rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(8) 1005449 8 8 8 0 3 0 3 0 2 0 0.130 0.493 1.000 2 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7), CYP2C9(3) 1188571 10 10 10 2 3 0 6 0 1 0 0.372 0.587 1.000 3 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(5), LIPT1(1) 897135 6 5 6 0 4 1 1 0 0 0 0.293 0.735 1.000 4 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NFS1(5), THTPA(2), TPK1(4) 3725882 35 32 35 4 20 0 5 5 5 0 0.0696 0.750 1.000 5 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4) 3308380 25 24 25 3 11 1 6 2 5 0 0.0653 0.784 1.000 6 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 299386 1 1 1 0 1 0 0 0 0 0 0.748 0.790 1.000 7 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(3), FMOD(3), KERA(7), LUM(2) 2112006 17 16 17 2 9 0 5 2 1 0 0.0853 0.802 1.000 8 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(9), IFNG(2), IL12A(1), IL12B(3), IL2(1) 1737741 16 16 16 3 9 0 4 1 2 0 0.326 0.837 1.000 9 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(8), GOT1(2), TAT(5), TYR(12) 2741084 27 23 27 4 12 1 9 1 4 0 0.0860 0.846 1.000 10 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(3), GNB1(7), HTR2C(1), PLCB1(17), TUB(4) 4164702 34 31 33 4 19 2 9 3 1 0 0.0217 0.876 1.000 11 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(12), SPCS3(1) 1788894 15 15 15 4 7 1 4 1 2 0 0.394 0.887 1.000 12 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(4), CD4(3), HLA-DRA(4), HLA-DRB1(1) 1383675 12 12 12 4 6 1 3 2 0 0 0.498 0.946 1.000 13 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(4), BIRC3(3), CASP8(14), FADD(7), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 4817772 57 49 55 9 36 1 7 4 9 0 0.0280 0.946 1.000 14 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(6), IDI1(2), SQLE(4) 1843674 12 12 12 2 6 0 3 2 1 0 0.313 0.969 1.000 15 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 664914 4 3 4 3 1 0 2 0 1 0 0.943 0.975 1.000 16 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(6), CES1(4), ESD(3) 3501402 18 18 18 3 7 0 5 4 2 0 0.191 0.988 1.000 17 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(5) 1526099 7 7 7 2 4 0 0 1 2 0 0.615 0.989 1.000 18 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(7), CPS1(13), GLS(4), GLUD1(6), GOT1(2) 4538906 34 28 32 5 18 1 5 5 5 0 0.0719 0.992 1.000 19 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 6 CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), TFDP1(2) 2808284 29 29 24 6 20 0 6 1 2 0 0.181 0.994 1.000 20 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 6 CREBBP(50), ESR1(5), MAPK3(8), PELP1(5), SRC(5) 5578594 73 70 69 15 21 2 19 6 24 1 0.0781 0.996 1.000 21 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL5(1) 1774605 10 10 10 4 3 0 4 2 1 0 0.723 0.996 1.000 22 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(2), HGD(4) 1306225 9 9 9 4 5 0 0 2 2 0 0.814 0.998 1.000 23 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(7), CYP11A1(1), CYP11B2(13), CYP17A1(3), HSD11B2(3), HSD3B1(5), HSD3B2(5) 4025170 37 32 37 8 19 1 13 4 0 0 0.0452 0.998 1.000 24 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(4), CCNE1(3), CDC34(1), CDK2(1), CUL1(19), E2F1(3), SKP2(5), TFDP1(2) 3949781 38 38 33 8 25 0 8 2 3 0 0.149 0.998 1.000 25 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDPS(6), HMGCR(7), IDI1(2), LSS(7), MVD(4), NQO2(3), PMVK(1), SQLE(4), VKORC1(4) 6362305 41 36 41 5 22 2 7 5 5 0 0.0123 0.999 1.000 26 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(6), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5) 5333840 48 39 48 9 24 3 15 5 1 0 0.0186 0.999 1.000 27 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(5), AKR1D1(5), CYP11A1(1), CYP11B1(6), CYP11B2(13), CYP17A1(3), CYP21A2(2), HSD11B2(3), HSD3B1(5), HSD3B2(5) 5333840 48 39 48 9 24 3 15 5 1 0 0.0186 0.999 1.000 28 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(5), CCL2(1), CSF1(4), IL6(4), LDLR(10), LPL(4) 3116487 28 28 28 7 14 0 4 2 8 0 0.364 0.999 1.000 29 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(2) 1229445 5 5 5 3 1 1 2 1 0 0 0.889 0.999 1.000 30 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(3), UGDH(5), UGP2(9), UXS1(3) 2849723 23 21 21 5 9 3 3 3 5 0 0.411 1.000 1.000 31 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(6), JAK1(9), JAK2(8), STAT1(13) 4799687 39 35 38 7 17 1 7 3 11 0 0.182 1.000 1.000 32 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 5 FABP6(1), LDLR(10), NR0B2(2), NR1H3(4), NR1H4(4) 2620669 21 19 21 5 8 1 6 1 5 0 0.279 1.000 1.000 33 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(2), SNAP25(4), STX1A(1), VAMP2(1) 1901498 10 10 10 4 5 1 3 1 0 0 0.634 1.000 1.000 34 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(4), GLUD1(6), GLUD2(10) 2657960 24 22 23 6 10 1 7 2 4 0 0.481 1.000 1.000 35 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(4), CD4(3), CD80(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(1) 2318348 16 16 16 5 9 1 4 2 0 0 0.422 1.000 1.000 36 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(5), ACAT2(1), HMGCL(1), OXCT1(4) 1983004 11 10 11 7 7 1 0 1 2 0 0.975 1.000 1.000 37 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 GRB2(3), PTK2B(6), SHC1(8), SOS1(23), SRC(5) 4868716 45 38 44 8 26 1 9 6 3 0 0.122 1.000 1.000 38 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT2(6), FUT3(3), FUT5(5), FUT6(2), ST3GAL3(3) 2957408 22 21 21 6 13 0 7 0 2 0 0.230 1.000 1.000 39 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(5), BLVRB(1), HMOX1(3), IL10(1), IL10RA(9), IL10RB(9), IL1A(1), IL6(4), JAK1(9), STAT1(13), STAT3(6), STAT5A(1), TNF(4) 7122262 66 56 65 12 29 0 12 3 22 0 0.0107 1.000 1.000 40 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), RAC1(4), WASF1(5), WASL(2) 4739468 39 35 39 7 19 3 5 4 8 0 0.207 1.000 1.000 41 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(3), GGT1(5), SHMT1(3), SHMT2(2) 2375220 13 11 13 9 5 0 5 0 3 0 0.936 1.000 1.000 42 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TPO(16), TYR(12) 5592311 63 50 62 14 30 3 19 4 6 1 0.0579 1.000 1.000 43 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(1), RAB3A(2), RAB5A(2), RAB6A(5), RAB9A(1) 2475444 17 15 17 6 7 2 2 3 3 0 0.791 1.000 1.000 44 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25A(5), CDC25B(2), CDK7(6), CHEK1(3), NEK1(5), WEE1(10) 3772729 31 26 31 7 18 5 1 0 7 0 0.709 1.000 1.000 45 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 10 CREBBP(50), DAXX(9), PAX3(11), PML(14), RARA(6), SIRT1(9), SP100(13), TNF(4), TNFRSF1A(5), TNFRSF1B(6) 9231312 127 103 121 23 54 1 33 10 28 1 0.0158 1.000 1.000 46 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(4), DHCR7(3), FDPS(6), HMGCR(7), HMGCS1(9), IDI1(2), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4) 7606406 50 44 50 8 28 2 8 8 4 0 0.0289 1.000 1.000 47 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(6), GOT1(2), PAH(11), TAT(5), YARS(5), YARS2(8) 5069669 40 37 40 9 17 2 5 7 9 0 0.201 1.000 1.000 48 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(3), UGDH(5), UXS1(3) 2231739 14 13 14 5 4 2 3 3 2 0 0.770 1.000 1.000 49 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(1), EHHADH(6), HADHA(4), SDS(2) 2817763 15 15 15 8 11 1 0 0 3 0 0.918 1.000 1.000 50 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(3), B3GALT5(3), B3GNT5(8), FUT1(3), FUT2(6), FUT3(3), ST3GAL3(3), ST3GAL4(1) 4212211 32 23 32 9 22 0 7 1 2 0 0.265 1.000 1.000 51 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(13), GABARAP(3), GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPHN(5), NSF(6), SRC(5), UBQLN1(5) 6922805 88 70 87 18 29 4 25 19 11 0 0.0798 1.000 1.000 52 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(6), GGPS1(1), IDI1(2), IDI2(4), SQLE(4) 2479141 17 17 17 5 7 0 6 3 1 0 0.587 1.000 1.000 53 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(6), ACAT1(5), ECHS1(1), HADHA(4) 3151489 19 19 19 8 11 0 3 2 3 0 0.874 1.000 1.000 54 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(65), ATR(32), CDC25C(2), CHEK1(3), CHEK2(11), YWHAH(2) 8894561 115 90 111 15 54 7 13 18 21 2 0.0247 1.000 1.000 55 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(6), ALDOB(3), ALDOC(2), TPI1(1) 2282528 12 12 12 9 5 1 3 2 1 0 0.979 1.000 1.000 56 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 5 CREBBP(50), LPL(4), NCOA1(25), NCOA2(12), PPARG(13) 7325451 104 86 98 19 39 2 22 8 32 1 0.0940 1.000 1.000 57 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GPX1(2), PRKCE(5), SOD1(4) 4593551 62 54 62 15 16 3 20 15 8 0 0.234 1.000 1.000 58 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(17), EGFR(7), ERBB3(48), NRG1(18), UBE2D1(2) 6010906 92 79 81 19 41 7 25 11 8 0 0.112 1.000 1.000 59 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(6), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST3GAL5(5), ST6GALNAC4(2), ST8SIA1(3) 3277672 21 19 21 9 7 1 3 7 3 0 0.692 1.000 1.000 60 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(4), FOSL1(3), FOSL2(5), IFNAR1(2), IFNAR2(6), IFNB1(1), MAPK8(5), NFKB1(3), RELA(6), TNFRSF11A(1), TNFSF11(1), TRAF6(1) 6421901 38 34 37 9 19 1 5 1 11 1 0.548 1.000 1.000 61 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(7), DNAJC3(6), EIF2S1(5), EIF2S2(1), NFKB1(3), NFKBIA(6), RELA(6) 5177373 34 28 34 6 23 2 2 1 6 0 0.209 1.000 1.000 62 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(7), SRP19(1), SRP54(3), SRP68(12), SRP72(6), SRP9(1), SRPR(3) 4424152 33 30 33 9 19 1 2 5 6 0 0.547 1.000 1.000 63 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(4), LPO(8), MPO(4), PRDX6(5), TPO(16) 4842840 43 38 43 11 19 2 14 4 4 0 0.192 1.000 1.000 64 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5) 3476319 20 20 20 6 10 1 5 4 0 0 0.479 1.000 1.000 65 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(14), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(3), APOBEC3F(1), APOBEC4(7) 4289239 33 29 33 9 23 2 6 2 0 0 0.359 1.000 1.000 66 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(4), ACAA2(2), ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), SDS(2) 4887057 29 25 28 9 19 2 0 1 7 0 0.674 1.000 1.000 67 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(3), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(4), IL6(4) 3126878 23 20 23 9 11 1 5 4 2 0 0.680 1.000 1.000 68 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(3), CAT(9), EPX(6), LPO(8), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16) 6839783 69 56 68 16 36 2 17 6 7 1 0.0516 1.000 1.000 69 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(4), GLUD1(6), OAT(1), PRODH(3) 3204178 20 19 19 7 12 2 3 1 2 0 0.742 1.000 1.000 70 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), P2RY1(3), P2RY2(1), P2RY6(2) 3479393 17 15 17 9 5 1 4 6 1 0 0.696 1.000 1.000 71 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(6), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(2) 5836285 37 32 37 7 20 1 6 3 7 0 0.283 1.000 1.000 72 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(2), RANBP2(28), RANGAP1(4) 4925357 35 32 35 8 19 4 5 2 5 0 0.710 1.000 1.000 73 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL16(13), IL1A(1), IL2(1), IL5(1), IL6(4), LTA(1), TNF(4) 5783775 35 31 35 9 22 0 7 2 4 0 0.222 1.000 1.000 74 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5), CTH(5), GOT1(2), LDHB(2), LDHC(4), MPST(1) 3992401 19 19 19 9 10 2 4 1 2 0 0.894 1.000 1.000 75 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3) 8771309 81 65 80 17 40 6 12 11 12 0 0.0400 1.000 1.000 76 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3) 8771309 81 65 80 17 40 6 12 11 12 0 0.0400 1.000 1.000 77 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), SHMT1(3) 8771309 81 65 80 17 40 6 12 11 12 0 0.0400 1.000 1.000 78 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(9), LDLR(10), MBTPS1(13), MBTPS2(7), SCAP(9), SREBF1(6), SREBF2(8) 6841875 62 55 61 17 30 1 14 4 13 0 0.187 1.000 1.000 79 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(1), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(6), PPT1(1) 4925239 29 22 27 9 21 3 1 1 3 0 0.544 1.000 1.000 80 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(29), CDH1(15), CREBBP(50), MAP2K1(3), MAP3K7(8), MAPK3(8), SKIL(15), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8) 12076571 147 105 143 24 54 4 24 11 51 3 0.0331 1.000 1.000 81 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(4), CCNA2(3), CCND1(4), CCNE1(3), CCNE2(8), CDK2(1), CDK4(6), CDKN1B(6), E2F1(3), E2F2(4), E2F4(2), PRB1(2) 4851391 46 39 45 11 24 2 7 2 11 0 0.337 1.000 1.000 82 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC3(5), RPN1(3), RPN2(5), UBE2A(2), UBE3A(10) 7496769 59 53 58 12 37 1 9 7 5 0 0.138 1.000 1.000 83 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(7), CREBBP(50), FADD(7), HDAC3(1), IKBKB(11), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1) 10052724 116 97 111 26 51 2 20 7 35 1 0.104 1.000 1.000 84 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MPO(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), TAT(5), TPO(16) 12703476 104 78 103 24 50 3 26 9 15 1 0.0123 1.000 1.000 85 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(12), EIF2AK4(11), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF5(9), GSK3B(5), PPP1CA(8) 6762412 68 52 68 13 36 1 15 6 10 0 0.174 1.000 1.000 86 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), FDXR(5), SHMT1(3) 9323680 86 68 85 20 45 6 12 11 12 0 0.0620 1.000 1.000 87 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(1), JAK1(9), JAK2(8), PLA2G2A(2), PTPRU(7), REG1A(8), STAT1(13) 6688362 51 46 50 12 23 0 15 4 9 0 0.228 1.000 1.000 88 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(11), CD44(2), CSF1(4), FCGR3A(3), IL1B(3), IL6R(4), SPN(6), TGFB1(3), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFRSF8(8), TNFSF8(4) 7576664 63 47 60 15 31 0 19 4 9 0 0.0975 1.000 1.000 89 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(9), EPX(6), LPO(8), MPO(4), MTHFR(4), PRDX6(5), SHMT1(3), SHMT2(2), TPO(16) 6743191 58 49 58 16 27 3 17 5 6 0 0.199 1.000 1.000 90 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28) 9755657 77 68 77 17 34 5 16 7 15 0 0.134 1.000 1.000 91 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(6), ADRB2(3), CFTR(18), GNAS(12), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7603732 61 49 61 14 27 3 14 10 7 0 0.172 1.000 1.000 92 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(3), IARS(6), IARS2(10), ILVBL(3), LARS(11), LARS2(3), PDHA1(5), PDHA2(6), PDHB(2), VARS(5), VARS2(12) 10782385 70 59 70 12 37 3 18 3 9 0 0.0409 1.000 1.000 93 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7) 7687900 50 45 50 13 21 2 11 5 11 0 0.222 1.000 1.000 94 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 11 CARM1(6), CREBBP(50), NCOA3(16), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RARA(6) 8590303 100 82 96 23 29 4 23 9 34 1 0.207 1.000 1.000 95 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), BAD(3), CHRNB1(6), CHRNG(2), MUSK(9), PIK3R1(7), PTK2(15), PTK2B(6), RAPSN(2), SRC(5), TERT(4), YWHAH(2) 8128490 64 50 64 17 25 8 14 5 12 0 0.186 1.000 1.000 96 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(5), AKT3(8), ARHGAP5(12), BAD(3), BCAR1(6), BIRC2(3), BIRC3(3), BRAF(9), CAPN2(2), CAV2(1), CAV3(1), CCND1(4), CCND2(1), CCND3(8), CDC42(4), CHAD(3), COL11A1(30), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), COMP(8), CRK(4), CRKL(1), CTNNB1(15), DIAPH1(5), DOCK1(11), EGF(17), EGFR(7), ELK1(1), ERBB2(54), FARP2(7), FIGF(2), FLNA(14), FLNB(23), FLNC(18), FLT1(8), FN1(21), FYN(7), GRB2(3), GSK3B(5), HGF(12), IBSP(4), IGF1(2), IGF1R(11), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), JUN(4), KDR(19), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), MAP2K1(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MET(19), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), MYLPF(3), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PARVA(1), PARVB(6), PARVG(3), PDGFB(3), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PDPK1(2), PGF(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PRKCA(3), PRKCG(7), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(6), RELN(36), ROCK1(8), ROCK2(15), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SPP1(2), SRC(5), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TLN1(17), TLN2(13), TNC(19), TNN(20), TNR(12), TNXB(38), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCL(4), VEGFA(7), VEGFB(3), VEGFC(6), VTN(3), VWF(21), ZYX(4) 212409332 1738 352 1680 562 832 81 415 183 227 0 0.917 1.000 1.000 97 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY7(4), ADCY8(18), ADCY9(8), ADORA2A(1), ADORA2B(1), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), AGTR1(3), ATP2A1(9), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), ATP2B4(15), AVPR1A(4), AVPR1B(3), BDKRB1(4), BDKRB2(3), BST1(4), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(18), CACNA1H(12), CACNA1I(8), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CCKAR(3), CCKBR(9), CD38(1), CHRM1(2), CHRM2(5), CHRM3(8), CHRM5(3), CHRNA7(2), CYSLTR2(2), DRD1(2), EDNRA(4), EDNRB(8), EGFR(7), ERBB2(54), ERBB3(48), ERBB4(11), F2R(2), GNA11(3), GNA14(3), GNA15(5), GNAL(4), GNAQ(3), GNAS(12), GRIN1(9), GRIN2A(14), GRIN2C(11), GRIN2D(9), GRM1(22), GRM5(19), GRPR(1), HRH1(9), HRH2(1), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), LHCGR(7), LTB4R2(3), MYLK(15), MYLK2(7), NOS1(15), NOS3(11), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX4(2), P2RX7(5), PDE1A(8), PDE1B(4), PDE1C(15), PDGFRA(16), PDGFRB(7), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PLN(2), PPID(2), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PTAFR(1), PTGER3(5), PTGFR(7), PTK2B(6), RYR1(54), RYR2(83), RYR3(54), SLC25A4(2), SLC25A6(1), SLC8A1(8), SLC8A2(11), SLC8A3(6), SPHK1(1), SPHK2(11), TACR1(3), TACR2(1), TACR3(5), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(9), VDAC1(3), VDAC2(3) 155176749 1353 339 1298 580 629 71 359 134 158 2 0.997 1.000 1.000 98 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 196 ABI2(7), ACTN1(7), ACTN2(10), ACTN4(13), APC(29), APC2(6), ARAF(2), ARHGEF1(8), ARHGEF12(14), ARHGEF4(5), ARHGEF6(7), ARHGEF7(9), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), ARPC5(5), BAIAP2(5), BCAR1(6), BDKRB1(4), BDKRB2(3), BRAF(9), CD14(3), CDC42(4), CFL1(1), CFL2(4), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CRK(4), CRKL(1), CSK(7), CYFIP1(8), CYFIP2(9), DIAPH1(5), DIAPH3(7), DOCK1(11), EGF(17), EGFR(7), EZR(12), F2(3), F2R(2), FGD1(6), FGD3(4), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR4(6), FN1(21), GIT1(6), GNA12(3), GNA13(12), GNG12(2), GSN(2), IQGAP1(11), IQGAP2(10), IQGAP3(12), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LIMK1(6), LIMK2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MOS(2), MRAS(2), MSN(1), MYH10(24), MYH14(7), MYH9(35), MYL2(4), MYL5(2), MYLK(15), MYLK2(7), MYLPF(3), NCKAP1(12), NCKAP1L(10), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDGFB(3), PDGFRA(16), PDGFRB(7), PFN1(4), PFN2(1), PFN3(1), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP1R12B(10), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RDX(4), ROCK1(8), ROCK2(15), RRAS(2), RRAS2(2), SCIN(1), SLC9A1(7), SOS1(23), SOS2(8), SSH1(8), SSH2(18), SSH3(17), TIAM1(17), TIAM2(18), VAV1(8), VAV2(8), VAV3(7), VCL(4), WAS(4), WASF1(5), WASF2(7), WASL(2) 155508491 1256 325 1235 421 647 52 247 138 172 0 0.846 1.000 1.000 99 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(2), ACVR1C(3), AKT1(3), AKT2(5), AKT3(8), ARRB1(4), ARRB2(4), ATF2(1), ATF4(3), BDNF(3), BRAF(9), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1F(11), CACNA1G(18), CACNA1H(12), CACNA1I(8), CACNA1S(12), CACNA2D1(19), CACNA2D2(6), CACNA2D3(8), CACNA2D4(8), CACNB1(5), CACNB2(9), CACNB3(5), CACNB4(3), CACNG1(1), CACNG2(3), CACNG3(4), CACNG4(8), CACNG5(7), CACNG6(3), CACNG7(8), CACNG8(3), CASP3(3), CD14(3), CDC25B(2), CDC42(4), CHUK(7), CRK(4), CRKL(1), DAXX(9), DDIT3(1), DUSP1(3), DUSP10(4), DUSP14(4), DUSP16(6), DUSP2(2), DUSP4(3), DUSP5(1), DUSP6(7), DUSP7(4), DUSP8(6), DUSP9(3), ECSIT(4), EGF(17), EGFR(7), ELK1(1), ELK4(6), FAS(1), FASLG(1), FGF1(2), FGF10(4), FGF11(1), FGF12(5), FGF13(5), FGF14(6), FGF16(2), FGF17(1), FGF19(2), FGF23(3), FGF3(2), FGF4(1), FGF5(4), FGF6(1), FGF7(1), FGF8(3), FGF9(4), FGFR1(6), FGFR2(10), FGFR4(6), FLNA(14), FLNB(23), FLNC(18), FOS(4), GADD45A(1), GADD45G(1), GNA12(3), GNG12(2), GRB2(3), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), JUN(4), JUND(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(8), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK7(3), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MAPT(10), MEF2C(5), MKNK1(6), MKNK2(3), MOS(2), MRAS(2), MYC(2), NF1(39), NFATC2(13), NFATC4(5), NFKB1(3), NFKB2(3), NLK(6), NR4A1(2), NTF3(1), NTRK1(7), NTRK2(7), PAK1(4), PAK2(9), PDGFB(3), PDGFRA(16), PDGFRB(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PPM1A(6), PPM1B(8), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PPP5C(7), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PTPN5(2), PTPN7(1), PTPRR(8), RAC1(4), RAC2(1), RAC3(3), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(16), RASA1(8), RASA2(6), RASGRF1(12), RASGRF2(9), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KA5(9), RPS6KA6(11), RRAS(2), RRAS2(2), SOS1(23), SOS2(8), SRF(4), STK3(7), STK4(6), TAOK1(11), TAOK2(16), TAOK3(15), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF1A(5), TRAF2(5), TRAF6(1), ZAK(11) 162656857 1325 323 1311 506 631 54 287 147 202 4 0.999 1.000 1.000 100 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(20), ACTG1(11), CHAD(3), COL11A1(30), COL11A2(13), COL17A1(8), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), COMP(8), DES(2), DSC1(9), DSC2(4), DSC3(10), DSG1(12), DSG2(11), DSG3(7), DSG4(9), FN1(21), GJA1(3), GJA10(4), GJA3(3), GJA4(2), GJA5(5), GJA8(4), GJA9(6), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GJB7(1), GJC1(1), GJC3(1), GJD2(4), GJD4(4), IBSP(4), INA(2), ITGA6(9), ITGB4(15), KRT1(2), KRT10(6), KRT12(4), KRT13(4), KRT14(3), KRT15(5), KRT16(5), KRT17(1), KRT18(5), KRT19(8), KRT2(4), KRT20(7), KRT23(2), KRT24(7), KRT25(2), KRT27(4), KRT28(4), KRT3(4), KRT31(2), KRT32(3), KRT33A(3), KRT33B(9), KRT34(3), KRT35(3), KRT36(5), KRT37(1), KRT38(6), KRT39(5), KRT4(4), KRT40(4), KRT5(7), KRT6A(6), KRT6B(3), KRT6C(6), KRT7(2), KRT71(6), KRT72(3), KRT73(4), KRT74(2), KRT75(6), KRT76(5), KRT77(4), KRT78(5), KRT79(6), KRT8(6), KRT82(3), KRT83(5), KRT84(10), KRT85(3), KRT9(4), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), LMNA(5), LMNB1(4), LMNB2(7), NES(20), PRPH(4), RELN(36), SPP1(2), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VIM(7), VTN(3), VWF(21) 144100947 1150 320 1128 426 553 52 301 101 142 1 1.000 1.000 1.000 101 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(7), ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(5), ADRA1B(1), ADRA2A(3), ADRA2B(1), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), C5AR1(3), CALCR(9), CALCRL(8), CCKAR(3), CCKBR(9), CGA(2), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CNR1(4), CNR2(6), CRHR1(4), CRHR2(3), CTSG(4), CYSLTR2(2), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2(3), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHB(1), FSHR(5), GABBR1(7), GABBR2(6), GABRA1(12), GABRA2(7), GABRA3(4), GABRA4(15), GABRA5(5), GABRA6(8), GABRB1(7), GABRB2(7), GABRB3(10), GABRD(3), GABRE(6), GABRG1(9), GABRG2(5), GABRG3(6), GABRP(3), GABRQ(6), GABRR1(6), GABRR2(2), GALR1(3), GALR2(4), GALR3(3), GH1(3), GH2(4), GHR(6), GHRHR(5), GHSR(8), GIPR(3), GLP1R(3), GLP2R(3), GLRA1(6), GLRA2(4), GLRA3(5), GLRB(3), GNRHR(2), GPR156(7), GPR35(2), GPR63(3), GPR83(3), GRIA1(16), GRIA2(7), GRIA3(6), GRIA4(23), GRID1(12), GRID2(12), GRIK1(12), GRIK2(15), GRIK3(15), GRIK4(7), GRIK5(14), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), GRIN3A(5), GRIN3B(2), GRM1(22), GRM2(10), GRM3(10), GRM4(9), GRM5(19), GRM6(9), GRM7(12), GRM8(8), GRPR(1), GZMA(4), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HRH4(3), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LEP(1), LEPR(8), LHB(2), LHCGR(7), LTB4R2(3), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MCHR1(3), MCHR2(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPBWR2(4), NPFFR1(2), NPFFR2(6), NPY1R(7), NPY2R(4), NPY5R(5), NR3C1(6), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), P2RX1(3), P2RX2(8), P2RX3(4), P2RX4(2), P2RX7(5), P2RY1(3), P2RY10(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(2), P2RY8(1), PARD3(23), PRL(3), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER3(5), PTGER4(5), PTGFR(7), PTGIR(2), PTH2R(8), RXFP1(8), RXFP2(4), SCTR(4), SSTR1(3), SSTR3(4), SSTR4(6), SSTR5(1), TAAR1(3), TAAR5(2), TAAR6(3), TAAR8(4), TACR1(3), TACR2(1), TACR3(5), THRA(2), THRB(1), TRHR(9), TRPV1(3), TSHR(8), UTS2R(1), VIPR1(1), VIPR2(4) 127980841 1090 319 1080 499 449 48 320 144 128 1 0.989 1.000 1.000 102 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(12), CD36(2), CD44(2), CD47(2), CHAD(3), COL11A1(30), COL11A2(13), COL1A1(11), COL1A2(10), COL2A1(14), COL3A1(14), COL4A1(14), COL4A2(11), COL4A4(16), COL4A6(6), COL5A1(14), COL5A2(20), COL5A3(15), COL6A1(3), COL6A2(7), COL6A3(27), COL6A6(28), DAG1(3), FN1(21), FNDC1(17), FNDC3A(12), GP5(1), GP6(5), GP9(3), HMMR(2), HSPG2(33), IBSP(4), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAV(13), ITGB1(3), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), LAMA1(29), LAMA2(31), LAMA3(44), LAMA4(25), LAMA5(20), LAMB1(15), LAMB2(15), LAMB3(13), LAMB4(12), LAMC1(13), LAMC2(7), LAMC3(9), RELN(36), SDC1(5), SDC2(3), SDC3(3), SDC4(1), SPP1(2), SV2A(6), SV2B(6), SV2C(6), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNC(19), TNN(20), TNR(12), TNXB(38), VTN(3), VWF(21) 