rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(8), LIPT1(11) 821172 19 17 14 0 0 3 2 3 11 0 0.0552 0.146 1.000 2 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(7) 384581 7 8 7 1 6 0 0 1 0 0 0.331 0.369 1.000 3 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(5), TPI1(3) 802771 8 8 8 1 0 0 1 7 0 0 0.397 0.709 1.000 4 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(7), DCN(7), FMOD(8), KERA(7), LUM(12) 1873748 41 36 40 9 10 12 1 14 4 0 0.212 0.817 1.000 5 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 6 ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4) 3071928 58 44 52 9 19 9 7 15 8 0 0.0105 0.856 1.000 6 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 6 ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4) 3071928 58 44 52 9 19 9 7 15 8 0 0.0105 0.856 1.000 7 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(4), CD4(4), HLA-DRB1(6) 912125 14 12 13 7 1 0 2 5 4 2 0.963 0.860 1.000 8 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 5 BAAT(3), CDO1(3), CSAD(4), GAD1(15), GAD2(15) 2490512 40 36 33 8 16 6 4 11 3 0 0.0702 0.936 1.000 9 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(3), CASP8(19), CFL1(2), CFLAR(2), PDE6D(2) 1974946 30 28 28 5 5 2 3 8 12 0 0.194 0.952 1.000 10 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), IL8(5), SLPI(2) 832960 16 15 15 7 2 3 2 3 6 0 0.794 0.958 1.000 11 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPX1(4), PRKCE(4) 3921206 100 77 93 24 25 15 11 33 16 0 0.0327 0.961 1.000 12 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 4 ALDH6A1(5), ALDOA(2), ALDOC(1), TPI1(3) 1518887 11 11 11 1 2 0 1 8 0 0 0.198 0.962 1.000 13 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 10 ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), SDS(3) 5250902 87 63 80 14 27 12 13 21 14 0 0.00171 0.963 1.000 14 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(5), B3GNT1(5), FUT1(8), FUT2(6), FUT9(9), GCNT2(24), ST8SIA1(10) 2877199 67 53 62 17 20 8 8 22 8 1 0.0941 0.976 1.000 15 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(7), ACAT2(8), ACYP1(1), ECHS1(3), EHHADH(13), GCDH(6), HADHA(10), SDHB(3), SDS(3) 4069262 54 43 51 9 14 8 9 12 11 0 0.0190 0.976 1.000 16 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 2 BMP1(17), BMPR1B(14) 1523595 31 26 30 7 11 4 2 7 7 0 0.337 0.978 1.000 17 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(3), GSTZ1(4), HGD(5) 1190363 12 10 11 3 0 1 5 4 2 0 0.300 0.986 1.000 18 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), HLCS(12), SPCS1(2), SPCS3(2) 1621531 21 18 19 5 8 3 1 6 3 0 0.213 0.993 1.000 19 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 2 CD3D(4), CD3E(2) 428871 6 6 4 3 0 4 1 0 1 0 0.751 0.993 1.000 20 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 3 ALDH1A1(11), BCMO1(5), RDH5(2) 1472552 18 16 18 6 3 4 2 6 3 0 0.615 0.998 1.000 21 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(3), EHHADH(13), HADHA(10), SDS(3) 2543336 29 26 28 7 8 3 6 6 6 0 0.205 0.999 1.000 22 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 8 ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), MIOX(3), UGDH(8) 3803280 64 49 56 13 19 11 7 13 14 0 0.0818 0.999 1.000 23 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(7), ACAA2(2), ACAT1(7), ACAT2(8), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), SDS(3) 4429277 62 51 59 13 13 12 12 13 12 0 0.0329 0.999 1.000 24 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(5), CBS(3), CTH(5), MUT(7) 2444165 23 19 23 4 9 1 6 3 4 0 0.0855 1.000 1.000 25 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CCR5(11), CD28(4), CD3D(4), CD3E(2), CD4(4) 1572475 25 23 22 8 3 4 5 8 5 0 0.541 1.000 1.000 26 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP1(6), RANBP2(24), RANGAP1(4) 4139507 36 31 34 4 7 6 5 10 8 0 0.0208 1.000 1.000 27 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(11), ACO2(7), FH(9), IDH2(16), MDH1(8), MDH2(3), SDHB(3), SUCLA2(6) 4267223 63 57 57 13 13 12 9 18 11 0 0.0454 1.000 1.000 28 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(2), FOSB(6), GRIA2(23), PPP1R1B(1) 1746011 32 28 32 11 13 5 3 8 3 0 0.380 1.000 1.000 29 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(11), CYP2C9(8) 1088534 19 19 18 5 2 7 2 7 1 0 0.431 1.000 1.000 30 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(5), ST6GALNAC4(3), ST8SIA1(10) 2831569 31 28 29 7 10 7 3 5 6 0 0.159 1.000 1.000 31 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 7 ACE(12), AGT(10), AGTR1(12), BDKRB2(4), KNG1(8), NOS3(21), REN(8) 4146324 75 50 68 13 20 6 11 17 21 0 0.0185 1.000 1.000 32 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(1), CSF1(4), CSF3(2), EPO(1), IL11(6), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), IL9(1) 3217023 47 38 44 13 14 11 4 13 4 1 0.219 1.000 1.000 33 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(4), GALT(3), UGDH(8), UGP2(10), UXS1(8) 2598375 33 30 33 7 8 1 6 8 10 0 0.416 1.000 1.000 34 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(1), CCR3(9), CD4(4), HLA-DRB1(6), IL1B(4), IL4(5), IL5RA(9), IL6(5) 2510259 43 27 40 13 13 6 5 14 3 2 0.392 1.000 1.000 35 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(12), PDXK(1), PDXP(1), PNPO(2), PSAT1(6) 2535314 22 21 21 6 6 7 3 3 3 0 0.298 1.000 1.000 36 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(12), ACO1(11), ACO2(7), ACSS1(6), ACSS2(9), FH(9), IDH2(16), MDH1(8), MDH2(3), SUCLA2(6) 6547981 87 69 80 16 23 16 12 23 13 0 0.00504 1.000 1.000 37 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 2460399 25 23 22 6 10 4 1 7 3 0 0.289 1.000 1.000 38 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(12), RAB11A(3), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(3), RAB6A(4), RAB9A(2) 2211388 37 30 35 11 12 5 8 5 7 0 0.276 1.000 1.000 39 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(8), SUCLA2(6) 1061048 14 13 14 6 8 1 3 0 2 0 0.643 1.000 1.000 40 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 4 ARNTL(11), CRY2(5), CSNK1E(9), PER1(12) 2731395 37 29 35 7 16 6 1 12 2 0 0.0931 1.000 1.000 41 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(4), GALT(3), UGDH(8), UXS1(8) 2029445 23 22 23 6 6 1 4 5 7 0 0.606 1.000 1.000 42 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(7), ERBB3(28), NRG1(26), UBE2D1(1) 4069263 62 50 51 12 20 15 7 10 10 0 0.0518 1.000 1.000 43 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(4), IL1B(4), MST1(5), MST1R(14), TNF(1) 2643030 28 25 25 7 9 4 4 8 3 0 0.198 1.000 1.000 44 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(9), PAPSS1(4), PAPSS2(5), SULT1A2(4), SULT1E1(5), SULT2A1(4), SUOX(5) 3569533 36 26 33 7 11 5 4 9 7 0 0.172 1.000 1.000 45 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(4), PGLYRP2(7) 910750 11 10 11 6 4 1 2 3 1 0 0.851 1.000 1.000 46 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 8 BIRC3(11), CASP8(19), FADD(1), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 3519536 52 43 44 14 10 14 3 9 16 0 0.217 1.000 1.000 47 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(7), ACOX1(11), ACOX3(8), ELOVL2(9), ELOVL5(3), ELOVL6(3), FADS2(10), HADHA(10), HSD17B12(3), SCD(4) 5597538 68 53 65 11 22 8 10 17 11 0 0.00393 1.000 1.000 48 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(7), ACAT2(8), OXCT1(3) 1813873 18 16 16 8 2 5 3 4 4 0 0.827 1.000 1.000 49 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(11), KARS(8) 2561211 22 19 21 5 4 1 5 8 4 0 0.429 1.000 1.000 50 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH2(16), MGST1(2), MGST2(2), MGST3(1), PGD(7) 8296731 130 78 121 26 31 20 22 41 16 0 0.00205 1.000 1.000 51 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 4 ATP6V0C(1), GBA3(3), SHMT1(6), SHMT2(5) 1517134 15 15 18 7 6 1 2 2 4 0 0.830 1.000 1.000 52 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8) 2941977 39 35 36 13 5 13 6 13 2 0 0.359 1.000 1.000 53 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 3 GLS(2), GLS2(6), GLUD1(4) 