(7), CYFIP1(8), CYFIP2(9), DIAPH1(5), DIAPH2(22), DIAPH3(7), DOCK1(11), EGF(17), EGFR(7), EZR(12), F2(3), F2R(2), FGD1(6), FGD3(4), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR3(64), FGFR4(6), FN1(21), GIT1(6), GNA12(3), GNA13(12), GNG12(2), GSN(2), HRAS(21), IQGAP1(11), IQGAP2(10), IQGAP3(12), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), KRAS(14), LIMK1(6), LIMK2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MOS(2), MRAS(2), MSN(1), MYH10(24), MYH14(7), MYH9(35), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), MYLPF(3), NCKAP1(12), NCKAP1L(10), NRAS(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDGFB(3), PDGFRA(16), PDGFRB(7), PFN1(4), PFN2(1), PFN3(1), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP1R12B(10), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RDX(4), RHOA(19), ROCK1(8), ROCK2(15), RRAS(2), RRAS2(2), SCIN(1), SLC9A1(7), SOS1(23), SOS2(8), SSH1(8), SSH2(18), SSH3(17), TIAM1(17), TIAM2(18), VAV1(8), VAV2(8), VAV3(7), VCL(4), WAS(4), WASF1(5), WASF2(7), WASL(2) 159672928 1497 358 1348 434 779 60 297 175 185 1 0.0660 1.000 1.000 143 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY7(4), ADCY8(18), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), AGTR1(3), ATP2A1(9), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), ATP2B4(15), AVPR1A(4), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(4), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(18), CACNA1H(12), CACNA1I(8), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CCKAR(3), CCKBR(9), CD38(1), CHRM1(2), CHRM2(5), CHRM3(8), CHRM5(3), CHRNA7(2), CYSLTR2(2), DRD1(2), EDNRA(4), EDNRB(8), EGFR(7), ERBB2(54), ERBB3(48), ERBB4(11), F2R(2), GNA11(3), GNA14(3), GNA15(5), GNAL(4), GNAQ(3), GNAS(12), GRIN1(9), GRIN2A(14), GRIN2C(11), GRIN2D(9), GRM1(22), GRM5(19), GRPR(1), HRH1(9), HRH2(1), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), LHCGR(7), LTB4R2(3), MYLK(15), MYLK2(7), NOS1(15), NOS3(11), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX4(2), P2RX7(5), PDE1A(8), PDE1B(4), PDE1C(15), PDGFRA(16), PDGFRB(7), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PLN(2), PPID(2), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PTAFR(1), PTGER3(5), PTGFR(7), PTK2B(6), RYR1(54), RYR2(83), RYR3(54), SLC25A4(2), SLC25A6(1), SLC8A1(8), SLC8A2(11), SLC8A3(6), SPHK1(1), SPHK2(11), TACR1(3), TACR2(1), TACR3(5), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(9), VDAC1(3), VDAC2(3) 155176749 1353 339 1298 580 629 71 359 134 158 2 0.997 1.000 1.000 144 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(9), ANAPC1(17), ANAPC11(1), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), ATM(65), ATR(32), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNH(4), CDC14A(5), CDC14B(10), CDC16(4), CDC20(4), CDC23(1), CDC25A(5), CDC25B(2), CDC25C(2), CDC27(13), CDC6(9), CDC7(4), CDK2(1), CDK4(6), CDK6(5), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), CDKN2C(2), CDKN2D(1), CHEK1(3), CHEK2(11), CREBBP(50), CUL1(19), DBF4(11), E2F1(3), E2F2(4), E2F3(5), EP300(77), ESPL1(17), FZR1(5), GADD45A(1), GADD45G(1), GSK3B(5), HDAC1(4), HDAC2(3), MAD1L1(4), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), PCNA(4), PKMYT1(2), PLK1(5), PRKDC(35), PTTG1(2), RB1(73), RBL1(9), RBL2(9), RBX1(1), SFN(1), SKP1(7), SKP2(5), SMAD2(5), SMAD3(6), SMAD4(8), SMC1A(16), SMC1B(9), TFDP1(2), TGFB1(3), TGFB3(1), TP53(226), WEE1(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 78745666 1128 338 972 177 445 38 200 102 323 20 1.77e-10 1.000 1.000 145 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(29), APC2(6), AXIN1(4), AXIN2(19), BTRC(4), CACYBP(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CCND1(4), CCND2(1), CCND3(8), CER1(4), CHD8(18), CREBBP(50), CSNK1A1(6), CSNK1A1L(4), CSNK1E(3), CSNK2A1(11), CSNK2B(5), CTBP1(6), CTBP2(10), CTNNB1(15), CTNNBIP1(1), CUL1(19), CXXC4(1), DAAM1(10), DAAM2(9), DKK1(2), DKK2(5), DKK4(2), DVL1(5), DVL2(9), DVL3(4), EP300(77), FBXW11(1), FOSL1(3), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(5), JUN(4), LEF1(4), LRP5(8), LRP6(15), MAP3K7(8), MAPK10(9), MAPK8(5), MAPK9(5), MMP7(1), MYC(2), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NKD1(3), NKD2(1), NLK(6), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PORCN(2), PPARD(6), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRICKLE1(7), PRICKLE2(7), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PSEN1(8), RAC1(4), RAC2(1), RAC3(3), RBX1(1), RHOA(19), ROCK1(8), ROCK2(15), RUVBL1(7), SENP2(1), SFRP1(2), SFRP2(4), SFRP4(5), SIAH1(3), SKP1(7), SMAD2(5), SMAD3(6), SMAD4(8), SOX17(3), TBL1X(5), TBL1XR1(8), TBL1Y(3), TCF7(3), TCF7L2(1), TP53(226), VANGL1(5), VANGL2(3), WIF1(6), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2) 93550978 1107 332 971 287 480 47 251 104 221 4 0.0155 1.000 1.000 146 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(5), AKT3(8), AMOTL1(8), ASH1L(35), CASK(9), CDC42(4), CDK4(6), CGN(10), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTTN(10), EPB41(9), EPB41L1(8), EPB41L2(8), EPB41L3(18), EXOC3(8), EXOC4(13), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), HCLS1(5), HRAS(21), IGSF5(4), INADL(16), JAM2(1), JAM3(4), KRAS(14), LLGL1(4), LLGL2(6), MAGI1(15), MAGI2(17), MAGI3(16), MLLT4(15), MPDZ(20), MPP5(5), MRAS(2), MYH1(16), MYH10(24), MYH11(22), MYH13(21), MYH14(7), MYH15(22), MYH2(22), MYH3(19), MYH4(21), MYH6(14), MYH7(19), MYH7B(20), MYH8(17), MYH9(35), MYL2(4), MYL5(2), MYLPF(3), NRAS(7), OCLN(4), PARD3(23), PARD6A(7), PARD6B(5), PARD6G(1), PPM1J(3), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PPP2R3A(14), PPP2R3B(4), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PTEN(16), RAB13(2), RAB3B(5), RHOA(19), RRAS(2), RRAS2(2), SPTAN1(68), SRC(5), SYMPK(11), TJAP1(2), TJP1(9), TJP2(13), TJP3(4), VAPA(6), YES1(7), ZAK(11) 112809305 1131 328 1093 323 559 62 222 94 192 2 0.170 1.000 1.000 147 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(7), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(5), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(3), CCKBR(9), CGA(2), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CNR1(4), CNR2(6), CRHR1(4), CRHR2(3), CTSG(4), CYSLTR2(2), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2(3), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHB(1), FSHR(5), GABBR1(7), GABBR2(6), GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GABRB1(7), GABRB2(7), GABRB3(10), GABRD(3), GABRE(6), GABRG1(9), GABRG2(5), GABRG3(6), GABRP(3), GABRQ(6), GABRR1(6), GABRR2(2), GALR1(3), GALR2(4), GALR3(3), GH1(3), GH2(4), GHR(6), GHRHR(5), GHSR(8), GIPR(3), GLP1R(3), GLP2R(3), GLRA1(6), GLRA2(4), GLRA3(5), GLRB(3), GNRHR(2), GPR156(7), GPR35(2), GPR50(15), GPR63(3), GPR83(3), GRIA1(16), GRIA2(7), GRIA3(6), GRIA4(23), GRID1(12), GRID2(12), GRIK1(12), GRIK2(15), GRIK3(15), GRIK4(7), GRIK5(14), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), GRIN3A(5), GRIN3B(2), GRM1(22), GRM2(10), GRM3(10), GRM4(9), GRM5(19), GRM6(9), GRM7(12), GRM8(8), GRPR(1), GZMA(4), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HRH4(3), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LEP(1), LEPR(8), LHB(2), LHCGR(7), LTB4R2(3), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MCHR1(3), MCHR2(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPBWR2(4), NPFFR1(2), NPFFR2(6), NPY1R(7), NPY2R(4), NPY5R(5), NR3C1(6), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX4(2), P2RX7(5), P2RY1(3), P2RY10(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(23), PRL(3), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER3(5), PTGER4(5), PTGFR(7), PTGIR(2), PTH2R(8), RXFP1(8), RXFP2(4), SCTR(4), SSTR1(3), SSTR3(4), SSTR4(6), SSTR5(1), TAAR1(3), TAAR5(2), TAAR6(3), TAAR8(4), TACR1(3), TACR2(1), TACR3(5), THRA(2), THRB(1), TRHR(9), TRPV1(3), TSHR(8), UTS2R(1), VIPR1(1), VIPR2(4) 128714603 1105 322 1094 500 454 50 326 144 130 1 0.981 1.000 1.000 148 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(9), ATM(65), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNH(4), CDAN1(6), CDC14A(5), CDC14B(10), CDC20(4), CDC25A(5), CDC25B(2), CDC25C(2), CDC6(9), CDC7(4), CDH1(15), CDK2(1), CDK4(6), CDKN1A(38), CDKN2A(30), CHEK1(3), CHEK2(11), DTX4(3), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), EP300(77), ESPL1(17), GADD45A(1), GSK3B(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), HDAC8(4), MAD1L1(4), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MPEG1(12), MPL(7), PCNA(4), PLK1(5), PRKDC(35), PTPRA(2), PTTG1(2), RB1(73), RBL1(9), SKP2(5), SMAD4(8), TBC1D8(7), TFDP1(2), TGFB1(3), TP53(226), WEE1(10) 63548681 916 320 774 153 346 30 158 83 283 16 9.10e-09 1.000 1.000 149 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(20), ACTG1(11), CHAD(3), COL11A1(30), COL11A2(13), COL17A1(8), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), COMP(8), DES(2), DSC1(9), DSC2(4), DSC3(10), DSG1(12), DSG2(11), DSG3(7), DSG4(9), FN1(21), GJA1(3), GJA10(4), GJA3(3), GJA4(2), GJA5(5), GJA8(4), GJA9(6), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(4), GJD4(4), IBSP(4), INA(2), ITGA6(9), ITGB4(15), KRT1(2), KRT10(6), KRT12(4), KRT13(4), KRT14(3), KRT15(5), KRT16(5), KRT17(1), KRT18(5), KRT19(8), KRT2(4), KRT20(7), KRT23(2), KRT24(7), KRT25(2), KRT27(4), KRT28(4), KRT3(4), KRT31(2), KRT32(3), KRT33A(3), KRT33B(9), KRT34(3), KRT35(3), KRT36(5), KRT37(1), KRT38(6), KRT39(5), KRT4(4), KRT40(4), KRT5(7), KRT6A(6), KRT6B(3), KRT6C(6), KRT7(2), KRT71(6), KRT72(3), KRT73(4), KRT74(2), KRT75(6), KRT76(5), KRT77(4), KRT78(5), KRT79(6), KRT8(6), KRT82(3), KRT83(5), KRT84(10), KRT85(3), KRT9(4), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), LMNA(5), LMNB1(4), LMNB2(7), NES(20), PRPH(4), RELN(36), SPP1(2), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VIM(7), VTN(3), VWF(21) 144100947 1150 320 1128 426 553 52 301 101 142 1 1.000 1.000 1.000 150 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(12), CD36(2), CD44(2), CD47(2), CHAD(3), COL11A1(30), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), DAG1(3), FN1(21), FNDC1(17), FNDC3A(12), GP5(1), GP6(5), GP9(3), HMMR(2), HSPG2(33), IBSP(4), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), RELN(36), SDC1(5), SDC2(3), SDC3(3), SDC4(1), SPP1(2), SV2A(6), SV2B(6), SV2C(6), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VTN(3), VWF(21) 129159742 1018 315 1005 359 476 48 255 99 140 0 0.998 1.000 1.000 151 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(9), ABLIM1(7), ABLIM2(4), ABLIM3(2), ARHGEF12(14), CDC42(4), CDK5(3), CFL1(1), CFL2(4), CXCL12(6), CXCR4(4), DCC(26), DPYSL2(4), DPYSL5(1), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB2(6), EFNB3(4), EPHA1(4), EPHA2(20), EPHA3(20), EPHA4(2), EPHA5(23), EPHA6(14), EPHA7(12), EPHA8(10), EPHB1(14), EPHB2(10), EPHB3(12), EPHB4(7), EPHB6(11), FES(3), FYN(7), GNAI1(4), GNAI2(5), GNAI3(6), GSK3B(5), HRAS(21), ITGB1(3), KRAS(14), L1CAM(8), LIMK1(6), LIMK2(5), LRRC4C(8), MAPK3(8), MET(19), NCK1(2), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NGEF(6), NRAS(7), NRP1(8), NTN1(5), NTN4(4), NTNG1(6), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PLXNA1(8), PLXNA2(17), PLXNA3(7), PLXNB1(13), PLXNB2(23), PLXNB3(10), PLXNC1(9), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PTK2(15), RAC1(4), RAC2(1), RAC3(3), RASA1(8), RGS3(4), RHOA(19), RND1(4), ROBO1(17), ROBO2(22), ROBO3(6), ROCK1(8), ROCK2(15), SEMA3A(11), SEMA3C(9), SEMA3D(18), SEMA3E(13), SEMA3F(6), SEMA3G(8), SEMA4A(9), SEMA4B(6), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA4G(6), SEMA5A(7), SEMA5B(16), SEMA6A(5), SEMA6B(6), SEMA6C(8), SEMA6D(12), SEMA7A(3), SLIT1(9), SLIT2(17), SLIT3(11), SRGAP1(7), SRGAP2(10), SRGAP3(7), UNC5A(5), UNC5B(10), UNC5C(17), UNC5D(10) 113686802 1019 314 992 323 437 50 287 114 129 2 0.423 1.000 1.000 152 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(4), AKT1(3), AKT2(5), AKT3(8), APAF1(7), ATM(65), BAD(3), BAX(2), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CAPN1(5), CAPN2(2), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(5), CYCS(1), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL3RA(6), IRAK1(3), IRAK2(5), IRAK3(9), IRAK4(7), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(6), NTRK1(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), RIPK1(7), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF1A(5), TNFSF10(5), TP53(226), TRADD(2), TRAF2(5) 48377566 715 311 541 136 333 23 146 66 144 3 1.10e-06 1.000 1.000 153 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(65), CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNG2(4), CCNH(4), CDC25A(5), CDK2(1), CDK4(6), CDK7(6), CDKN1A(38), CDKN1B(6), CDKN2A(30), CDKN2B(3), CDKN2C(2), CDKN2D(1), CREB3(5), CREB3L3(8), CREB3L4(7), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), GADD45A(1), GBA2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MNAT1(4), MYC(2), MYT1(10), NACA(14), PCNA(4), POLA2(11), POLE(27), POLE2(4), RB1(73), RBL1(9), RPA2(1), RPA3(4), TFDP1(2), TFDP2(5), TNXB(38), TP53(226), WEE1(10) 44759364 731 308 591 119 266 24 152 51 224 14 1.16e-07 1.000 1.000 154 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(9), ABL2(7), AKT1(3), AKT2(5), AKT3(8), ARAF(2), AREG(2), BAD(3), BRAF(9), BTC(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CBL(8), CBLB(13), CBLC(3), CDKN1A(38), CDKN1B(6), CRK(4), CRKL(1), EGF(17), EGFR(7), EIF4EBP1(1), ELK1(1), ERBB2(54), ERBB3(48), ERBB4(11), EREG(1), GAB1(7), GRB2(3), GSK3B(5), HBEGF(1), HRAS(21), JUN(4), KRAS(14), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MYC(2), NCK1(2), NCK2(5), NRAS(7), NRG1(18), NRG2(3), NRG3(8), NRG4(1), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(7), PTK2(15), RAF1(4), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SRC(5), STAT5A(1), STAT5B(5) 59691762 711 306 583 179 353 36 150 70 96 6 0.0341 1.000 1.000 155 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(3), AKT2(5), AKT3(8), BCL2L1(4), CBL(8), CBLB(13), CBLC(3), CCND1(4), CCND2(1), CCND3(8), CISH(1), CLCF1(3), CNTF(5), CNTFR(1), CREBBP(50), CRLF2(2), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(5), EP300(77), EPO(2), EPOR(5), GH1(3), GH2(4), GHR(6), GRB2(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(9), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL19(2), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), IRF9(6), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), LIF(2), LIFR(9), MPL(7), MYC(2), OSM(5), OSMR(9), PIAS1(3), PIAS2(1), PIAS3(6), PIAS4(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIM1(1), PRL(3), PRLR(4), PTPN11(4), PTPN6(2), SOCS3(1), SOCS4(1), SOCS5(3), SOCS7(5), SOS1(23), SOS2(8), SPRED1(4), SPRED2(6), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(5), STAM(4), STAM2(6), STAT1(13), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(5), STAT6(9), TPO(16), TSLP(3), TYK2(9) 84415300 803 305 729 195 386 28 144 93 148 4 0.00255 1.000 1.000 156 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(28), ACACB(21), AKT1(3), AKT2(5), AKT3(8), ARAF(2), BAD(3), BRAF(9), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CBL(8), CBLB(13), CBLC(3), CRK(4), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(8), FASN(12), FBP1(3), FBP2(2), FLOT1(4), FLOT2(5), FOXO1(2), G6PC(2), G6PC2(2), GCK(1), GRB2(3), GSK3B(5), GYS1(12), GYS2(13), HRAS(21), IKBKB(11), INPP5D(5), INSR(10), IRS1(9), IRS2(5), IRS4(18), KRAS(14), LIPE(14), MAP2K1(3), MAP2K2(5), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MKNK1(6), MKNK2(3), NRAS(7), PCK1(9), PCK2(2), PDE3A(11), PDE3B(9), PDPK1(2), PFKL(2), PFKM(5), PFKP(4), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PKLR(8), PPARGC1A(18), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R3A(18), PPP1R3B(3), PPP1R3C(4), PPP1R3D(3), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACA(2), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(1), PTPN1(5), PTPRF(14), PYGB(8), PYGL(4), PYGM(13), RAF1(4), RAPGEF1(6), RHEB(4), RHOQ(1), RPS6(5), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SLC2A4(4), SOCS3(1), SOCS4(1), SORBS1(10), SOS1(23), SOS2(8), SREBF1(6), TRIP10(6), TSC1(34), TSC2(11) 92696070 891 305 804 275 453 29 182 96 130 1 0.383 1.000 1.000 157 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), ANXA6(6), ARRB1(4), ARRB2(4), ATP1A4(11), ATP1B1(1), ATP1B2(5), ATP1B3(2), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1S(12), CACNB1(5), CACNB3(5), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CASQ1(7), CASQ2(5), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), GJA1(3), GJA4(2), GJA5(5), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GNA11(3), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), ITPR1(21), ITPR2(33), ITPR3(9), KCNB1(8), KCNJ3(4), KCNJ5(2), MIB1(9), NME7(3), PEA15(2), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLN(2), PRKACA(2), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(4), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RYR1(54), RYR2(83), RYR3(54), SFN(1), SLC8A1(8), SLC8A3(6), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3) 108011816 921 297 907 420 422 47 221 97 133 1 1.000 1.000 1.000 158 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(7), ATM(65), ATR(32), BAI1(5), BAX(2), BID(2), CASP3(3), CASP8(14), CASP9(6), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNG1(2), CCNG2(4), CD82(3), CDK2(1), CDK4(6), CDK6(5), CDKN1A(38), CDKN2A(30), CHEK1(3), CHEK2(11), CYCS(1), DDB2(8), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(5), IGF1(2), IGFBP3(1), MDM2(6), MDM4(2), PERP(2), PMAIP1(1), PPM1D(5), PTEN(16), RCHY1(2), RFWD2(6), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(3), SERPINE1(6), SESN1(10), SESN2(2), SESN3(11), SFN(1), SIAH1(3), STEAP3(3), THBS1(8), TNFRSF10B(6), TP53(226), TP53I3(4), TP73(6), TSC2(11), ZMAT3(3) 37787823 650 294 515 111 261 24 141 50 165 9 6.81e-06 1.000 1.000 159 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), ACVR1B(2), ACVR1C(3), BAIAP2(5), CDC42(4), CDH1(15), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTNND1(10), EGFR(7), EP300(77), ERBB2(54), FARP2(7), FER(12), FGFR1(6), FYN(7), IGF1R(11), INSR(10), IQGAP1(11), LEF1(4), LMO7(13), MAP3K7(8), MAPK3(8), MET(19), MLLT4(15), NLK(6), PARD3(23), PTPN1(5), PTPN6(2), PTPRB(17), PTPRF(14), PTPRJ(8), PTPRM(17), PVRL1(10), PVRL2(5), PVRL3(5), PVRL4(4), RAC1(4), RAC2(1), RAC3(3), RHOA(19), SMAD2(5), SMAD3(6), SMAD4(8), SNAI1(4), SNAI2(3), SORBS1(10), SRC(5), SSX2IP(3), TCF7(3), TCF7L2(1), TGFBR1(7), TGFBR2(8), TJP1(9), VCL(4), WAS(4), WASF1(5), WASF2(7), WASF3(5), WASL(2), YES1(7) 69697310 740 293 684 183 341 38 139 79 138 5 0.0256 1.000 1.000 160 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(7), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADM(3), ARRB1(4), ARRB2(4), ATF1(2), ATF2(1), ATF4(3), ATP2A2(10), ATP2A3(5), CACNB3(5), CALCA(1), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CNN1(3), CNN2(4), CORIN(7), CREB3(5), CRHR1(4), DGKZ(3), ETS2(5), FOS(4), GABPA(6), GABPB2(2), GBA2(1), GJA1(3), GNAQ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), GSTO1(2), GUCY1A3(12), IGFBP1(4), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(3), IL6(4), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), MIB1(9), MYL2(4), MYLK2(7), NFKB1(3), NOS1(15), NOS3(11), OXT(1), OXTR(1), PDE4B(7), PDE4D(4), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLCD1(6), PLCG1(12), PLCG2(6), PRKACA(2), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(4), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RLN1(2), RYR1(54), RYR2(83), RYR3(54), SFN(1), SLC8A1(8), SP1(10), TNXB(38), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3) 99781943 853 293 839 356 403 42 198 83 125 2 0.998 1.000 1.000 161 