129159742 1018 315 1005 359 476 48 255 99 140 0 0.998 1.000 1.000 103 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), AKT1(3), AKT2(5), AKT3(8), AMOTL1(8), ASH1L(35), CASK(9), CDC42(4), CDK4(6), CGN(10), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTTN(10), EPB41(9), EPB41L1(8), EPB41L2(8), EPB41L3(18), EXOC3(8), EXOC4(13), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), HCLS1(5), IGSF5(4), INADL(16), JAM2(1), JAM3(4), LLGL1(4), LLGL2(6), MAGI1(15), MAGI2(17), MAGI3(16), MLLT4(15), MPDZ(20), MPP5(5), MRAS(2), MYH1(16), MYH10(24), MYH11(22), MYH13(21), MYH14(7), MYH15(22), MYH2(22), MYH3(19), MYH4(21), MYH6(14), MYH7(19), MYH7B(20), MYH8(17), MYH9(35), MYL2(4), MYL5(2), MYLPF(3), OCLN(4), PARD3(23), PARD6A(7), PARD6B(5), PARD6G(1), PPM1J(3), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PPP2R3A(14), PPP2R3B(4), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), RAB13(2), RAB3B(5), RRAS(2), RRAS2(2), SPTAN1(68), SRC(5), SYMPK(11), TJAP1(2), TJP1(9), TJP2(13), TJP3(4), VAPA(6), YES1(7), ZAK(11) 111349512 1054 310 1037 321 537 59 193 86 177 2 0.511 1.000 1.000 104 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 123 ABL1(9), ABLIM1(7), ABLIM2(4), ABLIM3(2), ARHGEF12(14), CDC42(4), CDK5(3), CFL1(1), CFL2(4), CXCL12(6), CXCR4(4), DCC(26), DPYSL2(4), DPYSL5(1), EFNA1(1), EFNA2(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB2(6), EFNB3(4), EPHA1(4), EPHA2(20), EPHA3(20), EPHA4(2), EPHA5(23), EPHA6(14), EPHA7(12), EPHA8(10), EPHB1(14), EPHB2(10), EPHB3(12), EPHB4(7), EPHB6(11), FES(3), FYN(7), GNAI1(4), GNAI2(5), GNAI3(6), GSK3B(5), ITGB1(3), L1CAM(8), LIMK1(6), LIMK2(5), LRRC4C(8), MAPK3(8), MET(19), NCK1(2), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NGEF(6), NRP1(8), NTN1(5), NTN4(4), NTNG1(6), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PLXNA1(8), PLXNA2(17), PLXNA3(7), PLXNB1(13), PLXNB2(23), PLXNB3(10), PLXNC1(9), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PTK2(15), RAC1(4), RAC2(1), RAC3(3), RASA1(8), RGS3(4), RND1(4), ROBO1(17), ROBO2(22), ROBO3(6), ROCK1(8), ROCK2(15), SEMA3A(11), SEMA3C(9), SEMA3D(18), SEMA3E(13), SEMA3F(6), SEMA3G(8), SEMA4A(9), SEMA4B(6), SEMA4C(5), SEMA4D(3), SEMA4F(3), SEMA4G(6), SEMA5A(7), SEMA5B(16), SEMA6A(5), SEMA6B(6), SEMA6C(8), SEMA6D(12), SEMA7A(3), SLIT1(9), SLIT2(17), SLIT3(11), SRGAP1(7), SRGAP2(10), SRGAP3(7), UNC5A(5), UNC5B(10), UNC5C(17), UNC5D(10) 112697994 958 308 951 321 421 47 258 108 122 2 0.741 1.000 1.000 105 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRB1(3), ADRB2(3), ANXA6(6), ARRB1(4), ARRB2(4), ATP1A4(11), ATP1B1(1), ATP1B2(5), ATP1B3(2), ATP2A2(10), ATP2A3(5), ATP2B1(11), ATP2B2(13), ATP2B3(3), CACNA1A(25), CACNA1B(20), CACNA1C(14), CACNA1D(18), CACNA1E(18), CACNA1S(12), CACNB1(5), CACNB3(5), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CASQ1(7), CASQ2(5), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), GJA1(3), GJA4(2), GJA5(5), GJB2(2), GJB3(3), GJB5(4), GJB6(2), GNA11(3), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), ITPR1(21), ITPR2(33), ITPR3(9), KCNB1(8), KCNJ3(4), KCNJ5(2), MIB1(9), NME7(3), PEA15(2), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLN(2), PRKACA(2), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(4), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RYR1(54), RYR2(83), RYR3(54), SFN(1), SLC8A1(8), SLC8A3(6), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3) 108011816 921 297 907 420 422 47 221 97 133 1 1.000 1.000 1.000 106 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(7), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADM(3), ARRB1(4), ARRB2(4), ATF1(2), ATF2(1), ATF4(3), ATP2A2(10), ATP2A3(5), CACNB3(5), CALCA(1), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CNN1(3), CNN2(4), CORIN(7), CREB3(5), CRHR1(4), DGKZ(3), ETS2(5), FOS(4), GABPA(6), GABPB2(2), GBA2(1), GJA1(3), GNAQ(3), GNB1(7), GNB3(5), GNB4(5), GNB5(2), GNG12(2), GNG2(1), GNG3(3), GNG4(5), GNG5(1), GRK4(2), GRK5(5), GRK6(4), GSTO1(2), GUCY1A3(12), IGFBP1(4), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(3), IL6(4), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), MIB1(9), MYL2(4), MYLK2(7), NFKB1(3), NOS1(15), NOS3(11), OXT(1), OXTR(1), PDE4B(7), PDE4D(4), PKIA(2), PKIB(1), PKIG(3), PLCB3(11), PLCD1(6), PLCG1(12), PLCG2(6), PRKACA(2), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), RAMP1(2), RAMP2(1), RAMP3(2), RGS1(1), RGS10(4), RGS11(1), RGS14(5), RGS16(4), RGS17(1), RGS18(6), RGS19(3), RGS2(1), RGS20(3), RGS3(4), RGS4(2), RGS5(3), RGS6(5), RGS7(8), RGS9(6), RLN1(2), RYR1(54), RYR2(83), RYR3(54), SFN(1), SLC8A1(8), SP1(10), TNXB(38), USP5(3), YWHAB(2), YWHAH(2), YWHAQ(3) 99781943 853 293 839 356 403 42 198 83 125 2 0.998 1.000 1.000 107 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(5), CADM1(6), CADM3(4), CD2(2), CD22(4), CD226(5), CD274(5), CD276(1), CD28(4), CD34(3), CD4(3), CD40(5), CD40LG(2), CD58(1), CD6(3), CD80(2), CD86(6), CD8A(2), CD99(4), CDH1(15), CDH15(8), CDH2(14), CDH3(7), CDH4(18), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CNTN1(11), CNTN2(9), CNTNAP1(12), CNTNAP2(25), CTLA4(1), ESAM(1), F11R(5), GLG1(9), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(3), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), ICAM1(7), ICAM2(1), ICAM3(5), ICOS(2), ICOSLG(3), ITGA4(19), ITGA6(9), ITGA8(20), ITGA9(9), ITGAL(17), ITGAM(13), ITGAV(13), ITGB1(3), ITGB2(7), ITGB7(3), ITGB8(11), JAM2(1), JAM3(4), L1CAM(8), MADCAM1(1), MAG(4), MPZ(5), MPZL1(3), NCAM1(9), NCAM2(16), NEGR1(2), NEO1(12), NFASC(11), NLGN1(11), NLGN2(3), NLGN3(6), NRCAM(16), NRXN1(25), NRXN2(11), NRXN3(10), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(19), PTPRF(14), PTPRM(17), PVR(4), PVRL1(10), PVRL2(5), PVRL3(5), SDC1(5), SDC2(3), SDC3(3), SDC4(1), SELE(7), SELP(7), SELPLG(3), SIGLEC1(12), SPN(6), VCAM1(14), VCAN(37) 85441016 787 291 774 264 356 43 176 95 115 2 0.674 1.000 1.000 108 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(7), ACVR1B(2), ACVR2A(3), ACVR2B(2), AMHR2(2), BMP2(1), BMP7(4), BMPR1A(3), BMPR1B(5), BMPR2(9), CCL1(3), CCL13(2), CCL14(2), CCL15(1), CCL16(1), CCL17(1), CCL2(1), CCL21(2), CCL22(2), CCL23(1), CCL25(2), CCL26(1), CCL27(1), CCL28(1), CCL3(2), CCL5(1), CCL7(3), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CCR9(1), CD27(6), CD40(5), CD40LG(2), CD70(1), CLCF1(3), CNTF(5), CNTFR(1), CRLF2(2), CSF1(4), CSF1R(11), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(5), CX3CL1(9), CX3CR1(4), CXCL1(1), CXCL10(2), CXCL11(1), CXCL12(6), CXCL13(2), CXCL14(2), CXCL16(1), CXCL2(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(3), CXCR4(4), CXCR6(4), EDA(6), EDA2R(1), EDAR(4), EGF(17), EGFR(7), EPO(2), EPOR(5), FAS(1), FASLG(1), FLT1(8), FLT3(10), FLT3LG(1), FLT4(10), GDF5(2), GH1(3), GH2(4), GHR(6), HGF(12), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(9), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17B(3), IL17RA(4), IL17RB(2), IL18R1(4), IL18RAP(9), IL19(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL1RAP(5), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), INHBA(3), INHBB(3), INHBC(1), INHBE(6), KDR(19), KIT(9), KITLG(5), LEP(1), LEPR(8), LIF(2), LIFR(9), LTA(1), LTB(3), LTBR(3), MET(19), MPL(7), NGFR(4), OSM(5), OSMR(9), PDGFB(3), PDGFC(5), PDGFRA(16), PDGFRB(7), PF4V1(2), PLEKHO2(5), PPBP(2), PRL(3), PRLR(4), RELT(1), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF11A(1), TNFRSF11B(3), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(3), TNFRSF14(2), TNFRSF17(2), TNFRSF18(2), TNFRSF19(3), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(8), TNFRSF9(2), TNFSF10(5), TNFSF11(1), TNFSF13(2), TNFSF13B(5), TNFSF14(1), TNFSF18(4), TNFSF4(1), TNFSF8(4), TNFSF9(2), TPO(16), TSLP(3), VEGFA(7), VEGFB(3), VEGFC(6), XCL2(1) 102687070 814 287 809 268 374 30 184 96 128 2 0.465 1.000 1.000 109 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(29), APC2(6), AXIN1(4), AXIN2(19), BTRC(4), CACYBP(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CCND1(4), CCND2(1), CCND3(8), CER1(4), CHD8(18), CREBBP(50), CSNK1A1(6), CSNK1A1L(4), CSNK1E(3), CSNK2A1(11), CSNK2B(5), CTBP1(6), CTBP2(10), CTNNB1(15), CTNNBIP1(1), CUL1(19), CXXC4(1), DAAM1(10), DAAM2(9), DKK1(2), DKK2(5), DKK4(2), DVL1(5), DVL2(9), DVL3(4), FBXW11(1), FOSL1(3), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(5), JUN(4), LEF1(4), LRP5(8), LRP6(15), MAP3K7(8), MAPK10(9), MAPK8(5), MAPK9(5), MMP7(1), MYC(2), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NKD1(3), NKD2(1), NLK(6), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PORCN(2), PPARD(6), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRICKLE1(7), PRICKLE2(7), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), PSEN1(8), RAC1(4), RAC2(1), RAC3(3), RBX1(1), ROCK1(8), ROCK2(15), RUVBL1(7), SENP2(1), SFRP1(2), SFRP2(4), SFRP4(5), SIAH1(3), SKP1(7), SMAD2(5), SMAD3(6), SMAD4(8), SOX17(3), TBL1X(5), TBL1XR1(8), TBL1Y(3), TCF7(3), TCF7L2(1), VANGL1(5), VANGL2(3), WIF1(6), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2) 89944808 785 283 765 272 385 38 160 75 126 1 0.952 1.000 1.000 110 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(7), ACTN2(10), ACTN4(13), DES(2), DMD(41), MYBPC1(17), MYBPC2(8), MYBPC3(5), MYH3(19), MYH6(14), MYH7(19), MYH8(17), MYL2(4), MYOM1(17), NEB(54), TCAP(1), TMOD1(4), TNNC2(1), TNNI1(5), TNNI2(2), TNNI3(1), TNNT1(7), TNNT2(1), TNNT3(1), TPM1(3), TPM2(2), TPM3(1), TPM4(3), TTN(389), VIM(7) 78391260 679 279 674 206 326 30 154 98 65 6 0.894 1.000 1.000 111 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADK(3), ADSL(4), ADSS(4), ADSSL1(4), AK1(1), AK2(3), AK5(3), AK7(7), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), CANT1(1), DCK(6), DGUOK(1), ENPP1(7), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), FHIT(4), GART(7), GDA(7), GMPR(2), GMPR2(4), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(9), ITPA(1), NME1(1), NME2(3), NME4(1), NME6(1), NME7(3), NPR1(8), NPR2(6), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT5(3), NUDT9(4), PAICS(4), PAPSS1(4), PAPSS2(2), PDE10A(8), PDE11A(19), PDE1A(8), PDE1C(15), PDE2A(2), PDE3B(9), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE5A(11), PDE6H(1), PDE7A(4), PDE7B(2), PDE8A(4), PDE8B(4), PDE9A(7), PFAS(7), PKLR(8), PNPT1(10), POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PPAT(4), PRIM2(1), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RFC5(5), RRM1(4), RRM2(4), RRM2B(2), XDH(11) 94682952 719 275 707 265 366 37 155 62 97 2 0.971 1.000 1.000 112 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACP1(2), ACTB(20), ACTG1(11), ACTN1(7), ACTN2(10), ACTN4(13), ACVR1B(2), ACVR1C(3), BAIAP2(5), CDC42(4), CDH1(15), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTNND1(10), EGFR(7), ERBB2(54), FARP2(7), FER(12), FGFR1(6), FYN(7), IGF1R(11), INSR(10), IQGAP1(11), LEF1(4), LMO7(13), MAP3K7(8), MAPK3(8), MET(19), MLLT4(15), NLK(6), PARD3(23), PTPN1(5), PTPN6(2), PTPRB(17), PTPRF(14), PTPRJ(8), PTPRM(17), PVRL1(10), PVRL2(5), PVRL3(5), PVRL4(4), RAC1(4), RAC2(1), RAC3(3), SMAD2(5), SMAD3(6), SMAD4(8), SNAI1(4), SNAI2(3), SORBS1(10), SRC(5), SSX2IP(3), TCF7(3), TCF7L2(1), TGFBR1(7), TGFBR2(8), TJP1(9), VCL(4), WAS(4), WASF1(5), WASF2(7), WASF3(5), WASL(2), YES1(7) 66565863 644 272 596 175 305 32 127 66 110 4 0.174 1.000 1.000 113 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT1(3), AKT2(5), AKT3(8), BCL2L1(4), CBL(8), CBLB(13), CBLC(3), CCND1(4), CCND2(1), CCND3(8), CISH(1), CLCF1(3), CNTF(5), CNTFR(1), CREBBP(50), CRLF2(2), CSF2RA(7), CSF2RB(5), CSF3(1), CSF3R(5), EPO(2), EPOR(5), GH1(3), GH2(4), GHR(6), GRB2(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IFNK(4), IFNW1(2), IL10(1), IL10RA(9), IL10RB(9), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL13RA1(2), IL15(1), IL15RA(1), IL19(2), IL2(1), IL20(1), IL20RA(6), IL21(3), IL21R(8), IL22(1), IL22RA1(4), IL22RA2(3), IL23A(1), IL23R(4), IL24(2), IL26(1), IL2RA(1), IL2RB(2), IL2RG(5), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL6ST(9), IL7(1), IL7R(7), IL9R(3), IRF9(6), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), LIF(2), LIFR(9), MPL(7), MYC(2), OSM(5), OSMR(9), PIAS1(3), PIAS2(1), PIAS3(6), PIAS4(4), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIM1(1), PRL(3), PRLR(4), PTPN11(4), PTPN6(2), SOCS3(1), SOCS4(1), SOCS5(3), SOCS7(5), SOS1(23), SOS2(8), SPRED1(4), SPRED2(6), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(5), STAM(4), STAM2(6), STAT1(13), STAT2(4), STAT3(6), STAT4(9), STAT5A(1), STAT5B(5), STAT6(9), TPO(16), TSLP(3), TYK2(9) 80227130 632 271 621 184 290 21 131 68 119 3 0.264 1.000 1.000 114 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ADRB1(3), CSNK1D(3), DRD1(2), DRD2(5), EGF(17), EGFR(7), GJA1(3), GJD2(4), GNA11(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAQ(3), GNAS(12), GRB2(3), GRM1(22), GRM5(19), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), HTR2A(2), HTR2B(5), HTR2C(1), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAP2K2(5), MAP2K5(4), MAP3K2(6), MAPK3(8), MAPK7(3), NPR1(8), NPR2(6), PDGFB(3), PDGFC(5), PDGFD(8), PDGFRA(16), PDGFRB(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKG1(10), PRKG2(8), PRKX(1), RAF1(4), SOS1(23), SOS2(8), SRC(5), TJP1(9), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4) 76100550 624 269 611 237 304 29 152 66 73 0 0.903 1.000 1.000 115 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(9), ANAPC1(17), ANAPC11(1), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), ATM(65), ATR(32), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNH(4), CDC14A(5), CDC14B(10), CDC16(4), CDC20(4), CDC23(1), CDC25A(5), CDC25B(2), CDC25C(2), CDC27(13), CDC6(9), CDC7(4), CDK2(1), CDK4(6), CDK6(5), CDK7(6), CDKN1B(6), CDKN2B(3), CDKN2C(2), CDKN2D(1), CHEK1(3), CHEK2(11), CREBBP(50), CUL1(19), DBF4(11), E2F1(3), E2F2(4), E2F3(5), ESPL1(17), FZR1(5), GADD45A(1), GADD45G(1), GSK3B(5), HDAC1(4), HDAC2(3), MAD1L1(4), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), PCNA(4), PKMYT1(2), PLK1(5), PRKDC(35), PTTG1(2), RBL1(9), RBL2(9), RBX1(1), SFN(1), SKP1(7), SKP2(5), SMAD2(5), SMAD3(6), SMAD4(8), SMC1A(16), SMC1B(9), TFDP1(2), TGFB1(3), TGFB3(1), WEE1(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 73876156 684 266 663 161 343 27 105 72 131 6 0.0454 1.000 1.000 116 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 126 ACACA(28), ACACB(21), AKT1(3), AKT2(5), AKT3(8), ARAF(2), BAD(3), BRAF(9), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CBL(8), CBLB(13), CBLC(3), CRK(4), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(8), FASN(12), FBP1(3), FBP2(2), FLOT1(4), FLOT2(5), FOXO1(2), G6PC(2), G6PC2(2), GCK(1), GRB2(3), GSK3B(5), GYS1(12), GYS2(13), IKBKB(11), INPP5D(5), INSR(10), IRS1(9), IRS2(5), IRS4(18), LIPE(14), MAP2K1(3), MAP2K2(5), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MKNK1(6), MKNK2(3), PCK1(9), PCK2(2), PDE3A(11), PDE3B(9), PDPK1(2), PFKL(2), PFKM(5), PFKP(4), PHKA1(14), PHKA2(8), PHKB(10), PHKG1(3), PHKG2(3), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PKLR(8), PPARGC1A(18), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R3A(18), PPP1R3B(3), PPP1R3C(4), PPP1R3D(3), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACA(2), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCI(8), PRKCZ(4), PRKX(1), PTPN1(5), PTPRF(14), PYGB(8), PYGL(4), PYGM(13), RAF1(4), RAPGEF1(6), RHEB(4), RHOQ(1), RPS6(5), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SLC2A4(4), SOCS3(1), SOCS4(1), SORBS1(10), SOS1(23), SOS2(8), SREBF1(6), TRIP10(6), TSC2(11) 89245832 721 266 713 266 373 25 147 77 98 1 0.976 1.000 1.000 117 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 80 ABL1(9), ABL2(7), AKT1(3), AKT2(5), AKT3(8), ARAF(2), AREG(2), BAD(3), BRAF(9), BTC(1), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CBL(8), CBLB(13), CBLC(3), CDKN1B(6), CRK(4), CRKL(1), EGF(17), EGFR(7), EIF4EBP1(1), ELK1(1), ERBB2(54), ERBB3(48), ERBB4(11), EREG(1), GAB1(7), GRB2(3), GSK3B(5), HBEGF(1), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK9(5), MYC(2), NCK1(2), NCK2(5), NRG1(18), NRG2(3), NRG3(8), NRG4(1), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(7), PTK2(15), RAF1(4), RPS6KB1(4), RPS6KB2(1), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SRC(5), STAT5A(1), STAT5B(5) 57454608 537 265 492 173 271 32 118 52 63 1 0.738 1.000 1.000 118 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(2), BRAF(9), CACNA1A(25), CRHR1(4), GNA11(3), GNA12(3), GNA13(12), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAS(12), GNAZ(3), GRIA1(16), GRIA2(7), GRIA3(6), GRID2(12), GRM1(22), GRM5(19), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), IGF1(2), IGF1R(11), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP2K1(3), MAP2K2(5), MAPK3(8), NOS1(15), NOS3(11), NPR1(8), NPR2(6), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), PRKCA(3), PRKCG(7), PRKG1(10), PRKG2(8), RAF1(4), RYR1(54) 63062654 554 258 542 210 275 23 133 61 61 1 0.920 1.000 1.000 119 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(7), ACTN2(10), ACTN4(13), ARHGAP5(12), BCAR1(6), CD99(4), CDC42(4), CDH5(9), CLDN1(3), CLDN10(3), CLDN11(1), CLDN14(3), CLDN15(2), CLDN16(3), CLDN17(3), CLDN18(2), CLDN19(1), CLDN2(2), CLDN22(2), CLDN23(1), CLDN3(1), CLDN4(3), CLDN5(3), CLDN6(1), CLDN7(1), CLDN8(2), CLDN9(1), CTNNA1(6), CTNNA2(22), CTNNA3(11), CTNNB1(15), CTNND1(10), CXCL12(6), CXCR4(4), CYBA(2), CYBB(1), ESAM(1), EZR(12), F11R(5), GNAI1(4), GNAI2(5), GNAI3(6), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), ITK(6), JAM2(1), JAM3(4), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MLLT4(15), MMP2(7), MMP9(6), MSN(1), MYL2(4), MYL5(2), MYLPF(3), NCF1(1), NCF2(6), NCF4(3), NOX1(4), NOX3(5), OCLN(4), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PRKCA(3), PRKCG(7), PTK2(15), PTK2B(6), PTPN11(4), PXN(3), RAC1(4), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(9), RASSF5(2), RHOH(3), ROCK1(8), ROCK2(15), SIPA1(5), THY1(3), TXK(10), VASP(1), VAV1(8), VAV2(8), VAV3(7), VCAM1(14), VCL(4) 70412548 578 252 569 176 276 27 129 65 81 0 0.306 1.000 1.000 120 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(8), BCAR1(6), CAPN1(5), CAPN10(2), CAPN11(2), CAPN2(2), CAPN3(7), CAPN5(4), CAPN6(3), CAPN7(4), CAPN9(6), CAV2(1), CAV3(1), CDC42(4), CRK(4), CSK(7), DOCK1(11), FYN(7), GIT2(6), GRB2(3), ILK(3), ITGA10(9), ITGA11(13), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGAD(4), ITGAE(11), ITGAL(17), ITGAM(13), ITGAV(13), ITGAX(3), ITGB1(3), ITGB2(7), ITGB3(9), ITGB4(15), ITGB5(2), ITGB6(11), ITGB7(3), ITGB8(11), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAPK10(9), MAPK12(2), MAPK4(5), MAPK6(4), MAPK7(3), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PDPK1(2), PIK3R2(4), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(8), ROCK2(15), SDCCAG8(8), SEPP1(4), SHC1(8), SHC3(1), SORBS1(10), SOS1(23), SRC(5), TLN1(17), TNS1(20), VASP(1), VAV2(8), VAV3(7), VCL(4), ZYX(4) 77266507 605 249 601 205 295 27 130 80 73 0 0.820 1.000 1.000 121 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 95 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ASIP(1), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CREB3(5), CREB3L2(5), CREB3L3(8), CREB3L4(7), CREBBP(50), CTNNB1(15), DCT(9), DVL1(5), DVL2(9), DVL3(4), EDN1(2), EDNRB(8), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD4(2), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GNAI1(4), GNAI2(5), GNAI3(6), GNAO1(3), GNAQ(3), GNAS(12), GSK3B(5), KIT(9), KITLG(5), LEF1(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MC1R(2), MITF(8), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), POMC(1), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), RAF1(4), TCF7(3), TCF7L2(1), TYR(12), TYRP1(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2) 59449567 514 248 500 214 235 24 129 53 72 1 0.974 1.000 1.000 122 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 63 ADCY1(6), ADCY8(18), ARAF(2), ATF4(3), BRAF(9), CACNA1C(14), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CREBBP(50), GNAQ(3), GRIA1(16), GRIA2(7), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), GRM1(22), GRM5(19), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAP2K2(5), MAPK3(8), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PPP1CA(8), PPP1CB(4), PPP1CC(2), PPP1R12A(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCG(7), PRKX(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11) 53885670 485 242 474 190 215 27 111 58 73 1 0.964 1.000 1.000 123 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 92 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), ATF4(3), CACNA1C(14), CACNA1D(18), CACNA1F(11), CACNA1S(12), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDC42(4), CGA(2), EGFR(7), ELK1(1), FSHB(1), GNA11(3), GNAQ(3), GNAS(12), GNRH1(3), GNRHR(2), GRB2(3), HBEGF(1), ITPR1(21), ITPR2(33), ITPR3(9), JUN(4), LHB(2), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK7(3), MAPK8(5), MAPK9(5), MMP14(4), MMP2(7), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLD1(9), PLD2(3), PRKACA(2), PRKACB(4), PRKACG(2), PRKCA(3), PRKCD(8), PRKX(1), PTK2B(6), RAF1(4), SOS1(23), SOS2(8), SRC(5) 72692980 554 242 542 263 267 24 126 61 76 0 1.000 1.000 1.000 124 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(4), ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADK(3), ADSL(4), ADSS(4), AK1(1), AK2(3), AK5(3), ALLC(3), AMPD1(10), AMPD2(6), AMPD3(4), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), CANT1(1), DCK(6), DGUOK(1), ENPP1(7), ENPP3(6), ENTPD1(1), ENTPD2(2), FHIT(4), GART(7), GDA(7), GMPS(5), GUCY1A2(11), GUCY1A3(12), GUCY1B3(9), GUCY2C(14), GUCY2D(6), GUCY2F(10), GUK1(3), HPRT1(1), IMPDH1(1), IMPDH2(9), ITPA(1), NME1(1), NME2(3), NPR1(8), NPR2(6), NT5C(1), NT5E(6), PAICS(4), PAPSS1(4), PAPSS2(2), PDE1A(8), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE5A(11), PDE6B(5), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(7), PFAS(7), PKLR(8), POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), PPAT(4), PRPS1(3), PRPS1L1(4), PRPS2(1), PRUNE(8), RRM1(4), RRM2(4) 74370900 566 242 557 212 269 31 129 54 81 2 0.960 1.000 1.000 125 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(4), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(3), AGTR2(4), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(9), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CCR9(1), CCRL2(4), CHML(6), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CNR2(6), CX3CR1(4), CXCR3(3), CXCR4(4), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), EDNRA(4), EDNRB(8), F2R(2), F2RL1(5), F2RL2(2), F2RL3(2), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(8), GNB2L1(3), GPR17(3), GPR173(2), GPR174(4), GPR27(1), GPR35(2), GPR37(6), GPR37L1(5), GPR4(4), GPR6(5), GPR63(3), GPR83(3), GPR85(4), GPR87(3), GRPR(1), HCRTR1(1), HCRTR2(10), HRH1(9), HRH2(1), HRH3(4), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5), LHCGR(7), MAS1(2), MC1R(2), MC3R(4), MC4R(3), MC5R(3), MLNR(3), MTNR1A(4), MTNR1B(1), NMBR(6), NMUR2(1), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(5), OPRK1(4), OPRL1(2), OR10A5(2), OR11A1(4), OR12D3(1), OR1C1(2), OR1F1(2), OR1Q1(2), OR2H1(3), OR5V1(5), OR7A5(6), OR7C1(6), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(2), P2RY12(2), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(2), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), RGR(3), RHO(3), RRH(4), SSTR1(3), SSTR3(4), SSTR4(6), SUCNR1(3), TRHR(9) 69978476 533 241 529 301 220 26 160 71 56 0 0.997 1.000 1.000 126 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(13), ABCA10(9), ABCA12(31), ABCA13(45), ABCA2(11), ABCA3(8), ABCA4(15), ABCA5(10), ABCA6(20), ABCA7(11), ABCA8(19), ABCA9(17), ABCB1(16), ABCB10(6), ABCB11(4), ABCB4(11), ABCB5(24), ABCB6(6), ABCB7(5), ABCB8(10), ABCB9(1), ABCC1(10), ABCC10(10), ABCC11(14), ABCC12(14), ABCC2(12), ABCC3(16), ABCC4(11), ABCC5(25), ABCC6(6), ABCC8(10), ABCC9(16), ABCD1(5), ABCD2(9), ABCD3(9), ABCD4(2), ABCG1(5), ABCG2(10), ABCG4(7), ABCG5(4), ABCG8(3), CFTR(18), TAP1(3), TAP2(2) 68236069 513 241 509 166 241 29 99 60 82 2 0.113 1.000 1.000 127 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(2), BID(2), BRAF(9), CASP3(3), CD244(6), CD247(1), CD48(1), FAS(1), FASLG(1), FCER1G(1), FCGR3A(3), FCGR3B(8), FYN(7), GRB2(3), GZMB(2), HCST(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-E(5), HLA-G(3), ICAM1(7), ICAM2(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), ITGAL(17), ITGB2(7), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL1(7), KIR3DL2(1), KLRC2(3), KLRC3(3), KLRD1(1), KLRK1(2), LAT(1), LCK(2), LCP2(5), MAP2K1(3), MAP2K2(5), MAPK3(8), MICA(2), MICB(3), NCR1(4), NCR2(4), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PAK1(4), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRF1(7), PRKCA(3), PRKCG(7), PTK2B(6), PTPN11(4), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D1A(1), SH2D1B(3), SH3BP2(2), SHC1(8), SHC2(3), SHC3(1), SHC4(5), SOS1(23), SOS2(8), SYK(8), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFSF10(5), TYROBP(1), ULBP1(2), ULBP3(2), VAV1(8), VAV2(8), VAV3(7), ZAP70(3) 63699535 513 237 507 