rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(4), CD3E(2), CD3G(15) 634073 21 19 8 3 1 4 2 0 14 0 0.532 0.0579 1.000 2 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(17), BMPR1A(18), BMPR1B(14), BMPR2(46) 3229801 95 69 78 13 20 14 5 20 26 10 0.0145 0.0743 1.000 3 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(8), LIPT1(11) 821172 19 17 14 0 0 3 2 3 11 0 0.0552 0.146 1.000 4 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(7) 384581 7 8 7 1 6 0 0 1 0 0 0.331 0.369 1.000 5 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(5), ALDOA(2), ALDOB(16), ALDOC(1), TPI1(3) 1926826 27 26 23 3 4 5 2 15 1 0 0.0522 0.529 1.000 6 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(3), CDO1(3), CSAD(4), GAD1(15), GAD2(15), GGT1(9) 2900087 49 43 37 8 16 6 5 11 11 0 0.0353 0.567 1.000 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(2), CDK2(5), CDK4(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(3), TP53(326) 3973129 378 245 232 89 99 90 47 65 73 4 7.33e-05 0.605 1.000 8 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(5), TPI1(3) 802771 8 8 8 1 0 0 1 7 0 0 0.397 0.709 1.000 9 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(11), ALDH1A2(17), BCMO1(5), RDH5(2) 2048461 35 32 34 7 10 8 5 8 4 0 0.0769 0.726 1.000 10 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(11), CD28(4), CD3D(4), CD3E(2), CD3G(15), CD4(4) 1777677 40 32 26 8 4 4 6 8 18 0 0.405 0.783 1.000 11 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(7), DCN(7), FMOD(8), KERA(7), LUM(12) 1873748 41 36 40 9 10 12 1 14 4 0 0.212 0.817 1.000 12 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(4), CD4(4), HLA-DRA(11), HLA-DRB1(6) 1042614 25 23 24 8 4 4 3 7 4 3 0.699 0.824 1.000 13 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4) 4134598 86 62 75 10 28 19 12 18 9 0 3.96e-05 0.856 1.000 14 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4) 4134598 86 62 75 10 28 19 12 18 9 0 3.96e-05 0.856 1.000 15 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(5), MAX(5), MYC(5), SP1(6), SP3(10), TP53(326), WT1(28) 3589323 385 247 236 101 102 96 53 63 67 4 0.000156 0.879 1.000 16 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(11), ACO2(7), FH(9), IDH1(18), IDH2(16), MDH1(8), MDH2(3), SDHB(3), SUCLA2(6) 4733585 81 73 72 16 16 20 12 21 12 0 0.0117 0.950 1.000 17 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(3), CASP8(19), CFL1(2), CFLAR(2), PDE6D(2) 1974946 30 28 28 5 5 2 3 8 12 0 0.194 0.952 1.000 18 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), IL8(5), SLPI(2) 832960 16 15 15 7 2 3 2 3 6 0 0.794 0.958 1.000 19 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPX1(4), PRKCE(4) 3921206 100 77 93 24 25 15 11 33 16 0 0.0327 0.961 1.000 20 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), SDS(3) 6313572 115 79 103 15 36 22 18 24 15 0 7.61e-06 0.963 1.000 21 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(6), GLUD1(4), GLUD2(20) 2290141 32 30 32 6 12 6 1 11 2 0 0.144 0.972 1.000 22 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(5), B3GNT1(5), FUT1(8), FUT2(6), FUT9(9), GCNT2(24), ST8SIA1(10) 2877199 67 53 62 17 20 8 8 22 8 1 0.0941 0.976 1.000 23 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(7), ACAT2(8), ACYP1(1), ECHS1(3), EHHADH(13), GCDH(6), HADHA(10), SDHB(3), SDS(3) 4069262 54 43 51 9 14 8 9 12 11 0 0.0190 0.976 1.000 24 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GGT1(9), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTM5(10), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH1(18), IDH2(16), MGST1(2), MGST2(2), MGST3(1), PGD(7) 9415599 167 104 145 29 35 35 27 45 25 0 9.21e-05 0.983 1.000 25 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(4), HGD(5) 1190363 12 10 11 3 0 1 5 4 2 0 0.300 0.986 1.000 26 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(12), ACO1(11), ACO2(7), ACSS1(6), ACSS2(9), FH(9), IDH1(18), IDH2(16), MDH1(8), MDH2(3), SUCLA2(6) 7014343 105 83 95 19 26 24 15 26 14 0 0.00133 0.989 1.000 27 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GBA3(3), GGT1(9), SHMT1(6), SHMT2(5) 1926709 24 24 22 7 6 1 3 2 12 0 0.664 0.991 1.000 28 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), HLCS(12), SPCS1(2), SPCS3(2) 1621531 21 18 19 5 8 3 1 6 3 0 0.213 0.993 1.000 29 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(12), AGT(10), AGTR1(12), AGTR2(15), BDKRB2(4), KNG1(8), NOS3(21), REN(8) 4541085 90 59 79 14 26 8 11 21 24 0 0.00525 0.995 1.000 30 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(9), CD4(4), HLA-DRA(11), HLA-DRB1(6), IL1B(4), IL4(5), IL5RA(9), IL6(5) 2640748 54 38 51 14 16 10 6 16 3 3 0.191 0.997 1.000 31 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), MIOX(3), UGDH(8) 4290041 75 57 63 13 21 17 9 14 14 0 0.0137 0.998 1.000 32 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(23), DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), TP53(326) 5103681 382 243 235 82 108 93 45 61 71 4 5.56e-06 0.998 1.000 33 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(3), EHHADH(13), HADHA(10), SDS(3) 2543336 29 26 28 7 8 3 6 6 6 0 0.205 0.999 1.000 34 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(4), CD3E(2), CD3G(15), CD4(4), FYN(15), HLA-DRA(11), HLA-DRB1(6), LCK(8), PTPRC(27), ZAP70(12) 4556155 104 76 81 27 23 21 14 13 30 3 0.157 0.999 1.000 35 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(7), ACAA2(2), ACAT1(7), ACAT2(8), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), SDS(3) 4429277 62 51 59 13 13 12 12 13 12 0 0.0329 0.999 1.000 36 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(7), CD34(7), CD3D(4), CD3E(2), CD3G(15), CD4(4), CD58(14), CD8A(1), CSF3(2), IL3(6), IL6(5), IL8(5), KITLG(3) 3373465 75 51 56 21 9 15 6 15 29 1 0.554 0.999 1.000 37 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(5), CBS(3), CTH(5), MUT(7) 2444165 23 19 23 4 9 1 6 3 4 0 0.0855 1.000 1.000 38 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP1(6), RANBP2(24), RANGAP1(4) 4139507 36 31 34 4 7 6 5 10 8 0 0.0208 1.000 1.000 39 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(2), FOSB(6), GRIA2(23), PPP1R1B(1) 1746011 32 28 32 11 13 5 3 8 3 0 0.380 1.000 1.000 40 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(11), CYP2C9(8) 1088534 19 19 18 5 2 7 2 7 1 0 0.431 1.000 1.000 41 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(5), ST6GALNAC4(3), ST8SIA1(10) 2831569 31 28 29 7 10 7 3 5 6 0 0.159 1.000 1.000 42 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(4), GBA3(3), GGT1(9), SHMT1(6), SHMT2(5) 2695334 28 27 26 9 8 1 3 3 13 0 0.741 1.000 1.000 43 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(10), BIRC3(11), CASP8(19), FADD(1), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 3920236 62 50 50 14 10 17 3 12 20 0 0.115 1.000 1.000 44 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(1), CSF1(4), CSF3(2), EPO(1), IL11(6), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), IL9(1) 3217023 47 38 44 13 14 11 4 13 4 1 0.219 1.000 1.000 45 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(4), GALT(3), UGDH(8), UGP2(10), UXS1(8) 2598375 33 30 33 7 8 1 6 8 10 0 0.416 1.000 1.000 46 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(9), HLA-DRA(11), HLA-DRB1(6), IL3(6) 1330353 33 32 29 11 7 12 1 9 1 3 0.679 1.000 1.000 47 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(12), PDXK(1), PDXP(1), PNPO(2), PSAT1(6) 2535314 22 21 21 6 6 7 3 3 3 0 0.298 1.000 1.000 48 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 2460399 25 23 22 6 10 4 1 7 3 0 0.289 1.000 1.000 49 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(12), RAB11A(3), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(3), RAB6A(4), RAB9A(2) 2211388 37 30 35 11 12 5 8 5 7 0 0.276 1.000 1.000 50 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(8), SUCLA2(6) 1061048 14 13 14 6 8 1 3 0 2 0 0.643 1.000 1.000 51 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(4), GALT(3), UGDH(8), UXS1(8) 2029445 23 22 23 6 6 1 4 5 7 0 0.606 1.000 1.000 52 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(4), IL1B(4), MST1(5), MST1R(14), TNF(1) 2643030 28 25 25 7 9 4 4 8 3 0 0.198 1.000 1.000 53 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(9), PAPSS1(4), PAPSS2(5), SULT1A2(4), SULT1E1(5), SULT2A1(4), SUOX(5) 3569533 36 26 33 7 11 5 4 9 7 0 0.172 1.000 1.000 54 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(4), PGLYRP2(7) 910750 11 10 11 6 4 1 2 3 1 0 0.851 1.000 1.000 55 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(7), ACOX1(11), ACOX3(8), ELOVL2(9), ELOVL5(3), ELOVL6(3), FADS2(10), HADHA(10), HSD17B12(3), SCD(4) 5597538 68 53 65 11 22 8 10 17 11 0 0.00393 1.000 1.000 56 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(7), ACAT2(8), OXCT1(3) 1813873 18 16 16 8 2 5 3 4 4 0 0.827 1.000 1.000 57 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(11), KARS(8) 2561211 22 19 21 5 4 1 5 8 4 0 0.429 1.000 1.000 58 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(14), ADORA2A(4), ADORA2B(5), ADORA3(14), LTB4R(1), P2RY1(5), P2RY2(6), P2RY6(5) 2663583 54 44 49 17 22 14 8 7 3 0 0.107 1.000 1.000 59 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 14 GATA3(17), IL13(2), IL4(5), MAF(9), MAP2K3(8), MAPK14(7), NFATC2(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 5066057 83 63 80 20 35 18 6 12 12 0 0.0201 1.000 1.000 60 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(4), CD4(4), CD80(4), HLA-DRA(11), HLA-DRB1(6), IL10(1), IL2(4), IL4(5) 1909167 39 30 38 12 10 7 5 10 4 3 0.488 1.000 1.000 61 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8) 2941977 39 35 36 13 5 13 6 13 2 0 0.359 1.000 1.000 62 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(13), GBA(4), GBA3(3), LPO(9), MPO(13), PRDX6(4), TPO(29) 4183716 75 58 69 18 37 11 5 11 11 0 0.0736 1.000 1.000 63 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(3), FDPS(6), IDI1(4), SQLE(1) 1611811 14 14 14 5 1 2 3 4 4 0 0.715 1.000 1.000 64 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 5 ACACA(30), ACACB(37), MCAT(3), OLAH(10), OXSM(10) 6469721 90 56 82 15 28 11 15 19 16 1 0.0105 1.000 1.000 65 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(22), CREM(10), FHL5(8), FSHB(4), FSHR(16), GNAS(35), XPO1(7) 4643789 102 75 80 26 44 27 9 15 7 0 0.0598 1.000 1.000 66 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(5), CDK7(3), MNAT1(3), SHH(3), XPO1(7) 4537450 58 46 56 13 15 11 8 19 5 0 0.0951 1.000 1.000 67 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(11), CLOCK(20), CRY1(13), CRY2(5), CSNK1E(9), PER1(12) 4314594 70 49 50 14 20 11 3 18 17 1 0.173 1.000 1.000 68 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(3), FDPS(6), GGPS1(4), IDI1(4), IDI2(3), SQLE(1) 2198213 21 21 20 6 4 2 3 5 7 0 0.562 1.000 1.000 69 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7) 6799094 108 67 101 25 18 22 20 34 13 1 0.0238 1.000 1.000 70 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(4), ITGAL(18), ITGAM(13), ITGB2(16), PECAM1(4), SELE(11), SELL(5) 5189818 76 57 78 22 28 14 8 12 14 0 0.187 1.000 1.000 71 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(12), PARK2(11), SNCA(2), SNCAIP(6), UBE2E2(3), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5) 3325112 45 35 44 13 13 2 9 14 7 0 0.286 1.000 1.000 72 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4) 6833745 109 79 95 28 28 28 16 26 11 0 0.0373 1.000 1.000 73 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(11), DLL1(6), FURIN(14), PSEN1(3) 2426914 34 27 34 11 11 5 5 7 6 0 0.336 1.000 1.000 74 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 ABO(5), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GCNT2(24), ST3GAL6(12), ST8SIA1(10) 6934431 120 82 112 28 40 18 10 34 17 1 0.0354 1.000 1.000 75 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(1), COQ5(2), COQ6(2), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1) 2135214 16 16 18 6 6 1 6 1 2 0 0.570 1.000 1.000 76 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(6), MMP2(12), MMP9(14), RECK(12), TIMP1(1), TIMP2(3), TIMP3(10), TIMP4(4) 3887906 66 50 63 19 33 11 5 11 6 0 0.146 1.000 1.000 77 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), KARS(8) 3769147 42 35 39 11 8 5 6 15 8 0 0.433 1.000 1.000 78 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GGT1(9), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), GSR(5), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTM5(10), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH1(18), IDH2(16), MGST1(2), MGST2(2), MGST3(1), TXNDC12(1) 10504002 182 113 154 39 36 43 28 44 31 0 0.00146 1.000 1.000 79 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(7), CBS(3), CTH(5), GGT1(9), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), PAPSS1(4), PAPSS2(5), SCLY(11), SEPHS1(5) 6284020 79 58 69 20 24 8 12 15 20 0 0.1000 1.000 1.000 80 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(11), ALAS2(10), CPO(9), FECH(3), GATA1(18), HBB(2), HMBS(4), UROD(2), UROS(5) 4302767 64 46 59 16 19 16 7 13 9 0 0.155 1.000 1.000 81 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(10), CARS2(6), CDO1(3), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), SDS(3), SULT1B1(5), SULT1C2(6), SULT1C4(3), SULT4A1(6) 6472072 85 64 78 21 29 16 11 17 12 0 0.0739 1.000 1.000 82 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(5), DPM2(1), EGR1(11), HRAS(4), KLK2(4), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), NGFR(4), RAF1(13) 3848594 62 48 54 20 26 7 9 11 9 0 0.181 1.000 1.000 83 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), AOC2(12), AOC3(9), ASPA(6), CNDP1(7), DDC(5), HAL(11), HARS(6), HDC(8), HNMT(11), MAOA(5), MAOB(6), PRPS1(8), PRPS2(6) 12704245 205 115 181 40 62 44 29 47 23 0 4.74e-05 1.000 1.000 84 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(7), IFNAR1(7), IFNAR2(3), IFNB1(6), JAK1(20), STAT1(15), STAT2(10), TYK2(5) 5559736 73 56 64 19 21 17 6 18 11 0 0.183 1.000 1.000 85 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(7), ACAA2(2), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AKR1C4(10), AKR1D1(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), SOAT2(4), SRD5A1(2), SRD5A2(2) 12059743 201 114 178 40 51 47 30 50 22 1 8.55e-05 1.000 1.000 86 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(11), PON2(6), PON3(10), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 4334998 68 50 62 20 17 17 7 17 10 0 0.272 1.000 1.000 87 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(11), ACOX3(8), FADS2(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8) 5392445 63 46 60 14 22 11 7 14 9 0 0.0417 1.000 1.000 88 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(10), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHB(5), LDHC(4) 3413585 42 38 37 12 14 10 5 7 6 0 0.336 1.000 1.000 89 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(3), CASP7(3), DFFA(4), DFFB(2), ENDOG(3), GZMB(4), HMGB1(2), HMGB2(2), TOP2A(23), TOP2B(24) 4743669 70 55 59 16 10 13 7 20 20 0 0.427 1.000 1.000 90 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(19), CD3D(4), CD3E(2), CD3G(15), GZMB(4), HLA-A(23), ICAM1(4), ITGAL(18), ITGB2(16), PRF1(7) 4119254 112 74 88 32 30 14 6 14 46 2 0.544 1.000 1.000 91 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(6), CAT(7), EPX(13), LPO(9), MPO(13), MTHFR(8), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29) 5802832 100 70 89 26 47 13 10 16 14 0 0.0811 1.000 1.000 92 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), RFK(1), TYR(9) 5145819 67 43 60 15 18 18 8 14 8 1 0.0505 1.000 1.000 93 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), RAC1(2), WASF1(3), WASL(16) 4286018 61 44 58 19 17 7 9 18 10 0 0.398 1.000 1.000 94 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(8), GNAQ(10), ITPKA(3), ITPKB(14) 2758937 40 34 39 14 15 7 3 10 5 0 0.502 1.000 1.000 95 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(11), CLOCK(20), CRY1(13), CRY2(5), CSNK1D(14), CSNK1E(9), NPAS2(10), NR1D1(7), PER1(12), PER2(7), PER3(18) 8609520 126 80 100 27 42 26 9 27 21 1 0.0112 1.000 1.000 96 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(13), EIF2AK4(21), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF5(6), GSK3B(16), PPP1CA(2) 5915668 79 63 68 18 14 28 5 13 19 0 0.0963 1.000 1.000 97 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3) 3758496 51 39 49 13 14 6 5 8 18 0 0.230 1.000 1.000 98 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(11), ACO2(7), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2) 6796112 74 53 68 18 23 9 13 19 10 0 0.0429 1.000 1.000 99 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 C9orf47(2), CNR1(10), CNR2(1), DNMT1(20), MTNR1A(2), MTNR1B(11), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2) 5210537 69 49 62 19 29 9 6 13 12 0 0.0412 1.000 1.000 100 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(8), ANKRD1(7), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(8), IL18(3), IL1A(1), IL1R1(6), MYOG(5), NR4A3(7), WDR1(7) 5529734 59 40 59 15 16 12 8 15 8 0 0.161 1.000 1.000 101 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(13), GBA3(3), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TPO(29), TYR(9) 4802549 86 64 79 23 41 15 7 13 10 0 0.0874 1.000 1.000 102 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(5), SEC61A2(4), SRP19(1), SRP54(2), SRP68(10), SRP72(8), SRPR(11) 3979504 41 34 33 10 9 7 5 9 11 0 0.456 1.000 1.000 103 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(4), GSR(5), GSS(8), IL8(5), NFKB1(8), NOX1(4), RELA(9), TNF(1), XDH(19) 5182619 63 50 59 17 13 20 7 9 14 0 0.236 1.000 1.000 104 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(23), BAD(1), BAK1(2), BAX(14), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), CASP8AP2(27), CASP9(5), CES1(13) 5439431 101 64 83 29 20 8 14 22 35 2 0.756 1.000 1.000 105 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(2), CTSD(6), ESR1(20), GREB1(24), HSPB2(2), MTA1(6), MTA3(3), PDZK1(2), TUBA8(4) 4753786 69 48 69 23 26 7 9 13 14 0 0.349 1.000 1.000 106 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(3), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), MECR(4), PPT1(1), PPT2(4) 4419959 46 40 46 14 12 9 5 11 9 0 0.346 1.000 1.000 107 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(7), CS(2), FH(9), IDH2(16), MDH1(8), OGDH(13), SDHA(12), SUCLA2(6) 4929826 73 61 65 23 22 13 8 16 14 0 0.341 1.000 1.000 108 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), CYCS(1), GPD2(10), NDUFA1(2), SDHA(12), SDHB(3), SDHD(4), UQCRC1(4) 3380932 40 30 40 11 17 2 8 10 3 0 0.304 1.000 1.000 109 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(8), ME1(11), PC(12), PDHA1(7), SLC25A1(1), SLC25A11(2) 4576581 55 49 49 16 17 15 7 9 7 0 0.219 1.000 1.000 110 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(8), ABP1(4), ACADL(4), ACADM(9), ACADSB(7), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), MLYCD(4), SDS(3), SMS(4), UPB1(7) 15047720 262 128 242 61 80 41 40 71 30 0 0.000278 1.000 1.000 111 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(3), CPS1(31), GLS(2), GLUD1(4), GOT1(6) 4073816 48 37 44 13 11 13 10 10 4 0 0.199 1.000 1.000 112 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(3), GRB2(9), HBXIP(4), HRAS(4), PTK2B(13), SHC1(13), SOS1(11), SRC(3) 4492123 60 51 50 17 8 14 8 13 16 1 0.515 1.000 1.000 113 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(6), ATP6V0C(1), CAT(7), EPX(13), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29) 5869137 99 70 88 27 49 13 10 13 14 0 0.0757 1.000 1.000 114 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(4), UBE2A(4), UBE2B(3), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(3), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(19) 5278573 63 44 61 20 17 11 5 13 17 0 0.384 1.000 1.000 115 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), IDI1(4), LSS(4), MVD(3), MVK(16), NQO1(1), NQO2(2), PMVK(2), SC5DL(7), SQLE(1) 5433643 59 45 48 17 17 7 7 13 15 0 0.425 1.000 1.000 116 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(22), GNAS(35), GNB1(3), PRKACA(1), PRKAR1A(3) 2973232 64 56 47 21 36 16 3 6 3 0 0.287 1.000 1.000 117 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(11), ACO2(7), AFMID(2), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2) 7126627 76 53 70 20 23 9 13 21 10 0 0.0708 1.000 1.000 118 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 136 APC(530), AXIN1(8), AXIN2(24), BTRC(7), CACYBP(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(4), CHD8(35), CREBBP(68), CSNK1A1(3), CSNK1A1L(8), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(13), CTNNB1(99), CTNNBIP1(1), CUL1(16), CXXC4(2), DAAM1(8), DAAM2(15), DKK1(8), DKK2(24), DKK4(5), DVL2(11), DVL3(8), EP300(42), FBXW11(12), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LEF1(9), LRP5(11), LRP6(24), MAP3K7(7), MAPK10(14), MAPK8(11), MAPK9(10), MMP7(8), MYC(5), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NKD1(6), NLK(12), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PORCN(3), PPARD(4), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRICKLE1(18), PRICKLE2(14), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PSEN1(3), RAC1(2), RAC2(1), RHOA(12), ROCK1(27), ROCK2(15), RUVBL1(7), SENP2(3), SFRP1(2), SFRP2(8), SFRP4(5), SFRP5(1), SIAH1(2), SKP1(2), SMAD2(17), SMAD3(17), SMAD4(166), TBL1X(8), TBL1XR1(11), TCF7(12), TCF7L1(7), TCF7L2(45), TP53(326), VANGL1(12), VANGL2(9), WIF1(5), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3) 76827568 2305 361 1746 738 529 531 243 414 459 129 0.00430 1.000 1.000 119 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(3), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), APC(530), ARAF(10), ARHGEF1(13), ARHGEF12(10), ARHGEF4(8), ARHGEF6(16), ARHGEF7(21), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(2), BAIAP2(6), BCAR1(5), BDKRB1(3), BDKRB2(4), BRAF(111), CD14(6), CDC42(2), CFL1(2), CFL2(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CRKL(5), CSK(3), CYFIP1(15), CYFIP2(10), DIAPH1(7), DIAPH2(24), DIAPH3(17), DOCK1(22), EGF(7), EGFR(104), EZR(3), F2(9), F2R(11), FGD1(18), FGD3(15), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF3(5), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR3(25), FGFR4(11), FN1(52), GIT1(3), GNA12(6), GNA13(3), GNG12(8), GRLF1(18), GSN(4), HRAS(4), IQGAP1(24), IQGAP2(25), IQGAP3(23), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAV(17), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), KRAS(184), LIMK1(7), LIMK2(11), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MOS(8), MRAS(4), MSN(6), MYH10(15), MYH14(22), MYH9(40), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), NCKAP1(15), NCKAP1L(21), NRAS(34), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PFN2(4), PFN4(6), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PPP1R12B(28), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAF1(13), RDX(13), RHOA(12), ROCK1(27), ROCK2(15), RRAS(2), RRAS2(4), SCIN(10), SLC9A1(9), SOS1(11), SOS2(15), SSH1(13), SSH2(16), SSH3(3), TIAM1(34), TIAM2(24), TMSL3(2), VAV1(22), VAV2(18), VAV3(27), VCL(9), WAS(4), WASF1(3), WASF2(5), WASL(16) 139621825 3284 361 2502 1101 642 790 485 724 516 127 0.0148 1.000 1.000 120 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 241 ACVR1B(28), ACVR1C(9), AKT1(11), AKT2(7), AKT3(7), ARRB1(4), ARRB2(1), ATF2(6), ATF4(2), BDNF(4), BRAF(111), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CACNA2D1(28), CACNA2D2(9), CACNA2D3(21), CACNA2D4(12), CACNB1(6), CACNB2(9), CACNB3(2), CACNB4(3), CACNG1(5), CACNG2(5), CACNG3(8), CACNG4(4), CACNG5(8), CACNG6(3), CACNG7(6), CACNG8(2), CASP3(3), CD14(6), CDC25B(11), CDC42(2), CHUK(23), CRKL(5), DAXX(14), DDIT3(4), DUSP1(6), DUSP10(5), DUSP16(9), DUSP3(4), DUSP4(6), DUSP5(1), DUSP6(6), DUSP7(6), DUSP9(9), ECSIT(6), EGF(7), EGFR(104), ELK1(4), ELK4(4), FAS(7), FASLG(3), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF3(5), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR3(25), FGFR4(11), FLNA(24), FLNB(36), FLNC(36), FOS(4), GADD45G(1), GNA12(6), GNG12(8), GRB2(9), HRAS(4), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), JUN(2), KRAS(184), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAPT(10), MAX(5), MEF2C(15), MKNK1(2), MKNK2(6), MOS(8), MRAS(4), MYC(5), NF1(118), NFATC2(10), NFATC4(11), NFKB1(8), NFKB2(4), NLK(12), NR4A1(3), NRAS(34), NTF3(3), NTRK1(16), NTRK2(23), PAK1(10), PAK2(14), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PPM1A(8), PPM1B(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PPP5C(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTPN5(7), PTPN7(3), PTPRR(11), RAC1(2), RAC2(1), RAF1(13), RAP1A(1), RAP1B(2), RAPGEF2(29), RASA1(20), RASA2(15), RASGRF1(22), RASGRF2(20), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KA6(15), RRAS(2), RRAS2(4), SOS1(11), SOS2(15), SRF(4), STK3(8), STK4(8), STMN1(1), TAOK1(17), TAOK2(13), TAOK3(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF1A(4), TP53(326), TRAF2(8), TRAF6(4), ZAK(8) 