Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	155.0	7954.0	51.0	-0.873	0.016	1000.0	-1000.0	-0.13	-1000.0
Glypican 2 network	116.0	465.0	4.0	-0.164	-0.126	1000.0	-1000.0	-0.011	-1000.0
Aurora B signaling	108.0	7288.0	67.0	-0.512	0.016	1000.0	-1000.0	-0.052	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	86.0	5895.0	68.0	-0.726	0.359	1000.0	-1000.0	-0.09	-1000.0
Signaling events regulated by Ret tyrosine kinase	80.0	6583.0	82.0	-0.312	0.016	1000.0	-1000.0	-0.072	-1000.0
Signaling mediated by p38-alpha and p38-beta	72.0	3210.0	44.0	-0.248	0.016	1000.0	-1000.0	-0.044	-1000.0
Nongenotropic Androgen signaling	72.0	3780.0	52.0	-0.258	0.145	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by the Hedgehog family	71.0	3702.0	52.0	-0.184	0.183	1000.0	-1000.0	-0.039	-1000.0
IL4-mediated signaling events	67.0	6124.0	91.0	-0.781	0.553	1000.0	-1000.0	-0.112	-1000.0
Endothelins	67.0	6474.0	96.0	-0.337	0.04	1000.0	-1000.0	-0.061	-1000.0
Reelin signaling pathway	59.0	3326.0	56.0	-0.236	0.041	1000.0	-1000.0	-0.068	-1000.0
TCGA08_p53	59.0	416.0	7.0	-0.178	0.081	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	58.0	4545.0	78.0	-0.258	0.088	1000.0	-1000.0	-0.056	-1000.0
Thromboxane A2 receptor signaling	56.0	5953.0	105.0	-0.209	0.038	1000.0	-1000.0	-0.057	-1000.0
Aurora C signaling	56.0	392.0	7.0	-0.22	0.0	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	56.0	4827.0	85.0	-0.368	0.051	1000.0	-1000.0	-0.033	-1000.0
IGF1 pathway	55.0	3142.0	57.0	-0.251	0.047	1000.0	-1000.0	-0.077	-1000.0
TCGA08_retinoblastoma	54.0	433.0	8.0	-0.255	0.069	1000.0	-1000.0	-0.014	-1000.0
IL23-mediated signaling events	52.0	3155.0	60.0	-0.608	0.016	1000.0	-1000.0	-0.106	-1000.0
Ephrin A  reverse signaling	50.0	350.0	7.0	-0.071	-0.0	1000.0	-1000.0	-0.018	-1000.0
p75(NTR)-mediated signaling	50.0	6318.0	125.0	-0.172	0.047	1000.0	-1000.0	-0.085	-1000.0
Plasma membrane estrogen receptor signaling	50.0	4313.0	86.0	-0.258	0.129	1000.0	-1000.0	-0.071	-1000.0
Fc-epsilon receptor I signaling in mast cells	49.0	4811.0	97.0	-0.197	0.041	1000.0	-1000.0	-0.076	-1000.0
HIF-1-alpha transcription factor network	48.0	3712.0	76.0	-0.35	0.035	1000.0	-1000.0	-0.056	-1000.0
Rapid glucocorticoid signaling	47.0	957.0	20.0	-0.239	0.037	1000.0	-1000.0	-0.015	-1000.0
Integrins in angiogenesis	46.0	3877.0	84.0	-0.275	0.033	1000.0	-1000.0	-0.076	-1000.0
Syndecan-1-mediated signaling events	44.0	1526.0	34.0	-0.28	0.016	1000.0	-1000.0	-0.04	-1000.0
Glypican 1 network	44.0	2117.0	48.0	-0.25	0.036	1000.0	-1000.0	-0.021	-1000.0
IL6-mediated signaling events	44.0	3321.0	75.0	-0.245	0.069	1000.0	-1000.0	-0.055	-1000.0
Ras signaling in the CD4+ TCR pathway	44.0	760.0	17.0	-0.157	0.021	1000.0	-1000.0	-0.022	-1000.0
Glucocorticoid receptor regulatory network	43.0	4986.0	114.0	-0.602	0.269	1000.0	-1000.0	-0.061	-1000.0
Calcium signaling in the CD4+ TCR pathway	43.0	1361.0	31.0	-0.294	0.016	1000.0	-1000.0	-0.067	-1000.0