1771605 12 12 12 4 5 3 0 3 1 0 0.611 1.000 1.000 54 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(13), GBA(4), GBA3(3), LPO(9), MPO(13), PRDX6(4), TPO(29) 4183716 75 58 69 18 37 11 5 11 11 0 0.0736 1.000 1.000 55 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(3), FDPS(6), IDI1(4), SQLE(1) 1611811 14 14 14 5 1 2 3 4 4 0 0.715 1.000 1.000 56 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNG(3), IFNGR1(6), IFNGR2(4), JAK1(20), STAT1(15) 3152891 48 37 44 13 14 11 0 13 9 1 0.416 1.000 1.000 57 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(5), CDK7(3), MNAT1(3), SHH(3), XPO1(7) 4537450 58 46 56 13 15 11 8 19 5 0 0.0951 1.000 1.000 58 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(3), FDPS(6), GGPS1(4), IDI1(4), IDI2(3), SQLE(1) 2198213 21 21 20 6 4 2 3 5 7 0 0.562 1.000 1.000 59 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7) 6799094 108 67 101 25 18 22 20 34 13 1 0.0238 1.000 1.000 60 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 4 ACACA(30), ACACB(37), MCAT(3), OXSM(10) 6119185 80 50 78 15 28 11 15 18 8 0 0.0122 1.000 1.000 61 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(12), PARK2(11), SNCA(2), SNCAIP(6), UBE2E2(3), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5) 3325112 45 35 44 13 13 2 9 14 7 0 0.286 1.000 1.000 62 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 IL13(2), IL4(5), MAF(9), MAP2K3(8), MAPK14(7), NFATC2(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 4691769 66 55 66 18 29 11 6 12 8 0 0.0738 1.000 1.000 63 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(11), DLL1(6), FURIN(14), PSEN1(3) 2426914 34 27 34 11 11 5 5 7 6 0 0.336 1.000 1.000 64 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 ABO(5), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GCNT2(24), ST3GAL6(12), ST8SIA1(10) 6934431 120 82 112 28 40 18 10 34 17 1 0.0354 1.000 1.000 65 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(1), COQ5(2), COQ6(2), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1) 2135214 16 16 18 6 6 1 6 1 2 0 0.570 1.000 1.000 66 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(6), MMP2(12), MMP9(14), RECK(12), TIMP1(1), TIMP2(3), TIMP3(10), TIMP4(4) 3887906 66 50 63 19 33 11 5 11 6 0 0.146 1.000 1.000 67 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), KARS(8) 3769147 42 35 39 11 8 5 6 15 8 0 0.433 1.000 1.000 68 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 14 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4) 6346984 98 71 88 28 26 22 14 25 11 0 0.127 1.000 1.000 69 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 5 ASRGL1(1), GBA(4), GBA3(3), SHMT1(6), SHMT2(5) 2285759 19 18 22 9 8 1 2 3 5 0 0.868 1.000 1.000 70 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(5), ICAM1(4), ITGAL(18), ITGAM(13), ITGB2(16), SELE(11), SELL(5) 5180842 72 56 73 22 28 12 7 12 13 0 0.248 1.000 1.000 71 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 7 DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9) 3843584 33 27 33 8 11 8 5 3 6 0 0.217 1.000 1.000 72 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(11), ALAS2(10), CPO(9), FECH(3), GATA1(18), HBB(2), HMBS(4), UROD(2), UROS(5) 4302767 64 46 59 16 19 16 7 13 9 0 0.155 1.000 1.000 73 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(10), CARS2(6), CDO1(3), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), SDS(3), SULT1B1(5), SULT1C2(6), SULT1C4(3), SULT4A1(6) 6472072 85 64 78 21 29 16 11 17 12 0 0.0739 1.000 1.000 74 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 7 OXA1L(5), SEC61A2(4), SRP19(1), SRP54(2), SRP68(10), SRP72(8) 3329702 30 25 30 8 8 7 4 9 2 0 0.319 1.000 1.000 75 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 5 IL13(2), IL13RA1(5), IL4R(6), JAK1(20), TYK2(5) 3686443 38 35 35 10 13 11 0 8 6 0 0.325 1.000 1.000 76 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 5 IL13(2), IL13RA1(5), IL4R(6), JAK1(20), TYK2(5) 3686443 38 35 35 10 13 11 0 8 6 0 0.325 1.000 1.000 77 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(7), IFNAR1(7), IFNAR2(3), IFNB1(6), JAK1(20), STAT1(15), STAT2(10), TYK2(5) 5559736 73 56 64 19 21 17 6 18 11 0 0.183 1.000 1.000 78 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(11), PON2(6), PON3(10), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 4334998 68 50 62 20 17 17 7 17 10 0 0.272 1.000 1.000 79 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(11), ACOX3(8), FADS2(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8) 5392445 63 46 60 14 22 11 7 14 9 0 0.0417 1.000 1.000 80 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(10), CTH(5), GOT1(6), GOT2(2), LDHA(10), LDHB(5), LDHC(4) 3413585 42 38 37 12 14 10 5 7 6 0 0.336 1.000 1.000 81 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(3), CASP7(3), DFFA(4), DFFB(2), ENDOG(3), GZMB(4), HMGB1(2), HMGB2(2), TOP2A(23), TOP2B(24) 4743669 70 55 59 16 10 13 7 20 20 0 0.427 1.000 1.000 82 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 10 ADCY1(22), ADRB2(3), PLCE1(32), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RAP2B(2) 6390625 84 60 81 25 27 21 6 20 10 0 0.128 1.000 1.000 83 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 9 ARNTL(11), CRY2(5), CSNK1D(14), CSNK1E(9), NPAS2(10), NR1D1(7), PER1(12), PER2(7), PER3(18) 7026321 93 65 85 20 38 21 7 21 6 0 0.00470 1.000 1.000 84 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(6), CAT(7), EPX(13), LPO(9), MPO(13), MTHFR(8), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29) 5802832 100 70 89 26 47 13 10 16 14 0 0.0811 1.000 1.000 85 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), CCND1(2), CDK2(5), CDK4(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(3) 3516361 52 43 48 16 8 13 8 11 12 0 0.396 1.000 1.000 86 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), RFK(1), TYR(9) 5145819 67 43 60 15 18 18 8 14 8 1 0.0505 1.000 1.000 87 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), RAC1(2), WASF1(3), WASL(16) 4286018 61 44 58 19 17 7 9 18 10 0 0.398 1.000 1.000 88 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(8), GNAQ(10), ITPKA(3), ITPKB(14) 2758937 40 34 39 14 15 7 3 10 5 0 0.502 1.000 1.000 89 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 7 ADAM17(11), AXIN1(8), BTRC(7), DLL1(6), FZD1(7), GSK3B(16), PSEN1(3) 4038298 58 42 56 20 16 13 8 10 10 1 0.353 1.000 1.000 90 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 10 AKT1(11), BAD(1), HRAS(4), IGF1R(17), IRS1(17), MAPK1(3), MAPK3(3), SHC1(13), SOS1(11), YWHAH(3) 6111064 83 65 71 21 25 11 12 14 20 1 0.176 1.000 1.000 91 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(13), EIF2AK4(21), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF5(6), GSK3B(16), PPP1CA(2) 5915668 79 63 68 18 14 28 5 13 19 0 0.0963 1.000 1.000 92 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3) 3758496 51 39 49 13 14 6 5 8 18 0 0.230 1.000 1.000 93 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(11), ACO2(7), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2) 6796112 74 53 68 18 23 9 13 19 10 0 0.0429 1.000 1.000 94 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 C9orf47(2), CNR1(10), CNR2(1), DNMT1(20), MTNR1A(2), MTNR1B(11), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2) 5210537 69 49 62 19 29 9 6 13 12 0 0.0412 1.000 1.000 95 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(8), ANKRD1(7), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(8), IL18(3), IL1A(1), IL1R1(6), MYOG(5), NR4A3(7), WDR1(7) 5529734 59 40 59 15 16 12 8 15 8 0 0.161 1.000 1.000 96 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(13), GBA3(3), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TPO(29), TYR(9) 4802549 86 64 79 23 41 15 7 13 10 0 0.0874 1.000 1.000 97 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(4), GSR(5), GSS(8), IL8(5), NFKB1(8), NOX1(4), RELA(9), TNF(1), XDH(19) 5182619 63 50 59 17 13 20 7 9 14 0 0.236 1.000 1.000 98 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 