140398924 3046 356 2470 940 808 639 448 685 446 20 6.71e-07 1.000 1.000 121 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 190 ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), ARHGAP5(43), BAD(1), BCAR1(5), BCL2(2), BIRC2(5), BIRC3(11), BRAF(111), CAPN2(8), CAV2(4), CAV3(3), CCND1(2), CCND2(3), CCND3(2), CDC42(2), CHAD(9), COL11A1(56), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), CRKL(5), CTNNB1(99), DIAPH1(7), DOCK1(22), EGF(7), EGFR(104), ELK1(4), ERBB2(28), FARP2(12), FIGF(4), FLNA(24), FLNB(36), FLNC(36), FLT1(34), FN1(52), FYN(15), GRB2(9), GRLF1(18), GSK3B(16), HGF(13), HRAS(4), IBSP(6), IGF1(6), IGF1R(17), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAV(17), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), JUN(2), KDR(38), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), MAP2K1(10), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MET(48), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(1), PDGFC(9), PDGFD(11), PDGFRA(56), PDGFRB(20), PDPK1(4), PGF(3), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PRKCA(5), PRKCG(19), PTEN(286), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAF1(13), RAP1A(1), RAP1B(2), RAPGEF1(19), RELN(83), RHOA(12), ROCK1(27), ROCK2(15), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SPP1(4), SRC(3), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TLN1(21), TLN2(13), TNC(38), TNN(30), TNR(45), TNXB(51), VASP(4), VAV1(22), VAV2(18), VAV3(27), VCL(9), VEGFA(5), VEGFB(3), VEGFC(11), VTN(10), VWF(30), ZYX(2) 182148664 3716 343 3120 1430 885 989 507 819 493 23 0.596 1.000 1.000 122 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(11), APC(530), AR(20), ASAH1(4), BRAF(111), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(8), EGFR(104), GNA11(8), GNA15(5), GNAI1(3), GNAQ(10), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), MAPK10(14), MAPK14(7), PHKA2(15), PIK3CA(288), PIK3CD(10), PIK3R1(53), PITX2(2), PTX3(3), RAF1(13), SRC(3) 26669856 1397 343 934 487 174 436 183 269 220 115 0.153 1.000 1.000 123 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(530), AXIN1(8), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), CTNNB1(99), DVL2(11), DVL3(8), FBXW2(5), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LDLR(9), MAPK10(14), MAPK9(10), MYC(5), PAFAH1B1(6), PLAU(6), PPP2R5C(5), PPP2R5E(8), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), RAC1(2), RHOA(12), SFRP4(5), TCF7(12), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4) 27853721 1059 337 773 360 170 278 95 166 234 116 0.204 1.000 1.000 124 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(11), AKT1(11), AKT2(7), AKT3(7), APAF1(23), ATM(200), BAD(1), BAX(14), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CAPN1(2), CAPN2(8), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CHUK(23), CSF2RB(13), CYCS(1), DFFA(4), DFFB(2), ENDOG(3), FADD(1), FAS(7), FASLG(3), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL3(6), IRAK1(6), IRAK2(11), IRAK3(9), IRAK4(6), MAP3K14(6), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), NTRK1(16), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), RIPK1(7), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10C(9), TNFRSF10D(1), TNFRSF1A(4), TNFSF10(2), TP53(326), TRAF2(8) 42379272 1334 335 936 449 264 408 181 255 215 11 0.0787 1.000 1.000 125 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(27), ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), ATM(200), ATR(43), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDC14A(10), CDC14B(5), CDC16(5), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(5), CDC26(1), CDC27(16), CDC6(6), CDC7(23), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CHEK1(10), CHEK2(27), CREBBP(68), CUL1(16), DBF4(8), E2F2(7), E2F3(5), EP300(42), ESPL1(22), FZR1(3), GADD45G(1), GSK3B(16), HDAC1(5), HDAC2(8), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTTG1(2), RB1(123), RBL1(18), RBL2(22), SFN(1), SKP1(2), SKP2(3), SMAD2(17), SMAD3(17), SMAD4(166), SMC1A(21), SMC1B(25), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TP53(326), WEE1(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 70255662 1745 332 1340 556 365 491 184 364 315 26 0.0193 1.000 1.000 126 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(11), APC(530), AXIN1(8), CCND1(2), CD14(6), CTNNB1(99), FZD1(7), GJA1(5), GNAI1(3), GSK3B(16), IRAK1(6), LBP(7), LEF1(9), LY96(4), MYD88(3), NFKB1(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), RELA(9), TIRAP(5), TLR4(15), TOLLIP(5), WNT1(7) 14743955 1113 331 693 379 90 385 148 166 208 116 0.0123 1.000 1.000 127 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 225 ADCYAP1R1(4), ADORA1(14), ADORA2A(4), ADORA2B(5), ADORA3(14), ADRA1A(10), ADRA1B(5), ADRA2A(5), ADRA2B(6), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AGTR2(15), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), C5AR1(7), CALCR(8), CALCRL(7), CCKAR(6), CCKBR(12), CGA(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CNR1(10), CNR2(1), CRHR1(4), CRHR2(5), CTSG(4), CYSLTR1(9), CYSLTR2(16), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2(9), F2R(11), F2RL1(7), F2RL2(6), FPR1(5), FSHB(4), FSHR(16), GABBR1(16), GABBR2(15), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GABRB1(10), GABRB2(7), GABRB3(14), GABRD(6), GABRE(10), GABRG1(17), GABRG2(15), GABRG3(11), GABRP(9), GABRQ(16), GABRR1(5), GABRR2(8), GALR1(4), GH1(4), GH2(4), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(6), GLP2R(8), GLRA1(10), GLRA2(8), GLRA3(12), GLRB(13), GNRHR(9), GPR156(15), GPR35(3), GPR50(9), GPR63(4), GPR83(6), GRIA1(35), GRIA2(23), GRIA3(11), GRIA4(36), GRID1(28), GRID2(25), GRIK1(13), GRIK2(43), GRIK3(28), GRIK4(20), GRIK5(14), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRIN3A(16), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM6(24), GRM7(30), GRM8(27), GRPR(4), GZMA(8), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HRH4(6), HTR1A(15), HTR1B(11), HTR1D(4), HTR1E(15), HTR1F(9), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LEP(1), LEPR(15), LHB(3), LHCGR(27), LTB4R(1), MAS1(2), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), MCHR1(8), MCHR2(21), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPBWR1(5), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(6), NPY2R(12), NPY5R(5), NR3C1(8), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), P2RY1(5), P2RY10(12), P2RY11(5), P2RY13(18), P2RY14(9), P2RY2(6), P2RY4(8), P2RY6(5), PARD3(11), PPYR1(5), PRL(3), PRLHR(5), PRLR(8), PRSS1(6), PRSS3(6), PTAFR(1), PTGDR(7), PTGER2(2), PTGER3(16), PTGER4(4), PTGFR(7), PTGIR(2), PTH2R(14), RXFP1(6), RXFP2(18), SCTR(5), SSTR1(11), SSTR2(4), SSTR4(12), TAAR1(6), TAAR2(6), TAAR5(8), TAAR6(4), TAAR8(5), TAAR9(6), TACR1(9), TACR2(4), TACR3(11), THRA(6), THRB(14), TRHR(7), TRPV1(9), TSHB(1), TSHR(55), TSPO(1), VIPR1(6), VIPR2(11) 107861002 2224 331 2006 793 745 422 257 516 279 5 0.0350 1.000 1.000 128 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 28 AKT1(11), AKT2(7), AKT3(7), ANKRD6(12), APC(530), AXIN1(8), AXIN2(24), CER1(4), CSNK1A1(3), CTNNB1(99), DACT1(18), DKK1(8), DKK2(24), DKK3(7), DKK4(5), FSTL1(9), GSK3A(6), GSK3B(16), LRP1(49), MVP(10), NKD1(6), PIN1(2), PSEN1(3), PTPRA(5), SENP2(3), SFRP1(2), TSHB(1), WIF1(5) 19778956 884 331 613 295 115 235 80 139 197 118 0.254 1.000 1.000 129 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(6), APC(530), ATF2(6), AXIN1(8), BMP10(13), BMP2(8), BMP4(5), BMP5(8), BMP7(14), BMPR1A(18), BMPR2(46), CHRD(14), CTNNB1(99), FZD1(7), GATA4(4), GSK3B(16), MAP3K7(7), MEF2C(15), MYL2(2), NPPA(1), NPPB(4), RFC1(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14), WNT1(7) 17903511 923 330 639 293 114 233 84 159 207 126 0.0387 1.000 1.000 130 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(27), ATM(200), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDAN1(7), CDC14A(10), CDC14B(5), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(5), CDC6(6), CDC7(23), CDH1(87), CDK2(5), CDK4(3), CDKN1A(2), CDKN2A(7), CHEK1(10), CHEK2(27), DTX4(8), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), EP300(42), ESPL1(22), GSK3B(16), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), HDAC8(3), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MPEG1(6), MPL(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTPRA(5), PTTG1(2), RB1(123), RBL1(18), SKP2(3), SMAD4(166), TBC1D8(11), TFDP1(10), TGFB1(2), TP53(326), WEE1(15) 56972158 1573 330 1176 507 305 483 173 313 276 23 0.0132 1.000 1.000 131 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(27), ABL2(17), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), BRAF(111), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CBL(38), CBLB(14), CBLC(3), CDKN1A(2), CDKN1B(4), CRKL(5), EGF(7), EGFR(104), ELK1(4), ERBB2(28), ERBB3(28), ERBB4(56), EREG(3), GAB1(15), GRB2(9), GSK3B(16), HBEGF(1), HRAS(4), JUN(2), KRAS(184), MAP2K1(10), MAP2K2(2), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MYC(5), NCK2(4), NRAS(34), NRG1(26), NRG2(6), NRG3(14), NRG4(2), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), RAF1(13), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SRC(3), STAT5A(8), STAT5B(19) 52062157 1595 326 1102 532 252 453 323 379 186 2 0.0191 1.000 1.000 132 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 166 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY7(10), ADCY8(30), ADCY9(19), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), ATP2A1(23), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), ATP2B4(21), AVPR1A(13), AVPR1B(5), BDKRB1(3), BDKRB2(4), BST1(2), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CCKAR(6), CCKBR(12), CD38(4), CHRM1(4), CHRM2(25), CHRM3(21), CHRM5(5), CYSLTR1(9), CYSLTR2(16), DRD1(9), EDNRA(8), EDNRB(13), EGFR(104), ERBB2(28), ERBB3(28), ERBB4(56), F2R(11), GNA11(8), GNA14(10), GNA15(5), GNAL(4), GNAQ(10), GNAS(35), GRIN1(5), GRIN2A(48), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), GRPR(4), HRH1(4), HRH2(15), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), LHCGR(27), MYLK(29), MYLK2(9), NOS1(23), NOS3(21), NTSR1(5), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), PDE1A(8), PDE1B(10), PDE1C(17), PDGFRA(56), PDGFRB(20), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PPID(4), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTAFR(1), PTGER3(16), PTGFR(7), PTK2B(13), RYR1(58), RYR2(122), RYR3(82), SLC25A4(4), SLC25A5(8), SLC8A1(22), SLC8A2(14), SLC8A3(13), SPHK1(2), SPHK2(5), TACR1(9), TACR2(4), TACR3(11), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(15), VDAC1(6), VDAC2(4), VDAC3(2) 132064956 2444 326 2284 901 842 474 275 516 327 10 0.346 1.000 1.000 133 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 125 ACACA(30), ACACB(37), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), BRAF(111), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBL(38), CBLB(14), CBLC(3), CRKL(5), ELK1(4), EXOC7(3), FBP1(1), FBP2(4), FLOT1(6), FLOT2(2), FOXO1(8), G6PC(4), G6PC2(2), GCK(3), GRB2(9), GSK3B(16), GYS1(5), GYS2(13), HRAS(4), IKBKB(7), INPP5D(8), INSR(20), IRS1(17), IRS4(30), KRAS(184), LIPE(9), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MKNK1(2), MKNK2(6), NRAS(34), PCK1(3), PCK2(6), PDE3A(19), PDE3B(8), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PKLR(11), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R3A(38), PPP1R3B(4), PPP1R3C(4), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCI(24), PRKCZ(3), PRKX(3), PTPN1(10), PTPRF(21), PYGB(15), PYGL(6), PYGM(10), RAF1(13), RAPGEF1(19), RHEB(4), RHOQ(6), RPS6(2), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SLC2A4(7), SOCS2(2), SORBS1(11), SOS1(11), SOS2(15), SREBF1(8), TRIP10(4), TSC1(17), TSC2(15) 77152334 1676 324 1207 544 345 405 320 413 191 2 0.00182 1.000 1.000 134 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(530), AXIN1(8), CREBBP(68), CTNNB1(99), EP300(42), FZD1(7), GSK3B(16), HDAC1(5), LDB1(7), LEF1(9), PITX2(2), TRRAP(61), WNT1(7) 16638155 861 324 590 301 92 251 86 126 190 116 0.173 1.000 1.000 135 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 APAF1(23), ATM(200), ATR(43), BAI1(11), BAX(14), BID(2), CASP3(3), CASP8(19), CASP9(5), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG1(4), CCNG2(4), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN2A(7), CHEK1(10), CHEK2(27), CYCS(1), EI24(1), FAS(7), GADD45G(1), GTSE1(2), IGF1(6), IGFBP3(6), MDM2(11), MDM4(6), PPM1D(6), PTEN(286), RCHY1(4), RFWD2(5), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(3), SERPINE1(8), SESN1(5), SESN2(8), SESN3(7), SFN(1), SIAH1(2), STEAP3(6), THBS1(12), TNFRSF10B(4), TP53(326), TP73(5), TSC2(15), ZMAT3(9) 31796207 1193 323 840 407 200 401 133 227 210 22 0.170 1.000 1.000 136 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRB1(2), CSNK1D(14), DRD1(9), DRD2(7), EGF(7), EGFR(104), GJA1(5), GJD2(4), GNA11(8), GNAI1(3), GNAI2(2), GNAI3(2), GNAQ(10), GNAS(35), GRB2(9), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), HTR2A(19), HTR2B(7), HTR2C(13), ITPR1(41), ITPR2(41), ITPR3(39), KRAS(184), MAP2K1(10), MAP2K2(2), MAP2K5(4), MAP3K2(8), MAPK1(3), MAPK3(3), MAPK7(6), NPR1(16), NPR2(15), NRAS(34), PDGFA(2), PDGFB(1), PDGFC(9), PDGFD(11), PDGFRA(56), PDGFRB(20), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), PRKX(3), RAF1(13), SOS1(11), SOS2(15), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9) 66009572 1404 323 1131 475 389 281 260 340 132 2 0.00568 1.000 1.000 137 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(2), AKT1(11), APC(530), ASAH1(4), CAMP(1), CAV3(3), DAG1(8), DLG4(10), EPHB2(15), GNAI1(3), GNAQ(10), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(4), RYR1(58) 23036985 818 322 601 287 135 182 83 126 176 116 0.354 1.000 1.000 138 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(530), AXIN1(8), BTRC(7), CCND1(2), CREBBP(68), CSNK1A1(3), CSNK1D(14), CSNK2A1(7), CTBP1(5), CTNNB1(99), FZD1(7), GSK3B(16), HDAC1(5), MAP3K7(7), MYC(5), NLK(12), PPARD(4), PPP2CA(3), TLE1(7), WIF1(5), WNT1(7) 14349769 821 322 556 285 72 226 88 131 188 116 0.181 1.000 1.000 139 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(27), ABLIM1(8), ABLIM2(7), ABLIM3(15), ARHGEF12(10), CDC42(2), CDK5(2), CFL1(2), CFL2(2), CXCL12(2), CXCR4(6), DCC(36), DPYSL2(9), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(3), EFNB1(6), EFNB3(9), EPHA1(7), EPHA2(12), EPHA3(61), EPHA4(20), EPHA5(39), EPHA6(25), EPHA7(38), EPHA8(16), EPHB1(33), EPHB2(15), EPHB3(12), EPHB4(11), EPHB6(12), FES(6), FYN(15), GNAI1(3), GNAI2(2), GNAI3(2), GSK3B(16), HRAS(4), ITGB1(12), KRAS(184), L1CAM(14), LIMK1(7), LIMK2(11), LRRC4C(14), MAPK1(3), MAPK3(3), MET(48), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NGEF(17), NRAS(34), NRP1(11), NTN1(4), NTN4(7), NTNG1(14), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLXNA1(20), PLXNA2(21), PLXNA3(22), PLXNB1(20), PLXNB2(26), PLXNB3(22), PLXNC1(18), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RASA1(20), RGS3(22), RHOA(12), RND1(3), ROBO1(30), ROBO2(59), ROBO3(10), ROCK1(27), ROCK2(15), SEMA3A(17), SEMA3B(7), SEMA3C(17), SEMA3D(22), SEMA3E(17), SEMA3F(12), SEMA3G(8), SEMA4A(12), SEMA4B(3), SEMA4C(5), SEMA4D(17), SEMA4F(9), SEMA4G(9), SEMA5A(19), SEMA5B(22), SEMA6A(8), SEMA6B(6), SEMA6C(11), SEMA6D(11), SEMA7A(2), SLIT1(28), SLIT2(29), SLIT3(23), SRGAP1(23), SRGAP2(9), SRGAP3(19), UNC5A(6), UNC5B(8), UNC5C(13), UNC5D(21) 93288030 1820 320 1526 608 508 331 282 422 269 8 0.0355 1.000 1.000 140 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), AMOTL1(15), ASH1L(51), CASK(9), CDC42(2), CDK4(3), CGN(15), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNNB1(99), CTTN(4), EPB41(11), EPB41L1(13), EPB41L2(12), EPB41L3(31), EXOC3(3), EXOC4(19), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), HCLS1(15), HRAS(4), IGSF5(14), INADL(15), JAM2(2), JAM3(9), KRAS(184), LLGL1(6), LLGL2(6), MAGI1(27), MAGI2(25), MAGI3(8), MLLT4(17), MPDZ(23), MPP5(6), MRAS(4), MYH1(38), MYH10(15), MYH11(40), MYH13(26), MYH14(22), MYH15(31), MYH2(37), MYH3(39), MYH4(28), MYH6(27), MYH7(24), MYH7B(27), MYH8(42), MYH9(40), MYL2(2), MYL7(1), NRAS(34), OCLN(2), PARD3(11), PARD6A(1), PARD6B(2), PARD6G(6), PPM1J(3), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP2R3A(14), PPP2R4(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PTEN(286), RAB13(1), RAB3B(3), RHOA(12), RRAS(2), RRAS2(4), SPTAN1(25), SRC(3), SYMPK(11), TJAP1(3), TJP1(21), TJP2(17), TJP3(11), VAPA(2), YES1(9), ZAK(8) 97466198 1989 320 1572 642 500 469 318 438 247 17 0.00306 1.000 1.000 141 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 ARAF(10), BID(2), BRAF(111), CASP3(3), CD244(7), CD247(3), CD48(2), FAS(7), FASLG(3), FCGR3A(4), FCGR3B(2), FYN(15), GRB2(9), GZMB(4), HCST(2), HLA-A(23), HLA-B(19), HLA-C(13), HLA-E(4), HLA-G(12), HRAS(4), ICAM1(4), ICAM2(5), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(9), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), ITGAL(18), ITGB2(16), KIR2DL1(9), KIR2DL3(20), KIR2DL4(5), KIR3DL1(6), KIR3DL2(6), KLRC1(2), KLRC2(2), KLRC3(7), KLRD1(3), KLRK1(7), KRAS(184), LAT(2), LCK(8), LCP2(9), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MICB(1), NCR1(2), NCR2(2), NCR3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NRAS(34), PAK1(10), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRF1(7), PRKCA(5), PRKCG(19), PTK2B(13), PTPN11(31), PTPN6(4), RAC1(2), RAC2(1), RAF1(13), SH2D1A(3), SH2D1B(1), SH3BP2(6), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SYK(5), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10C(9), TNFRSF10D(1), TNFSF10(2), ULBP1(7), ULBP2(2), ULBP3(5), VAV1(22), VAV2(18), VAV3(27), ZAP70(12) 56341783 1514 320 1017 467 257 382 298 375 195 7 0.000521 1.000 1.000 142 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(530), CDH1(87), CREBBP(68), EP300(42), MAP2K1(10), MAP3K7(7), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24) 13709078 805 320 551 266 84 230 80 106 189 116 0.0308 1.000 1.000 143 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(11), AKT2(7), AKT3(7), BCL10(8), CARD11(50), CBL(38), CBLB(14), CBLC(3), CD247(3), CD28(4), CD3D(4), CD3E(2), CD3G(15), CD4(4), CD40LG(10), CD8A(1), CD8B(4), CDC42(2), CDK4(3), CHUK(23), CTLA4(4), FOS(4), FYN(15), GRAP2(3), GRB2(9), HRAS(4), ICOS(2), IFNG(3), IKBKB(7), IKBKG(2), IL10(1), IL2(4), IL4(5), ITK(21), JUN(2), KRAS(184), LAT(2), LCK(8), LCP2(9), MALT1(12), MAP3K14(6), MAP3K8(4), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NRAS(34), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDCD1(2), PDK1(5), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCQ(15), PTPN6(4), PTPRC(27), RASGRP1(7), RHOA(12), SOS1(11), SOS2(15), TEC(8), TNF(1), VAV1(22), VAV2(18), VAV3(27), ZAP70(12) 50802878 1323 319 905 399 228 365 272 288 170 0 5.44e-05 1.000 1.000 144 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(200), CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CREB3(5), CREB3L1(5), CREB3L3(4), CREB3L4(4), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), GBA2(15), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MNAT1(3), MYC(5), MYT1(20), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLE(37), POLE2(5), PRIM1(5), RB1(123), RBL1(18), RPA1(12), RPA2(1), RPA3(4), TFDP1(10), TFDP2(4), TNXB(51), TP53(326), WEE1(15) 36834308 1069 317 811 334 233 287 120 228 182 19 0.00650 1.000 1.000 145 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTB(4), ACTG1(6), CHAD(9), COL11A1(56), COL11A2(17), COL17A1(13), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), DES(5), DSC1(12), DSC2(16), DSC3(12), DSG1(19), DSG2(11), DSG3(17), DSG4(24), FN1(52), GJA1(5), GJA10(12), GJA3(4), GJA4(3), GJA5(7), GJA8(19), GJA9(5), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GJB7(3), GJC1(9), GJC3(3), GJD2(4), GJD4(4), IBSP(6), INA(8), ITGA6(14), ITGB4(16), KRT1(18), KRT10(7), KRT12(6), KRT13(11), KRT14(8), KRT15(8), KRT16(5), KRT17(10), KRT18(3), KRT19(4), KRT2(14), KRT20(2), KRT23(9), KRT24(2), KRT25(12), KRT27(2), KRT28(5), KRT3(10), KRT31(12), KRT32(6), KRT33A(8), KRT33B(5), KRT34(11), KRT35(5), KRT36(5), KRT37(8), KRT38(1), KRT39(9), KRT4(28), KRT40(2), KRT5(7), KRT6A(7), KRT6B(6), KRT6C(6), KRT7(4), KRT71(9), KRT72(14), KRT73(10), KRT74(7), KRT75(13), KRT76(9), KRT77(6), KRT78(5), KRT79(7), KRT8(4), KRT81(2), KRT82(5), KRT83(3), KRT84(8), KRT85(12), KRT86(4), KRT9(12), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), LMNB1(9), LMNB2(2), NES(28), PRPH(2), RELN(83), SPP1(4), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VIM(7), VTN(10), VWF(30) 121072730 1950 317 1815 744 672 291 279 420 284 4 0.578 1.000 1.000 146 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), CREB3(5), CREB3L1(5), CREB3L2(4), CREB3L3(4), CREB3L4(4), CREBBP(68), CTNNB1(99), DCT(17), DVL2(11), DVL3(8), EDN1(3), EDNRB(13), EP300(42), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAS(35), GSK3B(16), HRAS(4), KIT(139), KITLG(3), KRAS(184), LEF1(9), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MC1R(2), MITF(14), NRAS(34), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), POMC(4), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), RAF1(13), TCF7(12), TCF7L1(7), TCF7L2(45), TYR(9), TYRP1(6), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3) 52584786 1346 317 1035 466 363 304 233 296 150 0 0.0315 1.000 1.000 147 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 23 APC(530), ASAH1(4), CAMP(1), CASP3(3), CERK(3), CREB1(3), CREB3(5), CREB5(5), DAG1(8), EPHB2(15), FOS(4), GNAQ(10), ITPKA(3), ITPKB(14), JUN(2), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10) 13029704 696 313 478 223 59 172 67 110 172 116 0.0499 1.000 1.000 148 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 10 ADAM17(11), APC(530), AXIN1(8), BTRC(7), CTNNB1(99), DLL1(6), FZD1(7), GSK3B(16), PSEN1(3), WNT1(7) 8223156 694 312 441 230 38 199 64 108 169 116 0.0477 1.000 1.000 149 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(11), AKT2(7), AKT3(7), BTK(11), FCER1A(5), FYN(15), GAB2(9), GRB2(9), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(8), KRAS(184), LAT(2), LCP2(9), LYN(13), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MS4A2(3), NRAS(34), PDK1(5), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PRKCA(5), PRKCD(15), PRKCE(4), RAC1(2), RAC2(1), RAF1(13), SOS1(11), SOS2(15), SYK(5), TNF(1), VAV1(22), VAV2(18), VAV3(27) 35846769 1077 309 709 323 183 299 249 253 92 1 6.87e-05 1.000 1.000 150 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ATF4(2), CACNA1C(32), CACNA1D(28), CACNA1F(35), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDC42(2), CGA(2), EGFR(104), ELK1(4), FSHB(4), GNA11(8), GNAQ(10), GNAS(35), GNRH1(4), GNRH2(5), GNRHR(9), GRB2(9), HBEGF(1), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), KRAS(184), LHB(3), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK9(10), MMP14(6), MMP2(12), NRAS(34), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLD1(16), PLD2(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(15), PRKX(3), PTK2B(13), RAF1(13), SOS1(11), SOS2(15), SRC(3) 64317708 1304 309 1055 398 345 243 244 325 144 3 0.000123 1.000 1.000 151 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(11), AKT2(7), AKT3(7), BCL10(8), BLNK(1), BTK(11), CARD11(50), CD19(10), CD22(15), CD72(3), CD79A(6), CD79B(2), CHUK(23), CR2(20), FCGR2B(2), FOS(4), GSK3B(16), HRAS(4), IFITM1(2), IKBKB(7), IKBKG(2), INPP5D(8), JUN(2), KRAS(184), LILRB3(6), LYN(13), MALT1(12), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NRAS(34), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RASGRP3(8), SYK(5), VAV1(22), VAV2(18), VAV3(27) 36800422 1067 308 694 313 185 292 241 241 108 0 1.12e-05 1.000 1.000 152 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(10), BRAF(111), C7orf16(11), CACNA1A(27), CRHR1(4), GNA11(8), GNA12(6), GNA13(3), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAS(35), GNAZ(3), GRIA1(35), GRIA2(23), GRIA3(11), GRID2(25), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), IGF1(6), IGF1R(17), ITPR1(41), ITPR2(41), ITPR3(39), KRAS(184), LYN(13), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), NOS1(23), NOS3(21), NPR1(16), NPR2(15), NRAS(34), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), RAF1(13), RYR1(58) 55767791 1245 305 947 414 339 211 226 330 137 2 0.0266 1.000 1.000 153 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(200), ATR(43), BRCA1(29), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(10), CHEK2(27), EP300(42), MDM2(11), MYT1(20), PRKDC(80), RPS6KA1(9), TP53(326), WEE1(15), YWHAH(3), YWHAQ(1) 21809237 856 304 608 285 180 252 92 161 157 14 0.142 1.000 1.000 154 