BMP receptor signaling	42.0	3415.0	81.0	-0.323	0.053	1000.0	-1000.0	-0.08	-1000.0
amb2 Integrin signaling	41.0	3441.0	82.0	-0.329	0.021	1000.0	-1000.0	-0.07	-1000.0
TCR signaling in naïve CD8+ T cells	41.0	3828.0	93.0	-0.14	0.063	1000.0	-1000.0	-0.071	-1000.0
LPA receptor mediated events	40.0	4095.0	102.0	-0.241	0.029	1000.0	-1000.0	-0.073	-1000.0
S1P1 pathway	39.0	1405.0	36.0	-0.307	0.016	1000.0	-1000.0	-0.048	-1000.0
PDGFR-alpha signaling pathway	38.0	1688.0	44.0	-0.34	0.033	1000.0	-1000.0	-0.049	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	38.0	4577.0	120.0	-0.322	0.185	1000.0	-1000.0	-0.067	-1000.0
S1P5 pathway	37.0	633.0	17.0	-0.169	0.114	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Cones	35.0	1361.0	38.0	-0.123	0.019	1000.0	-1000.0	-0.046	-1000.0
JNK signaling in the CD4+ TCR pathway	35.0	598.0	17.0	-0.154	0.022	1000.0	-1000.0	-0.017	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	35.0	1826.0	52.0	-0.314	0.028	1000.0	-1000.0	-0.037	-1000.0
Osteopontin-mediated events	34.0	1315.0	38.0	-0.191	0.017	1000.0	-1000.0	-0.074	-1000.0
LPA4-mediated signaling events	32.0	393.0	12.0	-0.165	0.022	1000.0	-1000.0	-0.017	-1000.0
Aurora A signaling	32.0	1947.0	60.0	-0.36	0.031	1000.0	-1000.0	-0.035	-1000.0
S1P4 pathway	32.0	822.0	25.0	-0.169	0.032	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	31.0	2376.0	76.0	-0.244	0.032	1000.0	-1000.0	-0.034	-1000.0
IL12-mediated signaling events	31.0	2730.0	87.0	-0.417	0.037	1000.0	-1000.0	-0.103	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	31.0	1690.0	54.0	-0.197	0.031	1000.0	-1000.0	-0.083	-1000.0
Angiopoietin receptor Tie2-mediated signaling	31.0	2806.0	88.0	-0.234	0.041	1000.0	-1000.0	-0.093	-1000.0
BCR signaling pathway	30.0	3065.0	99.0	-0.176	0.038	1000.0	-1000.0	-0.078	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	28.0	981.0	34.0	-0.053	0.016	1000.0	-1000.0	-0.049	-1000.0
S1P3 pathway	28.0	1180.0	42.0	-0.168	0.032	1000.0	-1000.0	-0.024	-1000.0
Syndecan-2-mediated signaling events	27.0	1904.0	69.0	-0.091	0.03	1000.0	-1000.0	-0.032	-1000.0
Arf6 signaling events	27.0	1705.0	62.0	-0.236	0.03	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	26.0	78.0	3.0	-0.022	-1000.0	1000.0	-1000.0	-0.008	-1000.0
Wnt signaling	25.0	178.0	7.0	-0.06	0.016	1000.0	-1000.0	-0.019	-1000.0
Presenilin action in Notch and Wnt signaling	24.0	1469.0	61.0	-0.187	0.045	1000.0	-1000.0	-0.064	-1000.0
FAS signaling pathway (CD95)	24.0	1152.0	47.0	-0.561	0.02	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	22.0	1158.0	51.0	-0.187	0.081	1000.0	-1000.0	-0.038	-1000.0
Syndecan-4-mediated signaling events	22.0	1531.0	67.0	-0.188	0.017	1000.0	-1000.0	-0.074	-1000.0
Visual signal transduction: Rods	22.0	1185.0	52.0	-0.208	0.016	1000.0	-1000.0	-0.076	-1000.0
ErbB4 signaling events	20.0	1439.0	69.0	-0.232	0.039	1000.0	-1000.0	-0.072	-1000.0
Noncanonical Wnt signaling pathway	20.0	535.0	26.0	-0.092	0.016	1000.0	-1000.0	-0.04	-1000.0