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(5), CADM1(6), CADM3(4), CD2(2), CD22(4), CD226(5), CD274(5), CD276(1), CD28(4), CD34(3), CD4(3), CD40(5), CD40LG(2), CD58(1), CD6(3), CD80(2), CD86(6), CD8A(2), CD99(4), CDH1(15), CDH15(8), CDH2(14), CDH3(7), CDH4(18), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(11), CNTN2(9), CNTNAP1(12), CNTNAP2(25), CTLA4(1), ESAM(1), F11R(5), GLG1(9), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(3), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), ICAM1(7), ICAM2(1), ICAM3(5), ICOS(2), ICOSLG(3), ITGA4(19), ITGA6(9), ITGA8(20), ITGA9(9), ITGAL(17), ITGAM(13), ITGAV(13), ITGB1(3), ITGB2(7), ITGB7(3), ITGB8(11), JAM2(1), JAM3(4), L1CAM(8), MADCAM1(1), MAG(4), MPZ(5), MPZL1(3), NCAM1(9), NCAM2(16), NEGR1(2), NEO1(12), NFASC(11), NLGN1(11), NLGN2(3), NLGN3(6), NRCAM(16), NRXN1(25), NRXN2(11), NRXN3(10), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(19), PTPRF(14), PTPRM(17), PVR(4), PVRL1(10), PVRL2(5), PVRL3(5), SDC1(5), SDC2(3), SDC3(3), SDC4(1), SELE(7), SELP(7), SELPLG(3), SIGLEC1(12), SPN(6), VCAM1(14), VCAN(37) 85441016 787 291 774 264 356 43 176 95 115 2 0.674 1.000 1.000 162 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(7), ACVR1B(2), ACVR2A(3), ACVR2B(2), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(3), BMPR1B(5), BMPR2(9), CCL1(3), CCL13(2), CCL14(2), CCL15(1), CCL16(1), CCL17(1), CCL2(1), CCL21(2), CCL22(2), CCL23(1), CCL25(2), CCL26(1), CCL27(1), CCL28(1), CCL3(2), CCL5(1), CCL7(3), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CCR9(1), CD27(6), CD40(5), CD40LG(2), CD70(1), CLCF1(3), CNTF(5), CNTFR(1), CRLF2(2), CSF1(4), CSF1R(11), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(5), CX3CL1(9), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL12(6), CXCL13(2), CXCL14(2), CXCL16(1), CXCL2(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(3), CXCR4(4), CXCR6(4), EDA(6), EDA2R(1), EDAR(4), EGF(17), EGFR(7), EPO(2), EPOR(5), FAS(1), FASLG(1), FLT1(8), FLT3(10), FLT3LG(1), FLT4(10), GDF5(2), GH1(3), GH2(4), GHR(6), HGF(12), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(9), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17B(3), IL17RA(4), IL17RB(2), IL18R1(4), IL18RAP(9), IL19(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL1RAP(5), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), INHBA(3), INHBB(3), INHBC(1), INHBE(6), KDR(19), KIT(9), KITLG(5), LEP(1), LEPR(8), LIF(2), LIFR(9), LTA(1), LTB(3), LTBR(3), MET(19), MPL(7), NGFR(4), OSM(5), OSMR(9), PDGFB(3), PDGFC(5), PDGFRA(16), PDGFRB(7), PF4V1(2), PLEKHO2(5), PPBP(2), PRL(3), PRLR(4), RELT(1), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(3), TNFRSF14(2), TNFRSF17(2), TNFRSF18(2), TNFRSF19(3), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(8), TNFRSF9(2), TNFSF10(5), TNFSF11(1), TNFSF13(2), TNFSF13B(5), TNFSF14(1), TNFSF18(4), TNFSF4(1), TNFSF8(4), TNFSF9(2), TPO(16), TSLP(3), VEGFA(7), VEGFB(3), VEGFC(6), XCL2(1) 102687070 814 287 809 268 374 30 184 96 128 2 0.465 1.000 1.000 163 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BID(2), BRAF(9), CASP3(3), CD244(6), CD247(1), CD48(1), FAS(1), FASLG(1), FCER1G(1), FCGR3A(3), FCGR3B(8), FYN(7), GRB2(3), GZMB(2), HCST(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-E(5), HLA-G(3), HRAS(21), ICAM1(7), ICAM2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), ITGAL(17), ITGB2(7), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL1(7), KIR3DL2(1), KLRC2(3), KLRC3(3), KLRD1(1), KLRK1(2), KRAS(14), LAT(1), LCK(2), LCP2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MICA(2), MICB(3), NCR1(4), NCR2(4), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NRAS(7), PAK1(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRF1(7), PRKCA(3), PRKCG(7), PTK2B(6), PTPN11(4), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D1A(1), SH2D1B(3), SH3BP2(2), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SYK(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFSF10(5), TYROBP(1), ULBP1(2), ULBP3(2), VAV1(8), VAV2(8), VAV3(7), ZAP70(3) 65745066 649 286 568 190 330 24 138 71 85 1 0.156 1.000 1.000 164 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRB1(3), CSNK1D(3), DRD1(2), DRD2(5), EGF(17), EGFR(7), GJA1(3), GJD2(4), GNA11(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAQ(3), GNAS(12), GRB2(3), GRM1(22), GRM5(19), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), HRAS(21), HTR2A(2), HTR2B(5), HTR2C(1), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(14), MAP2K1(3), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK3(8), MAPK7(3), NPR1(8), NPR2(6), NRAS(7), PDGFB(3), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKG1(10), PRKG2(8), PRKX(1), RAF1(4), SOS1(23), SOS2(8), SRC(5), TJP1(9), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4) 76853148 666 283 637 238 309 30 177 70 80 0 0.722 1.000 1.000 165 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(7), ACTN2(10), ACTN4(13), ARHGAP5(12), BCAR1(6), CD99(4), CDC42(4), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTNND1(10), CXCL12(6), CXCR4(4), CYBA(2), CYBB(1), ESAM(1), EZR(12), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), ITK(6), JAM2(1), JAM3(4), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MLLT4(15), MMP2(7), MMP9(6), MSN(1), MYL2(4), MYL5(2), MYLPF(3), NCF1(1), NCF2(6), NCF4(3), NOX1(4), NOX3(5), OCLN(4), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(7), PTK2(15), PTK2B(6), PTPN11(4), PXN(3), RAC1(4), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(9), RASSF5(2), RHOA(19), RHOH(3), ROCK1(8), ROCK2(15), SIPA1(5), THY1(3), TXK(10), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCAM1(14), VCL(4) 71941691 691 281 619 181 358 32 138 81 82 0 0.00895 1.000 1.000 166 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(7), ACTN2(10), ACTN4(13), DES(2), DMD(41), MYBPC1(17), MYBPC2(8), MYBPC3(5), MYH3(19), MYH6(14), MYH7(19), MYH8(17), MYL2(4), MYOM1(17), NEB(54), TCAP(1), TMOD1(4), TNNC2(1), TNNI1(5), TNNI2(2), TNNI3(1), TNNT1(7), TNNT2(1), TNNT3(1), TPM1(3), TPM2(2), TPM3(1), TPM4(3), TTN(389), VIM(7) 78391260 679 279 674 206 326 30 154 98 65 6 0.894 1.000 1.000 167 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ASIP(1), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CREB3(5), CREB3L2(5), CREB3L3(8), CREB3L4(7), CREBBP(50), CTNNB1(15), DCT(9), DVL1(5), DVL2(9), DVL3(4), EDN1(2), EDNRB(8), EP300(77), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAS(12), GSK3B(5), HRAS(21), KIT(9), KITLG(5), KRAS(14), LEF1(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MC1R(2), MITF(8), NRAS(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), POMC(1), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), RAF1(4), TCF7(3), TCF7L2(1), TYR(12), TYRP1(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2) 63097402 633 276 599 222 265 29 162 68 107 2 0.610 1.000 1.000 168 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADK(3), ADSL(4), ADSS(4), ADSSL1(4), AK1(1), AK2(3), AK5(3), AK7(7), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), CANT1(1), DCK(6), DGUOK(1), ENPP1(7), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), FHIT(4), GART(7), GDA(7), GMPR(2), GMPR2(4), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(9), ITPA(1), NME1(1), NME2(3), NME4(1), NME6(1), NME7(3), NPR1(8), NPR2(6), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT5(3), NUDT9(4), PAICS(4), PAPSS1(4), PAPSS2(2), PDE10A(8), PDE11A(19), PDE1A(8), PDE1C(15), PDE2A(2), PDE3B(9), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE5A(11), PDE6H(1), PDE7A(4), PDE7B(2), PDE8A(4), PDE8B(4), PDE9A(7), PFAS(7), PKLR(8), PNPT1(10), POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PPAT(4), PRIM2(1), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RFC5(5), RRM1(4), RRM2(4), RRM2B(2), XDH(11) 94682952 719 275 707 265 366 37 155 62 97 2 0.971 1.000 1.000 169 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(9), ACTN1(7), ACTR2(3), ACTR3(2), AKT1(3), AKT2(5), AKT3(8), ANGPTL2(3), ARHGEF6(7), ARHGEF7(9), BCAR1(6), BRAF(9), CDC42(4), CDKN2A(30), CRK(4), CSE1L(12), DOCK1(11), EPHB2(10), FYN(7), GRB2(3), GRB7(1), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGB3BP(2), MAP2K4(4), MAP2K7(3), MAP3K11(5), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MRAS(2), MYLK(15), MYLK2(7), P4HB(6), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PIK3CA(94), PIK3CB(11), PKLR(8), PLCG1(12), PLCG2(6), PTEN(16), PTK2(15), RAF1(4), RALA(2), RHO(3), ROCK1(8), ROCK2(15), SHC1(8), SOS1(23), SOS2(8), SRC(5), TERF2IP(4), TLN1(17), TLN2(13), VASP(1), WAS(4), ZYX(4) 70782261 670 272 597 160 349 31 112 86 91 1 0.00422 1.000 1.000 170 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(9), CACNA1A(25), CRHR1(4), GNA11(3), GNA12(3), GNA13(12), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAS(12), GNAZ(3), GRIA1(16), GRIA2(7), GRIA3(6), GRID2(12), GRM1(22), GRM5(19), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), HRAS(21), IGF1(2), IGF1R(11), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(14), LYN(5), MAP2K1(3), MAP2K2(5), MAPK3(8), NOS1(15), NOS3(11), NPR1(8), NPR2(6), NRAS(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PRKCA(3), PRKCG(7), PRKG1(10), PRKG2(8), RAF1(4), RYR1(54) 63815252 596 271 568 211 280 24 158 65 68 1 0.744 1.000 1.000 171 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), AKT2(5), AKT3(8), BCL10(3), CARD11(14), CBL(8), CBLB(13), CBLC(3), CD247(1), CD28(4), CD3E(2), CD3G(2), CD4(3), CD40LG(2), CD8A(2), CDC42(4), CDK4(6), CHUK(7), CTLA4(1), FOS(4), FYN(7), GRAP2(3), GRB2(3), HRAS(21), ICOS(2), IFNG(2), IKBKB(11), IL10(1), IL2(1), IL5(1), ITK(6), JUN(4), KRAS(14), LAT(1), LCK(2), LCP2(5), MALT1(8), MAP3K8(5), NCK1(2), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NRAS(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDCD1(3), PDK1(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKCQ(10), PTPN6(2), PTPRC(19), RASGRP1(6), RHOA(19), SOS1(23), SOS2(8), TEC(10), TNF(4), VAV1(8), VAV2(8), VAV3(7), ZAP70(3) 58939510 633 270 548 149 335 25 127 69 77 0 0.00439 1.000 1.000 172 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(6), ADCY8(18), ARAF(2), ATF4(3), BRAF(9), CACNA1C(14), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CREBBP(50), EP300(77), GNAQ(3), GRIA1(16), GRIA2(7), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), GRM1(22), GRM5(19), HRAS(21), ITPR1(21), ITPR2(33), ITPR3(9), KRAS(14), MAP2K1(3), MAP2K2(5), MAPK3(8), NRAS(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11) 57533505 604 270 573 198 245 32 144 73 108 2 0.543 1.000 1.000 173 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(7), BAD(3), BAK1(2), BAX(2), BCL2L1(4), BCL2L11(3), BID(2), BIRC2(3), BIRC3(3), BIRC5(2), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CHUK(7), CYCS(1), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), GZMB(2), HELLS(5), IKBKB(11), IRF1(1), IRF2(6), IRF3(6), IRF4(3), IRF5(4), IRF6(4), IRF7(3), JUN(4), LTA(1), MAP2K4(4), MAP3K1(10), MAPK10(9), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PLEKHG5(7), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF10B(6), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFSF10(5), TP53(226), TP73(6), TRADD(2), TRAF2(5), TRAF3(2) 33184169 506 269 391 100 213 17 129 36 109 2 0.000159 1.000 1.000 174 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(5), BAK1(2), BAX(2), BFAR(7), BTK(5), CAD(16), CASP10(1), CASP3(3), CASP8(14), CD7(3), CSNK1A1(6), DAXX(9), DEDD(6), DFFA(6), DIABLO(3), EGFR(7), EPHB2(10), FADD(7), FAF1(4), HSPB1(1), IL1A(1), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MET(19), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), NR0B2(2), PFN1(4), PFN2(1), PTPN13(19), RALBP1(2), RIPK1(7), ROCK1(8), SMPD1(7), TNFRSF6B(1), TP53(226), TPX2(7), TRAF2(5), TUFM(3) 41985811 537 266 426 110 223 12 149 42 109 2 0.000630 1.000 1.000 175 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(2), CALML3(1), CALML6(3), CDIPT(3), CDS1(5), CDS2(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(11), ITPK1(4), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), OCRL(4), PI4KA(11), PI4KB(13), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3C3(11), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PRKCA(3), PRKCG(7), PTEN(16), PTPMT1(3), SYNJ1(20), SYNJ2(8) 71982084 641 265 575 203 351 26 119 64 81 0 0.420 1.000 1.000 176 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(2), APOA2(5), CD36(2), CITED2(3), CPT1B(4), CREBBP(50), DUSP1(3), DUT(2), EHHADH(6), EP300(77), FABP1(2), HSD17B4(5), HSPA1A(3), JUN(4), LPL(4), MAPK3(8), ME1(5), MRPL11(2), MYC(2), NCOA1(25), NCOR1(42), NCOR2(19), NFKBIA(6), NR0B2(2), NR1H3(4), NR2F1(3), NRIP1(7), PIK3CA(94), PIK3R1(7), PPARA(1), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PTGS2(6), RB1(73), RELA(6), RXRA(25), SP1(10), SRA1(4), STAT5A(1), STAT5B(5), TNF(4) 36680787 565 263 476 99 245 20 73 54 165 8 4.14e-06 1.000 1.000 177 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), AKT2(5), AKT3(8), BAD(3), BCL2L1(4), CDC42(4), CDK2(1), CDKN1B(6), CDKN2A(30), CREB3(5), CREB5(11), EBP(1), ERBB4(11), F2RL2(2), GAB1(7), GADD45A(1), GRB2(3), GSK3A(2), GSK3B(5), IGF1(2), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), MET(19), MYC(2), NOLC1(3), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PARD3(23), PARD6A(7), PDK1(2), PIK3CA(94), PIK3CD(7), PPP1R13B(7), PREX1(15), PTEN(16), PTK2(15), PTPN1(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SFN(1), SHC1(8), SLC2A4(4), SOS1(23), SOS2(8), TSC1(34), TSC2(11), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 44922071 548 263 471 113 270 19 99 54 103 3 0.000582 1.000 1.000 178 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(20), BAD(3), CABIN1(10), CALM1(2), CALM2(2), CAMK2B(5), CAMK4(4), CD3E(2), CD3G(2), CDKN1A(38), CEBPB(3), CNR1(4), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTLA4(1), EGR2(3), EGR3(3), EP300(77), FCER1A(5), FCGR3A(3), FOS(4), FOSL1(3), GATA3(8), GATA4(1), GSK3A(2), GSK3B(5), HRAS(21), ICOS(2), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL1B(3), IL2(1), IL2RA(1), IL6(4), ITK(6), JUNB(5), KPNA5(5), MAP2K7(3), MAPK14(3), MAPK8(5), MAPK9(5), MEF2A(7), MEF2B(3), MEF2D(3), MYF5(9), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB2(3), NFKBIB(6), NFKBIE(7), NPPB(1), NUP214(17), OPRD1(5), P2RX7(5), PAK1(4), PPIA(1), PPP3CB(7), PPP3CC(4), PPP3R1(1), PTPRC(19), RELA(6), SFN(1), SLA(2), SP1(10), SP3(3), TGFB1(3), TNF(4), TRAF2(5), TRPV6(5), VAV1(8), VAV2(8), VAV3(7), XPO5(10) 52836945 585 261 557 153 234 24 117 50 153 7 0.156 1.000 1.000 179 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(7), ACVR1B(2), ACVR1C(3), ACVR2A(3), ACVR2B(2), ACVRL1(5), AMHR2(2), BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BMPR1A(3), BMPR1B(5), BMPR2(9), CDKN2B(3), CHRD(8), COMP(8), CREBBP(50), CUL1(19), DCN(3), E2F4(2), E2F5(3), EP300(77), FST(4), GDF5(2), GDF6(4), ID1(7), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(3), INHBC(1), INHBE(6), LEFTY2(2), LTBP1(20), MAPK3(8), MYC(2), NODAL(3), NOG(2), PITX2(7), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), RBL1(9), RBL2(9), RBX1(1), RHOA(19), ROCK1(8), ROCK2(15), RPS6KB1(4), RPS6KB2(1), SKP1(7), SMAD1(6), SMAD2(5), SMAD3(6), SMAD4(8), SMAD6(2), SMAD7(3), SMAD9(3), SMURF1(8), SMURF2(8), SP1(10), TFDP1(2), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNF(4), ZFYVE16(14), ZFYVE9(26) 57515988 565 261 544 162 239 25 123 57 117 4 0.575 1.000 1.000 180 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(1), CDC42(4), DLD(7), DUSP10(4), DUSP4(3), DUSP8(6), GAB1(7), GADD45A(1), GCK(1), IL1R1(1), JUN(4), MAP2K4(4), MAP2K5(4), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(5), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK10(9), MAPK7(3), MAPK8(5), MAPK9(5), MYEF2(5), NFATC3(14), NR2C2(7), PAPPA(15), SHC1(8), TP53(226), TRAF6(1), ZAK(11) 29209597 466 260 355 85 178 15 136 36 99 2 0.000337 1.000 1.000 181 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ATF4(3), CACNA1C(14), CACNA1D(18), CACNA1F(11), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDC42(4), CGA(2), EGFR(7), ELK1(1), FSHB(1), GNA11(3), GNAQ(3), GNAS(12), GNRH1(3), GNRHR(2), GRB2(3), HBEGF(1), HRAS(21), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), KRAS(14), LHB(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK7(3), MAPK8(5), MAPK9(5), MMP14(4), MMP2(7), NRAS(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLD1(9), PLD2(3), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCD(8), PRKX(1), PTK2B(6), RAF1(4), SOS1(23), SOS2(8), SRC(5) 73445578 596 259 568 264 272 25 151 65 83 0 1.000 1.000 1.000 182 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), AKAP1(8), AKAP10(6), AKAP11(15), AKAP12(11), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(29), AKAP7(3), AKAP8(3), AKAP9(49), ARHGEF1(8), CALM1(2), CALM2(2), CHMP1B(3), GNA11(3), GNA12(3), GNA13(12), GNA14(3), GNA15(5), GNAI2(5), GNAI3(6), GNAL(4), GNAO1(3), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB5(2), GNG12(2), GNG3(3), GNG4(5), GNG5(1), GNGT2(1), HRAS(21), IL18BP(2), ITPR1(21), KCNJ3(4), KRAS(14), NRAS(7), PALM2(3), PDE1A(8), PDE1B(4), PDE1C(15), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE7A(4), PDE7B(2), PDE8A(4), PDE8B(4), PLCB3(11), PPP3CA(7), PPP3CC(4), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKD3(13), RHOA(19), RRAS(2), SLC9A1(7), USP5(3) 67981034 622 256 584 200 309 31 129 68 84 1 0.652 1.000 1.000 183 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(7), ACVR1B(2), ACVRL1(5), AKT1(3), AURKB(2), BMPR1A(3), BMPR2(9), BUB1(18), CDIPT(3), CDKL1(2), CDKL2(5), CDS1(5), CDS2(3), CLK1(7), CLK2(10), CLK4(3), COL4A3BP(8), CSNK2A1(11), CSNK2B(5), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MAP3K10(2), MOS(2), NEK1(5), NEK3(4), OCRL(4), PAK4(1), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CA(94), PIK3CB(11), PIK3CG(10), PIM2(3), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCG1(12), PLCG2(6), PLK3(10), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKG1(10), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KB1(4), TGFBR1(7), VRK1(3) 65148191 621 256 557 190 328 34 101 76 80 2 0.447 1.000 1.000 184 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), AKT2(5), AKT3(8), BAD(3), CASP9(6), CDC42(4), HRAS(21), KDR(19), KRAS(14), MAP2K1(3), MAP2K2(5), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPKAPK2(1), MAPKAPK3(3), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NOS3(11), NRAS(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKCA(3), PRKCG(7), PTGS2(6), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D2A(6), SHC2(3), SPHK1(1), SPHK2(11), SRC(5), VEGFA(7) 41681082 478 251 401 112 237 22 102 53 64 0 0.00218 1.000 1.000 185 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(8), BCAR1(6), CAPN1(5), CAPN10(2), CAPN11(2), CAPN2(2), CAPN3(7), CAPN5(4), CAPN6(3), CAPN7(4), CAPN9(6), CAV2(1), CAV3(1), CDC42(4), CRK(4), CSK(7), DOCK1(11), FYN(7), GIT2(6), GRB2(3), ILK(3), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAPK10(9), MAPK12(2), MAPK4(5), MAPK6(4), MAPK7(3), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PDPK1(2), PIK3R2(4), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(8), ROCK2(15), SDCCAG8(8), SEPP1(4), SHC1(8), SHC3(1), SORBS1(10), SOS1(23), SRC(5), TLN1(17), TNS1(20), VASP(1), VAV2(8), VAV3(7), VCL(4), ZYX(4) 77266507 605 249 601 205 295 27 130 80 73 0 0.820 1.000 1.000 186 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(9), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CCR9(1), CCRL2(4), CHML(6), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CNR2(6), CX3CR1(4), CXCR3(3), CXCR4(4), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(8), GNB2L1(3), GPR17(3), GPR173(2), GPR174(4), GPR27(1), GPR35(2), GPR37(6), GPR37L1(5), GPR4(4), GPR50(15), GPR6(5), GPR63(3), GPR83(3), GPR85(4), GPR87(3), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LHCGR(7), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(5), OPRK1(4), OPRL1(2), OR10A5(2), OR11A1(4), OR12D3(1), OR1C1(2), OR1F1(2), OR1Q1(2), OR2H1(3), OR5V1(5), OR7A5(6), OR7C1(6), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(2), P2RY12(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), RGR(3), RHO(3), RRH(4), SSTR1(3), SSTR3(4), SSTR4(6), SUCNR1(3), TRHR(9) 70712238 548 246 543 302 225 28 166 71 58 0 0.994 1.000 1.000 187 