7 ADORA1(14), ADORA2A(4), ADORA2B(5), LTB4R(1), P2RY1(5), P2RY2(6), P2RY6(5) 2015662 40 31 38 16 18 9 6 4 3 0 0.335 1.000 1.000 99 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(2), CTSD(6), ESR1(20), GREB1(24), HSPB2(2), MTA1(6), MTA3(3), PDZK1(2), TUBA8(4) 4753786 69 48 69 23 26 7 9 13 14 0 0.349 1.000 1.000 100 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(3), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), MECR(4), PPT1(1), PPT2(4) 4419959 46 40 46 14 12 9 5 11 9 0 0.346 1.000 1.000 101 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(22), CREM(10), FHL5(8), FSHB(4), FSHR(16), XPO1(7) 3889125 67 48 59 21 22 20 8 12 5 0 0.258 1.000 1.000 102 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(7), CS(2), FH(9), IDH2(16), MDH1(8), OGDH(13), SDHA(12), SUCLA2(6) 4929826 73 61 65 23 22 13 8 16 14 0 0.341 1.000 1.000 103 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), CYCS(1), GPD2(10), NDUFA1(2), SDHA(12), SDHB(3), SDHD(4), UQCRC1(4) 3380932 40 30 40 11 17 2 8 10 3 0 0.304 1.000 1.000 104 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(8), ME1(11), PC(12), PDHA1(7), SLC25A1(1), SLC25A11(2) 4576581 55 49 49 16 17 15 7 9 7 0 0.219 1.000 1.000 105 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 21 ABP1(4), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), AOC2(12), AOC3(9), ASPA(6), CNDP1(7), DDC(5), HAL(11), HARS(6), HDC(8), HNMT(11), MAOA(5), MAOB(6), PRPS2(6) 11289946 169 106 154 38 53 29 21 44 22 0 0.00439 1.000 1.000 106 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 CISH(2), IFNG(3), IFNGR1(6), JAK1(20), PTPRU(18), REG1A(6), STAT1(15) 4727773 70 49 65 18 25 14 4 13 13 1 0.221 1.000 1.000 107 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(3), CPS1(31), GLS(2), GLUD1(4), GOT1(6) 4073816 48 37 44 13 11 13 10 10 4 0 0.199 1.000 1.000 108 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(6), ATP6V0C(1), CAT(7), EPX(13), LPO(9), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), SHMT1(6), SHMT2(5), TPO(29) 5869137 99 70 88 27 49 13 10 13 14 0 0.0757 1.000 1.000 109 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(4), UBE2A(4), UBE2B(3), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(3), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(19) 5278573 63 44 61 20 17 11 5 13 17 0 0.384 1.000 1.000 110 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(23), BAD(1), BAK1(2), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), CASP8AP2(27), CASP9(5), CES1(13) 5188402 87 56 79 26 20 8 14 20 24 1 0.621 1.000 1.000 111 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(11), ACO2(7), AFMID(2), CS(2), GRHPR(1), HAO1(11), HAO2(8), HYI(2), MDH1(8), MDH2(3), MTHFD1(8), MTHFD1L(11), MTHFD2(2) 7126627 76 53 70 20 23 9 13 21 10 0 0.0708 1.000 1.000 112 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 174 ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), BAD(1), BCAR1(5), BCL2(2), BIRC2(5), BIRC3(11), CAPN2(8), CAV2(4), CAV3(3), CCND1(2), CCND2(3), CCND3(2), CDC42(2), CHAD(9), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), CRKL(5), DIAPH1(7), DOCK1(22), EGF(7), ELK1(4), ERBB2(28), FARP2(12), FIGF(4), FLNA(24), FLNB(36), FLNC(36), FLT1(34), FN1(52), FYN(15), GRLF1(18), GSK3B(16), HGF(13), HRAS(4), IBSP(6), IGF1(6), IGF1R(17), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), JUN(2), KDR(38), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(1), PDGFD(11), PDGFRA(56), PDGFRB(20), PDPK1(4), PGF(3), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PRKCA(5), PRKCG(19), PTEN(286), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF1(19), RELN(83), ROCK1(27), ROCK2(15), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SPP1(4), SRC(3), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TLN1(21), TLN2(13), TNC(38), TNN(30), TNR(45), TNXB(51), VASP(4), VAV1(22), VAV3(27), VCL(9), VEGFA(5), VEGFC(11), VTN(10), VWF(30), ZYX(2) 167888761 2823 334 2566 1135 798 615 362 619 410 19 0.936 1.000 1.000 113 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 213 ADCYAP1R1(4), ADORA1(14), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA2A(5), ADRA2B(6), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), C5AR1(7), CALCR(8), CALCRL(7), CCKAR(6), CCKBR(12), CGA(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CNR1(10), CNR2(1), CRHR1(4), CRHR2(5), CTSG(4), CYSLTR1(9), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2(9), F2R(11), F2RL2(6), FPR1(5), FSHB(4), FSHR(16), GABBR1(16), GABBR2(15), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GABRB1(10), GABRB2(7), GABRB3(14), GABRD(6), GABRE(10), GABRG1(17), GABRG2(15), GABRG3(11), GABRP(9), GABRQ(16), GABRR1(5), GABRR2(8), GALR1(4), GH1(4), GH2(4), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(6), GLP2R(8), GLRA1(10), GLRA2(8), GLRA3(12), GLRB(13), GNRHR(9), GPR156(15), GPR35(3), GPR50(9), GPR63(4), GPR83(6), GRIA1(35), GRIA2(23), GRIA3(11), GRIA4(36), GRID1(28), GRID2(25), GRIK1(13), GRIK2(43), GRIK3(28), GRIK4(20), GRIK5(14), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRIN3A(16), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM6(24), GRM7(30), GRM8(27), GRPR(4), GZMA(8), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HRH4(6), HTR1A(15), HTR1B(11), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LEP(1), LEPR(15), LHB(3), LTB4R(1), MAS1(2), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), MCHR1(8), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPBWR1(5), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(6), NPY2R(12), NPY5R(5), NR3C1(8), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), P2RY1(5), P2RY10(12), P2RY14(9), P2RY2(6), P2RY4(8), P2RY6(5), PARD3(11), PPYR1(5), PRL(3), PRLHR(5), PRLR(8), PRSS1(6), PRSS3(6), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTH2R(14), RXFP1(6), RXFP2(18), SCTR(5), SSTR1(11), SSTR2(4), SSTR4(12), TAAR1(6), TAAR2(6), TAAR5(8), TAAR6(4), TAAR8(5), TAAR9(6), TACR1(9), TACR2(4), TACR3(11), THRA(6), THRB(14), TRHR(7), TRPV1(9), TSHB(1), TSPO(1), VIPR1(6), VIPR2(11) 102375063 1996 319 1847 758 703 344 229 467 250 3 0.314 1.000 1.000 114 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 160 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY7(10), ADCY8(30), ADCY9(19), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), ATP2A1(23), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), ATP2B4(21), AVPR1A(13), AVPR1B(5), BDKRB1(3), BDKRB2(4), BST1(2), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CCKAR(6), CCKBR(12), CD38(4), CHRM1(4), CHRM2(25), CHRM3(21), CHRM5(5), CYSLTR1(9), DRD1(9), EDNRA(8), EDNRB(13), ERBB2(28), ERBB3(28), ERBB4(56), F2R(11), GNA11(8), GNA14(10), GNA15(5), GNAL(4), GNAQ(10), GRIN1(5), GRIN2A(48), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), GRPR(4), HRH1(4), HRH2(15), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), MYLK(29), MYLK2(9), NOS1(23), NOS3(21), NTSR1(5), OXTR(2), P2RX1(2), P2RX2(5), P2RX3(4), P2RX4(4), P2RX5(3), P2RX7(12), PDE1A(8), PDE1B(10), PDE1C(17), PDGFRA(56), PDGFRB(20), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PPID(4), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTAFR(1), PTGFR(7), PTK2B(13), RYR1(58), RYR2(122), RYR3(82), SLC25A4(4), SLC25A5(8), SLC8A1(22), SLC8A2(14), SLC8A3(13), SPHK1(2), SPHK2(5), TACR1(9), TACR2(4), TACR3(11), TNNC1(2), TNNC2(1), TRHR(7), TRPC1(15), VDAC1(6), VDAC2(4), VDAC3(2) 127915195 2227 317 2117 837 792 394 247 471 313 10 0.547 1.000 1.000 115 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 132 