ErbB2/ErbB3 signaling events	19.0	1276.0	65.0	-0.232	0.027	1000.0	-1000.0	-0.056	-1000.0
Sphingosine 1-phosphate (S1P) pathway	19.0	533.0	28.0	-0.169	0.029	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	19.0	1693.0	85.0	-0.224	0.024	1000.0	-1000.0	-0.064	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19.0	643.0	33.0	-0.28	0.047	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	18.0	832.0	46.0	-0.191	0.096	1000.0	-1000.0	-0.034	-1000.0
Effects of Botulinum toxin	18.0	475.0	26.0	-0.076	0.016	1000.0	-1000.0	-0.053	-1000.0
Regulation of Androgen receptor activity	16.0	1140.0	70.0	-0.211	0.03	1000.0	-1000.0	-0.049	-1000.0
Caspase cascade in apoptosis	15.0	1157.0	74.0	-0.055	0.044	1000.0	-1000.0	-0.028	-1000.0
Cellular roles of Anthrax toxin	15.0	592.0	39.0	-0.101	0.017	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	1002.0	65.0	-0.169	0.066	1000.0	-1000.0	-0.046	-1000.0
IL27-mediated signaling events	15.0	794.0	51.0	-0.245	0.027	1000.0	-1000.0	-0.058	-1000.0
EGFR-dependent Endothelin signaling events	15.0	334.0	21.0	-0.069	0.023	1000.0	-1000.0	-0.061	-1000.0
Nectin adhesion pathway	14.0	922.0	63.0	-0.05	0.03	1000.0	-1000.0	-0.065	-1000.0
IL2 signaling events mediated by STAT5	14.0	317.0	22.0	-0.12	0.069	1000.0	-1000.0	-0.028	-1000.0
Regulation of nuclear SMAD2/3 signaling	12.0	1763.0	136.0	-0.198	0.069	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by PTP1B	12.0	926.0	76.0	-0.135	0.035	1000.0	-1000.0	-0.066	-1000.0
IL2 signaling events mediated by PI3K	12.0	742.0	58.0	-0.21	0.058	1000.0	-1000.0	-0.063	-1000.0
Regulation of p38-alpha and p38-beta	12.0	677.0	54.0	-0.155	0.042	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class III	11.0	459.0	40.0	-0.229	0.026	1000.0	-1000.0	-0.034	-1000.0
IL1-mediated signaling events	11.0	700.0	62.0	-0.094	0.075	1000.0	-1000.0	-0.084	-1000.0
Syndecan-3-mediated signaling events	11.0	385.0	35.0	-0.129	0.047	1000.0	-1000.0	-0.032	-1000.0
Regulation of Telomerase	11.0	1125.0	102.0	-0.172	0.039	1000.0	-1000.0	-0.083	-1000.0
Insulin Pathway	11.0	875.0	74.0	-0.255	0.042	1000.0	-1000.0	-0.076	-1000.0
Ceramide signaling pathway	10.0	776.0	76.0	-0.245	0.046	1000.0	-1000.0	-0.028	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	10.0	878.0	83.0	-0.275	0.043	1000.0	-1000.0	-0.063	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	49.0	5.0	-0.003	0.01	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	9.0	645.0	68.0	-0.206	0.061	1000.0	-1000.0	-0.039	-1000.0
Ephrin B reverse signaling	9.0	465.0	48.0	-0.053	0.02	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by PRL	9.0	319.0	34.0	-0.099	0.026	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling events	9.0	45.0	5.0	-0.004	0.018	1000.0	-1000.0	-0.021	-1000.0
BARD1 signaling events	8.0	506.0	57.0	-0.17	0.045	1000.0	-1000.0	-0.053	-1000.0
IFN-gamma pathway	8.0	561.0	68.0	-0.171	0.054	1000.0	-1000.0	-0.073	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	127.0	15.0	0.0	0.032	1000.0	-1000.0	-0.019	-1000.0