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), AKT2(5), AKT3(8), CASP8(14), CCL3(2), CCL5(1), CD14(3), CD40(5), CD80(2), CD86(6), CHUK(7), CXCL10(2), CXCL11(1), CXCL9(3), FADD(7), FOS(4), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IKBKB(11), IKBKE(6), IL12A(1), IL12B(3), IL1B(3), IL6(4), IRAK1(3), IRAK4(7), IRF3(6), IRF5(4), IRF7(3), JUN(4), LBP(2), LY96(1), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K7(8), MAP3K8(5), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK9(5), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(6), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), RAC1(4), RELA(6), RIPK1(7), SPP1(2), STAT1(13), TBK1(7), TICAM1(9), TLR1(3), TLR2(3), TLR3(10), TLR4(6), TLR5(11), TLR6(6), TLR7(9), TLR8(9), TLR9(12), TNF(4), TOLLIP(3), TRAF3(2), TRAF6(1) 51991140 513 245 449 132 293 23 79 52 65 1 0.0119 1.000 1.000 188 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), AKT2(5), AKT3(8), BCL10(3), BLNK(8), BTK(5), CARD11(14), CD19(4), CD22(4), CD72(2), CD79A(4), CD79B(2), CD81(2), CHUK(7), CR2(17), FCGR2B(2), FOS(4), GSK3B(5), HRAS(21), IKBKB(11), INPP5D(5), JUN(4), KRAS(14), LILRB3(12), LYN(5), MALT1(8), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NRAS(7), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RASGRP3(5), SYK(8), VAV1(8), VAV2(8), VAV3(7) 43152671 486 245 407 110 241 24 98 54 69 0 0.00171 1.000 1.000 189 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(19), AMY2A(3), AMY2B(9), ASCC3(24), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(5), DHX58(3), ENPP1(7), ENPP3(6), ENTPD7(5), EP400(23), ERCC2(39), ERCC3(7), G6PC(2), G6PC2(2), GAA(5), GANC(7), GBA(4), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), IFIH1(8), LYZL1(1), MGAM(16), MOV10L1(7), NUDT5(3), PGM1(3), PGM3(2), PYGB(8), PYGL(4), PYGM(13), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SI(23), SKIV2L2(9), SMARCA2(24), SMARCA5(4), TREH(5), UGDH(5), UGP2(9), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UXS1(3) 71874261 584 244 560 188 274 34 117 87 72 0 0.841 1.000 1.000 190 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADK(3), ADSL(4), ADSS(4), AK1(1), AK2(3), AK5(3), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), CANT1(1), DCK(6), DGUOK(1), ENPP1(7), ENPP3(6), ENTPD1(1), ENTPD2(2), FHIT(4), GART(7), GDA(7), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(9), ITPA(1), NME1(1), NME2(3), NPR1(8), NPR2(6), NT5C(1), NT5E(6), PAICS(4), PAPSS1(4), PAPSS2(2), PDE1A(8), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE5A(11), PDE6B(5), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(7), PFAS(7), PKLR(8), POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), PPAT(4), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RRM1(4), RRM2(4) 74370900 566 242 557 212 269 31 129 54 81 2 0.960 1.000 1.000 191 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(35), ASH2L(1), CARM1(6), CTCFL(5), DOT1L(21), EED(5), EHMT1(8), EHMT2(12), EZH1(6), EZH2(6), FBXO11(6), HCFC1(4), HSF4(4), JMJD4(4), JMJD6(4), KDM6A(107), MEN1(3), NSD1(23), OGT(5), PAXIP1(8), PPP1CA(8), PPP1CB(4), PPP1CC(2), PRDM2(18), PRDM7(5), PRDM9(13), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), RBBP5(4), SATB1(6), SETD1A(9), SETD2(32), SETD7(3), SETD8(3), SETDB1(14), SETDB2(3), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(1), SUV39H2(1), SUV420H1(20), SUV420H2(2), SUZ12(9), WHSC1(18), WHSC1L1(16) 68945194 499 241 477 133 235 14 63 52 129 6 0.881 1.000 1.000 192 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(13), ABCA10(9), ABCA12(31), ABCA13(45), ABCA2(11), ABCA3(8), ABCA4(15), ABCA5(10), ABCA6(20), ABCA7(11), ABCA8(19), ABCA9(17), ABCB1(16), ABCB10(6), ABCB11(4), ABCB4(11), ABCB5(24), ABCB6(6), ABCB7(5), ABCB8(10), ABCB9(1), ABCC1(10), ABCC10(10), ABCC11(14), ABCC12(14), ABCC2(12), ABCC3(16), ABCC4(11), ABCC5(25), ABCC6(6), ABCC8(10), ABCC9(16), ABCD1(5), ABCD2(9), ABCD3(9), ABCD4(2), ABCG1(5), ABCG2(10), ABCG4(7), ABCG5(4), ABCG8(3), CFTR(18), TAP1(3), TAP2(2) 68236069 513 241 509 166 241 29 99 60 82 2 0.113 1.000 1.000 193 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), AKT2(5), AKT3(8), BTK(5), FCER1A(5), FCER1G(1), FYN(7), GAB2(8), GRB2(3), HRAS(21), IL5(1), INPP5D(5), KRAS(14), LAT(1), LCP2(5), LYN(5), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK9(5), MS4A2(6), NRAS(7), PDK1(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PRKCA(3), PRKCD(8), PRKCE(5), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SOS1(23), SOS2(8), SYK(8), TNF(4), VAV1(8), VAV2(8), VAV3(7) 41767716 451 235 374 123 228 14 98 63 48 0 0.0954 1.000 1.000 194 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), ASAH1(4), ATF1(2), BRAF(9), CAMP(1), CREB3(5), CREB5(11), CREBBP(50), CRKL(1), DAG1(3), EGR1(7), EGR2(3), EGR3(3), EGR4(5), ELK1(1), FRS2(10), GNAQ(3), JUN(4), MAP1B(19), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), NTRK1(7), OPN1LW(5), PIK3C2G(11), PIK3CA(94), PIK3CD(7), PIK3R1(7), PTPN11(4), RPS6KA3(9), SHC1(8), SRC(5), TERF2IP(4), TH(2) 29577944 358 232 294 83 187 16 68 38 48 1 0.0152 1.000 1.000 195 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(11), APAF1(7), ARHGDIB(1), BAG4(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CRADD(1), CYCS(1), DAXX(9), DFFA(6), DFFB(1), FADD(7), GSN(2), LMNA(5), LMNB1(4), LMNB2(7), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK8(5), MDM2(6), NFKB1(3), NFKBIA(6), NUMA1(16), PAK2(9), PRKCD(8), PRKDC(35), PSEN1(8), PSEN2(2), PTK2(15), RASA1(8), RB1(73), RELA(6), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 39982194 438 231 428 116 205 18 55 20 134 6 0.446 1.000 1.000 196 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), AKT2(5), AKT3(8), BRD4(15), CAP1(12), CBL(8), CDC42(4), CDKN2A(30), F2RL2(2), FLOT1(4), FLOT2(5), GRB2(3), GSK3A(2), GSK3B(5), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), LNPEP(7), MAPK3(8), PARD3(23), PARD6A(7), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(7), PTEN(16), PTPN1(5), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SERPINB6(4), SFN(1), SHC1(8), SLC2A4(4), SORBS1(10), SOS1(23), SOS2(8), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 34604802 439 230 367 92 247 16 62 51 60 3 0.00251 1.000 1.000 197 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(5), ALG3(2), ALG6(3), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(5), B3GNT6(1), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT7(1), C1GALT1(4), C1GALT1C1(3), CHPF(4), CHST1(2), CHST11(2), CHST12(3), CHST14(3), CHST2(1), CHST4(3), CHST6(1), CHST7(2), CHSY1(9), DDOST(1), DPAGT1(6), EXT1(10), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), FUT11(2), FUT8(7), GALNT1(5), GALNT10(3), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(8), GALNT3(5), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GANAB(16), GCNT1(5), GCNT3(3), GCNT4(5), HS2ST1(4), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), MGAT5B(7), NDST1(2), NDST2(2), NDST3(7), NDST4(13), OGT(5), RPN1(3), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(8), STT3B(5), UST(4), WBSCR17(9), XYLT1(6), XYLT2(6) 63726999 430 227 425 183 215 22 86 57 49 1 0.994 1.000 1.000 198 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5E(1), INPPL1(11), IPMK(2), ISYNA1(2), ITPK1(4), ITPKA(4), ITPKB(5), MINPP1(5), MIOX(2), OCRL(4), PI4KA(11), PI4KB(13), PIK3C3(11), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PTEN(16), PTPMT1(3), SYNJ1(20), SYNJ2(8) 43092798 408 225 344 113 237 12 75 46 38 0 0.0790 1.000 1.000 199 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(8), CDC40(2), CLK2(10), CLK3(2), CLK4(3), COL2A1(14), CPSF1(9), CPSF2(3), CPSF3(8), CPSF4(3), CSTF1(2), CSTF2(6), CSTF2T(5), CSTF3(4), DDIT3(1), DDX1(8), DDX20(10), DHX15(12), DHX16(9), DHX38(6), DHX8(12), DHX9(21), DICER1(19), DNAJC8(1), FUS(9), GIPC1(2), LSM2(2), LSM7(1), METTL3(22), NCBP1(2), NCBP2(1), NONO(4), NUDT21(1), NXF1(10), PABPN1(4), PAPOLA(10), PHF5A(2), POLR2A(13), PPM1G(10), PRPF18(6), PRPF3(10), PRPF4(5), PRPF4B(8), PRPF8(8), PSKH1(3), PTBP1(2), PTBP2(8), RBM17(11), RBM5(12), RNGTT(4), RNMT(4), RNPS1(2), SF3A1(6), SF3A3(7), SF3B1(24), SF3B2(5), SF3B4(3), SF3B5(2), SNRPA(6), SNRPA1(3), SNRPB(8), SNRPB2(3), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNRPE(2), SNRPG(2), SNRPN(5), SPOP(6), SRPK1(2), SRPK2(6), SRRM1(5), SUPT5H(11), U2AF1(9), U2AF2(4), XRN2(7) 61451614 483 225 467 140 259 29 83 43 68 1 0.895 1.000 1.000 200 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(5), AKT3(8), BAD(3), BCR(3), BLNK(8), BTK(5), CD19(4), CD22(4), CD81(2), CR2(17), CSK(7), DAG1(3), FLOT1(4), FLOT2(5), GRB2(3), GSK3A(2), GSK3B(5), INPP5D(5), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP4K1(8), MAPK3(8), NFATC1(14), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(7), PLCG2(6), PPP1R13B(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PTPRC(19), RAF1(4), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8) 42972563 428 225 367 124 236 22 73 49 48 0 0.172 1.000 1.000 201 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(3), ACTR3(2), AKT1(3), AKT2(5), AKT3(8), ANGPTL2(3), ARHGAP1(1), ARHGAP4(3), ARHGEF11(11), BTK(5), CDC42(4), CFL1(1), CFL2(4), GDI1(3), GDI2(5), INPPL1(11), ITPR1(21), ITPR2(33), ITPR3(9), LIMK1(6), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3CG(10), PIK3R1(7), PITX2(7), PPP1R13B(7), PTEN(16), RACGAP1(6), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), SAG(2), WASF1(5), WASL(2) 40775820 393 222 329 99 224 14 56 50 49 0 0.0351 1.000 1.000 202 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK1G(4), CAMK4(4), CREBBP(50), CSNK1A1(6), EDN1(2), ELSPBP1(3), F2(3), FKBP1A(1), GATA4(1), GSK3B(5), HAND1(4), HAND2(2), HRAS(21), IGF1(2), LIF(2), MAP2K1(3), MAPK14(3), MAPK3(8), MAPK8(5), MEF2C(5), MYH2(22), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NKX2-5(5), NPPA(2), PIK3CA(94), PIK3R1(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAF1(4), RPS6KB1(4), SYT1(6) 29510952 387 220 316 83 181 22 77 42 63 2 0.00271 1.000 1.000 203 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(9), CHUK(7), DAXX(9), ELK1(1), FOS(4), GRB2(3), HRAS(21), IKBKB(11), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(5), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP3K9(11), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(8), MAP4K5(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK4(5), MAPK6(4), MAPK7(3), MAPK8(5), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(6), PAK1(4), PAK2(9), RAC1(4), RAF1(4), RELA(6), RIPK1(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KA5(9), RPS6KB1(4), RPS6KB2(1), SHC1(8), SP1(10), STAT1(13), TGFB1(3), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5) 54792449 472 219 460 159 232 20 89 47 81 3 0.915 1.000 1.000 204 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(7), APH1A(3), CREBBP(50), CTBP1(6), CTBP2(10), DLL1(9), DLL3(4), DLL4(5), DTX1(5), DTX2(6), DTX3(4), DTX3L(9), DTX4(3), DVL1(5), DVL2(9), DVL3(4), EP300(77), HDAC1(4), HDAC2(3), HES1(12), JAG1(13), JAG2(1), LFNG(2), MAML1(3), MAML2(6), MAML3(5), NCOR2(19), NCSTN(10), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), NUMB(3), NUMBL(1), PSEN1(8), PSEN2(2), RBPJ(3), RBPJL(6), RFNG(1), SNW1(11) 39655372 383 216 373 105 152 16 84 35 92 4 0.208 1.000 1.000 205 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(15), BDKRB1(4), BDKRB2(3), C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C3AR1(4), C4BPA(8), C4BPB(3), C5(9), C5AR1(3), C6(9), C7(4), C8A(7), C8B(3), C8G(2), C9(8), CD46(8), CD55(2), CFB(10), CFH(13), CFI(3), CPB2(5), CR1(14), CR2(17), F10(6), F11(10), F12(3), F13A1(8), F13B(9), F2(3), F2R(2), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), KNG1(5), MASP1(12), MASP2(5), MBL2(1), PLAT(6), PLAU(2), PLAUR(7), PLG(4), PROC(2), PROS1(14), SERPINA1(1), SERPINA5(5), SERPINC1(7), SERPIND1(6), SERPINE1(6), SERPING1(3), THBD(4), VWF(21) 52489557 426 215 420 145 190 23 109 51 53 0 0.901 1.000 1.000 206 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), AKT2(5), AKT3(8), BRAF(9), CAB39(3), DDIT4(2), EIF4B(4), EIF4EBP1(1), FIGF(2), HIF1A(6), IGF1(2), MAPK3(8), PDPK1(2), PGF(2), PIK3CA(94), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PRKAA1(9), PRKAA2(7), RHEB(4), RICTOR(19), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), TSC1(34), TSC2(11), ULK1(9), ULK2(9), ULK3(1), VEGFA(7), VEGFB(3), VEGFC(6) 30655982 362 211 298 83 196 14 53 41 57 1 0.0298 1.000 1.000 207 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(21), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADIPOQ(2), ADIPOR1(8), ADIPOR2(1), AGRP(2), AKT1(3), AKT2(5), AKT3(8), CAMKK1(3), CAMKK2(5), CD36(2), CHUK(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), G6PC(2), G6PC2(2), IKBKB(11), IRS1(9), IRS2(5), IRS4(18), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), MAPK10(9), MAPK8(5), MAPK9(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NPY(2), PCK1(9), PCK2(2), POMC(1), PPARA(1), PPARGC1A(18), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3), PRKCQ(10), PTPN11(4), RELA(6), RXRA(25), RXRB(4), RXRG(8), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TYK2(9) 48088678 396 211 380 124 192 21 82 38 63 0 0.353 1.000 1.000 208 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), AKT2(5), AKT3(8), BCR(3), BTK(5), CD19(4), CDKN2A(30), DAPP1(2), FLOT1(4), FLOT2(5), GAB1(7), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(94), PITX2(7), PLCG2(6), PPP1R13B(7), PREX1(15), PTEN(16), PTPRC(19), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SAG(2), SYK(8), TEC(10), VAV1(8) 31925957 373 209 303 84 210 14 54 41 53 1 0.00252 1.000 1.000 209 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(6), CD14(3), CD19(4), CD1A(7), CD1B(3), CD1C(2), CD1D(14), CD1E(13), CD2(2), CD22(4), CD33(6), CD34(3), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(3), CD44(2), CD5(3), CD55(2), CD7(3), CD8A(2), CD9(3), CR1(14), CR2(17), CSF1(4), CSF1R(11), CSF2RA(7), CSF3(1), CSF3R(5), DNTT(11), EPO(2), EPOR(5), FCGR1A(2), FLT3(10), FLT3LG(1), GP5(1), GP9(3), GYPA(5), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL2RA(1), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL7(1), IL7R(7), IL9R(3), ITGA1(7), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGAM(13), ITGB3(9), KIT(9), KITLG(5), MME(13), MS4A1(5), TFRC(9), THPO(6), TNF(4), TPO(16) 47265011 406 208 403 129 161 21 107 57 60 0 0.487 1.000 1.000 210 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(2), CD3E(2), CD3G(2), ELK1(1), FOS(4), FYN(7), GRB2(3), HRAS(21), JUN(4), LAT(1), LCK(2), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKBIA(6), PIK3CA(94), PIK3R1(7), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), PTPN7(1), RAC1(4), RAF1(4), RASA1(8), RELA(6), SHC1(8), SOS1(23), SYT1(6), VAV1(8), ZAP70(3) 27835098 341 203 271 77 186 16 65 35 39 0 0.0281 1.000 1.000 211 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(4), CRKL(1), DOCK1(11), ELK1(1), FOS(4), GAB1(7), GRB2(3), HGF(12), HRAS(21), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP4K1(8), MAPK3(8), MAPK8(5), MET(19), PAK1(4), PIK3CA(94), PIK3R1(7), PTEN(16), PTK2(15), PTK2B(6), PTPN11(4), PXN(3), RAF1(4), RAP1A(1), RAP1B(2), RASA1(8), SOS1(23), SRC(5), STAT3(6) 25525835 328 202 255 51 181 13 53 39 42 0 2.66e-05 1.000 1.000 212 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(5), CALM1(2), CALM2(2), ELK1(1), FCER1A(5), FCER1G(1), FOS(4), GRB2(3), HRAS(21), JUN(4), LYN(5), MAP2K1(3), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PAK2(9), PIK3CA(94), PIK3R1(7), PLA2G4A(1), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8) 25068407 330 201 260 64 177 16 59 40 38 0 0.00243 1.000 1.000 213 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(29), AR(5), ASAH1(4), BRAF(9), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(3), EGFR(7), GNA11(3), GNA15(5), GNAI1(4), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), MAPK10(9), MAPK14(3), PHKA2(8), PIK3CA(94), PIK3CD(7), PIK3R1(7), PITX2(7), PTX3(6), RAF1(4), SRC(5) 30973378 311 197 249 87 182 11 42 41 35 0 0.158 1.000 1.000 214 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(11), EGF(17), EGFR(7), ELK1(1), FOS(4), GRB2(3), HRAS(21), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1) 21866273 290 193 219 51 160 10 53 31 36 0 0.000396 1.000 1.000 215 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(4), ACADL(2), ACADM(1), ACOX1(7), ACOX2(9), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADIPOQ(2), ANGPTL4(6), APOA1(2), APOA2(5), APOA5(4), APOC3(1), AQP7(7), CD36(2), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP27A1(9), CYP4A11(5), CYP4A22(7), CYP7A1(10), CYP8B1(5), DBI(2), EHHADH(6), FABP1(2), FABP2(1), FABP5(1), FABP6(1), FADS2(2), GK(2), GK2(6), HMGCS2(7), ILK(3), LPL(4), ME1(5), MMP1(3), NR1H3(4), PCK1(9), PCK2(2), PDPK1(2), PLTP(7), PPARA(1), PPARD(6), PPARG(13), RXRA(25), RXRB(4), RXRG(8), SCD(2), SCP2(4), SLC27A1(6), SLC27A2(10), SLC27A4(2), SLC27A5(9), SLC27A6(6), SORBS1(10), UBC(9), UCP1(4) 37986717 324 193 302 109 158 17 80 24 45 0 0.545 1.000 1.000 216 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PDGFRA(16), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1) 20366460 282 191 211 49 153 9 52 31 37 0 0.000249 1.000 1.000 217 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CFLAR(2), DAXX(9), DFFA(6), DFFB(1), FADD(7), FAF1(4), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), PTPN13(19), RB1(73), RIPK2(5), SPTAN1(68) 23432912 314 188 303 73 129 9 33 15 121 7 0.401 1.000 1.000 218 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(29), AXIN1(4), CCND1(4), CCND2(1), CCND3(8), CSNK1E(3), CTNNB1(15), DVL1(5), DVL2(9), DVL3(4), FBXW2(5), FOSL1(3), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(5), JUN(4), LDLR(10), MAPK10(9), MAPK9(5), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(6), PPP2R5E(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), RAC1(4), RHOA(19), SFRP4(5), TCF7(3), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1) 34801725 318 188 304 105 173 17 55 26 47 0 0.539 1.000 1.000 219 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(4), CASP2(2), CASP3(3), CASP8(14), CRADD(1), DFFA(6), DFFB(1), FADD(7), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MADD(12), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), RB1(73), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 22382147 310 186 298 63 132 11 27 16 118 6 0.0430 1.000 1.000 220 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(23), CARM1(6), CCND1(4), CREBBP(50), EP300(77), ERCC3(7), ESR1(5), GRIP1(12), GTF2A1(3), GTF2E1(7), GTF2F1(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), MEF2C(5), NCOR2(19), NR0B1(4), NRIP1(7), PELP1(5), POLR2A(13), SRA1(4), TBP(2) 26423386 286 184 275 71 123 11 52 29 69 2 0.129 1.000 1.000 221 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(5), AKT3(8), BAD(3), BCR(3), BLNK(8), BTK(5), CD19(4), CSK(7), DAG1(3), EPHB2(10), GRB2(3), ITPKA(4), ITPKB(5), LYN(5), MAP2K1(3), MAP2K2(5), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PI3(1), PIK3CA(94), PIK3CD(7), PIK3R1(7), PLCG2(6), PPP1R13B(7), RAF1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8) 30626932 308 184 247 73 176 10 53 41 28 0 0.0313 1.000 1.000 222 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(14), ADAM17(7), ATP6AP1(3), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), CASP3(3), CCL5(1), CDC42(4), CHUK(7), CSK(7), CXCL1(1), EGFR(7), F11R(5), GIT1(6), HBEGF(1), IGSF5(4), IKBKB(11), JAM2(1), JAM3(4), JUN(4), LYN(5), MAP2K4(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK8(5), MAPK9(5), MET(19), NFKB1(3), NFKB2(3), NFKBIA(6), NOD1(6), PAK1(4), PLCG1(12), PLCG2(6), PTPN11(4), PTPRZ1(20), RAC1(4), RELA(6), SRC(5), TCIRG1(6), TJP1(9) 40872207 330 182 325 87 174 13 68 27 48 0 0.0956 1.000 1.000 223 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4A1(4), EIF4A2(11), EIF4B(4), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), FKBP1A(1), MKNK1(6), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), PTEN(16), RPS6(5), RPS6KB1(4), TSC1(34), TSC2(11) 16056976 263 181 198 45 132 11 38 26 55 1 0.00503 1.000 1.000 224 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(9), CPEB1(8), EGFR(7), ERBB2(54), ERBB4(11), ETS1(5), ETS2(5), ETV6(12), ETV7(4), FMN2(26), GRB2(3), KRAS(14), MAP2K1(3), MAPK3(8), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), PIWIL1(12), PIWIL2(8), PIWIL3(6), PIWIL4(8), RAF1(4), SOS1(23), SOS2(8), SPIRE1(2), SPIRE2(9) 30169663 303 180 