185 254 20 108 53 77 1 0.913 1.000 1.000 128 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(9), ACTN1(7), ACTR2(3), ACTR3(2), AKT1(3), AKT2(5), AKT3(8), ANGPTL2(3), ARHGEF6(7), ARHGEF7(9), BCAR1(6), BRAF(9), CDC42(4), CRK(4), CSE1L(12), DOCK1(11), EPHB2(10), FYN(7), GRB2(3), GRB7(1), ILK(3), ITGA1(7), ITGA10(9), ITGA11(13), ITGA2(6), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGA7(8), ITGA8(20), ITGA9(9), ITGB3BP(2), MAP2K4(4), MAP2K7(3), MAP3K11(5), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MRAS(2), MYLK(15), MYLK2(7), P4HB(6), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PIK3CB(11), PKLR(8), PLCG1(12), PLCG2(6), PTK2(15), RAF1(4), RALA(2), RHO(3), ROCK1(8), ROCK2(15), SHC1(8), SOS1(23), SOS2(8), SRC(5), TERF2IP(4), TLN1(17), TLN2(13), VASP(1), WAS(4), ZYX(4) 68727493 530 235 525 156 264 25 101 70 69 1 0.362 1.000 1.000 129 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 88 ADCY1(6), ADCY2(21), ADCY3(5), ADCY4(7), ADCY5(13), ADCY6(15), ADCY7(4), ADCY8(18), ADCY9(8), AKAP1(8), AKAP10(6), AKAP11(15), AKAP12(11), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(29), AKAP7(3), AKAP8(3), AKAP9(49), ARHGEF1(8), CALM1(2), CALM2(2), CHMP1B(3), GNA11(3), GNA12(3), GNA13(12), GNA14(3), GNA15(5), GNAI2(5), GNAI3(6), GNAL(4), GNAO1(3), GNAQ(3), GNAZ(3), GNB1(7), GNB3(5), GNB5(2), GNG12(2), GNG3(3), GNG4(5), GNG5(1), GNGT2(1), IL18BP(2), ITPR1(21), KCNJ3(4), PALM2(3), PDE1A(8), PDE1B(4), PDE1C(15), PDE4A(13), PDE4B(7), PDE4C(8), PDE4D(4), PDE7A(4), PDE7B(2), PDE8A(4), PDE8B(4), PLCB3(11), PPP3CA(7), PPP3CC(4), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKD3(13), RRAS(2), SLC9A1(7), USP5(3) 66992226 561 234 543 198 293 28 100 62 77 1 0.929 1.000 1.000 130 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM1(2), CALM2(2), CALML3(1), CALML6(3), CDIPT(3), CDS1(5), CDS2(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(11), ITPK1(4), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), OCRL(4), PI4KA(11), PI4KB(13), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3C3(11), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PRKCA(3), PRKCG(7), PTPMT1(3), SYNJ1(20), SYNJ2(8) 70218166 531 234 525 199 274 23 114 48 72 0 0.955 1.000 1.000 131 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(19), AMY2A(3), AMY2B(9), ASCC3(24), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(5), DHX58(3), ENPP1(7), ENPP3(6), ENTPD7(5), EP400(23), ERCC3(7), G6PC(2), G6PC2(2), GAA(5), GANC(7), GBA(4), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), IFIH1(8), LYZL1(1), MGAM(16), MOV10L1(7), NUDT5(3), PGM1(3), PGM3(2), PYGB(8), PYGL(4), PYGM(13), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SI(23), SKIV2L2(9), SMARCA2(24), SMARCA5(4), TREH(5), UGDH(5), UGP2(9), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UXS1(3) 71032113 545 232 537 185 259 33 111 70 72 0 0.951 1.000 1.000 132 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(7), ACVR1B(2), ACVR1C(3), ACVR2A(3), ACVR2B(2), ACVRL1(5), AMHR2(2), BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BMPR1A(3), BMPR1B(5), BMPR2(9), CDKN2B(3), CHRD(8), COMP(8), CREBBP(50), CUL1(19), DCN(3), E2F4(2), E2F5(3), FST(4), GDF5(2), GDF6(4), ID1(7), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(3), INHBC(1), INHBE(6), LEFTY2(2), LTBP1(20), MAPK3(8), MYC(2), NODAL(3), NOG(2), PITX2(7), PPP2CA(2), PPP2CB(2), PPP2R1A(4), PPP2R1B(6), PPP2R2A(3), PPP2R2B(4), PPP2R2C(4), RBL1(9), RBL2(9), RBX1(1), ROCK1(8), ROCK2(15), RPS6KB1(4), RPS6KB2(1), SKP1(7), SMAD1(6), SMAD2(5), SMAD3(6), SMAD4(8), SMAD6(2), SMAD7(3), SMAD9(3), SMURF1(8), SMURF2(8), SP1(10), TFDP1(2), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), THBS1(8), THBS2(14), THBS3(5), THBS4(4), TNF(4), ZFYVE16(14), ZFYVE9(26) 54384541 469 231 456 154 203 19 111 44 89 3 0.922 1.000 1.000 133 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(7), ACVR1B(2), ACVRL1(5), AKT1(3), AURKB(2), BMPR1A(3), BMPR2(9), BUB1(18), CDIPT(3), CDKL1(2), CDKL2(5), CDS1(5), CDS2(3), CLK1(7), CLK2(10), CLK4(3), COL4A3BP(8), CSNK2A1(11), CSNK2B(5), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MAP3K10(2), MOS(2), NEK1(5), NEK3(4), OCRL(4), PAK4(1), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CB(11), PIK3CG(10), PIM2(3), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCG1(12), PLCG2(6), PLK3(10), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), PRKCZ(4), PRKD1(12), PRKG1(10), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KB1(4), TGFBR1(7), VRK1(3) 63855258 527 228 522 186 257 31 96 62 79 2 0.933 1.000 1.000 134 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(3), ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(5), ALG3(2), ALG6(3), ALG8(2), ALG9(3), B3GNT1(3), B3GNT2(5), B3GNT6(1), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT7(1), C1GALT1(4), C1GALT1C1(3), CHPF(4), CHST1(2), CHST11(2), CHST12(3), CHST14(3), CHST2(1), CHST4(3), CHST6(1), CHST7(2), CHSY1(9), DDOST(1), DPAGT1(6), EXT1(10), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), FUT11(2), FUT8(7), GALNT1(5), GALNT10(3), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(8), GALNT3(5), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GANAB(16), GCNT1(5), GCNT3(3), GCNT4(5), HS2ST1(4), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), MGAT5B(7), NDST1(2), NDST2(2), NDST3(7), NDST4(13), OGT(5), RPN1(3), RPN2(5), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(8), STT3B(5), UST(4), WBSCR17(9), XYLT1(6), XYLT2(6) 63726999 430 227 425 183 215 22 86 57 49 1 0.994 1.000 1.000 135 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 89 ACTB(20), BAD(3), CABIN1(10), CALM1(2), CALM2(2), CAMK2B(5), CAMK4(4), CD3E(2), CD3G(2), CEBPB(3), CNR1(4), CREBBP(50), CSNK2A1(11), CSNK2B(5), CTLA4(1), EGR2(3), EGR3(3), FCER1A(5), FCGR3A(3), FOS(4), FOSL1(3), GATA3(8), GATA4(1), GSK3A(2), GSK3B(5), ICOS(2), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL1B(3), IL2(1), IL2RA(1), IL6(4), ITK(6), JUNB(5), KPNA5(5), MAP2K7(3), MAPK14(3), MAPK8(5), MAPK9(5), MEF2A(7), MEF2B(3), MEF2D(3), MYF5(9), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB2(3), NFKBIB(6), NFKBIE(7), NPPB(1), NUP214(17), OPRD1(5), P2RX7(5), PAK1(4), PPIA(1), PPP3CB(7), PPP3CC(4), PPP3R1(1), PTPRC(19), RELA(6), SFN(1), SLA(2), SP1(10), SP3(3), TGFB1(3), TNF(4), TRAF2(5), TRPV6(5), VAV1(8), VAV2(8), VAV3(7), XPO5(10) 49500717 449 221 441 144 201 20 95 38 94 1 0.688 1.000 1.000 136 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 77 ABL1(9), ATM(65), BUB1(18), BUB1B(11), BUB3(3), CCNA1(4), CCNA2(3), CCNB1(5), CCNB3(9), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNH(4), CDAN1(6), CDC14A(5), CDC14B(10), CDC20(4), CDC25A(5), CDC25B(2), CDC25C(2), CDC6(9), CDC7(4), CDH1(15), CDK2(1), CDK4(6), CHEK1(3), CHEK2(11), DTX4(3), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), ESPL1(17), GADD45A(1), GSK3B(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), HDAC8(4), MAD1L1(4), MAD2L1(3), MAD2L2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MPEG1(12), MPL(7), PCNA(4), PLK1(5), PRKDC(35), PTPRA(2), PTTG1(2), RBL1(9), SKP2(5), SMAD4(8), TBC1D8(7), TFDP1(2), TGFB1(3), WEE1(10) 58679171 472 220 465 137 244 19 63 53 91 2 0.446 1.000 1.000 137 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 87 AKT1(3), AKT2(5), AKT3(8), BCL10(3), CARD11(14), CBL(8), CBLB(13), CBLC(3), CD247(1), CD28(4), CD3E(2), CD3G(2), CD4(3), CD40LG(2), CD8A(2), CDC42(4), CDK4(6), CHUK(7), CTLA4(1), FOS(4), FYN(7), GRAP2(3), GRB2(3), ICOS(2), IFNG(2), IKBKB(11), IL10(1), IL2(1), IL5(1), ITK(6), JUN(4), LAT(1), LCK(2), LCP2(5), MALT1(8), MAP3K8(5), NCK1(2), NCK2(5), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDCD1(3), PDK1(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKCQ(10), PTPN6(2), PTPRC(19), RASGRP1(6), SOS1(23), SOS2(8), TEC(10), TNF(4), VAV1(8), VAV2(8), VAV3(7), ZAP70(3) 56657769 478 218 472 143 248 19 93 49 69 0 0.506 1.000 1.000 138 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(15), BDKRB1(4), BDKRB2(3), C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C3AR1(4), C4BPA(8), C4BPB(3), C5(9), C5AR1(3), C6(9), C7(4), C8A(7), C8B(3), C8G(2), C9(8), CD46(8), CD55(2), CFB(10), CFH(13), CFI(3), CPB2(5), CR1(14), CR2(17), F10(6), F11(10), F12(3), F13A1(8), F13B(9), F2(3), F2R(2), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), KNG1(5), MASP1(12), MASP2(5), MBL2(1), PLAT(6), PLAU(2), PLAUR(7), PLG(4), PROC(2), PROS1(14), SERPINA1(1), SERPINA5(5), SERPINC1(7), SERPIND1(6), SERPINE1(6), SERPING1(3), THBD(4), VWF(21) 52489557 426 215 420 145 190 23 109 51 53 0 0.901 1.000 1.000 139 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), BRAF(9), CHUK(7), DAXX(9), ELK1(1), FOS(4), GRB2(3), IKBKB(11), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K5(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(5), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K6(9), MAP3K7(8), MAP3K8(5), MAP3K9(11), MAP4K1(8), MAP4K2(5), MAP4K3(12), MAP4K4(8), MAP4K5(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK4(5), MAPK6(4), MAPK7(3), MAPK8(5), MAPK9(5), MAPKAPK2(1), MAPKAPK3(3), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(6), PAK1(4), PAK2(9), RAC1(4), RAF1(4), RELA(6), RIPK1(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA4(3), RPS6KA5(9), RPS6KB1(4), RPS6KB2(1), SHC1(8), SP1(10), STAT1(13), TGFB1(3), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5) 54543081 451 215 447 158 230 20 77 46 75 3 0.960 1.000 1.000 140 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(3), AKT2(5), AKT3(8), CASP8(14), CCL3(2), CCL5(1), CD14(3), CD40(5), CD80(2), CD86(6), CHUK(7), CXCL10(2), CXCL11(1), CXCL9(3), FADD(7), FOS(4), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNAR1(2), IFNAR2(6), IFNB1(1), IKBKB(11), IKBKE(6), IL12A(1), IL12B(3), IL1B(3), IL6(4), IRAK1(3), IRAK4(7), IRF3(6), IRF5(4), IRF7(3), JUN(4), LBP(2), LY96(1), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K7(8), MAP3K8(5), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK9(5), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(6), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), RAC1(4), RELA(6), RIPK1(7), SPP1(2), STAT1(13), TBK1(7), TICAM1(9), TLR1(3), TLR2(3), TLR3(10), TLR4(6), TLR5(11), TLR6(6), TLR7(9), TLR8(9), TLR9(12), TNF(4), TOLLIP(3), TRAF3(2), TRAF6(1) 50698207 419 211 414 128 222 20 74 38 64 1 0.319 1.000 1.000 141 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AIFM1(4), AKT1(3), AKT2(5), AKT3(8), APAF1(7), ATM(65), BAD(3), BAX(2), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CAPN1(5), CAPN2(2), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(5), CYCS(1), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL3RA(6), IRAK1(3), IRAK2(5), IRAK3(9), IRAK4(7), MYD88(2), NFKB1(3), NFKB2(3), NFKBIA(6), NTRK1(7), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKACA(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), RIPK1(7), TNF(4), TNFRSF10A(5), TNFRSF10B(6), TNFRSF10C(5), TNFRSF10D(4), TNFRSF1A(5), TNFSF10(5), TRADD(2), TRAF2(5) 46609910 395 209 388 125 203 17 62 36 76 1 0.710 1.000 1.000 142 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 90 CD2BP2(8), CDC40(2), CLK2(10), CLK3(2), CLK4(3), COL2A1(14), CPSF1(9), CPSF2(3), CPSF3(8), CPSF4(3), CSTF1(2), CSTF2(6), CSTF2T(5), CSTF3(4), DDIT3(1), DDX1(8), DDX20(10), DHX15(12), DHX16(9), DHX38(6), DHX8(12), DHX9(21), DICER1(19), DNAJC8(1), FUS(9), GIPC1(2), LSM2(2), LSM7(1), NCBP1(2), NCBP2(1), NONO(4), NUDT21(1), NXF1(10), PABPN1(4), PAPOLA(10), PHF5A(2), POLR2A(13), PPM1G(10), PRPF18(6), PRPF3(10), PRPF4(5), PRPF4B(8), PRPF8(8), PSKH1(3), PTBP1(2), PTBP2(8), RBM17(11), RBM5(12), RNGTT(4), RNMT(4), RNPS1(2), SF3A1(6), SF3A3(7), SF3B2(5), SF3B4(3), SF3B5(2), SNRPA(6), SNRPA1(3), SNRPB(8), SNRPB2(3), SNRPD1(1), SNRPD2(1), SNRPD3(1), SNRPE(2), SNRPG(2), SNRPN(5), SPOP(6), SRPK1(2), SRPK2(6), SRRM1(5), SUPT5H(11), U2AF1(9), U2AF2(4), XRN2(7) 59176586 437 209 428 138 235 27 74 36 64 1 0.981 1.000 1.000 143 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(6), CD14(3), CD19(4), CD1A(7), CD1B(3), CD1C(2), CD1E(13), CD2(2), CD22(4), CD33(6), CD34(3), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(3), CD44(2), CD5(3), CD55(2), CD7(3), CD8A(2), CD9(3), CR1(14), CR2(17), CSF1(4), CSF1R(11), CSF2RA(7), CSF3(1), CSF3R(5), DNTT(11), EPO(2), EPOR(5), FCGR1A(2), FLT3(10), FLT3LG(1), GP5(1), GP9(3), GYPA(5), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1B(3), IL1R1(1), IL1R2(3), IL2RA(1), IL3RA(6), IL4R(6), IL5(1), IL5RA(4), IL6(4), IL6R(4), IL7(1), IL7R(7), IL9R(3), ITGA1(7), ITGA2(6), ITGA2B(13), ITGA3(10), ITGA4(19), ITGA5(8), ITGA6(9), ITGAM(13), ITGB3(9), KIT(9), KITLG(5), MME(13), MS4A1(5), TFRC(9), THPO(6), TNF(4), TPO(16) 46883017 392 205 389 127 157 21 101 55 58 0 0.563 1.000 1.000 144 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 59 AKT1(3), AKT2(5), AKT3(8), BAD(3), BCL2L1(4), CDC42(4), CDK2(1), CDKN1B(6), CREB3(5), CREB5(11), EBP(1), ERBB4(11), F2RL2(2), GAB1(7), GADD45A(1), GRB2(3), GSK3A(2), GSK3B(5), IGF1(2), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), MET(19), MYC(2), NOLC1(3), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PARD3(23), PARD6A(7), PDK1(2), PIK3CD(7), PPP1R13B(7), PREX1(15), PTK2(15), PTPN1(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SFN(1), SHC1(8), SLC2A4(4), SOS1(23), SOS2(8), TSC2(11), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 41462596 374 205 369 105 181 13 83 37 57 3 0.342 1.000 1.000 145 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(11), APAF1(7), ARHGDIB(1), BAG4(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CRADD(1), CYCS(1), DAXX(9), DFFA(6), DFFB(1), FADD(7), GSN(2), LMNA(5), LMNB1(4), LMNB2(7), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK8(5), MDM2(6), NFKB1(3), NFKBIA(6), NUMA1(16), PAK2(9), PRKCD(8), PRKDC(35), PSEN1(8), PSEN2(2), PTK2(15), RASA1(8), RELA(6), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 38965117 365 201 362 115 201 17 55 17 75 0 0.851 1.000 1.000 146 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(21), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADIPOQ(2), ADIPOR1(8), ADIPOR2(1), AGRP(2), AKT1(3), AKT2(5), AKT3(8), CAMKK1(3), CAMKK2(5), CD36(2), CHUK(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), G6PC(2), G6PC2(2), IKBKB(11), IRS1(9), IRS2(5), IRS4(18), JAK1(9), JAK2(8), JAK3(12), LEP(1), LEPR(8), MAPK10(9), MAPK8(5), MAPK9(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NPY(2), PCK1(9), PCK2(2), POMC(1), PPARA(1), PPARGC1A(18), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3), PRKCQ(10), PTPN11(4), RELA(6), RXRB(4), RXRG(8), SLC2A1(4), SLC2A4(4), SOCS3(1), STAT3(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TYK2(9) 47548155 371 201 368 119 178 19 78 37 59 0 0.453 1.000 1.000 147 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(35), ASH2L(1), CARM1(6), CTCFL(5), DOT1L(21), EED(5), EHMT1(8), EHMT2(12), EZH1(6), EZH2(6), FBXO11(6), HCFC1(4), HSF4(4), JMJD4(4), JMJD6(4), MEN1(3), NSD1(23), OGT(5), PAXIP1(8), PPP1CA(8), PPP1CB(4), PPP1CC(2), PRDM2(18), PRDM7(5), PRDM9(13), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), RBBP5(4), SATB1(6), SETD1A(9), SETD2(32), SETD7(3), SETD8(3), SETDB1(14), SETDB2(3), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(1), SUV39H2(1), SUV420H1(20), SUV420H2(2), SUZ12(9), WHSC1(18), WHSC1L1(16) 67467511 392 196 386 127 226 12 58 46 50 0 0.987 1.000 1.000 148 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 60 ATM(65), CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNG2(4), CCNH(4), CDC25A(5), CDK2(1), CDK4(6), CDK7(6), CDKN1B(6), CDKN2B(3), CDKN2C(2), CDKN2D(1), CREB3(5), CREB3L3(8), CREB3L4(7), E2F1(3), E2F2(4), E2F3(5), E2F4(2), E2F5(3), E2F6(2), GADD45A(1), GBA2(1), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), MDM2(6), MNAT1(4), MYC(2), MYT1(10), NACA(14), PCNA(4), POLA2(11), POLE(27), POLE2(4), RBL1(9), RPA2(1), RPA3(4), TFDP1(2), TFDP2(5), TNXB(38), WEE1(10) 42785091 364 196 355 110 189 17 65 32 60 1 0.627 1.000 1.000 149 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT1(3), AKT2(5), AKT3(8), BAD(3), CASP9(6), CDC42(4), KDR(19), MAP2K1(3), MAP2K2(5), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPKAPK2(1), MAPKAPK3(3), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NOS3(11), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PRKCA(3), PRKCG(7), PTGS2(6), PTK2(15), PXN(3), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SH2D2A(6), SHC2(3), SPHK1(1), SPHK2(11), SRC(5), VEGFA(7) 39635551 342 192 340 107 161 18 72 35 56 0 0.460 1.000 1.000 150 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(3), AKT2(5), AKT3(8), BAD(3), BCR(3), BLNK(8), BTK(5), CD19(4), CD22(4), CD81(2), CR2(17), CSK(7), DAG1(3), FLOT1(4), FLOT2(5), GRB2(3), GSK3A(2), GSK3B(5), INPP5D(5), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), MAP4K1(8), MAPK3(8), NFATC1(14), NFATC2(13), NR0B2(2), PDK1(2), PIK3CD(7), PIK3R1(7), PLCG2(6), PPP1R13B(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PTPRC(19), RAF1(4), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8) 41679630 334 189 332 120 165 19 68 35 47 0 0.854 1.000 1.000 151 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 ADAM17(7), APH1A(3), CREBBP(50), CTBP1(6), CTBP2(10), DLL1(9), DLL3(4), DLL4(5), DTX1(5), DTX2(6), DTX3(4), DTX3L(9), DTX4(3), DVL1(5), DVL2(9), DVL3(4), HDAC1(4), HDAC2(3), JAG1(13), JAG2(1), LFNG(2), MAML1(3), MAML2(6), MAML3(5), NCOR2(19), NCSTN(10), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), NUMB(3), NUMBL(1), PSEN1(8), PSEN2(2), RBPJ(3), RBPJL(6), RFNG(1), SNW1(11) 36459340 294 187 289 96 122 11 73 24 61 3 0.647 1.000 1.000 152 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 58 AKT1(3), AKT2(5), AKT3(8), BCL10(3), BLNK(8), BTK(5), CARD11(14), CD19(4), CD22(4), CD72(2), CD79A(4), CD79B(2), CD81(2), CHUK(7), CR2(17), FCGR2B(2), FOS(4), GSK3B(5), IKBKB(11), INPP5D(5), JUN(4), LILRB3(12), LYN(5), MALT1(8), NFAT5(15), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLCG2(6), PPP3CA(7), PPP3CB(7), PPP3CC(4), PPP3R1(1), PPP3R2(2), PTPN6(2), RAC1(4), RAC2(1), RAC3(3), RASGRP3(5), SYK(8), VAV1(8), VAV2(8), VAV3(7) 41107140 350 185 346 105 165 20 68 36 61 0 0.406 1.000 1.000 153 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(7), ATM(65), ATR(32), BAI1(5), BAX(2), BID(2), CASP3(3), CASP8(14), CASP9(6), CCNB1(5), CCNB3(9), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNE2(8), CCNG1(2), CCNG2(4), CD82(3), CDK2(1), CDK4(6), CDK6(5), CHEK1(3), CHEK2(11), CYCS(1), DDB2(8), EI24(1), FAS(1), GADD45A(1), GADD45G(1), GTSE1(5), IGF1(2), IGFBP3(1), MDM2(6), MDM4(2), PERP(2), PMAIP1(1), PPM1D(5), RCHY1(2), RFWD2(6), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(3), SERPINE1(6), SESN1(10), SESN2(2), SESN3(11), SFN(1), SIAH1(3), STEAP3(3), THBS1(8), TNFRSF10B(6), TP53I3(4), TP73(6), TSC2(11), ZMAT3(3) 36359642 340 184 330 103 182 18 54 32 52 2 0.724 1.000 1.000 154 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(14), ADAM17(7), ATP6AP1(3), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), CASP3(3), CCL5(1), CDC42(4), CHUK(7), CSK(7), CXCL1(1), EGFR(7), F11R(5), GIT1(6), HBEGF(1), IGSF5(4), IKBKB(11), JAM2(1), JAM3(4), JUN(4), LYN(5), MAP2K4(4), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK8(5), MAPK9(5), MET(19), NFKB1(3), NFKB2(3), NFKBIA(6), NOD1(6), PAK1(4), PLCG1(12), PLCG2(6), PTPN11(4), PTPRZ1(20), RAC1(4), RELA(6), SRC(5), TCIRG1(6), TJP1(9) 40872207 330 182 325 87 174 13 68 27 48 0 0.0956 1.000 1.000 155 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(3), ASAH1(4), ATF1(2), BRAF(9), CAMP(1), CREB3(5), CREB5(11), CREBBP(50), CRKL(1), DAG1(3), EGR1(7), EGR2(3), EGR3(3), EGR4(5), ELK1(1), FRS2(10), GNAQ(3), JUN(4), MAP1B(19), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), NTRK1(7), OPN1LW(5), PIK3C2G(11), PIK3CD(7), PIK3R1(7), PTPN11(4), RPS6KA3(9), SHC1(8), SRC(5), TERF2IP(4), TH(2) 28285011 264 182 259 79 116 13 63 24 47 1 0.468 1.000 1.000 156 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(4), ACADL(2), ACADM(1), ACOX1(7), ACOX2(9), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADIPOQ(2), ANGPTL4(6), APOA1(2), APOA2(5), APOA5(4), APOC3(1), AQP7(7), CD36(2), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP27A1(9), CYP4A11(5), CYP4A22(7), CYP7A1(10), CYP8B1(5), DBI(2), EHHADH(6), FABP1(2), FABP2(1), FABP5(1), FABP6(1), FADS2(2), GK(2), GK2(6), HMGCS2(7), ILK(3), LPL(4), ME1(5), MMP1(3), NR1H3(4), PCK1(9), PCK2(2), PDPK1(2), PLTP(7), PPARA(1), PPARD(6), PPARG(13), RXRB(4), RXRG(8), SCD(2), SCP2(4), SLC27A1(6), SLC27A2(10), SLC27A4(2), SLC27A5(9), SLC27A6(6), SORBS1(10), UBC(9), UCP1(4) 37446194 299 180 290 104 144 15 76 23 41 0 0.670 1.000 1.000 157 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(29), AXIN1(4), CCND1(4), CCND2(1), CCND3(8), CSNK1E(3), CTNNB1(15), DVL1(5), DVL2(9), DVL3(4), FBXW2(5), FOSL1(3), FZD1(4), FZD10(11), FZD2(3), FZD3(6), FZD5(1), FZD6(11), FZD7(7), FZD8(4), FZD9(3), GSK3B(5), JUN(4), LDLR(10), MAPK10(9), MAPK9(5), MYC(2), PAFAH1B1(2), PLAU(2), PPP2R5C(6), PPP2R5E(5), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCI(8), PRKCQ(10), PRKCZ(4), PRKD1(12), RAC1(4), SFRP4(5), TCF7(3), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1) 34565515 299 180 289 104 162 15 51 24 47 0 0.715 1.000 1.000 158 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(5), ALG6(3), CCKBR(9), CCR3(3), CCR5(6), CELSR1(20), CELSR2(18), CELSR3(29), CHRM2(5), CHRM3(8), CIDEB(2), CXCR3(3), DRD4(1), EDNRA(4), EMR2(6), EMR3(4), F2R(2), FSHR(5), GHRHR(5), GNRHR(2), GPR116(10), GPR132(4), GPR133(12), GPR135(2), GPR143(1), GPR17(3), GPR18(3), GPR55(2), GPR61(7), GPR84(2), GPR88(3), GRM1(22), GRPR(1), HRH4(3), LGR6(8), LPHN2(23), LPHN3(21), LTB4R2(3), NTSR1(2), OR2M4(3), P2RY13(3), PTGFR(7), SMO(8), TAAR5(2), TSHR(8), VN1R1(2) 38569589 305 179 298 129 127 14 88 38 37 1 0.658 1.000 1.000 159 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(16), CANT1(1), CDA(1), CTPS2(3), DCK(6), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ENTPD3(5), ENTPD5(4), ENTPD6(2), ENTPD8(5), ITPA(1), NME1(1), NME2(3), NME4(1), NME6(1), NME7(3), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), PNPT1(10), POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2), PRIM2(1), RFC5(5), RRM1(4), RRM2(4), RRM2B(2), TK1(3), TK2(1), TXNRD1(6), TXNRD2(1), TYMS(3), UCK1(3), UMPS(4), UPB1(4), UPP2(3), UPRT(5) 47018508 327 178 324 128 173 20 53 37 43 1 0.985 1.000 1.000 160 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(3), AKT2(5), AKT3(8), BRD4(15), CAP1(12), CBL(8), CDC42(4), F2RL2(2), FLOT1(4), FLOT2(5), GRB2(3), GSK3A(2), GSK3B(5), IGFBP1(4), INPPL1(11), IRS1(9), IRS2(5), IRS4(18), LNPEP(7), MAPK3(8), PARD3(23), PARD6A(7), PDK1(2), PIK3CD(7), PIK3R1(7), PTPN1(5), RAF1(4), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SERPINB6(4), SFN(1), SHC1(8), SLC2A4(4), SORBS1(10), SOS1(23), SOS2(8), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 32550034 299 177 295 88 162 10 51 35 38 3 0.502 1.000 1.000 161 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(2), IMPA1(1), IMPA2(4), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPP5B(4), INPP5E(1), INPPL1(11), IPMK(2), ISYNA1(2), ITPK1(4), ITPKA(4), ITPKB(5), MINPP1(5), MIOX(2), OCRL(4), PI4KA(11), PI4KB(13), PIK3C3(11), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIP4K2A(7), PIP4K2B(2), PIP4K2C(7), PIP5K1A(8), PIP5K1B(3), PIP5K1C(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCD3(6), PLCD4(5), PLCE1(11), PLCG1(12), PLCG2(6), PLCZ1(5), PTPMT1(3), SYNJ1(20), SYNJ2(8) 41328880 298 175 294 109 160 9 70 30 29 0 0.843 1.000 1.000 162 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(5), BAK1(2), BAX(2), BFAR(7), BTK(5), CAD(16), CASP10(1), CASP3(3), CASP8(14), CD7(3), CSNK1A1(6), DAXX(9), DEDD(6), DFFA(6), DIABLO(3), EGFR(7), EPHB2(10), FADD(7), FAF1(4), HSPB1(1), IL1A(1), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MET(19), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), NR0B2(2), PFN1(4), PFN2(1), PTPN13(19), RALBP1(2), RIPK1(7), ROCK1(8), SMPD1(7), TNFRSF6B(1), TPX2(7), TRAF2(5), TUFM(3) 41511088 311 175 308 103 164 9 70 26 42 0 0.847 1.000 1.000 163 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(9), CPEB1(8), EGFR(7), ERBB2(54), ERBB4(11), ETS1(5), ETS2(5), ETV6(12), ETV7(4), FMN2(26), GRB2(3), MAP2K1(3), MAPK3(8), NOTCH1(17), NOTCH2(11), NOTCH3(12), NOTCH4(14), PIWIL1(12), PIWIL2(8), PIWIL3(6), PIWIL4(8), RAF1(4), SOS1(23), SOS2(8), SPIRE1(2), SPIRE2(9) 29897897 289 174 255 84 145 18 58 32 34 2 0.521 1.000 1.000 164 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(7), BAD(3), BAK1(2), BAX(2), BCL2L1(4), BCL2L11(3), BID(2), BIRC2(3), BIRC3(3), BIRC5(2), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CHUK(7), CYCS(1), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), GZMB(2), HELLS(5), IKBKB(11), IRF1(1), IRF2(6), IRF3(6), IRF4(3), IRF5(4), IRF6(4), IRF7(3), JUN(4), LTA(1), MAP2K4(4), MAP3K1(10), MAPK10(9), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), PLEKHG5(7), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF10B(6), TNFRSF1A(5), TNFRSF1B(6), TNFRSF21(5), TNFRSF25(3), TNFSF10(5), TP73(6), TRADD(2), TRAF2(5), TRAF3(2) 32709446 280 171 273 93 154 14 50 20 42 0 0.801 1.000 1.000 165 