EPHB forward signaling	8.0	761.0	85.0	-0.047	0.04	1000.0	-1000.0	-0.085	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	8.0	642.0	74.0	-0.245	0.077	1000.0	-1000.0	-0.078	-1000.0
PDGFR-beta signaling pathway	8.0	843.0	97.0	-0.062	0.054	1000.0	-1000.0	-0.078	-1000.0
PLK2 and PLK4 events	7.0	22.0	3.0	0.003	0.016	1000.0	-1000.0	-0.013	-1000.0
EPO signaling pathway	7.0	423.0	55.0	-0.046	0.059	1000.0	-1000.0	-0.08	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	292.0	37.0	-0.027	0.036	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	341.0	45.0	-0.03	0.068	1000.0	-1000.0	-0.07	-1000.0
Arf6 trafficking events	7.0	518.0	71.0	-0.406	0.05	1000.0	-1000.0	-0.063	-1000.0
TRAIL signaling pathway	6.0	328.0	48.0	-0.01	0.051	1000.0	-1000.0	-0.048	-1000.0
Retinoic acid receptors-mediated signaling	6.0	401.0	58.0	-0.079	0.033	1000.0	-1000.0	-0.061	-1000.0
TCGA08_rtk_signaling	5.0	155.0	26.0	-0.065	0.048	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	388.0	76.0	-0.02	0.058	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class II	4.0	317.0	75.0	-0.089	0.039	1000.0	-1000.0	-0.037	-1000.0
p38 MAPK signaling pathway	4.0	176.0	44.0	-0.04	0.046	1000.0	-1000.0	-0.053	-1000.0
FoxO family signaling	3.0	206.0	64.0	-0.06	0.097	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	115.0	36.0	-0.036	0.037	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	414.0	125.0	-0.05	0.097	1000.0	-1000.0	-0.08	-1000.0
Class I PI3K signaling events	3.0	288.0	73.0	-0.06	0.042	1000.0	-1000.0	-0.055	-1000.0
Canonical NF-kappaB pathway	2.0	105.0	39.0	-0.019	0.091	1000.0	-1000.0	-0.069	-1000.0
Circadian rhythm pathway	2.0	54.0	22.0	-0.016	0.053	1000.0	-1000.0	-0.029	-1000.0
Insulin-mediated glucose transport	2.0	66.0	32.0	-0.138	0.042	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	2.0	109.0	53.0	-0.008	0.04	1000.0	-1000.0	-0.054	-1000.0
ceramide signaling pathway	2.0	115.0	49.0	-0.02	0.051	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	2.0	122.0	43.0	-0.155	0.158	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in keratinocytes	2.0	101.0	43.0	-0.046	0.048	1000.0	-1000.0	-0.057	-1000.0
Atypical NF-kappaB pathway	1.0	47.0	31.0	-0.0	0.055	1000.0	-1000.0	-0.022	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	39.0	27.0	-0.001	0.039	1000.0	-1000.0	-0.047	-1000.0
VEGFR1 specific signals	1.0	102.0	56.0	-0.05	0.072	1000.0	-1000.0	-0.04	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	14.0	23.0	0.008	0.054	1000.0	-1000.0	-0.04	-1000.0
Arf6 downstream pathway	0.0	17.0	43.0	-0.038	0.039	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	0.0	84.0	104.0	-0.032	0.066	1000.0	-1000.0	-0.058	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.0	0.04	1000.0	-1000.0	-0.03	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.047	1000.0	-1000.0	-0.018	-1000.0
Total	3562	205923	7203	-24.4503619578	-993.201552468	131000	-131000	-6.73115960291	-131000