261 84 146 19 69 33 34 2 0.375 1.000 1.000 225 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(3), BCL2L1(4), CBL(8), CFLAR(2), CRKL(1), E2F1(3), FOS(4), GRB2(3), HRAS(21), IL2RA(1), IL2RB(2), IL2RG(5), IRS1(9), JAK1(9), JAK3(12), MAPK3(8), MYC(2), NMI(4), PIK3CA(94), PIK3R1(7), PPIA(1), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(8), SOCS3(1), SOS1(23), STAT5A(1), STAT5B(5), SYK(8) 20983934 262 180 193 67 135 10 48 31 37 1 0.0992 1.000 1.000 226 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(5), ALG6(3), CCKBR(9), CCR3(3), CCR5(6), CELSR1(20), CELSR2(18), CELSR3(29), CHRM2(5), CHRM3(8), CIDEB(2), CXCR3(3), DRD4(1), EDNRA(4), EMR2(6), EMR3(4), F2R(2), FSHR(5), GHRHR(5), GNRHR(2), GPR116(10), GPR132(4), GPR133(12), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(2), GPR61(7), GPR84(2), GPR88(3), GRM1(22), GRPR(1), HRH4(3), LGR6(8), LPHN2(23), LPHN3(21), LTB4R2(3), NTSR1(2), OR2M4(3), P2RY13(3), PTGFR(7), SMO(8), TAAR5(2), TSHR(8), VN1R1(2) 38569589 305 179 298 129 127 14 88 38 37 1 0.658 1.000 1.000 227 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(3), DGKA(9), GCA(1), ITGA9(9), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAPK3(8), NR1I3(4), PAK1(4), PDE3A(11), PDE3B(9), PI3(1), PIK3C2G(11), PIK3CA(94), PIK3CD(7), PIK3R1(7), PSME1(2), RIPK3(6), RPS4X(4), SGCB(1), VASP(1) 28205598 278 179 216 86 163 14 41 29 31 0 0.430 1.000 1.000 228 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(16), CANT1(1), CDA(1), CTPS2(3), DCK(6), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), ITPA(1), NME1(1), NME2(3), NME4(1), NME6(1), NME7(3), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), PNPT1(10), POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PRIM2(1), RFC5(5), RRM1(4), RRM2(4), RRM2B(2), TK1(3), TK2(1), TXNRD1(6), TXNRD2(1), TYMS(3), UCK1(3), UMPS(4), UPB1(4), UPP2(3), UPRT(5) 47018508 327 178 324 128 173 20 53 37 43 1 0.985 1.000 1.000 229 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(11), FOS(4), GRB2(3), HRAS(21), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MPL(7), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), THPO(6) 17521128 259 178 188 43 152 10 38 27 32 0 0.000347 1.000 1.000 230 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF1(1), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), ELAVL1(7), FLT1(8), FLT4(10), HIF1A(6), HRAS(21), KDR(19), NOS3(11), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), PTK2(15), PXN(3), SHC1(8), VHL(2) 19756305 276 178 208 55 155 12 43 29 37 0 0.00202 1.000 1.000 231 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(1), CHN1(3), LIMK1(6), MAP3K1(10), MYL2(4), MYLK(15), NCF2(6), PAK1(4), PDGFRA(16), PIK3CA(94), PIK3R1(7), PLD1(9), PPP1R12B(10), RAC1(4), RALBP1(2), RPS6KB1(4), TRIO(36), VAV1(8), WASF1(5) 20347679 254 177 194 63 149 9 35 28 32 1 0.134 1.000 1.000 232 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(10), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), RHOA(19), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6) 30660327 287 176 274 81 155 12 59 25 35 1 0.339 1.000 1.000 233 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(10), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), RHOA(19), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6) 30660327 287 176 274 81 155 12 59 25 35 1 0.339 1.000 1.000 234 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CA(94), PIK3CB(11), PIK3CG(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCG1(12), PLCG2(6) 25917403 276 176 215 76 163 9 45 31 28 0 0.167 1.000 1.000 235 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(5), AKT3(8), BAD(3), GRB2(3), GSK3A(2), GSK3B(5), IL4R(6), IRS1(9), IRS2(5), JAK1(9), JAK3(12), MAP4K1(8), MAPK3(8), PDK1(2), PIK3CA(94), PIK3CD(7), PIK3R1(7), PPP1R13B(7), RAF1(4), SHC1(8), SOS1(23), SOS2(8), STAT6(9) 21257169 255 175 195 56 146 7 39 36 27 0 0.0186 1.000 1.000 236 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(5), ALPL(4), ALPP(3), ASCC3(24), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(5), DHX58(3), ENTPD7(5), EP400(23), ERCC2(39), ERCC3(7), FPGS(4), GCH1(2), GGH(3), IFIH1(8), MOV10L1(7), NUDT5(3), QDPR(3), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SKIV2L2(9), SMARCA2(24), SMARCA5(4) 36425321 311 172 292 99 152 13 65 49 32 0 0.698 1.000 1.000 237 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(12), DIAPH1(5), FYN(7), GSN(2), HRAS(21), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), MYL2(4), MYLK(15), PFN1(4), PIK3CA(94), PIK3R1(7), PTK2(15), PXN(3), RAF1(4), ROCK1(8), SHC1(8), SRC(5), TLN1(17) 21777703 252 170 185 43 137 9 47 33 26 0 0.000867 1.000 1.000 238 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(6), GRB2(3), HRAS(21), INSR(10), IRS1(9), JAK2(8), MAP2K1(3), MAPK3(8), PIK3CA(94), PIK3R1(7), PLCG1(12), PRKCA(3), PTPN6(2), RAF1(4), RPS6KA1(5), SHC1(8), SLC2A4(4), SOS1(23), SRF(4), STAT5A(1), STAT5B(5) 19321316 243 170 175 58 140 6 43 29 25 0 0.0297 1.000 1.000 239 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), INSR(10), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3CA(94), PIK3R1(7), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SLC2A4(4), SOS1(23), SRF(4) 14807904 235 170 165 42 138 6 38 31 22 0 0.00103 1.000 1.000 240 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(6), AKT1(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), GNAS(12), GRB2(3), HRAS(21), MAPK14(3), MAPK3(8), PIK3CA(94), PIK3R1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAC1(4), RPS6KA1(5), RPS6KA5(9), SOS1(23) 16966243 242 168 174 52 143 6 43 28 22 0 0.0155 1.000 1.000 241 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(4), AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), AFMID(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CARM1(6), CAT(9), CYP1A1(2), CYP1A2(4), CYP1B1(3), DDC(8), ECHS1(1), EHHADH(6), GCDH(6), HAAO(1), HADH(5), HADHA(4), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(1), LCMT1(2), LCMT2(12), LNX1(4), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), NFX1(8), OGDH(21), OGDHL(10), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), TDO2(3), TPH1(3), TPH2(4), WARS(5), WARS2(2), WBSCR22(7) 35180634 249 168 241 77 130 10 43 26 40 0 0.374 1.000 1.000 242 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), GHR(6), IRS1(9), MAPK14(3), MAPK3(8), MKNK1(6), PABPC1(7), PDK2(2), PDPK1(2), PIK3CA(94), PIK3R1(7), PRKCA(3), PTEN(16), RPS6KB1(4) 16448621 242 167 181 48 134 11 35 29 32 1 0.0511 1.000 1.000 243 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CD28(4), CSK(7), CTLA4(1), DAG1(3), EPHB2(10), FBXW7(38), GRAP2(3), GRB2(3), ITK(6), ITPKA(4), ITPKB(5), LAT(1), LCK(2), LCP2(5), NCK1(2), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PLCG1(12), PTPRC(19), RAF1(4), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), SOS1(23), SOS2(8), VAV1(8), ZAP70(3) 32312362 271 166 259 80 132 8 63 29 39 0 0.513 1.000 1.000 244 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(18), ATP4A(5), ATP4B(2), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5E(1), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), COX10(4), COX15(4), COX17(2), COX4I2(1), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(3), COX7B(1), COX7B2(3), COX8A(1), CYC1(7), LHPP(2), NDUFA1(1), NDUFA10(5), NDUFA12(1), NDUFA13(3), NDUFA5(1), NDUFA6(2), NDUFA7(2), NDUFA8(4), NDUFA9(4), NDUFAB1(2), NDUFB10(2), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFB9(3), NDUFS1(5), NDUFS2(3), NDUFS3(4), NDUFS4(3), NDUFS6(1), NDUFS7(3), NDUFS8(1), NDUFV1(4), NDUFV2(6), NDUFV3(4), PPA1(1), PPA2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(4), UQCRFS1(3), UQCRH(2) 32357592 295 165 289 91 148 13 59 32 43 0 0.355 1.000 1.000 245 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(3), CRKL(1), FOS(4), GRB2(3), HRAS(21), JAK2(8), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MYC(2), PIK3CA(94), PIK3R1(7), RAF1(4), SOS1(23), STAT1(13), STAT5A(1), STAT5B(5) 16384918 226 163 155 44 131 7 33 25 30 0 0.0105 1.000 1.000 246 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(10), CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), HDAC5(6), IGF1(2), IGF1R(11), INSR(10), MAP2K6(1), MAPK14(3), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), NFATC1(14), NFATC2(13), PIK3CA(94), PIK3R1(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), SYT1(6), YWHAH(2) 20104042 235 163 176 57 134 14 35 26 26 0 0.0275 1.000 1.000 247 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(2), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), CYP1A1(2), CYP1A2(4), CYP1B1(3), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2F1(4), CYP2S1(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHDH(3), EPHX1(5), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), MGST1(1), MGST2(1), MGST3(1), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2) 33419411 250 162 249 91 120 14 49 30 37 0 0.743 1.000 1.000 248 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(7), ADCY6(15), ADCY8(18), CACNA1A(25), CACNA1B(20), GNAS(12), GNAT3(2), GNB1(7), GNB3(5), GNG3(3), GRM4(9), ITPR3(9), KCNB1(8), PDE1A(8), PLCB2(6), PRKACA(2), PRKACB(4), PRKACG(2), PRKX(1), SCNN1A(12), SCNN1B(6), SCNN1G(5), TAS1R1(2), TAS1R2(7), TAS1R3(20), TAS2R1(1), TAS2R13(2), TAS2R14(1), TAS2R16(4), TAS2R3(3), TAS2R39(3), TAS2R4(1), TAS2R40(2), TAS2R41(3), TAS2R43(1), TAS2R46(3), TAS2R5(1), TAS2R50(3), TAS2R60(5), TAS2R7(1), TAS2R8(1), TAS2R9(6), TRPM5(6) 32728290 262 161 249 119 141 16 60 23 22 0 0.762 1.000 1.000 249 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(5), AKT3(8), CISH(1), GRB2(3), IARS(6), IL13RA1(2), IL2RG(5), IL4R(6), INPP5D(5), JAK1(9), JAK2(8), JAK3(12), NR0B2(2), PI3(1), PIK3CA(94), PPP1R13B(7), RPS6KB1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT6(9), TYK2(9) 21390961 245 161 185 52 146 7 36 33 22 1 0.0108 1.000 1.000 250 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(45), B3GALT4(6), CDR1(4), DGKI(9), FAU(2), IL6ST(9), MRPL19(2), PIGK(4), RPL10(3), RPL11(2), RPL13(3), RPL15(3), RPL17(1), RPL19(2), RPL23(4), RPL24(4), RPL26(1), RPL28(3), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL3L(3), RPL4(5), RPL41(1), RPL5(3), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS12(3), RPS13(2), RPS15(1), RPS16(4), RPS18(6), RPS19(1), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS27A(1), RPS29(1), RPS3(1), RPS3A(1), RPS4X(4), RPS4Y1(1), RPS5(1), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), RPS7(2), RPS8(2), RPS9(3), RPSA(4), SLC36A2(1), TBC1D10C(5), TSPAN9(2), UBA52(7), UBC(9) 30355677 262 160 258 100 129 20 55 26 31 1 0.924 1.000 1.000 251 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(5), AKT3(8), ASAH1(4), BRAF(9), DAG1(3), DRD2(5), EGFR(7), EPHB2(10), GRB2(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PI3(1), PIK3CB(11), PITX2(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), RAF1(4), RGS20(3), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT3(6), TERF2IP(4) 34007869 262 160 257 93 136 9 54 33 30 0 0.791 1.000 1.000 252 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BTRC(4), CSNK1A1(6), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(6), CSNK1G3(3), FBXW11(1), GLI1(10), GLI2(16), GLI3(19), GSK3B(5), HHIP(10), IHH(3), LRP2(46), PRKACA(2), PRKACB(4), PRKACG(2), PRKX(1), PTCH1(19), PTCH2(5), RAB23(2), SHH(6), SMO(8), STK36(13), SUFU(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2), ZIC2(7) 35144072 278 159 275 113 120 13 77 22 46 0 0.980 1.000 1.000 253 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(19), AMY2A(3), AMY2B(9), ENPP1(7), ENPP3(6), G6PC(2), GAA(5), GANAB(16), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), MGAM(16), PGM1(3), PGM3(2), PYGB(8), PYGL(4), PYGM(13), RNPC3(1), SI(23), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UXS1(3) 33041540 262 156 260 96 118 17 58 32 37 0 0.940 1.000 1.000 254 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(29), AXIN1(4), CCND1(4), CD14(3), CTNNB1(15), DVL1(5), FZD1(4), GJA1(3), GNAI1(4), GSK3B(5), IRAK1(3), LBP(2), LEF1(4), LY96(1), MYD88(2), NFKB1(3), PDPK1(2), PIK3CA(94), PIK3R1(7), PPP2CA(2), RELA(6), TLR4(6), TOLLIP(3) 17815899 214 155 150 41 133 6 28 20 27 0 0.0165 1.000 1.000 255 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(7), DAXX(9), EGF(17), EGFR(7), ETS1(5), ETS2(5), FOS(4), HOXA7(5), HRAS(21), IKBKB(11), JUN(4), MAP2K1(3), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), NFKB1(3), NFKBIA(6), PPP2CA(2), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), RAF1(4), RELA(6), RIPK1(7), SP1(10), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRAF2(5) 28517290 253 154 242 94 120 14 58 17 44 0 0.909 1.000 1.000 256 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(3), BDKRB2(3), CALM1(2), CALM2(2), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(10), KDR(19), NOS3(11), PDE2A(2), PDE3A(11), PDE3B(9), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKG1(10), PRKG2(8), RYR2(83), SLC7A1(8), SYT1(6), TNNI1(5) 23210929 230 154 229 92 95 13 56 33 32 1 0.968 1.000 1.000 257 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(12), AR(5), ESR1(5), ESR2(4), ESRRA(2), HNF4A(5), NPM1(1), NR0B1(4), NR1D1(3), NR1D2(10), NR1H2(6), NR1H3(4), NR1I2(5), NR1I3(4), NR2C2(7), NR2E1(1), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(6), NR5A1(1), NR5A2(6), PGR(8), PPARA(1), PPARD(6), PPARG(13), RARA(6), RARB(9), RARG(21), ROR1(6), RORA(6), RORC(7), RXRA(25), RXRB(4), RXRG(8), THRA(2), THRB(1), VDR(2) 24214692 233 153 214 81 123 12 51 20 27 0 0.640 1.000 1.000 258 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(3), GORASP1(2), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK5(3), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PIK3CA(94), PIK3CD(7), PIK3R1(7), SYT1(6), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1) 19379493 221 153 161 47 133 13 33 23 19 0 0.00527 1.000 1.000 259 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(36), EEF1A2(3), EEF1B2(2), EEF1D(2), EEF1G(4), EEF2(5), EEF2K(7), EIF2AK1(5), EIF2AK2(7), EIF2AK3(12), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(17), EIF4G3(27), EIF5(9), EIF5A(5), EIF5B(11), ETF1(2), GSPT2(6), PABPC1(7), PABPC3(8), PAIP1(11), SLC35A4(3) 25401472 250 153 247 55 126 12 47 28 37 0 0.128 1.000 1.000 260 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), CARM1(6), COMT(3), DBH(4), DCT(9), DDC(8), ECH1(8), ESCO1(3), ESCO2(3), FAH(3), GOT1(2), GSTZ1(2), HEMK1(1), HGD(4), HPD(4), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), MIF(1), NAT6(1), PNPLA3(4), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SH3GLB1(1), TAT(5), TH(2), TPO(16), TYR(12), TYRP1(2), WBSCR22(7) 34515087 228 150 224 64 105 6 56 26 35 0 0.191 1.000 1.000 261 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(9), CDC7(4), CDK2(1), CDT1(3), DIAPH2(22), GMNN(1), MCM10(15), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), NACA(14), PCNA(4), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), RFC1(9), RFC2(5), RFC3(1), RFC4(10), RFC5(5), RPA2(1), RPA3(4), RPA4(1), RPS27A(1), UBA52(7), UBC(9) 29496490 222 149 213 63 128 10 35 22 26 1 0.349 1.000 1.000 262 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(5), ARSD(7), ARSE(2), CARM1(6), CYP11B1(6), CYP11B2(13), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(1), HSD17B12(3), HSD17B2(6), HSD17B3(1), HSD17B7(3), HSD17B8(4), HSD3B1(5), HSD3B2(5), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SRD5A1(5), STS(5), SULT1E1(1), SULT2A1(4), SULT2B1(2), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), WBSCR22(7) 29200143 224 149 219 64 111 12 48 31 22 0 0.195 1.000 1.000 263 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(4), AASS(11), ACAT1(5), ACAT2(1), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(23), OGDH(21), OGDHL(10), PIPOX(4), PLOD1(3), PLOD2(5), PLOD3(5), RDH12(2), RDH13(1), SETD1A(9), SETD7(3), SETDB1(14), SHMT1(3), SHMT2(2), SPCS3(1), SUV39H1(1), SUV39H2(1), TMLHE(2) 33573987 232 149 226 114 129 9 41 20 33 0 1.000 1.000 1.000 264 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), CDIPT(3), CDS1(5), CDS2(3), CHAT(5), CHKA(5), CHKB(4), CHPT1(6), CRLS1(1), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(3), ETNK1(4), ETNK2(1), GNPAT(4), GPAM(5), GPD1(6), GPD1L(3), GPD2(10), LCAT(3), LYPLA1(2), LYPLA2(2), NAT6(1), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(7), PTDSS2(1), SH3GLB1(1) 37665706 247 149 246 91 118 15 52 24 38 0 0.893 1.000 1.000 265 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AKR1A1(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CEL(8), DAK(4), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), GK(2), GK2(6), GLA(3), GLB1(5), GPAM(5), LCT(16), LIPA(3), LIPC(6), LIPF(6), LIPG(4), LPL(4), MGLL(3), PNLIP(5), PNLIPRP1(8), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1) 33796651 255 148 253 90 120 14 54 27 40 0 0.619 1.000 1.000 266 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(17), ANAPC11(1), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), BTRC(4), CDC16(4), CDC20(4), CDC23(1), CDC27(13), CUL1(19), CUL2(13), CUL3(9), FBXW11(1), FBXW7(38), FZR1(5), ITCH(12), RBX1(1), SKP1(7), SKP2(5), SMURF1(8), SMURF2(8), TCEB1(1), TCEB2(1), UBA1(1), UBE2C(5), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E1(1), UBE2E2(1), UBE2E3(1), VHL(2), WWP1(5), WWP2(5) 23333351 238 148 220 43 118 7 50 18 44 1 0.0183 1.000 1.000 267 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(3), AGTR2(4), ATP8A1(12), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(9), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CX3CR1(4), CXCR3(3), CXCR4(4), CXCR6(4), EDNRA(4), EDNRB(8), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(8), GNB2L1(3), GNRHR(2), GRPR(1), LHCGR(7), MC1R(2), MC3R(4), MC4R(3), MC5R(3), NMBR(6), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), SSTR1(3), SSTR3(4), SSTR4(6), TAC4(1), TACR1(3), TACR2(1), TACR3(5), TRHR(9), TSHR(8) 30531920 240 148 239 129 98 6 73 35 28 0 0.974 1.000 1.000 268 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CAT(9), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), DDC(8), ECHS1(1), EHHADH(6), GCDH(6), HAAO(1), HADHA(4), KMO(1), KYNU(1), MAOA(4), MAOB(2), SDS(2), TDO2(3), TPH1(3), WARS(5), WARS2(2) 32067281 228 148 225 84 111 10 46 27 34 0 0.687 1.000 1.000 269 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(7), ACSS2(3), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), G6PC2(2), GALM(2), GAPDH(3), GAPDHS(2), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKL(2), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGAM4(4), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1) 33826358 219 147 217 98 99 11 50 23 36 0 0.979 1.000 1.000 270 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(7), CREBBP(50), DUSP1(3), EP300(77), IKBKB(11), IL1B(3), MAP2K3(6), MAP2K6(1), MAP3K7(8), MAPK11(5), MAPK14(3), MYD88(2), NFKB1(3), NFKBIA(6), NR3C1(6), RELA(6), TGFBR1(7), TGFBR2(8), TLR2(3), TNF(4) 17198705 219 146 211 43 82 9 32 19 74 3 0.0338 1.000 1.000 271 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(8), BTK(5), CALM1(2), CALM2(2), CD79A(4), CD79B(2), ELK1(1), FOS(4), GRB2(3), HRAS(21), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK14(3), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8) 22254545 230 145 219 60 103 12 53 25 37 0 0.266 1.000 1.000 272 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(29), AXIN1(4), BTRC(4), CCND1(4), CREBBP(50), CSNK1A1(6), CSNK1D(3), CSNK2A1(11), CTBP1(6), CTNNB1(15), DVL1(5), FZD1(4), GSK3B(5), HDAC1(4), MAP3K7(8), MYC(2), NLK(6), PPARD(6), PPP2CA(2), TLE1(7), WIF1(6) 16992324 187 145 179 48 85 7 33 17 44 1 0.408 1.000 1.000 273 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(65), BMPR1B(5), CCND2(1), CDK4(6), CDKN1B(6), CEBPB(3), DAZL(3), DMC1(2), EGR1(7), ESR2(4), FSHR(5), GJA4(2), INHA(3), LHCGR(7), MLH1(9), NCOR1(42), NR5A1(1), NRIP1(7), PGR(8), PRLR(4), PTGER2(7), SMPD1(7), VDR(2), ZP2(8) 20364106 214 143 211 51 90 8 41 26 48 1 0.186 1.000 1.000 274 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(6), ARHGEF1(8), F2(3), F2R(2), F2RL3(2), GNA12(3), GNA13(12), GNAI1(4), GNAQ(3), GNB1(7), MAP3K7(8), PIK3CA(94), PIK3R1(7), PLCB1(17), PPP1R12B(10), PRKCA(3), PTK2B(6), ROCK1(8) 