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(3), ACTR3(2), AKT1(3), AKT2(5), AKT3(8), ANGPTL2(3), ARHGAP1(1), ARHGAP4(3), ARHGEF11(11), BTK(5), CDC42(4), CFL1(1), CFL2(4), GDI1(3), GDI2(5), INPPL1(11), ITPR1(21), ITPR2(33), ITPR3(9), LIMK1(6), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PDK1(2), PIK3CD(7), PIK3CG(10), PIK3R1(7), PITX2(7), PPP1R13B(7), RACGAP1(6), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), SAG(2), WASF1(5), WASL(2) 39011902 283 171 279 95 147 11 51 34 40 0 0.744 1.000 1.000 166 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(3), AKT2(5), AKT3(8), BTK(5), FCER1A(5), FCER1G(1), FYN(7), GAB2(8), GRB2(3), IL5(1), INPP5D(5), LAT(1), LCP2(5), LYN(5), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK9(5), MS4A2(6), PDK1(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCG1(12), PLCG2(6), PRKCA(3), PRKCD(8), PRKCE(5), RAC1(4), RAC2(1), RAC3(3), RAF1(4), SOS1(23), SOS2(8), SYK(8), TNF(4), VAV1(8), VAV2(8), VAV3(7) 39722185 315 170 313 118 152 10 68 45 40 0 0.947 1.000 1.000 167 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(10), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6) 30424117 268 169 259 80 144 10 55 23 35 1 0.525 1.000 1.000 168 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(9), ACTB(20), ACTG1(11), ARHGEF2(7), ARPC5(5), CD14(3), CDC42(4), CDH1(15), CLDN1(3), CTNNB1(15), CTTN(10), EZR(12), FYN(7), HCLS1(5), ITGB1(3), KRT18(5), LY96(1), NCK1(2), NCK2(5), NCL(3), OCLN(4), PRKCA(3), ROCK1(8), ROCK2(15), TLR4(6), TLR5(11), TUBA1A(9), TUBA1B(4), TUBA1C(3), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB(8), TUBB1(1), TUBB2A(3), TUBB2B(2), TUBB3(5), TUBB6(6), TUBB8(4), WAS(4), WASL(2), YWHAQ(3), YWHAZ(6) 30424117 268 169 259 80 144 10 55 23 35 1 0.525 1.000 1.000 169 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(4), AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), AFMID(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CARM1(6), CAT(9), CYP1A1(2), CYP1A2(4), CYP1B1(3), DDC(8), ECHS1(1), EHHADH(6), GCDH(6), HAAO(1), HADH(5), HADHA(4), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(1), LCMT1(2), LCMT2(12), LNX1(4), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), NFX1(8), OGDH(21), OGDHL(10), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), TDO2(3), TPH1(3), TPH2(4), WARS(5), WARS2(2), WBSCR22(7) 35180634 249 168 241 77 130 10 43 26 40 0 0.374 1.000 1.000 170 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 46 ACOX1(7), APOA1(2), APOA2(5), CD36(2), CITED2(3), CPT1B(4), CREBBP(50), DUSP1(3), DUT(2), EHHADH(6), FABP1(2), HSD17B4(5), HSPA1A(3), JUN(4), LPL(4), MAPK3(8), ME1(5), MRPL11(2), MYC(2), NCOA1(25), NCOR1(42), NCOR2(19), NFKBIA(6), NR0B2(2), NR1H3(4), NR2F1(3), NRIP1(7), PIK3R1(7), PPARA(1), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), PTGS2(6), RELA(6), SP1(10), SRA1(4), STAT5A(1), STAT5B(5), TNF(4) 30935017 296 167 290 82 131 10 56 25 73 1 0.296 1.000 1.000 171 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(18), ATP4A(5), ATP4B(2), ATP5A1(7), ATP5B(5), ATP5C1(4), ATP5E(1), ATP5F1(4), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5I(1), ATP5J(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), COX10(4), COX15(4), COX17(2), COX4I2(1), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(3), COX7B(1), COX7B2(3), COX8A(1), CYC1(7), LHPP(2), NDUFA1(1), NDUFA10(5), NDUFA12(1), NDUFA13(3), NDUFA5(1), NDUFA6(2), NDUFA7(2), NDUFA8(4), NDUFA9(4), NDUFAB1(2), NDUFB10(2), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFB9(3), NDUFS1(5), NDUFS2(3), NDUFS3(4), NDUFS4(3), NDUFS6(1), NDUFS7(3), NDUFS8(1), NDUFV1(4), NDUFV2(6), NDUFV3(4), PPA1(1), PPA2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), TCIRG1(6), UQCRB(1), UQCRC1(2), UQCRC2(4), UQCRFS1(3), UQCRH(2) 32357592 295 165 289 91 148 13 59 32 43 0 0.355 1.000 1.000 172 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1C1(2), AKR1C2(1), AKR1C3(3), AKR1C4(5), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), CYP1A1(2), CYP1A2(4), CYP1B1(3), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2F1(4), CYP2S1(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHDH(3), EPHX1(5), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), MGST1(1), MGST2(1), MGST3(1), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2) 33419411 250 162 249 91 120 14 49 30 37 0 0.743 1.000 1.000 173 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(4), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(4), CAMK1(5), CAMK1G(4), CAMK4(4), CREBBP(50), CSNK1A1(6), EDN1(2), ELSPBP1(3), F2(3), FKBP1A(1), GATA4(1), GSK3B(5), HAND1(4), HAND2(2), IGF1(2), LIF(2), MAP2K1(3), MAPK14(3), MAPK3(8), MAPK8(5), MEF2C(5), MYH2(22), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NKX2-5(5), NPPA(2), PIK3R1(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAF1(4), RPS6KB1(4), SYT1(6) 27968651 272 162 268 78 108 19 60 27 56 2 0.383 1.000 1.000 174 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(7), ADCY6(15), ADCY8(18), CACNA1A(25), CACNA1B(20), GNAS(12), GNAT3(2), GNB1(7), GNB3(5), GNG3(3), GRM4(9), ITPR3(9), KCNB1(8), PDE1A(8), PLCB2(6), PRKACA(2), PRKACB(4), PRKACG(2), PRKX(1), SCNN1A(12), SCNN1B(6), SCNN1G(5), TAS1R1(2), TAS1R2(7), TAS1R3(20), TAS2R1(1), TAS2R13(2), TAS2R14(1), TAS2R16(4), TAS2R3(3), TAS2R39(3), TAS2R4(1), TAS2R40(2), TAS2R41(3), TAS2R43(1), TAS2R46(3), TAS2R5(1), TAS2R50(3), TAS2R60(5), TAS2R7(1), TAS2R8(1), TAS2R9(6), TRPM5(6) 32728290 262 161 249 119 141 16 60 23 22 0 0.762 1.000 1.000 175 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(45), B3GALT4(6), CDR1(4), DGKI(9), FAU(2), IL6ST(9), MRPL19(2), PIGK(4), RPL10(3), RPL11(2), RPL13(3), RPL15(3), RPL17(1), RPL19(2), RPL23(4), RPL24(4), RPL26(1), RPL28(3), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL3L(3), RPL4(5), RPL41(1), RPL5(3), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS12(3), RPS13(2), RPS15(1), RPS16(4), RPS18(6), RPS19(1), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS27A(1), RPS29(1), RPS3(1), RPS3A(1), RPS4X(4), RPS4Y1(1), RPS5(1), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), RPS7(2), RPS8(2), RPS9(3), RPSA(4), SLC36A2(1), TBC1D10C(5), TSPAN9(2), UBA52(7), UBC(9) 30355677 262 160 258 100 129 20 55 26 31 1 0.924 1.000 1.000 176 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), AKT2(5), AKT3(8), ASAH1(4), BRAF(9), DAG1(3), DRD2(5), EGFR(7), EPHB2(10), GRB2(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PI3(1), PIK3CB(11), PITX2(7), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), RAF1(4), RGS20(3), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT3(6), TERF2IP(4) 34007869 262 160 257 93 136 9 54 33 30 0 0.791 1.000 1.000 177 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(6), BMP6(5), BMP7(4), BMP8B(3), BTRC(4), CSNK1A1(6), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(6), CSNK1G3(3), FBXW11(1), GLI1(10), GLI2(16), GLI3(19), GSK3B(5), HHIP(10), IHH(3), LRP2(46), PRKACA(2), PRKACB(4), PRKACG(2), PRKX(1), PTCH1(19), PTCH2(5), RAB23(2), SHH(6), SMO(8), STK36(13), SUFU(2), WNT10B(4), WNT11(3), WNT16(4), WNT2(3), WNT2B(4), WNT3(1), WNT3A(4), WNT4(1), WNT5A(3), WNT5B(3), WNT6(1), WNT7A(5), WNT7B(1), WNT8A(1), WNT9A(2), WNT9B(2), ZIC2(7) 35144072 278 159 275 113 120 13 77 22 46 0 0.980 1.000 1.000 178 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(65), ATR(32), BRCA1(23), BRCA2(49), CHEK1(3), CHEK2(11), FANCA(18), FANCC(9), FANCD2(19), FANCE(3), FANCF(4), FANCG(5), HUS1(1), MRE11A(7), RAD1(3), RAD17(6), RAD50(13), RAD51(7), RAD9A(2), TREX1(8) 25324274 288 157 281 46 149 18 40 33 45 3 0.00760 1.000 1.000 179 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(5), ALPL(4), ALPP(3), ASCC3(24), ATP13A2(15), DDX18(11), DDX19A(4), DDX23(13), DDX4(12), DDX41(2), DDX47(2), DDX50(5), DDX51(2), DDX52(8), DDX54(9), DDX55(5), DHX58(3), ENTPD7(5), EP400(23), ERCC3(7), FPGS(4), GCH1(2), GGH(3), IFIH1(8), MOV10L1(7), NUDT5(3), QDPR(3), RAD54B(5), RAD54L(9), RUVBL2(2), SETX(27), SKIV2L2(9), SMARCA2(24), SMARCA5(4) 35583173 272 157 269 96 137 12 59 32 32 0 0.924 1.000 1.000 180 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(19), AMY2A(3), AMY2B(9), ENPP1(7), ENPP3(6), G6PC(2), GAA(5), GANAB(16), GBE1(2), GCK(1), GPI(4), GUSB(3), GYS1(12), GYS2(13), HK1(15), HK2(11), HK3(8), MGAM(16), PGM1(3), PGM3(2), PYGB(8), PYGL(4), PYGM(13), RNPC3(1), SI(23), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UXS1(3) 33041540 262 156 260 96 118 17 58 32 37 0 0.940 1.000 1.000 181 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(3), BDKRB2(3), CALM1(2), CALM2(2), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(10), KDR(19), NOS3(11), PDE2A(2), PDE3A(11), PDE3B(9), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKG1(10), PRKG2(8), RYR2(83), SLC7A1(8), SYT1(6), TNNI1(5) 23210929 230 154 229 92 95 13 56 33 32 1 0.968 1.000 1.000 182 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(36), EEF1A2(3), EEF1B2(2), EEF1D(2), EEF1G(4), EEF2(5), EEF2K(7), EIF2AK1(5), EIF2AK2(7), EIF2AK3(12), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4EBP2(3), EIF4G1(17), EIF4G3(27), EIF5(9), EIF5A(5), EIF5B(11), ETF1(2), GSPT2(6), PABPC1(7), PABPC3(8), PAIP1(11), SLC35A4(3) 25401472 250 153 247 55 126 12 47 28 37 0 0.128 1.000 1.000 183 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CFLAR(2), DAXX(9), DFFA(6), DFFB(1), FADD(7), FAF1(4), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), PTPN13(19), RIPK2(5), SPTAN1(68) 22415835 241 151 237 72 125 8 33 12 62 1 0.876 1.000 1.000 184 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), CARM1(6), COMT(3), DBH(4), DCT(9), DDC(8), ECH1(8), ESCO1(3), ESCO2(3), FAH(3), GOT1(2), GSTZ1(2), HEMK1(1), HGD(4), HPD(4), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), MIF(1), NAT6(1), PNPLA3(4), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SH3GLB1(1), TAT(5), TH(2), TPO(16), TYR(12), TYRP1(2), WBSCR22(7) 34515087 228 150 224 64 105 6 56 26 35 0 0.191 1.000 1.000 185 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(1), CDC42(4), DLD(7), DUSP10(4), DUSP4(3), DUSP8(6), GAB1(7), GADD45A(1), GCK(1), IL1R1(1), JUN(4), MAP2K4(4), MAP2K5(4), MAP2K7(3), MAP3K1(10), MAP3K10(2), MAP3K11(5), MAP3K12(9), MAP3K13(16), MAP3K2(6), MAP3K3(3), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK10(9), MAPK7(3), MAPK8(5), MAPK9(5), MYEF2(5), NFATC3(14), NR2C2(7), PAPPA(15), SHC1(8), TRAF6(1), ZAK(11) 28734874 240 150 237 78 119 12 57 20 32 0 0.878 1.000 1.000 186 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(5), AKR1D1(5), ARSD(7), ARSE(2), CARM1(6), CYP11B1(6), CYP11B2(13), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(1), HSD17B12(3), HSD17B2(6), HSD17B3(1), HSD17B7(3), HSD17B8(4), HSD3B1(5), HSD3B2(5), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SRD5A1(5), STS(5), SULT1E1(1), SULT2A1(4), SULT2B1(2), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), WBSCR22(7) 29200143 224 149 219 64 111 12 48 31 22 0 0.195 1.000 1.000 187 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(4), AASS(11), ACAT1(5), ACAT2(1), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(23), OGDH(21), OGDHL(10), PIPOX(4), PLOD1(3), PLOD2(5), PLOD3(5), RDH12(2), RDH13(1), SETD1A(9), SETD7(3), SETDB1(14), SHMT1(3), SHMT2(2), SPCS3(1), SUV39H1(1), SUV39H2(1), TMLHE(2) 33573987 232 149 226 114 129 9 41 20 33 0 1.000 1.000 1.000 188 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), CDIPT(3), CDS1(5), CDS2(3), CHAT(5), CHKA(5), CHKB(4), CHPT1(6), CRLS1(1), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), ESCO1(3), ESCO2(3), ETNK1(4), ETNK2(1), GNPAT(4), GPAM(5), GPD1(6), GPD1L(3), GPD2(10), LCAT(3), LYPLA1(2), LYPLA2(2), NAT6(1), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(7), PTDSS2(1), SH3GLB1(1) 37665706 247 149 246 91 118 15 52 24 38 0 0.893 1.000 1.000 189 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AKR1A1(2), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CEL(8), DAK(4), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKI(9), DGKQ(3), DGKZ(3), GK(2), GK2(6), GLA(3), GLB1(5), GPAM(5), LCT(16), LIPA(3), LIPC(6), LIPF(6), LIPG(4), LPL(4), MGLL(3), PNLIP(5), PNLIPRP1(8), PNPLA3(4), PPAP2A(5), PPAP2B(3), PPAP2C(1) 33796651 255 148 253 90 120 14 54 27 40 0 0.619 1.000 1.000 190 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(3), AGTR2(4), ATP8A1(12), AVPR1A(4), AVPR1B(3), AVPR2(4), BDKRB1(4), BDKRB2(3), BRS3(4), C3AR1(4), CCKAR(3), CCKBR(9), CCR1(1), CCR10(3), CCR3(3), CCR4(3), CCR5(6), CCR6(2), CCR7(3), CCR8(5), CX3CR1(4), CXCR3(3), CXCR4(4), CXCR6(4), EDNRA(4), EDNRB(8), FPR1(3), FSHR(5), GALR1(3), GALR2(4), GALR3(3), GALT(1), GHSR(8), GNB2L1(3), GNRHR(2), GRPR(1), LHCGR(7), MC1R(2), MC3R(4), MC4R(3), MC5R(3), NMBR(6), NPY1R(7), NPY2R(4), NPY5R(5), NTSR1(2), NTSR2(2), OPRD1(5), OPRK1(4), OPRL1(2), OXTR(1), SSTR1(3), SSTR3(4), SSTR4(6), TAC4(1), TACR1(3), TACR2(1), TACR3(5), TRHR(9), TSHR(8) 30531920 240 148 239 129 98 6 73 35 28 0 0.974 1.000 1.000 191 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(5), ACAT2(1), ACMSD(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOC2(5), AOC3(6), AOX1(8), ASMT(1), CAT(9), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), DDC(8), ECHS1(1), EHHADH(6), GCDH(6), HAAO(1), HADHA(4), KMO(1), KYNU(1), MAOA(4), MAOB(2), SDS(2), TDO2(3), TPH1(3), WARS(5), WARS2(2) 32067281 228 148 225 84 111 10 46 27 34 0 0.687 1.000 1.000 192 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(7), ACSS2(3), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), G6PC2(2), GALM(2), GAPDH(3), GAPDHS(2), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKL(2), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGAM4(4), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1) 33826358 219 147 217 98 99 11 50 23 36 0 0.979 1.000 1.000 193 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(3), AKT2(5), AKT3(8), BCR(3), BTK(5), CD19(4), DAPP1(2), FLOT1(4), FLOT2(5), GAB1(7), ITPR1(21), ITPR2(33), ITPR3(9), LYN(5), NR0B2(2), PDK1(2), PHF11(5), PITX2(7), PLCG2(6), PPP1R13B(7), PREX1(15), PTPRC(19), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SAG(2), SYK(8), TEC(10), VAV1(8) 29871189 233 147 231 80 125 8 43 25 31 1 0.667 1.000 1.000 194 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(4), CASP2(2), CASP3(3), CASP8(14), CRADD(1), DFFA(6), DFFB(1), FADD(7), JUN(4), LMNA(5), LMNB1(4), LMNB2(7), MADD(12), MAP2K4(4), MAP3K1(10), MAP3K7(8), MAPK8(5), PAK1(4), PAK2(9), PRKDC(35), RIPK1(7), SPTAN1(68), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 21365070 237 147 232 62 128 10 27 13 59 0 0.373 1.000 1.000 195 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 BRCA1(23), CARM1(6), CCND1(4), CREBBP(50), ERCC3(7), ESR1(5), GRIP1(12), GTF2A1(3), GTF2E1(7), GTF2F1(5), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(6), HDAC6(12), MEF2C(5), NCOR2(19), NR0B1(4), NRIP1(7), PELP1(5), POLR2A(13), SRA1(4), TBP(2) 23528149 209 145 202 64 98 7 44 18 41 1 0.537 1.000 1.000 196 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(8), CD28(4), CSK(7), CTLA4(1), DAG1(3), EPHB2(10), GRAP2(3), GRB2(3), ITK(6), ITPKA(4), ITPKB(5), LAT(1), LCK(2), LCP2(5), NCK1(2), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PLCG1(12), PTPRC(19), RAF1(4), RASGRP1(6), RASGRP2(4), RASGRP3(5), RASGRP4(1), SOS1(23), SOS2(8), VAV1(8), ZAP70(3) 31335612 233 145 231 76 120 8 51 28 26 0 0.764 1.000 1.000 197 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(29), AXIN1(4), BTRC(4), CCND1(4), CREBBP(50), CSNK1A1(6), CSNK1D(3), CSNK2A1(11), CTBP1(6), CTNNB1(15), DVL1(5), FZD1(4), GSK3B(5), HDAC1(4), MAP3K7(8), MYC(2), NLK(6), PPARD(6), PPP2CA(2), TLE1(7), WIF1(6) 16992324 187 145 179 48 85 7 33 17 44 1 0.408 1.000 1.000 198 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), AKT2(5), AKT3(8), BRAF(9), CAB39(3), DDIT4(2), EIF4B(4), EIF4EBP1(1), FIGF(2), HIF1A(6), IGF1(2), MAPK3(8), PDPK1(2), PGF(2), PIK3CB(11), PIK3CD(7), PIK3CG(10), PIK3R1(7), PIK3R2(4), PIK3R3(5), PIK3R5(3), PRKAA1(9), PRKAA2(7), RHEB(4), RICTOR(19), RPS6(5), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KA6(11), RPS6KB1(4), RPS6KB2(1), TSC2(11), ULK1(9), ULK2(9), ULK3(1), VEGFA(7), VEGFB(3), VEGFC(6) 27958342 234 144 233 75 121 11 43 26 32 1 0.737 1.000 1.000 199 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(12), AR(5), ESR1(5), ESR2(4), ESRRA(2), HNF4A(5), NPM1(1), NR0B1(4), NR1D1(3), NR1D2(10), NR1H2(6), NR1H3(4), NR1I2(5), NR1I3(4), NR2C2(7), NR2E1(1), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(6), NR5A1(1), NR5A2(6), PGR(8), PPARA(1), PPARD(6), PPARG(13), RARA(6), RARB(9), RARG(21), ROR1(6), RORA(6), RORC(7), RXRB(4), RXRG(8), THRA(2), THRB(1), VDR(2) 23674169 208 144 202 76 109 10 47 19 23 0 0.772 1.000 1.000 200 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 CHUK(7), DAXX(9), EGF(17), EGFR(7), ETS1(5), ETS2(5), FOS(4), HOXA7(5), IKBKB(11), JUN(4), MAP2K1(3), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP2K7(3), MAP3K1(10), MAP3K5(14), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), NFKB1(3), NFKBIA(6), PPP2CA(2), PRKCA(3), PRKCD(8), PRKCE(5), PRKCG(7), PRKCH(7), PRKCQ(10), RAF1(4), RELA(6), RIPK1(7), SP1(10), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRAF2(5) 28267922 232 143 229 93 118 14 46 16 38 0 0.969 1.000 1.000 201 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(65), BMPR1B(5), CCND2(1), CDK4(6), CDKN1B(6), CEBPB(3), DAZL(3), DMC1(2), EGR1(7), ESR2(4), FSHR(5), GJA4(2), INHA(3), LHCGR(7), MLH1(9), NCOR1(42), NR5A1(1), NRIP1(7), PGR(8), PRLR(4), PTGER2(7), SMPD1(7), VDR(2), ZP2(8) 20364106 214 143 211 51 90 8 41 26 48 1 0.186 1.000 1.000 202 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(3), APC(29), ASAH1(4), CAMP(1), CAV3(1), DAG1(3), DLG4(6), EPHB2(10), GNAI1(4), GNAQ(3), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), PITX2(7), PTX3(6), RAC1(4), RHO(3), RYR1(54) 26624248 213 143 209 76 110 10 40 19 34 0 0.639 1.000 1.000 203 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(2), CALM2(2), CD3E(2), CD3G(2), ELK1(1), FOS(4), FYN(7), GRB2(3), JUN(4), LAT(1), LCK(2), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKBIA(6), PIK3R1(7), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), PTPN7(1), RAC1(4), RAF1(4), RASA1(8), RELA(6), SHC1(8), SOS1(23), SYT1(6), VAV1(8), ZAP70(3) 26292797 226 143 223 72 113 13 48 20 32 0 0.773 1.000 1.000 204 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(7), BAD(3), BAX(2), BCL2A1(1), BCL2L1(4), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CD40(5), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(6), DFFB(1), FADD(7), FAS(1), FASLG(1), IKBKE(6), LTA(1), MCL1(2), NFKB1(3), NFKBIA(6), NGFR(4), NR3C1(6), NTRK1(7), PTPN13(19), RIPK1(7), TFG(11), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5), TRAF3(2), TRAF6(1) 25113586 194 141 189 68 109 7 36 11 31 0 0.919 1.000 1.000 205 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), F10(6), F11(10), F12(3), F2(3), F2R(2), F5(24), F8(22), F9(3), FGA(17), FGB(5), FGG(7), KLKB1(2), PROC(2), PROS1(14), SERPINC1(7), SERPING1(3) 25660356 195 141 192 62 101 11 45 19 19 0 0.958 1.000 1.000 206 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(16), CANT1(1), CDA(1), CTPS2(3), DCK(6), DCTD(2), DHODH(2), DPYD(14), DPYS(13), DUT(2), ENTPD1(1), ITPA(1), NME1(1), NME2(3), NT5C(1), NT5E(6), POLD1(10), POLD2(3), POLE(27), POLG(8), POLL(1), POLQ(28), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5), RRM1(4), RRM2(4), TK1(3), TK2(1), TXNRD1(6), TYMS(3), UCK1(3), UMPS(4), UNG(1), UPB1(4) 33291369 231 141 230 95 115 13 37 31 34 1 0.983 1.000 1.000 207 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(5), CALM1(2), CALM2(2), ELK1(1), FCER1A(5), FCER1G(1), FOS(4), GRB2(3), JUN(4), LYN(5), MAP2K1(3), MAP2K4(4), MAP2K7(3), MAP3K1(10), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PAK2(9), PIK3R1(7), PLA2G4A(1), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8) 23526106 215 139 212 59 104 13 42 25 31 0 0.423 1.000 1.000 208 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(6), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPS(5), CDIPT(3), CDS1(5), CDS2(3), CHAT(5), CHKA(5), CHKB(4), CLC(2), CPT1B(4), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), ETNK1(4), GNPAT(4), GPD1(6), GPD2(10), LCAT(3), LGALS13(3), LYPLA1(2), LYPLA2(2), PAFAH1B1(2), PAFAH2(4), PCYT1A(2), PCYT1B(2), PEMT(1), PISD(3), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLCB2(6), PLCG1(12), PLCG2(6), PPAP2A(5), PPAP2B(3), PPAP2C(1) 28674293 228 139 227 80 109 10 49 20 40 0 0.565 1.000 1.000 209 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(29), AR(5), ASAH1(4), BRAF(9), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(3), EGFR(7), GNA11(3), GNA15(5), GNAI1(4), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), KCNJ3(4), KCNJ5(2), KCNJ9(3), MAPK10(9), MAPK14(3), PHKA2(8), PIK3CD(7), PIK3R1(7), PITX2(7), PTX3(6), RAF1(4), SRC(5) 29680445 217 139 214 83 111 8 37 27 34 0 0.921 1.000 1.000 210 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(9), CDC7(4), CDK2(1), CDT1(3), GMNN(1), MCM10(15), MCM2(3), MCM3(3), MCM4(10), MCM5(4), MCM6(7), MCM7(9), NACA(14), PCNA(4), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), RFC1(9), RFC2(5), RFC3(1), RFC4(10), RFC5(5), RPA2(1), RPA3(4), RPA4(1), RPS27A(1), UBA52(7), UBC(9) 28334208 200 138 194 62 118 9 32 17 24 0 0.542 1.000 1.000 211 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(3), B3GALT4(6), B3GALT5(3), B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALNT1(2), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), B4GALT6(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(10), PIGA(3), PIGB(5), PIGC(4), PIGF(4), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(6), PIGZ(3), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1), ST3GAL5(5), ST3GAL6(6), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(3), ST8SIA5(2), UGCG(3) 28060482 203 138 200 81 100 4 47 27 25 0 0.692 1.000 1.000 212 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 19 ATM(65), ATR(32), BRCA1(23), CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CDC34(1), CDKN2D(1), CHEK1(3), CHEK2(11), GADD45A(1), MDM2(6), MYT1(10), PRKDC(35), RPS6KA1(5), WEE1(10), YWHAH(2), YWHAQ(3) 20789837 222 137 217 44 105 14 36 25 40 2 0.0887 1.000 1.000 213 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(28), ACACB(21), ACAT1(5), ACAT2(1), ACOT12(6), ACSS1(7), ACSS2(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PCK2(2), PDHA1(5), PDHA2(6), PDHB(2), PKLR(8) 27167995 186 137 183 70 97 6 38 19 26 0 0.844 1.000 1.000 214 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(11), ACTG2(2), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), CDC42(4), CFL1(1), CFL2(4), FLNA(14), FLNC(18), FSCN1(5), FSCN2(3), FSCN3(3), GDI1(3), GDI2(5), LIMK1(6), MYH2(22), MYLK(15), MYLK2(7), PAK1(4), PAK2(9), PAK3(11), PAK4(1), PAK6(4), PAK7(6), PFN1(4), PFN2(1), RHO(3), ROCK1(8), ROCK2(15), RPS4X(4), VASP(1), WASF1(5), WASL(2) 27858435 212 137 210 70 97 8 54 25 28 0 0.564 1.000 1.000 215 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(5), AKT3(8), ANKRD6(4), APC(29), AXIN1(4), AXIN2(19), CER1(4), CSNK1A1(6), CTNNB1(15), DACT1(6), DKK1(2), DKK2(5), DKK3(5), DKK4(2), DVL1(5), FSTL1(4), GSK3A(2), GSK3B(5), LRP1(36), MVP(11), NKD1(3), NKD2(1), PSEN1(8), PTPRA(2), SENP2(1), SFRP1(2), WIF1(6) 23332724 203 137 198 49 106 6 41 18 31 1 0.0897 1.000 1.000 216 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1) 28427706 199 136 196 80 89 9 48 21 32 0 0.903 1.000 1.000 217 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AKR1A1(2), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), CEL(8), DGAT1(3), DGKA(9), DGKB(13), DGKD(8), DGKE(8), DGKG(17), DGKH(13), DGKQ(3), DGKZ(3), GK(2), GLA(3), GLB1(5), LCT(16), LIPC(6), LIPF(6), LIPG(4), LPL(4), PNLIP(5), PNLIPRP1(8), PPAP2A(5), PPAP2B(3), PPAP2C(1) 27691993 226 136 223 77 108 9 48 24 37 0 0.512 1.000 1.000 218 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1A1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), ALDOA(6), ALDOB(3), ALDOC(2), BPGM(1), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GCK(1), GPI(4), HK1(15), HK2(11), HK3(8), LDHB(2), LDHC(4), PDHA1(5), PDHA2(6), PDHB(2), PFKM(5), PFKP(4), PGAM1(1), PGK1(2), PGM1(3), PGM3(2), PKLR(8), TPI1(1) 28427706 199 136 196 80 89 9 48 21 32 0 0.903 1.000 1.000 219 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(8), BTK(5), CALM1(2), CALM2(2), CD79A(4), CD79B(2), ELK1(1), FOS(4), GRB2(3), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK14(3), MAPK3(8), MAPK8(5), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SYK(8), SYT1(6), VAV1(8) 22005177 209 134 206 59 101 12 41 24 31 0 0.465 1.000 1.000 220 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(5), ALG10B(6), ALG11(5), ALG12(3), ALG13(4), ALG14(1), ALG2(5), ALG3(2), ALG5(3), ALG6(3), ALG8(2), ALG9(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DHDDS(7), DOLPP1(1), DPAGT1(6), DPM1(3), FUT8(7), GANAB(16), MAN1A1(3), MAN1A2(6), MAN1B1(9), MAN1C1(6), MAN2A1(13), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), MGAT5B(7), RFT1(4), RPN1(3), RPN2(5), ST6GAL1(4), STT3B(5) 24433056 193 134 192 68 98 9 32 30 24 0 0.699 1.000 1.000 221 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(5), AKT3(8), ARHGEF11(11), CDC42(4), DLG4(6), GNA13(12), LPA(11), MAP2K4(4), MAP3K1(10), MAP3K5(14), MAPK8(5), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PDK1(2), PHKA2(8), PI3(1), PIK3CB(11), PLD1(9), PLD2(3), PLD3(5), PTK2(15), RDX(4), ROCK1(8), ROCK2(15), SERPINA4(2), SRF(4) 28584013 206 134 199 60 107 14 32 22 31 0 0.601 1.000 1.000 222 