ACTB(4), ACTG1(6), CHAD(9), COL11A2(17), COL17A1(13), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), COMP(6), DES(5), DSC1(12), DSC2(16), DSC3(12), DSG1(19), DSG2(11), DSG3(17), DSG4(24), FN1(52), GJA1(5), GJA10(12), GJA3(4), GJA4(3), GJA5(7), GJA8(19), GJA9(5), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GJB7(3), GJC1(9), GJC3(3), GJD2(4), GJD4(4), IBSP(6), INA(8), ITGA6(14), ITGB4(16), KRT1(18), KRT10(7), KRT12(6), KRT13(11), KRT14(8), KRT15(8), KRT16(5), KRT17(10), KRT18(3), KRT19(4), KRT2(14), KRT20(2), KRT23(9), KRT24(2), KRT25(12), KRT27(2), KRT28(5), KRT3(10), KRT31(12), KRT32(6), KRT33A(8), KRT33B(5), KRT34(11), KRT35(5), KRT36(5), KRT37(8), KRT38(1), KRT39(9), KRT40(2), KRT5(7), KRT6A(7), KRT6B(6), KRT6C(6), KRT7(4), KRT71(9), KRT72(14), KRT73(10), KRT74(7), KRT75(13), KRT76(9), KRT77(6), KRT78(5), KRT79(7), KRT8(4), KRT81(2), KRT82(5), KRT83(3), KRT84(8), KRT85(12), KRT86(4), KRT9(12), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), LMNB1(9), LMNB2(2), NES(28), PRPH(2), RELN(83), SPP1(4), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VIM(7), VTN(10), VWF(30) 118376819 1866 313 1757 728 660 285 264 398 257 2 0.661 1.000 1.000 116 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 81 CD36(3), CD44(5), CD47(8), CHAD(9), COL11A2(17), COL1A1(21), COL1A2(25), COL2A1(19), COL3A1(28), COL4A1(24), COL4A2(16), COL4A4(24), COL4A6(25), COL5A1(43), COL5A2(21), COL5A3(20), COL6A1(11), COL6A3(68), COL6A6(47), DAG1(8), FN1(52), FNDC1(37), FNDC3A(13), FNDC4(6), FNDC5(2), GP5(8), GP6(11), GP9(1), HMMR(15), HSPG2(26), IBSP(6), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB1(12), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LAMA1(59), LAMA2(53), LAMA3(37), LAMA4(35), LAMA5(32), LAMB1(20), LAMB2(13), LAMB3(14), LAMB4(34), LAMC1(21), LAMC2(15), LAMC3(18), RELN(83), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SPP1(4), SV2A(22), SV2B(9), SV2C(13), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNC(38), TNN(30), TNR(45), TNXB(51), VTN(10), VWF(30) 105475958 1610 299 1530 657 553 239 223 357 235 3 0.871 1.000 1.000 117 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 226 ACVR1C(9), AKT1(11), AKT2(7), AKT3(7), ARRB1(4), ARRB2(1), ATF2(6), ATF4(2), BDNF(4), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1F(35), CACNA1G(28), CACNA1H(29), CACNA1I(15), CACNA1S(29), CACNA2D1(28), CACNA2D2(9), CACNA2D3(21), CACNA2D4(12), CACNB1(6), CACNB2(9), CACNB3(2), CACNB4(3), CACNG1(5), CACNG2(5), CACNG3(8), CACNG4(4), CACNG5(8), CACNG6(3), CACNG7(6), CACNG8(2), CASP3(3), CD14(6), CDC25B(11), CDC42(2), CRKL(5), DAXX(14), DDIT3(4), DUSP1(6), DUSP10(5), DUSP16(9), DUSP3(4), DUSP4(6), DUSP5(1), DUSP6(6), DUSP7(6), DUSP9(9), ECSIT(6), EGF(7), ELK1(4), FAS(7), FASLG(3), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF3(5), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR4(11), FLNA(24), FLNB(36), FLNC(36), FOS(4), GADD45G(1), GNA12(6), HRAS(4), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), JUN(2), MAP2K2(2), MAP2K3(8), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAPT(10), MAX(5), MEF2C(15), MKNK1(2), MKNK2(6), MOS(8), MRAS(4), MYC(5), NFATC2(10), NFATC4(11), NFKB1(8), NFKB2(4), NLK(12), NR4A1(3), NTF3(3), NTRK1(16), NTRK2(23), PAK1(10), PAK2(14), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PPM1A(8), PPM1B(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PPP5C(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PTPN5(7), PTPN7(3), PTPRR(11), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF2(29), RASA1(20), RASA2(15), RASGRF1(22), RASGRF2(20), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KA6(15), RRAS(2), RRAS2(4), SOS1(11), SOS2(15), SRF(4), STK3(8), STK4(8), STMN1(1), TAOK1(17), TAOK2(13), TAOK3(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF1A(4), TRAF2(8), TRAF6(4), ZAK(8) 130053210 2017 292 1883 694 641 370 248 425 326 7 0.0710 1.000 1.000 118 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 183 ABI2(3), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ARAF(10), ARHGEF1(13), ARHGEF12(10), ARHGEF4(8), ARHGEF6(16), ARHGEF7(21), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(2), BAIAP2(6), BCAR1(5), BDKRB1(3), BDKRB2(4), CD14(6), CDC42(2), CFL1(2), CFL2(2), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CRKL(5), CSK(3), CYFIP1(15), CYFIP2(10), DIAPH1(7), DIAPH2(24), DIAPH3(17), DOCK1(22), EGF(7), EZR(3), F2(9), F2R(11), FGD1(18), FGD3(15), FGF1(3), FGF10(5), FGF11(2), FGF12(6), FGF13(9), FGF14(11), FGF16(3), FGF17(3), FGF18(3), FGF2(5), FGF20(3), FGF21(2), FGF23(8), FGF3(5), FGF5(5), FGF6(5), FGF7(3), FGF8(3), FGF9(1), FGFR1(20), FGFR2(50), FGFR4(11), FN1(52), GIT1(3), GNA12(6), GNA13(3), GRLF1(18), GSN(4), HRAS(4), IQGAP1(24), IQGAP2(25), IQGAP3(23), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), LIMK1(7), LIMK2(11), MAP2K2(2), MAPK1(3), MAPK3(3), MOS(8), MRAS(4), MSN(6), MYH10(15), MYH14(22), MYH9(40), MYL2(2), MYL7(1), MYLK(29), MYLK2(9), NCKAP1(15), NCKAP1L(21), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDGFA(2), PDGFB(1), PDGFRA(56), PDGFRB(20), PFN2(4), PFN4(6), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PTK2(24), PXN(2), RAC1(2), RAC2(1), RDX(13), ROCK1(27), ROCK2(15), RRAS(2), RRAS2(4), SCIN(10), SLC9A1(9), SOS1(11), SOS2(15), SSH1(13), SSH2(16), SSH3(3), TIAM1(34), TIAM2(24), TMSL3(2), VAV1(22), VAV3(27), VCL(9), WAS(4), WASF1(3), WASF2(5), WASL(16) 127021377 1849 292 1724 677 541 347 226 430 295 10 0.689 1.000 1.000 119 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRB1(2), ADRB2(3), ADRB3(5), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(18), ATP1B1(4), ATP1B2(2), ATP1B3(4), ATP2A2(16), ATP2A3(11), ATP2B1(16), ATP2B2(22), ATP2B3(17), CACNA1A(27), CACNA1B(36), CACNA1C(32), CACNA1D(28), CACNA1E(47), CACNA1S(29), CACNB1(6), CACNB3(2), CALM2(1), CALM3(1), CALR(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CASQ1(4), CASQ2(8), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), GJA1(5), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(8), GJB4(5), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), ITPR1(41), ITPR2(41), ITPR3(39), KCNB1(19), KCNJ3(11), KCNJ5(10), MIB1(8), NME7(6), PEA15(1), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SLC8A3(13), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1) 92811437 1513 284 1458 564 559 244 172 308 222 8 0.365 1.000 1.000 120 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 123 ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), AKT1(11), AKT2(7), AKT3(7), AMOTL1(15), ASH1L(51), CASK(9), CDC42(2), CDK4(3), CGN(15), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTTN(4), EPB41(11), EPB41L1(13), EPB41L2(12), EPB41L3(31), EXOC3(3), EXOC4(19), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), HCLS1(15), HRAS(4), IGSF5(14), INADL(15), JAM2(2), JAM3(9), LLGL1(6), LLGL2(6), MAGI1(27), MAGI2(25), MAGI3(8), MLLT4(17), MPDZ(23), MPP5(6), MRAS(4), MYH1(38), MYH10(15), MYH11(40), MYH13(26), MYH14(22), MYH15(31), MYH2(37), MYH3(39), MYH4(28), MYH6(27), MYH7(24), MYH7B(27), MYH8(42), MYH9(40), MYL2(2), MYL7(1), OCLN(2), PARD3(11), PARD6A(1), PARD6B(2), PARD6G(6), PPM1J(3), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP2R3A(14), PPP2R4(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PTEN(286), RAB13(1), RAB3B(3), RRAS(2), RRAS2(4), SPTAN1(25), SRC(3), SYMPK(11), TJAP1(3), TJP1(21), TJP2(17), TJP3(11), VAPA(2), YES1(9), ZAK(8) 95657856 1647 280 1437 569 484 394 202 321 229 17 0.163 1.000 1.000 121 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 35 ACTA1(12), ACTA2(3), ACTN2(15), ACTN3(6), ACTN4(7), DES(5), DMD(72), FAM48A(9), MYBPC1(9), MYBPC2(16), MYBPC3(14), MYH3(39), MYH6(27), MYH7(24), MYH8(42), MYL2(2), MYL3(1), MYL4(3), NEB(98), TMOD1(7), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(2), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(7), TPM3(6), TPM4(8), TTN(727), VIM(7) 61299408 1189 280 1087 359 338 251 147 336 99 18 0.00156 1.000 1.000 122 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 134 