Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.059 0.241 -9999.0 0.0 -0.632 49.0 49.0 IHH -0.058 0.182 -9999.0 0.0 -0.519 52.0 52.0 SHH Np/Cholesterol/GAS1 -0.176 0.198 -9999.0 0.0 -0.345 221.0 221.0 LRPAP1 0.014 0.026 -9999.0 0.0 -0.507 1.0 1.0 dorsoventral neural tube patterning 0.175 0.197 0.343 221.0 -9999.0 0.0 221.0 SMO/beta Arrestin2 -0.05 0.169 -9999.0 0.0 -0.518 27.0 27.0 SMO -0.061 0.177 -9999.0 0.0 -0.512 35.0 35.0 AKT1 -0.005 0.086 -9999.0 0.0 -0.339 5.0 5.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.039 0.169 -9999.0 0.0 -0.568 38.0 38.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.06 0.175 -9999.0 0.0 -0.504 35.0 35.0 STIL -0.154 0.215 -9999.0 0.0 -0.463 93.0 93.0 DHH N/PTCH2 -0.019 0.129 -9999.0 0.0 -0.419 38.0 38.0 DHH N/PTCH1 -0.037 0.162 -9999.0 0.0 -0.502 26.0 26.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.123 -9999.0 0.0 -0.569 19.0 19.0 PTHLH -0.111 0.365 -9999.0 0.0 -1.03 49.0 49.0 determination of left/right symmetry -0.06 0.175 -9999.0 0.0 -0.504 35.0 35.0 PIK3R1 0.014 0.029 -9999.0 0.0 -0.569 1.0 1.0 skeletal system development -0.109 0.36 -9999.0 0.0 -1.013 49.0 49.0 IHH N/Hhip -0.142 0.231 -9999.0 0.0 -0.476 121.0 121.0 DHH N/Hhip -0.111 0.206 -9999.0 0.0 -0.423 121.0 121.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.06 0.175 -9999.0 0.0 -0.504 35.0 35.0 pancreas development -0.139 0.255 -9999.0 0.0 -0.567 107.0 107.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.022 0.021 -9999.0 0.0 -0.408 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.125 0.249 -9999.0 0.0 -0.568 98.0 98.0 somite specification -0.06 0.175 -9999.0 0.0 -0.504 35.0 35.0 SHH Np/Cholesterol/PTCH1 -0.123 0.192 -9999.0 0.0 -0.449 62.0 62.0 SHH Np/Cholesterol/PTCH2 -0.113 0.174 -9999.0 0.0 -0.321 163.0 163.0 SHH Np/Cholesterol/Megalin -0.157 0.199 -9999.0 0.0 -0.347 198.0 198.0 SHH -0.137 0.207 -9999.0 0.0 -0.409 150.0 150.0 catabolic process -0.032 0.158 -9999.0 0.0 -0.525 20.0 20.0 SMO/Vitamin D3 -0.119 0.201 -9999.0 0.0 -0.456 66.0 66.0 SHH Np/Cholesterol/Hhip -0.184 0.218 -9999.0 0.0 -0.375 212.0 212.0 LRP2 -0.094 0.21 -9999.0 0.0 -0.507 84.0 84.0 receptor-mediated endocytosis -0.15 0.211 -9999.0 0.0 -0.459 91.0 91.0 SHH Np/Cholesterol/BOC -0.128 0.182 -9999.0 0.0 -0.329 176.0 176.0 SHH Np/Cholesterol/CDO -0.143 0.184 -9999.0 0.0 -0.329 194.0 194.0 mesenchymal cell differentiation 0.183 0.216 0.373 212.0 -9999.0 0.0 212.0 mol:Vitamin D3 -0.121 0.194 -9999.0 0.0 -0.45 62.0 62.0 IHH N/PTCH2 -0.043 0.146 -9999.0 0.0 -0.415 41.0 41.0 CDON -0.066 0.203 -9999.0 0.0 -0.569 57.0 57.0 IHH N/PTCH1 -0.032 0.159 -9999.0 0.0 -0.531 20.0 20.0 Megalin/LRPAP1 -0.057 0.153 -9999.0 0.0 -0.355 85.0 85.0 PTCH2 -0.013 0.126 -9999.0 0.0 -0.569 20.0 20.0 SHH Np/Cholesterol -0.114 0.155 -9999.0 0.0 -0.317 150.0 150.0 PTCH1 -0.033 0.158 -9999.0 0.0 -0.526 20.0 20.0 HHIP -0.14 0.255 -9999.0 0.0 -0.568 107.0 107.0