15005558 203 143 137 40 131 8 22 26 16 0 0.00648 1.000 1.000 275 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(3), APC(29), ASAH1(4), CAMP(1), CAV3(1), DAG1(3), DLG4(6), EPHB2(10), GNAI1(4), GNAQ(3), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PITX2(7), PTX3(6), RAC1(4), RHO(3), RYR1(54) 26624248 213 143 209 76 110 10 40 19 34 0 0.639 1.000 1.000 276 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(7), BAD(3), BAX(2), BCL2A1(1), BCL2L1(4), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CD40(5), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), IKBKE(6), LTA(1), MCL1(2), NFKB1(3), NFKBIA(6), NGFR(4), NR3C1(6), NTRK1(7), PTPN13(19), RIPK1(7), TFG(11), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TRAF3(2), TRAF6(1) 25113586 194 141 189 68 109 7 36 11 31 0 0.919 1.000 1.000 277 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), F10(6), F11(10), F12(3), F2(3), F2R(2), F5(24), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), PROC(2), PROS1(14), SERPINC1(7), SERPING1(3) 25660356 195 141 192 62 101 11 45 19 19 0 0.958 1.000 1.000 278 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(16), CANT1(1), CDA(1), CTPS2(3), DCK(6), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ITPA(1), NME1(1), NME2(3), NT5C(1), NT5E(6), POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), RRM1(4), RRM2(4), TK1(3), TK2(1), TXNRD1(6), TYMS(3), UCK1(3), UMPS(4), UNG(1), UPB1(4) 33291369 231 141 230 95 115 13 37 31 34 1 0.983 1.000 1.000 279 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), ELK1(1), FPR1(3), GNA15(5), GNB1(7), HRAS(21), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(3), MAPK3(8), NCF1(1), NCF2(6), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKBIA(6), PAK1(4), PIK3C2G(11), PLCB1(17), PPP3CA(7), PPP3CB(7), PPP3CC(4), RAC1(4), RAF1(4), RELA(6), SYT1(6) 22140035 218 140 209 63 99 15 49 21 34 0 0.508 1.000 1.000 280 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(3), CDS1(5), CDS2(3), CHAT(5), CHKA(5), CHKB(4), CLC(2), CPT1B(4), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), ETNK1(4), GNPAT(4), GPD1(6), GPD2(10), LCAT(3), LGALS13(3), LYPLA1(2), LYPLA2(2), PAFAH1B1(2), PAFAH2(4), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(3), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB2(6), PLCG1(12), PLCG2(6), PPAP2A(5), PPAP2B(3), PPAP2C(1) 28674293 228 139 227 80 109 10 49 20 40 0 0.565 1.000 1.000 281 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDK5(3), F2(3), FYN(7), GNA11(3), GNAI1(4), GNB1(7), GRB2(3), HRAS(21), JAK2(8), MAP2K1(3), MAP2K2(5), MAPK14(3), MAPK3(8), MAPK8(5), MAPT(10), MYLK(15), PLCG1(12), PRKCA(3), PTK2B(6), RAF1(4), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), SYT1(6) 24219076 220 138 209 84 104 10 49 24 33 0 0.943 1.000 1.000 282 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(3), B3GALT4(6), B3GALT5(3), B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALNT1(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT6(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(10), PIGA(3), PIGB(5), PIGC(4), PIGF(4), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(6), PIGZ(3), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(3), ST8SIA5(2), UGCG(3) 28060482 203 138 200 81 100 4 47 27 25 0 0.692 1.000 1.000 283 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(28), ACACB(21), ACAT1(5), ACAT2(1), ACOT12(6), ACSS1(7), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PCK2(2), PDHA1(5), PDHA2(6), PDHB(2), PKLR(8) 27167995 186 137 183 70 97 6 38 19 26 0 0.844 1.000 1.000 284 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(11), ACTG2(2), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(4), CFL1(1), CFL2(4), FLNA(14), FLNC(18), FSCN1(5), FSCN2(3), FSCN3(3), GDI1(3), GDI2(5), LIMK1(6), MYH2(22), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PFN1(4), PFN2(1), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), VASP(1), WASF1(5), WASL(2) 27858435 212 137 210 70 97 8 54 25 28 0 0.564 1.000 1.000 285 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(5), AKT3(8), ANKRD6(4), APC(29), AXIN1(4), AXIN2(19), CER1(4), CSNK1A1(6), CTNNB1(15), DACT1(6), DKK1(2), DKK2(5), DKK3(5), DKK4(2), DVL1(5), FSTL1(4), GSK3A(2), GSK3B(5), LRP1(36), MVP(11), NKD1(3), NKD2(1), PSEN1(8), PTPRA(2), SENP2(1), SFRP1(2), WIF1(6) 23332724 203 137 198 49 106 6 41 18 31 1 0.0897 1.000 1.000 286 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1) 28427706 199 136 196 80 89 9 48 21 32 0 0.903 1.000 1.000 287 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AKR1A1(2), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), CEL(8), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), GK(2), GLA(3), GLB1(5), LCT(16), LIPC(6), LIPF(6), LIPG(4), LPL(4), PNLIP(5), PNLIPRP1(8), PPAP2A(5), PPAP2B(3), PPAP2C(1) 27691993 226 136 223 77 108 9 48 24 37 0 0.512 1.000 1.000 288 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1) 28427706 199 136 196 80 89 9 48 21 32 0 0.903 1.000 1.000 289 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(5), ALG3(2), ALG5(3), ALG6(3), ALG8(2), ALG9(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DHDDS(7), DOLPP1(1), DPAGT1(6), DPM1(3), FUT8(7), GANAB(16), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), MGAT5B(7), RFT1(4), RPN1(3), RPN2(5), ST6GAL1(4), STT3B(5) 24433056 193 134 192 68 98 9 32 30 24 0 0.699 1.000 1.000 290 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(5), AKT3(8), ARHGEF11(11), CDC42(4), DLG4(6), GNA13(12), LPA(11), MAP2K4(4), MAP3K1(10), MAP3K5(14), MAPK8(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PDK1(2), PHKA2(8), PI3(1), PIK3CB(11), PLD1(9), PLD2(3), PLD3(5), PTK2(15), RDX(4), ROCK1(8), ROCK2(15), SERPINA4(2), SRF(4) 28584013 206 134 199 60 107 14 32 22 31 0 0.601 1.000 1.000 291 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(7), ACTN2(10), BCAR1(6), BCR(3), CAPN1(5), CAPNS2(1), CRKL(1), CSK(7), FYN(7), GRB2(3), HRAS(21), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MAPK8(5), PPP1R12B(10), PTK2(15), PXN(3), RAF1(4), RAP1A(1), ROCK1(8), SHC1(8), SOS1(23), SRC(5), TLN1(17), VCL(4), ZYX(4) 27325846 212 132 201 63 101 10 53 20 28 0 0.466 1.000 1.000 292 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(4), CARS(5), CARS2(7), DARS(3), DARS2(10), EARS2(3), EPRS(12), FARS2(1), FARSA(2), FARSB(6), GARS(6), HARS(6), HARS2(1), IARS(6), IARS2(10), KARS(11), LARS(11), LARS2(3), MARS(3), MARS2(5), MTFMT(2), NARS(4), NARS2(7), PARS2(4), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(6), TARS(9), TARS2(14), VARS(5), VARS2(12), WARS(5), WARS2(2), YARS(5), YARS2(8) 31619530 225 131 222 54 128 15 36 14 32 0 0.0603 1.000 1.000 293 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(4), CANX(6), CD4(3), CD74(2), CD8A(2), CIITA(9), CTSB(6), CTSS(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(3), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), HSP90AA1(27), HSP90AB1(11), HSPA5(11), IFI30(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL1(7), KIR3DL2(1), KLRC2(3), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(1), LTA(1), NFYA(2), NFYB(1), NFYC(1), PDIA3(6), PSME1(2), RFX5(6), RFXANK(1), RFXAP(2), TAP1(3), TAP2(2), TAPBP(4) 26881897 211 130 203 77 100 11 40 20 40 0 0.775 1.000 1.000 294 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(4), DAXX(9), DDIT3(1), ELK1(1), GRB2(3), HMGN1(2), HRAS(21), HSPB1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MYC(2), PLA2G4A(1), RAC1(4), RIPK1(7), RPS6KA5(9), SHC1(8), STAT1(13), TGFB1(3), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5) 21222612 188 130 179 59 91 9 44 12 31 1 0.756 1.000 1.000 295 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(7), APC(29), ATF2(1), AXIN1(4), BMP10(3), BMP2(1), BMP4(1), BMP5(6), BMP7(4), BMPR1A(3), BMPR2(9), CHRD(8), CTNNB1(15), DVL1(5), FZD1(4), GATA4(1), GSK3B(5), MAP3K7(8), MEF2C(5), MYL2(4), NKX2-5(5), NOG(2), NPPA(2), NPPB(1), RFC1(9), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10) 21144259 171 128 165 47 92 7 27 13 31 1 0.542 1.000 1.000 296 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(7), BID(2), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CYCS(1), DFFA(6), DFFB(1), FADD(7), GAS2(3), LMNA(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), SPTAN1(68), TNFRSF10A(5), TNFRSF10B(6), TNFRSF25(3), TNFSF10(5), TRADD(2), TRAF2(5) 19334317 193 128 191 58 111 8 22 7 45 0 0.694 1.000 1.000 297 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLG(8), POLG2(6), POLH(10), POLI(5), POLK(13), POLL(1), POLM(9), POLQ(28), PRIM2(1), REV1(8), REV3L(30), RFC5(5) 23539553 195 128 194 41 99 12 32 22 30 0 0.115 1.000 1.000 298 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(6), F11(10), F12(3), F13B(9), F2(3), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), LPA(11), PLAT(6), PLAU(2), PLG(4), SERPINB2(3), SERPINE1(6), VWF(21) 20485546 170 127 167 48 85 8 39 20 18 0 0.430 1.000 1.000 299 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACADVL(2), ACAT1(5), ACAT2(1), ACOX1(7), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP4A11(5), CYP4A22(7), ECHS1(1), EHHADH(6), GCDH(6), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5) 28516176 175 127 173 64 90 8 31 13 33 0 0.769 1.000 1.000 300 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(8), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), AMDHD1(4), AOC2(5), AOC3(6), ASPA(2), CARM1(6), CNDP1(4), DDC(8), FTCD(4), HAL(7), HARS(6), HARS2(1), HDC(6), HEMK1(1), HNMT(3), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), PRPS1(3), PRPS2(1), UROC1(8), WBSCR22(7) 22963508 178 127 174 52 80 7 41 19 31 0 0.167 1.000 1.000 301 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F1(5), GTF2F2(2), GTF2H1(4), GTF2H3(5), GTF2H4(1), GTF2I(16), GTF2IRD1(9), STON1(13), TAF1(10), TAF10(1), TAF12(2), TAF13(2), TAF1L(21), TAF2(10), TAF4(6), TAF4B(6), TAF5(4), TAF5L(3), TAF6(8), TAF6L(6), TAF7(3), TAF7L(6), TAF9(7), TAF9B(2), TBPL1(2) 21011536 170 126 166 51 83 9 32 19 27 0 0.823 1.000 1.000 302 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(18), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), ATP7A(7), ATP7B(9), COX10(4), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(3), COX7B(1), COX8A(1), NDUFA1(1), NDUFA10(5), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6), PPA2(2), SDHA(9), SDHB(2), SHMT1(3), UQCRB(1), UQCRC1(2), UQCRFS1(3), UQCRH(2) 22214490 198 126 192 53 106 8 39 20 25 0 0.133 1.000 1.000 303 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(5), AZIN1(5), BTG1(3), CBX3(1), CEBPB(3), CLDN5(3), CLOCK(8), CRY1(3), CRY2(4), DAZAP2(5), DNAJA1(4), EIF4G2(10), ETV6(12), GFRA1(4), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(5), NCKAP1(12), NCOA4(6), NR1D2(10), PER1(6), PER2(6), PIGF(4), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(5), SF3A3(7), SUMO3(2), TOB1(5), TUBB3(5), UGP2(9), VAPA(6), ZFR(5) 21198935 193 124 186 58 99 11 33 18 32 0 0.808 1.000 1.000 304 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), AKR1B10(1), ALAS1(12), ALAS2(5), AMT(3), AOC2(5), AOC3(6), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), GNMT(3), HSD3B7(2), MAOA(4), MAOB(2), PEMT(1), PHGDH(3), PIPOX(4), PISD(3), PSAT1(6), PSPH(7), RDH12(2), RDH13(1), SARDH(4), SARS(5), SARS2(6), SDS(2), SHMT1(3), SHMT2(2), TARS(9), TARS2(14) 24615860 172 124 169 66 85 9 31 15 32 0 0.803 1.000 1.000 305 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(3), BLNK(8), ELK1(1), FOS(4), GRB2(3), HRAS(21), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK3(8), MAPK8IP3(11), PAPPA(15), RAC1(4), RPS6KA1(5), RPS6KA3(9), SHC1(8), SOS1(23), SYK(8), VAV1(8), VAV2(8), VAV3(7) 18512847 177 124 166 50 83 3 47 21 23 0 0.372 1.000 1.000 306 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), ELK1(1), GNAS(12), GNB1(7), GRB2(3), HRAS(21), IGF1R(11), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), MKNK1(6), MKNK2(3), MYC(2), NGFR(4), PDGFRA(16), PPP2CA(2), PTPRR(8), RAF1(4), RPS6KA1(5), RPS6KA5(9), SHC1(8), SOS1(23), SRC(5), STAT3(6) 19270645 183 123 173 55 83 7 50 23 20 0 0.506 1.000 1.000 307 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(6), CALM1(2), CALM2(2), ELK1(1), FOS(4), GNAI1(4), GNAQ(3), GNAS(12), GNB1(7), HRAS(21), JUN(4), MAP2K1(3), MAPK3(8), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAF1(4), RPS6KA3(9), SYT1(6) 20306863 197 123 186 51 81 15 50 20 31 0 0.201 1.000 1.000 308 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(1), ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), FUK(9), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), KHK(1), LHPP(2), MPI(7), MTMR1(8), MTMR2(6), MTMR6(8), PFKFB1(5), PFKFB2(3), PFKFB3(8), PFKL(2), PFKM(5), PFKP(4), PGM2(3), PMM1(6), PMM2(2), RDH12(2), RDH13(1), SORD(1), TPI1(1), TSTA3(2) 21450419 165 123 162 67 85 5 32 21 22 0 0.836 1.000 1.000 309 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(4), ACAA2(2), ACADM(1), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOX1(8), AUH(2), BCAT1(4), BCAT2(3), BCKDHA(4), BCKDHB(1), DBT(6), DLD(7), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HADHB(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), OXCT2(2), PCCA(4), PCCB(4) 25068080 173 123 170 54 99 8 20 19 27 0 0.678 1.000 1.000 310 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH4A1(4), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(7), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), GOT1(2), MAOA(4), MAOB(2), NOS1(15), NOS3(11), OAT(1), ODC1(4), OTC(2), P4HA1(8), P4HA3(3), P4HB(6), PYCR1(3), RARS(6), SMS(1) 25549625 173 122 168 57 94 4 30 21 23 1 0.441 1.000 1.000 311 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(3), ATF2(1), CALM1(2), CALM2(2), EGFR(7), ELK1(1), GNAQ(3), GRB2(3), HRAS(21), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PAK1(4), PRKCA(3), PTK2(15), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6) 19422997 181 122 170 49 78 12 41 21 29 0 0.378 1.000 1.000 312 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(1), ARHGAP4(3), ARHGAP5(12), ARHGAP6(10), ARHGEF1(8), ARHGEF11(11), ARHGEF5(6), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), BAIAP2(5), CFL1(1), DIAPH1(5), GSN(2), LIMK1(6), MYL2(4), MYLK(15), OPHN1(8), PFN1(4), PIP5K1A(8), PIP5K1B(3), PPP1R12B(10), ROCK1(8), SRC(5), TLN1(17), VCL(4) 26229374 176 122 174 55 88 6 38 22 22 0 0.614 1.000 1.000 313 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS1(12), ALAS2(5), AMT(3), AOC2(5), AOC3(6), ATP6V0C(3), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CPT1B(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), MAOA(4), MAOB(2), PEMT(1), PISD(3), PLCB2(6), PLCG1(12), PLCG2(6), PSPH(7), SARDH(4), SARS(5), SHMT1(3), SHMT2(2), TARS(9) 24201048 159 120 156 59 78 7 33 12 29 0 0.717 1.000 1.000 314 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(12), ALAS2(5), BLVRA(5), BLVRB(1), COX10(4), COX15(4), CP(5), CPOX(5), EARS2(3), EPRS(12), FECH(3), FTH1(8), FTMT(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), MMAB(2), PPOX(6), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UROD(4), UROS(4) 24518901 173 119 171 57 83 7 25 25 33 0 0.795 1.000 1.000 315 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(28), ACAT1(5), ACAT2(1), ADH5(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(2), PKLR(8) 21467689 155 117 152 57 83 3 32 15 22 0 0.838 1.000 1.000 316 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(11), ACTG2(2), ADCY3(5), ADCY9(8), AK1(1), ARF3(1), ARF4(1), ARF5(2), ARF6(1), ARL4D(1), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), ERO1L(4), GNAS(12), PDIA4(5), PLCG1(12), PLCG2(6), PRKCA(3), SEC61A1(5), SEC61A2(7), TRIM23(5) 21561162 166 116 166 58 86 11 29 19 21 0 0.598 1.000 1.000 317 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(6), ALDOB(3), ALDOC(2), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GAPDHS(2), GCK(1), GOT1(2), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(3), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(2), PDHX(4), PFKL(2), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGK1(2), PKLR(8), TNFAIP1(2), TPI1(1) 24702421 162 115 160 75 79 5 42 16 20 0 0.970 1.000 1.000 318 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(6), ALDH4A1(4), CAD(16), CPS1(13), EARS2(3), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GFPT2(5), GLS(4), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), GMPS(5), GNPNAT1(3), GOT1(2), GPT(2), GPT2(1), GSR(2), GSS(7), NADSYN1(6), NAGK(5), PPAT(4), QARS(6) 22982504 160 115 157 59 81 11 34 16 18 0 0.819 1.000 1.000 319 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(2), ALOX12B(3), ALOX15(5), ALOX15B(3), ALOX5(4), CBR1(2), CBR3(1), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP2U1(2), CYP4A11(5), CYP4A22(7), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GPX6(3), GPX7(4), LTA4H(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3) 22520009 151 115 151 70 64 9 40 16 22 0 0.921 1.000 1.000 320 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(4), ARSD(7), ARSE(2), ASAH1(4), B4GALT6(2), CERK(2), DEGS1(3), ENPP7(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(3), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(7), SMPD2(2), SMPD3(5), SMPD4(9), SPHK1(1), SPHK2(11), SPTLC1(4), SPTLC2(5), UGCG(3), UGT8(6) 20576642 156 115 156 54 69 5 46 18 18 0 0.493 1.000 1.000 321 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM1(2), CALM2(2), CRKL(1), GNAQ(3), GRB2(3), HRAS(21), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP3K1(10), MAPK14(3), MAPK3(8), MAPK8(5), PAK1(4), PLCG1(12), PRKCA(3), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6) 16554880 161 115 150 47 73 7 40 16 25 0 0.511 1.000 1.000 322 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ACSM1(2), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BDH2(3), DDHD1(11), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADH(5), HADHA(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(3), L2HGDH(4), OXCT1(4), OXCT2(2), PDHA1(5), PDHA2(6), PDHB(2), PLA1A(3), PPME1(2), PRDX6(5), RDH12(2), RDH13(1) 23540402 155 114 154 63 83 10 24 19 19 0 0.939 1.000 1.000 323 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(4), AASDH(13), AASS(11), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ATP6V0C(3), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(6), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(5), SDS(2), SHMT1(3), SHMT2(2), TMLHE(2) 21430958 157 114 156 73 84 7 30 15 21 0 0.995 1.000 1.000 324 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(5), AKT3(8), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PDK1(2), PHKA2(8), PIK3CB(11), PITX2(7), PLD1(9), PLD2(3), PLD3(5), VN1R1(2) 26038876 172 114 168 67 93 8 31 15 25 0 0.863 1.000 1.000 325 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(10), CALM1(2), CALM2(2), CAPN2(2), CAPNS2(1), EP300(77), HDAC1(4), HDAC2(3), MEF2D(3), NFATC1(14), NFATC2(13), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), SYT1(6) 14201552 158 113 154 39 59 14 23 20 41 1 0.311 1.000 1.000 326 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(17), EGFR(7), GRB2(3), HRAS(21), MAP2K1(3), MAPK3(8), PTPRB(17), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(5), SRC(5) 14534008 148 112 139 35 69 6 40 15 18 0 0.166 1.000 1.000 327 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BAD(3), BRAF(9), CREB3(5), CREB5(11), DUSP4(3), DUSP6(7), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(3), MAP2K1(3), MAP2K2(5), MAP3K8(5), MAPK3(8), MKNK1(6), MKNK2(3), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), SHC1(8), SOS1(23), SOS2(8), TRAF3(2) 17148106 156 110 154 45 79 5 28 19 25 0 0.614 1.000 1.000 328 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(28), ACACB(21), ACADM(1), ACAT1(5), ACAT2(1), ACSS1(7), ACSS2(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 23121877 144 108 143 49 74 6 22 19 23 0 0.711 1.000 1.000 329 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), PON1(6) 17021974 150 107 145 63 74 10 35 13 18 0 0.724 1.000 1.000 330 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ARG2(3), ASL(7), ASS1(2), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), EPRS(12), GATM(3), GLUD1(6), GLUD2(10), GOT1(2), LAP3(4), NOS1(15), NOS3(11), OAT(1), OTC(2), P4HA1(8), P4HA3(3), PARS2(4), PRODH(3), PYCR1(3), PYCR2(1), PYCRL(3), RARS(6), RARS2(6) 