ACTA1(12), ACTA2(3), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADM(5), ARRB1(4), ARRB2(1), ATF1(5), ATF2(6), ATF3(1), ATF4(2), ATF5(2), ATP2A2(16), ATP2A3(11), CACNB3(2), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CNN1(4), CNN2(3), CORIN(18), CREB3(5), CRHR1(4), DGKZ(8), ETS2(4), FOS(4), GABPA(13), GABPB2(3), GBA2(15), GJA1(5), GNAQ(10), GNB1(3), GNB2(2), GNB3(6), GNB4(8), GNB5(3), GNG3(1), GNG4(1), GNG7(2), GRK4(15), GRK5(12), GRK6(9), GSTO1(1), GUCA2B(3), GUCY1A3(25), IGFBP1(2), IGFBP2(3), IGFBP4(4), IGFBP6(2), IL1B(4), IL6(5), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), MIB1(8), MYL2(2), MYL4(3), MYLK2(9), NFKB1(8), NOS1(23), NOS3(21), OXTR(2), PDE4B(9), PDE4D(7), PKIA(8), PKIB(3), PKIG(1), PLCB3(14), PLCD1(9), PLCG1(17), PLCG2(23), PRKACA(1), PRKACB(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), RAMP1(2), RAMP2(2), RAMP3(6), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(7), RGS18(8), RGS19(1), RGS2(6), RGS20(9), RGS3(22), RGS4(8), RGS5(1), RGS6(7), RGS7(10), RGS9(9), RLN1(3), RYR1(58), RYR2(122), RYR3(82), SFN(1), SLC8A1(22), SP1(6), TNXB(51), USP5(9), YWHAB(4), YWHAH(3), YWHAQ(1) 83191834 1352 274 1304 473 470 214 170 288 204 6 0.103 1.000 1.000 123 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 226 ACVR1(6), ACVR2B(12), AMHR2(4), BMP2(8), BMP7(14), BMPR1B(14), CCL11(1), CCL13(1), CCL15(2), CCL16(2), CCL17(1), CCL18(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL4(1), CCL7(2), CCL8(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CD27(4), CD40(6), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(4), CSF1R(15), CSF2RB(13), CSF3(2), CSF3R(18), CX3CL1(4), CX3CR1(5), CXCL1(1), CXCL10(1), CXCL11(3), CXCL12(2), CXCL14(1), CXCL16(2), CXCL5(5), CXCL6(1), CXCL9(6), CXCR3(4), CXCR4(6), CXCR6(1), EDA(2), EDA2R(4), EDAR(6), EGF(7), EPO(1), EPOR(2), FAS(7), FASLG(3), FLT1(34), FLT3(27), FLT3LG(1), FLT4(16), GDF5(11), GH1(4), GH2(4), GHR(12), HGF(13), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL15(1), IL15RA(1), IL17A(2), IL17B(1), IL17RA(7), IL17RB(8), IL18(3), IL18R1(13), IL18RAP(10), IL19(2), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL1RAP(5), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL25(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL8(5), IL9(1), INHBA(17), INHBB(3), INHBC(3), INHBE(2), KDR(38), KITLG(3), LEP(1), LEPR(15), LIF(1), LIFR(35), LTA(1), LTBR(4), MPL(5), NGFR(4), OSM(4), OSMR(20), PDGFB(1), PDGFRA(56), PDGFRB(20), PF4(3), PLEKHO2(7), PPBP(6), PRL(3), PRLR(8), RELT(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(5), TNFRSF11B(5), TNFRSF13B(6), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFRSF8(7), TNFSF10(2), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(3), TNFSF14(3), TNFSF15(3), TNFSF4(4), TNFSF8(4), TPO(29), TSLP(3), VEGFA(5), VEGFC(11), XCL1(1), XCL2(3), XCR1(5) 80887525 1242 270 1145 434 349 229 154 322 183 5 0.173 1.000 1.000 124 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 119 ABL1(27), ABLIM1(8), ABLIM2(7), ABLIM3(15), ARHGEF12(10), CDC42(2), CDK5(2), CFL1(2), CFL2(2), CXCL12(2), CXCR4(6), DCC(36), DPYSL2(9), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(3), EFNB1(6), EFNB3(9), EPHA1(7), EPHA2(12), EPHA3(61), EPHA4(20), EPHA5(39), EPHA6(25), EPHA7(38), EPHA8(16), EPHB1(33), EPHB2(15), EPHB3(12), EPHB4(11), EPHB6(12), FES(6), FYN(15), GNAI1(3), GNAI2(2), GNAI3(2), GSK3B(16), HRAS(4), ITGB1(12), L1CAM(14), LIMK1(7), LIMK2(11), LRRC4C(14), MAPK1(3), MAPK3(3), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NGEF(17), NRP1(11), NTN1(4), NTN4(7), NTNG1(14), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLXNA1(20), PLXNA2(21), PLXNA3(22), PLXNB1(20), PLXNB2(26), PLXNB3(22), PLXNC1(18), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RASA1(20), RGS3(22), RND1(3), ROBO1(30), ROBO3(10), ROCK1(27), ROCK2(15), SEMA3A(17), SEMA3B(7), SEMA3C(17), SEMA3D(22), SEMA3E(17), SEMA3F(12), SEMA3G(8), SEMA4A(12), SEMA4B(3), SEMA4C(5), SEMA4D(17), SEMA4F(9), SEMA4G(9), SEMA5A(19), SEMA5B(22), SEMA6A(8), SEMA6B(6), SEMA6C(11), SEMA6D(11), SEMA7A(2), SLIT1(28), SLIT2(29), SLIT3(23), SRGAP1(23), SRGAP2(9), SRGAP3(19), UNC5A(6), UNC5B(8), UNC5C(13), UNC5D(21) 89659694 1483 268 1375 559 487 269 168 314 237 8 0.777 1.000 1.000 125 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 115 ALCAM(11), CADM1(15), CADM3(13), CD2(7), CD22(15), CD226(4), CD274(4), CD276(6), CD28(4), CD34(7), CD4(4), CD40(6), CD40LG(10), CD6(5), CD80(4), CD86(2), CD8A(1), CD8B(4), CDH15(2), CDH2(33), CDH3(7), CDH4(19), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CNTN1(26), CNTN2(12), CNTNAP1(14), CNTNAP2(33), CTLA4(4), ESAM(6), F11R(4), GLG1(13), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA2(4), HLA-DQB1(1), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), ICAM1(4), ICAM2(5), ICAM3(3), ICOS(2), ICOSLG(4), ITGA4(14), ITGA6(14), ITGA8(16), ITGA9(9), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), ITGB7(7), ITGB8(9), JAM2(2), JAM3(9), L1CAM(14), MAG(9), MPZ(2), MPZL1(7), NCAM1(16), NCAM2(21), NEGR1(4), NEO1(12), NFASC(37), NLGN1(18), NLGN2(4), NLGN3(10), NRCAM(17), NRXN1(41), NRXN2(21), NRXN3(33), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(27), PTPRF(21), PTPRM(38), PVR(1), PVRL1(7), PVRL2(4), PVRL3(4), SDC1(5), SDC2(6), SDC3(5), SDC4(1), SELE(11), SELL(5), SELP(13), SIGLEC1(17), SPN(4), VCAM1(12), VCAN(60) 68250841 1076 261 1022 435 332 161 133 274 173 3 0.895 1.000 1.000 126 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 102 ABL1(27), ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), ATM(200), ATR(43), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDC14A(10), CDC14B(5), CDC16(5), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(5), CDC26(1), CDC27(16), CDC6(6), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CHEK1(10), CREBBP(68), CUL1(16), DBF4(8), E2F2(7), E2F3(5), EP300(42), ESPL1(22), FZR1(3), GADD45G(1), GSK3B(16), HDAC1(5), HDAC2(8), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTTG1(2), RB1(123), RBL1(18), RBL2(22), SFN(1), SKP1(2), SKP2(3), SMAD3(17), SMC1A(21), SMC1B(25), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 66999696 1171 259 1007 396 244 319 117 260 212 19 0.352 1.000 1.000 127 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 69 CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS2(9), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5D(8), INPP5E(3), INPPL1(14), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), OCRL(16), PI4KA(24), PI4KB(5), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3C3(25), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PRKCA(5), PRKCG(19), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14) 59485298 1088 258 933 397 269 309 130 225 146 9 0.634 1.000 1.000 128 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 71 ABL1(27), ACTN1(9), ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGEF6(16), ARHGEF7(21), BCAR1(5), CDC42(2), CDKN2A(7), CSE1L(10), DOCK1(22), EPHB2(15), FYN(15), GRB7(3), GRLF1(18), ILK(3), ITGA1(12), ITGA10(21), ITGA11(8), ITGA2(13), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGB3BP(1), MAP3K11(11), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MRAS(4), MYLK(29), MYLK2(9), P4HB(6), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CB(5), PKLR(11), PLCG1(17), PLCG2(23), PTEN(286), PTK2(24), RALA(7), RHO(4), ROCK1(27), ROCK2(15), SHC1(13), SOS1(11), SOS2(15), SRC(3), TERF2IP(3), TLN1(21), TLN2(13), VASP(4), WAS(4), ZYX(2) 57676510 1062 255 904 400 204 291 135 231 186 15 0.796 1.000 1.000 129 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 82 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADRB1(2), CSNK1D(14), DRD1(9), DRD2(7), EGF(7), GJA1(5), GJD2(4), GNA11(8), GNAI1(3), GNAI2(2), GNAI3(2), GNAQ(10), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), HTR2B(7), HTR2C(13), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K2(2), MAP2K5(4), MAP3K2(8), MAPK1(3), MAPK3(3), MAPK7(6), NPR1(16), NPR2(15), PDGFA(2), PDGFB(1), PDGFD(11), PDGFRA(56), PDGFRB(20), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), PRKX(3), SOS1(11), SOS2(15), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9) 61069517 987 246 929 388 330 178 132 224 121 2 0.719 1.000 1.000 130 