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(22), ADCY8(30), ARAF(10), ATF4(2), BRAF(111), CACNA1C(32), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CREBBP(68), EP300(42), GNAQ(10), GRIA1(35), GRIA2(23), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), KRAS(184), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), NRAS(34), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PPP1R1A(1), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), RAF1(13), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15) 50730283 1177 303 896 411 296 248 207 306 119 1 0.0926 1.000 1.000 155 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(11), AKT2(7), AKT3(7), BAD(1), CASP9(5), CDC42(2), HRAS(4), KDR(38), KRAS(184), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPKAPK2(4), MAPKAPK3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NOS3(21), NRAS(34), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCA(5), PRKCG(19), PTGS2(9), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAF1(13), SH2D2A(4), SHC2(2), SPHK1(2), SPHK2(5), SRC(3), VEGFA(5) 34590786 992 302 631 325 183 254 233 221 101 0 0.00692 1.000 1.000 156 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 83 CD36(3), CD44(5), CD47(8), CHAD(9), COL11A1(56), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), DAG1(8), FN1(52), FNDC1(37), FNDC3A(13), FNDC4(6), FNDC5(2), GP5(8), GP6(11), GP9(1), HMMR(15), HSPG2(26), IBSP(6), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAV(17), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), RELN(83), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SPP1(4), SV2A(22), SV2B(9), SV2C(13), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VTN(10), VWF(30) 108739386 1683 302 1592 668 562 250 236 383 245 7 0.755 1.000 1.000 157 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(200), ATR(43), BRCA1(29), BRCA2(77), CHEK1(10), CHEK2(27), FANCA(9), FANCC(8), FANCD2(35), FANCE(4), FANCF(3), FANCG(5), HUS1(7), MRE11A(15), RAD1(2), RAD17(7), RAD50(23), RAD9A(1), TP53(326), TREX1(3) 23527508 834 300 561 279 152 242 81 157 188 14 0.419 1.000 1.000 158 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(27), ATM(200), ATR(43), CCNA1(16), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), DHFR(1), GSK3B(16), HDAC1(5), RB1(123), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TP53(326) 15692159 823 300 571 265 175 250 77 151 149 21 0.0342 1.000 1.000 159 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 ABL1(27), CDKN2A(7), MDM2(11), MYC(5), PIK3CA(288), PIK3R1(53), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), RAC1(2), RB1(123), TP53(326), TWIST1(3) 9931204 881 299 530 269 158 318 137 142 114 12 0.000210 1.000 1.000 160 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CDK2(5), CDK4(3), CHEK1(10), MYT1(20), RB1(123), TP53(326), WEE1(15), YWHAH(3) 9429664 732 299 488 212 156 231 68 137 122 18 0.00330 1.000 1.000 161 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 55 ALG2(8), BAK1(2), BAX(14), BFAR(8), BTK(11), CAD(20), CASP10(7), CASP3(3), CASP8(19), CASP8AP2(27), CD7(4), CSNK1A1(3), DAXX(14), DEDD(2), DEDD2(1), DFFA(4), DIABLO(3), EGFR(104), EPHB2(15), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(5), MAP2K4(32), MAP3K1(18), MAP3K5(14), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MET(48), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PFN2(4), PTPN13(20), RALBP1(6), RIPK1(7), ROCK1(27), SMPD1(9), TP53(326), TPX2(9), TRAF2(8), TUFM(6) 34868078 909 299 698 266 210 233 109 194 151 12 0.00221 1.000 1.000 162 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(5), ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ACVR1B(28), ACVR1C(9), BAIAP2(6), CDC42(2), CDH1(87), CREBBP(68), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNNB1(99), CTNND1(19), EGFR(104), EP300(42), ERBB2(28), FARP2(12), FER(15), FGFR1(20), FYN(15), IGF1R(17), INSR(20), IQGAP1(24), LEF1(9), LMO7(31), MAP3K7(7), MAPK1(3), MAPK3(3), MET(48), MLLT4(17), NLK(12), PARD3(11), PTPN1(10), PTPN6(4), PTPRB(19), PTPRF(21), PTPRJ(15), PTPRM(38), PVRL1(7), PVRL2(4), PVRL3(4), PVRL4(10), RAC1(2), RAC2(1), RHOA(12), SMAD2(17), SMAD3(17), SMAD4(166), SNAI1(5), SNAI2(10), SORBS1(11), SRC(3), SSX2IP(8), TCF7(12), TCF7L1(7), TCF7L2(45), TGFBR1(17), TGFBR2(24), TJP1(21), VCL(9), WAS(4), WASF1(3), WASF2(5), WASF3(14), WASL(16), YES1(9) 61119659 1481 297 1237 487 330 404 186 311 242 8 0.0162 1.000 1.000 163 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(11), APAF1(23), ATM(200), BAD(1), BAX(14), BCL2(2), BCL2L1(1), BID(2), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CYCS(1), EIF2S1(3), PRKCA(5), PTK2(24), PXN(2), STAT1(15), TLN1(21), TP53(326) 14393124 664 296 453 219 148 186 71 122 125 12 0.203 1.000 1.000 164 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 240 ACVR1(6), ACVR1B(28), ACVR2A(64), ACVR2B(12), AMHR2(4), BMP2(8), BMP7(14), BMPR1A(18), BMPR1B(14), BMPR2(46), CCL11(1), CCL13(1), CCL14(4), CCL15(2), CCL16(2), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL28(4), CCL4(1), CCL7(2), CCL8(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CD27(4), CD40(6), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(4), CSF1R(15), CSF2RB(13), CSF3(2), CSF3R(18), CX3CL1(4), CX3CR1(5), CXCL1(1), CXCL10(1), CXCL11(3), CXCL12(2), CXCL14(1), CXCL16(2), CXCL5(5), CXCL6(1), CXCL9(6), CXCR3(4), CXCR4(6), CXCR6(1), EDA(2), EDA2R(4), EDAR(6), EGF(7), EGFR(104), EPO(1), EPOR(2), FAS(7), FASLG(3), FLT1(34), FLT3(27), FLT3LG(1), FLT4(16), GDF5(11), GH1(4), GH2(4), GHR(12), HGF(13), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(9), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL15(1), IL15RA(1), IL17A(2), IL17B(1), IL17RA(7), IL17RB(8), IL18(3), IL18R1(13), IL18RAP(10), IL19(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL1RAP(5), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL25(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL8(5), IL9(1), INHBA(17), INHBB(3), INHBC(3), INHBE(2), KDR(38), KIT(139), KITLG(3), LEP(1), LEPR(15), LIF(1), LIFR(35), LTA(1), LTBR(4), MET(48), MPL(5), NGFR(4), OSM(4), OSMR(20), PDGFB(1), PDGFC(9), PDGFRA(56), PDGFRB(20), PF4(3), PLEKHO2(7), PPBP(6), PRL(3), PRLR(8), RELT(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10C(9), TNFRSF10D(1), TNFRSF11A(5), TNFRSF11B(5), TNFRSF13B(6), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFRSF8(7), TNFRSF9(9), TNFSF10(2), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(3), TNFSF14(3), TNFSF15(3), TNFSF4(4), TNFSF8(4), TPO(29), TSLP(3), VEGFA(5), VEGFB(3), VEGFC(11), XCL1(1), XCL2(3), XCR1(5) 89188773 1736 296 1504 569 409 417 211 403 277 19 0.0271 1.000 1.000 165 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(23), ATM(200), BAX(14), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDKN1A(2), MDM2(11), PCNA(2), RB1(123), TIMP3(10), TP53(326) 9603978 729 294 478 222 146 226 67 138 133 19 0.0182 1.000 1.000 166 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), AKAP1(7), AKAP10(5), AKAP11(26), AKAP12(30), AKAP2(2), AKAP3(22), AKAP4(14), AKAP5(5), AKAP6(37), AKAP7(20), AKAP8(7), AKAP9(66), ARHGEF1(13), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(6), GNA13(3), GNA14(10), GNA15(5), GNAI2(2), GNAI3(2), GNAL(4), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG12(8), GNG3(1), GNG4(1), GNG7(2), HRAS(4), IL18BP(1), ITPR1(41), KCNJ3(11), KRAS(184), NRAS(34), PALM2(1), PDE1A(8), PDE1B(10), PDE1C(17), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PLCB3(14), PPP3CA(3), PPP3CC(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKD3(15), RHOA(12), RRAS(2), SLC9A1(9), USP5(9) 59607459 1118 293 872 351 265 188 205 277 181 2 0.00420 1.000 1.000 167 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(29), AKT1(11), ATM(200), BAX(14), CDKN1A(2), CPB2(10), CSNK1A1(3), CSNK1D(14), FHL2(2), HIF1A(14), IGFBP3(6), MAPK8(11), MDM2(11), NFKBIB(5), NQO1(1), TP53(326) 10342756 659 293 449 189 141 187 70 128 122 11 0.00986 1.000 1.000 168 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(27), ATM(200), BRCA1(29), CDKN1A(2), CHEK1(10), CHEK2(27), JUN(2), MAPK8(11), MDM2(11), MRE11A(15), NFKB1(8), NFKBIA(1), RAD50(23), RBBP8(14), RELA(9), TP53(326), TP73(5) 15249721 720 292 488 255 150 222 69 128 140 11 0.585 1.000 1.000 169 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(111), CPEB1(7), EGFR(104), ERBB2(28), ERBB4(56), ETS1(6), ETS2(4), ETV6(10), ETV7(3), FMN2(61), GRB2(9), KRAS(184), MAP2K1(10), MAPK1(3), MAPK3(3), NOTCH2(29), NOTCH3(27), NOTCH4(15), PIWIL1(27), PIWIL2(12), PIWIL3(12), PIWIL4(8), RAF1(13), SOS1(11), SOS2(15), SPIRE1(4), SPIRE2(7) 24143734 779 292 503 208 128 172 168 225 86 0 0.000116 1.000 1.000 170 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 144 AKT1(11), AKT2(7), AKT3(7), BCL2L1(1), CBL(38), CBLB(14), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(68), CSF2RB(13), CSF3(2), CSF3R(18), EP300(42), EPO(1), EPOR(2), GH1(4), GH2(4), GHR(12), GRB2(9), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(9), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL13RA2(15), IL15(1), IL15RA(1), IL19(2), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL9(1), IRF9(6), JAK1(20), JAK2(48), JAK3(27), LEP(1), LEPR(15), LIF(1), LIFR(35), MPL(5), MYC(5), OSM(4), OSMR(20), PIAS1(4), PIAS2(4), PIAS3(10), PIAS4(2), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIM1(3), PRL(3), PRLR(8), PTPN11(31), PTPN6(4), SOCS2(2), SOCS5(10), SOCS7(1), SOS1(11), SOS2(15), SPRED1(9), SPRED2(9), SPRY1(9), SPRY2(2), SPRY4(7), STAM(3), STAM2(4), STAT1(15), STAT2(10), STAT3(10), STAT4(10), STAT5A(8), STAT5B(19), STAT6(4), TPO(29), TSLP(3), TYK2(5) 72891522 1429 292 1146 495 295 410 219 320 181 4 0.108 1.000 1.000 171 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(23), BAD(1), BAK1(2), BAX(14), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), BIRC2(5), BIRC3(11), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CHUK(23), CYCS(1), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), GZMB(4), HELLS(12), IKBKB(7), IKBKG(2), IRF1(5), IRF2(10), IRF3(2), IRF4(3), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP2K4(32), MAP3K1(18), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), NFKBIB(5), NFKBIE(4), PLEKHG5(8), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFSF10(2), TP53(326), TP73(5), TRAF1(5), TRAF2(8), TRAF3(10) 28334581 736 290 544 199 183 158 89 142 158 6 0.000994 1.000 1.000 172 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(11), ATF2(6), CDC42(2), DLD(3), DUSP10(5), DUSP4(6), GAB1(15), GCK(3), IL1R1(6), JUN(2), MAP2K4(32), MAP2K5(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK10(14), MAPK7(6), MAPK8(11), MAPK9(10), MYEF2(14), NFATC3(13), NR2C2(11), PAPPA(33), SHC1(13), TP53(326), TRAF6(4), ZAK(8) 25167958 723 290 533 179 193 141 96 143 143 7 3.23e-05 1.000 1.000 173 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(27), ACTN1(9), ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGEF6(16), ARHGEF7(21), BCAR1(5), BRAF(111), CDC42(2), CDKN2A(7), CSE1L(10), DOCK1(22), EPHB2(15), FYN(15), GRB2(9), GRB7(3), GRLF1(18), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB3BP(1), MAP2K4(32), MAP3K11(11), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MRAS(4), MYLK(29), MYLK2(9), P4HB(6), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CA(288), PIK3CB(5), PKLR(11), PLCG1(17), PLCG2(23), PTEN(286), PTK2(24), RAF1(13), RALA(7), RHO(4), ROCK1(27), ROCK2(15), SHC1(13), SOS1(11), SOS2(15), SRC(3), TERF2IP(3), TLN1(21), TLN2(13), VASP(4), WAS(4), ZYX(2) 60981397 1515 289 1137 564 242 483 225 339 210 16 0.598 1.000 1.000 174 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(200), ATR(43), CDC25C(5), CHEK1(10), CHEK2(27), TP53(326), YWHAH(3) 8629341 614 287 394 191 130 184 61 109 117 13 0.127 1.000 1.000 175 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(23), BAK1(2), BAX(14), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), FADD(1), FAS(7), FASLG(3), GZMB(4), IKBKG(2), JUN(2), MAP2K4(32), MAP3K1(18), MAP3K14(6), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), PARP1(16), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(2), TP53(326), TRAF1(5), TRAF2(8) 18835747 601 285 424 158 151 132 75 109 128 6 0.000221 1.000 1.000 176 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(11), BCL2(2), EGFR(104), IGF1R(17), MYC(5), POLR2A(12), PPP2CA(3), PRKCA(5), RB1(123), TEP1(29), TERF1(5), TERT(8), TNKS(10), TP53(326), XRCC5(11) 14455283 671 285 462 206 162 196 78 117 106 12 0.00468 1.000 1.000 177 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(18), ATP1B1(4), ATP1B2(2), ATP1B3(4), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1S(29), CACNB1(6), CACNB3(2), CALM2(1), CALM3(1), CALR(1), CAMK1(7), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CASQ1(4), CASQ2(8), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), GJA1(5), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG12(8), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), ITPR1(41), ITPR2(41), ITPR3(39), KCNB1(19), KCNJ3(11), KCNJ5(10), MIB1(8), NME7(6), PEA15(1), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SLC8A3(13), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1) 93307493 1528 284 1466 567 564 246 172 309 229 8 0.364 1.000 1.000 178 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(68), DAXX(14), HRAS(4), PAX3(23), PML(11), RARA(5), RB1(123), SIRT1(7), SP100(14), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TP53(326) 9457098 601 283 401 178 152 172 62 101 102 12 0.00278 1.000 1.000 179 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(12), ACTA2(3), ACTN2(15), ACTN3(6), ACTN4(7), DES(5), DMD(72), FAM48A(9), MYBPC1(9), MYBPC2(16), MYBPC3(14), MYH3(39), MYH6(27), MYH7(24), MYH8(42), MYL1(35), MYL2(2), MYL3(1), MYL4(3), MYOM1(27), NEB(98), TMOD1(7), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(2), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(7), TPM3(6), TPM4(8), TTN(727), VIM(7) 62882263 1251 283 1107 368 345 253 163 340 131 19 0.000986 1.000 1.000 180 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS1(13), CDS2(9), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5D(8), INPP5E(3), INPPL1(14), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), OCRL(16), PI4KA(24), PI4KB(5), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3C3(25), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PRKCA(5), PRKCG(19), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14) 61920237 1442 281 1117 525 297 474 204 274 184 9 0.526 1.000 1.000 181 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 126 ALCAM(11), CADM1(15), CADM3(13), CD2(7), CD22(15), CD226(4), CD274(4), CD276(6), CD28(4), CD34(7), CD4(4), CD40(6), CD40LG(10), CD58(14), CD6(5), CD80(4), CD86(2), CD8A(1), CD8B(4), CDH1(87), CDH15(2), CDH2(33), CDH3(7), CDH4(19), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CNTN1(26), CNTN2(12), CNTNAP1(14), CNTNAP2(33), CTLA4(4), ESAM(6), F11R(4), GLG1(13), HLA-A(23), HLA-B(19), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA1(25), HLA-DQA2(4), HLA-DQB1(1), HLA-DRA(11), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), HLA-G(12), ICAM1(4), ICAM2(5), ICAM3(3), ICOS(2), ICOSLG(4), ITGA4(14), ITGA6(14), ITGA8(16), ITGA9(9), ITGAL(18), ITGAM(13), ITGAV(17), ITGB1(12), ITGB2(16), ITGB7(7), ITGB8(9), JAM2(2), JAM3(9), L1CAM(14), MAG(9), MPZ(2), MPZL1(7), NCAM1(16), NCAM2(21), NEGR1(4), NEO1(12), NFASC(37), NLGN1(18), NLGN2(4), NLGN3(10), NRCAM(17), NRXN1(41), NRXN2(21), NRXN3(33), OCLN(2), PDCD1(2), PDCD1LG2(2), PECAM1(4), PTPRC(27), PTPRF(21), PTPRM(38), PVR(1), PVRL1(7), PVRL2(4), PVRL3(4), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SELE(11), SELL(5), SELP(13), SELPLG(16), SIGLEC1(17), SPN(4), VCAM1(12), VCAN(60) 72187169 1317 281 1191 470 361 217 154 306 259 20 0.439 1.000 1.000 182 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 106 ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ARHGAP5(43), BCAR1(5), CDC42(2), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNNB1(99), CTNND1(19), CXCL12(2), CXCR4(6), CYBB(4), ESAM(6), EZR(3), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), GRLF1(18), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), ITK(21), JAM2(2), JAM3(9), MAPK12(4), MAPK13(4), MAPK14(7), MLLT4(17), MMP2(12), MMP9(14), MSN(6), MYL2(2), MYL7(1), NCF1(4), NCF2(8), NCF4(4), NOX1(4), NOX3(11), OCLN(2), PECAM1(4), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(12), RASSF5(6), RHOA(12), RHOH(4), ROCK1(27), ROCK2(15), SIPA1(9), TXK(10), VASP(4), VAV1(22), VAV2(18), VAV3(27), VCAM1(12), VCL(9) 61632899 1362 280 1076 491 307 387 181 283 199 5 0.506 1.000 1.000 183 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2L1(1), CDC42(2), CDK2(5), CDKN1B(4), CDKN2A(7), CREB1(3), CREB3(5), CREB5(5), EBP(5), ERBB4(56), F2RL2(6), GAB1(15), GRB2(9), GSK3A(6), GSK3B(16), IFI27(15), IGF1(6), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), MET(48), MYC(5), NOLC1(8), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARD3(11), PARD6A(1), PDK1(5), PIK3CA(288), PIK3CD(10), PPP1R13B(9), PREX1(22), PTEN(286), PTK2(24), PTPN1(10), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SLC2A4(7), SOS1(11), SOS2(15), TSC1(17), TSC2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 37540995 1201 276 868 444 176 439 191 225 161 9 0.480 1.000 1.000 184 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(12), ACTA2(3), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADM(5), ARRB1(4), ARRB2(1), ATF1(5), ATF2(6), ATF3(1), ATF4(2), ATF5(2), ATP2A2(16), ATP2A3(11), CACNB3(2), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CNN1(4), CNN2(3), CORIN(18), CREB3(5), CRHR1(4), DGKZ(8), ETS2(4), FOS(4), GABPA(13), GABPB2(3), GBA2(15), GJA1(5), GNAQ(10), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG12(8), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), GSTO1(1), GUCA2B(3), GUCY1A3(25), IGFBP1(2), IGFBP2(3), IGFBP3(6), IGFBP4(4), IGFBP6(2), IL1B(4), IL6(5), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), MIB1(8), MYL2(2), MYL4(3), MYLK2(9), NFKB1(8), NOS1(23), NOS3(21), OXTR(2), PDE4B(9), PDE4D(7), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PLCD1(9), PLCG1(17), PLCG2(23), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RAMP1(2), RAMP2(2), RAMP3(6), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RLN1(3), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SP1(6), TNXB(51), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1) 83448340 1366 275 1313 473 471 216 171 291 211 6 0.0880 1.000 1.000 185 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(6), ACVR1B(28), ACVRL1(7), AKT1(11), AURKB(6), BMPR1A(18), BMPR2(46), BUB1(13), CDKL1(3), CDKL2(16), CDS1(13), CDS2(9), CLK1(8), CLK2(3), CLK4(17), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MAP3K10(10), MOS(8), NEK1(20), NEK3(9), OCRL(16), PAK4(6), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CA(288), PIK3CB(5), PIK3CG(36), PIM2(1), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23), PLK3(3), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKG1(12), RAF1(13), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KB1(9), STK11(36), TGFBR1(17), VRK1(6) 56871116 1228 273 960 408 302 319 189 235 169 14 0.0834 1.000 1.000 186 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 154 ADORA1(14), ADORA2A(4), ADORA2B(5), ADORA3(14), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AGTR2(15), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCBP2(9), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CCRL1(4), CCRL2(5), CHML(21), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CMKLR1(5), CNR1(10), CNR2(1), CX3CR1(5), CXCR3(4), CXCR4(6), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2R(11), F2RL1(7), F2RL2(6), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GPR17(2), GPR173(3), GPR174(8), GPR3(3), GPR35(3), GPR37(12), GPR37L1(8), GPR4(6), GPR44(2), GPR50(9), GPR6(7), GPR63(4), GPR77(3), GPR83(6), GPR85(6), GPR87(11), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HTR1A(15), HTR1B(11), HTR1D(4), HTR1E(15), HTR1F(9), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LHCGR(27), LTB4R(1), MAS1(2), MC1R(2), MC3R(13), MC4R(6), MC5R(7), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPN1SW(8), OPN3(6), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OR10A5(3), OR12D3(1), OR1C1(9), OR1F1(4), OR1Q1(4), OR2H1(3), OR5V1(14), OR7A5(4), OR7C1(13), OR8B8(5), OXTR(2), P2RY1(5), P2RY10(12), P2RY11(5), P2RY12(5), P2RY13(18), P2RY14(9), P2RY2(6), P2RY6(5), PPYR1(5), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), RGR(3), RHO(4), RRH(5), SSTR1(11), SSTR2(4), SSTR4(12), SUCNR1(3), TRHR(7) 57588760 1105 270 988 410 393 223 144 222 122 1 0.0283 1.000 1.000 187 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(6), IFNG(3), IFNGR1(6), IFNGR2(4), IKBKB(7), JAK2(48), LIN7A(7), NFKB1(8), NFKBIA(1), RB1(123), RELA(9), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TP53(326), USH1C(11), WT1(28) 9288951 593 270 387 171 135 187 59 104 93 15 0.00182 1.000 1.000 188 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGAP1(3), ARHGAP4(7), ARHGEF11(20), BTK(11), CDC42(2), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(14), ITPR1(41), ITPR2(41), ITPR3(39), LIMK1(7), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3CG(36), PIK3R1(53), PITX2(2), PPP1R13B(9), PTEN(286), RACGAP1(5), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), SAG(5), WASF1(3), WASL(16) 35039117 1109 269 809 417 164 405 169 219 140 12 0.694 1.000 1.000 189 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(11), AKT2(7), AKT3(7), CASP8(19), CCL4(1), CD14(6), CD40(6), CD80(4), CD86(2), CHUK(23), CXCL10(1), CXCL11(3), CXCL9(6), FADD(1), FOS(4), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(9), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IKBKB(7), IKBKE(8), IKBKG(2), IL12A(1), IL12B(1), IL1B(4), IL6(5), IL8(5), IRAK1(6), IRAK4(6), IRF3(2), IRF5(6), JUN(2), LBP(7), LY96(4), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K7(7), MAP3K8(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), RAC1(2), RELA(9), RIPK1(7), SPP1(4), STAT1(15), TBK1(11), TICAM1(15), TIRAP(5), TLR1(8), TLR2(7), TLR3(13), TLR4(15), TLR5(7), TLR6(12), TLR7(15), TLR8(11), TLR9(12), TNF(1), TOLLIP(5), TRAF3(10), TRAF6(4) 44654509 966 264 767 322 179 277 154 213 141 2 0.0936 1.000 1.000 190 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 39 AKT1(11), ASAH1(4), ATF1(5), BRAF(111), CAMP(1), CREB1(3), CREB3(5), CREB5(5), CREBBP(68), CRKL(5), DAG1(8), EGR1(11), EGR2(14), EGR3(6), EGR4(3), ELK1(4), FRS2(4), GNAQ(10), JUN(2), MAP1B(38), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), NTRK1(16), OPN1LW(3), PIK3C2G(19), PIK3CA(288), PIK3CD(10), PIK3R1(53), PTPN11(31), RPS6KA3(13), SHC1(13), SRC(3), TERF2IP(3) 24336430 859 264 596 339 121 288 146 193 107 4 0.768 1.000 1.000 191 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(14), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), MINPP1(4), MIOX(3), OCRL(16), PI4KA(24), PI4KB(5), PIK3C3(25), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14) 36740407 1053 261 768 388 197 383 160 193 111 9 0.477 1.000 1.000 192 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(11), AKT2(7), AKT3(7), BRD4(21), CAP1(4), CBL(38), CDC42(2), CDKN2A(7), F2RL2(6), FLOT1(6), FLOT2(2), GRB2(9), GSK3A(6), GSK3B(16), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), LNPEP(21), MAPK1(3), MAPK3(3), PARD3(11), PARD6A(1), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3R1(53), PPYR1(5), PTEN(286), PTPN1(10), RAF1(13), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SERPINB6(2), SFN(1), SHC1(13), SLC2A4(7), SORBS1(11), SOS1(11), SOS2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 29071866 1043 261 726 357 158 411 161 186 118 9 0.0342 1.000 1.000 193 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(11), AKT2(7), AKT3(7), BCR(11), BTK(11), CD19(10), CDKN2A(7), DAPP1(3), FLOT1(6), FLOT2(2), GAB1(15), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), PDK1(5), PHF11(3), PIK3CA(288), PITX2(2), PLCG2(23), PPP1R13B(9), PREX1(22), PTEN(286), PTPRC(27), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SAG(5), SYK(5), TEC(8), VAV1(22) 27714304 982 260 715 361 161 378 166 173 96 8 0.397 1.000 1.000 194 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(6), ACVR1B(28), ACVR1C(9), ACVR2A(64), ACVR2B(12), ACVRL1(7), AMHR2(4), BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BMPR1A(18), BMPR1B(14), BMPR2(46), CHRD(14), COMP(6), CREBBP(68), CUL1(16), DCN(7), E2F4(2), E2F5(6), EP300(42), FST(4), GDF5(11), GDF6(6), ID1(2), ID4(1), IFNG(3), INHBA(17), INHBB(3), INHBC(3), INHBE(2), LEFTY1(2), LEFTY2(1), LTBP1(20), MAPK1(3), MAPK3(3), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), RBL1(18), RBL2(22), RHOA(12), ROCK1(27), ROCK2(15), RPS6KB1(9), RPS6KB2(4), SKP1(2), SMAD1(10), SMAD2(17), SMAD3(17), SMAD4(166), SMAD5(3), SMAD7(1), SMAD9(5), SMURF1(7), SMURF2(6), SP1(6), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNF(1), ZFYVE16(20), ZFYVE9(18) 50099087 1049 259 872 345 278 205 120 205 