20764080 154 107 147 47 92 7 26 12 16 1 0.417 1.000 1.000 331 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(4), ABAT(4), ACY3(8), ADSL(4), ADSS(4), ADSSL1(4), AGXT(2), AGXT2(2), ASL(7), ASNS(1), ASPA(2), ASRGL1(3), ASS1(2), CAD(16), CRAT(10), DARS(3), DARS2(10), DDO(1), DLAT(6), DLD(7), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(4), NARS2(7), PC(10), PDHA1(5), PDHA2(6), PDHB(2) 21969274 157 106 155 56 87 9 31 12 18 0 0.763 1.000 1.000 332 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), HRAS(21), IL2(1), IL2RA(1), IL2RB(2), IL2RG(5), JAK1(9), JAK3(12), JUN(4), LCK(2), MAP2K1(3), MAPK3(8), MAPK8(5), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5), SYK(8) 13446116 141 106 130 41 56 5 39 18 23 0 0.336 1.000 1.000 333 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(2), CDC42(4), CREB3(5), CREB5(11), DUSP1(3), DUSP10(4), EEF2K(7), EIF4E(2), ELK1(1), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K10(2), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MKNK1(6), MKNK2(3), MYEF2(5), NFKB1(3), NR2C2(7), SRF(4), TRAF6(1) 19295118 146 106 144 48 73 7 32 13 21 0 0.762 1.000 1.000 334 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOX1(8), BCAT1(4), BCKDHA(4), BCKDHB(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), HMGCL(1), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), PCCA(4), PCCB(4), SDS(2) 20998937 140 106 137 55 79 8 16 15 22 0 0.962 1.000 1.000 335 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(2), CDKN1A(38), GNAQ(3), MARCKS(2), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), SP1(10), SP3(3), SYT1(6) 12217340 145 105 137 36 57 11 23 10 39 5 0.560 1.000 1.000 336 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(5), CAPN2(2), CAPNS2(1), CXCR3(3), EGF(17), EGFR(7), HRAS(21), ITGA1(7), ITGB1(3), MAPK3(8), MYL2(4), MYLK(15), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTK2(15), PXN(3), TLN1(17) 18950043 154 105 146 48 63 11 44 12 24 0 0.512 1.000 1.000 337 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(9), CALCRL(8), CD97(5), CRHR1(4), CRHR2(3), ELTD1(10), EMR1(6), EMR2(6), GHRHR(5), GIPR(3), GLP1R(3), GLP2R(3), GPR64(7), LPHN1(9), LPHN2(23), LPHN3(21), SCTR(4), VIPR1(1), VIPR2(4) 15363566 141 104 141 67 52 7 41 15 26 0 0.940 1.000 1.000 338 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(10), ACO1(4), ACO2(5), CLYBL(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), OGDH(21), OGDHL(10), PC(10), PCK1(9), PCK2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 17417733 142 104 138 57 77 4 31 13 17 0 0.836 1.000 1.000 339 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(3), CHUK(7), ELK1(1), FOS(4), IKBKB(11), IRAK1(3), JUN(4), LY96(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(3), MAPK8(5), MYD88(2), NFKB1(3), NFKBIA(6), PPARA(1), RELA(6), TLR10(12), TLR2(3), TLR3(10), TLR4(6), TLR6(6), TLR7(9), TLR9(12), TOLLIP(3), TRAF6(1) 21134052 151 104 149 49 79 8 24 11 29 0 0.700 1.000 1.000 340 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), CFL1(1), GNAQ(3), GNAS(12), GNB1(7), HRAS(21), LIMK1(6), MAP2K1(3), MAPK3(8), MYL2(4), NOX1(4), PIK3C2G(11), PLCB1(17), PPP1R12B(10), PRKCA(3), PTK2(15), RAF1(4), ROCK2(15) 14578472 147 103 137 39 71 8 34 18 16 0 0.453 1.000 1.000 341 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(21), BAIAP2(5), CASP1(9), CASP3(3), CASP7(5), CASP8(14), GAPDH(3), INSR(10), ITCH(12), MAGI1(15), MAGI2(17), RERE(16), WWP1(5), WWP2(5) 13988690 140 103 136 37 80 4 27 13 16 0 0.302 1.000 1.000 342 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(7), GTF2A1(3), GTF2B(2), GTF2E1(7), GTF2F1(5), HDAC3(1), NCOA1(25), NCOA2(12), NCOA3(16), NCOR2(19), POLR2A(13), RARA(6), RXRA(25), TBP(2) 14408276 143 103 127 44 80 5 26 9 23 0 0.664 1.000 1.000 343 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), COMT(3), DBH(4), DCT(9), DDC(8), FAH(3), GOT1(2), GSTZ1(2), HGD(4), HPD(4), MAOA(4), MAOB(2), TAT(5), TH(2), TPO(16), TYR(12) 18344190 141 103 141 43 59 3 40 14 25 0 0.227 1.000 1.000 344 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(7), ACTN2(10), CAPN1(5), CAPNS2(1), ITGA1(7), ITGB1(3), ITGB3(9), PTK2(15), PXN(3), RAC1(4), SPTAN1(68), SRC(5), TLN1(17) 16549937 158 103 157 43 79 7 24 9 39 0 0.284 1.000 1.000 345 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(5), ARSB(8), ARSD(7), ARSE(2), CYP11B1(6), CYP11B2(13), HSD11B2(3), HSD17B2(6), HSD17B3(1), HSD17B8(4), HSD3B1(5), HSD3B2(5), SRD5A1(5), STS(5), SULT1E1(1), SULT2A1(4), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4) 15863593 127 102 127 35 61 8 30 16 12 0 0.163 1.000 1.000 346 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(4), CSF1R(11), DDX20(10), E2F1(3), E2F4(2), ETS1(5), ETS2(5), ETV3(1), FOS(4), HDAC2(3), HDAC5(6), HRAS(21), JUN(4), NCOR2(19), RBL1(9), RBL2(9), SIN3A(12), SIN3B(5) 14959461 133 101 123 36 58 1 36 14 24 0 0.242 1.000 1.000 347 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(3) 13350597 140 100 136 41 50 6 36 14 33 1 0.399 1.000 1.000 348 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(3) 13350597 140 100 136 41 50 6 36 14 33 1 0.399 1.000 1.000 349 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(8), FUCA1(2), FUCA2(6), GALNS(3), GBA(4), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), MAN2B1(9), MAN2B2(7), MAN2C1(8), MANBA(5), NAGLU(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5), SPAM1(2) 19832019 133 100 132 43 71 3 26 19 14 0 0.387 1.000 1.000 350 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAA2(2), ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(1), AKR1C4(5), AKR1D1(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), HSD3B7(2), LIPA(3), RDH12(2), RDH13(1), SLC27A5(9), SOAT1(5), SOAT2(1), SRD5A1(5) 18295273 137 99 131 47 69 8 27 10 23 0 0.428 1.000 1.000 351 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(11), ELK1(1), EPO(2), EPOR(5), FOS(4), GRB2(3), HRAS(21), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PLCG1(12), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5) 12505991 130 98 119 33 63 5 27 13 22 0 0.213 1.000 1.000 352 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(6), CHIA(7), CHIT1(7), CMAS(2), CTBS(2), CYB5R1(4), CYB5R3(4), GFPT1(5), GFPT2(5), GNE(8), GNPDA1(3), GNPDA2(2), GNPNAT1(3), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NAGK(5), NPL(2), PGM3(2), RENBP(4), UAP1(5) 16623480 139 97 138 48 76 7 26 15 15 0 0.752 1.000 1.000 353 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(4), CDK7(6), ERCC3(7), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F2(2), GTF2H1(4), GTF2H4(1), ILK(3), MNAT1(4), POLR1A(18), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3B(6), POLR3D(1), POLR3E(4), POLR3H(2), TAF12(2), TAF13(2), TAF5(4), TAF6(8), TAF7(3), TAF9(7), TBP(2) 20384628 145 97 143 56 87 8 17 12 21 0 0.971 1.000 1.000 354 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(1), B4GALT1(4), B4GALT2(1), G6PC(2), G6PC2(2), GAA(5), GALE(2), GALK1(2), GALT(1), GANC(7), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), LCT(16), MGAM(16), PFKL(2), PFKM(5), PFKP(4), PGM1(3), PGM3(2), RDH12(2), RDH13(1), UGP2(9) 22312520 134 96 131 68 69 5 26 14 20 0 0.989 1.000 1.000 355 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(29), ASAH1(4), CAMP(1), CASP3(3), CERK(2), CREB3(5), CREB5(11), CXCL2(1), DAG1(3), EPHB2(10), FOS(4), GNAQ(3), ITPKA(4), ITPKB(5), JUN(4), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5) 16506815 132 96 129 41 65 4 30 12 21 0 0.644 1.000 1.000 356 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(4), CAD(16), CPS1(13), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GLS(4), GLS2(4), GLUD1(6), GLUL(3), GMPS(5), GOT1(2), GPT(2), GPT2(1), GSS(7), NADSYN1(6), PPAT(4), QARS(6) 19339820 126 95 125 50 63 10 24 13 16 0 0.923 1.000 1.000 357 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), HRH1(9), HRH2(1), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5) 14857312 119 95 116 67 59 5 34 11 10 0 0.847 1.000 1.000 358 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(28), ACADL(2), ACADM(1), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SDS(2), SUCLA2(2), SUCLG1(2), SUCLG2(3) 19322692 127 95 126 45 68 5 19 16 19 0 0.855 1.000 1.000 359 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(2), CHUK(7), EGR2(3), EGR3(3), GNAQ(3), MAP3K1(10), MYC(2), NFATC1(14), NFATC2(13), NFKB1(3), NFKBIA(6), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), SYT1(6), VIPR2(4) 16257616 136 95 136 44 64 12 29 8 23 0 0.658 1.000 1.000 360 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(3), COPS5(1), EDN1(2), EP300(77), EPO(2), HIF1A(6), JUN(4), NOS3(11), P4HB(6), VHL(2) 9849708 123 94 117 29 54 6 11 16 35 1 0.409 1.000 1.000 361 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(3), ARRB2(4), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CLCA1(8), CLCA2(5), CLCA4(12), CNGA3(4), CNGB1(13), GNAL(4), GUCA1B(1), GUCA1C(2), PDE1C(15), PRKACA(2), PRKACB(4), PRKACG(2), PRKG1(10), PRKG2(8), PRKX(1) 17727032 130 94 130 57 67 5 24 14 20 0 0.969 1.000 1.000 362 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SDS(2), SMS(1), UPB1(4) 16930150 121 93 120 47 54 9 25 18 15 0 0.884 1.000 1.000 363 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(16), C5(9), C6(9), C7(4), ICAM1(7), IL1A(1), IL6(4), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELP(7), SELPLG(3), TNF(4), VCAM1(14) 14431991 124 93 124 42 66 7 25 11 15 0 0.668 1.000 1.000 364 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(2), DLG4(6), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), NOS1(15), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), SYT1(6) 14795900 127 93 124 43 49 12 31 17 17 1 0.511 1.000 1.000 365 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), GCK(1), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), KHK(1), MPI(7), PFKFB1(5), PFKFB3(8), PFKM(5), PFKP(4), PMM1(6), PMM2(2), SORD(1), TPI1(1) 13797654 117 92 114 50 59 4 24 14 16 0 0.827 1.000 1.000 366 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(2), ALOX15(5), ALOX5(4), CBR1(2), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(6), GGT1(5), LPO(8), LTA4H(3), MPO(4), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3), TPO(16) 16145160 124 92 123 47 59 5 30 11 18 1 0.564 1.000 1.000 367 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), DAG1(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFAT5(15), PDE6A(4), PDE6B(5), PDE6C(5), PDE6H(1), SLC6A13(2), TF(4) 20732514 130 92 128 64 76 5 23 9 17 0 0.993 1.000 1.000 368 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), F2RL3(2), GNAI1(4), GNB1(7), HRAS(21), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), PLA2G4A(1), PLCB1(17), PRKCA(3), PTGS1(2), PTK2(15), RAF1(4), SRC(5), SYK(8), TBXAS1(3) 14171759 118 91 109 43 48 9 32 13 16 0 0.880 1.000 1.000 369 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(4), B4GALT2(1), FBP2(2), G6PC(2), GAA(5), GALE(2), GALK1(2), GALT(1), GANAB(16), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), LCT(16), MGAM(16), PFKM(5), PFKP(4), PGM1(3), PGM3(2) 18802492 126 90 125 59 64 4 28 12 18 0 0.959 1.000 1.000 370 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ACAA2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), SOAT2(1), SRD5A1(5) 13483670 116 89 111 32 53 8 26 10 19 0 0.154 1.000 1.000 371 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(7), GPRC5A(2), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(22), GRM2(10), GRM3(10), GRM4(9), GRM5(19), GRM7(12), GRM8(8) 12244303 110 89 109 46 46 6 31 13 14 0 0.591 1.000 1.000 372 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(3), DLAT(6), DLD(7), DLST(1), FH(7), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), OGDH(21), PC(10), PDHA1(5), PDHA2(6), PDHB(2), PDHX(4), PDK1(2), PDK2(2), PDK3(1), PDK4(1), PDP2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 16514949 124 89 119 43 67 5 29 10 13 0 0.698 1.000 1.000 373 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(7), APC(29), AXIN1(4), BTRC(4), CTNNB1(15), DLL1(9), DVL1(5), FZD1(4), GSK3B(5), NOTCH1(17), PSEN1(8) 12262160 107 89 103 27 56 3 21 4 21 2 0.437 1.000 1.000 374 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(4), BIRC2(3), BIRC3(3), CASP3(3), CASP8(14), CFLAR(2), FADD(7), JUN(4), MAP2K4(4), MAP3K3(3), MAP3K7(8), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), NR2C2(7), RALBP1(2), RIPK1(7), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 15779448 126 89 121 34 78 5 17 8 18 0 0.277 1.000 1.000 375 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(4), ARSB(8), ARSD(7), ARSE(2), ASAH1(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(7), SMPD2(2), SPTLC1(4), SPTLC2(5), UGCG(3) 13934575 109 88 109 34 52 5 26 14 12 0 0.396 1.000 1.000 376 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(6), CAP1(12), CCNB1(5), CDC25C(2), GNAI1(4), GNAS(12), GNB1(7), HRAS(21), MAPK3(8), MYT1(10), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RPS6KA1(5), SRC(5) 11955968 123 88 114 30 49 6 39 13 16 0 0.111 1.000 1.000 377 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(6), AP2M1(2), BIN1(5), CALM1(2), CALM2(2), DNM1(13), EPN1(1), EPS15(10), NME1(1), NME2(3), PICALM(8), PPP3CA(7), PPP3CB(7), PPP3CC(4), SYNJ1(20), SYNJ2(8), SYT1(6) 12615416 111 88 111 32 60 5 13 14 19 0 0.610 1.000 1.000 378 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), AOC2(5), AOC3(6), ASPA(2), CNDP1(4), DDC(8), HAL(7), HARS(6), HDC(6), HNMT(3), MAOA(4), MAOB(2), PRPS1(3), PRPS2(1) 14173380 101 86 100 33 41 4 28 10 18 0 0.440 1.000 1.000 379 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(7), IFNA1(1), IFNB1(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL1RN(1), IL6(4), IRAK1(3), IRAK2(5), IRAK3(9), JUN(4), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(3), MAPK8(5), MYD88(2), NFKB1(3), NFKBIA(6), RELA(6), TGFB1(3), TGFB3(1), TNF(4), TOLLIP(3), TRAF6(1) 17179234 118 86 116 39 64 3 17 9 25 0 0.727 1.000 1.000 380 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(6), EPHB2(10), F2(3), F2RL1(5), F2RL2(2), F2RL3(2), JUN(4), MAP2K5(4), MAPK7(3), MAPK8(5), MYEF2(5), PLD1(9), PLD2(3), PLD3(5), PTK2(15), RAF1(4), RASAL1(8), SRC(5), TEC(10), VAV1(8) 15908002 121 86 119 43 58 12 21 15 15 0 0.754 1.000 1.000 381 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(17), EGFR(7), MAP2K1(3), MAP3K1(10), MAPK14(3), NCOR2(19), RARA(6), RXRA(25), THRA(2), THRB(1) 9957695 93 85 80 25 43 4 24 5 17 0 0.314 1.000 1.000 382 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(6), CBS(2), CTH(5), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(12), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), METTL2B(3), METTL6(5), PAPSS1(4), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SCLY(2), SEPHS1(2), SEPHS2(1), WBSCR22(7) 14482008 101 85 97 38 55 4 22 9 11 0 0.719 1.000 1.000 383 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(5), DARS(3), EPRS(12), FARS2(1), GARS(6), HARS(6), IARS(6), KARS(11), LARS(11), LARS2(3), MARS(3), MARS2(5), NARS(4), QARS(6), RARS(6), SARS(5), TARS(9), WARS(5), WARS2(2), YARS(5) 18745148 118 83 118 39 70 6 17 8 17 0 0.734 1.000 1.000 384 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(3), AGTR2(4), EDN1(2), EDNRA(4), EDNRB(8), EGF(17), EGFR(7), FOS(4), HRAS(21), JUN(4), MYC(2), NFKB1(3), PLCG1(12), PRKCA(3), RELA(6) 11964577 106 83 96 38 46 8 32 5 15 0 0.743 1.000 1.000 385 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GPX6(3), GPX7(4), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(2) 12766161 105 83 105 47 48 4 26 8 19 0 0.875 1.000 1.000 386 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(5), ALOX5(4), CYP1A2(4), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), HSD3B7(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), RDH12(2), RDH13(1) 13924185 97 83 97 40 44 4 21 12 16 0 0.801 1.000 1.000 387 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(13), APOA1(2), APOA4(4), APOC1(1), APOC2(1), APOC3(1), APOE(2), CETP(2), CYP7A1(10), DGAT1(3), HMGCR(7), LCAT(3), LDLR(10), LIPC(6), LPL(4), LRP1(36), SCARB1(3), SOAT1(5) 15957453 113 83 113 46 57 5 22 10 19 0 0.806 1.000 1.000 388 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(11), EGF(17), EGFR(7), GRB2(3), MET(19), PDGFRA(16), PRKCA(3), SH3GLB1(1), SH3GLB2(1), SH3KBP1(8), SRC(5) 11321290 99 82 98 38 42 5 30 12 10 0 0.888 1.000 1.000 389 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(3), BAX(2), CASP8(14), CYCS(1), FADD(7), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFKB1(3), NSMAF(12), RAF1(4), RELA(6), RIPK1(7), SMPD1(7), TNFRSF1A(5), TRADD(2), TRAF2(5) 11874769 108 82 105 30 60 4 11 11 22 0 0.385 1.000 1.000 390 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ACADM(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SMS(1), SRM(3), UPB1(4) 15706845 106 82 106 39 45 8 22 16 15 0 0.796 1.000 1.000 391 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(7), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DFFB(1), GZMB(2), LMNA(5), LMNB1(4), LMNB2(7), PRF1(7) 11239631 93 81 93 34 53 4 16 7 13 0 0.920 1.000 1.000 392 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), ESCO1(3), ESCO2(3), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MIF(1), MPO(4), NAT6(1), PNPLA3(4), PRDX6(5), SH3GLB1(1), TAT(5), TPO(16) 19882147 105 81 105 27 47 4 30 9 15 0 0.166 1.000 1.000 393 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), C1GALT1(4), C1GALT1C1(3), GALNT1(5), GALNT10(3), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(8), GALNT3(5), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GCNT1(5), GCNT3(3), GCNT4(5), OGT(5), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(8), WBSCR17(9) 18825856 116 81 116 35 55 8 28 11 14 0 0.501 1.000 1.000 394 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(10), ABCC2(12), ABCG2(10), BCHE(9), CES1(4), CES2(7), CYP3A4(9), CYP3A5(4), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3) 13357273 97 81 97 31 47 4 23 11 12 0 0.404 1.000 1.000 395 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(5), BLVRB(1), CP(5), CPOX(5), EPRS(12), FECH(3), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), PPOX(6), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UROD(4), UROS(4) 15967504 103 81 103 39 47 4 18 14 20 0 0.919 1.000 1.000 396 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), HMGCL(1), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(6), PDHB(2), SDHB(2), SDS(2) 15013646 104 80 103 48 54 6 17 13 14 0 0.982 1.000 1.000 397 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(7), FADD(7), IKBKB(11), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(10), MAP3K7(8), MYD88(2), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TLR4(6), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1) 14056195 103 80 101 29 59 3 13 5 23 0 0.495 1.000 1.000 398 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(49), MAP2(16), PPP1CA(8), PPP2CA(2), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5), PRKCE(5) 10617251 99 79 97 19 58 4 13 15 9 0 0.259 1.000 1.000 399 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(4), GRB2(3), HRAS(21), IL3RA(6), JAK2(8), MAP2K1(3), MAPK3(8), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5) 10322024 101 79 92 28 42 3 23 10 23 0 0.393 1.000 1.000 400 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(3), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(6), ILVBL(3), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCDC(1), PPCS(9), UPB1(4), VNN1(3) 10082732 95 78 91 41 43 5 20 17 10 0 0.968 1.000 1.000 401 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(2), MRPS7(5), RPL10A(3), RPL10L(3), RPL11(2), RPL13(3), RPL19(2), RPL22L1(2), RPL23A(4), RPL24(4), RPL26(1), RPL28(3), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL3L(3), RPL41(1), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPS12(3), RPS13(2), RPS16(4), RPS18(6), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1), RPS5(1), RPS6(5), RPS7(2), RPS8(2), RPS9(3), RPSA(4) 13137032 108 78 107 40 55 9 26 5 13 0 0.552 1.000 1.000 402 