Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.071 0.048 0.165 2.0 -0.165 1.0 3.0 epithelial cell differentiation 0.139 0.071 0.181 218.0 -9999.0 0.0 218.0 CYFIP2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.029 0.071 0.215 11.0 -9999.0 0.0 11.0 EGFR 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 EPHA2 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.037 0.03 0.18 4.0 -9999.0 0.0 4.0 CTNNB1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.014 0.124 0.225 8.0 -0.356 24.0 32.0 CTNND1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.036 0.029 0.178 4.0 -9999.0 0.0 4.0 regulation of calcium-dependent cell-cell adhesion 0.034 0.032 0.167 2.0 -9999.0 0.0 2.0 EGF 0.003 0.067 -9999.0 0.0 -0.29 14.0 14.0 NCKAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.079 0.078 0.217 21.0 -9999.0 0.0 21.0 cortical microtubule organization 0.139 0.071 0.181 218.0 -9999.0 0.0 218.0 GO:0000145 0.023 0.025 0.164 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.152 0.078 0.196 218.0 -9999.0 0.0 218.0 MLLT4 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.036 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.015 0.02 0.157 1.0 -9999.0 0.0 1.0 PVRL2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.036 0.03 0.18 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.037 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.255 0.097 0.294 251.0 -9999.0 0.0 251.0 EGFR/EGFR/EGF/EGF 0.085 0.069 0.211 2.0 -0.134 4.0 6.0 RhoA/GDP 0.121 0.062 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.027 0.028 0.167 4.0 -9999.0 0.0 4.0 IGF-1R heterotetramer 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 GIT1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.018 0.026 -9999.0 0.0 -0.29 2.0 2.0 IGF1 -0.079 0.145 -9999.0 0.0 -0.29 93.0 93.0 DIAPH1 -0.006 0.134 -9999.0 0.0 -0.527 9.0 9.0 Wnt receptor signaling pathway -0.139 0.071 -9999.0 0.0 -0.181 218.0 218.0 RHOA 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.003 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.028 0.028 0.168 4.0 -9999.0 0.0 4.0 EFNA1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.014 0.021 0.155 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.089 0.056 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.034 0.032 0.169 2.0 -9999.0 0.0 2.0 HGF/MET 0.072 0.081 0.234 1.0 -0.15 2.0 3.0 HGF -0.016 0.101 0.294 1.0 -0.29 34.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.071 0.048 0.163 1.0 -0.166 1.0 2.0 actin cable formation 0.074 0.119 0.245 72.0 -0.23 3.0 75.0 KIAA1543 0.023 0.025 0.166 4.0 -9999.0 0.0 4.0 KIFC3 0.036 0.027 0.191 2.0 -9999.0 0.0 2.0 NCK1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.037 0.029 0.18 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.139 0.071 0.181 218.0 -9999.0 0.0 218.0 EXOC4 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.037 0.027 0.191 2.0 -9999.0 0.0 2.0 PIP5K1C 0.036 0.029 0.18 4.0 -9999.0 0.0 4.0 LIMA1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.059 0.09 0.278 21.0 -9999.0 0.0 21.0 adherens junction assembly 0.01 0.081 0.248 3.0 -0.453 5.0 8.0 IGF-1R heterotetramer/IGF1 0.035 0.102 -9999.0 0.0 -0.156 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.036 0.03 0.18 4.0 -9999.0 0.0 4.0 mol:GTP 0.035 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.055 0.08 0.201 57.0 -9999.0 0.0 57.0 cortical actin cytoskeleton stabilization 0.071 0.048 0.165 2.0 -0.165 1.0 3.0 regulation of cell-cell adhesion 0.027 0.028 0.167 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.071 0.048 0.163 1.0 -0.166 1.0 2.0