218 23 0.283 1.000 1.000 195 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(12), CRKL(5), DOCK1(22), ELK1(4), FOS(4), GAB1(15), GRB2(9), HGF(13), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K1(10), MAP2K2(2), MAP4K1(6), MAPK1(3), MAPK3(3), MAPK8(11), MET(48), PAK1(10), PIK3CA(288), PIK3R1(53), PTEN(286), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAF1(13), RAP1A(1), RAP1B(2), RASA1(20), SOS1(11), SRC(3), STAT3(10) 23116493 964 257 652 370 106 431 149 175 95 8 0.430 1.000 1.000 196 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(13), CREBBP(68), DUSP1(6), EHHADH(13), EP300(42), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(3), ME1(11), MRPL11(1), MYC(5), NCOA1(13), NCOR1(30), NCOR2(38), NFKBIA(1), NR1H3(16), NR2F1(5), NRIP1(17), PDGFA(2), PIK3CA(288), PIK3R1(53), PPARA(7), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PTGS2(9), RB1(123), RELA(9), RXRA(8), SP1(6), SRA1(2), STAT5A(8), STAT5B(19), TNF(1) 31649689 896 253 638 320 144 304 130 164 146 8 0.321 1.000 1.000 197 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(11), AKT2(7), AKT3(7), BRAF(111), CAB39(2), EIF4B(4), FIGF(4), HIF1A(14), IGF1(6), MAPK1(3), MAPK3(3), PDPK1(4), PGF(3), PIK3CA(288), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R1(53), PIK3R2(3), PIK3R3(3), PIK3R5(5), PRKAA1(8), PRKAA2(15), RHEB(4), RICTOR(24), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), STK11(36), TSC1(17), TSC2(15), ULK2(14), ULK3(3), VEGFA(5), VEGFB(3), VEGFC(11) 25276914 811 252 558 290 135 273 128 179 94 2 0.266 1.000 1.000 198 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), BCR(11), BLNK(1), BTK(11), CD19(10), CD22(15), CR2(20), CSK(3), DAG1(8), FLOT1(6), FLOT2(2), GRB2(9), GSK3A(6), GSK3B(16), INPP5D(8), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP4K1(6), MAPK1(3), MAPK3(3), NFATC2(10), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3R1(53), PLCG2(23), PPP1R13B(9), PPP3CA(3), PPP3CB(10), PPP3CC(5), PTPRC(27), RAF1(13), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22) 35931441 822 249 629 268 180 257 142 145 97 1 0.0157 1.000 1.000 199 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(11), EIF4A2(10), EIF4G1(17), EIF4G2(16), EIF4G3(16), GHR(12), IRS1(17), MAPK1(3), MAPK14(7), MAPK3(3), MKNK1(2), PABPC1(8), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PRKCA(5), PTEN(286), RPS6KB1(9) 14448221 775 246 492 292 74 353 129 133 78 8 0.318 1.000 1.000 200 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(11), AKT2(7), AKT3(7), BAD(1), BTK(11), CDKN2A(7), DAPP1(3), GRB2(9), GSK3A(6), GSK3B(16), IARS(9), IGFBP1(2), INPP5D(8), PDK1(5), PIK3CA(288), PPP1R13B(9), PTEN(286), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SOS1(11), SOS2(15), TEC(8), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 18320288 806 244 537 297 96 352 127 140 82 9 0.207 1.000 1.000 201 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADK(7), ADSL(13), ADSS(5), ADSSL1(6), AK1(1), AK5(7), AK7(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), FHIT(1), GART(5), GDA(6), GMPR(8), GMPR2(3), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NPR1(16), NPR2(15), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE10A(12), PDE11A(13), PDE1A(8), PDE1C(17), PDE2A(10), PDE3B(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6D(2), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PPAT(5), PRIM1(5), PRIM2(2), PRPS1(8), PRPS1L1(3), PRPS2(6), PRUNE(3), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), XDH(19) 84224133 1080 243 1025 378 310 182 169 244 174 1 0.277 1.000 1.000 202 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(11), EIF4A2(10), EIF4B(4), EIF4G1(17), EIF4G2(16), EIF4G3(16), FKBP1A(1), MKNK1(2), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9), TSC1(17), TSC2(15) 13829440 762 242 481 290 76 357 118 121 82 8 0.299 1.000 1.000 203 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM2(1), CALM3(1), CD3D(4), CD3E(2), CD3G(15), ELK1(4), FOS(4), FYN(15), GRB2(9), HRAS(4), JUN(2), LAT(2), LCK(8), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PIK3CA(288), PIK3R1(53), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), PTPN7(3), RAC1(2), RAF1(13), RASA1(20), RELA(9), SHC1(13), SOS1(11), SYT1(14), VAV1(22), ZAP70(12) 23866155 688 241 474 233 131 237 112 103 103 2 0.0691 1.000 1.000 204 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(11), CALM2(1), CALM3(1), ELK1(4), FCER1A(5), FOS(4), GRB2(9), HRAS(4), JUN(2), LYN(13), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PAK2(14), PIK3CA(288), PIK3R1(53), PLA2G4A(13), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), RAF1(13), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22) 21191001 646 240 450 210 111 234 115 109 75 2 0.0153 1.000 1.000 205 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(11), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), GSK3B(16), IGF1(6), IGF1R(17), INPPL1(14), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9) 10227367 738 239 460 286 70 358 116 114 72 8 0.482 1.000 1.000 206 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), EGF(7), EGFR(104), ELK1(4), FOS(4), GRB2(9), HRAS(4), JAK1(20), JUN(2), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8) 19546751 692 238 486 246 113 256 121 124 76 2 0.198 1.000 1.000 207 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCR(11), BLNK(1), BTK(11), CD19(10), CSK(3), DAG1(8), EPHB2(15), GRB2(9), ITPKA(3), ITPKB(14), LYN(13), MAP2K1(10), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PI3(2), PIK3CA(288), PIK3CD(10), PIK3R1(53), PLCG2(23), PPP1R13B(9), RAF1(13), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22) 25601947 636 238 447 207 133 218 115 107 62 1 0.0134 1.000 1.000 208 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(11), BCAR1(5), CDKN1B(4), GRB2(9), ILK(3), ITGB1(12), MAPK1(3), MAPK3(3), PDK2(8), PDPK1(4), PIK3CA(288), PIK3R1(53), PTEN(286), PTK2(24), SHC1(13), SOS1(11) 9660530 737 237 452 277 56 357 117 121 77 9 0.291 1.000 1.000 209 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(2), CDK5R1(5), CFL1(2), CHN1(5), LIMK1(7), MAP3K1(18), MYL2(2), MYLK(29), NCF2(8), PAK1(10), PDGFRA(56), PIK3CA(288), PIK3R1(53), PLD1(16), PPP1R12B(28), RAC1(2), RALBP1(6), RPS6KB1(9), TRIO(38), VAV1(22), WASF1(3) 18187178 611 236 416 216 91 226 107 105 78 4 0.228 1.000 1.000 210 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(11), AKT2(7), AKT3(7), BPNT1(9), GRB2(9), ILK(3), MAPK1(3), MAPK3(3), PDK1(5), PIK3CA(288), PIK3CD(10), PTEN(286), PTK2B(13), RBL2(22), SHC1(13), SOS1(11) 10305903 700 236 432 264 60 328 117 123 63 9 0.488 1.000 1.000 211 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(12), AGT(10), AKT1(11), CALM2(1), CALM3(1), CALR(1), CAMK1(7), CAMK1G(5), CAMK4(6), CREBBP(68), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(9), FGF2(5), FKBP1A(1), GATA4(4), GSK3B(16), HAND1(4), HAND2(1), HRAS(4), IGF1(6), LIF(1), MAP2K1(10), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MEF2C(15), MYH2(37), NFATC2(10), NFATC3(13), NFATC4(11), NPPA(1), PIK3CA(288), PIK3R1(53), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RAF1(13), RPS6KB1(9), SYT1(14) 24877898 722 235 531 265 146 245 117 129 84 1 0.255 1.000 1.000 212 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(8), EIF1(2), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), ELAVL1(5), FLT1(34), FLT4(16), HIF1A(14), HRAS(4), KDR(38), NOS3(21), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), PTK2(24), PXN(2), SHC1(13), VHL(83) 16757573 667 232 443 261 84 272 117 111 82 1 0.669 1.000 1.000 213 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), JAK1(20), JUN(2), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), PDGFA(2), PDGFRA(56), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8) 18171110 639 231 439 220 101 232 112 114 76 4 0.138 1.000 1.000 214 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(11), AKT3(7), BCAR1(5), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(8), CAPN3(10), CAPN5(11), CAPN6(13), CAPN7(11), CAPN9(5), CAPNS1(4), CAV2(4), CAV3(3), CDC42(2), CSK(3), DOCK1(22), FYN(15), GIT2(10), GRB2(9), ILK(3), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAV(17), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAPK10(14), MAPK12(4), MAPK4(4), MAPK6(18), MAPK7(6), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAP1B(2), RAPGEF1(19), RHO(4), ROCK1(27), ROCK2(15), SDCCAG8(2), SEPP1(3), SHC1(13), SHC3(5), SORBS1(11), SOS1(11), SRC(3), TLN1(21), TNS1(34), VASP(4), VAV2(18), VAV3(27), VCL(9), ZYX(2) 67491337 907 230 840 335 265 145 101 224 163 9 0.760 1.000 1.000 215 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(6), GORASP1(11), IKBKG(2), MAP2K4(32), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PIK3CA(288), PIK3CD(10), PIK3R1(53), SYT1(14), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4) 14642055 549 229 364 188 86 212 99 97 54 1 0.103 1.000 1.000 216 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), GRB2(9), GSK3A(6), GSK3B(16), IL4R(6), IRS1(17), JAK1(20), JAK3(27), MAP4K1(6), MAPK1(3), MAPK3(3), PDK1(5), PIK3CA(288), PIK3CD(10), PIK3R1(53), PPP1R13B(9), RAF1(13), SHC1(13), SOS1(11), SOS2(15), STAT6(4) 17627868 562 229 366 185 92 217 98 88 66 1 0.0578 1.000 1.000 217 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), DAG1(8), DGKA(8), ETFA(4), GCA(1), ITGA9(9), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K1(10), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(10), PDE3A(19), PDE3B(8), PI3(2), PIK3C2G(19), PIK3CA(288), PIK3CD(10), PIK3R1(53), PLDN(1), PSME1(1), RIPK3(5), RPS4X(1), SGCB(3), VASP(4) 24181027 640 229 469 235 117 215 112 121 74 1 0.359 1.000 1.000 218 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(51), ASH2L(6), C17orf79(1), CARM1(3), CTCFL(18), DOT1L(9), EED(2), EHMT1(9), EHMT2(7), EZH1(8), EZH2(49), FBXO11(14), HCFC1(11), HSF4(4), JMJD4(1), JMJD6(8), KDM6A(26), MEN1(26), MLL(50), MLL2(59), MLL3(75), MLL4(36), MLL5(26), NSD1(25), OGT(8), PAXIP1(17), PPP1CA(2), PPP1CB(5), PPP1CC(1), PRDM2(34), PRDM7(5), PRDM9(33), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), RBBP5(4), SATB1(16), SETD1A(20), SETD2(47), SETD7(7), SETD8(6), SETDB1(18), SETDB2(4), SETMAR(3), SMYD3(4), STK38(7), SUV39H1(4), SUV39H2(6), SUV420H1(13), SUV420H2(1), SUZ12(4), WHSC1(25), WHSC1L1(10) 59429634 856 228 755 275 222 194 76 187 166 11 0.356 1.000 1.000 219 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(43), DIAPH1(7), FYN(15), GSN(4), HRAS(4), ITGA1(12), ITGB1(12), MAP2K1(10), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PIK3CA(288), PIK3R1(53), PTK2(24), PXN(2), RAF1(13), ROCK1(27), SHC1(13), SRC(3), TLN1(21) 19773053 588 228 372 197 85 217 108 89 83 6 0.0621 1.000 1.000 220 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(22), AKT1(11), BAD(1), BAX(14), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(17), IL3(6), KIT(139), KITLG(3), PIK3CA(288), PIK3R1(53), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), YWHAH(3) 10827843 604 227 392 228 85 275 99 87 57 1 0.475 1.000 1.000 221 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MIOX(3), OCRL(16), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CA(288), PIK3CB(5), PIK3CG(36), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23) 22475976 589 227 415 216 120 191 112 111 54 1 0.420 1.000 1.000 222 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(6), BRAF(111), CHUK(23), CREB1(3), DAXX(14), ELK1(4), FOS(4), GRB2(9), HRAS(4), IKBKB(7), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP3K9(9), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAP4K5(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK4(4), MAPK6(18), MAPK7(6), MAPK8(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MKNK2(6), MYC(5), NFKB1(8), NFKBIA(1), PAK1(10), PAK2(14), RAC1(2), RAF1(13), RELA(9), RIPK1(7), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KB1(9), RPS6KB2(4), SHC1(13), SP1(6), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8) 47305326 828 227 694 239 208 176 111 197 133 3 0.00799 1.000 1.000 223 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(22), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), GNAS(35), GRB2(9), HRAS(4), MAPK1(3), MAPK14(7), MAPK3(3), PIK3CA(288), PIK3R1(53), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RAC1(2), RPS6KA1(9), RPS6KA5(10), SOS1(11) 14713827 526 226 341 187 96 211 93 80 46 0 0.153 1.000 1.000 224 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(11), BCL2(2), BCR(11), CRKL(5), FOS(4), GRB2(9), HRAS(4), JAK2(48), JUN(2), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK3(3), MAPK8(11), MYC(5), PIK3CA(288), PIK3R1(53), RAF1(13), SOS1(11), STAT1(15), STAT5A(8), STAT5B(19) 13998178 582 226 386 198 87 231 107 95 59 3 0.0530 1.000 1.000 225 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(16), CD14(6), CD19(10), CD1A(4), CD1B(5), CD1C(3), CD1D(5), CD1E(16), CD2(7), CD22(15), CD33(2), CD34(7), CD36(3), CD37(4), CD38(4), CD3D(4), CD3E(2), CD3G(15), CD4(4), CD44(5), CD5(7), CD55(7), CD7(4), CD8A(1), CD8B(4), CD9(3), CR1(19), CR2(20), CSF1(4), CSF1R(15), CSF3(2), CSF3R(18), DNTT(11), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(27), FLT3LG(1), GP5(8), GP9(1), GYPA(8), HLA-DRA(11), HLA-DRB1(6), HLA-DRB5(2), IL11(6), IL11RA(4), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL2RA(3), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL7(3), IL7R(12), ITGA1(12), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGAM(13), ITGB3(12), KIT(139), KITLG(3), MME(23), MS4A1(7), TFRC(5), THPO(5), TNF(1), TPO(29) 41173607 733 226 653 258 184 180 102 167 95 5 0.170 1.000 1.000 226 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(68), EP300(42), FYN(15), IL2RG(8), IL7(3), IL7R(12), JAK1(20), JAK3(27), LCK(8), NMI(3), PIK3CA(288), PIK3R1(53), PTK2B(13), STAT5A(8), STAT5B(19) 14495252 589 226 391 216 86 232 99 95 77 0 0.423 1.000 1.000 227 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 27 AKT1(11), CABIN1(22), CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), HDAC5(13), IGF1(6), IGF1R(17), INSR(20), MAP2K6(4), MAPK14(7), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NFATC2(10), PIK3CA(288), PIK3R1(53), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYT1(14), YWHAH(3) 16301590 529 225 355 205 90 206 95 88 50 0 0.499 1.000 1.000 228 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(11), AKT2(7), AKT3(7), CISH(2), GRB2(9), IARS(9), IL13RA1(5), IL2RG(8), IL4(5), IL4R(6), INPP5D(8), JAK1(20), JAK2(48), JAK3(27), PI3(2), PIK3CA(288), PPP1R13B(9), RPS6KB1(9), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT6(4), TYK2(5) 18606319 536 225 357 196 79 208 97 93 56 3 0.365 1.000 1.000 229 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(22), AKT1(11), ASAH1(4), GNAI1(3), GNB1(3), ITGAV(17), ITGB3(12), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(56), PIK3CA(288), PIK3R1(53), PLCB1(22), PRKCA(5), PTK2(24), RAC1(2), SMPD1(9), SMPD2(3), SPHK1(2), SRC(3) 14163896 547 224 360 209 78 220 103 95 47 4 0.390 1.000 1.000 230 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(11), CREB1(3), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NFKB1(8), PIK3CA(288), PIK3R1(53), RB1(123), RELA(9), SP1(6) 10207139 556 224 347 190 70 233 96 95 54 8 0.0361 1.000 1.000 231 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(39), ABCA10(31), ABCA12(66), ABCA13(70), ABCA3(22), ABCA4(31), ABCA5(33), ABCA6(28), ABCA7(21), ABCA8(23), ABCA9(32), ABCB1(29), ABCB10(10), ABCB11(19), ABCB4(23), ABCB5(24), ABCB6(7), ABCB7(6), ABCB8(8), ABCB9(5), ABCC1(20), ABCC10(18), ABCC11(14), ABCC12(22), ABCC2(18), ABCC3(10), ABCC4(24), ABCC5(20), ABCC6(9), ABCC8(21), ABCC9(22), ABCD1(5), ABCD2(18), ABCD3(5), ABCD4(10), ABCG1(7), ABCG2(12), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(16), TAP1(7), TAP2(15) 57548332 848 223 825 259 221 133 99 240 145 10 0.0122 1.000 1.000 232 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 107 ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADK(7), ADSL(13), ADSS(5), AK1(1), AK5(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), ATP1B1(4), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), FHIT(1), GART(5), GDA(6), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NPR1(16), NPR2(15), NT5C(1), NT5E(6), NT5M(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE1A(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6B(11), PDE6C(10), PDE7B(4), PDE8A(6), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), PPAT(5), PRPS1(8), PRPS1L1(3), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5) 64966444 853 223 804 289 250 139 121 205 137 1 0.297 1.000 1.000 233 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(4), GHR(12), GRB2(9), HRAS(4), INSR(20), IRS1(17), JAK2(48), MAP2K1(10), MAPK1(3), MAPK3(3), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), PTPN6(4), RAF1(13), RPS6KA1(9), SHC1(13), SLC2A4(7), SOS1(11), SRF(4), STAT5A(8), STAT5B(19) 16773077 581 222 378 223 89 230 106 93 60 3 0.659 1.000 1.000 234 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CBL(38), CFLAR(2), CRKL(5), FOS(4), GRB2(9), HRAS(4), IL2RA(3), IL2RB(4), IL2RG(8), IRS1(17), JAK1(20), JAK3(27), MAPK1(3), MAPK3(3), MYC(5), NMI(3), PIK3CA(288), PIK3R1(53), PPIA(1), PTPN6(4), RAF1(13), RPS6KB1(9), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19), SYK(5) 17775414 594 222 387 201 88 217 113 94 81 1 0.151 1.000 1.000 235 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), HRAS(4), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(10), PIK3CA(288), PIK3R1(53), RAC1(2), RAF1(13), RB1(123), RELA(9), TFDP1(10) 10421504 563 220 346 203 70 237 98 93 57 8 0.160 1.000 1.000 236 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(8), ADAM17(11), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CDC42(2), CHUK(23), CSK(3), CXCL1(1), EGFR(104), F11R(4), GIT1(3), HBEGF(1), IGSF5(14), IKBKB(7), IKBKG(2), IL8(5), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP2K4(32), MAP3K14(6), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK8(11), MAPK9(10), MET(48), NFKB1(8), NFKB2(4), NFKBIA(1), NOD1(9), PAK1(10), PLCG1(17), PLCG2(23), PTPN11(31), PTPRZ1(37), RAC1(2), RELA(9), SRC(3), TCIRG1(6), TJP1(21) 36224722 641 218 558 217 144 198 85 133 80 1 0.139 1.000 1.000 237 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), INSR(20), IRS1(17), JUN(2), MAP2K1(10), MAPK3(3), MAPK8(11), PIK3CA(288), PIK3R1(53), PTPN11(31), RAF1(13), RASA1(20), SHC1(13), SLC2A4(7), SOS1(11), SRF(4) 12839363 531 217 336 188 78 212 101 85 54 1 0.114 1.000 1.000 238 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(22), ARHGEF1(13), F2(9), F2R(11), GNA12(6), GNA13(3), GNAI1(3), GNAQ(10), GNB1(3), MAP3K7(7), PIK3CA(288), PIK3R1(53), PLCB1(22), PPP1R12B(28), PRKCA(5), PTK2B(13), ROCK1(27) 13177737 523 217 324 193 78 201 84 84 72 4 0.603 1.000 1.000 239 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(4), GRB2(9), HRAS(4), JAK2(48), JUN(2), MAP2K1(10), MAPK3(3), MPL(5), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), RAF1(13), RASA1(20), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), STAT5B(19), THPO(5) 15708798 569 217 367 200 80 228 96 90 72 3 0.311 1.000 1.000 240 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), IGF1(6), IGF1R(17), IRS1(17), JUN(2), MAP2K1(10), MAPK3(3), MAPK8(11), PIK3CA(288), PIK3R1(53), PTPN11(31), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SRF(4) 12482449 527 216 333 183 79 209 97 83 58 1 0.0937 1.000 1.000 241 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(5), CXCL12(2), CXCR4(6), GNAI1(3), GNAQ(10), GNB1(3), HRAS(4), MAP2K1(10), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(19), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), PTK2(24), PTK2B(13), PXN(2), RAF1(13), RELA(9) 13799166 500 214 325 196 73 200 95 81 50 1 0.597 1.000 1.000 242 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(14), ALG6(5), CCKBR(12), CCR2(7), CCR3(9), CCR5(11), CELSR1(27), CELSR2(31), CELSR3(27), CHRM2(25), CHRM3(21), CIDEB(1), CXCR3(4), EDNRA(8), EMR2(7), EMR3(18), F2R(11), FSHR(16), GHRHR(2), GNRHR(9), GPR116(16), GPR132(6), GPR133(15), GPR143(4), GPR17(2), GPR18(3), GPR55(2), GPR56(5), GPR61(9), GPR77(3), GPR84(5), GPR88(4), GRM1(32), GRPR(4), HRH4(6), LGR6(8), LPHN2(26), LPHN3(26), NTSR1(5), OR2M4(15), OR8G1(3), OR8G2(9), P2RY11(5), P2RY13(18), PTGFR(7), SMO(11), SSTR2(4), TAAR5(8), TSHR(55), VN1R1(7) 31014857 588 214 515 188 171 132 62 137 85 1 0.0457 1.000 1.000 243 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(19), HLA-A(23), IL18(3), ITGB1(12), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LAT(2), MAP2K1(10), MAPK3(3), PAK1(10), PIK3CA(288), PIK3R1(53), PTK2B(13), PTPN6(4), RAC1(2), SYK(5), VAV1(22) 9656791 486 214 310 172 61 196 86 82 59 2 0.312 1.000 1.000 244 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(11), BAD(1), BCL2L1(1), CASP9(5), CDC42(2), CHUK(23), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(10), MAPK3(3), NFKB1(8), PIK3CA(288), PIK3R1(53), RAC1(2), RAF1(13), RALA(7), RALBP1(6), RALGDS(7), RELA(9), RHOA(12) 9707484 470 214 289 156 75 190 95 63 47 0 0.0210 1.000 1.000 245 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 88 ACTB(4), BAD(1), BCL2(2), CABIN1(22), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(6), CD3E(2), CD3G(15), CD69(2), CDKN1A(2), CNR1(10), CREBBP(68), CSNK2A1(7), CSNK2B(2), CTLA4(4), EGR2(14), EGR3(6), EP300(42), FCER1A(5), FCGR3A(4), FOS(4), FOSL1(1), GATA3(17), GATA4(4), GRLF1(18), GSK3A(6), GSK3B(16), HRAS(4), ICOS(2), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL13(2), IL1B(4), IL2(4), IL2RA(3), IL3(6), IL4(5), IL6(5), IL8(5), ITK(21), KPNA5(12), MAPK14(7), MAPK8(11), MAPK9(10), MEF2A(5), MEF2D(3), MYF5(5), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB2(4), NFKBIB(5), NFKBIE(4), NPPB(4), NUP214(18), OPRD1(6), P2RX7(12), PAK1(10), PIN1(2), PPIA(1), PPP3CB(10), PPP3CC(5), PPP3R1(3), PTPRC(27), RELA(9), RPL13A(1), SFN(1), SLA(8), SP1(6), SP3(10), TGFB1(2), TNF(1), TRAF2(8), TRPV6(14), VAV1(22), VAV2(18), VAV3(27), XPO5(8) 44260971 711 213 649 248 208 172 80 142 109 0 0.255 1.000 1.000 246 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BTRC(7), CSNK1A1(3), CSNK1A1L(8), CSNK1D(14), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(6), DHH(4), FBXW11(12), GLI1(19), GLI2(22), GLI3(37), GSK3B(16), HHIP(15), IHH(5), LRP2(114), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(130), PTCH2(19), RAB23(3), SHH(3), SMO(11), STK36(16), SUFU(5), WNT1(7), WNT10A(2), WNT10B(5), WNT11(6), WNT16(9), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3) 28682929 631 213 546 227 204 140 67 122 95 3 0.437 1.000 1.000 247 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 104 A4GNT(5), ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG6(5), ALG8(12), ALG9(7), B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT5(4), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(9), CHST11(4), CHST12(4), CHST14(1), CHST2(11), CHST3(6), CHST4(6), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(12), EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), FUT11(2), FUT8(10), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GANAB(12), GCNT1(7), GCNT3(4), GCNT4(12), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), NDST1(9), NDST2(9), NDST3(15), NDST4(13), OGT(8), RPN1(4), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(5), STT3B(9), UST(10), WBSCR17(34), XYLT1(12), XYLT2(15) 54475008 784 211 729 279 269 127 87 165 136 0 0.757 1.000 1.000 248 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(11), BAD(1), GRB2(9), HRAS(4), IGF1R(17), IRS1(17), MAP2K1(10), MAPK1(3), MAPK3(3), PIK3CA(288), PIK3R1(53), RAF1(13), SHC1(13), SOS1(11), YWHAH(3) 9480494 456 211 272 152 65 186 92 65 47 1 0.0541 1.000 1.000 249 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(11), DPM2(1), GRB2(9), HRAS(4), KLK2(4), NTRK1(16), PIK3CA(288), PIK3R1(53), PLCG1(17), PRKCA(5), SHC1(13), SOS1(11) 8017310 432 211 254 165 42 186 90 67 46 1 0.526 1.000 1.000 250 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(4), CD3D(4), CD3E(2), CD3G(15), CD80(4), CD86(2), CTLA4(4), GRB2(9), HLA-DRA(11), HLA-DRB1(6), ICOS(2), IL2(4), ITK(21), LCK(8), PIK3CA(288), PIK3R1(53), PTPN11(31) 6575391 468 210 274 159 46 210 87 72 50 3 0.110 1.000 1.000 251 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(11), CREB1(3), GRB2(9), HRAS(4), MAPK1(3), MAPK3(3), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NTRK1(16), PIK3CA(288), PIK3R1(53), PLCG1(17), RPS6KA1(9), SHC1(13) 9673636 458 210 284 172 59 193 91 67 47 1 0.512 1.000 1.000 252 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), AKT1(11), ANXA1(3), CALM2(1), CALM3(1), GNAS(35), GNB1(3), NFKB1(8), NOS3(21), NPPA(1), NR3C1(8), PIK3CA(288), PIK3R1(53), RELA(9), SYT1(14) 8574871 459 210 269 162 71 195 84 65 44 0 0.180 1.000 1.000 253 