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(4), CARS(5), CARS2(7), DARS(3), DARS2(10), EARS2(3), EPRS(12), FARS2(1), FARSA(2), FARSB(6), GARS(6), HARS(6), HARS2(1), IARS(6), IARS2(10), KARS(11), LARS(11), LARS2(3), MARS(3), MARS2(5), MTFMT(2), NARS(4), NARS2(7), PARS2(4), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(6), TARS(9), TARS2(14), VARS(5), VARS2(12), WARS(5), WARS2(2), YARS(5), YARS2(8) 31619530 225 131 222 54 128 15 36 14 32 0 0.0603 1.000 1.000 223 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(9), ATM(65), BRCA1(23), CHEK1(3), CHEK2(11), GADD45A(1), JUN(4), MAPK8(5), MDM2(6), MRE11A(7), NFKB1(3), NFKBIA(6), RAD50(13), RAD51(7), RBBP8(11), RELA(6), TP73(6) 16711634 186 130 179 31 98 7 26 19 35 1 0.0540 1.000 1.000 224 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), ELK1(1), FPR1(3), GNA15(5), GNB1(7), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(3), MAPK3(8), NCF1(1), NCF2(6), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), NFKB1(3), NFKBIA(6), PAK1(4), PIK3C2G(11), PLCB1(17), PPP3CA(7), PPP3CB(7), PPP3CC(4), RAC1(4), RAF1(4), RELA(6), SYT1(6) 21890667 197 130 196 62 97 15 37 20 28 0 0.720 1.000 1.000 225 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(4), CANX(6), CD4(3), CD74(2), CD8A(2), CIITA(9), CTSB(6), CTSS(1), HLA-A(7), HLA-B(4), HLA-C(4), HLA-DMB(4), HLA-DOA(3), HLA-DOB(1), HLA-DPA1(6), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(5), HLA-F(5), HLA-G(3), HSP90AA1(27), HSP90AB1(11), HSPA5(11), IFI30(1), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL1(7), KIR3DL2(1), KLRC2(3), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(1), LTA(1), NFYA(2), NFYB(1), NFYC(1), PDIA3(6), PSME1(2), RFX5(6), RFXANK(1), RFXAP(2), TAP1(3), TAP2(2), TAPBP(4) 26881897 211 130 203 77 100 11 40 20 40 0 0.775 1.000 1.000 226 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(3), AKT2(5), AKT3(8), BAD(3), BCR(3), BLNK(8), BTK(5), CD19(4), CSK(7), DAG1(3), EPHB2(10), GRB2(3), ITPKA(4), ITPKB(5), LYN(5), MAP2K1(3), MAP2K2(5), NFAT5(15), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PI3(1), PIK3CD(7), PIK3R1(7), PLCG2(6), PPP1R13B(7), RAF1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SYK(8), VAV1(8) 29333999 214 130 212 69 105 7 48 27 27 0 0.690 1.000 1.000 227 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(29), AXIN1(4), CREBBP(50), CTNNB1(15), DVL1(5), FZD1(4), GSK3B(5), HDAC1(4), LDB1(3), LEF1(4), PITX2(7), TRRAP(40) 16400184 170 129 160 32 75 6 35 13 40 1 0.00724 1.000 1.000 228 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(7), APC(29), ATF2(1), AXIN1(4), BMP10(3), BMP2(1), BMP4(1), BMP5(6), BMP7(4), BMPR1A(3), BMPR2(9), CHRD(8), CTNNB1(15), DVL1(5), FZD1(4), GATA4(1), GSK3B(5), MAP3K7(8), MEF2C(5), MYL2(4), NKX2-5(5), NOG(2), NPPA(2), NPPB(1), RFC1(9), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10) 21144259 171 128 165 47 92 7 27 13 31 1 0.542 1.000 1.000 229 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(7), BID(2), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CFLAR(2), CHUK(7), CYCS(1), DFFA(6), DFFB(1), FADD(7), GAS2(3), LMNA(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), SPTAN1(68), TNFRSF10A(5), TNFRSF10B(6), TNFRSF25(3), TNFSF10(5), TRADD(2), TRAF2(5) 19334317 193 128 191 58 111 8 22 7 45 0 0.694 1.000 1.000 230 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(8), POLA2(11), POLD1(10), POLD2(3), POLD3(5), POLE(27), POLE2(4), POLE3(2), POLE4(1), POLG(8), POLG2(6), POLH(10), POLI(5), POLK(13), POLL(1), POLM(9), POLQ(28), PRIM2(1), REV1(8), REV3L(30), RFC5(5) 23539553 195 128 194 41 99 12 32 22 30 0 0.115 1.000 1.000 231 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(4), CRK(4), CRKL(1), DOCK1(11), ELK1(1), FOS(4), GAB1(7), GRB2(3), HGF(12), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP4K1(8), MAPK3(8), MAPK8(5), MET(19), PAK1(4), PIK3R1(7), PTK2(15), PTK2B(6), PTPN11(4), PXN(3), RAF1(4), RAP1A(1), RAP1B(2), RASA1(8), SOS1(23), SRC(5), STAT3(6) 23512549 197 128 192 46 102 10 36 22 27 0 0.149 1.000 1.000 232 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CDK5(3), F2(3), FYN(7), GNA11(3), GNAI1(4), GNB1(7), GRB2(3), JAK2(8), MAP2K1(3), MAP2K2(5), MAPK14(3), MAPK3(8), MAPK8(5), MAPT(10), MYLK(15), PLCG1(12), PRKCA(3), PTK2B(6), RAF1(4), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), SYT1(6) 23969708 199 127 196 83 102 10 37 23 27 0 0.985 1.000 1.000 233 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(6), F11(10), F12(3), F13B(9), F2(3), F5(24), F7(8), F8(22), F9(3), FGA(17), FGB(5), FGG(7), LPA(11), PLAT(6), PLAU(2), PLG(4), SERPINB2(3), SERPINE1(6), VWF(21) 20485546 170 127 167 48 85 8 39 20 18 0 0.430 1.000 1.000 234 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACADVL(2), ACAT1(5), ACAT2(1), ACOX1(7), ACOX3(7), ACSL1(3), ACSL3(2), ACSL4(2), ACSL5(6), ACSL6(2), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CPT1A(7), CPT1B(4), CPT1C(10), CPT2(5), CYP4A11(5), CYP4A22(7), ECHS1(1), EHHADH(6), GCDH(6), HADH(5), HADHA(4), HADHB(4), HSD17B10(1), HSD17B4(5) 28516176 175 127 173 64 90 8 31 13 33 0 0.769 1.000 1.000 235 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(8), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH7A1(1), ALDH9A1(7), AMDHD1(4), AOC2(5), AOC3(6), ASPA(2), CARM1(6), CNDP1(4), DDC(8), FTCD(4), HAL(7), HARS(6), HARS2(1), HDC(6), HEMK1(1), HNMT(3), LCMT1(2), LCMT2(12), MAOA(4), MAOB(2), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), PRPS1(3), PRPS2(1), UROC1(8), WBSCR22(7) 22963508 178 127 174 52 80 7 41 19 31 0 0.167 1.000 1.000 236 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(17), ANAPC11(1), ANAPC2(12), ANAPC4(8), ANAPC5(12), ANAPC7(6), BTRC(4), CDC16(4), CDC20(4), CDC23(1), CDC27(13), CUL1(19), CUL2(13), CUL3(9), FBXW11(1), FZR1(5), ITCH(12), RBX1(1), SKP1(7), SKP2(5), SMURF1(8), SMURF2(8), TCEB1(1), TCEB2(1), UBA1(1), UBE2C(5), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E1(1), UBE2E2(1), UBE2E3(1), VHL(2), WWP1(5), WWP2(5) 22356601 200 126 192 39 106 7 38 17 31 1 0.0607 1.000 1.000 237 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(18), ATP4B(2), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(14), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V1A(10), ATP6V1B1(8), ATP6V1B2(4), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1G3(4), ATP6V1H(7), ATP7A(7), ATP7B(9), COX10(4), COX5A(5), COX6A1(5), COX6C(2), COX7A1(1), COX7A2(3), COX7B(1), COX8A(1), NDUFA1(1), NDUFA10(5), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6), PPA2(2), SDHA(9), SDHB(2), SHMT1(3), UQCRB(1), UQCRC1(2), UQCRFS1(3), UQCRH(2) 22214490 198 126 192 53 106 8 39 20 25 0 0.133 1.000 1.000 238 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(11), EGF(17), EGFR(7), ELK1(1), FOS(4), GRB2(3), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1) 20323972 175 125 171 46 87 7 36 16 29 0 0.303 1.000 1.000 239 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(5), AZIN1(5), BTG1(3), CBX3(1), CEBPB(3), CLDN5(3), CLOCK(8), CRY1(3), CRY2(4), DAZAP2(5), DNAJA1(4), EIF4G2(10), ETV6(12), GFRA1(4), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(5), NCKAP1(12), NCOA4(6), NR1D2(10), PER1(6), PER2(6), PIGF(4), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(5), SF3A3(7), SUMO3(2), TOB1(5), TUBB3(5), UGP2(9), VAPA(6), ZFR(5) 21198935 193 124 186 58 99 11 33 18 32 0 0.808 1.000 1.000 240 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), AKR1B10(1), ALAS1(12), ALAS2(5), AMT(3), AOC2(5), AOC3(6), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), GNMT(3), HSD3B7(2), MAOA(4), MAOB(2), PEMT(1), PHGDH(3), PIPOX(4), PISD(3), PSAT1(6), PSPH(7), RDH12(2), RDH13(1), SARDH(4), SARS(5), SARS2(6), SDS(2), SHMT1(3), SHMT2(2), TARS(9), TARS2(14) 24615860 172 124 169 66 85 9 31 15 32 0 0.803 1.000 1.000 241 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(3), DAG1(3), DGKA(9), GCA(1), ITGA9(9), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), MAP2K1(3), MAPK3(8), NR1I3(4), PAK1(4), PDE3A(11), PDE3B(9), PI3(1), PIK3C2G(11), PIK3CD(7), PIK3R1(7), PSME1(2), RIPK3(6), RPS4X(4), SGCB(1), VASP(1) 26912665 184 124 181 82 92 11 36 15 30 0 0.994 1.000 1.000 242 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(1), ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), FUK(9), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), KHK(1), LHPP(2), MPI(7), MTMR1(8), MTMR2(6), MTMR6(8), PFKFB1(5), PFKFB2(3), PFKFB3(8), PFKL(2), PFKM(5), PFKP(4), PGM2(3), PMM1(6), PMM2(2), RDH12(2), RDH13(1), SORD(1), TPI1(1), TSTA3(2) 21450419 165 123 162 67 85 5 32 21 22 0 0.836 1.000 1.000 243 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(4), ACAA1(4), ACAA2(2), ACADM(1), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOX1(8), AUH(2), BCAT1(4), BCAT2(3), BCKDHA(4), BCKDHB(1), DBT(6), DLD(7), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HADHB(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), OXCT2(2), PCCA(4), PCCB(4) 25068080 173 123 170 54 99 8 20 19 27 0 0.678 1.000 1.000 244 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP1(2), INPP4A(3), INPP4B(10), INPP5A(6), INPPL1(11), ITPKA(4), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(16), PIK3C2B(18), PIK3C2G(11), PIK3CB(11), PIK3CG(10), PLCB1(17), PLCB2(6), PLCB3(11), PLCB4(10), PLCD1(6), PLCG1(12), PLCG2(6) 24624470 182 123 180 72 92 6 40 17 27 0 0.945 1.000 1.000 245 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), JAK1(9), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), PDGFRA(16), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4), STAT1(13), STAT3(6), STAT5A(1) 18824159 167 123 163 44 80 6 35 16 30 0 0.282 1.000 1.000 246 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(7), BAK1(2), BAX(2), BCL2L1(4), BID(2), BIRC2(3), BIRC3(3), CASP2(2), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), FADD(7), FAS(1), FASLG(1), GZMB(2), JUN(4), MAP2K4(4), MAP3K1(10), MAPK10(9), MCL1(2), MDM2(6), MYC(2), NFKB1(3), NFKBIA(6), PARP1(14), PRF1(7), RELA(6), RIPK1(7), TNF(4), TNFRSF1A(5), TNFRSF1B(6), TNFSF10(5), TRADD(2), TRAF2(5) 21196701 173 122 168 57 99 8 28 13 25 0 0.765 1.000 1.000 247 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH4A1(4), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(7), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), GOT1(2), MAOA(4), MAOB(2), NOS1(15), NOS3(11), OAT(1), ODC1(4), OTC(2), P4HA1(8), P4HA3(3), P4HB(6), PYCR1(3), RARS(6), SMS(1) 25549625 173 122 168 57 94 4 30 21 23 1 0.441 1.000 1.000 248 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(1), ARHGAP4(3), ARHGAP5(12), ARHGAP6(10), ARHGEF1(8), ARHGEF11(11), ARHGEF5(6), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), BAIAP2(5), CFL1(1), DIAPH1(5), GSN(2), LIMK1(6), MYL2(4), MYLK(15), OPHN1(8), PFN1(4), PIP5K1A(8), PIP5K1B(3), PPP1R12B(10), ROCK1(8), SRC(5), TLN1(17), VCL(4) 26229374 176 122 174 55 88 6 38 22 22 0 0.614 1.000 1.000 249 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(1), CDC42(4), DAXX(9), DDIT3(1), ELK1(1), GRB2(3), HMGN1(2), HSPB1(1), HSPB2(4), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K5(14), MAP3K7(8), MAP3K9(11), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MKNK1(6), MYC(2), PLA2G4A(1), RAC1(4), RIPK1(7), RPS6KA5(9), SHC1(8), STAT1(13), TGFB1(3), TGFB3(1), TGFBR1(7), TRADD(2), TRAF2(5) 20973244 167 121 166 58 89 9 32 11 25 1 0.903 1.000 1.000 250 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS1(12), ALAS2(5), AMT(3), AOC2(5), AOC3(6), ATP6V0C(3), BHMT(1), CBS(2), CHDH(5), CHKA(5), CHKB(4), CPT1B(4), CTH(5), DLD(7), DMGDH(5), GARS(6), GATM(3), GCAT(2), GLDC(8), MAOA(4), MAOB(2), PEMT(1), PISD(3), PLCB2(6), PLCG1(12), PLCG2(6), PSPH(7), SARDH(4), SARS(5), SHMT1(3), SHMT2(2), TARS(9) 24201048 159 120 156 59 78 7 33 12 29 0 0.717 1.000 1.000 251 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 21 ABL1(9), ATM(65), ATR(32), CCNA1(4), CCND1(4), CCNE1(3), CDC25A(5), CDK2(1), CDK4(6), CDK6(5), CDKN1B(6), CDKN2B(3), E2F1(3), GSK3B(5), HDAC1(4), SKP2(5), TFDP1(2), TGFB1(3), TGFB3(1) 15540450 166 119 160 33 81 8 26 20 29 2 0.0576 1.000 1.000 252 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(12), ALAS2(5), BLVRA(5), BLVRB(1), COX10(4), COX15(4), CP(5), CPOX(5), EARS2(3), EPRS(12), FECH(3), FTH1(8), FTMT(2), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), MMAB(2), PPOX(6), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), UROD(4), UROS(4) 24518901 173 119 171 57 83 7 25 25 33 0 0.795 1.000 1.000 253 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 31 GTF2A1(3), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F1(5), GTF2F2(2), GTF2H1(4), GTF2H3(5), GTF2H4(1), GTF2IRD1(9), STON1(13), TAF1(10), TAF10(1), TAF12(2), TAF13(2), TAF1L(21), TAF2(10), TAF4(6), TAF4B(6), TAF5(4), TAF5L(3), TAF6(8), TAF6L(6), TAF7(3), TAF7L(6), TAF9(7), TAF9B(2), TBPL1(2) 20290619 154 119 151 50 76 9 30 16 23 0 0.907 1.000 1.000 254 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(4), ACTN1(7), ACTN2(10), BCAR1(6), BCR(3), CAPN1(5), CAPNS2(1), CRKL(1), CSK(7), FYN(7), GRB2(3), ITGA1(7), ITGB1(3), JUN(4), MAP2K1(3), MAP2K2(5), MAPK3(8), MAPK8(5), PPP1R12B(10), PTK2(15), PXN(3), RAF1(4), RAP1A(1), ROCK1(8), SHC1(8), SOS1(23), SRC(5), TLN1(17), VCL(4), ZYX(4) 27076478 191 119 188 62 99 10 41 19 22 0 0.690 1.000 1.000 255 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(28), ACAT1(5), ACAT2(1), ADH5(1), AKR1B1(2), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), DLAT(6), DLD(7), GLO1(2), GRHPR(2), HAGH(2), LDHB(2), LDHC(4), LDHD(3), MDH1(3), ME1(5), ME2(1), ME3(6), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(2), PKLR(8) 21467689 155 117 152 57 83 3 32 15 22 0 0.838 1.000 1.000 256 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(11), ACTG2(2), ADCY3(5), ADCY9(8), AK1(1), ARF3(1), ARF4(1), ARF5(2), ARF6(1), ARL4D(1), ATP6V0A1(14), ATP6V0A2(6), ATP6V0A4(7), ATP6V0B(2), ATP6V0C(3), ATP6V0D1(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(10), ATP6V1C1(5), ATP6V1C2(3), ATP6V1D(3), ATP6V1E1(2), ATP6V1E2(4), ATP6V1G3(4), ATP6V1H(7), ERO1L(4), GNAS(12), PDIA4(5), PLCG1(12), PLCG2(6), PRKCA(3), SEC61A1(5), SEC61A2(7), TRIM23(5) 21561162 166 116 166 58 86 11 29 19 21 0 0.598 1.000 1.000 257 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), AKT2(5), AKT3(8), BAD(3), GRB2(3), GSK3A(2), GSK3B(5), IL4R(6), IRS1(9), IRS2(5), JAK1(9), JAK3(12), MAP4K1(8), MAPK3(8), PDK1(2), PIK3CD(7), PIK3R1(7), PPP1R13B(7), RAF1(4), SHC1(8), SOS1(23), SOS2(8), STAT6(9) 19964236 161 116 160 52 75 4 34 22 26 0 0.717 1.000 1.000 258 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(6), ALDOB(3), ALDOC(2), DLAT(6), DLD(7), ENO1(3), ENO2(2), ENO3(4), FBP1(3), FBP2(2), G6PC(2), GAPDH(3), GAPDHS(2), GCK(1), GOT1(2), GPI(4), HK1(15), HK2(11), HK3(8), LDHAL6B(2), LDHB(2), LDHC(4), MDH1(3), PC(10), PCK1(9), PDHA1(5), PDHA2(6), PDHB(2), PDHX(4), PFKL(2), PFKM(5), PFKP(4), PGAM1(1), PGAM2(4), PGK1(2), PKLR(8), TNFAIP1(2), TPI1(1) 24702421 162 115 160 75 79 5 42 16 20 0 0.970 1.000 1.000 259 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(4), ADC(6), ALDH4A1(4), CAD(16), CPS1(13), EARS2(3), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GFPT2(5), GLS(4), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), GMPS(5), GNPNAT1(3), GOT1(2), GPT(2), GPT2(1), GSR(2), GSS(7), NADSYN1(6), NAGK(5), PPAT(4), QARS(6) 22982504 160 115 157 59 81 11 34 16 18 0 0.819 1.000 1.000 260 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(3), ALOX12(2), ALOX12B(3), ALOX15(5), ALOX15B(3), ALOX5(4), CBR1(2), CBR3(1), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP2U1(2), CYP4A11(5), CYP4A22(7), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GPX6(3), GPX7(4), LTA4H(3), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3) 22520009 151 115 151 70 64 9 40 16 22 0 0.921 1.000 1.000 261 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(4), ARSD(7), ARSE(2), ASAH1(4), B4GALT6(2), CERK(2), DEGS1(3), ENPP7(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(3), SGMS2(4), SGPP1(3), SGPP2(2), SMPD1(7), SMPD2(2), SMPD3(5), SMPD4(9), SPHK1(1), SPHK2(11), SPTLC1(4), SPTLC2(5), UGCG(3), UGT8(6) 20576642 156 115 156 54 69 5 46 18 18 0 0.493 1.000 1.000 262 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(1), CHN1(3), LIMK1(6), MAP3K1(10), MYL2(4), MYLK(15), NCF2(6), PAK1(4), PDGFRA(16), PIK3R1(7), PLD1(9), PPP1R12B(10), RAC1(4), RALBP1(2), RPS6KB1(4), TRIO(36), VAV1(8), WASF1(5) 19054746 160 115 159 59 78 6 30 14 31 1 0.941 1.000 1.000 263 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ACSM1(2), AKR1B10(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BDH2(3), DDHD1(11), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADH(5), HADHA(4), HMGCL(1), HMGCS1(9), HMGCS2(7), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(3), L2HGDH(4), OXCT1(4), OXCT2(2), PDHA1(5), PDHA2(6), PDHB(2), PLA1A(3), PPME1(2), PRDX6(5), RDH12(2), RDH13(1) 23540402 155 114 154 63 83 10 24 19 19 0 0.939 1.000 1.000 264 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(4), AASDH(13), AASS(11), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ATP6V0C(3), BBOX1(4), DLST(1), DOT1L(21), ECHS1(1), EHHADH(6), EHMT1(8), EHMT2(12), GCDH(6), HADHA(4), PLOD1(3), PLOD2(5), PLOD3(5), SDS(2), SHMT1(3), SHMT2(2), TMLHE(2) 21430958 157 114 156 73 84 7 30 15 21 0 0.995 1.000 1.000 265 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(5), AKT3(8), DAG1(3), GNAQ(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PDK1(2), PHKA2(8), PIK3CB(11), PITX2(7), PLD1(9), PLD2(3), PLD3(5), VN1R1(2) 26038876 172 114 168 67 93 8 31 15 25 0 0.863 1.000 1.000 266 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 EGFR(7), ELK1(1), GNAS(12), GNB1(7), GRB2(3), IGF1R(11), ITGB1(3), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), MKNK1(6), MKNK2(3), MYC(2), NGFR(4), PDGFRA(16), PPP2CA(2), PTPRR(8), RAF1(4), RPS6KA1(5), RPS6KA5(9), SHC1(8), SOS1(23), SRC(5), STAT3(6) 19021277 162 113 160 54 81 7 38 22 14 0 0.738 1.000 1.000 267 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(6), CALM1(2), CALM2(2), ELK1(1), FOS(4), GNAI1(4), GNAQ(3), GNAS(12), GNB1(7), JUN(4), MAP2K1(3), MAPK3(8), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAF1(4), RPS6KA3(9), SYT1(6) 20057495 176 113 173 50 79 15 38 19 25 0 0.398 1.000 1.000 268 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(7), ATM(65), BAD(3), BAX(2), BCL2L1(4), BID(2), CASP3(3), CASP6(1), CASP7(5), CASP9(6), CYCS(1), EIF2S1(5), PRKCA(3), PTK2(15), PXN(3), STAT1(13), TLN1(17) 15471139 158 112 153 35 75 11 24 15 32 1 0.161 1.000 1.000 269 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(4), AKT1(3), AKT2(5), AKT3(8), BAD(3), BTK(5), DAPP1(2), GRB2(3), GSK3A(2), GSK3B(5), IARS(6), IGFBP1(4), INPP5D(5), PDK1(2), PPP1R13B(7), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), RPS6KB1(4), SFN(1), SHC1(8), SOS1(23), SOS2(8), TEC(10), YWHAB(2), YWHAE(3), YWHAG(4), YWHAH(2), YWHAQ(3), YWHAZ(6) 18836204 162 112 161 41 91 7 23 18 21 2 0.331 1.000 1.000 270 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(1), BCR(3), BLNK(8), ELK1(1), FOS(4), GRB2(3), JUN(4), LYN(5), MAP2K1(3), MAP3K1(10), MAPK3(8), MAPK8IP3(11), PAPPA(15), RAC1(4), RPS6KA1(5), RPS6KA3(9), SHC1(8), SOS1(23), SYK(8), VAV1(8), VAV2(8), VAV3(7) 18263479 156 110 153 49 81 3 35 20 17 0 0.622 1.000 1.000 271 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BAD(3), BRAF(9), CREB3(5), CREB5(11), DUSP4(3), DUSP6(7), DUSP9(3), EEF2K(7), EIF4E(2), GRB2(3), MAP2K1(3), MAP2K2(5), MAP3K8(5), MAPK3(8), MKNK1(6), MKNK2(3), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(5), RPS6KA2(10), RPS6KA3(9), SHC1(8), SOS1(23), SOS2(8), TRAF3(2) 17148106 156 110 154 45 79 5 28 19 25 0 0.614 1.000 1.000 272 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(3), AGTR1(3), ATF2(1), CALM1(2), CALM2(2), EGFR(7), ELK1(1), GNAQ(3), GRB2(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PAK1(4), PRKCA(3), PTK2(15), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6) 19173629 160 109 157 48 76 12 29 20 23 0 0.616 1.000 1.000 273 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(3), CABIN1(10), CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), HDAC5(6), IGF1(2), IGF1R(11), INSR(10), MAP2K6(1), MAPK14(3), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), NFATC1(14), NFATC2(13), PIK3R1(7), PPP3CA(7), PPP3CB(7), PPP3CC(4), SYT1(6), YWHAH(2) 18811109 141 109 141 53 63 11 30 12 25 0 0.831 1.000 1.000 274 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(9), EIF1(1), EIF2B1(1), EIF2B2(5), EIF2B3(1), EIF2B4(10), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), ELAVL1(7), FLT1(8), FLT4(10), HIF1A(6), KDR(19), NOS3(11), PIK3R1(7), PLCG1(12), PRKCA(3), PTK2(15), PXN(3), SHC1(8), VHL(2) 18214004 161 109 160 50 82 9 26 14 30 0 0.564 1.000 1.000 275 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(4), ACACA(28), ACACB(21), ACADM(1), ACAT1(5), ACAT2(1), ACSS1(7), ACSS2(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 23121877 144 108 143 49 74 6 22 19 23 0 0.711 1.000 1.000 276 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(3), BAD(3), BCL2L1(4), CBL(8), CFLAR(2), CRKL(1), E2F1(3), FOS(4), GRB2(3), IL2RA(1), IL2RB(2), IL2RG(5), IRS1(9), JAK1(9), JAK3(12), MAPK3(8), MYC(2), NMI(4), PIK3R1(7), PPIA(1), PTPN6(2), RAF1(4), RPS6KB1(4), SHC1(8), SOCS3(1), SOS1(23), STAT5A(1), STAT5B(5), SYK(8) 19441633 147 108 145 62 62 7 31 16 30 1 0.983 1.000 1.000 277 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), CYP2B6(8), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2D6(5), CYP2E1(4), CYP2F1(4), CYP2J2(2), CYP3A4(9), CYP3A5(4), CYP3A7(9), CYP4B1(5), CYP51A1(4), PON1(6) 17021974 150 107 145 63 74 10 35 13 18 0 0.724 1.000 1.000 278 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ARG2(3), ASL(7), ASS1(2), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), EPRS(12), GATM(3), GLUD1(6), GLUD2(10), GOT1(2), LAP3(4), NOS1(15), NOS3(11), OAT(1), OTC(2), P4HA1(8), P4HA3(3), PARS2(4), PRODH(3), PYCR1(3), PYCR2(1), PYCRL(3), RARS(6), RARS2(6) 20764080 154 107 147 47 92 7 26 12 16 1 0.417 1.000 1.000 279 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(4), ABAT(4), ACY3(8), ADSL(4), ADSS(4), ADSSL1(4), AGXT(2), AGXT2(2), ASL(7), ASNS(1), ASPA(2), ASRGL1(3), ASS1(2), CAD(16), CRAT(10), DARS(3), DARS2(10), DDO(1), DLAT(6), DLD(7), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(4), NARS2(7), PC(10), PDHA1(5), PDHA2(6), PDHB(2) 21969274 157 106 155 56 87 9 31 12 18 0 0.763 1.000 1.000 280 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(7), CREBBP(50), DUSP1(3), IKBKB(11), IL1B(3), MAP2K3(6), MAP2K6(1), MAP3K7(8), MAPK11(5), MAPK14(3), MYD88(2), NFKB1(3), NFKBIA(6), NR3C1(6), RELA(6), TGFBR1(7), TGFBR2(8), TLR2(3), TNF(4) 14303468 142 106 138 36 57 5 24 8 46 2 0.333 1.000 1.000 281 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(3), AKT2(5), AKT3(8), CISH(1), GRB2(3), IARS(6), IL13RA1(2), IL2RG(5), IL4R(6), INPP5D(5), JAK1(9), JAK2(8), JAK3(12), NR0B2(2), PI3(1), PPP1R13B(7), RPS6KB1(4), SERPINA4(2), SHC1(8), SOS1(23), SOS2(8), SRC(5), STAT6(9), TYK2(9) 20098028 151 106 150 48 75 4 31 19 21 1 0.658 1.000 1.000 282 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(2), CDC42(4), CREB3(5), CREB5(11), DUSP1(3), DUSP10(4), EEF2K(7), EIF4E(2), ELK1(1), GADD45A(1), HSPB1(1), IL1R1(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K10(2), MAP3K4(20), MAP3K5(14), MAP3K7(8), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MKNK1(6), MKNK2(3), MYEF2(5), NFKB1(3), NR2C2(7), SRF(4), TRAF6(1) 19295118 146 106 144 48 73 7 32 13 21 0 0.762 1.000 1.000 283 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(4), ACAA2(2), ACADL(2), ACADM(1), ACADS(6), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOX1(8), BCAT1(4), BCKDHA(4), BCKDHB(1), ECHS1(1), EHHADH(6), HADHA(4), HADHB(4), HMGCL(1), IVD(2), MCCC1(12), MCCC2(8), MCEE(3), MUT(9), OXCT1(4), PCCA(4), PCCB(4), SDS(2) 20998937 140 106 137 55 79 8 16 15 22 0 0.962 1.000 1.000 284 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(11), FOS(4), GRB2(3), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MPL(7), PIK3R1(7), PLCG1(12), PRKCA(3), RAF1(4), RASA1(8), SHC1(8), SOS1(23), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), THPO(6) 15978827 144 105 140 38 79 7 21 12 25 0 0.364 1.000 1.000 285 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(9), CALCRL(8), CD97(5), CRHR1(4), CRHR2(3), ELTD1(10), EMR1(6), EMR2(6), GHRHR(5), GIPR(3), GLP1R(3), GLP2R(3), GPR64(7), LPHN1(9), LPHN2(23), LPHN3(21), SCTR(4), VIPR1(1), VIPR2(4) 15363566 141 104 141 67 52 7 41 15 26 0 0.940 1.000 1.000 286 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(10), ACO1(4), ACO2(5), CLYBL(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), OGDH(21), OGDHL(10), PC(10), PCK1(9), PCK2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 17417733 142 104 138 57 77 4 31 13 17 0 0.836 1.000 1.000 287 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(3), CHUK(7), ELK1(1), FOS(4), IKBKB(11), IRAK1(3), JUN(4), LY96(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(3), MAPK8(5), MYD88(2), NFKB1(3), NFKBIA(6), PPARA(1), RELA(6), TLR10(12), TLR2(3), TLR3(10), TLR4(6), TLR6(6), TLR7(9), TLR9(12), TOLLIP(3), TRAF6(1) 21134052 151 104 149 49 79 8 24 11 29 0 0.700 1.000 1.000 288 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(21), BAIAP2(5), CASP1(9), CASP3(3), CASP7(5), CASP8(14), GAPDH(3), INSR(10), ITCH(12), MAGI1(15), MAGI2(17), RERE(16), WWP1(5), WWP2(5) 13988690 140 103 136 37 80 4 27 13 