Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.011 0.064 0.207 20.0 -0.213 3.0 23.0 KIRREL 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.011 0.064 0.214 3.0 -0.207 20.0 23.0 PLCG1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.029 0.056 0.202 3.0 -0.161 18.0 21.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.004 0.047 -9999.0 0.0 -0.193 15.0 15.0 FYN -0.002 0.084 0.212 30.0 -0.157 16.0 46.0 mol:Ca2+ 0.029 0.052 0.195 2.0 -0.158 17.0 19.0 mol:DAG 0.029 0.053 0.198 2.0 -0.159 17.0 19.0 NPHS2 -0.015 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.029 0.053 0.198 2.0 -0.159 17.0 19.0 regulation of endocytosis 0.019 0.053 0.184 3.0 -0.149 18.0 21.0 Nephrin/NEPH1/podocin/Cholesterol 0.019 0.052 0.188 3.0 -0.151 20.0 23.0 establishment of cell polarity 0.011 0.064 0.213 3.0 -0.207 20.0 23.0 Nephrin/NEPH1/podocin/NCK1-2 0.029 0.054 -9999.0 0.0 -0.151 15.0 15.0 Nephrin/NEPH1/beta Arrestin2 0.021 0.055 0.191 3.0 -0.15 18.0 21.0 NPHS1 0.007 0.05 0.296 6.0 -9999.0 0.0 6.0 Nephrin/NEPH1/podocin 0.018 0.053 0.19 3.0 -0.143 25.0 28.0 TJP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.03 0.053 0.202 2.0 -0.159 17.0 19.0 CD2AP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.029 0.057 0.202 3.0 -0.157 20.0 23.0 GRB2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.006 0.077 0.211 24.0 -0.147 18.0 42.0 cytoskeleton organization -0.016 0.054 0.183 8.0 -0.196 14.0 22.0 Nephrin/NEPH1 0.012 0.045 0.175 3.0 -0.136 20.0 23.0 Nephrin/NEPH1/ZO-1 0.021 0.057 0.2 3.0 -0.165 20.0 23.0