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(11), PIK3CA(288), PIK3R1(53), PLCB1(22), PLCG1(17), PRKCA(5), VAV1(22) 6803008 418 210 250 160 52 185 85 63 33 0 0.533 1.000 1.000 254 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(11), AKT2(7), AKT3(7), CDKN1A(2), ELK1(4), GRB2(9), HRAS(4), MAP2K1(10), MAP2K2(2), NGFR(4), NTRK1(16), PIK3CA(288), PIK3CD(10), SHC1(13), SOS1(11) 7874228 398 210 241 157 54 156 91 66 30 1 0.582 1.000 1.000 255 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(38), CD28(4), CD3D(4), CSK(3), CTLA4(4), DAG1(8), EPHB2(15), FBXW7(119), GRAP2(3), GRB2(9), ITK(21), ITPKA(3), ITPKB(14), LAT(2), LCK(8), LCP2(9), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLCG1(17), PTPRC(27), RAF1(13), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), SOS1(11), SOS2(15), VAV1(22), ZAP70(12) 27476535 510 209 426 175 132 125 57 106 90 0 0.288 1.000 1.000 256 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 82 AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHX58(4), ENPP1(17), ENPP3(10), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), G6PC(4), G6PC2(2), GAA(14), GANC(8), GBA(4), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), IFIH1(20), LYZL1(4), MGAM(26), MOV10L1(16), NUDT5(1), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SI(24), SKIV2L2(11), SMARCA2(19), SMARCA5(13), TREH(6), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UXS1(8) 64682837 798 208 738 240 226 141 97 180 151 3 0.0787 1.000 1.000 257 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), DPM2(1), ELK1(4), FOS(4), GRB2(9), HRAS(4), JUN(2), KLK2(4), MAP2K1(10), MAPK3(3), MAPK8(11), NGFR(4), PIK3CA(288), PIK3R1(53), PLCG1(17), RAF1(13), SHC1(13), SOS1(11) 9657767 458 208 278 163 62 190 89 69 47 1 0.202 1.000 1.000 258 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(11), AKT2(7), AKT3(7), ASAH1(4), BRAF(111), DAG1(8), DRD2(7), EGFR(104), EPHB2(15), GRB2(9), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PI3(2), PIK3CB(5), PITX2(2), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), RAF1(13), RGS20(9), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT3(10), TERF2IP(3) 29425467 604 208 495 205 143 150 76 163 71 1 0.294 1.000 1.000 259 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(11), BAD(1), CHRNB1(10), CHRNG(6), MUSK(13), PIK3CA(288), PIK3R1(53), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(8), YWHAH(3) 8095453 438 207 269 165 54 186 87 67 44 0 0.522 1.000 1.000 260 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(11), BAD(1), CASP9(5), CHUK(23), GH1(4), GHR(12), NFKB1(8), NFKBIA(1), PDPK1(4), PIK3CA(288), PIK3R1(53), PPP2CA(3), RELA(9), YWHAH(3) 7380117 425 206 253 152 53 183 85 67 37 0 0.104 1.000 1.000 261 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), PAK1(10), PDGFRA(56), PIK3CA(288), PIK3R1(53), RAC1(2), WASL(16) 7127008 453 205 279 166 47 193 90 81 40 2 0.161 1.000 1.000 262 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(37), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ADIPOR1(2), ADIPOR2(5), AKT1(11), AKT2(7), AKT3(7), CAMKK1(2), CAMKK2(8), CD36(3), CHUK(23), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), G6PC(4), G6PC2(2), IKBKB(7), IKBKG(2), IRS1(17), IRS4(30), JAK1(20), JAK2(48), JAK3(27), LEP(1), LEPR(15), MAPK10(14), MAPK8(11), MAPK9(10), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NPY(5), PCK1(3), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKCQ(15), PTPN11(31), RELA(9), RXRA(8), RXRB(7), RXRG(10), SLC2A1(5), SLC2A4(7), STAT3(10), STK11(36), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5) 41017653 674 205 591 212 185 176 90 134 87 2 0.0166 1.000 1.000 263 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(11), CAT(7), GH1(4), GHR(12), HRAS(4), IGF1(6), IGF1R(17), PIK3CA(288), PIK3R1(53), SHC1(13), SOD2(4) 6687879 419 205 247 154 53 173 85 66 41 1 0.307 1.000 1.000 264 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(22), BDKRB1(3), BDKRB2(4), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(14), C2(6), C3(23), C3AR1(10), C4A(3), C4BPA(6), C4BPB(1), C5(20), C5AR1(7), C6(24), C7(10), C8A(11), C8B(22), C8G(1), C9(11), CD46(3), CD55(7), CFB(5), CFH(25), CFI(9), CPB2(10), CR1(19), CR2(20), F10(5), F11(8), F12(5), F13A1(12), F13B(10), F2(9), F2R(11), F3(1), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), KNG1(8), MASP1(19), MASP2(10), MBL2(3), PLAT(10), PLAU(6), PLAUR(7), PLG(23), PROC(3), PROS1(9), SERPINA1(6), SERPINA5(8), SERPINC1(8), SERPIND1(5), SERPINE1(8), SERPINF2(4), SERPING1(5), TFPI(6), THBD(3), VWF(30) 48091564 693 202 656 256 173 113 103 171 129 4 0.804 1.000 1.000 265 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(200), BMPR1B(14), CCND2(3), CDK4(3), CDKN1B(4), DAZL(2), DMC1(6), EGR1(11), ESR2(8), FSHR(16), GJA4(3), INHA(6), LHCGR(27), MLH1(62), MSH5(7), NCOR1(30), NR5A1(5), NRIP1(17), PGR(15), PRLR(8), PTGER2(2), SMPD1(9), VDR(3), ZP2(14) 17832591 475 202 385 163 88 144 47 98 92 6 0.420 1.000 1.000 266 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 62 AGTR1(12), AGTR2(15), ATP8A1(11), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CX3CR1(5), CXCR3(4), CXCR4(6), CXCR6(1), EDNRA(8), EDNRB(13), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(3), GRPR(4), LHCGR(27), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), NMBR(3), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), PPYR1(5), SSTR1(11), SSTR2(4), SSTR4(12), TAC4(4), TACR1(9), TACR2(4), TACR3(11), TRHR(7), TSHR(55) 25263072 500 197 445 186 153 118 57 122 50 0 0.255 1.000 1.000 267 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 ACTG1(6), APAF1(23), ARHGDIB(5), BAG4(10), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CHUK(23), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), GSN(4), LMNB1(9), LMNB2(2), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK8(11), MDM2(11), NFKB1(8), NFKBIA(1), NUMA1(21), PAK2(14), PRKCD(15), PRKDC(80), PSEN1(3), PSEN2(6), PTK2(24), RASA1(20), RB1(123), RELA(9), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8) 34100259 604 196 509 197 122 173 53 128 118 10 0.344 1.000 1.000 268 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CDH1(87), CLDN1(1), CTNNB1(99), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), RHOA(12), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3) 25582173 528 194 440 195 105 140 70 109 99 5 0.494 1.000 1.000 269 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CDH1(87), CLDN1(1), CTNNB1(99), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), RHOA(12), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3) 25582173 528 194 440 195 105 140 70 109 99 5 0.494 1.000 1.000 270 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(2), CHUK(23), DAXX(14), EGF(7), EGFR(104), ETS1(6), ETS2(4), FOS(4), HOXA7(3), HRAS(4), IKBKB(7), JUN(2), MAP2K1(10), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK1(3), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), NFKB1(8), NFKBIA(1), PPP2CA(3), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), RAF1(13), RELA(9), RIPK1(7), SP1(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 24664285 432 188 383 155 114 127 61 84 45 1 0.255 1.000 1.000 271 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), BTRC(7), CDC16(5), CDC20(3), CDC23(12), CDC26(1), CDC27(16), CUL1(16), CUL2(14), CUL3(8), FBXW11(12), FBXW7(119), FZR1(3), ITCH(7), SKP1(2), SKP2(3), SMURF1(7), SMURF2(6), TCEB2(1), UBA1(8), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D4(1), UBE2E1(4), UBE2E2(3), UBE2E3(1), VHL(83), WWP1(18), WWP2(8) 21191379 410 185 325 150 104 102 42 95 65 2 0.560 1.000 1.000 272 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(104), ELK1(4), GNAS(35), GNB1(3), GRB2(9), HRAS(4), IGF1R(17), ITGB1(12), KLK2(4), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MYC(5), NGFR(4), PDGFRA(56), PPP2CA(3), PTPRR(11), RAF1(13), RPS6KA1(9), RPS6KA5(10), SHC1(13), SOS1(11), SRC(3), STAT3(10) 16844829 367 183 309 134 101 111 50 65 37 3 0.323 1.000 1.000 273 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(5), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CFLAR(2), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNB1(9), LMNB2(2), MAP2K4(32), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), PTPN13(20), RB1(123), RIPK2(5), SPTAN1(25) 20748677 431 179 361 151 64 124 44 107 81 11 0.700 1.000 1.000 274 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(35), AR(20), ESR1(20), ESR2(8), ESRRA(26), HNF4A(8), NPM1(2), NR0B1(10), NR1D1(7), NR1D2(7), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(3), NR2C2(11), NR2E1(12), NR2F1(5), NR2F2(10), NR3C1(8), NR4A1(3), NR4A2(13), NR5A1(5), NR5A2(9), PGR(15), PPARA(7), PPARD(4), PPARG(4), RARA(5), RARB(18), RARG(10), ROR1(19), RORA(6), RORC(5), RXRA(8), RXRB(7), RXRG(10), THRA(6), THRB(14), VDR(3) 20506314 384 179 342 127 123 61 46 79 73 2 0.411 1.000 1.000 275 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(5), BAG4(10), CASP2(8), CASP3(3), CASP8(19), CRADD(3), DFFA(4), DFFB(2), FADD(1), JUN(2), LMNB1(9), LMNB2(2), MADD(22), MAP2K4(32), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), RB1(123), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TRAF2(8) 19341284 430 176 358 140 78 120 38 98 84 12 0.360 1.000 1.000 276 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(7), CDC40(6), CLK2(3), CLK3(7), CLK4(17), COL2A1(19), CPSF1(14), CPSF2(10), CPSF3(8), CPSF4(4), CSTF1(4), CSTF2(2), CSTF2T(11), CSTF3(11), DDIT3(4), DDX1(14), DDX20(6), DHX15(8), DHX16(18), DHX38(12), DHX8(14), DHX9(12), DICER1(23), DNAJC8(5), FUS(2), GIPC1(4), METTL3(5), NCBP1(8), NCBP2(2), NONO(12), NUDT21(1), NXF1(9), PABPN1(2), PAPOLA(7), PHF5A(1), POLR2A(12), PPM1G(3), PRPF18(4), PRPF3(9), PRPF4(9), PRPF4B(16), PRPF8(17), PSKH1(2), PTBP1(4), PTBP2(13), RBM17(6), RBM5(12), RNGTT(7), RNMT(5), RNPS1(1), SF3A1(10), SF3A2(4), SF3A3(1), SF3B1(17), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(2), SNRPA1(2), SNRPB(2), SNRPB2(3), SNRPD1(2), SNRPD3(1), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(8), SRPK2(9), SRRM1(15), SUPT5H(19), TXNL4A(2), U2AF1(3), U2AF2(6), XRN2(10) 54140754 562 174 525 181 157 83 61 136 124 1 0.816 1.000 1.000 277 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 40 ADAM17(11), APH1A(2), CREBBP(68), CTBP1(5), CTBP2(13), DLL1(6), DLL3(6), DLL4(5), DTX1(6), DTX2(8), DTX3(2), DTX3L(10), DTX4(8), DVL2(11), DVL3(8), EP300(42), HDAC1(5), HDAC2(8), HES1(2), JAG1(15), LFNG(5), MAML1(10), MAML2(8), MAML3(4), MFNG(1), NCOR2(38), NCSTN(6), NOTCH2(29), NOTCH3(27), NOTCH4(15), NUMB(10), NUMBL(6), PSEN1(3), PSEN2(6), PSENEN(2), PTCRA(4), RBPJ(16), RBPJL(11), RFNG(1), SNW1(9) 29172537 452 171 411 203 133 85 61 74 98 1 0.993 1.000 1.000 278 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(19), CALR(1), CANX(5), CD4(4), CD74(3), CD8A(1), CD8B(4), CIITA(15), CREB1(3), CTSB(3), CTSL1(6), CTSS(4), HLA-A(23), HLA-B(19), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA1(25), HLA-DQA2(4), HLA-DQB1(1), HLA-DRA(11), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), HLA-G(12), HSP90AA1(7), HSP90AB1(2), HSPA5(3), IFI30(3), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(9), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(9), KIR2DL3(20), KIR2DL4(5), KIR2DS4(4), KIR3DL1(6), KIR3DL2(6), KIR3DL3(10), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LGMN(1), LTA(1), NFYA(3), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(14), RFXANK(1), RFXAP(5), TAP1(7), TAP2(15), TAPBP(4) 21939337 430 171 362 109 64 75 60 95 111 25 0.0417 1.000 1.000 279 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(6), CDC34(2), CDK2(5), CUL1(16), FBXW7(119), RB1(123), TFDP1(10) 4496395 281 169 188 98 59 85 14 63 52 8 0.304 1.000 1.000 280 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1C1(2), AKR1C2(2), AKR1C4(10), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), CYP1A1(9), CYP1A2(10), CYP1B1(13), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2F1(6), CYP2S1(7), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTM5(10), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7) 29397341 418 169 367 112 109 84 43 108 73 1 0.0133 1.000 1.000 281 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CAT(7), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADHA(10), KMO(13), KYNU(8), MAOA(5), MAOB(6), SDS(3), TDO2(8), TPH1(2), WARS(3), WARS2(6) 28384452 414 169 390 114 141 83 45 101 43 1 0.00328 1.000 1.000 282 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(10), AGTR1(12), ATF2(6), CALM2(1), CALM3(1), EGFR(104), ELK1(4), GNAQ(10), GRB2(9), HRAS(4), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), MEF2A(5), MEF2C(15), MEF2D(3), PAK1(10), PRKCA(5), PTK2(24), PTK2B(13), RAC1(2), RAF1(13), SHC1(13), SOS1(11), SRC(3), SYT1(14) 17556149 373 167 327 134 79 103 49 88 52 2 0.465 1.000 1.000 283 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(7), ACADL(4), ACADM(9), ACOX1(11), ACOX2(7), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP27A1(4), CYP4A11(7), CYP4A22(13), CYP7A1(13), CYP8B1(9), DBI(2), EHHADH(13), FABP1(2), FABP2(8), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FADS2(10), GK(5), GK2(13), HMGCS2(5), ILK(3), LPL(12), ME1(11), MMP1(5), NR1H3(16), OLR1(9), PCK1(3), PCK2(6), PDPK1(4), PLTP(10), PPARA(7), PPARD(4), PPARG(4), RXRA(8), RXRB(7), RXRG(10), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(6), SLC27A4(3), SLC27A5(7), SLC27A6(15), SORBS1(11), UBC(6), UCP1(8) 33574617 460 167 423 126 140 67 71 113 69 0 0.00355 1.000 1.000 284 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(1), AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), AFMID(2), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CARM1(3), CAT(7), CYP1A1(9), CYP1A2(10), CYP1B1(13), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADH(2), HADHA(10), HEMK1(1), HSD17B10(2), HSD17B4(9), INMT(3), KMO(13), KYNU(8), LCMT1(1), LCMT2(6), LNX1(14), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), NFX1(8), OGDH(13), OGDHL(12), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), TDO2(8), TPH1(2), TPH2(9), WARS(3), WARS2(6), WBSCR22(2) 30978743 386 166 361 128 120 74 48 95 49 0 0.219 1.000 1.000 285 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(12), AKT1(11), BDKRB2(4), CALM2(1), CALM3(1), CHRM1(4), CHRNA1(9), FLT1(34), FLT4(16), KDR(38), NOS3(21), PDE2A(10), PDE3A(19), PDE3B(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKG1(12), PRKG2(10), RYR2(122), SLC7A1(6), SYT1(14), TNNI1(2) 19429179 379 165 362 140 106 79 47 92 53 2 0.551 1.000 1.000 286 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(38), CSF1R(15), EGF(7), EGFR(104), GRB2(9), MET(48), PDGFRA(56), PRKCA(5), SH3GLB1(5), SH3GLB2(6), SH3KBP1(8), SRC(3) 10372119 304 161 263 129 42 126 45 68 21 2 0.736 1.000 1.000 287 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), CARM1(3), DBH(8), DCT(17), DDC(5), ECH1(2), ESCO1(16), ESCO2(13), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HEMK1(1), HGD(5), HPD(6), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), MYST3(28), MYST4(25), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SH3GLB1(5), TAT(14), TPO(29), TYR(9), TYRP1(6), WBSCR22(2) 30007730 403 161 360 150 124 80 46 98 54 1 0.576 1.000 1.000 288 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(13), ADCY4(14), ADCY6(13), ADCY8(30), CACNA1A(27), CACNA1B(36), GNAS(35), GNAT3(4), GNB1(3), GNB3(6), GNG3(1), GRM4(15), ITPR3(39), KCNB1(19), PDE1A(8), PLCB2(10), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(8), SCNN1B(7), SCNN1G(9), TAS1R1(12), TAS1R2(20), TAS2R1(4), TAS2R10(6), TAS2R13(9), TAS2R14(1), TAS2R16(5), TAS2R3(5), TAS2R38(6), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(3), TAS2R46(1), TAS2R5(2), TAS2R50(9), TAS2R60(3), TAS2R7(3), TAS2R8(8), TAS2R9(1), TRPM5(5) 27085932 430 161 403 148 163 55 45 97 69 1 0.406 1.000 1.000 289 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 62 ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), CDS1(13), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CHPT1(3), CRLS1(1), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), ESCO1(16), ESCO2(13), ETNK1(3), ETNK2(11), GNPAT(17), GPAM(4), GPD1(3), GPD1L(4), GPD2(10), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(28), MYST4(25), NAT6(2), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(11), SH3GLB1(5) 33013171 422 159 377 160 115 75 58 107 66 1 0.844 1.000 1.000 290 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(5), BAD(1), BRAF(111), CREB1(3), CREB3(5), CREB5(5), DUSP4(6), DUSP6(6), DUSP9(9), EEF2K(10), GRB2(9), MAP2K1(10), MAP2K2(2), MAP3K8(4), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MOS(8), NFKB1(8), RAP1A(1), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), SHC1(13), SOS1(11), SOS2(15), TRAF3(10) 15323530 310 159 229 103 60 83 34 86 46 1 0.299 1.000 1.000 291 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(29), CARM1(3), CCND1(2), CREBBP(68), EP300(42), ERCC3(18), ESR1(20), GRIP1(12), GTF2A1(5), GTF2E1(13), GTF2F1(5), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), MEF2C(15), NCOR2(38), NR0B1(10), NRIP1(17), PELP1(11), POLR2A(12), SRA1(2), TBP(2) 23481084 379 157 340 172 102 76 40 68 93 0 0.998 1.000 1.000 292 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CHEK1(10), MYT1(20), WEE1(15), YWHAH(3) 7312311 275 155 218 96 49 98 22 56 44 6 0.432 1.000 1.000 293 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(10), AGTR2(15), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDK5(2), F2(9), FYN(15), GNA11(8), GNAI1(3), GNB1(3), GRB2(9), HRAS(4), JAK2(48), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MAPT(10), MYLK(29), PLCG1(17), PRKCA(5), PTK2B(13), RAF1(13), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), SYT1(14) 21647818 348 154 298 125 89 89 43 67 57 3 0.555 1.000 1.000 294 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AGK(6), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CEL(12), DAK(7), DGAT1(5), DGAT2(4), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), GK(5), GK2(13), GLA(7), GLB1(9), GPAM(4), LCT(39), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(12), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3) 29415673 404 154 375 150 111 64 60 124 44 1 0.546 1.000 1.000 295 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(6), AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PRIM1(5), PRIM2(2), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), TK1(2), TK2(2), TXNRD1(9), TXNRD2(8), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UPB1(7), UPP1(5), UPP2(4), UPRT(6) 42323224 484 153 466 149 127 84 77 122 74 0 0.0440 1.000 1.000 296 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), HSD3B7(3), NSD1(25), OGDH(13), OGDHL(12), PIPOX(8), PLOD1(7), PLOD2(9), PLOD3(6), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SETD1A(20), SETD7(7), SETDB1(18), SHMT1(6), SHMT2(5), SPCS1(2), SPCS3(2), SUV39H1(4), SUV39H2(6), TMLHE(3) 28796492 342 152 319 103 117 55 35 77 58 0 0.126 1.000 1.000 297 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), F10(5), F11(8), F12(5), F2(9), F2R(11), F5(30), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), PROC(3), PROS1(9), SERPINC1(8), SERPING1(5) 23443152 331 152 309 132 72 62 48 88 59 2 0.705 1.000 1.000 298 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(7), AADAC(5), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ACSM1(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH7A1(6), ALDH9A1(4), BDH1(3), BDH2(2), DDHD1(39), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADH(2), HADHA(10), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), HSD3B7(3), ILVBL(8), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(7), PDHA2(14), PDHB(3), PLA1A(8), PPME1(2), PRDX6(4), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 21266652 312 151 252 80 91 53 33 65 70 0 0.0220 1.000 1.000 299 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 90 ANK2(71), B3GALT4(4), CDR1(5), DGKI(18), FAU(1), IL6ST(14), MRPL19(4), PIGK(10), RPL10(2), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL22(24), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(5), RPL6(2), RPL7(3), RPL7A(1), RPL8(3), RPL9(3), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(1), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS4X(1), RPS5(2), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), RPS7(1), RPS9(3), RPSA(1), SLC36A2(3), TBC1D10C(8), TSPAN9(4), UBA52(3), UBB(2), UBC(6) 25829242 350 151 312 95 84 66 45 78 75 2 0.196 1.000 1.000 300 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(38), EGF(7), EGFR(104), GRB2(9), HRAS(4), MAP2K1(10), MAPK1(3), MAPK3(3), PTPRB(19), RAF1(13), RASA1(20), SHC1(13), SOS1(11), SPRY1(9), SPRY2(2), SPRY4(7), SRC(3) 12353674 275 151 234 95 55 89 44 53 33 1 0.235 1.000 1.000 301 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHFR(1), DHX58(4), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), FPGS(4), GGH(1), IFIH1(20), MOV10L1(16), NUDT5(1), QDPR(2), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SKIV2L2(11), SMARCA2(19), SMARCA5(13), SPR(7) 31802044 417 149 375 138 132 77 48 86 72 2 0.370 1.000 1.000 302 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(8), ACOX1(11), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP4A11(7), CYP4A22(13), DCI(3), ECHS1(3), EHHADH(13), GCDH(6), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), PECI(2) 25360409 341 148 314 97 93 67 56 83 42 0 0.00463 1.000 1.000 303 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(12), CAPN1(2), CAPN2(8), CAPNS1(4), CAPNS2(4), CXCR3(4), EGF(7), EGFR(104), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTK2(24), PXN(2), TLN1(21) 17131857 282 148 262 114 66 82 45 59 29 1 0.625 1.000 1.000 304 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(4), ARHGAP1(3), ARHGAP4(7), ARHGAP5(43), ARHGAP6(10), ARHGEF1(13), ARHGEF11(20), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), BAIAP2(6), CFL1(2), DIAPH1(7), GSN(4), LIMK1(7), MYL2(2), MYLK(29), OPHN1(7), PIP5K1A(7), PIP5K1B(3), PPP1R12B(28), ROCK1(27), SRC(3), TLN1(21), VCL(9) 23951080 291 148 233 85 78 58 26 53 71 5 0.362 1.000 1.000 305 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(6), ACSS2(9), ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), G6PC2(2), GALM(3), GAPDH(2), GAPDHS(3), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3) 29458993 371 147 336 123 116 69 39 91 56 0 0.244 1.000 1.000 306 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), BCR(11), CAPN1(2), CAPNS1(4), CAPNS2(4), CRKL(5), CSK(3), FYN(15), GRB2(9), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K1(10), MAP2K2(2), MAPK1(3), MAPK3(3), MAPK8(11), PPP1R12B(28), PTK2(24), PXN(2), RAF1(13), RAP1A(1), ROCK1(27), SHC1(13), SOS1(11), SRC(3), TLN1(21), VCL(9), ZYX(2) 23248636 313 146 262 113 90 56 36 59 66 6 0.694 1.000 1.000 307 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), RB1(123), RBL1(18), TFDP1(10) 8220397 237 145 188 88 41 74 20 59 35 8 0.500 1.000 1.000 308 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AKR1B1(3), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), CEL(12), DGAT1(5), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), GK(5), GLA(7), GLB1(9), LCT(39), LIPC(5), LIPF(1), LIPG(4), LPL(12), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PPAP2A(2), PPAP2B(2), PPAP2C(3) 23988620 355 145 326 120 97 65 54 99 39 1 0.179 1.000 1.000 309 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(28), ATP4A(17), ATP4B(3), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), COX10(6), COX15(5), COX17(1), COX4I1(5), COX4I2(3), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(5), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(2), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(7), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(3), NDUFC1(1), NDUFC2(2), NDUFS1(14), NDUFS2(3), NDUFS3(4), NDUFS4(1), NDUFS5(1), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(4), PPA1(3), PPA2(3), SDHA(12), SDHB(3), SDHD(4), TCIRG1(6), UQCRB(2), UQCRC1(4), UQCRC2(11), UQCRFS1(3), UQCRH(1) 29093293 387 144 354 115 126 77 46 67 71 0 0.0218 1.000 1.000 310 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(6), ABO(5), B3GALNT1(5), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(3), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALNT1(12), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT6(10), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GBGT1(1), GCNT2(24), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGX(2), PIGZ(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(12), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7), UGCG(9) 23580958 324 142 291 101 100 59 24 77 63 1 0.393 1.000 1.000 311 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(23), CREBBP(68), DUSP1(6), EP300(42), IKBKB(7), IL1B(4), IL8(5), MAP2K3(8), MAP2K6(4), MAP3K14(6), MAP3K7(7), MAPK14(7), MYD88(3), NFKB1(8), NFKBIA(1), NR3C1(8), RELA(9), TGFBR1(17), TGFBR2(24), TLR2(7), TNF(1) 