16 0 0.302 1.000 1.000 289 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(6), CALM1(2), CALM2(2), CRKL(1), GNAQ(3), GRB2(3), JUN(4), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K4(4), MAP3K1(10), MAPK14(3), MAPK3(8), MAPK8(5), PAK1(4), PLCG1(12), PRKCA(3), PTK2B(6), RAC1(4), RAF1(4), SHC1(8), SOS1(23), SRC(5), SYT1(6) 16305512 140 103 137 46 71 7 28 15 19 0 0.757 1.000 1.000 290 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), AOX1(8), COMT(3), DBH(4), DCT(9), DDC(8), FAH(3), GOT1(2), GSTZ1(2), HGD(4), HPD(4), MAOA(4), MAOB(2), TAT(5), TH(2), TPO(16), TYR(12) 18344190 141 103 141 43 59 3 40 14 25 0 0.227 1.000 1.000 291 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(7), ACTN2(10), CAPN1(5), CAPNS2(1), ITGA1(7), ITGB1(3), ITGB3(9), PTK2(15), PXN(3), RAC1(4), SPTAN1(68), SRC(5), TLN1(17) 16549937 158 103 157 43 79 7 24 9 39 0 0.284 1.000 1.000 292 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(5), AKR1D1(5), ARSB(8), ARSD(7), ARSE(2), CYP11B1(6), CYP11B2(13), HSD11B2(3), HSD17B2(6), HSD17B3(1), HSD17B8(4), HSD3B1(5), HSD3B2(5), SRD5A1(5), STS(5), SULT1E1(1), SULT2A1(4), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4) 15863593 127 102 127 35 61 8 30 16 12 0 0.163 1.000 1.000 293 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(3), CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), IL6(4), IL6R(4), IL6ST(9), JAK1(9), JAK2(8), JAK3(12), JUN(4), MAP2K1(3), MAPK3(8), PTPN11(4), RAF1(4), SHC1(8), SOS1(23), SRF(4), STAT3(6) 13599593 132 101 129 28 70 5 22 17 18 0 0.0565 1.000 1.000 294 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(3) 13350597 140 100 136 41 50 6 36 14 33 1 0.399 1.000 1.000 295 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(6), CD3E(2), CD3G(2), CD4(3), CREBBP(50), CSK(7), GNAS(12), GNB1(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTPRC(19), ZAP70(3) 13350597 140 100 136 41 50 6 36 14 33 1 0.399 1.000 1.000 296 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(12), DIAPH1(5), FYN(7), GSN(2), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), MYL2(4), MYLK(15), PFN1(4), PIK3R1(7), PTK2(15), PXN(3), RAF1(4), ROCK1(8), SHC1(8), SRC(5), TLN1(17) 20235402 137 100 137 38 64 6 30 18 19 0 0.487 1.000 1.000 297 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(8), FUCA1(2), FUCA2(6), GALNS(3), GBA(4), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), MAN2B1(9), MAN2B2(7), MAN2C1(8), MANBA(5), NAGLU(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5), SPAM1(2) 19832019 133 100 132 43 71 3 26 19 14 0 0.387 1.000 1.000 298 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(4), ACAA2(2), ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), AKR1B10(1), AKR1C4(5), AKR1D1(5), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), HSD3B7(2), LIPA(3), RDH12(2), RDH13(1), SLC27A5(9), SOAT1(5), SOAT2(1), SRD5A1(5) 18295273 137 99 131 47 69 8 27 10 23 0 0.428 1.000 1.000 299 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(3), EIF4A1(4), EIF4A2(11), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), GHR(6), IRS1(9), MAPK14(3), MAPK3(8), MKNK1(6), PABPC1(7), PDK2(2), PDPK1(2), PIK3R1(7), PRKCA(3), RPS6KB1(4) 14684703 132 98 131 44 57 8 30 13 23 1 0.933 1.000 1.000 300 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(50), FYN(7), IL2RG(5), IL7(1), IL7R(7), JAK1(9), JAK3(12), LCK(2), NMI(4), PIK3R1(7), PTK2B(6), STAT5A(1), STAT5B(5) 12018329 116 98 113 35 31 4 30 11 39 1 0.495 1.000 1.000 301 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(8), EGF(17), EGFR(7), GRB2(3), MAP2K1(3), MAPK3(8), PTPRB(17), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SPRY1(3), SPRY2(5), SPRY3(3), SPRY4(5), SRC(5) 14284640 127 98 126 34 67 6 28 14 12 0 0.373 1.000 1.000 302 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(6), CHIA(7), CHIT1(7), CMAS(2), CTBS(2), CYB5R1(4), CYB5R3(4), GFPT1(5), GFPT2(5), GNE(8), GNPDA1(3), GNPDA2(2), GNPNAT1(3), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), NAGK(5), NPL(2), PGM3(2), RENBP(4), UAP1(5) 16623480 139 97 138 48 76 7 26 15 15 0 0.752 1.000 1.000 303 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(4), CDK7(6), ERCC3(7), GTF2A2(1), GTF2B(2), GTF2E1(7), GTF2E2(3), GTF2F2(2), GTF2H1(4), GTF2H4(1), ILK(3), MNAT1(4), POLR1A(18), POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3B(6), POLR3D(1), POLR3E(4), POLR3H(2), TAF12(2), TAF13(2), TAF5(4), TAF6(8), TAF7(3), TAF9(7), TBP(2) 20384628 145 97 143 56 87 8 17 12 21 0 0.971 1.000 1.000 304 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(1), B4GALT1(4), B4GALT2(1), G6PC(2), G6PC2(2), GAA(5), GALE(2), GALK1(2), GALT(1), GANC(7), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), HSD3B7(2), LCT(16), MGAM(16), PFKL(2), PFKM(5), PFKP(4), PGM1(3), PGM3(2), RDH12(2), RDH13(1), UGP2(9) 22312520 134 96 131 68 69 5 26 14 20 0 0.989 1.000 1.000 305 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(29), ASAH1(4), CAMP(1), CASP3(3), CERK(2), CREB3(5), CREB5(11), CXCL2(1), DAG1(3), EPHB2(10), FOS(4), GNAQ(3), ITPKA(4), ITPKB(5), JUN(4), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5) 16506815 132 96 129 41 65 4 30 12 21 0 0.644 1.000 1.000 306 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(6), AKT1(3), ASAH1(4), GNAI1(4), GNB1(7), ITGAV(13), ITGB3(9), MAPK3(8), PDGFRA(16), PIK3R1(7), PLCB1(17), PRKCA(3), PTK2(15), RAC1(4), SMPD1(7), SMPD2(2), SPHK1(1), SRC(5) 14705479 131 95 130 36 61 9 29 15 17 0 0.251 1.000 1.000 307 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(4), ALDH4A1(4), CAD(16), CPS1(13), EPRS(12), GAD1(8), GAD2(6), GCLC(6), GCLM(2), GFPT1(5), GLS(4), GLS2(4), GLUD1(6), GLUL(3), GMPS(5), GOT1(2), GPT(2), GPT2(1), GSS(7), NADSYN1(6), PPAT(4), QARS(6) 19339820 126 95 125 50 63 10 24 13 16 0 0.923 1.000 1.000 308 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), IGF1(2), IGF1R(11), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3R1(7), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SOS1(23), SRF(4) 12895596 119 95 116 29 60 3 23 17 16 0 0.232 1.000 1.000 309 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(1), ADRA1D(5), ADRA2A(3), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(5), CHRM3(8), CHRM4(2), CHRM5(3), DRD1(2), DRD2(5), DRD3(1), DRD4(1), DRD5(2), HRH1(9), HRH2(1), HTR1A(9), HTR1B(4), HTR1D(6), HTR1E(2), HTR1F(7), HTR2A(2), HTR2B(5), HTR2C(1), HTR4(6), HTR5A(3), HTR6(5), HTR7(5) 14857312 119 95 116 67 59 5 34 11 10 0 0.847 1.000 1.000 310 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(4), ACACA(28), ACADL(2), ACADM(1), ACADSB(3), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), LDHB(2), LDHC(4), MCEE(3), MLYCD(2), MUT(9), PCCA(4), PCCB(4), SDS(2), SUCLA2(2), SUCLG1(2), SUCLG2(3) 19322692 127 95 126 45 68 5 19 16 19 0 0.855 1.000 1.000 311 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(2), CHUK(7), EGR2(3), EGR3(3), GNAQ(3), MAP3K1(10), MYC(2), NFATC1(14), NFATC2(13), NFKB1(3), NFKBIA(6), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RELA(6), SYT1(6), VIPR2(4) 16257616 136 95 136 44 64 12 29 8 23 0 0.658 1.000 1.000 312 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(6), AKT1(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), GNAS(12), GRB2(3), MAPK14(3), MAPK3(8), PIK3R1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), RAC1(4), RPS6KA1(5), RPS6KA5(9), SOS1(23) 15423942 127 94 126 47 70 3 26 13 15 0 0.884 1.000 1.000 313 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(3), ARRB2(4), CALM1(2), CALM2(2), CALML3(1), CALML6(3), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CLCA1(8), CLCA2(5), CLCA4(12), CNGA3(4), CNGB1(13), GNAL(4), GUCA1B(1), GUCA1C(2), PDE1C(15), PRKACA(2), PRKACB(4), PRKACG(2), PRKG1(10), PRKG2(8), PRKX(1) 17727032 130 94 130 57 67 5 24 14 20 0 0.969 1.000 1.000 314 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(4), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SDS(2), SMS(1), UPB1(4) 16930150 121 93 120 47 54 9 25 18 15 0 0.884 1.000 1.000 315 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(3), GHR(6), GRB2(3), INSR(10), IRS1(9), JAK2(8), MAP2K1(3), MAPK3(8), PIK3R1(7), PLCG1(12), PRKCA(3), PTPN6(2), RAF1(4), RPS6KA1(5), SHC1(8), SLC2A4(4), SOS1(23), SRF(4), STAT5A(1), STAT5B(5) 17779015 128 93 127 53 67 3 26 14 18 0 0.949 1.000 1.000 316 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), INSR(10), IRS1(9), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PIK3R1(7), PTPN11(4), RAF1(4), RASA1(8), SHC1(8), SLC2A4(4), SOS1(23), SRF(4) 13265603 120 93 117 37 65 3 21 16 15 0 0.602 1.000 1.000 317 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(16), C5(9), C6(9), C7(4), ICAM1(7), IL1A(1), IL6(4), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELP(7), SELPLG(3), TNF(4), VCAM1(14) 14431991 124 93 124 42 66 7 25 11 15 0 0.668 1.000 1.000 318 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(2), DLG4(6), GRIN1(9), GRIN2A(14), GRIN2B(10), GRIN2C(11), GRIN2D(9), NOS1(15), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3), SYT1(6) 14795900 127 93 124 43 49 12 31 17 17 1 0.511 1.000 1.000 319 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(16), AKT1(3), ATM(65), BAX(2), CPB2(5), CSNK1A1(6), CSNK1D(3), FHL2(4), GADD45A(1), HIF1A(6), HSPA1A(3), IGFBP3(1), MAPK8(5), MDM2(6), NFKBIB(6) 11410857 132 93 128 29 59 8 21 16 27 1 0.266 1.000 1.000 320 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(3), CFL1(1), GNAQ(3), GNAS(12), GNB1(7), LIMK1(6), MAP2K1(3), MAPK3(8), MYL2(4), NOX1(4), PIK3C2G(11), PLCB1(17), PPP1R12B(10), PRKCA(3), PTK2(15), RAF1(4), ROCK2(15) 14329104 126 92 124 38 69 8 22 17 10 0 0.707 1.000 1.000 321 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), FPGT(10), GCK(1), GMDS(6), GMPPA(3), GMPPB(5), HK1(15), HK2(11), HK3(8), KHK(1), MPI(7), PFKFB1(5), PFKFB3(8), PFKM(5), PFKP(4), PMM1(6), PMM2(2), SORD(1), TPI1(1) 13797654 117 92 114 50 59 4 24 14 16 0 0.827 1.000 1.000 322 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), IL2(1), IL2RA(1), IL2RB(2), IL2RG(5), JAK1(9), JAK3(12), JUN(4), LCK(2), MAP2K1(3), MAPK3(8), MAPK8(5), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5), SYK(8) 13196748 120 92 117 40 54 5 27 17 17 0 0.617 1.000 1.000 323 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(2), ALOX15(5), ALOX5(4), CBR1(2), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(6), GGT1(5), LPO(8), LTA4H(3), MPO(4), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PRDX1(5), PRDX2(5), PRDX5(2), PRDX6(5), PTGDS(1), PTGES2(2), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3), TPO(16) 16145160 124 92 123 47 59 5 30 11 18 1 0.564 1.000 1.000 324 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), DAG1(3), ITPKA(4), ITPKB(5), ITPR1(21), ITPR2(33), ITPR3(9), NFAT5(15), PDE6A(4), PDE6B(5), PDE6C(5), PDE6H(1), SLC6A13(2), TF(4) 20732514 130 92 128 64 76 5 23 9 17 0 0.993 1.000 1.000 325 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(3), APC(29), AXIN1(4), CCND1(4), CD14(3), CTNNB1(15), DVL1(5), FZD1(4), GJA1(3), GNAI1(4), GSK3B(5), IRAK1(3), LBP(2), LEF1(4), LY96(1), MYD88(2), NFKB1(3), PDPK1(2), PIK3R1(7), PPP2CA(2), RELA(6), TLR4(6), TOLLIP(3) 16522966 120 91 115 37 62 3 23 6 26 0 0.747 1.000 1.000 326 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(4), CAPN1(5), CAPN2(2), CAPNS2(1), CXCR3(3), EGF(17), EGFR(7), ITGA1(7), ITGB1(3), MAPK3(8), MYL2(4), MYLK(15), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PTK2(15), PXN(3), TLN1(17) 18700675 133 91 133 47 61 11 32 11 18 0 0.760 1.000 1.000 327 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(4), B4GALT2(1), FBP2(2), G6PC(2), GAA(5), GALE(2), GALK1(2), GALT(1), GANAB(16), GCK(1), GLA(3), GLB1(5), HK1(15), HK2(11), HK3(8), LCT(16), MGAM(16), PFKM(5), PFKP(4), PGM1(3), PGM3(2) 18802492 126 90 125 59 64 4 28 12 18 0 0.959 1.000 1.000 328 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 DUSP1(3), GORASP1(2), MAP2K4(4), MAP2K7(3), MAPK10(9), MAPK11(5), MAPK12(2), MAPK13(3), MAPK14(3), MAPK3(8), MAPK8(5), MAPK8IP1(5), MAPK8IP2(1), MAPK8IP3(11), MAPK9(5), MAPKAPK5(3), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), PIK3CD(7), PIK3R1(7), SYT1(6), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1) 18086560 127 90 126 43 62 10 28 9 18 0 0.627 1.000 1.000 329 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(4), ACAA2(2), ADH1A(5), ADH1B(3), ADH4(2), ADH6(7), ADH7(4), ADHFE1(4), AKR1C4(5), AKR1D1(5), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), BAAT(3), CEL(8), CYP27A1(9), CYP7A1(10), HADHB(4), SOAT2(1), SRD5A1(5) 13483670 116 89 111 32 53 8 26 10 19 0 0.154 1.000 1.000 330 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(7), GPRC5A(2), GPRC5B(1), GPRC5C(3), GPRC5D(1), GRM1(22), GRM2(10), GRM3(10), GRM4(9), GRM5(19), GRM7(12), GRM8(8) 12244303 110 89 109 46 46 6 31 13 14 0 0.591 1.000 1.000 331 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(3), DLAT(6), DLD(7), DLST(1), FH(7), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), OGDH(21), PC(10), PDHA1(5), PDHA2(6), PDHB(2), PDHX(4), PDK1(2), PDK2(2), PDK3(1), PDK4(1), PDP2(2), SDHA(9), SDHB(2), SDHC(2), SDHD(4), SUCLA2(2), SUCLG1(2), SUCLG2(3) 16514949 124 89 119 43 67 5 29 10 13 0 0.698 1.000 1.000 332 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(7), APC(29), AXIN1(4), BTRC(4), CTNNB1(15), DLL1(9), DVL1(5), FZD1(4), GSK3B(5), NOTCH1(17), PSEN1(8) 12262160 107 89 103 27 56 3 21 4 21 2 0.437 1.000 1.000 333 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(4), BIRC2(3), BIRC3(3), CASP3(3), CASP8(14), CFLAR(2), FADD(7), JUN(4), MAP2K4(4), MAP3K3(3), MAP3K7(8), NFKB1(3), NFKB2(3), NFKBIA(6), NFKBIB(6), NFKBIE(7), NFKBIL1(1), NR2C2(7), RALBP1(2), RIPK1(7), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF2(5) 15779448 126 89 121 34 78 5 17 8 18 0 0.277 1.000 1.000 334 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(4), ARSB(8), ARSD(7), ARSE(2), ASAH1(4), GAL3ST1(5), GALC(4), GBA(4), GLA(3), GLB1(5), LCT(16), NEU1(2), NEU2(3), NEU3(7), NEU4(5), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(7), SMPD2(2), SPTLC1(4), SPTLC2(5), UGCG(3) 13934575 109 88 109 34 52 5 26 14 12 0 0.396 1.000 1.000 335 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(6), AP2M1(2), BIN1(5), CALM1(2), CALM2(2), DNM1(13), EPN1(1), EPS15(10), NME1(1), NME2(3), PICALM(8), PPP3CA(7), PPP3CB(7), PPP3CC(4), SYNJ1(20), SYNJ2(8), SYT1(6) 12615416 111 88 111 32 60 5 13 14 19 0 0.610 1.000 1.000 336 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1(4), CSF1R(11), DDX20(10), E2F1(3), E2F4(2), ETS1(5), ETS2(5), ETV3(1), FOS(4), HDAC2(3), HDAC5(6), JUN(4), NCOR2(19), RBL1(9), RBL2(9), SIN3A(12), SIN3B(5) 14710093 112 87 110 35 56 1 24 13 18 0 0.517 1.000 1.000 337 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(3), BCR(3), CRKL(1), FOS(4), GRB2(3), JAK2(8), JUN(4), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), MYC(2), PIK3R1(7), RAF1(4), SOS1(23), STAT1(13), STAT5A(1), STAT5B(5) 14842617 111 86 107 39 58 4 16 10 23 0 0.881 1.000 1.000 338 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH3B1(4), ALDH3B2(5), ALDH9A1(7), AOC2(5), AOC3(6), ASPA(2), CNDP1(4), DDC(8), HAL(7), HARS(6), HDC(6), HNMT(3), MAOA(4), MAOB(2), PRPS1(3), PRPS2(1) 14173380 101 86 100 33 41 4 28 10 18 0 0.440 1.000 1.000 339 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(7), IFNA1(1), IFNB1(1), IKBKB(11), IL1A(1), IL1B(3), IL1R1(1), IL1RAP(5), IL1RN(1), IL6(4), IRAK1(3), IRAK2(5), IRAK3(9), JUN(4), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAP3K7(8), MAPK14(3), MAPK8(5), MYD88(2), NFKB1(3), NFKBIA(6), RELA(6), TGFB1(3), TGFB3(1), TNF(4), TOLLIP(3), TRAF6(1) 17179234 118 86 116 39 64 3 17 9 25 0 0.727 1.000 1.000 340 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(3), EIF4A1(4), EIF4A2(11), EIF4B(4), EIF4E(2), EIF4EBP1(1), EIF4G1(17), EIF4G2(10), EIF4G3(27), FKBP1A(1), MKNK1(6), PDK2(2), PDPK1(2), PIK3R1(7), PPP2CA(2), RPS6(5), RPS6KB1(4), TSC2(11) 12888351 119 86 118 37 51 8 28 9 22 1 0.826 1.000 1.000 341 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(6), EPHB2(10), F2(3), F2RL1(5), F2RL2(2), F2RL3(2), JUN(4), MAP2K5(4), MAPK7(3), MAPK8(5), MYEF2(5), PLD1(9), PLD2(3), PLD3(5), PTK2(15), RAF1(4), RASAL1(8), SRC(5), TEC(10), VAV1(8) 15908002 121 86 119 43 58 12 21 15 15 0 0.754 1.000 1.000 342 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(6), CBS(2), CTH(5), GGT1(5), HEMK1(1), LCMT1(2), LCMT2(12), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), METTL2B(3), METTL6(5), PAPSS1(4), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), SCLY(2), SEPHS1(2), SEPHS2(1), WBSCR22(7) 14482008 101 85 97 38 55 4 22 9 11 0 0.719 1.000 1.000 343 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 ERCC3(7), GTF2A1(3), GTF2B(2), GTF2E1(7), GTF2F1(5), HDAC3(1), NCOA1(25), NCOA2(12), NCOA3(16), NCOR2(19), POLR2A(13), RARA(6), TBP(2) 13867753 118 85 115 39 66 3 22 8 19 0 0.800 1.000 1.000 344 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(11), ELK1(1), EPO(2), EPOR(5), FOS(4), GRB2(3), JAK2(8), JUN(4), MAP2K1(3), MAPK3(8), MAPK8(5), PLCG1(12), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5) 12256623 109 84 106 32 61 5 15 12 16 0 0.479 1.000 1.000 345 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(5), DARS(3), EPRS(12), FARS2(1), GARS(6), HARS(6), IARS(6), KARS(11), LARS(11), LARS2(3), MARS(3), MARS2(5), NARS(4), QARS(6), RARS(6), SARS(5), TARS(9), WARS(5), WARS2(2), YARS(5) 18745148 118 83 118 39 70 6 17 8 17 0 0.734 1.000 1.000 346 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GPX6(3), GPX7(4), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(3), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), OPLAH(4), TXNDC12(2) 12766161 105 83 105 47 48 4 26 8 19 0 0.875 1.000 1.000 347 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(5), ALOX5(4), CYP1A2(4), CYP2C18(5), CYP2C19(7), CYP2C8(5), CYP2C9(3), CYP2E1(4), CYP2J2(2), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), HSD3B7(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), RDH12(2), RDH13(1) 13924185 97 83 97 40 44 4 21 12 16 0 0.801 1.000 1.000 348 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(13), APOA1(2), APOA4(4), APOC1(1), APOC2(1), APOC3(1), APOE(2), CETP(2), CYP7A1(10), DGAT1(3), HMGCR(7), LCAT(3), LDLR(10), LIPC(6), LPL(4), LRP1(36), SCARB1(3), SOAT1(5) 15957453 113 83 113 46 57 5 22 10 19 0 0.806 1.000 1.000 349 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(11), EGF(17), EGFR(7), GRB2(3), MET(19), PDGFRA(16), PRKCA(3), SH3GLB1(1), SH3GLB2(1), SH3KBP1(8), SRC(5) 11321290 99 82 98 38 42 5 30 12 10 0 0.888 1.000 1.000 350 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(3), BAX(2), CASP8(14), CYCS(1), FADD(7), MAP2K1(3), MAP2K4(4), MAP3K1(10), MAPK3(8), MAPK8(5), NFKB1(3), NSMAF(12), RAF1(4), RELA(6), RIPK1(7), SMPD1(7), TNFRSF1A(5), TRADD(2), TRAF2(5) 11874769 108 82 105 30 60 4 11 11 22 0 0.385 1.000 1.000 351 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(4), ACADM(1), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), CNDP1(4), DPYD(14), DPYS(13), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), MLYCD(2), SMS(1), SRM(3), UPB1(4) 15706845 106 82 106 39 45 8 22 16 15 0 0.796 1.000 1.000 352 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CDK2(1), CDK4(6), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2) 8768849 106 82 103 23 49 6 14 13 23 1 0.325 1.000 1.000 353 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(7), ARHGDIB(1), BIRC2(3), BIRC3(3), CASP1(9), CASP10(1), CASP2(2), CASP3(3), CASP4(5), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DFFB(1), GZMB(2), LMNA(5), LMNB1(4), LMNB2(7), PRF1(7) 11239631 93 81 93 34 53 4 16 7 13 0 0.920 1.000 1.000 354 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(6), ALDH3B1(4), ALDH3B2(5), AOC2(5), AOC3(6), DDC(8), EPX(6), ESCO1(3), ESCO2(3), GOT1(2), HPD(4), LPO(8), MAOA(4), MAOB(2), MIF(1), MPO(4), NAT6(1), PNPLA3(4), PRDX6(5), SH3GLB1(1), TAT(5), TPO(16) 19882147 105 81 105 27 47 4 30 9 15 0 0.166 1.000 1.000 355 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), C1GALT1(4), C1GALT1C1(3), GALNT1(5), GALNT10(3), GALNT11(4), GALNT12(4), GALNT13(5), GALNT14(3), GALNT2(8), GALNT3(5), GALNT5(6), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GALNTL5(8), GCNT1(5), GCNT3(3), GCNT4(5), OGT(5), ST3GAL1(1), ST3GAL2(3), ST6GALNAC1(8), WBSCR17(9) 18825856 116 81 116 35 55 8 28 11 14 0 0.501 1.000 1.000 356 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(10), ABCC2(12), ABCG2(10), BCHE(9), CES1(4), CES2(7), CYP3A4(9), CYP3A5(4), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3) 13357273 97 81 97 31 47 4 23 11 12 0 0.404 1.000 1.000 357 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(5), BLVRB(1), CP(5), CPOX(5), EPRS(12), FECH(3), GUSB(3), HCCS(3), HMOX1(3), HMOX2(2), PPOX(6), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4), UROD(4), UROS(4) 15967504 103 81 103 39 47 4 18 14 20 0 0.919 1.000 1.000 358 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(4), ACADS(6), ACAT1(5), ACAT2(1), ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), GAD1(8), GAD2(6), HADHA(4), HMGCL(1), L2HGDH(4), OXCT1(4), PDHA1(5), PDHA2(6), PDHB(2), SDHB(2), SDS(2) 15013646 104 80 103 48 54 6 17 13 14 0 0.982 1.000 1.000 359 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(2), CALM2(2), GNAQ(3), MARCKS(2), NFATC1(14), NFATC2(13), NFATC3(14), NFATC4(5), PLCG1(12), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), SP1(10), SP3(3), SYT1(6) 12025717 107 80 107 35 51 11 21 10 14 0 0.745 1.000 1.000 360 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(7), FADD(7), IKBKB(11), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(10), MAP3K7(8), MYD88(2), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TLR4(6), TNF(4), TNFAIP3(7), TNFRSF1A(5), TNFRSF1B(6), TRADD(2), TRAF6(1) 14056195 103 80 101 29 59 3 13 5 23 0 0.495 1.000 1.000 361 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(49), MAP2(16), PPP1CA(8), PPP2CA(2), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5), PRKCE(5) 10617251 99 79 97 19 58 4 13 15 9 0 0.259 1.000 1.000 362 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(6), CRK(4), CXCL12(6), CXCR4(4), GNAI1(4), GNAQ(3), GNB1(7), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3C2G(11), PIK3R1(7), PLCG1(12), PRKCA(3), PTK2(15), PTK2B(6), PXN(3), RAF1(4), RELA(6) 14406863 115 79 114 32 59 11 19 12 14 0 0.306 1.000 1.000 363 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(6), ARHGEF1(8), F2(3), F2R(2), F2RL3(2), GNA12(3), GNA13(12), GNAI1(4), GNAQ(3), GNB1(7), MAP3K7(8), PIK3R1(7), PLCB1(17), PPP1R12B(10), PRKCA(3), PTK2B(6), ROCK1(8) 13712625 109 79 102 36 60 5 17 12 15 0 0.696 1.000 1.000 364 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(3), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(6), ILVBL(3), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCDC(1), PPCS(9), UPB1(4), VNN1(3) 10082732 95 78 91 41 43 5 20 17 10 0 0.968 1.000 1.000 365 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(2), MRPL13(2), MRPS7(5), RPL10A(3), RPL10L(3), RPL11(2), RPL13(3), RPL19(2), RPL22L1(2), RPL23A(4), RPL24(4), RPL26(1), RPL28(3), RPL29(2), RPL3(1), RPL30(1), RPL31(5), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL3L(3), RPL41(1), RPL6(2), RPL7(3), RPL8(2), RPL9(1), RPS12(3), RPS13(2), RPS16(4), RPS18(6), RPS2(6), RPS20(2), RPS24(1), RPS26(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1), RPS5(1), RPS6(5), RPS7(2), RPS8(2), RPS9(3), RPSA(4) 13137032 108 78 107 40 55 9 26 5 13 0 0.552 1.000 1.000 366 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(3), F2R(2), F2RL3(2), GNAI1(4), GNB1(7), ITGA1(7), ITGB1(3), MAP2K1(3), MAPK3(8), PLA2G4A(1), PLCB1(17), PRKCA(3), PTGS1(2), PTK2(15), RAF1(4), SRC(5), SYK(8), TBXAS1(3) 13922391 97 78 96 42 46 9 20 12 10 0 0.976 1.000 1.000 367 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(2), CHUK(7), CRADD(1), IKBKB(11), JUN(4), LTA(1), MAP2K3(6), MAP2K4(4), MAP2K6(1), MAP3K1(10), MAP4K2(5), MAPK14(3), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNF(4), TNFRSF1A(5), TRADD(2), TRAF2(5) 13892378 103 78 100 34 66 4 11 4 18 0 0.648 1.000 1.000 368 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(14), CR2(17), FCGR2B(2), HLA-DRA(4), HLA-DRB1(1), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19) 8820248 90 77 89 30 38 5 23 10 14 0 0.597 1.000 1.000 369 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(65), CDC25A(5), CDC25B(2), CDC25C(2), CHEK1(3), MYT1(10), WEE1(10), YWHAH(2) 8041527 99 77 96 22 43 6 14 13 22 1 0.405 1.000 1.000 370 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(12), ARHGEF1(8), GNA12(3), GNA13(12), GNAQ(3), GNB1(7), MYL2(4), MYLK(15), PLCB1(17), PPP1R12B(10), PRKCA(3), ROCK1(8) 12072772 102 77 95 31 57 3 19 15 8 0 0.701 1.000 1.000 371 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 13 APAF1(7), ATM(65), BAX(2), CCND1(4), CCNE1(3), CDK2(1), CDK4(6), E2F1(3), GADD45A(1), MDM2(6), PCNA(4) 8885815 102 77 98 22 49 5 14 11 22 1 0.300 1.000 1.000 372 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UGDH(5), UGP2(9), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2A1(5), UGT2A3(5), UGT2B10(3), UGT2B11(4), UGT2B15(6), UGT2B17(6), UGT2B28(5), UGT2B4(4), UGT2B7(2), XYLB(8) 15913885 102 76 98 29 49 7 13 16 17 0 0.484 1.000 1.000 373 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), P4HB(6), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(6) 14352855 85 76 84 40 40 6 22 6 11 0 0.999 1.000 1.000 374 