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 136 AKT1(11), AKT2(7), AKT3(7), BCL2L1(1), CBLB(14), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(68), CSF2RB(13), CSF3(2), CSF3R(18), EP300(42), EPO(1), EPOR(2), GH1(4), GH2(4), GHR(12), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL10(1), IL10RA(3), IL10RB(6), IL11(6), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(5), IL15(1), IL15RA(1), IL19(2), IL2(4), IL20(3), IL20RA(6), IL21(3), IL21R(11), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(4), IL24(3), IL26(6), IL28A(2), IL28B(5), IL28RA(5), IL29(2), IL2RA(3), IL2RB(4), IL2RG(8), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL6ST(14), IL7(3), IL7R(12), IL9(1), IRF9(6), JAK1(20), JAK3(27), LEP(1), LEPR(15), LIF(1), LIFR(35), MPL(5), MYC(5), OSM(4), OSMR(20), PIAS1(4), PIAS2(4), PIAS3(10), PIAS4(2), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PIM1(3), PRL(3), PRLR(8), PTPN11(31), PTPN6(4), SOCS2(2), SOCS5(10), SOCS7(1), SOS1(11), SOS2(15), SPRED1(9), SPRED2(9), SPRY1(9), SPRY2(2), SPRY4(7), STAM(3), STAM2(4), STAT1(15), STAT2(10), STAT3(10), STAT4(10), STAT5A(8), STAT6(4), TPO(29), TSLP(3), TYK2(5) 67076804 950 246 863 325 254 184 131 244 135 2 0.206 1.000 1.000 131 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 76 ABL1(27), ATM(200), BUB1(13), BUB1B(10), BUB3(3), CCNA1(16), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(15), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNH(7), CDAN1(7), CDC14A(10), CDC14B(5), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(5), CDC6(6), CDK2(5), CDK4(3), CDKN1A(2), CDKN2A(7), CHEK1(10), DTX4(8), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), EP300(42), ESPL1(22), GSK3B(16), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), HDAC8(3), MAD1L1(11), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MPEG1(6), MPL(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(12), PRKDC(80), PTPRA(5), PTTG1(2), RB1(123), RBL1(18), SKP2(3), TBC1D8(11), TFDP1(10), TGFB1(2) 53283839 929 245 791 329 180 277 94 202 160 16 0.523 1.000 1.000 132 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 58 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2L1(1), CDC42(2), CDK2(5), CDKN1B(4), CDKN2A(7), CREB1(3), CREB3(5), CREB5(5), EBP(5), ERBB4(56), F2RL2(6), GAB1(15), GSK3A(6), GSK3B(16), IGF1(6), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), MYC(5), NOLC1(8), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PARD3(11), PARD6A(1), PDK1(5), PIK3CD(10), PPP1R13B(9), PREX1(22), PTEN(286), PTK2(24), PTPN1(10), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SLC2A4(7), SOS1(11), SOS2(15), TSC1(17), TSC2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 34586997 841 245 678 310 150 264 114 170 134 9 0.676 1.000 1.000 133 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 59 APAF1(23), ATM(200), ATR(43), BAI1(11), BID(2), CASP3(3), CASP8(19), CASP9(5), CCNB1(8), CCNB2(5), CCNB3(15), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG1(4), CCNG2(4), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN2A(7), CHEK1(10), CYCS(1), EI24(1), FAS(7), GADD45G(1), GTSE1(2), IGF1(6), MDM2(11), MDM4(6), PPM1D(6), PTEN(286), RCHY1(4), RFWD2(5), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(3), SERPINE1(8), SESN1(5), SESN2(8), SESN3(7), SFN(1), SIAH1(2), STEAP3(6), THBS1(12), TNFRSF10B(4), TP73(5), TSC2(15), ZMAT3(9) 30394265 820 244 636 308 107 305 92 162 137 17 0.748 1.000 1.000 134 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 142 ADORA1(14), ADORA2A(4), ADORA2B(5), ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), AGTR1(12), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCBP2(9), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CCR9(8), CCRL1(4), CCRL2(5), CHML(21), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), CMKLR1(5), CNR1(10), CNR2(1), CX3CR1(5), CXCR3(4), CXCR4(6), DRD1(9), DRD2(7), DRD3(5), DRD5(10), EDNRA(8), EDNRB(13), F2R(11), F2RL2(6), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GPR17(2), GPR173(3), GPR3(3), GPR35(3), GPR37(12), GPR37L1(8), GPR4(6), GPR44(2), GPR50(9), GPR6(7), GPR63(4), GPR77(3), GPR83(6), GPR85(6), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(15), HRH3(1), HTR1A(15), HTR1B(11), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12), LTB4R(1), MAS1(2), MC1R(2), MC3R(13), MC4R(6), MC5R(7), MLNR(3), MTNR1A(2), MTNR1B(11), NMBR(3), NMUR1(7), NMUR2(16), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPN1SW(8), OPN3(6), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OR10A5(3), OR12D3(1), OR1C1(9), OR1F1(4), OR1Q1(4), OR2H1(3), OR7A5(4), OR8B8(5), OXTR(2), P2RY1(5), P2RY10(12), P2RY12(5), P2RY14(9), P2RY2(6), P2RY6(5), PPYR1(5), PTAFR(1), PTGDR(7), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), RGR(3), RHO(4), RRH(5), SSTR1(11), SSTR2(4), SSTR4(12), SUCNR1(3), TRHR(7) 52669576 939 240 875 385 358 175 125 186 95 0 0.304 1.000 1.000 135 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 139 ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ADK(7), ADSL(13), ADSS(5), ADSSL1(6), AK1(1), AK5(7), AK7(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), FHIT(1), GART(5), GDA(6), GMPR(8), GMPR2(3), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NPR1(16), NPR2(15), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE10A(12), PDE11A(13), PDE1A(8), PDE1C(17), PDE2A(10), PDE3B(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6D(2), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PPAT(5), PRIM1(5), PRIM2(2), PRPS1L1(3), PRPS2(6), PRUNE(3), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), XDH(19) 83872504 1072 240 1021 377 310 177 166 244 174 1 0.316 1.000 1.000 136 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 124 AXIN1(8), BTRC(7), CACYBP(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(4), CHD8(35), CREBBP(68), CSNK1A1(3), CSNK1A1L(8), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(13), CTNNBIP1(1), CUL1(16), CXXC4(2), DAAM1(8), DAAM2(15), DKK1(8), DKK4(5), DVL2(11), DVL3(8), EP300(42), FBXW11(12), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LEF1(9), LRP5(11), LRP6(24), MAP3K7(7), MAPK10(14), MAPK8(11), MAPK9(10), MMP7(8), MYC(5), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NKD1(6), NLK(12), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PORCN(3), PPARD(4), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRICKLE1(18), PRICKLE2(14), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), PSEN1(3), RAC1(2), RAC2(1), ROCK1(27), ROCK2(15), RUVBL1(7), SENP2(3), SFRP1(2), SFRP4(5), SFRP5(1), SIAH1(2), SKP1(2), SMAD3(17), TBL1X(8), TBL1XR1(11), TCF7(12), TCF7L1(7), VANGL1(12), VANGL2(9), WIF1(5), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3) 68350442 1038 239 974 381 360 177 119 210 167 5 0.554 1.000 1.000 137 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 72 ABL1(27), ABL2(17), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CBLB(14), CBLC(3), CDKN1A(2), CDKN1B(4), CRKL(5), EGF(7), ELK1(4), ERBB2(28), ERBB3(28), ERBB4(56), EREG(3), GAB1(15), GSK3B(16), HBEGF(1), HRAS(4), JUN(2), MAP2K2(2), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MYC(5), NCK2(4), NRG1(26), NRG2(6), NRG3(14), NRG4(2), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SRC(3), STAT5A(8) 43881700 700 236 634 265 174 154 101 145 125 1 0.826 1.000 1.000 138 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 64 ACP1(5), ACTB(4), ACTG1(6), ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), ACVR1C(9), BAIAP2(6), CDC42(2), CREBBP(68), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNND1(19), EP300(42), ERBB2(28), FARP2(12), FER(15), FGFR1(20), FYN(15), IGF1R(17), INSR(20), IQGAP1(24), LEF1(9), LMO7(31), MAP3K7(7), MAPK1(3), MAPK3(3), MLLT4(17), NLK(12), PARD3(11), PTPN1(10), PTPN6(4), PTPRB(19), PTPRF(21), PTPRJ(15), PTPRM(38), PVRL1(7), PVRL2(4), PVRL3(4), PVRL4(10), RAC1(2), RAC2(1), SMAD3(17), SNAI1(5), SORBS1(11), SRC(3), SSX2IP(8), TCF7(12), TCF7L1(7), TGFBR1(17), TGFBR2(24), TJP1(21), VCL(9), WAS(4), WASF1(3), WASF2(5), WASF3(14), WASL(16), YES1(9) 