15093105 265 142 236 97 73 77 32 48 34 1 0.456 1.000 1.000 312 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(6), ACTG2(6), ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), CDC42(2), CFL1(2), CFL2(2), FLNA(24), FLNC(36), FSCN1(5), FSCN3(5), GDI1(1), GDI2(2), LIMK1(7), MYH2(37), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PFN2(4), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), VASP(4), WASF1(3), WASL(16) 22575562 347 142 319 121 98 55 42 78 69 5 0.457 1.000 1.000 313 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ENPP1(17), ENPP3(10), G6PC(4), GAA(14), GANAB(12), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), MGAM(26), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), SI(24), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UXS1(8) 30561250 340 142 324 102 97 62 43 70 67 1 0.157 1.000 1.000 314 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(23), BAD(1), BAX(14), BCL2(2), BCL2A1(2), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CD40(6), CD40LG(10), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), IKBKE(8), LTA(1), NFKB1(8), NFKBIA(1), NGFR(4), NR3C1(8), NTRK1(16), PTPN13(20), RIPK1(7), SFRS2IP(3), TFG(8), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10), TRAF6(4) 21904614 276 141 242 130 59 65 27 58 66 1 1.000 1.000 1.000 315 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPS(5), CDS1(13), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CLC(2), CPT1B(13), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), ETNK1(3), GNPAT(17), GPD1(3), GPD2(10), LCAT(4), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(6), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB2(10), PLCG1(17), PLCG2(23), PPAP2A(2), PPAP2B(2), PPAP2C(3) 24504695 330 141 300 121 103 51 47 77 52 0 0.649 1.000 1.000 316 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(22), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(4), GNAI1(3), GNAQ(10), GNAS(35), GNB1(3), HRAS(4), JUN(2), MAP2K1(10), MAPK3(3), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RAF1(13), RPS6KA3(13), SYT1(14) 16699581 244 139 207 85 96 61 23 34 30 0 0.202 1.000 1.000 317 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 33 AKT1(11), ATF1(5), CDC42(2), CREB1(3), CREB3(5), CREB5(5), DUSP1(6), DUSP10(5), EEF2K(10), ELK1(4), IL1R1(6), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K10(10), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MKNK1(2), MKNK2(6), MYEF2(14), NFKB1(8), NR2C2(11), SRF(4), TRAF6(4) 16863725 263 139 233 67 65 47 42 57 50 2 0.0113 1.000 1.000 318 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3) 25046159 333 138 298 102 100 70 36 81 46 0 0.0773 1.000 1.000 319 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3) 25046159 333 138 298 102 100 70 36 81 46 0 0.0773 1.000 1.000 320 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(8), ADC(3), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EARS2(3), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GFPT2(11), GLS(2), GLS2(6), GLUD1(4), GLUD2(20), GLUL(4), GMPS(16), GNPNAT1(1), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSR(5), GSS(8), NADSYN1(4), NAGK(7), PPAT(5), QARS(13) 20449404 273 138 255 69 78 55 34 74 32 0 0.00706 1.000 1.000 321 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(8), ACAA1(7), ACAA2(2), ACADM(9), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), AOX1(12), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(3), ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HADHB(9), HIBADH(2), HIBCH(2), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), OXCT2(3), PCCA(11), PCCB(5) 22816079 281 138 256 67 84 53 35 56 52 1 0.00249 1.000 1.000 322 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG5(4), ALG6(5), ALG8(12), ALG9(7), B4GALT1(7), B4GALT2(7), B4GALT3(6), DAD1(3), DDOST(4), DHDDS(4), DPAGT1(12), DPM1(3), FUT8(10), GANAB(12), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), RFT1(3), RPN1(4), RPN2(6), ST6GAL1(3), STT3B(9) 21057619 289 137 261 95 74 52 32 74 57 0 0.684 1.000 1.000 323 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 30 ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), DRD1(9), DRD2(7), DRD3(5), DRD5(10), HRH1(4), HRH2(15), HTR1A(15), HTR1B(11), HTR1D(4), HTR1E(15), HTR1F(9), HTR2A(19), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12) 12272501 272 137 239 93 112 56 33 41 29 1 0.0595 1.000 1.000 324 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(11), AKT2(7), AKT3(7), ARHGEF11(20), BCL2(2), CDC42(2), DLG4(10), GNA13(3), IKBKG(2), LPA(28), MAP2K4(32), MAP3K1(18), MAP3K5(14), MAPK8(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PI3(2), PIK3CB(5), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RDX(13), ROCK1(27), ROCK2(15), SERPINA4(5), SRF(4) 24700855 334 136 307 102 93 54 37 83 61 6 0.290 1.000 1.000 325 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(22), CD3D(4), CD3E(2), CD3G(15), CD4(4), CREBBP(68), CSK(3), GNAS(35), GNB1(3), HLA-DRA(11), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12) 11252430 245 135 205 81 77 64 23 35 43 3 0.270 1.000 1.000 326 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), AGMAT(3), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH4A1(7), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), MAOA(5), MAOB(6), NOS1(23), NOS3(21), OAT(3), ODC1(5), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(6), RARS(7), SMS(4) 22251610 305 135 276 96 102 57 41 60 45 0 0.126 1.000 1.000 327 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), CSK(3), CTNNA1(26), CTNNA2(33), CTNNB1(99), PECAM1(4), PTK2(24), PXN(2), SRC(3), VCL(9) 9331520 238 135 196 98 54 67 26 62 28 1 0.873 1.000 1.000 328 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(22), CD3D(4), CD3E(2), CD3G(15), CD4(4), CREBBP(68), CSK(3), GNAS(35), GNB1(3), HLA-DRA(11), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12) 11252430 245 135 205 81 77 64 23 35 43 3 0.270 1.000 1.000 329 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(8), ACACA(30), ACACB(37), ACADM(9), ACAT1(7), ACAT2(8), ACSS1(6), ACSS2(9), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), HIBCH(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SUCLA2(6), SUCLG1(2), SUCLG2(1) 21024607 284 135 260 60 90 41 42 62 49 0 0.000418 1.000 1.000 330 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(6), CDC42(2), CREB1(3), DAXX(14), DDIT3(4), ELK1(4), GRB2(9), HRAS(4), HSPB2(2), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MYC(5), PLA2G4A(13), RAC1(2), RIPK1(7), RPS6KA5(10), SHC1(13), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8) 18692927 279 135 255 83 82 60 33 57 45 2 0.142 1.000 1.000 331 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(6), CHUK(23), ELK1(4), FOS(4), IKBKB(7), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), PPARA(7), RELA(9), TIRAP(5), TLR10(11), TLR2(7), TLR3(13), TLR4(15), TLR6(12), TLR7(15), TLR9(12), TOLLIP(5), TRAF6(4) 18619675 278 135 264 74 68 54 31 73 50 2 0.0376 1.000 1.000 332 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(13), AGT(10), AGTR2(15), EDN1(3), EDNRA(8), EDNRB(13), EGF(7), EGFR(104), FOS(4), HRAS(4), JUN(2), MYC(5), NFKB1(8), PLCG1(17), PRKCA(5), RELA(9) 10655862 227 134 202 92 49 65 37 47 29 0 0.763 1.000 1.000 333 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(5), GTF2A1L(9), GTF2A2(1), GTF2B(11), GTF2E1(13), GTF2E2(1), GTF2F1(5), GTF2H1(4), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(16), TAF1(26), TAF10(1), TAF12(3), TAF13(3), TAF1L(50), TAF2(17), TAF4(9), TAF4B(9), TAF5(11), TAF5L(2), TAF6(8), TAF6L(5), TAF7(2), TAF7L(12), TAF9(2), TAF9B(1), TBPL1(3), TBPL2(2) 18917334 240 134 216 73 65 42 28 66 38 1 0.239 1.000 1.000 334 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), IL6(5), IL6R(7), IL6ST(14), JAK1(20), JAK2(48), JAK3(27), JUN(2), MAP2K1(10), MAPK3(3), PTPN11(31), RAF1(13), SHC1(13), SOS1(11), SRF(4), STAT3(10) 12176668 246 134 189 74 56 84 32 39 32 3 0.105 1.000 1.000 335 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(8), BRAF(111), CAMP(1), CREB1(3), CREB3(5), CREB5(5), MAPK1(3), RAF1(13), SNX13(36), SRC(3), TERF2IP(3) 5942349 195 134 109 57 17 51 17 91 19 0 0.268 1.000 1.000 336 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(27), EEF1A2(8), EEF1B2(1), EEF1D(9), EEF1G(1), EEF2(7), EEF2K(10), EIF1AX(1), EIF2AK1(16), EIF2AK2(3), EIF2AK3(13), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF4A2(10), EIF4EBP2(3), EIF4G1(17), EIF4G3(16), EIF5(6), EIF5A(2), EIF5B(20), ETF1(10), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(16), PAIP1(4), SLC35A4(3) 22132645 276 134 240 71 61 64 28 57 66 0 0.0367 1.000 1.000 337 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), DBH(8), DCT(17), DDC(5), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HGD(5), HPD(6), MAOA(5), MAOB(6), PNMT(3), TAT(14), TPO(29), TYR(9) 15935467 238 134 206 82 83 45 27 56 27 0 0.201 1.000 1.000 338 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), ESCO1(16), ESCO2(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), PRDX6(4), SH3GLB1(5), TAT(14), TPO(29) 17599179 272 132 234 87 100 46 27 53 45 1 0.222 1.000 1.000 339 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ACY3(4), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(9), ASPA(6), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(11), HARS(6), HARS2(6), HDC(8), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), PRPS1(8), PRPS2(6), UROC1(7), WBSCR22(2) 19920970 268 131 246 74 76 57 36 64 35 0 0.0189 1.000 1.000 340 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), HIBADH(2), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), PCCA(11), PCCB(5), SDS(3) 18974195 268 131 243 57 77 50 37 59 44 1 0.000122 1.000 1.000 341 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(11), CALM2(1), CALM3(1), CD79A(6), CD79B(2), ELK1(4), FOS(4), GRB2(9), HRAS(4), JUN(2), LYN(13), MAP2K1(10), MAP3K1(18), MAPK14(7), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), RAC1(2), RAF1(13), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22) 19019390 261 130 233 82 81 58 33 47 41 1 0.155 1.000 1.000 342 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(10), AKR1D1(8), ARSD(9), ARSE(4), CARM1(3), CYP11B1(13), CYP11B2(7), CYP19A1(8), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), WBSCR22(2) 24978580 299 130 282 94 80 55 35 71 58 0 0.197 1.000 1.000 343 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(30), ACACB(37), ACAT1(7), ACAT2(8), ACOT12(8), ACSS1(6), ACSS2(9), ACYP1(1), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PCK2(6), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4) 24117785 317 130 292 98 98 55 43 68 53 0 0.150 1.000 1.000 344 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(8), ASPH(12), COPS5(1), CREB1(3), EDN1(3), EP300(42), EPO(1), HIF1A(14), JUN(2), LDHA(10), NOS3(21), P4HB(6), VHL(83) 8362614 206 129 164 79 31 76 28 38 33 0 0.651 1.000 1.000 345 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(9), CFL1(2), GNAQ(10), GNAS(35), GNB1(3), HRAS(4), LIMK1(7), MAP2K1(10), MAPK1(3), MAPK3(3), MYL2(2), NOX1(4), PIK3C2G(19), PLCB1(22), PPP1R12B(28), PRKCA(5), PTK2(24), RAF1(13), ROCK2(15) 12760964 219 127 173 63 71 47 19 41 40 1 0.174 1.000 1.000 346 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(9), AARS2(13), CARS(10), CARS2(6), DARS(4), DARS2(7), EARS2(3), EPRS(23), FARS2(5), FARSA(6), FARSB(11), GARS(8), HARS(6), HARS2(6), IARS(9), IARS2(19), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), MTFMT(1), NARS(4), NARS2(8), PARS2(2), QARS(13), RARS(7), RARS2(7), SARS(5), SARS2(4), TARS(7), TARS2(9), VARS(7), VARS2(9), WARS(3), WARS2(6), YARS(4), YARS2(6) 27433192 289 127 282 69 95 40 38 71 45 0 0.00943 1.000 1.000 347 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(6), BCR(11), BLNK(1), ELK1(4), FOS(4), GRB2(9), HRAS(4), JUN(2), LYN(13), MAP2K1(10), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8IP3(11), PAPPA(33), RAC1(2), RPS6KA1(9), RPS6KA3(13), SHC1(13), SOS1(11), SYK(5), VAV1(22), VAV2(18), VAV3(27) 15724316 252 127 225 64 75 55 34 57 30 1 0.00541 1.000 1.000 348 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 ALOX12(3), ALOX12B(4), ALOX15(4), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP2U1(5), CYP4A11(7), CYP4A22(13), CYP4F2(12), CYP4F3(10), DHRS4(1), EPHX2(5), GGT1(9), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11) 20069034 250 126 231 84 76 37 36 63 38 0 0.370 1.000 1.000 349 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ACTG2(6), ADCY3(10), ADCY9(19), AK1(1), ARF1(1), ARF4(4), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ERO1L(3), GNAS(35), PDIA4(7), PLCG1(17), PLCG2(23), PRKCA(5), SEC61A1(9), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(13) 18845920 262 126 220 94 98 60 27 41 36 0 0.383 1.000 1.000 350 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ITPA(6), NME1(1), NT5C(1), NT5E(6), NT5M(3), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), RRM1(2), RRM2(5), TK1(2), TK2(2), TXNRD1(9), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UNG(3), UPB1(7), UPP1(5) 29198675 335 126 320 107 95 55 49 92 44 0 0.181 1.000 1.000 351 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(7), EGFR(104), MAP2K1(10), MAP3K1(18), MAPK14(7), NCOR2(38), RARA(5), RXRA(8), THRA(6), THRB(14) 8373926 217 124 191 80 52 61 33 41 30 0 0.577 1.000 1.000 352 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(28), ATP4B(3), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ATP7A(11), ATP7B(14), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3), PPA2(3), SDHA(12), SDHB(3), SHMT1(6), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1) 20258705 258 123 234 84 83 44 33 47 51 0 0.187 1.000 1.000 353 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(5), CALM2(1), CALM3(1), CRKL(5), GNAQ(10), GRB2(9), HRAS(4), JUN(2), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), PAK1(10), PLCG1(17), PRKCA(5), PTK2B(13), RAC1(2), RAF1(13), SHC1(13), SOS1(11), SRC(3), SYT1(14) 14364955 232 123 203 79 54 51 30 60 35 2 0.517 1.000 1.000 354 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(4), AKT1(11), AKT2(7), AKT3(7), DAG1(8), GNAQ(10), IKBKG(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PIK3CB(5), PITX2(2), PLD1(16), PLD2(7), PLD3(7), VN1R1(7) 21502783 273 123 263 93 87 55 38 57 36 0 0.276 1.000 1.000 355 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(8), F12(5), F13B(10), F2(9), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), LPA(28), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8), SERPINF2(4), VWF(30) 18220608 283 122 259 109 68 53 42 72 45 3 0.740 1.000 1.000 356 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), ELK1(4), FPR1(5), GNA15(5), GNB1(3), HRAS(4), MAP2K1(10), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NCF1(4), NCF2(8), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PAK1(10), PIK3C2G(19), PLCB1(22), PPP3CA(3), PPP3CB(10), PPP3CC(5), RAC1(2), RAF1(13), RELA(9), SYT1(14) 18933125 252 122 232 88 84 47 31 54 35 1 0.347 1.000 1.000 357 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(8), ACACA(30), ACADL(4), ACADM(9), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), LDHA(10), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SDS(3), SUCLA2(6), SUCLG1(2), SUCLG2(1) 17558286 255 122 230 52 77 42 38 55 43 0 0.000332 1.000 1.000 358 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(6), CDC7(23), CDK2(5), DIAPH2(24), GMNN(3), MCM10(10), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), PRIM1(5), RFC1(20), RFC2(2), RFC4(8), RFC5(6), RPA1(12), RPA2(1), RPA3(4), RPA4(5), UBA52(3), UBB(2), UBC(6) 25578550 297 121 260 95 57 52 40 75 72 1 0.529 1.000 1.000 359 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(7), ACAA2(2), ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1B10(3), AKR1C4(10), AKR1D1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), HSD3B7(3), LIPA(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SLC27A5(7), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2) 16332670 230 121 206 61 60 50 35 59 25 1 0.0109 1.000 1.000 360 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(8), AGXT2(8), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), ATP6V0C(1), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CPT1B(13), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), MAOA(5), MAOB(6), PEMT(2), PISD(5), PLCB2(10), PLCG1(17), PLCG2(23), PSPH(1), SARDH(15), SARS(5), SHMT1(6), SHMT2(5), TARS(7) 21297265 264 120 242 97 95 39 35 51 44 0 0.604 1.000 1.000 361 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(9), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(5), ADSSL1(6), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), ASRGL1(1), ASS1(4), CAD(20), CRAT(10), DARS(4), DARS2(7), DDO(6), DLAT(7), DLD(3), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), NARS2(8), PC(12), PDHA1(7), PDHA2(14), PDHB(3) 19177377 244 120 230 87 81 36 37 53 37 0 0.465 1.000 1.000 362 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(8), ABP1(4), ACADM(9), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), HIBCH(2), MLYCD(4), SMS(4), SRM(1), UPB1(7) 13882003 229 120 210 60 70 36 34 62 27 0 0.00838 1.000 1.000 363 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ATP6V0C(1), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADHA(10), PLOD1(7), PLOD2(9), PLOD3(6), SDS(3), SHMT1(6), SHMT2(5), TMLHE(3) 17869928 238 120 220 58 71 44 31 55 37 0 0.00204 1.000 1.000 364 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(30), ACAT1(7), ACAT2(8), ACYP1(1), ADH5(6), AKR1B1(3), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4) 18851796 268 120 241 83 78 55 36 58 41 0 0.138 1.000 1.000 365 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(26), GABBR1(16), GPRC5A(5), GPRC5B(3), GPRC5C(9), GPRC5D(3), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM7(30), GRM8(27) 10083260 224 119 193 88 92 30 27 44 31 0 0.620 1.000 1.000 366 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(23), C5(20), C6(24), C7(10), ICAM1(4), IL1A(1), IL6(5), IL8(5), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELP(13), SELPLG(16), TNF(1), VCAM1(12) 12743312 194 118 178 63 62 28 20 38 44 2 0.274 1.000 1.000 367 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(8), AGXT2(8), AKR1B10(3), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), GNMT(3), HSD3B7(3), MAOA(5), MAOB(6), PEMT(2), PHGDH(3), PIPOX(8), PISD(5), PSAT1(6), PSPH(1), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SARDH(15), SARS(5), SARS2(4), SDS(3), SHMT1(6), SHMT2(5), TARS(7), TARS2(9) 22029091 256 117 241 90 89 35 35 58 39 0 0.446 1.000 1.000 368 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(4), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GCNT1(7), GCNT3(4), GCNT4(12), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(5), WBSCR17(34) 16869914 242 117 232 93 87 32 31 56 36 0 0.815 1.000 1.000 369 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(10), POLA2(5), POLB(4), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLG(8), POLG2(4), POLH(13), POLI(22), POLK(9), POLM(11), POLQ(37), PRIM1(5), PRIM2(2), REV1(13), REV3L(36), RFC5(6) 21595347 262 117 236 78 55 46 32 68 60 1 0.434 1.000 1.000 370 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(16), CCNE1(6), CDC34(2), CDK2(5), CUL1(16), RB1(123), SKP2(3), TFDP1(10) 4612671 181 117 133 64 31 63 10 43 26 8 0.387 1.000 1.000 371 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(7), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A2(17), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH9A1(4), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), L2HGDH(3), OXCT1(3), PDHA1(7), PDHA2(14), PDHB(3), SDHB(3), SDS(3) 13503680 219 116 197 52 65 43 31 53 27 0 0.00116 1.000 1.000 372 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(3), B4GALT1(7), B4GALT2(7), G6PC(4), G6PC2(2), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANC(8), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), HSD3B7(3), LALBA(1), LCT(39), MGAM(26), PFKL(7), PFKM(2), PFKP(15), PGM1(8), PGM3(5), RDH11(3), RDH12(6), RDH13(4), RDH14(1), UGP2(10) 18749746 246 116 235 87 87 40 30 61 28 0 0.343 1.000 1.000 373 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(9), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CYP2C19(11), CYP2C9(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), HADHA(10), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3) 15799361 237 116 211 71 64 52 30 53 37 1 0.153 1.000 1.000 374 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(10), BIRC2(5), BIRC3(11), CASP3(3), CASP8(19), CFLAR(2), FADD(1), IKBKG(2), JUN(2), MAP2K4(32), MAP3K3(6), MAP3K7(7), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NR2C2(11), RALBP1(6), RIPK1(7), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 13007722 199 116 172 58 39 54 20 42 43 1 0.149 1.000 1.000 375 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), PON1(11) 14763894 222 115 217 66 85 37 21 53 25 1 0.0786 1.000 1.000 376 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(8), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSS(8), NADSYN1(4), PPAT(5), QARS(13) 17216991 223 115 205 54 58 49 29 61 26 0 0.00919 1.000 1.000 377 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(23), CREBBP(68), EP300(42), FADD(1), HDAC3(3), IKBKB(7), IKBKG(2), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 11517918 181 115 164 70 49 54 21 28 29 0 0.611 1.000 1.000 378 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(7), EGFR(104), ERBB3(28), NRG1(26), UBE2D1(1) 5466473 166 114 140 57 38 59 23 32 14 0 0.266 1.000 1.000 379 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(12), ACO1(11), ACO2(7), CLYBL(6), CS(2), DLD(3), DLST(3), FH(9), IDH1(18), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), OGDHL(12), PC(12), PCK1(3), PCK2(6), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1) 15450171 178 114 166 57 58 30 29 38 23 0 0.150 1.000 1.000 380 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(6), CDK2(5), CDKN1B(4), CKS1B(2), CUL1(16), RB1(123), SKP2(3), TFDP1(10), UBE2M(2) 4522685 171 114 125 60 26 61 10 37 29 8 0.473 1.000 1.000 381 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(23), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CHUK(23), CYCS(1), DFFA(4), DFFB(2), FADD(1), GAS2(4), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), SPTAN1(25), TNFRSF10A(8), TNFRSF10B(4), TNFRSF25(2), TNFSF10(2), TNFSF12(2), TRAF2(8) 17035165 201 113 179 68 44 46 23 46 41 1 0.558 1.000 1.000 382 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(12), AGT(10), AGTR1(12), AGTR2(15), CMA1(1), COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), REN(8) 13561363 191 112 182 59 47 28 25 51 40 0 0.0417 1.000 1.000 383 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(4), GRB2(9), HRAS(4), JAK2(48), JUN(2), MAP2K1(10), MAPK3(3), MAPK8(11), PLCG1(17), PTPN6(4), RAF1(13), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19) 11083947 190 112 154 67 47 56 19 32 33 3 0.736 1.000 1.000 384 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(7), B4GALT2(7), FBP2(4), G6PC(4), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANAB(12), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), LALBA(1), LCT(39), MGAM(26), PFKM(2), PFKP(15), PGM1(8), PGM3(5) 15965997 215 112 207 80 74 40 26 50 25 0 0.538 1.000 1.000 385 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ACY1(5), ADC(3), AGMAT(3), ALDH18A1(8), ALDH1A3(18), ALDH1B1(8), ALDH2(11), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), ASS1(4), CPS1(31), GATM(2), MAOA(5), MAOB(6), NAGS(5), ODC1(5), OTC(14), SAT1(4), SAT2(1), SMS(4), SRM(1) 15244572 203 112 180 60 60 47 27 46 23 0 0.0827 1.000 1.000 386 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(11), ALAS2(10), BLVRA(2), BLVRB(1), COX10(6), COX15(5), CP(18), CPOX(3), EARS2(3), EPRS(23), FECH(3), FTH1(1), FTMT(7), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), MMAB(1), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UROD(2), UROS(5) 21277127 250 112 225 63 57 47 32 62 52 0 0.0881 1.000 1.000 387 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), ABP1(4), AOC2(12), AOC3(9), CES1(13), DDHD1(39), ESCO1(16), ESCO2(13), LIPA(3), MYST3(28), MYST4(25), NAT6(2), PLA1A(8), PNPLA3(6), PPME1(2), PRDX6(4), SH3GLB1(5) 13135630 194 112 145 62 45 29 19 36 64 1 0.776 1.000 1.000 388 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREB1(3), CREBBP(68), EP300(42), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RARA(5), RXRA(8) 10639166 168 111 157 77 41 45 25 30 27 0 0.927 1.000 1.000 389 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(16), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GAPDHS(3), GCK(3), GOT1(6), GOT2(2), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6B(6), LDHB(5), LDHC(4), MDH1(8), MDH2(3), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PKLR(11), PKM2(4), TNFAIP1(4), TPI1(3) 