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(10), BCAR1(6), CSK(7), CTNNA1(6), CTNNA2(22), CTNNB1(15), PTK2(15), PXN(3), SRC(5), VCL(4) 11096019 100 75 96 23 47 8 24 11 10 0 0.112 1.000 1.000 375 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(6), F2(3), F2R(2), F5(24), F7(8), FGA(17), FGB(5), FGG(7), PROC(2), PROS1(14), SERPINC1(7) 9579714 95 75 93 22 54 4 18 9 10 0 0.208 1.000 1.000 376 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), ADC(6), AGMAT(1), ALDH18A1(3), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), AOC2(5), AOC3(6), ARG1(2), ARG2(3), ASL(7), ASS1(2), CPS1(13), GATM(3), MAOA(4), MAOB(2), NAGS(1), ODC1(4), OTC(2), SAT2(3), SMS(1), SRM(3) 17041271 98 75 95 28 48 3 18 14 15 0 0.202 1.000 1.000 377 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2B1(9), MAN2B2(7), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5) 11757472 85 75 84 28 44 1 20 10 10 0 0.492 1.000 1.000 378 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(4), ADCY1(6), CAP1(12), CCNB1(5), CDC25C(2), GNAI1(4), GNAS(12), GNB1(7), MAPK3(8), MYT1(10), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RPS6KA1(5), SRC(5) 11706600 102 75 101 29 47 6 27 12 10 0 0.317 1.000 1.000 379 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(6), AP2M1(2), BAD(3), BTK(5), EEA1(13), GRASP(3), GSK3A(2), GSK3B(5), LYN(5), PDPK1(2), PFKL(2), PFKM(5), PFKP(4), PLCG1(12), PRKCE(5), PRKCZ(4), RAB5A(2), RAC1(4), RPS6KB1(4), VAV2(8) 14514204 99 75 99 32 57 5 10 13 13 1 0.471 1.000 1.000 380 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(6), APEX1(1), CREBBP(50), DFFA(6), DFFB(1), GZMA(4), GZMB(2), HMGB2(6), NME1(1), PRF1(7), SET(3) 6128157 87 75 84 24 28 2 20 9 27 1 0.481 1.000 1.000 381 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(6), AKT1(3), BAD(3), BAX(2), BCL2L1(4), CSF2RB(5), IGF1(2), IGF1R(11), IL3RA(6), KIT(9), KITLG(5), PIK3R1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), YWHAH(2) 11485732 87 74 86 26 26 5 22 9 25 0 0.391 1.000 1.000 382 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(5), CSNK1D(3), DRD1(2), DRD2(5), GRM1(22), PLCB1(17), PPP1CA(8), PPP1R1B(5), PPP2CA(2), PPP3CA(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 9327568 101 74 101 26 50 3 24 12 12 0 0.128 1.000 1.000 383 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(6), ALDOB(3), ALDOC(2), DERA(3), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKL(2), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1), TKTL1(7), TKTL2(5) 14132949 90 74 90 50 37 4 27 12 10 0 0.994 1.000 1.000 384 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(11), ELK1(1), FOS(4), GRB2(3), JUN(4), KLK2(1), MAP2K1(3), MAPK3(8), MAPK8(5), NGFR(4), PIK3R1(7), PLCG1(12), RAF1(4), SHC1(8), SOS1(23) 9588076 98 74 95 25 51 4 16 13 14 0 0.286 1.000 1.000 385 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ALPI(5), ALPL(4), ALPP(3), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(4), CYP3A7(9), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), PON1(6), PON2(2), PON3(3) 10449981 96 73 92 40 42 4 28 7 15 0 0.841 1.000 1.000 386 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), DDOST(1), DPAGT1(6), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(9), MGAT1(9), MGAT2(2), MGAT3(4), MGAT4A(6), MGAT4B(5), MGAT5(7), RPN1(3), RPN2(5), ST6GAL1(4) 11514005 89 73 89 34 42 4 19 15 9 0 0.747 1.000 1.000 387 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(5), CS(3), DLD(7), DLST(1), FH(7), IDH1(9), IDH2(2), IDH3A(3), IDH3B(6), IDH3G(1), MDH1(3), PC(10), PCK1(9), SDHA(9), SDHB(2), SUCLA2(2), SUCLG1(2), SUCLG2(3) 12013419 88 72 87 29 50 2 20 6 10 0 0.529 1.000 1.000 388 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(6), GPLD1(5), PGAP1(5), PIGA(3), PIGB(5), PIGC(4), PIGF(4), PIGG(7), PIGK(4), PIGL(2), PIGM(2), PIGN(1), PIGO(11), PIGQ(5), PIGS(9), PIGT(2), PIGU(5), PIGV(6), PIGW(5), PIGZ(3) 13765901 94 72 93 33 46 2 26 5 15 0 0.393 1.000 1.000 389 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(2), AGPAT3(3), AGPAT4(3), AGPAT6(4), AGPS(5), CHPT1(6), ENPP2(7), ENPP6(3), PAFAH1B1(2), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(4), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4), PLD1(9), PLD2(3), PPAP2A(5), PPAP2B(3), PPAP2C(1) 13463168 89 72 89 45 47 2 11 11 18 0 0.994 1.000 1.000 390 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(3), ATG7(4), BECN1(2), GABARAP(3), IFNA1(1), IFNA10(2), IFNA14(1), IFNA16(3), IFNA2(1), IFNA21(1), IFNA4(3), IFNA5(3), IFNA8(1), IFNG(2), PIK3C3(11), PIK3R4(11), PRKAA1(9), PRKAA2(7), ULK1(9), ULK2(9), ULK3(1) 12161636 90 72 89 26 54 7 17 7 5 0 0.478 1.000 1.000 391 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), ESRRA(2), HDAC5(6), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), PPARA(1), PPP3CA(7), PPP3CB(7), PPP3CC(4), SLC2A4(4), SYT1(6), YWHAH(2) 11670640 93 72 93 43 49 9 9 12 14 0 0.970 1.000 1.000 392 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(5), ANXA2(2), ANXA3(3), ANXA4(1), ANXA5(4), ANXA6(6), CYP11A1(1), EDN1(2), EDNRA(4), EDNRB(8), HPGD(1), HSD11B2(3), PLA2G4A(1), PRL(3), PTGDR(3), PTGDS(1), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(6), S100A6(2), TBXAS1(3) 12021185 84 72 84 37 35 5 32 3 9 0 0.892 1.000 1.000 393 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(3), AGTR1(3), AGTR2(4), CMA1(1), COL4A1(14), COL4A2(11), COL4A3(13), COL4A4(16), COL4A5(5), COL4A6(6), REN(3) 14486384 84 71 83 34 34 6 27 5 12 0 0.996 1.000 1.000 394 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(12), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), CYP2C19(7), CYP2C9(3), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1) 18013869 85 71 84 28 37 2 26 5 15 0 0.700 1.000 1.000 395 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(1), ASRGL1(3), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(3), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(4), GLS2(4), GLUD1(6), GLUD2(10), GLUL(3), HAL(7) 12378382 87 71 86 27 39 6 20 9 13 0 0.598 1.000 1.000 396 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(3), BAD(3), GRB2(3), IGF1R(11), IRS1(9), MAP2K1(3), MAPK3(8), PIK3R1(7), RAF1(4), SHC1(8), SOS1(23), YWHAH(2) 9562296 84 71 83 27 40 3 16 12 13 0 0.701 1.000 1.000 397 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(2), ACP5(8), ACP6(2), ACPP(11), ACPT(4), ENPP1(7), ENPP3(6), FLAD1(9), LHPP(2), MTMR1(8), MTMR2(6), MTMR6(8), RFK(1), TYR(12) 8779717 88 69 86 28 45 4 19 8 12 0 0.756 1.000 1.000 398 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGAM(13), ITGB1(3), ITGB2(7), SELE(7), SELP(7) 9229964 82 69 81 31 46 3 17 6 10 0 0.816 1.000 1.000 399 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(8), DPYD(14), DPYS(13), ENPP1(7), ENPP3(6), PANK1(3), PANK2(5), PANK3(5), PANK4(7), PPCS(9), UPB1(4) 8119133 85 69 81 35 38 5 16 16 10 0 0.963 1.000 1.000 400 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(7), BIRC2(3), BIRC3(3), CASP10(1), CASP3(3), CASP7(5), CASP8(14), CASP9(6), DFFA(6), DFFB(1), GZMB(2), PRF1(7), SCAP(9), SREBF1(6), SREBF2(8) 10509336 81 69 81 28 42 4 16 6 13 0 0.723 1.000 1.000 401 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(3), AKT2(5), AKT3(8), BPNT1(2), GRB2(3), ILK(3), MAPK3(8), PDK1(2), PIK3CD(7), PTK2B(6), RBL2(9), SHC1(8), SOS1(23) 10126383 87 69 86 21 49 3 18 9 8 0 0.169 1.000 1.000 402 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(3), HSPA1A(3), IFNG(2), IFNGR1(1), IFNGR2(6), IKBKB(11), JAK2(8), LIN7A(3), NFKB1(3), NFKBIA(6), RELA(6), TNF(4), TNFRSF1A(5), TNFRSF1B(6), USH1C(10), WT1(4) 8923474 81 69 79 23 49 3 12 3 14 0 0.395 1.000 1.000 403 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(6), AGT(3), AGTR2(4), EDN1(2), EDNRA(4), EDNRB(8), EGF(17), EGFR(7), FOS(4), JUN(4), MYC(2), NFKB1(3), PLCG1(12), PRKCA(3), RELA(6) 11715209 85 68 83 37 44 8 20 4 9 0 0.935 1.000 1.000 404 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(10), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(5), HS2ST1(4), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), HS6ST2(2), HS6ST3(1), NDST1(2), NDST2(2), NDST3(7), NDST4(13) 11958635 77 68 77 36 40 5 15 8 9 0 0.920 1.000 1.000 405 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(1), IL22RA1(4), IL22RA2(3), JAK1(9), JAK2(8), JAK3(12), SOCS3(1), STAT1(13), STAT3(6), STAT5A(1), STAT5B(5), TYK2(9) 10651332 81 68 80 32 31 4 14 7 25 0 0.844 1.000 1.000 406 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(10), CALM1(2), CALM2(2), CAPN2(2), CAPNS2(1), HDAC1(4), HDAC2(3), MEF2D(3), NFATC1(14), NFATC2(13), PPP3CA(7), PPP3CB(7), PPP3CC(4), PRKCA(3), SYT1(6) 11306315 81 68 81 32 34 10 15 9 13 0 0.931 1.000 1.000 407 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(7), IFNG(2), IKBKB(11), IL2(1), JUN(4), MAP3K1(10), MAP3K5(14), MAP4K5(4), MAPK14(3), MAPK8(5), NFKB1(3), NFKBIA(6), RELA(6), TNFRSF9(2), TNFSF9(2), TRAF2(5) 11162507 86 67 84 28 53 2 12 3 16 0 0.767 1.000 1.000 408 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(4), ADSL(4), ADSS(4), AGXT(2), AGXT2(2), ASL(7), ASNS(1), ASPA(2), CAD(16), CRAT(10), DARS(3), DDO(1), GAD1(8), GAD2(6), GOT1(2), GPT(2), GPT2(1), NARS(4), PC(10) 15154734 93 67 92 40 53 3 18 10 9 0 0.907 1.000 1.000 409 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8), MASP1(12), MASP2(5), MBL2(1) 12378608 87 67 87 29 34 5 28 10 10 0 0.718 1.000 1.000 410 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(3), GCLC(6), GCLM(2), GGT1(5), GPX1(2), GPX2(1), GPX3(4), GPX5(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA4(2), GSTM1(2), GSTM2(4), GSTM3(4), GSTM5(5), GSTO2(2), GSTP1(2), GSTT1(2), GSTZ1(2), IDH1(9), IDH2(2), MGST1(1), MGST2(1), MGST3(1), PGD(5) 10468473 90 67 90 36 45 3 22 5 15 0 0.710 1.000 1.000 411 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(9), DYRK1B(5), GLI2(16), GLI3(19), GSK3B(5), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), SHH(6), SMO(8), SUFU(2) 9663705 92 67 91 24 33 4 34 5 16 0 0.210 1.000 1.000 412 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), LTA(1), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), RIPK1(7), TANK(3), TNFAIP3(7), TNFRSF1B(6), TRAF2(5), TRAF3(2) 13016567 87 67 87 22 53 4 12 3 15 0 0.261 1.000 1.000 413 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(28), ACACB(21), FASN(12), MCAT(2), OLAH(4), OXSM(8) 9087372 75 66 73 20 42 6 10 10 7 0 0.161 1.000 1.000 414 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLR3A(11), POLR3B(6), POLR3GL(1), POLR3H(2) 13668577 90 66 89 40 55 4 13 8 10 0 0.978 1.000 1.000 415 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(11), ACE2(5), AGT(3), AGTR1(3), AGTR2(4), ANPEP(6), CMA1(1), CPA3(7), CTSA(3), CTSG(4), ENPEP(9), LNPEP(7), MAS1(2), MME(13), NLN(2), REN(3), THOP1(6) 12312028 89 66 87 34 41 3 20 12 13 0 0.752 1.000 1.000 416 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(6), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(7) 8727356 78 65 73 24 40 2 18 9 9 0 0.379 1.000 1.000 417 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(5), FOS(4), GRB2(3), IL3RA(6), JAK2(8), MAP2K1(3), MAPK3(8), PTPN6(2), RAF1(4), SHC1(8), SOS1(23), STAT5A(1), STAT5B(5) 10072656 80 65 79 27 40 3 11 9 17 0 0.724 1.000 1.000 418 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(3), BCAR1(6), CDKN1B(6), GRB2(3), ILK(3), ITGB1(3), MAPK3(8), PDK2(2), PDPK1(2), PIK3R1(7), PTK2(15), SHC1(8), SOS1(23) 9457637 89 65 88 20 48 5 17 6 13 0 0.281 1.000 1.000 419 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(6), CHAT(5), COMT(3), DBH(4), DDC(8), GAD1(8), GAD2(6), HDC(6), MAOA(4), PAH(11), SLC18A3(5), TH(2), TPH1(3) 8271059 73 64 73 39 25 3 25 8 12 0 0.982 1.000 1.000 420 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C8B(3), C9(8), MASP1(12) 12095257 84 64 84 28 34 5 27 9 9 0 0.717 1.000 1.000 421 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 19 CCNA1(4), CCNB1(5), CCND1(4), CCND2(1), CCND3(8), CCNE1(3), CCNH(4), CDC25A(5), CDK2(1), CDK4(6), CDK6(5), CDK7(6), CDKN1B(6), CDKN2B(3), CDKN2C(2), CDKN2D(1), E2F1(3), RBL1(9), TFDP1(2) 7746790 78 63 75 20 42 2 16 6 12 0 0.307 1.000 1.000 422 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(17), EGFR(7), MAP2K1(3), MAP3K1(10), MAPK14(3), NCOR2(19), RARA(6), THRA(2), THRB(1) 9417172 68 63 68 20 29 2 20 4 13 0 0.502 1.000 1.000 423 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(3), EIF2B5(11), EIF2S1(5), EIF2S2(1), EIF2S3(6), EIF4E(2), EIF4EBP1(1), GSK3B(5), IGF1(2), IGF1R(11), INPPL1(11), PDK2(2), PDPK1(2), PIK3R1(7), PPP2CA(2), RPS6(5), RPS6KB1(4) 9688265 80 63 80 22 41 1 21 2 14 1 0.366 1.000 1.000 424 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(2), FUCA2(6), GLB1(5), HEXA(3), HEXB(2), LCT(16), MAN2C1(8), MANBA(5), NEU1(2), NEU2(3), NEU3(7), NEU4(5) 9523377 69 63 69 21 35 1 16 9 8 0 0.472 1.000 1.000 425 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(3), GRB2(3), MAPK3(8), MAPK7(3), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), NTRK1(7), PIK3R1(7), PLCG1(12), RPS6KA1(5), SHC1(8) 9442036 74 62 74 27 37 4 20 2 11 0 0.625 1.000 1.000 426 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(6), CHPT1(6), HEMK1(1), LCMT1(2), LCMT2(12), METTL2B(3), METTL6(5), PCYT1A(2), PCYT1B(2), PRMT2(3), PRMT3(2), PRMT5(4), PRMT6(1), PRMT7(10), PRMT8(7), WBSCR22(7) 8144103 73 62 69 22 42 3 12 8 8 0 0.458 1.000 1.000 427 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(1), CA1(3), CA12(2), CA14(1), CA2(2), CA3(1), CA4(2), CA5A(4), CA5B(3), CA6(3), CA7(1), CA8(3), CA9(3), CPS1(13), CTH(5), GLS(4), GLS2(4), GLUD1(6), GLUL(3), HAL(7) 11083784 74 62 73 21 35 4 14 9 12 0 0.426 1.000 1.000 428 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(3), HLA-A(7), ITGB1(3), KLRC2(3), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(3), MAPK3(8), PAK1(4), PIK3R1(7), PTK2B(6), PTPN6(2), RAC1(4), SYK(8), VAV1(8) 9542821 72 62 71 24 29 2 14 8 19 0 0.777 1.000 1.000 429 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 18 AKT1(3), CCND1(4), CCNE1(3), CDK2(1), CDK4(6), CDK6(5), CDKN1B(6), E2F1(3), MAPK3(8), NFKB1(3), NFKBIA(6), PAK1(4), PIK3R1(7), RAC1(4), RAF1(4), RELA(6), TFDP1(2) 8999041 75 62 73 24 42 3 10 6 14 0 0.643 1.000 1.000 430 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(4), GCK(1), GFPT1(5), GNE(8), GNPDA1(3), GNPDA2(2), HEXA(3), HEXB(2), HK1(15), HK2(11), HK3(8), PGM3(2), RENBP(4), UAP1(5) 9831287 75 61 74 34 37 6 17 5 10 0 0.966 1.000 1.000 431 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(3), AKT1(3), ANXA1(5), CALM1(2), CALM2(2), GNAS(12), GNB1(7), NFKB1(3), NOS3(11), NPPA(2), NR3C1(6), PIK3R1(7), RELA(6), SYT1(6) 9061589 75 61 73 23 47 5 10 3 10 0 0.717 1.000 1.000 432 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(13), DNMT3B(7), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), MTFMT(2), MTR(7), SRM(3), TAT(5) 11994594 71 61 71 28 35 4 16 8 8 0 0.817 1.000 1.000 433 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(5), B3GNT3(1), B3GNT4(3), B3GNT5(8), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), FUT1(3), FUT2(6), FUT3(3), FUT4(3), FUT5(5), FUT6(2), FUT7(3), FUT9(3), GCNT2(10), ST3GAL6(6), ST8SIA1(3) 9371057 79 61 77 29 39 1 18 12 9 0 0.599 1.000 1.000 434 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), BST1(4), CD38(1), ENPP1(7), ENPP3(6), NADK(4), NADSYN1(6), NMNAT2(1), NMNAT3(1), NNMT(3), NNT(8), NT5C(1), NT5C1A(6), NT5C1B(4), NT5C2(1), NT5E(6), NUDT12(3), QPRT(4) 12532409 74 61 73 29 42 5 11 4 12 0 0.894 1.000 1.000 435 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(28), CPT1A(7), LEP(1), LEPR(8), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKAG1(3) 8483238 67 61 67 21 34 4 9 10 10 0 0.701 1.000 1.000 436 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), G6PD(3), GPI(4), H6PD(12), PFKM(5), PFKP(4), PGD(5), PGM1(3), PGM3(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(3), TALDO1(4), TKT(1) 11903459 73 61 73 41 30 3 23 10 7 0 0.991 1.000 1.000 437 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 12 AKT1(3), AKT2(5), AKT3(8), ELK1(1), GRB2(3), MAP2K1(3), MAP2K2(5), NGFR(4), NTRK1(7), PIK3CD(7), SHC1(8), SOS1(23) 7627699 77 61 76 21 43 1 16 11 6 0 0.275 1.000 1.000 438 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(3), GOSR1(2), GOSR2(1), SNAP23(3), SNAP25(4), SNAP29(4), STX10(3), STX11(2), STX12(3), STX16(2), STX18(2), STX19(2), STX2(5), STX3(5), STX4(3), STX5(2), STX6(2), STX7(2), STX8(2), TSNARE1(4), USE1(4), VAMP1(1), VAMP2(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(3), VAMP8(2), VTI1A(1), VTI1B(6), YKT6(1) 9641982 78 60 78 28 46 3 16 7 6 0 0.731 1.000 1.000 439 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(9), E2F1(3), MDM2(6), MYC(2), PIK3R1(7), POLR1A(18), POLR1B(5), POLR1C(5), POLR1D(4), RAC1(4), TBX2(7) 8712130 70 59 69 26 40 3 12 4 11 0 0.828 1.000 1.000 440 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(7), ARHGAP5(12), ARHGDIB(1), CASP1(9), CASP10(1), CASP3(3), CASP8(14), CASP9(6), CYCS(1), GZMB(2), JUN(4), PRF1(7) 7525762 67 59 65 22 30 4 12 10 11 0 0.844 1.000 1.000 441 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(7), CYP51A1(4), DHCR24(3), DHCR7(3), EBP(1), FDPS(6), GGCX(7), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(4), LSS(7), MVD(4), NSDHL(3), PMVK(1), SQLE(4), TM7SF2(1), VKORC1(4) 11122542 72 59 72 19 38 3 15 8 8 0 0.178 1.000 1.000 442 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), HGSNAT(4), HPSE(4), HPSE2(4), HYAL2(4), IDS(4), IDUA(1), LCT(16), NAGLU(5), SPAM1(2) 11836355 70 59 70 23 40 3 11 11 5 0 0.453 1.000 1.000 443 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMC2(9), PSMC3(5), PSMD1(7), PSMD11(4), PSMD12(4), PSMD2(6), PSMD6(3) 9340626 72 59 71 23 44 1 13 8 6 0 0.702 1.000 1.000 444 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(6), CD3E(2), CD3G(2), CXCR3(3), ETV5(4), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), JAK2(8), JUN(4), MAP2K6(1), MAPK14(3), MAPK8(5), STAT4(9), TYK2(9) 10798436 74 59 72 38 36 2 15 6 15 0 0.997 1.000 1.000 445 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(4), IL6R(4), JAK1(9), JAK2(8), JAK3(12), PIAS3(6), PTPRU(7), REG1A(8), SRC(5), STAT3(6) 8831183 70 59 70 18 33 2 21 4 10 0 0.155 1.000 1.000 446 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(5), F13A1(8), F2(3), F2R(2), FGA(17), FGB(5), FGG(7), PLAT(6), PLAU(2), PLG(4), SERPINB2(3), SERPINE1(6) 7811469 68 58 67 19 31 2 16 10 9 0 0.504 1.000 1.000 447 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(3), ARG1(2), ARG2(3), ASL(7), CKB(5), CKM(5), CKMT1B(1), CKMT2(9), CPS1(13), GATM(3), GLUD1(6), NAGS(1), OAT(1), ODC1(4), OTC(2), PYCR1(3), SMS(1) 10130109 72 58 70 24 40 2 12 9 9 0 0.590 1.000 1.000 448 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), NCK1(2), NCKAP1(12), NTRK1(7), PIR(2), RAC1(4), WASF1(5), WASF2(7), WASF3(5), WASL(2) 8905019 70 57 68 23 37 3 14 5 11 0 0.802 1.000 1.000 449 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 18 AKT1(3), BAD(3), BCL2L1(4), CASP9(6), CDC42(4), CHUK(7), ELK1(1), H2AFX(3), MAP2K1(3), MAPK3(8), NFKB1(3), PIK3R1(7), RAC1(4), RAF1(4), RALA(2), RALBP1(2), RALGDS(4), RELA(6) 9242833 74 57 73 27 35 3 11 7 18 0 0.904 1.000 1.000 450 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(3), GRB2(3), KLK2(1), NTRK1(7), PIK3R1(7), PLCG1(12), PRKCA(3), SHC1(8), SOS1(23) 7565024 67 57 66 24 37 1 15 7 7 0 0.769 1.000 1.000 451 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(4), ARFGEF2(18), CLTA(3), CLTB(1), COPA(12), GBF1(16), GPLD1(5), KDELR2(4), KDELR3(1) 9493504 68 56 68 22 44 6 7 1 10 0 0.502 1.000 1.000 452 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 CUZD1(3), FOS(4), JUN(4), MAP2K1(3), MAPK3(8), MYC(2), NFKB1(3), NFKBIA(6), PLCB1(17), PRKCA(3), RAF1(4), RELA(6), TNF(4) 8803696 67 56 65 25 36 3 12 7 9 0 0.793 1.000 1.000 453 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(6), GNAS(12), GNB1(7), PPP2CA(2), PRKAA1(9), PRKAA2(7), PRKAB1(3), PRKAB2(1), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 8942055 72 56 71 16 33 6 17 8 8 0 0.174 1.000 1.000 454 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(3), MAP2K1(3), MAP2K2(5), MAP2K3(6), MAP2K6(1), MAP3K1(10), MAPK14(3), MAPK3(8), NFKB1(3), PIK3R1(7), RELA(6), SP1(10) 8961894 65 56 65 31 30 3 13 4 15 0 0.992 1.000 1.000 455 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(3), EGFR(7), IGF1R(11), MYC(2), POLR2A(13), PPP2CA(2), PRKCA(3), TEP1(14), TERF1(5), TERT(4), TNKS(6), XRCC5(1) 14863341 71 56 71 40 34 2 23 5 7 0 0.995 1.000 1.000 456 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD2(2), CD33(6), CD5(3), CD7(3), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL5(1), ITGAX(3), TLR2(3), TLR4(6), TLR7(9), TLR9(12) 10838493 63 55 63 28 30 5 14 6 8 0 0.813 1.000 1.000 457 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL5(1), JUNB(5), MAF(3), MAP2K3(6), MAPK14(3), NFATC1(14), NFATC2(13), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7020066 75 55 75 28 27 5 24 7 12 0 0.675 1.000 1.000 458 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(6), B4GALNT1(2), GLB1(5), HEXA(3), HEXB(2), LCT(16), SLC33A1(3), ST3GAL1(1), ST3GAL2(3), ST3GAL5(5), ST6GALNAC3(5), ST6GALNAC4(2), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(3), ST8SIA5(2) 9619087 64 55 64 30 33 3 13 11 4 0 0.906 1.000 1.000 459 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TKTL1(7), TKTL2(5), TPI1(1) 11714053 63 55 63 31 29 1 20 9 4 0 0.941 1.000 1.000 460 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(7), BAK1(2), BAX(2), BCL2L1(4), BID(2), BIK(1), BIRC2(3), BIRC3(3), CASP3(3), CASP6(1), CASP7(5), CASP8(14), CASP9(6), CYCS(1), DFFA(6), DFFB(1), DIABLO(3) 7837497 64 55 63 24 34 4 13 1 12 0 0.938 1.000 1.000 461 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(4), CD3E(2), CD3G(2), CD8A(2), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3) 6263281 65 55 65 25 31 3 16 5 10 0 0.605 1.000 1.000 462 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(4), CD3E(2), CD3G(2), CD4(3), ICAM1(7), ITGAL(17), ITGB2(7), PTPRC(19), THY1(3) 6570969 66 55 66 26 32 2 16 6 10 0 0.647 1.000 1.000 463 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1R(3), C1S(8), C2(2), C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8) 10164025 69 54 69 25 29 5 22 5 8 0 0.837 1.000 1.000 464 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(7), ITGA4(19), ITGAL(17), ITGB1(3), ITGB2(7), SELE(7) 7028740 62 54 61 21 34 1 13 5 9 0 0.677 1.000 1.000 465 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(1), CBS(2), CTH(5), DNMT1(11), DNMT3A(13), DNMT3B(7), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), MTR(7) 10102031 61 54 61 23 30 3 15 7 6 0 0.726 1.000 1.000 466 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(2), CCR1(1), CCR3(3), CCR4(3), CCR5(6), CCR7(3), CD28(4), CD4(3), CXCR3(3), CXCR4(4), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL4R(6), IL5(1), TGFB1(3), TGFB3(1) 11623419 69 54 69 34 28 2 16 13 10 0 0.943 1.000 1.000 467 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(5), DAB1(5), FYN(7), LRP8(7), RELN(36), VLDLR(6) 8197876 69 54 69 20 33 4 18 9 5 0 0.601 1.000 1.000 468 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(7), DUSP1(3), IKBKAP(10), IKBKB(11), MAP3K1(10), NFKB1(3), NFKBIA(6), RELA(6), TNFAIP3(7), TRAF3(2), TRAF6(1) 10519839 66 53 66 18 41 3 7 1 14 0 0.469 1.000 1.000 469 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(5), CLOCK(8), CRY1(3), CRY2(4), CSNK1D(3), CSNK1E(3), NPAS2(8), NR1D1(3), PER1(6), PER2(6), PER3(12) 9864281 61 53 61 26 30 1 16 4 10 0 0.951 1.000 1.000 470 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(2), CCL2(1), CCR5(6), CXCL12(6), CXCR4(4), FOS(4), GNAQ(3), JUN(4), MAPK14(3), MAPK8(5), PLCG1(12), PRKCA(3), PTK2B(6), SYT1(6) 8024865 67 52 65 24 29 5 11 11 11 0 0.699 1.000 1.000 471 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(13), EGF(17), EGFR(7), HGS(11), RAB5A(2), TF(4), TFRC(9) 7521093 63 52 62 22 35 4 11 6 7 0 0.887 1.000 1.000 472 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(5), AFMID(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6) 7826098 59 52 58 19 28 3 19 2 7 0 0.498 1.000 1.000 473 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(3), ATIC(2), FTCD(4), GART(7), MTFMT(2), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3) 11036760 64 52 64 26 30 4 14 6 10 0 0.875 1.000 1.000 474 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(4), ITPKA(4), PDE1A(8), PDE1B(4), PLCB1(17), PLCB2(6), PRL(3), TRH(6) 6429814 57 52 56 19 27 2 16 8 4 0 0.619 1.000 1.000 475 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(3), CAT(9), GH1(3), GHR(6), IGF1(2), IGF1R(11), PIK3R1(7), SHC1(8), SOD1(4), SOD2(1), SOD3(1) 6210911 55 51 55 17 20 0 19 7 9 0 0.531 1.000 1.000 476 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(7), BRAF(9), CAMP(1), CREB3(5), CREB5(11), RAF1(4), SNX13(5), SRC(5), TERF2IP(4) 6451866 55 51 55 20 24 3 8 11 9 0 0.880 1.000 1.000 477 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(3), ACTR3(2), ARPC1A(4), ARPC1B(1), ARPC2(5), ARPC4(5), CDC42(4), PAK1(4), PDGFRA(16), PIK3R1(7), RAC1(4), WASL(2) 6548674 57 50 57 13 24 2 10 5 16 0 0.379 1.000 1.000 478 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(5), ACAT2(1), ACOT11(12), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ECHS1(1), EHHADH(6), ESCO1(3), ESCO2(3), FN3K(2), GCDH(6), HADHA(4), NAT6(1), PNPLA3(4), SH3GLB1(1), YOD1(1) 15167842 65 50 64 23 35 1 16 3 10 0 0.856 1.000 1.000 479 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(3), IL2RG(5), IL4R(6), IRS1(9), JAK1(9), JAK3(12), RPS6KB1(4), SHC1(8), STAT6(9) 8545155 68 50 68 26 31 1 17 9 9 1 