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(2), CHUK(7), CRADD(1), IKBKB(11), JUN(4), LTA(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP4K2(5), MAPK14(3), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 13892378 103 78 100 34 66 4 11 4 18 0 0.648 1.000 1.000 403 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(14), CR2(17), FCGR2B(2), HLA-DRA(4), HLA-DRB1(1), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19) 8820248 90 77 89 30 38 5 23 10 14 0 0.597 1.000 1.000 404 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2) 8041527 99 77 96 22 43 6 14 13 22 1 0.405 1.000 1.000 405 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(12), ARHGEF1(8), GNA12(3), GNA13(12), GNAQ(3), GNB1(7), MYL2(4), MYLK(15), PLCB1(17), PPP1R12B(10), PRKCA(3), ROCK1(8) 12072772 102 77 95 31 57 3 19 15 8 0 0.701 1.000 1.000 406 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UGDH(5), UGP2(9), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), XYLB(8) 15913885 102 76 98 29 49 7 13 16 17 0 0.484 1.000 1.000 407 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), P4HB(6), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(6) 14352855 85 76 84 40 40 6 22 6 11 0 0.999 1.000 1.000 408 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(10), BCAR1(6), CSK(7), CTNNA1(6), CTNNA2(22), CTNNB1(15), PTK2(15), PXN(3), SRC(5), VCL(4) 11096019 100 75 96 23 47 8 24 11 10 0 0.112 1.000 1.000 409 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(6), F2(3), F2R(2), F5(24), F7(8), FGA(17), FGB(5), FGG(7), PROC(2), PROS1(14), SERPINC1(7) 9579714 95 75 93 22 54 4 18 9 10 0 0.208 1.000 1.000 410 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), ADC(6), AGMAT(1), ALDH18A1(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(7), ASS1(2), CPS1(13), GATM(3), MAOA(4), MAOB(2), NAGS(1), ODC1(4), OTC(2), SAT2(3), SMS(1), SRM(3) 17041271 98 75 95 28 48 3 18 14 15 0 0.202 1.000 1.000 411 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2B1(9), MAN2B2(7), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5) 11757472 85 75 84 28 44 1 20 10 10 0 0.492 1.000 1.000 412 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(6), AP2M1(2), BAD(3), BTK(5), EEA1(13), GRASP(3), GSK3A(2), GSK3B(5), LYN(5), PDPK1(2), PFKL(2), PFKM(5), PFKP(4), PLCG1(12), PRKCE(5), PRKCZ(4), RAB5A(2), RAC1(4), RPS6KB1(4), VAV2(8) 14514204 99 75 99 32 57 5 10 13 13 1 0.471 1.000 1.000 413 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(6), APEX1(1), CREBBP(50), DFFA(6), DFFB(1), GZMA(4), GZMB(2), HMGB2(6), NME1(1), PRF1(7), SET(3) 6128157 87 75 84 24 28 2 20 9 27 1 0.481 1.000 1.000 414 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(5), CSNK1D(3), DRD1(2), DRD2(5), GRM1(22), PLCB1(17), PPP1CA(8), PPP1R1B(5), PPP2CA(2), PPP3CA(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 9327568 101 74 101 26 50 3 24 12 12 0 0.128 1.000 1.000 415 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(6), ALDOB(3), ALDOC(2), DERA(3), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKL(2), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1), TKTL1(7), TKTL2(5) 14132949 90 74 90 50 37 4 27 12 10 0 0.994 1.000 1.000 416 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), PON1(6), PON2(2), PON3(3) 10449981 96 73 92 40 42 4 28 7 15 0 0.841 1.000 1.000 417 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DPAGT1(6), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(9), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), RPN1(3), RPN2(5), ST6GAL1(4) 11514005 89 73 89 34 42 4 19 15 9 0 0.747 1.000 1.000 418 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), PC(10), PCK1(9), SDHA(9), SDHB(2), SUCLA2(2), SUCLG1(2), SUCLG2(3) 12013419 88 72 87 29 50 2 20 6 10 0 0.529 1.000 1.000 419 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(6), GPLD1(5), PGAP1(5), PIGA(3), PIGB(5), PIGC(4), PIGF(4), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(6), PIGW(5), PIGZ(3) 13765901 94 72 93 33 46 2 26 5 15 0 0.393 1.000 1.000 420 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AGPS(5), CHPT1(6), ENPP2(7), ENPP6(3), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(4), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PPAP2A(5), PPAP2B(3), PPAP2C(1) 13463168 89 72 89 45 47 2 11 11 18 0 0.994 1.000 1.000 421 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(3), ATG7(4), BECN1(2), GABARAP(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNG(2), PIK3C3(11), PIK3R4(11), PRKAA1(9), PRKAA2(7), ULK1(9), ULK2(9), ULK3(1) 12161636 90 72 89 26 54 7 17 7 5 0 0.478 1.000 1.000 422 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), ESRRA(2), HDAC5(6), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PPARA(1), PPP3CA(7), PPP3CB(7), PPP3CC(4), SLC2A4(4), SYT1(6), YWHAH(2) 11670640 93 72 93 43 49 9 9 12 14 0 0.970 1.000 1.000 423 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(5), ANXA2(2), ANXA3(3), ANXA4(1), ANXA5(4), ANXA6(6), CYP11A1(1), EDN1(2), EDNRA(4), EDNRB(8), HPGD(1), HSD11B2(3), PLA2G4A(1), PRL(3), PTGDR(3), PTGDS(1), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(6), S100A6(2), TBXAS1(3) 12021185 84 72 84 37 35 5 32 3 9 0 0.892 1.000 1.000 424 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(3), AGTR1(3), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), REN(3) 14486384 84 71 83 34 34 6 27 5 12 0 0.996 1.000 1.000 425 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(4), HRAS(21), JUN(4), MAP2K1(3), MAPK3(8), MYC(2), NFKB1(3), NFKBIA(6), PLCB1(17), PRKCA(3), RAF1(4), RELA(6), TNF(4) 9053064 88 71 78 26 38 3 24 8 15 0 0.446 1.000 1.000 426 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(12), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CYP2C19(7), CYP2C9(3), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1) 18013869 85 71 84 28 37 2 26 5 15 0 0.700 1.000 1.000 427 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(1), ASRGL1(3), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(3), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(4), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), HAL(7) 12378382 87 71 86 27 39 6 20 9 13 0 0.598 1.000 1.000 428 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ENPP1(7), ENPP3(6), FLAD1(9), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), RFK(1), TYR(12) 8779717 88 69 86 28 45 4 19 8 12 0 0.756 1.000 1.000 429 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), SELE(7), SELP(7) 9229964 82 69 81 31 46 3 17 6 10 0 0.816 1.000 1.000 430 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(6), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCS(9), UPB1(4) 8119133 85 69 81 35 38 5 16 16 10 0 0.963 1.000 1.000 431 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(7), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP7(5), CASP8(14), CASP9(6), DFFA(6), DFFB(1), GZMB(2), PRF1(7), SCAP(9), SREBF1(6), SREBF2(8) 10509336 81 69 81 28 42 4 16 6 13 0 0.723 1.000 1.000 432 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(10), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(5), HS2ST1(4), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), NDST1(2), NDST2(2), NDST3(7), NDST4(13) 11958635 77 68 77 36 40 5 15 8 9 0 0.920 1.000 1.000 433 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(1), IL22RA1(4), IL22RA2(3), JAK1(9), JAK2(8), JAK3(12), SOCS3(1), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), TYK2(9) 10651332 81 68 80 32 31 4 14 7 25 0 0.844 1.000 1.000 434 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(7), IFNG(2), IKBKB(11), IL2(1), JUN(4), MAP3K1(10), MAP3K5(14), MAP4K5(4), MAPK14(3), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), TNFRSF9(2), TNFSF9(2), TRAF2(5) 11162507 86 67 84 28 53 2 12 3 16 0 0.767 1.000 1.000 435 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(4), ADSL(4), ADSS(4), AGXT(2), AGXT2(2), ASL(7), ASNS(1), ASPA(2), CAD(16), CRAT(10), DARS(3), DDO(1), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(4), PC(10) 15154734 93 67 92 40 53 3 18 10 9 0 0.907 1.000 1.000 436 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8), MASP1(12), MASP2(5), MBL2(1) 12378608 87 67 87 29 34 5 28 10 10 0 0.718 1.000 1.000 437 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), PGD(5) 10468473 90 67 90 36 45 3 22 5 15 0 0.710 1.000 1.000 438 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(9), DYRK1B(5), GLI2(16), GLI3(19), GSK3B(5), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), SHH(6), SMO(8), SUFU(2) 9663705 92 67 91 24 33 4 34 5 16 0 0.210 1.000 1.000 439 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), LTA(1), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNFAIP3(7), TNFRSF1B(6), TRAF2(5), TRAF3(2) 13016567 87 67 87 22 53 4 12 3 15 0 0.261 1.000 1.000 440 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(28), ACACB(21), FASN(12), MCAT(2), OLAH(4), OXSM(8) 9087372 75 66 73 20 42 6 10 10 7 0 0.161 1.000 1.000 441 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2) 13668577 90 66 89 40 55 4 13 8 10 0 0.978 1.000 1.000 442 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(11), ACE2(5), AGT(3), AGTR1(3), AGTR2(4), ANPEP(6), CMA1(1), CPA3(7), CTSA(3), CTSG(4), ENPEP(9), LNPEP(7), MAS1(2), MME(13), NLN(2), REN(3), THOP1(6) 12312028 89 66 87 34 41 3 20 12 13 0 0.752 1.000 1.000 443 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(6), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(7) 8727356 78 65 73 24 40 2 18 9 9 0 0.379 1.000 1.000 444 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(6), CHAT(5), COMT(3), DBH(4), DDC(8), GAD1(8), GAD2(6), HDC(6), MAOA(4), PAH(11), SLC18A3(5), TH(2), TPH1(3) 8271059 73 64 73 39 25 3 25 8 12 0 0.982 1.000 1.000 445 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C8B(3), C9(8), MASP1(12) 12095257 84 64 84 28 34 5 27 9 9 0 0.717 1.000 1.000 446 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5) 9523377 69 63 69 21 35 1 16 9 8 0 0.472 1.000 1.000 447 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(6), CHPT1(6), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PCYT1A(2), PCYT1B(2), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(7) 8144103 73 62 69 22 42 3 12 8 8 0 0.458 1.000 1.000 448 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(1), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(3), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(4), GLS2(4), GLUD1(6), GLUL(3), HAL(7) 11083784 74 62 73 21 35 4 14 9 12 0 0.426 1.000 1.000 449 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(4), GCK(1), GFPT1(5), GNE(8), GNPDA1(3), GNPDA2(2), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), PGM3(2), RENBP(4), UAP1(5) 9831287 75 61 74 34 37 6 17 5 10 0 0.966 1.000 1.000 450 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(13), DNMT3B(7), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), MTFMT(2), MTR(7), SRM(3), TAT(5) 11994594 71 61 71 28 35 4 16 8 8 0 0.817 1.000 1.000 451 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(10), ST3GAL6(6), ST8SIA1(3) 9371057 79 61 77 29 39 1 18 12 9 0 0.599 1.000 1.000 452 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), BST1(4), CD38(1), ENPP1(7), ENPP3(6), NADK(4), NADSYN1(6), NMNAT2(1), NMNAT3(1), NNMT(3), NNT(8), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT12(3), QPRT(4) 12532409 74 61 73 29 42 5 11 4 12 0 0.894 1.000 1.000 453 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(28), CPT1A(7), LEP(1), LEPR(8), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3) 8483238 67 61 67 21 34 4 9 10 10 0 0.701 1.000 1.000 454 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1) 11903459 73 61 73 41 30 3 23 10 7 0 0.991 1.000 1.000 455 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(3), GOSR1(2), GOSR2(1), SNAP23(3), SNAP25(4), SNAP29(4), STX10(3), STX11(2), STX12(3), STX16(2), STX18(2), STX19(2), STX2(5), STX3(5), STX4(3), STX5(2), STX6(2), STX7(2), STX8(2), TSNARE1(4), USE1(4), VAMP1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(3), VAMP8(2), VTI1A(1), VTI1B(6), YKT6(1) 9641982 78 60 78 28 46 3 16 7 6 0 0.731 1.000 1.000 456 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(7), ARHGAP5(12), ARHGDIB(1), CASP1(9), CASP10(1), CASP3(3), CASP8(14), CASP9(6), CYCS(1), GZMB(2), JUN(4), PRF1(7) 7525762 67 59 65 22 30 4 12 10 11 0 0.844 1.000 1.000 457 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(7), CYP51A1(4), DHCR24(3), DHCR7(3), EBP(1), FDPS(6), GGCX(7), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(4), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4), TM7SF2(1), VKORC1(4) 11122542 72 59 72 19 38 3 15 8 8 0 0.178 1.000 1.000 458 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), NAGLU(5), SPAM1(2) 11836355 70 59 70 23 40 3 11 11 5 0 0.453 1.000 1.000 459 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(9), PSMC3(5), PSMD1(7), PSMD11(4), PSMD12(4), PSMD2(6), PSMD6(3) 9340626 72 59 71 23 44 1 13 8 6 0 0.702 1.000 1.000 460 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(6), CD3E(2), CD3G(2), CXCR3(3), ETV5(4), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), JAK2(8), JUN(4), MAP2K6(1), MAPK14(3), MAPK8(5), STAT4(9), TYK2(9) 10798436 74 59 72 38 36 2 15 6 15 0 0.997 1.000 1.000 461 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(4), IL6R(4), JAK1(9), JAK2(8), JAK3(12), PIAS3(6), PTPRU(7), REG1A(8), SRC(5), STAT3(6) 8831183 70 59 70 18 33 2 21 4 10 0 0.155 1.000 1.000 462 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(5), F13A1(8), F2(3), F2R(2), FGA(17), FGB(5), FGG(7), PLAT(6), PLAU(2), PLG(4), SERPINB2(3), SERPINE1(6) 7811469 68 58 67 19 31 2 16 10 9 0 0.504 1.000 1.000 463 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(3), ARG1(2), ARG2(3), ASL(7), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), NAGS(1), OAT(1), ODC1(4), OTC(2), PYCR1(3), SMS(1) 10130109 72 58 70 24 40 2 12 9 9 0 0.590 1.000 1.000 464 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), NCK1(2), NCKAP1(12), NTRK1(7), PIR(2), RAC1(4), WASF1(5), WASF2(7), WASF3(5), WASL(2) 8905019 70 57 68 23 37 3 14 5 11 0 0.802 1.000 1.000 465 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(4), ARFGEF2(18), CLTA(3), CLTB(1), COPA(12), GBF1(16), GPLD1(5), KDELR2(4), KDELR3(1) 9493504 68 56 68 22 44 6 7 1 10 0 0.502 1.000 1.000 466 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(6), GNAS(12), GNB1(7), PPP2CA(2), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 8942055 72 56 71 16 33 6 17 8 8 0 0.174 1.000 1.000 467 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD2(2), CD33(6), CD5(3), CD7(3), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL5(1), ITGAX(3), TLR2(3), TLR4(6), TLR7(9), TLR9(12) 10838493 63 55 63 28 30 5 14 6 8 0 0.813 1.000 1.000 468 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL5(1), JUNB(5), MAF(3), MAP2K3(6), MAPK14(3), NFATC1(14), NFATC2(13), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7020066 75 55 75 28 27 5 24 7 12 0 0.675 1.000 1.000 469 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(6), B4GALNT1(2), GLB1(5), HEXA(3), HEXB(2), LCT(16), SLC33A1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL5(5), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(3), ST8SIA5(2) 9619087 64 55 64 30 33 3 13 11 4 0 0.906 1.000 1.000 470 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TKTL1(7), TKTL2(5), TPI1(1) 11714053 63 55 63 31 29 1 20 9 4 0 0.941 1.000 1.000 471 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(7), BAK1(2), BAX(2), BCL2L1(4), BID(2), BIK(1), BIRC2(3), BIRC3(3), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DFFB(1), DIABLO(3) 7837497 64 55 63 24 34 4 13 1 12 0 0.938 1.000 1.000 472 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(4), CD3E(2), CD3G(2), CD8A(2), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3) 6263281 65 55 65 25 31 3 16 5 10 0 0.605 1.000 1.000 473 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(4), CD3E(2), CD3G(2), CD4(3), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3) 6570969 66 55 66 26 32 2 16 6 10 0 0.647 1.000 1.000 474 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8) 10164025 69 54 69 25 29 5 22 5 8 0 0.837 1.000 1.000 475 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELE(7) 7028740 62 54 61 21 34 1 13 5 9 0 0.677 1.000 1.000 476 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(13), DNMT3B(7), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), MTR(7) 10102031 61 54 61 23 30 3 15 7 6 0 0.726 1.000 1.000 477 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR7(3), CD28(4), CD4(3), CXCR3(3), CXCR4(4), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL4R(6), IL5(1), TGFB1(3), TGFB3(1) 11623419 69 54 69 34 28 2 16 13 10 0 0.943 1.000 1.000 478 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(5), DAB1(5), FYN(7), LRP8(7), RELN(36), VLDLR(6) 8197876 69 54 69 20 33 4 18 9 5 0 0.601 1.000 1.000 479 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), TNFAIP3(7), TRAF3(2), TRAF6(1) 10519839 66 53 66 18 41 3 7 1 14 0 0.469 1.000 1.000 480 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(5), CLOCK(8), CRY1(3), CRY2(4), CSNK1D(3), CSNK1E(3), NPAS2(8), NR1D1(3), PER1(6), PER2(6), PER3(12) 9864281 61 53 61 26 30 1 16 4 10 0 0.951 1.000 1.000 481 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(2), CCL2(1), CCR5(6), CXCL12(6), CXCR4(4), FOS(4), GNAQ(3), JUN(4), MAPK14(3), MAPK8(5), PLCG1(12), PRKCA(3), PTK2B(6), SYT1(6) 8024865 67 52 65 24 29 5 11 11 11 0 0.699 1.000 1.000 482 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(13), EGF(17), EGFR(7), HGS(11), RAB5A(2), TF(4), TFRC(9) 7521093 63 52 62 22 35 4 11 6 7 0 0.887 1.000 1.000 483 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(5), AFMID(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6) 7826098 59 52 58 19 28 3 19 2 7 0 0.498 1.000 1.000 484 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(3), ATIC(2), FTCD(4), GART(7), MTFMT(2), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3) 11036760 64 52 64 26 30 4 14 6 10 0 0.875 1.000 1.000 485 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(4), ITPKA(4), PDE1A(8), PDE1B(4), PLCB1(17), PLCB2(6), PRL(3), TRH(6) 6429814 57 52 56 19 27 2 16 8 4 0 0.619 1.000 1.000 486 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(7), BRAF(9), CAMP(1), CREB3(5), CREB5(11), RAF1(4), SNX13(5), SRC(5), TERF2IP(4) 6451866 55 51 55 20 24 3 8 11 9 0 0.880 1.000 1.000 487 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(5), ACAT2(1), ACOT11(12), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), FN3K(2), GCDH(6), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1) 15167842 65 50 64 23 35 1 16 3 10 0 0.856 1.000 1.000 488 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(3), IL2RG(5), IL4R(6), IRS1(9), JAK1(9), JAK3(12), RPS6KB1(4), SHC1(8), STAT6(9) 8545155 68 50 68 26 31 1 17 9 9 1 0.760 1.000 1.000 489 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(3), ATIC(2), ATP6V0C(3), GART(7), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3) 10448764 61 50 61 25 32 3 14 4 8 0 0.859 1.000 1.000 490 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4) 10241286 61 50 61 22 27 3 11 11 9 0 0.796 1.000 1.000 491 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(2), EPHB1(14), FYN(7), ITGA1(7), ITGB1(3), L1CAM(8), LYN(5), RAP1B(2), SELP(7) 9223404 59 49 59 18 26 3 17 6 7 0 0.563 1.000 1.000 492 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1) 14554566 61 49 60 18 28 2 18 5 8 0 0.579 1.000 1.000 493 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(6), CD2(2), CD3E(2), CD3G(2), CD4(3), CXCR3(3), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), JAK2(8), STAT4(9), TYK2(9) 8489089 58 49 58 28 22 3 15 6 12 0 0.975 1.000 1.000 494 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(9), JAK2(8), JAK3(12), PIAS1(3), PIAS3(6), PTPRU(7), REG1A(8), SOAT1(5) 7938106 59 49 59 19 26 2 18 3 10 0 0.516 1.000 1.000 495 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(13), RXRA(25), TNF(4) 3385167 52 49 36 18 29 2 9 3 9 0 0.643 1.000 1.000 496 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(5), EGR1(7), HRAS(21), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), NGFR(4), RAF1(4) 4755257 61 48 53 23 17 3 22 7 12 0 0.688 1.000 1.000 497 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(7), ICAM1(7), ITGAL(17), ITGB2(7), PRF1(7) 