21173327 249 111 229 100 93 43 24 54 35 0 0.779 1.000 1.000 390 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(7), ARG1(2), ARG2(5), ASL(3), ASS1(4), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), EPRS(23), GAMT(6), GATM(2), GLUD1(4), GLUD2(20), GOT1(6), GOT2(2), LAP3(3), NOS1(23), NOS3(21), OAT(3), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(5), RARS(7), RARS2(7) 17984900 226 111 210 70 73 34 34 51 34 0 0.205 1.000 1.000 391 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TAT(14), TPO(29) 11185665 183 111 157 49 78 27 18 33 27 0 0.0250 1.000 1.000 392 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), P4HB(6), SLC23A1(9), SLC23A2(17), SLC2A1(5), SLC2A3(12) 13422700 182 111 171 65 45 24 27 48 38 0 0.144 1.000 1.000 393 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(12), ACE2(12), AGT(10), AGTR1(12), AGTR2(15), ANPEP(16), CMA1(1), CPA3(4), CTSA(6), CTSG(4), ENPEP(22), LNPEP(21), MAS1(2), MME(23), NLN(10), REN(8), THOP1(6) 10823407 184 109 167 45 43 35 24 46 36 0 0.0201 1.000 1.000 394 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(23), IFNA1(7), IFNB1(6), IKBKB(7), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL1RN(6), IL6(5), IRAK1(6), IRAK2(11), IRAK3(9), JUN(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1), TOLLIP(5), TRAF6(4) 14938967 200 109 188 55 64 34 22 50 30 0 0.0732 1.000 1.000 395 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(4), FOS(4), GRB2(9), HRAS(4), IL2(4), IL2RA(3), IL2RB(4), IL2RG(8), JAK1(20), JAK3(27), JUN(2), LCK(8), MAP2K1(10), MAPK3(3), MAPK8(11), RAF1(13), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19), SYK(5) 11939753 197 109 161 54 51 46 21 35 43 1 0.171 1.000 1.000 396 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(12), ADCY1(22), CAP1(4), CCNB1(8), CDC25C(5), GNAI1(3), GNAS(35), GNB1(3), HRAS(4), MAPK1(3), MAPK3(3), MYT1(20), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RPS6KA1(9), SRC(3) 10031512 161 109 142 48 73 32 18 26 12 0 0.0282 1.000 1.000 397 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), NOS1(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), SYT1(14) 12815583 197 109 183 90 67 40 15 42 33 0 0.935 1.000 1.000 398 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(3), ALOX15(4), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(10), EPX(13), GGT1(9), LPO(9), LTA4H(2), MPO(13), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11), TPO(29) 14105216 195 109 179 63 78 27 24 36 30 0 0.187 1.000 1.000 399 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(11), DLG4(10), EPHB2(15), F2(9), F2RL1(7), F2RL2(6), JUN(2), MAP2K5(4), MAPK1(3), MAPK7(6), MAPK8(11), MYEF2(14), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RAF1(13), RASAL1(7), SRC(3), TEC(8), VAV1(22) 14119161 205 109 188 78 69 47 27 38 24 0 0.597 1.000 1.000 400 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CALM2(1), CALM3(1), CHUK(23), EGR2(14), EGR3(6), GNAQ(10), MAP3K1(18), MYC(5), NFATC2(10), NFKB1(8), NFKBIA(1), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), SYT1(14), VIP(3), VIPR2(11) 13428206 194 109 177 60 55 45 23 36 35 0 0.138 1.000 1.000 401 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(11), CD3D(4), CD3E(2), CD3G(15), CXCR3(4), ETV5(13), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), JAK2(48), JUN(2), MAP2K6(4), MAPK14(7), MAPK8(11), STAT4(10), TYK2(5) 9746274 177 108 146 69 29 56 23 38 29 2 0.831 1.000 1.000 402 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(15), EGF(7), EGFR(104), HGS(10), RAB5A(3), TF(16), TFRC(5) 6691469 160 107 137 63 29 59 22 32 17 1 0.434 1.000 1.000 403 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), AKR1B10(3), ALDOA(2), ALDOB(16), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), FUK(9), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), HSD3B7(3), KHK(4), LHPP(5), MPI(4), MTMR1(12), MTMR2(7), MTMR6(9), PFKFB1(12), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(7), PFKM(2), PFKP(15), PGM2(3), PHPT1(2), PMM1(3), PMM2(2), RDH11(3), RDH12(6), RDH13(4), RDH14(1), TPI1(3), TSTA3(1) 18801792 216 106 201 84 83 34 23 45 31 0 0.654 1.000 1.000 404 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(68), EP300(42), LPL(12), NCOA1(13), NCOA2(21), PPARG(4), RXRA(8) 9283947 168 106 157 77 40 47 27 32 22 0 0.910 1.000 1.000 405 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), DAG1(8), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFAT5(6), PDE6A(12), PDE6B(11), PDE6C(10), PDE6D(2), SLC6A13(9), TF(16) 17658234 238 106 234 84 75 43 28 51 41 0 0.328 1.000 1.000 406 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(3), NFYB(2), NFYC(10), RB1(123), SP1(6), SP3(10) 3561443 154 106 109 50 18 64 10 34 20 8 0.114 1.000 1.000 407 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 33 ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(2), ENPP7(2), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(5), SGMS2(6), SGPP1(6), SGPP2(4), SMPD1(9), SMPD2(3), SMPD3(4), SMPD4(8), SPHK1(2), SPHK2(5), SPTLC1(11), SPTLC2(9), UGCG(9), UGT8(10) 16365010 211 105 203 73 62 36 32 49 32 0 0.286 1.000 1.000 408 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(43), ARHGEF1(13), GNA12(6), GNA13(3), GNAQ(10), GNB1(3), MYL2(2), MYLK(29), PLCB1(22), PPP1R12B(28), PRKCA(5), ROCK1(27) 10928663 191 105 137 53 37 47 16 31 56 4 0.346 1.000 1.000 409 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(5), CASP2(8), CHUK(23), CRADD(3), IKBKB(7), IKBKG(2), JUN(2), LTA(1), MAP2K3(8), MAP2K4(32), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP4K2(5), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNF(1), TNFRSF1A(4), TRAF2(8) 12099962 185 105 169 60 49 42 25 37 31 1 0.218 1.000 1.000 410 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(1), BAX(14), BCL2(2), CASP8(19), CYCS(1), FADD(1), MAP2K1(10), MAP2K4(32), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFKB1(8), NSMAF(10), RAF1(13), RELA(9), RIPK1(7), SMPD1(9), TNFRSF1A(4), TRAF2(8) 10455578 183 104 156 47 52 32 23 34 40 2 0.0334 1.000 1.000 411 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(23), FADD(1), IKBKB(7), IKBKG(2), IL1A(1), IL1R1(6), IRAK1(6), MAP3K1(18), MAP3K14(6), MAP3K7(7), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TLR4(15), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 12143991 169 104 156 52 40 48 17 35 29 0 0.180 1.000 1.000 412 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(11), AZIN1(3), BTG1(2), CBX3(6), CLOCK(20), CRY1(13), CRY2(5), DNAJA1(4), EIF4G2(16), ETV6(10), GFRA1(12), GSTM3(5), GSTP1(1), HERPUD1(3), HSPA8(11), IDI1(4), KLF9(1), MYF6(6), NCKAP1(15), NCOA4(8), NR1D2(7), PER1(12), PER2(7), PIGF(1), PPP1R3C(4), PPP2CB(2), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(6), TUBB3(8), UCP3(3), UGP2(10), VAPA(2), ZFR(15) 18790421 238 103 199 68 68 37 22 53 56 2 0.334 1.000 1.000 413 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(7), ACAT2(8), ACOT11(9), ACYP1(1), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), FN3K(1), GCDH(6), HADHA(10), ITGB1BP3(1), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3) 13158598 178 103 161 60 47 35 23 38 34 1 0.477 1.000 1.000 414 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(5), ARSB(10), FUCA1(5), FUCA2(4), GALNS(6), GBA(4), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NAGLU(5), NEU1(6), NEU2(6), NEU3(2), SPAM1(9) 16510767 213 103 202 70 65 52 20 52 24 0 0.229 1.000 1.000 415 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(68), EP300(42), ESR1(20), MAPK1(3), MAPK3(3), PELP1(11), SRC(3) 7678049 150 103 140 68 40 38 19 29 24 0 0.920 1.000 1.000 416 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(48), JAK3(27), PIAS3(10), PTPRU(18), REG1A(6), SRC(3), STAT3(10) 7802819 156 103 131 56 45 51 22 19 17 2 0.491 1.000 1.000 417 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(12), EPHA4(20), EPHB1(33), FYN(15), ITGA1(12), ITGB1(12), L1CAM(14), LYN(13), RAP1B(2), SELP(13) 7982869 146 102 134 47 44 31 27 28 15 1 0.0971 1.000 1.000 418 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(8), CALCRL(7), CD97(10), CRHR1(4), CRHR2(5), ELTD1(11), EMR1(13), EMR2(7), GHRHR(2), GIPR(1), GLP1R(6), GLP2R(8), GPR64(17), LPHN1(19), LPHN2(26), LPHN3(26), SCTR(5), VIPR1(6), VIPR2(11) 13892229 196 102 192 84 61 31 19 60 25 0 0.849 1.000 1.000 419 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(7), CDK7(3), ERCC3(18), GTF2A2(1), GTF2B(11), GTF2E1(13), GTF2E2(1), GTF2H1(4), GTF2H4(3), ILK(3), MNAT1(3), POLR1A(12), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3B(8), POLR3D(5), POLR3E(10), POLR3H(2), POLR3K(1), TAF12(3), TAF13(3), TAF5(11), TAF6(8), TAF7(2), TAF9(2), TBP(2) 18321761 183 102 169 73 47 33 26 41 36 0 0.888 1.000 1.000 420 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(23), DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), LTA(1), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNFAIP3(39), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10) 11650534 171 102 153 52 44 50 18 26 33 0 0.102 1.000 1.000 421 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(13), FOS(4), GRB2(9), HRAS(4), IL3(6), JAK2(48), MAP2K1(10), MAPK3(3), PTPN6(4), RAF1(13), SHC1(13), SOS1(11), STAT5A(8), STAT5B(19) 8659347 165 101 129 52 41 52 15 24 30 3 0.449 1.000 1.000 422 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(9), ABAT(8), ADSL(13), ADSS(5), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), CAD(20), CRAT(10), DARS(4), DDO(6), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), PC(12) 13176927 167 100 155 58 55 22 26 41 23 0 0.425 1.000 1.000 423 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(10), ADRBK2(8), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CLCA1(12), CLCA2(8), CLCA4(14), CNGA3(14), CNGA4(13), CNGB1(15), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(2), PDC(4), PDE1C(17), PRKACA(1), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(10), PRKX(3) 16096741 196 100 190 91 56 30 28 50 32 0 0.960 1.000 1.000 424 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(11), BAIAP2(6), CASP1(6), CASP3(3), CASP7(3), CASP8(19), GAPDH(2), INSR(20), ITCH(7), MAGI1(27), MAGI2(25), RERE(15), WWP1(18), WWP2(8) 12050699 170 100 158 64 47 26 27 35 34 1 0.700 1.000 1.000 425 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 IL10RA(3), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(20), JAK2(48), JAK3(27), STAT1(15), STAT3(10), STAT5A(8), STAT5B(19), TYK2(5) 9227745 163 99 133 57 36 55 13 30 27 2 0.740 1.000 1.000 426 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), ESRRA(26), HDAC5(13), MEF2A(5), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(3), PPP3CB(10), PPP3CC(5), SLC2A4(7), SYT1(14), YWHAH(3) 10405264 157 99 126 65 42 30 11 30 44 0 0.961 1.000 1.000 427 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(7), CS(2), DLAT(7), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), PC(12), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PDK1(5), PDK2(8), PDK3(5), PDK4(4), PDP2(5), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1) 14714864 171 98 157 65 55 28 26 36 26 0 0.566 1.000 1.000 428 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(11), EEA1(15), GRASP(3), GSK3A(6), GSK3B(16), LYN(13), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PLCG1(17), PRKCE(4), PRKCZ(3), RAB5A(3), RAC1(2), RPS6KB1(9), VAV2(18) 12386375 172 98 156 51 52 37 25 28 29 1 0.117 1.000 1.000 429 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(9), F2R(11), GNAI1(3), GNB1(3), HRAS(4), ITGA1(12), ITGB1(12), MAP2K1(10), MAPK1(3), MAPK3(3), PLA2G4A(13), PLCB1(22), PRKCA(5), PTGS1(9), PTK2(24), RAF1(13), SRC(3), SYK(5), TBXAS1(11) 12718081 175 98 157 74 60 40 26 34 15 0 0.774 1.000 1.000 430 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(12), ITGB3(12), PTK2(24), PXN(2), RAC1(2), SPTAN1(25), SRC(3), TLN1(21) 14529895 165 98 159 88 52 30 19 40 22 2 0.998 1.000 1.000 431 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(4), CSF1R(15), DDX20(6), E2F4(2), ETS1(6), ETS2(4), ETV3(4), FOS(4), HDAC2(8), HDAC5(13), HRAS(4), JUN(2), NCOR2(38), RBL1(18), RBL2(22), SIN3A(20), SIN3B(9) 12922974 179 97 160 69 46 33 17 35 48 0 0.892 1.000 1.000 432 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(20), JAK2(48), JAK3(27), PIAS1(4), PIAS3(10), PTPRU(18), REG1A(6), SOAT1(6) 6928175 141 97 120 50 39 50 16 17 17 2 0.478 1.000 1.000 433 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(10), AKR1D1(8), ARSB(10), ARSD(9), ARSE(4), CYP11B1(13), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9) 14024603 178 96 160 50 64 28 20 29 37 0 0.0432 1.000 1.000 434 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(11), ACO2(7), CS(2), DLD(3), DLST(3), FH(9), IDH1(18), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), PC(12), PCK1(3), SDHA(12), SDHB(3), SUCLA2(6), SUCLG1(2), SUCLG2(1) 10611737 125 96 115 43 37 24 20 27 17 0 0.287 1.000 1.000 435 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C8B(22), C9(11), MASP1(19) 12608648 173 96 161 59 50 22 21 39 39 2 0.662 1.000 1.000 436 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5) 12636124 170 95 152 66 38 41 23 42 25 1 0.747 1.000 1.000 437 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(22), CALM2(1), CALM3(1), CAPN2(8), CAPNS1(4), CAPNS2(4), EP300(42), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(10), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SYT1(14) 11515991 145 95 132 65 39 31 21 26 28 0 0.911 1.000 1.000 438 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(23), DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), TNFAIP3(39), TRAF3(10), TRAF6(4) 9581523 148 94 133 41 37 42 14 25 30 0 0.0824 1.000 1.000 439 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(23), ARHGAP5(43), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(3), CASP8(19), CASP9(5), CYCS(1), GZMB(4), JUN(2), PRF1(7) 6744662 125 94 90 32 21 38 10 20 36 0 0.157 1.000 1.000 440 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG3(2), ATG5(9), ATG7(1), BECN1(2), GABARAPL1(1), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(9), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(25), PIK3R4(20), PRKAA1(8), PRKAA2(15), ULK2(14), ULK3(3) 10259623 156 94 138 41 23 41 23 46 22 1 0.0880 1.000 1.000 441 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(23), ARHGDIB(5), BIRC2(5), BIRC3(11), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), GZMB(4), LMNB1(9), LMNB2(2), PRF1(7) 9933116 134 93 116 51 24 32 11 36 31 0 0.902 1.000 1.000 442 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(5), DAB1(13), FYN(15), LRP8(1), RELN(83), VLDLR(13) 7325732 132 93 109 41 35 35 16 27 19 0 0.0713 1.000 1.000 443 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(66), MAP2(51), PPP1CA(2), PPP2CA(3), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4), PRKCE(4) 9497583 149 92 132 48 30 33 20 33 33 0 0.402 1.000 1.000 444 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(39), APOA1(3), APOA4(4), APOC2(1), APOE(1), CETP(11), CYP7A1(13), DGAT1(5), HMGCR(6), LCAT(4), LDLR(9), LIPC(5), LPL(12), LRP1(49), SCARB1(3), SOAT1(6) 13528722 171 92 161 64 55 29 23 43 21 0 0.571 1.000 1.000 445 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(9), CARS(10), DARS(4), EPRS(23), FARS2(5), GARS(8), HARS(6), IARS(9), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), NARS(4), QARS(13), RARS(7), SARS(5), TARS(7), WARS(3), WARS2(6), YARS(4) 17070398 165 91 160 36 54 23 25 40 23 0 0.0126 1.000 1.000 446 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(10), CHIT1(10), CMAS(6), CTBS(6), CYB5R1(2), CYB5R3(1), GFPT1(5), GFPT2(11), GNE(7), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NAGK(7), NANS(1), NPL(3), PGM3(5), PHPT1(2), RENBP(3), UAP1(6) 14792435 170 91 164 47 61 33 19 32 25 0 0.0594 1.000 1.000 447 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUD2(20), GLUL(4), HAL(11) 11111480 143 91 136 50 45 26 18 31 23 0 0.552 1.000 1.000 448 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(13), GLI2(22), GLI3(37), GSK3B(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SHH(3), SMO(11), SUFU(5) 7885736 140 91 129 62 54 30 13 21 22 0 0.725 1.000 1.000 449 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(22), GNAS(35), GNB1(3), PPP2CA(3), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 7641659 129 90 110 41 54 26 8 22 19 0 0.245 1.000 1.000 450 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11), MASP1(19), MASP2(10), MBL2(3) 12875350 164 90 153 60 45 18 21 38 40 2 0.820 1.000 1.000 451 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(18), GTF2A1(5), GTF2B(11), GTF2E1(13), GTF2F1(5), HDAC3(3), NCOA1(13), NCOA2(21), NCOA3(14), NCOR2(38), POLR2A(12), RARA(5), RXRA(8), TBP(2) 12246646 168 90 148 77 50 27 26 30 35 0 0.983 1.000 1.000 452 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(13), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPHN(16), NSF(4), SRC(3), UBQLN1(6) 6376004 134 88 124 46 33 20 14 43 24 0 0.468 1.000 1.000 453 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(7), AMD1(3), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTAP(2), MTFMT(1), MTR(13), SRM(1), TAT(14) 10647886 142 88 131 48 54 21 18 25 23 1 0.343 1.000 1.000 454 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(20), JAK2(48), JAK3(27), MAPK1(3), MAPK3(3), STAT3(10), TYK2(5) 5905510 116 88 93 42 27 50 9 17 11 2 0.658 1.000 1.000 455 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), BLVRB(1), CP(18), CPOX(3), EPRS(23), FECH(3), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UROD(2), UROS(5) 14137647 148 87 129 41 38 26 18 30 36 0 0.343 1.000 1.000 456 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 16 CALM2(1), CALM3(1), CDKN1A(2), GNAQ(10), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SP1(6), SP3(10), SYT1(14) 9788005 118 86 107 53 32 30 13 23 20 0 0.909 1.000 1.000 457 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(7), CARM1(3), CBS(3), CTH(5), GGT1(9), HEMK1(1), LCMT1(1), LCMT2(6), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), METTL2B(2), METTL6(5), PAPSS1(4), PAPSS2(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SCLY(11), SEPHS1(5), SEPHS2(5), WBSCR22(2) 12430794 140 86 132 44 37 23 19 34 27 0 0.258 1.000 1.000 458 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(9), SMPD2(3), SPTLC1(11), SPTLC2(9), UGCG(9) 11380855 154 85 146 52 45 27 21 42 19 0 0.317 1.000 1.000 459 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(16), ALDOC(1), DERA(4), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKL(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1(8), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TALDO1(4), TKT(6), TKTL1(7), TKTL2(12) 11909370 151 85 139 52 50 25 24 38 14 0 0.246 1.000 1.000 460 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(4), ALOX5(12), CYP1A2(10), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), HSD3B7(3), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 12588066 151 85 145 53 50 33 18 38 11 1 0.306 1.000 1.000 461 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(12), GLB1(9), HEXA(3), HEXB(3), LCT(39), SLC33A1(9), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7) 8467596 131 85 113 42 45 30 12 25 19 0 0.317 1.000 1.000 462 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(11), GRB2(9), IL2RG(8), IL4(5), IL4R(6), IRS1(17), JAK1(20), JAK3(27), RPS6KB1(9), SHC1(13), STAT6(4) 7166386 129 85 102 33 32 29 17 17 33 1 0.162 1.000 1.000 463 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(22), ADRB2(3), GNAS(35), PLCE1(32), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RAP2B(2) 7145289 119 85 102 30 49 28 7 23 12 0 0.0182 1.000 1.000 464 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(5), CSNK1D(14), DRD1(9), DRD2(7), GRM1(32), PLCB1(22), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 8141009 125 84 113 46 40 32 7 27 19 0 0.566 1.000 1.000 465 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOA(2), ALDOB(16), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), GCK(3), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), KHK(4), MPI(4), PFKFB1(12), PFKFB3(2), PFKFB4(5), PFKM(2), PFKP(15), PMM1(3), PMM2(2), TPI1(3) 12302833 139 84 128 55 51 23 14 31 20 0 0.685 1.000 1.000 466 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(16), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME3(7), PGK1(3), PGK2(9), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TKTL1(7), TKTL2(12), TPI1(3) 10247080 134 84 126 43 36 20 17 45 16 0 0.284 1.000 1.000 467 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(4), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), DDOST(4), DPAGT1(12), DPM1(3), FUT8(10), MAN1A1(12), MAN1B1(7), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), RPN1(4), RPN2(6), ST6GAL1(3) 9567334 136 84 122 43 39 29 17 27 24 0 0.499 1.000 1.000 468 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(11), CD2(7), CD3D(4), CD3E(2), CD3G(15), CD4(4), CXCR3(4), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), JAK2(48), STAT4(10), TYK2(5) 7738101 135 84 107 49 17 46 18 28 24 2 0.745 1.000 1.000 469 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(23), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP7(3), CASP8(19), CASP9(5), DFFA(4), DFFB(2), GZMB(4), PRF1(7), SCAP(6), SREBF1(8), SREBF2(9) 8877382 116 84 102 44 25 20 13 31 27 0 0.808 1.000 1.000 470 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(19), CR2(20), FCGR2B(2), HLA-DRA(11), HLA-DRB1(6), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27) 7448023 127 83 124 41 32 20 21 27 24 3 0.396 1.000 1.000 471 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(10), F13A1(12), F2(9), F2R(11), FGA(19), FGB(4), FGG(7), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8) 7190582 128 83 120 52 31 23 22 31 21 0 0.838 1.000 1.000 472 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(20), ABCC2(18), ABCG2(12), BCHE(25), CES1(13), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9) 12263034 158 83 136 52 42 29 23 33 30 1 0.323 1.000 1.000 473 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR7(5), CD28(4), CD4(4), CXCR3(4), CXCR4(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18R1(13), IL2(4), IL4(5), IL4R(6), TGFB1(2), TGFB2(6), TGFB3(2) 10650676 133 83 123 57 28 30 17 39 18 1 0.850 1.000 1.000 474 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(5), CREBBP(68), DFFA(4), DFFB(2), GZMA(8), GZMB(4), HMGB2(2), NME1(1), PRF1(7), SET(6) 5419971 108 83 103 46 29 25 14 23 17 0 0.796 1.000 1.000 475 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), XYLB(6) 13427435 161 82 145 42 31 26 19 43 42 0 0.281 1.000 1.000 476 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(16), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PGK1(3), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TPI1(3) 9122223 115 81 107 34 27 19 15 39 15 0 0.196 1.000 1.000 477 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(8), GALNT2(10), GALNT3(15), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GCNT1(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), WBSCR17(34) 7473393 113 81 109 42 50 17 14 13 19 0 0.464 1.000 1.000 478 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(16), ALDOC(1), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1(8), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TAL1(2), TALDO1(4), TKT(6) 10096770 123 81 111 43 39 22 16 35 11 0 0.367 1.000 1.000 479 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(5), IL13RA2(15), IL4R(6), JAK1(20), JAK2(48), TYK2(5) 5365235 101 81 81 35 19 50 3 19 8 2 0.495 1.000 1.000 480 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(5), IL13RA2(15), IL4R(6), JAK1(20), JAK2(48), TYK2(5) 5365235 101 81 81 35 19 50 3 19 8 2 0.495 1.000 1.000 481 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(22), ADRB2(3), CFTR(16), GNAS(35), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SLC9A3R1(3) 6371757 104 80 87 30 43 24 4 21 12 0 0.108 1.000 1.000 482 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(3), IFNGR1(6), JAK1(20), JAK2(48), PTPRU(18), REG1A(6), STAT1(15) 5980444 118 80 102 39 31 44 7 19 14 3 0.472 1.000 1.000 483 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(6), CHUK(23), IFNG(3), IKBKB(7), IL2(4), IL4(5), JUN(2), MAP3K1(18), MAP3K5(14), MAP4K5(4), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), TNFRSF9(9), TRAF2(8) 10072013 139 79 126 30 39 36 14 31 19 0 0.00818 1.000 1.000 484 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(16), CD2(7), CD33(2), CD5(7), CD7(4), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(16), TLR2(7), TLR4(15), TLR7(15), TLR9(12) 9572799 133 79 123 55 43 22 16 37 13 2 0.696 1.000 1.000 485 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), NAGLU(5), SPAM1(9) 10144481 141 79 130 44 43 33 12 36 17 0 0.228 1.000 