0.760 1.000 1.000 480 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(3), ATIC(2), ATP6V0C(3), GART(7), MTHFD1(7), MTHFD1L(9), MTHFD2(6), MTHFR(4), MTHFS(2), MTR(7), SHMT1(3), SHMT2(2), TYMS(3) 10448764 61 50 61 25 32 3 14 4 8 0 0.859 1.000 1.000 481 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(2), GUSB(3), RPE(1), UCHL1(3), UCHL3(3), UGDH(5), UGT1A1(14), UGT1A10(5), UGT1A3(5), UGT1A4(1), UGT1A6(3), UGT1A7(1), UGT1A9(3), UGT2B15(6), UGT2B4(4) 10241286 61 50 61 22 27 3 11 11 9 0 0.796 1.000 1.000 482 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(2), EPHB1(14), FYN(7), ITGA1(7), ITGB1(3), L1CAM(8), LYN(5), RAP1B(2), SELP(7) 9223404 59 49 59 18 26 3 17 6 7 0 0.563 1.000 1.000 483 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 ARNT(9), EPO(2), EPOR(5), GRIN1(9), HIF1A(6), JAK2(8), NFKB1(3), NFKBIA(6), RELA(6), SOD2(1) 7108240 55 49 54 14 34 3 7 3 8 0 0.441 1.000 1.000 484 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(5), ADH1A(5), ADH1B(3), ADH4(2), ADH5(1), ADH6(7), ADH7(4), ADHFE1(4), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1) 14554566 61 49 60 18 28 2 18 5 8 0 0.579 1.000 1.000 485 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(6), CD2(2), CD3E(2), CD3G(2), CD4(3), CXCR3(3), IFNG(2), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), JAK2(8), STAT4(9), TYK2(9) 8489089 58 49 58 28 22 3 15 6 12 0 0.975 1.000 1.000 486 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(9), JAK2(8), JAK3(12), PIAS1(3), PIAS3(6), PTPRU(7), REG1A(8), SOAT1(5) 7938106 59 49 59 19 26 2 18 3 10 0 0.516 1.000 1.000 487 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(2), CD3G(2), GZMB(2), HLA-A(7), ICAM1(7), ITGAL(17), ITGB2(7), PRF1(7) 5075094 54 48 53 22 20 0 16 7 11 0 0.651 1.000 1.000 488 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(15), KHK(1), LCT(16), MPI(7), PGM1(3), PYGL(4), PYGM(13), TPI1(1), TREH(5) 7756453 65 48 64 28 33 4 16 5 7 0 0.752 1.000 1.000 489 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(5), CS(3), GRHPR(2), HAO1(5), HAO2(8), HYI(2), MDH1(3), MTHFD1(7), MTHFD1L(9), MTHFD2(6) 7473972 54 48 53 19 25 2 19 2 6 0 0.644 1.000 1.000 490 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(5), B3GAT3(3), B4GALT7(1), CHPF(4), CHST11(2), CHST12(3), CHST14(3), CHST7(2), CHSY1(9), DSE(6), UST(4), XYLT1(6), XYLT2(6) 7961671 55 48 52 30 29 2 13 5 6 0 0.936 1.000 1.000 491 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(7), ITGAL(17), ITGAM(13), ITGB2(7), SELE(7) 5987153 53 48 52 23 29 1 14 3 6 0 0.772 1.000 1.000 492 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(2), ACP5(8), ACPP(11), ACPT(4), ENPP1(7), ENPP3(6), FLAD1(9), RFK(1), TYR(12) 5664987 62 48 60 22 30 3 15 4 10 0 0.808 1.000 1.000 493 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), BAD(3), CASP9(6), CHUK(7), GH1(3), GHR(6), NFKB1(3), NFKBIA(6), PDPK1(2), PIK3R1(7), PPP2CA(2), RELA(6), YWHAH(2) 6893126 56 47 56 14 28 4 10 2 12 0 0.454 1.000 1.000 494 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(6), ALDOB(3), ALDOC(2), FBP1(3), FBP2(2), GOT1(2), GPT(2), GPT2(1), MDH1(3), ME1(5), ME2(1), ME3(6), PGK1(2), PKLR(8), RPE(1), RPIA(3), TKT(1), TPI1(1) 10461276 52 47 52 26 25 1 16 7 3 0 0.941 1.000 1.000 495 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(8), GALNS(3), GLB1(5), GNS(2), GUSB(3), HEXA(3), HEXB(2), IDS(4), IDUA(1), LCT(16), NAGLU(5) 8306878 52 47 52 15 31 3 8 7 3 0 0.304 1.000 1.000 496 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(10), ACO1(4), ACO2(5), ACSS1(7), ACSS2(3), FH(7), IDH1(9), IDH2(2), MDH1(3), SUCLA2(2) 7760514 52 47 52 31 26 3 6 9 8 0 0.989 1.000 1.000 497 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), AOC2(5), AOC3(6), CES1(4), DDHD1(11), ESCO1(3), ESCO2(3), LIPA(3), NAT6(1), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(5), SH3GLB1(1) 14716988 53 47 53 13 29 4 9 7 4 0 0.371 1.000 1.000 498 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(16), ABCB11(4), ABCB4(11), ABCC1(10), ABCC3(16), GSTP1(2) 8339112 59 47 58 20 35 4 10 5 5 0 0.332 1.000 1.000 499 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(9), JAK2(8), JAK3(12), MAPK3(8), STAT3(6), TYK2(9) 6769111 52 47 52 24 20 4 12 3 13 0 0.937 1.000 1.000 500 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(1), JAK1(9), PTPRU(7), REG1A(8), STAT1(13), STAT2(4), TYK2(9) 7270570 53 46 52 21 17 3 17 4 11 1 0.681 1.000 1.000 501 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(4), CD86(6), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(6), IL12A(1), IL12B(3), IL12RB1(2), IL12RB2(6), IL18R1(4), IL2(1), IL2RA(1), IL4R(6) 7382887 48 46 48 20 19 2 13 8 6 0 0.882 1.000 1.000 502 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(16), C5(9), C6(9), C7(4), C8A(7), C9(8) 7318348 53 45 53 19 24 5 16 4 4 0 0.851 1.000 1.000 503 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(3), FOS(4), JUN(4), MAPK3(8), OPRK1(4), POLR2A(13), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5) 7475395 58 45 56 21 30 3 13 3 9 0 0.678 1.000 1.000 504 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(1), EHHADH(6), HADH(5), HADHA(4), HSD17B10(1), HSD17B4(5), NTAN1(2), SIRT1(9), SIRT2(2), SIRT5(3), SIRT7(4), VNN2(4) 6900744 48 45 46 15 32 3 3 3 7 0 0.753 1.000 1.000 505 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(3), FH(7), IDH2(2), MDH1(3), OGDH(21), SDHA(9), SUCLA2(2) 5497154 52 45 49 16 25 3 11 7 6 0 0.451 1.000 1.000 506 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(6), CTSD(6), ESR1(5), GREB1(17), HSPB1(1), HSPB2(4), MTA1(5), MTA3(1), PDZK1(2), TUBA8(2) 6210655 49 45 48 16 15 2 23 4 5 0 0.408 1.000 1.000 507 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(7), ENPP3(6), NADSYN1(6), NMNAT2(1), NNMT(3), NNT(8), NT5C(1), NT5E(6), QPRT(4) 8467349 51 45 50 19 30 3 7 4 7 0 0.797 1.000 1.000 508 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(7), DLL1(9), FURIN(9), NOTCH1(17), PSEN1(8) 5199560 50 45 48 16 22 3 15 1 7 2 0.461 1.000 1.000 509 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(14), ANKRD1(1), CYR61(6), DUSP14(4), EIF4E(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(6), IL1A(1), IL1R1(1), JUND(2), MYOG(2), NR4A3(5), WDR1(3) 6208349 51 44 48 16 32 3 6 3 7 0 0.618 1.000 1.000 510 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(6), ADRB2(3), GNAS(12), PLCE1(11), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), RAP2B(1) 8621275 55 44 55 20 23 2 15 6 9 0 0.774 1.000 1.000 511 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(4), CD3E(2), CD3G(2), IFNG(2), IL2(1), IL2RA(1), TGFB1(3), TGFB3(1), TGFBR1(7), TGFBR2(8), TGFBR3(10), TOB1(5), TOB2(2) 6161601 48 44 48 21 23 3 9 2 10 1 0.926 1.000 1.000 512 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2A(2), UBE2B(2), UBE2C(5), UBE2D1(2), UBE2D2(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2H(3), UBE2I(1), UBE2J1(5), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2N(4), UBE2S(2), UBE3A(10) 6125902 53 44 51 17 30 5 5 8 5 0 0.730 1.000 1.000 513 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(9), ASPH(3), COPS5(1), EDN1(2), EPO(2), HIF1A(6), JUN(4), NOS3(11), P4HB(6), VHL(2) 6954471 46 43 44 22 29 2 3 5 7 0 0.984 1.000 1.000 514 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7), ECHS1(1), EHHADH(6), HADHA(4), SDS(2) 7052603 48 43 47 20 24 2 8 5 9 0 0.806 1.000 1.000 515 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(6), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(2), CPT1A(7), CPT2(5), EHHADH(6), HADHA(4), SCP2(4), SLC25A20(3) 9805244 47 43 47 16 25 1 10 6 5 0 0.727 1.000 1.000 516 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(5), GALNT10(3), GALNT2(8), GALNT3(5), GALNT6(4), GALNT7(6), GALNT8(6), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), WBSCR17(9) 8417000 58 43 58 17 26 4 17 5 6 0 0.409 1.000 1.000 517 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PIK3R1(7), PLCB1(17), PLCG1(12), PRKCA(3), VAV1(8) 6218607 50 43 50 17 27 1 13 3 6 0 0.661 1.000 1.000 518 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(4), CD3E(2), CD3G(2), CD80(2), CD86(6), CTLA4(1), GRB2(3), HLA-DRA(4), HLA-DRB1(1), ICOS(2), IL2(1), ITK(6), LCK(2), PIK3R1(7), PTPN11(4) 6209393 47 42 47 12 20 1 13 7 6 0 0.387 1.000 1.000 519 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CARS2(7), CDO1(2), CTH(5), GOT1(2), LDHAL6A(2), LDHAL6B(2), LDHB(2), LDHC(4), MPST(1), SDS(2), SULT1B1(5), SULT1C2(4), SULT1C4(4) 7304186 47 42 46 17 23 5 10 2 7 0 0.757 1.000 1.000 520 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), IMPA2(4), ISYNA1(2), PGM1(3), PGM3(2), TGDS(3) 6757795 50 42 49 26 21 3 13 3 10 0 0.970 1.000 1.000 521 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(4), ACOX1(7), ACOX3(7), ELOVL2(2), ELOVL5(2), ELOVL6(1), FADS1(2), FADS2(2), FASN(12), HADHA(4), HSD17B12(3), SCD(2) 8249688 48 42 48 21 20 3 11 5 9 0 0.755 1.000 1.000 522 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(7), CASP3(3), CASP9(6), CYCS(1), DAXX(9), FAS(1), FASLG(1), HSPB1(1), HSPB2(4), IL1A(1), MAPKAPK2(1), MAPKAPK3(3), TNF(4) 6605523 46 42 46 26 21 5 12 1 7 0 0.994 1.000 1.000 523 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(4), HPRT1(1), IMPDH1(1), MTHFD2(6), NME2(3), OAZ1(4), POLD1(10), POLG(8), PRPS2(1), RRM1(4), SRM(3) 7223915 49 41 49 13 22 6 14 1 6 0 0.361 1.000 1.000 524 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(3), CDK2(1), CDKN1B(6), CUL1(19), E2F1(3), NEDD8(2), RBX1(1), SKP2(5), TFDP1(2), UBE2M(3) 3979020 45 41 40 13 28 0 8 3 6 0 0.397 1.000 1.000 525 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(4), CNR2(6), DNMT1(11), MTNR1A(4), MTNR1B(1), PTAFR(1), PTGDR(3), PTGER2(7), PTGER4(5), PTGFR(7), PTGIR(2) 6441056 51 41 51 25 22 4 17 2 6 0 0.695 1.000 1.000 526 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(2), CAMK1(5), CAMK1G(4), CAMK2A(5), CAMK2B(5), CAMK2D(4), CAMK2G(5), CAMK4(4), CAMKK1(3), CAMKK2(5), SYT1(6) 6669495 50 40 50 30 27 4 5 5 9 0 0.997 1.000 1.000 527 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(12), ALAS2(5), CPOX(5), FECH(3), PPOX(6), UROD(4), UROS(4) 4349525 44 40 44 19 20 3 4 7 10 0 0.946 1.000 1.000 528 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(4), CYP2A6(8), CYP2A7(10), NAT1(4), NAT2(1), XDH(11) 4683662 42 40 40 15 24 2 8 5 3 0 0.432 1.000 1.000 529 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(6), CAPN1(5), CAPNS2(1), CDK5(3), CDK5R1(5), CSNK1A1(6), CSNK1D(3), GSK3B(5), MAPT(10), PPP2CA(2) 5334023 46 40 46 29 23 1 10 3 9 0 0.999 1.000 1.000 530 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(2), GSS(7), NFKB1(3), NOX1(4), RELA(6), SOD1(4), TNF(4), XDH(11) 5747866 43 39 43 13 24 0 10 2 7 0 0.318 1.000 1.000 531 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(6), IFNB1(1), JAK1(9), STAT1(13), STAT2(4), TYK2(9) 6297014 45 39 44 16 16 3 9 3 13 1 0.625 1.000 1.000 532 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(11), AGT(3), AGTR1(3), AGTR2(4), BDKRB2(3), KNG1(5), NOS3(11), REN(3) 5659014 43 38 42 21 19 2 13 4 5 0 0.829 1.000 1.000 533 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(3), CASP7(5), DFFA(6), DFFB(1), GZMB(2), HMGB1(4), HMGB2(6), TOP2A(13), TOP2B(5) 5161152 45 38 45 13 28 2 6 5 4 0 0.818 1.000 1.000 534 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(7), ERBB4(11), NRG2(3), NRG3(8), PRKCA(3), PSEN1(8) 5238652 40 38 40 11 16 2 10 4 8 0 0.549 1.000 1.000 535 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(5), B3GNT7(1), B4GALT1(4), B4GALT2(1), B4GALT3(5), B4GALT4(2), CHST1(2), CHST2(1), CHST4(3), CHST6(1), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1) 7249622 43 38 42 31 21 0 9 9 4 0 0.997 1.000 1.000 536 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(5), ALOX15B(3), ALOX5(4), DPEP1(2), GGT1(5), LTA4H(3), PLA2G2A(2), PLA2G6(4), PTGDS(1), PTGIS(2), PTGS1(2), PTGS2(6), TBXAS1(3) 8658093 44 37 44 24 20 2 10 5 7 0 0.915 1.000 1.000 537 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(2), GPR161(8), GPR171(3), GPR18(3), GPR39(4), GPR45(4), GPR65(3), GPR68(5), GPR75(9) 5743118 41 37 40 18 19 3 9 5 5 0 0.461 1.000 1.000 538 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(4), AASDH(13), AASS(11), KARS(11) 4073260 39 37 39 12 24 3 7 3 2 0 0.787 1.000 1.000 539 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA2(2), PSMA3(1), PSMA4(4), PSMA5(5), PSMA6(6), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(1), PSMB7(2), PSMB8(4), PSMB9(2) 5099611 41 37 40 13 25 1 8 5 2 0 0.647 1.000 1.000 540 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(5), POLR2A(13), POLR2B(11), POLR2C(4), POLR2D(1), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(2), POLRMT(5) 7771103 48 37 48 25 30 2 5 6 5 0 0.984 1.000 1.000 541 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(15), HK2(11), HK3(8), IMPA1(1), PGM1(3), PGM3(2), TGDS(3) 5940854 44 37 43 23 19 3 11 2 9 0 0.970 1.000 1.000 542 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(12), GNB1(7), PRKACB(4), PRKACG(2), PRKAR1A(3), PRKAR1B(3), PRKAR2A(5), PRKAR2B(5), PRKCA(3) 5599472 48 36 47 12 22 5 11 5 5 0 0.373 1.000 1.000 543 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(12), ALAS2(5), CPO(3), FECH(3), GATA1(6), HBB(1), UROD(4), UROS(4) 4456460 43 36 43 15 19 4 4 5 11 0 0.771 1.000 1.000 544 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(7), FADS2(2), PLA2G12B(1), PLA2G1B(4), PLA2G2A(2), PLA2G2E(4), PLA2G2F(1), PLA2G3(6), PLA2G4A(1), PLA2G5(1), PLA2G6(4) 5864885 40 36 40 23 17 0 10 4 9 0 0.982 1.000 1.000 545 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(3), CSF1(4), CSF3(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(2), IL10(1), IL12A(1), IL12B(3), IL15(1), IL1A(1), IL2(1), IL5(1), IL6(4), IL7(1), LTA(1), TGFB1(3), TGFB3(1), TNF(4) 7668150 40 36 40 16 23 0 10 3 4 0 0.571 1.000 1.000 546 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(9), HSD17B1(1), HSD17B2(6), HSD17B3(1), HSD17B4(5), HSD17B7(3), HSD3B1(5), HSD3B2(5) 4720980 38 36 38 15 22 2 5 5 4 0 0.775 1.000 1.000 547 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(7), MAPK14(3), MAPK8(5), NFKB1(3), RELA(6), TNFRSF13B(1), TNFRSF13C(3), TNFRSF17(2), TNFSF13(2), TNFSF13B(5), TRAF2(5), TRAF3(2), TRAF5(1), TRAF6(1) 8408660 46 36 46 14 30 1 7 2 6 0 0.554 1.000 1.000 548 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(21), GNA12(3), PRKACB(4), PRKACG(2), PRKAG1(3), PRKAR2A(5), PRKAR2B(5) 5886779 43 35 43 12 22 1 8 5 7 0 0.591 1.000 1.000 549 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(4), HDAC9(8), MEF2A(7), MEF2B(3), MEF2C(5), MEF2D(3), MYOD1(1), YWHAH(2) 4358814 38 35 38 15 17 5 5 4 7 0 0.851 1.000 1.000 550 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(6), CREM(3), FHL5(4), FSHB(1), FSHR(5), GNAS(12), XPO1(7) 5604723 38 34 38 16 21 0 7 4 6 0 0.916 1.000 1.000 551 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(10), CS(3), MDH1(3), ME1(5), PC(10), PDHA1(5), SLC25A1(1), SLC25A11(2) 5386137 39 34 39 25 21 0 11 4 3 0 0.983 1.000 1.000 552 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(3), NFKBIA(6), PLCB1(17), PRKCA(3), RELA(6) 4778112 38 34 38 11 25 1 8 3 1 0 0.526 1.000 1.000 553 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(7), BAD(3), BAK1(2), BAX(2), BCL10(3), BCL2L1(4), BCL2L11(3), BID(2), CASP9(6), CES1(4) 6211003 36 34 35 11 9 5 9 2 11 0 0.857 1.000 1.000 554 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(2), CTH(5), GGT1(5), MARS(3), MARS2(5), MAT1A(4), MAT2B(1), PAPSS1(4), PAPSS2(2), SCLY(2), SEPHS1(2) 7181033 37 34 37 21 18 2 12 1 4 0 0.965 1.000 1.000 555 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7) 4626946 35 33 34 14 15 1 8 5 6 0 0.697 1.000 1.000 556 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(6), CHAT(5), CHKA(5), PCYT1A(2), PDHA1(5), PDHA2(6), PEMT(1), SLC18A3(5) 3996273 35 33 35 22 12 2 14 4 3 0 0.983 1.000 1.000 557 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(6), ALDH1A2(6), ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH9A1(7) 4626946 35 33 34 14 15 1 8 5 6 0 0.697 1.000 1.000 558 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(3), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST8SIA1(3) 6224947 35 33 35 17 15 1 12 3 4 0 0.874 1.000 1.000 559 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(4), IL1B(3), MST1(10), MST1R(16), TNF(4) 3802040 38 33 38 24 16 2 9 3 8 0 0.981 1.000 1.000 560 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP14(4), MMP2(7), MMP9(6), RECK(8), TIMP1(2), TIMP2(4), TIMP4(3) 4122794 34 33 34 20 18 3 9 3 1 0 0.980 1.000 1.000 561 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(3), CDK5R1(5), EGR1(7), KLK2(1), MAP2K1(3), MAP2K2(5), MAPK3(8), NGFR(4), RAF1(4) 4505889 40 32 40 22 15 3 10 6 6 0 0.965 1.000 1.000 562 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(7), CYCS(1), GPD2(10), NDUFA1(1), SDHA(9), SDHB(2), SDHC(2), SDHD(4), UQCRC1(2) 3866268 38 32 38 11 18 2 12 2 4 0 0.591 1.000 1.000 563 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(3), GPI(4), HK1(15), PFKL(2), PGAM1(1), PGK1(2), PKLR(8), TPI1(1) 5368723 39 32 39 22 17 1 12 4 5 0 0.946 1.000 1.000 564 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(2), ENO3(4), FARS2(1), GOT1(2), PAH(11), TAT(5), YARS(5) 4853154 33 32 33 12 11 1 5 7 9 0 0.692 1.000 1.000 565 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(5), CCNH(4), CDC25A(5), CDC25B(2), CDC25C(2), CDK7(6), MNAT1(4), SHH(6), XPO1(7) 5052462 41 32 40 16 28 2 5 1 5 0 0.929 1.000 1.000 566 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9) 6104608 34 32 34 16 9 2 9 6 8 0 0.957 1.000 1.000 567 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(6), JAK1(9), JAK2(8), TYK2(9) 6104608 34 32 34 16 9 2 9 6 8 0 0.957 1.000 1.000 568 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(2), CD4(3), FYN(7), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(19), ZAP70(3) 5270758 43 32 43 21 18 0 14 7 4 0 0.955 1.000 1.000 569 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(5), NDUFA5(1), NDUFA8(4), NDUFB2(1), NDUFB4(2), NDUFB5(3), NDUFB6(3), NDUFS1(5), NDUFS2(3), NDUFV1(4), NDUFV2(6) 4039204 38 32 36 12 24 0 8 2 4 0 0.737 1.000 1.000 570 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(2), CSF3(1), EPO(2), FLT3(10), IGF1(2), IL1A(1), IL6(4), KITLG(5), TGFB1(3), TGFB3(1) 4762675 31 31 31 11 19 1 7 0 4 0 0.597 1.000 1.000 571 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(3), FUT2(6), FUT9(3), GLA(3), HEXA(3), HEXB(2), NAGA(3), ST3GAL1(1), ST3GAL2(3), ST3GAL4(1), ST8SIA1(3) 5858469 32 31 32 17 12 1 11 3 5 0 0.922 1.000 1.000 572 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(5), FH(7), IDH1(9), IDH2(2), MDH1(3), SDHB(2), SUCLA2(2) 5199412 34 31 34 14 19 2 5 5 3 0 0.820 1.000 1.000 573 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(5), ACAT2(1), BDH2(3), HMGCL(1), HMGCS1(9), HMGCS2(7), OXCT1(4), OXCT2(2) 4204082 32 30 32 12 16 2 6 5 3 0 0.827 1.000 1.000 574 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(5), CDC25A(5), CDC25B(2), CDC25C(2), CSK(7), GRB2(3), PRKCA(3), PTPRA(2), SRC(5) 5374586 34 30 34 24 21 2 9 2 0 0 0.997 1.000 1.000 575 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 ARF3(1), CCND1(4), CDK2(1), CDK4(6), CDKN1B(6), CFL1(1), E2F1(3), E2F2(4), MDM2(6), PRB1(2) 3879631 34 29 33 16 16 1 6 2 9 0 0.947 1.000 1.000 576 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), CKM(5), EIF4E(2), FBL(2), GPT(2), LDHB(2), LDHC(4), MAPK14(3), NCL(3) 5229814 29 29 29 15 18 2 6 1 2 0 0.953 1.000 1.000 577 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(5), CLOCK(8), CRY1(3), CRY2(4), CSNK1E(3), PER1(6) 4876676 29 28 29 11 12 0 9 2 6 0 0.864 1.000 1.000 578 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(6), GNAS(12), GNB1(7), PRKACA(2), PRKAR1A(3) 3861208 30 28 29 14 15 3 7 2 3 0 0.887 1.000 1.000 579 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3A2(3), ALDH7A1(1), ALDH9A1(7), MIOX(2), UGDH(5) 4923620 31 28 31 12 10 2 7 6 6 0 0.693 1.000 1.000 580 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(2), FOS(4), FYN(7), JUN(4), MAPK14(3), THBS1(8) 4319310 31 28 29 13 14 0 9 4 4 0 0.895 1.000 1.000 581 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), HSD3B7(2), PON1(6), PON2(2), PON3(3), RDH12(2), RDH13(1) 5235485 32 27 30 18 11 0 13 2 6 0 0.949 1.000 1.000 582 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6) 3691193 26 26 24 17 13 2 6 1 4 0 0.903 1.000 1.000 583 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(3), B4GALT7(1), HS3ST1(1), HS3ST2(5), HS3ST3A1(3), HS3ST3B1(1), XYLT1(6), XYLT2(6) 3691193 26 26 24 17 13 2 6 1 4 0 0.903 1.000 1.000 584 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 6 LPL(4), NR3C1(6), PPARG(13), TNF(4) 2844644 27 26 24 13 15 0 5 2 5 0 0.931 1.000 1.000 585 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(3), FUT2(6), FUT9(3), GCNT2(10), ST8SIA1(3) 3559098 28 25 28 13 11 1 8 5 3 0 0.839 1.000 1.000 586 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(4), AASS(11), KARS(11) 2758501 26 25 26 11 19 1 4 1 1 0 0.947 1.000 1.000 587 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(2), CHST12(3), PAPSS1(4), PAPSS2(2), SULT1A1(3), SULT1A2(1), SULT1E1(1), SULT2A1(4), SULT2B1(2), SUOX(3) 5384806 27 25 26 20 16 2 4 4 1 0 0.997 1.000 1.000 588 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(4), B4GALT2(1), B4GALT3(5), FUT8(7), ST3GAL1(1), ST3GAL2(3), ST3GAL3(3), ST3GAL4(1) 4571457 28 25 28 13 14 0 6 5 3 0 0.834 1.000 1.000 589 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 FOS(4), JUN(4), KEAP1(9), MAFG(1), MAFK(1), MAPK14(3), MAPK8(5), PRKCA(3) 4379987 30 24 28 19 17 0 5 2 6 0 0.993 1.000 1.000 590 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(3), CDO1(2), CSAD(3), GAD1(8), GAD2(6), GGT1(5) 3329217 27 24 27 14 11 2 8 2 4 0 0.932 1.000 1.000 591 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(6), PARK2(4), SNCA(1), SNCAIP(8), UBE2E2(1), UBE2F(1), UBE2L3(2), UBE2L6(2) 3754340 25 23 25 10 11 3 3 3 5 0 0.859 1.000 1.000 592 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(5), ACAT2(1), ECHS1(1), EHHADH(6), GCDH(6), HADHA(4), SDHB(2), SDS(2) 4551112 27 22 27 12 18 1 2 1 5 0 0.910 1.000 1.000 593 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(3), CD3E(2), CD3G(2), CD4(3), CD58(1), CD8A(2), CSF3(1), IL6(4), KITLG(5) 3612454 25 22 25 13 11 2 7 1 4 0 0.920 1.000 1.000 594 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(8), HDC(6), TH(2), TPH1(3) 3446149 23 22 23 12 11 1 6 1 4 0 0.913 1.000 1.000 595 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(3), DHRS3(3), DHRS7(3), DHRSX(5), ESCO1(3), ESCO2(3), NAT6(1), PNPLA3(4), SH3GLB1(1) 9685560 27 21 26 12 10 1 11 2 3 0 0.948 1.000 1.000 596 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(7), BMPR1A(3), BMPR1B(5), BMPR2(9) 3642933 24 21 23 10 13 1 3 1 6 0 0.902 1.000 1.000 597 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(5), ALPL(4), ALPP(3), FPGS(4), GCH1(2), GGH(3) 3683789 21 20 21 12 10 0 8 1 2 0 0.845 1.000 1.000 598 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(12), PRKCA(3), PTK2B(6) 3907826 22 20 22 14 11 2 5 2 2 0 0.944 1.000 1.000 599 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(3), CASP8(14), CFL1(1), CFLAR(2) 2251441 20 20 20 10 10 1 2 2 5 0 0.907 1.000 1.000 600 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(4), MYC(2), SP1(10), SP3(3), WT1(4) 3627151 23 20 23 14 10 3 1 5 4 0 0.988 1.000 1.000 601 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(4), NR1I3(4), PTGS1(2), PTGS2(6) 3136003 20 19 20 12 9 3 5 2 1 0 0.920 1.000 1.000 602 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(4), COQ5(5), COQ6(7), NDUFA12(1), NDUFA13(3) 2310212 22 19 22 12 13 3 2 1 3 0 0.972 1.000 1.000 603 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(3), GRIA2(7), JUND(2), PPP1R1B(5) 2161565 20 18 20 13 11 0 4 3 2 0 0.988 1.000 1.000 604 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(5), PNPO(2), PSAT1(6) 2831492 21 18 21 10 7 0 2 3 9 0 0.920 1.000 1.000 605 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(3), CD8A(2), CSF1(4), CSF3(1), EPO(2), IL2(1), IL5(1), IL6(4), IL7(1) 3489735 19 18 19 10 11 1 5 2 0 0 0.834 1.000 1.000 606 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(4), GGT1(5), SHMT1(3), SHMT2(2) 3137199 17 16 17 13 5 1 7 1 3 0 0.987 1.000 1.000 607 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(2), CTH(5), MUT(9) 2855059 17 16 17 5 11 1 2 3 0 0 0.620 1.000 1.000 608 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(4), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(4), SUOX(3) 3581651 17 16 17 12 9 1 4 2 1 0 0.994 1.000 1.000 609 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(6), ALDH1A2(6), BCMO1(3) 2281033 15 15 14 6 9 0 4 2 0 0 0.703 1.000 1.000 610 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(2), NFYB(1), NFYC(1), SP1(10), SP3(3) 2879950 17 14 17 11 8 1 1 3 4 0 0.983 1.000 1.000 611 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(6), PRKCA(3), TGM2(2) 2861448 12 12 12 12 5 0 4 2 1 0 0.995 1.000 1.000 612 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(6), CD28(4), CD3E(2), CD3G(2), CD4(3) 1881739 17 12 17 11 6 1 4 4 2 0 0.948 1.000 1.000 613 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(4), HSD3B7(2), RDH12(2), RDH13(1) 2776382 10 9 10 12 5 2 1 1 1 0 0.997 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(3) 1049299 6 6 6 5 3 2 1 0 0 0 0.957 1.000 1.000 615 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 960891 1 1 1 2 1 0 0 0 0 0 0.982 1.000 1.000 616 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 421699 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000