5075094 54 48 53 22 20 0 16 7 11 0 0.651 1.000 1.000 498 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(15), KHK(1), LCT(16), MPI(7), PGM1(3), PYGL(4), PYGM(13), TPI1(1), TREH(5) 7756453 65 48 64 28 33 4 16 5 7 0 0.752 1.000 1.000 499 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6) 7473972 54 48 53 19 25 2 19 2 6 0 0.644 1.000 1.000 500 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(5), B3GAT3(3), B4GALT7(1), CHPF(4), CHST11(2), CHST12(3), CHST14(3), CHST7(2), CHSY1(9), DSE(6), UST(4), XYLT1(6), XYLT2(6) 7961671 55 48 52 30 29 2 13 5 6 0 0.936 1.000 1.000 501 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(7), ITGAL(17), ITGAM(13), ITGB2(7), SELE(7) 5987153 53 48 52 23 29 1 14 3 6 0 0.772 1.000 1.000 502 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ENPP1(7), ENPP3(6), FLAD1(9), RFK(1), TYR(12) 5664987 62 48 60 22 30 3 15 4 10 0 0.808 1.000 1.000 503 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME2(1), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TPI1(1) 10461276 52 47 52 26 25 1 16 7 3 0 0.941 1.000 1.000 504 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), IDS(4), IDUA(1), LCT(16), NAGLU(5) 8306878 52 47 52 15 31 3 8 7 3 0 0.304 1.000 1.000 505 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(10), ACO1(4), ACO2(5), ACSS1(7), ACSS2(3), FH(7), IDH1(9), IDH2(2), MDH1(3), SUCLA2(2) 7760514 52 47 52 31 26 3 6 9 8 0 0.989 1.000 1.000 506 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), AOC2(5), AOC3(6), CES1(4), DDHD1(11), ESCO1(3), ESCO2(3), LIPA(3), NAT6(1), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(1) 14716988 53 47 53 13 29 4 9 7 4 0 0.371 1.000 1.000 507 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(16), ABCB11(4), ABCB4(11), ABCC1(10), ABCC3(16), GSTP1(2) 8339112 59 47 58 20 35 4 10 5 5 0 0.332 1.000 1.000 508 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(21), MMP14(4), MMP2(7), MMP9(6), RECK(8), TIMP1(2), TIMP2(4), TIMP4(3) 4372162 55 47 47 21 20 3 21 4 7 0 0.760 1.000 1.000 509 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(9), JAK2(8), JAK3(12), MAPK3(8), STAT3(6), TYK2(9) 6769111 52 47 52 24 20 4 12 3 13 0 0.937 1.000 1.000 510 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(1), JAK1(9), PTPRU(7), REG1A(8), STAT1(13), STAT2(4), TYK2(9) 7270570 53 46 52 21 17 3 17 4 11 1 0.681 1.000 1.000 511 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(4), CD86(6), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL2RA(1), IL4R(6) 7382887 48 46 48 20 19 2 13 8 6 0 0.882 1.000 1.000 512 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8) 7318348 53 45 53 19 24 5 16 4 4 0 0.851 1.000 1.000 513 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(3), FOS(4), JUN(4), MAPK3(8), OPRK1(4), POLR2A(13), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7475395 58 45 56 21 30 3 13 3 9 0 0.678 1.000 1.000 514 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), NTAN1(2), SIRT1(9), SIRT2(2), SIRT5(3), SIRT7(4), VNN2(4) 6900744 48 45 46 15 32 3 3 3 7 0 0.753 1.000 1.000 515 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(3), FH(7), IDH2(2), MDH1(3), OGDH(21), SDHA(9), SUCLA2(2) 5497154 52 45 49 16 25 3 11 7 6 0 0.451 1.000 1.000 516 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(6), CTSD(6), ESR1(5), GREB1(17), HSPB1(1), HSPB2(4), MTA1(5), MTA3(1), PDZK1(2), TUBA8(2) 6210655 49 45 48 16 15 2 23 4 5 0 0.408 1.000 1.000 517 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(7), ENPP3(6), NADSYN1(6), NMNAT2(1), NNMT(3), NNT(8), NT5C(1), NT5E(6), QPRT(4) 8467349 51 45 50 19 30 3 7 4 7 0 0.797 1.000 1.000 518 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(7), DLL1(9), FURIN(9), NOTCH1(17), PSEN1(8) 5199560 50 45 48 16 22 3 15 1 7 2 0.461 1.000 1.000 519 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(4), JUN(4), KEAP1(9), MAFG(1), MAFK(1), MAPK14(3), MAPK8(5), NFE2L2(25), PRKCA(3) 5084772 55 44 44 19 31 1 10 6 7 0 0.774 1.000 1.000 520 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(14), ANKRD1(1), CYR61(6), DUSP14(4), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(6), IL1A(1), IL1R1(1), JUND(2), MYOG(2), NR4A3(5), WDR1(3) 6208349 51 44 48 16 32 3 6 3 7 0 0.618 1.000 1.000 521 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(6), ADRB2(3), GNAS(12), PLCE1(11), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAP2B(1) 8621275 55 44 55 20 23 2 15 6 9 0 0.774 1.000 1.000 522 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(4), CD3E(2), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10), TOB1(5), TOB2(2) 6161601 48 44 48 21 23 3 9 2 10 1 0.926 1.000 1.000 523 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2A(2), UBE2B(2), UBE2C(5), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2H(3), UBE2I(1), UBE2J1(5), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2N(4), UBE2S(2), UBE3A(10) 6125902 53 44 51 17 30 5 5 8 5 0 0.730 1.000 1.000 524 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), SDS(2) 7052603 48 43 47 20 24 2 8 5 9 0 0.806 1.000 1.000 525 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(6), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(2), CPT1A(7), CPT2(5), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(3) 9805244 47 43 47 16 25 1 10 6 5 0 0.727 1.000 1.000 526 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(5), GALNT10(3), GALNT2(8), GALNT3(5), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), WBSCR17(9) 8417000 58 43 58 17 26 4 17 5 6 0 0.409 1.000 1.000 527 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CARS2(7), CDO1(2), CTH(5), GOT1(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MPST(1), SDS(2), SULT1B1(5), SULT1C2(4), SULT1C4(4) 7304186 47 42 46 17 23 5 10 2 7 0 0.757 1.000 1.000 528 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), IMPA2(4), ISYNA1(2), PGM1(3), PGM3(2), TGDS(3) 6757795 50 42 49 26 21 3 13 3 10 0 0.970 1.000 1.000 529 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(4), ACOX1(7), ACOX3(7), ELOVL2(2), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(2), FASN(12), HADHA(4), HSD17B12(3), SCD(2) 8249688 48 42 48 21 20 3 11 5 9 0 0.755 1.000 1.000 530 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(7), CASP3(3), CASP9(6), CYCS(1), DAXX(9), FAS(1), FASLG(1), HSPB1(1), HSPB2(4), IL1A(1), MAPKAPK2(1), MAPKAPK3(3), TNF(4) 6605523 46 42 46 26 21 5 12 1 7 0 0.994 1.000 1.000 531 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(4), HPRT1(1), IMPDH1(1), MTHFD2(6), NME2(3), OAZ1(4), POLD1(10), POLG(8), PRPS2(1), RRM1(4), SRM(3) 7223915 49 41 49 13 22 6 14 1 6 0 0.361 1.000 1.000 532 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(4), CNR2(6), DNMT1(11), MTNR1A(4), MTNR1B(1), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2) 6441056 51 41 51 25 22 4 17 2 6 0 0.695 1.000 1.000 533 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CAMKK1(3), CAMKK2(5), SYT1(6) 6669495 50 40 50 30 27 4 5 5 9 0 0.997 1.000 1.000 534 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(12), ALAS2(5), CPOX(5), FECH(3), PPOX(6), UROD(4), UROS(4) 4349525 44 40 44 19 20 3 4 7 10 0 0.946 1.000 1.000 535 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), NAT1(4), NAT2(1), XDH(11) 4683662 42 40 40 15 24 2 8 5 3 0 0.432 1.000 1.000 536 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(6), CAPN1(5), CAPNS2(1), CDK5(3), CDK5R1(5), CSNK1A1(6), CSNK1D(3), GSK3B(5), MAPT(10), PPP2CA(2) 5334023 46 40 46 29 23 1 10 3 9 0 0.999 1.000 1.000 537 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(2), GSS(7), NFKB1(3), NOX1(4), RELA(6), SOD1(4), TNF(4), XDH(11) 5747866 43 39 43 13 24 0 10 2 7 0 0.318 1.000 1.000 538 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(6), IFNB1(1), JAK1(9), STAT1(13), STAT2(4), TYK2(9) 6297014 45 39 44 16 16 3 9 3 13 1 0.625 1.000 1.000 539 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(11), AGT(3), AGTR1(3), AGTR2(4), BDKRB2(3), KNG1(5), NOS3(11), REN(3) 5659014 43 38 42 21 19 2 13 4 5 0 0.829 1.000 1.000 540 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(3), CASP7(5), DFFA(6), DFFB(1), GZMB(2), HMGB1(4), HMGB2(6), TOP2A(13), TOP2B(5) 5161152 45 38 45 13 28 2 6 5 4 0 0.818 1.000 1.000 541 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(7), ERBB4(11), NRG2(3), NRG3(8), PRKCA(3), PSEN1(8) 5238652 40 38 40 11 16 2 10 4 8 0 0.549 1.000 1.000 542 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(5), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), CHST1(2), CHST2(1), CHST4(3), CHST6(1), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1) 7249622 43 38 42 31 21 0 9 9 4 0 0.997 1.000 1.000 543 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(5), ALOX15B(3), ALOX5(4), DPEP1(2), GGT1(5), LTA4H(3), PLA2G2A(2), PLA2G6(4), PTGDS(1), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3) 8658093 44 37 44 24 20 2 10 5 7 0 0.915 1.000 1.000 544 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(2), GPR161(8), GPR171(3), GPR18(3), GPR39(4), GPR45(4), GPR65(3), GPR68(5), GPR75(9) 5743118 41 37 40 18 19 3 9 5 5 0 0.461 1.000 1.000 545 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(4), AASDH(13), AASS(11), KARS(11) 4073260 39 37 39 12 24 3 7 3 2 0 0.787 1.000 1.000 546 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(2) 5099611 41 37 40 13 25 1 8 5 2 0 0.647 1.000 1.000 547 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5) 7771103 48 37 48 25 30 2 5 6 5 0 0.984 1.000 1.000 548 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), PGM1(3), PGM3(2), TGDS(3) 5940854 44 37 43 23 19 3 11 2 9 0 0.970 1.000 1.000 549 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(12), GNB1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3) 5599472 48 36 47 12 22 5 11 5 5 0 0.373 1.000 1.000 550 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(12), ALAS2(5), CPO(3), FECH(3), GATA1(6), HBB(1), UROD(4), UROS(4) 4456460 43 36 43 15 19 4 4 5 11 0 0.771 1.000 1.000 551 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(7), FADS2(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4) 5864885 40 36 40 23 17 0 10 4 9 0 0.982 1.000 1.000 552 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(3), CSF1(4), CSF3(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(4), IL7(1), LTA(1), TGFB1(3), TGFB3(1), TNF(4) 7668150 40 36 40 16 23 0 10 3 4 0 0.571 1.000 1.000 553 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(9), HSD17B1(1), HSD17B2(6), HSD17B3(1), HSD17B4(5), HSD17B7(3), HSD3B1(5), HSD3B2(5) 4720980 38 36 38 15 22 2 5 5 4 0 0.775 1.000 1.000 554 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(7), MAPK14(3), MAPK8(5), NFKB1(3), RELA(6), TNFRSF13B(1), TNFRSF13C(3), TNFRSF17(2), TNFSF13(2), TNFSF13B(5), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1) 8408660 46 36 46 14 30 1 7 2 6 0 0.554 1.000 1.000 555 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(21), GNA12(3), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5) 5886779 43 35 43 12 22 1 8 5 7 0 0.591 1.000 1.000 556 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(4), HDAC9(8), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), YWHAH(2) 4358814 38 35 38 15 17 5 5 4 7 0 0.851 1.000 1.000 557 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(6), CREM(3), FHL5(4), FSHB(1), FSHR(5), GNAS(12), XPO1(7) 5604723 38 34 38 16 21 0 7 4 6 0 0.916 1.000 1.000 558 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(3), MDH1(3), ME1(5), PC(10), PDHA1(5), SLC25A1(1), SLC25A11(2) 5386137 39 34 39 25 21 0 11 4 3 0 0.983 1.000 1.000 559 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(3), NFKBIA(6), PLCB1(17), PRKCA(3), RELA(6) 4778112 38 34 38 11 25 1 8 3 1 0 0.526 1.000 1.000 560 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(7), BAD(3), BAK1(2), BAX(2), BCL10(3), BCL2L1(4), BCL2L11(3), BID(2), CASP9(6), CES1(4) 6211003 36 34 35 11 9 5 9 2 11 0 0.857 1.000 1.000 561 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(2), CTH(5), GGT1(5), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(2), SEPHS1(2) 7181033 37 34 37 21 18 2 12 1 4 0 0.965 1.000 1.000 562 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7) 4626946 35 33 34 14 15 1 8 5 6 0 0.697 1.000 1.000 563 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(6), CHAT(5), CHKA(5), PCYT1A(2), PDHA1(5), PDHA2(6), PEMT(1), SLC18A3(5) 3996273 35 33 35 22 12 2 14 4 3 0 0.983 1.000 1.000 564 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7) 4626946 35 33 34 14 15 1 8 5 6 0 0.697 1.000 1.000 565 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(3), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST8SIA1(3) 6224947 35 33 35 17 15 1 12 3 4 0 0.874 1.000 1.000 566 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(4), IL1B(3), MST1(10), MST1R(16), TNF(4) 3802040 38 33 38 24 16 2 9 3 8 0 0.981 1.000 1.000 567 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(7), CYCS(1), GPD2(10), NDUFA1(1), SDHA(9), SDHB(2), SDHC(2), SDHD(4), UQCRC1(2) 3866268 38 32 38 11 18 2 12 2 4 0 0.591 1.000 1.000 568 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(3), GPI(4), HK1(15), PFKL(2), PGAM1(1), PGK1(2), PKLR(8), TPI1(1) 5368723 39 32 39 22 17 1 12 4 5 0 0.946 1.000 1.000 569 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(2), ENO3(4), FARS2(1), GOT1(2), PAH(11), TAT(5), YARS(5) 4853154 33 32 33 12 11 1 5 7 9 0 0.692 1.000 1.000 570 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(5), CCNH(4), CDC25A(5), CDC25B(2), CDC25C(2), CDK7(6), MNAT1(4), SHH(6), XPO1(7) 5052462 41 32 40 16 28 2 5 1 5 0 0.929 1.000 1.000 571 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9) 6104608 34 32 34 16 9 2 9 6 8 0 0.957 1.000 1.000 572 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9) 6104608 34 32 34 16 9 2 9 6 8 0 0.957 1.000 1.000 573 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(2), CD4(3), FYN(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(19), ZAP70(3) 5270758 43 32 43 21 18 0 14 7 4 0 0.955 1.000 1.000 574 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(5), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6) 4039204 38 32 36 12 24 0 8 2 4 0 0.737 1.000 1.000 575 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(2), CSF3(1), EPO(2), FLT3(10), IGF1(2), IL1A(1), IL6(4), KITLG(5), TGFB1(3), TGFB3(1) 4762675 31 31 31 11 19 1 7 0 4 0 0.597 1.000 1.000 576 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST8SIA1(3) 5858469 32 31 32 17 12 1 11 3 5 0 0.922 1.000 1.000 577 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(5), FH(7), IDH1(9), IDH2(2), MDH1(3), SDHB(2), SUCLA2(2) 5199412 34 31 34 14 19 2 5 5 3 0 0.820 1.000 1.000 578 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(5), ACAT2(1), BDH2(3), HMGCL(1), HMGCS1(9), HMGCS2(7), OXCT1(4), OXCT2(2) 4204082 32 30 32 12 16 2 6 5 3 0 0.827 1.000 1.000 579 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CSK(7), GRB2(3), PRKCA(3), PTPRA(2), SRC(5) 5374586 34 30 34 24 21 2 9 2 0 0 0.997 1.000 1.000 580 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), CKM(5), EIF4E(2), FBL(2), GPT(2), LDHB(2), LDHC(4), MAPK14(3), NCL(3) 5229814 29 29 29 15 18 2 6 1 2 0 0.953 1.000 1.000 581 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(5), CLOCK(8), CRY1(3), CRY2(4), CSNK1E(3), PER1(6) 4876676 29 28 29 11 12 0 9 2 6 0 0.864 1.000 1.000 582 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(6), GNAS(12), GNB1(7), PRKACA(2), PRKAR1A(3) 3861208 30 28 29 14 15 3 7 2 3 0 0.887 1.000 1.000 583 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), MIOX(2), UGDH(5) 4923620 31 28 31 12 10 2 7 6 6 0 0.693 1.000 1.000 584 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(2), FOS(4), FYN(7), JUN(4), MAPK14(3), THBS1(8) 4319310 31 28 29 13 14 0 9 4 4 0 0.895 1.000 1.000 585 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HSD3B7(2), PON1(6), PON2(2), PON3(3), RDH12(2), RDH13(1) 5235485 32 27 30 18 11 0 13 2 6 0 0.949 1.000 1.000 586 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6) 3691193 26 26 24 17 13 2 6 1 4 0 0.903 1.000 1.000 587 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6) 3691193 26 26 24 17 13 2 6 1 4 0 0.903 1.000 1.000 588 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(3), FUT2(6), FUT9(3), GCNT2(10), ST8SIA1(3) 3559098 28 25 28 13 11 1 8 5 3 0 0.839 1.000 1.000 589 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(4), AASS(11), KARS(11) 2758501 26 25 26 11 19 1 4 1 1 0 0.947 1.000 1.000 590 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(2), CHST12(3), PAPSS1(4), PAPSS2(2), SULT1A1(3), SULT1A2(1), SULT1E1(1), SULT2A1(4), SULT2B1(2), SUOX(3) 5384806 27 25 26 20 16 2 4 4 1 0 0.997 1.000 1.000 591 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1) 4571457 28 25 28 13 14 0 6 5 3 0 0.834 1.000 1.000 592 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(3), CDO1(2), CSAD(3), GAD1(8), GAD2(6), GGT1(5) 3329217 27 24 27 14 11 2 8 2 4 0 0.932 1.000 1.000 593 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(6), PARK2(4), SNCA(1), SNCAIP(8), UBE2E2(1), UBE2F(1), UBE2L3(2), UBE2L6(2) 3754340 25 23 25 10 11 3 3 3 5 0 0.859 1.000 1.000 594 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), GCDH(6), HADHA(4), SDHB(2), SDS(2) 4551112 27 22 27 12 18 1 2 1 5 0 0.910 1.000 1.000 595 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(3), CD3E(2), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL6(4), KITLG(5) 3612454 25 22 25 13 11 2 7 1 4 0 0.920 1.000 1.000 596 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(8), HDC(6), TH(2), TPH1(3) 3446149 23 22 23 12 11 1 6 1 4 0 0.913 1.000 1.000 597 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1) 9685560 27 21 26 12 10 1 11 2 3 0 0.948 1.000 1.000 598 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(7), BMPR1A(3), BMPR1B(5), BMPR2(9) 3642933 24 21 23 10 13 1 3 1 6 0 0.902 1.000 1.000 599 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(5), ALPL(4), ALPP(3), FPGS(4), GCH1(2), GGH(3) 3683789 21 20 21 12 10 0 8 1 2 0 0.845 1.000 1.000 600 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(12), PRKCA(3), PTK2B(6) 3907826 22 20 22 14 11 2 5 2 2 0 0.944 1.000 1.000 601 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(3), CASP8(14), CFL1(1), CFLAR(2) 2251441 20 20 20 10 10 1 2 2 5 0 0.907 1.000 1.000 602 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(4), NR1I3(4), PTGS1(2), PTGS2(6) 3136003 20 19 20 12 9 3 5 2 1 0 0.920 1.000 1.000 603 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(4), COQ5(5), COQ6(7), NDUFA12(1), NDUFA13(3) 2310212 22 19 22 12 13 3 2 1 3 0 0.972 1.000 1.000 604 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(3), GRIA2(7), JUND(2), PPP1R1B(5) 2161565 20 18 20 13 11 0 4 3 2 0 0.988 1.000 1.000 605 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(5), PNPO(2), PSAT1(6) 2831492 21 18 21 10 7 0 2 3 9 0 0.920 1.000 1.000 606 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(3), CD8A(2), CSF1(4), CSF3(1), EPO(2), IL2(1), IL5(1), IL6(4), IL7(1) 3489735 19 18 19 10 11 1 5 2 0 0 0.834 1.000 1.000 607 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(4), GGT1(5), SHMT1(3), SHMT2(2) 3137199 17 16 17 13 5 1 7 1 3 0 0.987 1.000 1.000 608 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(2), CTH(5), MUT(9) 2855059 17 16 17 5 11 1 2 3 0 0 0.620 1.000 1.000 609 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(4), SUOX(3) 3581651 17 16 17 12 9 1 4 2 1 0 0.994 1.000 1.000 610 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(6), ALDH1A2(6), BCMO1(3) 2281033 15 15 14 6 9 0 4 2 0 0 0.703 1.000 1.000 611 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(6), PRKCA(3), TGM2(2) 2861448 12 12 12 12 5 0 4 2 1 0 0.995 1.000 1.000 612 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(6), CD28(4), CD3E(2), CD3G(2), CD4(3) 1881739 17 12 17 11 6 1 4 4 2 0 0.948 1.000 1.000 613 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(4), HSD3B7(2), RDH12(2), RDH13(1) 2776382 10 9 10 12 5 2 1 1 1 0 0.997 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(3) 1049299 6 6 6 5 3 2 1 0 0 0 0.957 1.000 1.000 615 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 960891 1 1 1 2 1 0 0 0 0 0 0.982 1.000 1.000 616 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 421699 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000