1.000 486 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(23), MAP3K14(6), MAPK14(7), MAPK8(11), NFKB1(8), RELA(9), TNFRSF13B(6), TNFRSF17(4), TNFSF13(2), TNFSF13B(3), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4) 7337782 112 79 101 30 39 23 9 19 22 0 0.140 1.000 1.000 487 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), GLCE(5), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), NDST1(9), NDST2(9), NDST3(15), NDST4(13) 10448192 128 78 125 48 51 24 13 24 16 0 0.608 1.000 1.000 488 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(23), BAK1(2), BAX(14), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(5), BIRC3(11), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), DIABLO(3), ENDOG(3) 7082889 106 77 84 31 17 16 13 26 33 1 0.629 1.000 1.000 489 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), PECAM1(4), SELE(11), SELL(5), SELP(13) 8124736 115 77 115 36 38 22 12 23 20 0 0.215 1.000 1.000 490 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11) 9972928 120 77 113 45 36 23 17 23 21 0 0.712 1.000 1.000 491 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(3), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(5), EDN1(3), EDNRA(8), EDNRB(13), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(13), PRL(3), PTGDR(7), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11) 10734350 138 77 132 49 50 17 12 39 20 0 0.492 1.000 1.000 492 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2) 9737081 122 76 118 43 38 32 14 28 10 0 0.357 1.000 1.000 493 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(1), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), ILVBL(8), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7), VNN1(11) 8538602 128 76 121 34 28 26 23 37 13 1 0.0420 1.000 1.000 494 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(7), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTR(13) 9000806 121 76 114 38 45 20 13 21 21 1 0.276 1.000 1.000 495 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 AANAT(2), ACHE(3), CHAT(16), DBH(8), DDC(5), GAD1(15), GAD2(15), HDC(8), MAOA(5), PAH(15), PNMT(3), SLC18A3(11), TPH1(2) 6821903 108 75 100 45 37 18 11 34 8 0 0.649 1.000 1.000 496 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(8), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(14), JAK2(48), NFKB1(8), NFKBIA(1), RELA(9), SOD2(4) 6518410 102 75 89 37 19 39 12 17 13 2 0.488 1.000 1.000 497 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(18), AP2A1(5), AP2M1(6), BIN1(3), CALM2(1), CALM3(1), DNM1(13), EPN1(9), EPS15(11), NME1(1), PICALM(8), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYNJ1(24), SYNJ2(14), SYT1(14) 11587367 146 75 133 62 38 27 16 36 29 0 0.865 1.000 1.000 498 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11) 10836621 132 74 121 44 37 13 16 27 37 2 0.729 1.000 1.000 499 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(9), F2R(11), F3(1), F5(30), F7(6), FGA(19), FGB(4), FGG(7), PROC(3), PROS1(9), SERPINC1(8), TFPI(6) 8417194 118 74 110 46 31 24 17 32 14 0 0.738 1.000 1.000 500 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AGPS(5), CHPT1(3), ENPP2(23), ENPP6(10), PAFAH1B1(6), PAFAH2(6), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PPAP2A(2), PPAP2B(2), PPAP2C(3) 12152391 136 74 128 61 44 27 17 32 16 0 0.944 1.000 1.000 501 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(12), BST1(2), C9orf95(2), CD38(4), ENPP1(17), ENPP3(10), NADK(5), NADSYN1(4), NMNAT1(2), NMNAT2(4), NMNAT3(4), NNMT(4), NNT(5), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT12(3), QPRT(2) 11397771 123 73 117 42 37 26 16 29 14 1 0.219 1.000 1.000 502 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(6), FOS(4), GNAQ(10), JUN(2), MAPK14(7), MAPK8(11), PLCG1(17), PRKCA(5), PTK2B(13), SYT1(14) 7104158 105 72 95 46 21 27 9 31 17 0 0.953 1.000 1.000 503 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CMBL(1), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), PON1(11), PON2(6), PON3(10) 8728048 124 72 115 40 33 29 13 28 20 1 0.310 1.000 1.000 504 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(12), PGAP1(11), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGW(2), PIGX(2), PIGZ(6) 12374706 111 71 103 48 18 28 9 33 23 0 0.954 1.000 1.000 505 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5) 8323582 116 71 102 46 29 26 12 26 22 1 0.850 1.000 1.000 506 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(4), CSF1(4), CSF3(2), HLA-DRA(11), HLA-DRB1(6), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL11(6), IL12A(1), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), LTA(1), PDGFA(2), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1) 6675392 98 71 90 40 29 20 8 26 11 4 0.786 1.000 1.000 507 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(9), ACADS(3), ACADVL(6), ACSL1(9), ACSL3(11), ACSL4(10), CPT1A(10), CPT2(2), DCI(3), EHHADH(13), HADHA(10), SCP2(6), SLC25A20(1) 8818945 97 71 90 36 25 18 14 25 15 0 0.483 1.000 1.000 508 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), NCKAP1(15), NTRK1(16), PIR(1), PSMA7(1), RAC1(2), WASF1(3), WASF2(5), WASF3(14), WASL(16) 8126706 111 70 105 38 30 13 16 32 20 0 0.534 1.000 1.000 509 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(3), IFNGR1(6), IFNGR2(4), JAK1(20), JAK2(48), STAT1(15) 4405562 96 70 81 34 20 41 3 19 10 3 0.571 1.000 1.000 510 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(1), IARS(9), IARS2(19), ILVBL(8), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3), VARS(7), VARS2(9) 8561493 99 69 98 34 39 17 14 14 15 0 0.478 1.000 1.000 511 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2) 7949587 105 69 101 31 31 28 13 23 10 0 0.131 1.000 1.000 512 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(5), ALDH18A1(8), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), GAMT(6), GATM(2), GLUD1(4), NAGS(5), OAT(3), ODC1(5), OTC(14), SMS(4) 8948451 111 69 103 32 29 26 19 24 13 0 0.125 1.000 1.000 513 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(8), FOS(4), HRAS(4), JUN(2), MAP2K1(10), MAPK1(3), MAPK3(3), MYC(5), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RAF1(13), RELA(9), TNF(1) 7829244 98 68 88 38 30 18 19 17 14 0 0.528 1.000 1.000 514 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), CHST1(9), CHST2(11), CHST4(6), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 5473752 92 68 88 31 45 17 4 14 12 0 0.516 1.000 1.000 515 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(20), CLTA(5), CLTB(2), COPA(13), GBF1(17), GPLD1(12), KDELR1(5), KDELR2(8), KDELR3(2) 8562888 96 67 93 35 25 19 13 19 20 0 0.725 1.000 1.000 516 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(29), ABCB11(19), ABCB4(23), ABCC1(20), ABCC3(10), GSTP1(1) 7369488 102 67 105 33 18 16 16 27 23 2 0.536 1.000 1.000 517 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), FDXR(5), SHMT1(6) 8410255 103 67 88 39 31 24 12 17 19 0 0.717 1.000 1.000 518 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(7), CD28(4), CD3D(4), CD3E(2), CD3G(15), CD4(4), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27) 5825173 101 67 85 35 23 14 14 18 32 0 0.728 1.000 1.000 519 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(4), CD3D(4), CD3E(2), CD3G(15), IFNG(3), IL2(4), IL2RA(3), IL4(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14), TOB1(6), TOB2(2) 5631073 113 67 88 36 34 24 11 18 26 0 0.457 1.000 1.000 520 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(23), C5(20), C6(24), C7(10), C8A(11), C9(11) 6634264 99 66 91 32 30 11 13 22 22 1 0.456 1.000 1.000 521 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6) 8056795 98 66 83 38 30 23 12 15 18 0 0.755 1.000 1.000 522 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(11), ERBB4(56), NRG2(6), NRG3(14), PRKCA(5), PSEN1(3) 4774191 95 66 88 36 17 21 18 25 14 0 0.678 1.000 1.000 523 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6) 8056795 98 66 83 38 30 23 12 15 18 0 0.755 1.000 1.000 524 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(7), CD28(4), CD3D(4), CD3E(2), CD3G(15), CD8A(1), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27) 5481124 98 66 82 33 24 14 12 17 31 0 0.674 1.000 1.000 525 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B1(15), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6) 8056795 98 66 83 38 30 23 12 15 18 0 0.755 1.000 1.000 526 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), IDS(5), LCT(39), NAGLU(5) 7169816 92 65 86 30 34 19 8 22 9 0 0.218 1.000 1.000 527 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), PECAM1(4), SELE(11), SELL(5) 6246027 89 65 87 32 26 18 8 18 19 0 0.554 1.000 1.000 528 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(20), ESR2(8), ITPKA(3), PDE1A(8), PDE1B(10), PLCB1(22), PLCB2(10), PRL(3), TRH(7), VIP(3) 5653105 94 65 87 34 27 17 13 21 16 0 0.561 1.000 1.000 529 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(13), KHK(4), LCT(39), MPI(4), PGM1(8), PYGL(6), PYGM(10), TPI1(3), TREH(6) 6970708 93 64 87 29 26 20 15 26 6 0 0.155 1.000 1.000 530 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), PHPT1(2), RFK(1), TYR(9) 7930988 108 64 97 31 30 29 12 20 16 1 0.160 1.000 1.000 531 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1) 12162862 101 64 98 28 28 15 22 20 16 0 0.158 1.000 1.000 532 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(12), APAF1(23), BCL2(2), CASP3(3), CASP9(5), CYCS(1), DAXX(14), FAS(7), FASLG(3), HSPB2(2), IL1A(1), MAPKAPK2(4), MAPKAPK3(6), TNF(1) 5583459 84 64 70 36 17 22 11 13 21 0 0.926 1.000 1.000 533 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(4), CD86(2), HLA-DRA(11), HLA-DRB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), IL2(4), IL2RA(3), IL4(5), IL4R(6) 6456954 92 64 85 31 21 19 11 24 13 4 0.430 1.000 1.000 534 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(35), GNB1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5) 4744985 72 63 58 30 32 18 2 10 10 0 0.661 1.000 1.000 535 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(3), ALOX15(4), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(2), GGT1(9), LTA4H(2), PLA2G6(8), PTGDS(2), PTGES(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11) 7445767 90 63 84 35 28 11 12 21 18 0 0.683 1.000 1.000 536 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 64 FAU(1), MRPL13(6), MRPS7(4), RPL10A(2), RPL10L(4), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(2), RPL7(3), RPL8(3), RPL9(3), RPS10(2), RPS11(2), RPS13(2), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS5(2), RPS6(2), RPS7(1), RPS9(3), RPSA(1) 10355172 103 63 99 28 27 23 16 24 13 0 0.220 1.000 1.000 537 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(30), CPT1A(10), LEP(1), LEPR(15), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6) 7781487 97 63 94 28 29 9 11 31 17 0 0.426 1.000 1.000 538 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37) 8638137 106 62 93 33 34 13 17 27 15 0 0.324 1.000 1.000 539 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(2), ATIC(13), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4) 9719681 94 62 88 45 29 14 14 19 16 2 0.951 1.000 1.000 540 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(2), BNIP1(5), GOSR1(4), GOSR2(5), SEC22B(3), SNAP23(2), SNAP25(1), SNAP29(4), STX11(6), STX12(6), STX16(7), STX17(1), STX18(2), STX19(3), STX2(5), STX3(3), STX4(3), STX5(10), STX6(2), STX7(3), STX8(5), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(3), VAMP4(3), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1) 8341316 108 62 96 31 34 11 11 22 30 0 0.435 1.000 1.000 541 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(6), B3GAT2(1), B3GAT3(1), B4GALT7(2), CHPF(10), CHST11(4), CHST12(4), CHST14(1), CHST3(6), CHSY1(14), DSE(9), UST(10), XYLT1(12), XYLT2(15) 6473794 95 61 78 42 35 13 12 16 18 1 0.889 1.000 1.000 542 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(9), CYSLTR2(16), GPR109B(5), GPR161(10), GPR171(10), GPR18(3), GPR34(10), GPR39(3), GPR45(11), GPR65(1), GPR68(5), GPR75(9) 5126755 92 60 79 38 24 21 6 24 16 1 0.890 1.000 1.000 543 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(5), FDFT1(3), FDPS(6), GGCX(8), GGPS1(4), HMGCR(6), IDI1(4), IDI2(3), LSS(4), MVD(3), MVK(16), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1), TM7SF2(2) 9743490 96 60 85 33 27 8 13 23 25 0 0.764 1.000 1.000 544 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(15), PSMD11(8), PSMD12(4), PSMD13(6), PSMD2(3), PSMD6(5) 8627918 81 59 76 36 20 21 11 18 11 0 0.897 1.000 1.000 545 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(2), ATIC(13), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4) 9430955 89 59 82 43 26 15 13 18 15 2 0.949 1.000 1.000 546 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(10), FOS(4), JUN(2), MAPK3(3), OPRK1(12), POLR2A(12), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 6640353 71 58 68 19 26 13 5 12 15 0 0.155 1.000 1.000 547 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2) 7099195 77 58 77 30 15 19 8 24 11 0 0.782 1.000 1.000 548 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9) 8920638 89 58 75 27 25 13 11 12 28 0 0.538 1.000 1.000 549 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(7), IFNB1(6), JAK1(20), PTPRU(18), REG1A(6), STAT1(15), STAT2(10), TYK2(5) 6410913 87 58 81 21 30 20 8 16 13 0 0.0846 1.000 1.000 550 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(6), CYB5R3(1), GCK(3), GFPT1(5), GNE(7), GNPDA1(2), GNPDA2(3), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), PGM3(5), RENBP(3), UAP1(6) 8750177 83 57 80 29 26 21 8 17 11 0 0.525 1.000 1.000 551 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CALM3(1), CAMK1(7), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CAMKK1(2), CAMKK2(8), CREB1(3), SYT1(14) 5920553 73 56 65 36 20 19 7 14 13 0 0.941 1.000 1.000 552 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), CYP21A2(9), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3) 4482032 71 55 59 26 29 11 6 10 15 0 0.687 1.000 1.000 553 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL15(1), IL16(14), IL18(3), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL8(5), IL9(1), LTA(1), TNF(1) 5013721 68 55 61 36 20 15 6 20 7 0 0.931 1.000 1.000 554 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(16), ENO1(3), GPI(5), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(11), TPI1(3) 4387834 65 55 58 25 21 12 5 20 7 0 0.697 1.000 1.000 555 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), CYP21A2(9), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3) 4482032 71 55 59 26 29 11 6 10 15 0 0.687 1.000 1.000 556 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), NAT1(1), NAT2(3), XDH(19) 4269526 68 55 64 30 22 13 9 18 6 0 0.832 1.000 1.000 557 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), NTAN1(10), SIRT1(7), SIRT2(2), SIRT5(2), SIRT7(3), VNN2(4) 6144947 67 55 60 20 21 9 9 11 17 0 0.392 1.000 1.000 558 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(10), NEK1(20), WEE1(15) 3702607 72 55 61 23 11 18 5 19 18 1 0.722 1.000 1.000 559 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(12), CD38(4), ENPP1(17), ENPP3(10), NADSYN1(4), NMNAT1(2), NMNAT2(4), NNMT(4), NNT(5), NT5C(1), NT5E(6), NT5M(3), QPRT(2) 7785195 74 54 68 23 21 18 9 17 8 1 0.146 1.000 1.000 560 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(10), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(2), CDK5R1(5), CSNK1A1(3), CSNK1D(14), GSK3B(16), MAPT(10), PPP2CA(3) 4347482 73 54 70 23 25 17 5 16 10 0 0.357 1.000 1.000 561 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), EPO(1), FLT3(27), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(6), TGFB3(2) 4375309 68 53 62 34 18 17 4 18 10 1 0.964 1.000 1.000 562 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(6), IL10(1), IL10RA(3), IL10RB(6), IL1A(1), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(8), TNF(1) 6253500 79 53 70 31 25 14 6 19 15 0 0.755 1.000 1.000 563 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(13), ADSS(5), DHFR(1), HPRT1(2), IMPDH1(3), MTHFD2(2), POLB(4), POLD1(18), POLG(8), PRPS2(6), RRM1(2), SRM(1) 6276418 65 53 63 26 24 6 10 12 13 0 0.729 1.000 1.000 564 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(4), FOSL1(1), FOSL2(4), IFNAR1(7), IFNAR2(3), IFNB1(6), MAPK8(11), NFKB1(8), RELA(9), TNFRSF11A(5), TNFSF11(8), TRAF6(4) 5597305 70 53 68 24 19 15 9 12 15 0 0.410 1.000 1.000 565 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(16), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(2), CDK2(5), CDK4(3), CDKN1B(4), CDKN2A(7), E2F2(7), E2F4(2), PRB1(3) 4415905 61 53 57 23 13 12 9 18 9 0 0.595 1.000 1.000 566 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(16), CKM(6), FBL(6), GPT(6), LDHA(10), LDHB(5), LDHC(4), MAPK14(7), NCL(10) 4545633 70 53 63 27 17 16 10 20 7 0 0.634 1.000 1.000 567 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(10), GNB1(3), HTR2C(13), PLCB1(22), TUB(13) 3723592 65 53 64 26 26 12 7 15 5 0 0.654 1.000 1.000 568 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2) 7032103 68 51 70 32 14 16 7 20 11 0 0.966 1.000 1.000 569 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CSK(3), GRB2(9), PRKCA(5), PTPRA(5), SRC(3) 4794667 60 51 56 23 14 19 5 17 5 0 0.602 1.000 1.000 570 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(6), UBE2A(4), UBE3A(19) 6949809 72 50 69 29 18 16 10 16 12 0 0.740 1.000 1.000 571 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(6), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10) 4818345 67 48 66 22 19 9 7 22 10 0 0.494 1.000 1.000 572 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(6), FARSB(11), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4), YARS2(6) 4613164 69 48 63 21 18 8 10 22 11 0 0.393 1.000 1.000 573 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), IMPA2(3), ISYNA1(6), PGM1(8), PGM3(5) 5688831 65 48 62 31 23 11 7 16 8 0 0.858 1.000 1.000 574 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(6), B3GALNT1(5), B3GALT5(3), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST8SIA1(10) 5160355 71 48 69 23 23 8 8 22 10 0 0.435 1.000 1.000 575 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 3915509 58 47 53 17 23 13 3 11 8 0 0.429 1.000 1.000 576 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(10), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RELA(9) 4316122 55 47 52 21 15 12 7 13 8 0 0.662 1.000 1.000 577 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(12), CD44(5), CSF1(4), FCGR3A(4), IL1B(4), IL6R(7), SELL(5), SPN(4), TGFB1(2), TGFB2(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(7), TNFSF8(4) 6662233 70 47 69 21 22 8 12 16 12 0 0.211 1.000 1.000 578 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(7), CAMK1G(5), HDAC9(18), MEF2A(5), MEF2C(15), MEF2D(3), YWHAH(3) 3739887 56 46 61 29 21 8 2 17 7 1 0.964 1.000 1.000 579 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(16), CHKA(4), PCYT1A(4), PDHA1(7), PDHA2(14), PEMT(2), SLC18A3(11) 3473981 61 45 60 36 26 9 10 11 5 0 0.942 1.000 1.000 580 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(5), B3GALT1(3), B3GALT2(10), B3GALT5(3), B3GNT5(3), FUT1(8), FUT2(6), FUT3(4), ST3GAL3(12), ST3GAL4(4) 3540206 58 45 55 22 26 6 3 14 9 0 0.706 1.000 1.000 581 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(25), GNA12(6), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4) 5350557 54 44 52 15 13 8 7 15 11 0 0.354 1.000 1.000 582 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13) 6380793 63 44 61 19 22 12 7 12 10 0 0.430 1.000 1.000 583 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), HMGCS1(1), IDI1(4), LSS(4), MVD(3), MVK(16), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1) 6601604 64 43 54 20 18 7 7 15 17 0 0.617 1.000 1.000 584 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(2), ENO3(5), FARS2(5), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4) 4455212 56 42 51 24 13 7 12 17 7 0 0.840 1.000 1.000 585 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), PGM1(8), PGM3(5) 5185687 56 41 53 27 19 10 6 15 6 0 0.879 1.000 1.000 586 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(9), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3) 5306104 55 41 55 23 17 11 9 10 8 0 0.786 1.000 1.000 587 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12), XYLT2(15) 3013566 44 40 33 22 15 7 2 6 13 1 0.985 1.000 1.000 588 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12), XYLT2(15) 3013566 44 40 33 22 15 7 2 6 13 1 0.985 1.000 1.000 589 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NFS1(5), PHPT1(2), THTPA(2), TPK1(5) 3347996 47 40 43 14 14 12 5 8 8 0 0.393 1.000 1.000 590 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(12), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(5), APOBEC3F(1), APOBEC3G(6), APOBEC4(7) 3914814 48 38 47 15 19 4 9 8 8 0 0.365 1.000 1.000 591 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(9), MBTPS1(11), MBTPS2(2), SCAP(6), SREBF1(8), SREBF2(9) 5502059 46 38 45 25 13 10 8 8 7 0 0.884 1.000 1.000 592 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(3), FOS(4), FYN(15), JUN(2), MAPK14(7), THBS1(12) 3778936 46 37 42 17 12 7 6 8 13 0 0.533 1.000 1.000 593 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(12), AOC3(9), CES1(13), ESD(4) 2998414 42 36 41 17 15 6 6 10 5 0 0.624 1.000 1.000 594 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 13 BPNT1(9), CHST11(4), CHST12(4), PAPSS1(4), PAPSS2(5), SULT1A1(4), SULT1A2(4), SULT1E1(5), SULT2A1(4), SULT2B1(4), SUOX(5) 4883015 52 36 49 18 17 8 5 14 8 0 0.565 1.000 1.000 595 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(3), FOS(4), JUN(2), KEAP1(5), MAPK1(3), MAPK14(7), MAPK8(11), NFE2L2(4), PRKCA(5) 4239099 44 35 44 21 8 9 4 16 7 0 0.925 1.000 1.000 596 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(9), NR1H3(16), NR1H4(7), RXRA(8) 2597155 42 34 35 20 11 8 6 6 11 0 0.939 1.000 1.000 597 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(8), F13B(10), HSD17B1(2), HSD17B2(6), HSD17B3(4), HSD17B4(9), HSD3B1(5), HSD3B2(3) 4242355 47 34 45 19 16 10 7 9 5 0 0.524 1.000 1.000 598 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(5), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), ST3GAL3(12) 2030097 39 32 37 18 21 5 2 8 3 0 0.756 1.000 1.000 599 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(6), PLCG1(17), PRKCA(5), PTK2B(13) 3447846 41 32 39 23 11 11 5 8 6 0 0.974 1.000 1.000 600 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(10), CYP2E1(9), NR1I3(3), PTGS1(9), PTGS2(9) 2793524 40 31 40 15 18 4 8 7 3 0 0.605 1.000 1.000 601 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(8), CYP11A1(5), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3) 3506464 39 31 38 23 17 6 6 5 5 0 0.913 1.000 1.000 602 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(11), ALAS2(10), CPOX(3), FECH(3), HMBS(4), PPOX(5), UROD(2), UROS(5) 4051107 43 31 39 11 17 7 5 8 6 0 0.360 1.000 1.000 603 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(6), GOT2(2), TAT(14), TYR(9) 2521444 36 31 30 18 10 5 9 10 2 0 0.865 1.000 1.000 604 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(8), GAD1(15), HDC(8), PNMT(3), TPH1(2) 2671897 36 30 34 17 11 6 2 13 4 0 0.862 1.000 1.000 605 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMB8(6), PSMB9(4) 4401070 37 30 36 19 9 5 5 10 8 0 0.929 1.000 1.000 606 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(9), ACADS(3), ACAT1(7), ECHS1(3), HADHA(10) 2793555 36 29 36 15 9 6 5 7 9 0 0.713 1.000 1.000 607 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), DHFR(1), FPGS(4), GGH(1), SPR(7) 2772845 35 29 34 14 11 7 5 8 4 0 0.598 1.000 1.000 608 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(7), ACAT2(8), BDH1(3), BDH2(2), HMGCS1(1), HMGCS2(5), OXCT1(3), OXCT2(3) 3844184 32 29 30 11 10 6 3 6 7 0 0.590 1.000 1.000 609 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(7), CSF1(4), IL6(5), LDLR(9), LPL(12) 2735901 37 29 35 18 10 11 3 7 6 0 0.796 1.000 1.000 610 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(12), NR3C1(8), PPARG(4), RETN(2), RXRA(8), TNF(1) 2821698 37 29 35 23 10 5 8 8 6 0 0.972 1.000 1.000 611 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(9), PRKCA(5), TGM2(15) 2559717 34 27 33 19 13 6 3 9 3 0 0.904 1.000 1.000 612 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(7), ARG1(2), GLS(2), GLUD1(4), OAT(3), PRODH(5) 2793487 23 22 22 10 10 6 2 1 4 0 0.668 1.000 1.000 613 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(2), TAT(14) 1417414 22 20 17 11 7 1 7 5 2 0 0.839 1.000 1.000 614 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(9), SNAP25(1), STX1A(3), VAMP2(1) 1689745 18 18 16 10 7 4 3 3 1 0 0.943 1.000 1.000 615 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(6), IFNG(3), IL12A(1), IL12B(1), IL18(3), IL2(4) 1606799 18 14 17 14 1 4 5 6 2 0 0.989 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 273768 1 1 1 2 1 0 0 0 0 0 0.955 1.000 1.000