53558223 865 236 790 298 253 171 104 188 147 2 0.220 1.000 1.000 139 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 FN3K(1), IMPA1(4), IMPA2(3), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(14), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(14), MINPP1(4), MIOX(3), OCRL(16), PI4KA(24), PI4KB(5), PIK3C3(25), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(3), PIP5K1C(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCD3(5), PLCD4(3), PLCE1(32), PLCG1(17), PLCG2(23), PLCZ1(16), PTEN(286), PTPMT1(5), SYNJ1(24), SYNJ2(14) 35623384 765 234 625 273 176 245 88 148 99 9 0.481 1.000 1.000 140 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(1), ACTR3(4), AKT1(11), AKT2(7), AKT3(7), ANGPTL2(13), ARHGAP1(3), ARHGAP4(7), ARHGEF11(20), BTK(11), CDC42(2), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(14), ITPR1(41), ITPR2(41), ITPR3(39), LIMK1(7), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDK1(5), PIK3CD(10), PIK3CG(36), PITX2(2), PPP1R13B(9), PTEN(286), RACGAP1(5), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), SAG(5), WASF1(3), WASL(16) 33083660 768 233 630 290 137 241 95 170 113 12 0.849 1.000 1.000 141 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 116 ACACA(30), ACACB(37), AKT1(11), AKT2(7), AKT3(7), ARAF(10), BAD(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBLB(14), CBLC(3), CRKL(5), ELK1(4), EXOC7(3), FBP1(1), FBP2(4), FLOT1(6), FLOT2(2), FOXO1(8), G6PC(4), G6PC2(2), GCK(3), GSK3B(16), GYS1(5), GYS2(13), HRAS(4), IKBKB(7), INPP5D(8), INSR(20), IRS1(17), IRS4(30), LIPE(9), MAP2K2(2), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK9(10), MKNK1(2), MKNK2(6), PCK1(3), PCK2(6), PDE3A(19), PDE3B(8), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PHKA1(9), PHKA2(15), PHKB(15), PHKG1(4), PHKG2(3), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PKLR(11), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R3A(38), PPP1R3B(4), PPP1R3C(4), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCI(24), PRKCZ(3), PRKX(3), PTPN1(10), PTPRF(21), PYGB(15), PYGL(6), PYGM(10), RAPGEF1(19), RHEB(4), RHOQ(6), RPS6(2), RPS6KB1(9), RPS6KB2(4), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SLC2A4(7), SOCS2(2), SORBS1(11), SOS1(11), SOS2(15), SREBF1(8), TRIP10(4), TSC1(17), TSC2(15) 71564690 936 232 869 334 292 156 123 215 148 2 0.376 1.000 1.000 142 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 98 ACTN1(9), ACTN2(15), ACTN3(6), ACTN4(7), BCAR1(5), CDC42(2), CDH5(7), CLDN1(1), CLDN10(12), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(7), CLDN18(6), CLDN19(3), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(2), CLDN7(2), CLDN8(6), CLDN9(2), CTNNA1(26), CTNNA2(33), CTNNA3(28), CTNND1(19), CXCL12(2), CXCR4(6), CYBB(4), ESAM(6), EZR(3), F11R(4), GNAI1(3), GNAI2(2), GNAI3(2), GRLF1(18), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), ITK(21), JAM2(2), JAM3(9), MAPK12(4), MAPK13(4), MAPK14(7), MLLT4(17), MMP2(12), MMP9(14), MSN(6), MYL2(2), MYL7(1), NCF1(4), NCF2(8), NCF4(4), NOX1(4), NOX3(11), OCLN(2), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PRKCA(5), PRKCG(19), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAC1(2), RAC2(1), RAP1A(1), RAP1B(2), RAPGEF3(6), RAPGEF4(12), RASSF5(6), RHOH(4), ROCK1(27), ROCK2(15), SIPA1(9), TXK(10), VASP(4), VAV1(22), VAV3(27), VCAM1(12), VCL(9) 55956857 832 228 779 311 261 144 86 195 141 5 0.798 1.000 1.000 143 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 62 ADCY1(22), ADCY8(30), ARAF(10), ATF4(2), CACNA1C(32), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CREBBP(68), EP300(42), GNAQ(10), GRIA1(35), GRIA2(23), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), GRM1(32), GRM5(28), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), MAP2K2(2), MAPK1(3), MAPK3(3), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP1CA(2), PPP1CB(5), PPP1CC(1), PPP1R12A(16), PPP1R1A(1), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), RAP1A(1), RAP1B(2), RAPGEF3(6), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15) 48280816 825 227 775 342 276 182 92 166 108 1 0.919 1.000 1.000 144 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(200), CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(2), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), CREB3(5), CREB3L1(5), CREB3L3(4), CREB3L4(4), E2F2(7), E2F3(5), E2F4(2), E2F5(6), E2F6(1), GBA2(15), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), MDM2(11), MNAT1(3), MYC(5), MYT1(20), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLE(37), POLE2(5), PRIM1(5), RB1(123), RBL1(18), RPA1(12), RPA2(1), TFDP1(10), TFDP2(4), TNXB(51) 35738657 724 225 616 256 140 203 77 171 118 15 0.423 1.000 1.000 145 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(11), AKT2(7), AKT3(7), BCR(11), BTK(11), CD19(10), CDKN2A(7), DAPP1(3), FLOT1(6), FLOT2(2), GAB1(15), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), PDK1(5), PHF11(3), PITX2(2), PLCG2(23), PPP1R13B(9), PREX1(22), PTEN(286), PTPRC(27), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SAG(5), SYK(5), TEC(8), VAV1(22) 26597281 694 224 572 246 140 240 94 128 84 8 0.368 1.000 1.000 146 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(39), ABCA10(31), ABCA12(66), ABCA13(70), ABCA3(22), ABCA4(31), ABCA5(33), ABCA6(28), ABCA7(21), ABCA8(23), ABCA9(32), ABCB1(29), ABCB10(10), ABCB11(19), ABCB4(23), ABCB5(24), ABCB6(7), ABCB7(6), ABCB8(8), ABCB9(5), ABCC1(20), ABCC10(18), ABCC11(14), ABCC12(22), ABCC2(18), ABCC3(10), ABCC4(24), ABCC5(20), ABCC6(9), ABCC8(21), ABCC9(22), ABCD1(5), ABCD2(18), ABCD3(5), ABCD4(10), ABCG1(7), ABCG2(12), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(16), TAP1(7), TAP2(15) 57548332 848 223 825 259 221 133 99 240 145 10 0.0122 1.000 1.000 147 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 84 AKT1(11), AKT3(7), BCAR1(5), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(8), CAPN3(10), CAPN5(11), CAPN6(13), CAPN7(11), CAPN9(5), CAPNS1(4), CAV2(4), CAV3(3), CDC42(2), CSK(3), DOCK1(22), FYN(15), GIT2(10), ILK(3), ITGA10(21), ITGA11(8), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGA7(14), ITGA8(16), ITGA9(9), ITGAD(14), ITGAE(11), ITGAL(18), ITGAM(13), ITGAX(16), ITGB1(12), ITGB2(16), ITGB3(12), ITGB4(16), ITGB5(8), ITGB6(17), ITGB7(7), ITGB8(9), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAPK10(14), MAPK12(4), MAPK4(4), MAPK7(6), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAP1B(2), RAPGEF1(19), RHO(4), ROCK1(27), ROCK2(15), SDCCAG8(2), SEPP1(3), SHC1(13), SHC3(5), SORBS1(11), SOS1(11), SRC(3), TLN1(21), TNS1(34), VASP(4), VAV3(27), VCL(9), ZYX(2) 64078650 835 223 787 324 249 125 91 204 159 7 0.939 1.000 1.000 148 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 87 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), AKAP1(7), AKAP10(5), AKAP11(26), AKAP12(30), AKAP2(2), AKAP3(22), AKAP4(14), AKAP5(5), AKAP6(37), AKAP8(7), AKAP9(66), ARHGEF1(13), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(6), GNA13(3), GNA14(10), GNA15(5), GNAI2(2), GNAI3(2), GNAL(4), GNAO1(10), GNAQ(10), GNAZ(3), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(1), GNG4(1), GNG7(2), HRAS(4), IL18BP(1), ITPR1(41), KCNJ3(11), PALM2(1), PDE1A(8), PDE1B(10), PDE1C(17), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE7A(7), PDE7B(4), PDE8A(6), PDE8B(14), PLCB3(14), PPP3CA(3), PPP3CC(5), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKD3(15), RRAS(2), SLC9A1(9), USP5(9) 58423882 860 222 801 319 260 156 102 191 149 2 0.484 1.000 1.000 149 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 106 ADA(5), ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADK(7), ADSL(13), ADSS(5), AK1(1), AK5(7), ALLC(4), AMPD1(16), AMPD2(20), AMPD3(11), ATIC(13), ATP1B1(4), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(4), DCK(3), DGUOK(1), ENPP1(17), ENPP3(10), ENTPD1(4), ENTPD2(4), FHIT(1), GART(5), GDA(6), GMPS(16), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HPRT1(2), IMPDH1(3), IMPDH2(6), ITPA(6), NME1(1), NPR1(16), NPR2(15), NT5C(1), NT5E(6), NT5M(3), PAICS(3), PAPSS1(4), PAPSS2(5), PDE1A(8), PDE4A(12), PDE4B(9), PDE4C(9), PDE4D(7), PDE5A(10), PDE6B(11), PDE6C(10), PDE7B(4), PDE8A(6), PDE9A(10), PFAS(10), PKLR(11), PKM2(4), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), PPAT(5), PRPS1L1(3), PRPS2(6), PRUNE(3), RRM1(2), RRM2(5) 64614815 845 221 800 288 250 134 118 205 137 1 0.344 1.000 1.000 150 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(51), ASH2L(6), C17orf79(1), CARM1(3), CTCFL(18), DOT1L(9), EED(2), EHMT1(9), EHMT2(7), EZH1(8), EZH2(49), FBXO11(14), HCFC1(11), HSF4(4), JMJD4(1), JMJD6(8), KDM6A(26), MEN1(26), MLL(50), MLL2(59), MLL3(75), MLL4(36), MLL5(26), NSD1(25), OGT(8), PAXIP1(17), PPP1CA(2), PPP1CB(5), PPP1CC(1), PRDM2(34), PRDM7(5), PRDM9(33), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), RBBP5(4), SATB1(16), SETD1A(20), SETD7(7), SETD8(6), SETDB1(18), SETDB2(4), SETMAR(3), SMYD3(4), STK38(7), SUV39H1(4), SUV39H2(6), SUV420H1(13), SUV420H2(1), SUZ12(4), WHSC1(25), WHSC1L1(10) 56764468 809 220 713 260 219 185 66 171 157 11 0.367 1.000 1.000 151 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 74 ACVR1(6), ACVRL1(7), AKT1(11), AURKB(6), BUB1(13), CDKL1(3), CDKL2(16), CDS2(9), CLK1(8), CLK2(3), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MAP3K10(10), MOS(8), NEK1(20), NEK3(9), OCRL(16), PAK4(6), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CB(5), PIK3CG(36), PIM2(1), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23), PLK3(3), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), PRKCZ(3), PRKD1(29), PRKG1(12), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KB1(9), STK11(36), TGFBR1(17), VRK1(6) 51756005 805 220 724 283 248 161 102 172 120 2 0.449 1.000 1.000 152 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 43 AKT1(11), AKT2(7), AKT3(7), BRD4(21), CAP1(4), CDC42(2), CDKN2A(7), F2RL2(6), FLOT1(6), FLOT2(2), GSK3A(6), GSK3B(16), IGFBP1(2), INPPL1(14), IRS1(17), IRS4(30), LNPEP(21), MAPK1(3), MAPK3(3), PARD3(11), PARD6A(1), PDK1(5), PIK3CD(10), PPYR1(5), PTEN(286), PTPN1(10), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SERPINB6(2), SFN(1), SHC1(13), SLC2A4(7), SORBS1(11), SOS1(11), SOS2(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 25198396 642 218 502 214 118 225 76 128 86 9 0.138 1.000 1.000 153 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 68 ARAF(10), C7orf16(11), CACNA1A(27), CRHR1(4), GNA11(8), GNA12(6), GNA13(3), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GNAZ(3), GRIA1(35), GRIA2(23), GRIA3(11), GRID2(25), GRM1(32), GRM5(28), GUCY1A2(23), GUCY1A3(25), GUCY1B3(12), GUCY2C(14), GUCY2D(11), GUCY2F(21), HRAS(4), IGF1(6), IGF1R(17), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP2K2(2), MAPK1(3), MAPK3(3), NOS1(23), NOS3(21), NPR1(16), NPR2(15), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), PRKCA(5), PRKCG(19), PRKG1(12), PRKG2(10), RYR1(58) 52563660 858 217 805 340 297 138 110 187 124 2 0.845 1.000 1.000 154 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 87 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), CREB3(5), CREB3L1(5), CREB3L2(4), CREB3L3(4), CREB3L4(4), CREBBP(68), DCT(17), DVL2(11), DVL3(8), EDN1(3), EDNRB(13), EP300(42), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD4(4), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GNAI1(3), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(10), GSK3B(16), HRAS(4), KITLG(3), LEF1(9), MAP2K2(2), MAPK1(3), MAPK3(3), MC1R(2), MITF(14), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), POMC(4), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(19), PRKX(3), TCF7(12), TCF7L1(7), TYR(9), TYRP1(6), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3) 46929709 771 217 733 320 297 137 91 148 98 0 0.737 1.000 1.000 155 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 74 AIFM1(11), AKT1(11), AKT2(7), AKT3(7), APAF1(23), ATM(200), BAD(1), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CAPN1(2), CAPN2(8), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CSF2RB(13), CYCS(1), DFFA(4), DFFB(2), ENDOG(3), FADD(1), FAS(7), FASLG(3), IKBKB(7), IKBKG(2), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL3(6), IRAK1(6), IRAK2(11), IRAK3(9), IRAK4(6), MAP3K14(6), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), NTRK1(16), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), RIPK1(7), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFRSF1A(4), TNFSF10(2), TRAF2(8) 38633361 621 215 546 244 140 158 66 139 112 6 0.945 1.000 1.000 156 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 84 ADCY1(22), ADCY2(27), ADCY3(10), ADCY4(14), ADCY5(26), ADCY6(13), ADCY7(10), ADCY8(30), ADCY9(19), ATF4(2), CACNA1C(32), CACNA1D(28), CACNA1F(35), CACNA1S(29), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDC42(2), CGA(2), ELK1(4), FSHB(4), GNA11(8), GNAQ(10), GNRH1(4), GNRHR(9), HBEGF(1), HRAS(4), ITPR1(41), ITPR2(41), ITPR3(39), JUN(2), LHB(3), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK7(6), MAPK8(11), MAPK9(10), MMP14(6), MMP2(12), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLD1(16), PLD2(7), PRKACA(1), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(15), PRKX(3), PTK2B(13), SOS1(11), SOS2(15), SRC(3) 59773987 878 213 839 307 283 150 113 203 127 2 0.228 1.000 1.000 157 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 52 BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BTRC(7), CSNK1A1(3), CSNK1A1L(8), CSNK1D(14), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(6), DHH(4), FBXW11(12), GLI1(19), GLI2(22), GLI3(37), GSK3B(16), HHIP(15), IHH(5), LRP2(114), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(130), PTCH2(19), RAB23(3), SHH(3), SMO(11), STK36(16), SUFU(5), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT3A(4), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(5), WNT8B(4), WNT9A(7), WNT9B(3) 28066999 615 212 539 225 203 140 67 119 83 3 0.428 1.000 1.000 158 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 79 ACVR1(6), ACVR1C(9), ACVR2B(12), ACVRL1(7), AMHR2(4), BMP2(8), BMP4(5), BMP5(8), BMP6(6), BMP7(14), BMP8A(4), BMPR1B(14), CHRD(14), COMP(6), CREBBP(68), CUL1(16), DCN(7), E2F4(2), E2F5(6), EP300(42), FST(4), GDF5(11), GDF6(6), ID1(2), ID4(1), IFNG(3), INHBA(17), INHBB(3), INHBC(3), INHBE(2), LEFTY1(2), LEFTY2(1), LTBP1(20), MAPK1(3), MAPK3(3), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(2), PPP2R1A(14), PPP2R1B(3), PPP2R2A(8), PPP2R2B(9), PPP2R2C(12), RBL1(18), RBL2(22), ROCK1(27), ROCK2(15), RPS6KB1(9), RPS6KB2(4), SKP1(2), SMAD1(10), SMAD3(17), SMAD5(3), SMAD7(1), SMAD9(5), SMURF1(7), SMURF2(6), SP1(6), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), THBS1(12), THBS2(23), THBS3(7), THBS4(6), TNF(1), ZFYVE16(20), ZFYVE9(18) 45919183 698 209 651 281 230 116 84 150 112 6 0.932 1.000 1.000 159 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 108 ARAF(10), BID(2), CASP3(3), CD244(7), CD247(3), CD48(2), FAS(7), FASLG(3), FCGR3A(4), FCGR3B(2), FYN(15), GZMB(4), HCST(2), HLA-C(13), HLA-E(4), HRAS(4), ICAM1(4), ICAM2(5), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), ITGAL(18), ITGB2(16), KIR2DL1(9), KIR2DL4(5), KIR3DL1(6), KIR3DL2(6), KLRC1(2), KLRC2(2), KLRC3(7), KLRD1(3), KLRK1(7), LAT(2), LCK(8), LCP2(9), MAP2K2(2), MAPK1(3), MAPK3(3), MICB(1), NCR1(2), NCR2(2), NCR3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), PAK1(10), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRF1(7), PRKCA(5), PRKCG(19), PTK2B(13), PTPN11(31), PTPN6(4), RAC1(2), RAC2(1), SH2D1A(3), SH2D1B(1), SH3BP2(6), SHC1(13), SHC2(2), SHC3(5), SHC4(8), SOS1(11), SOS2(15), SYK(5), TNF(1), TNFRSF10A(8), TNFRSF10B(4), TNFRSF10D(1), TNFSF10(2), ULBP1(7), ULBP2(2), ULBP3(5), VAV1(22), VAV3(27), ZAP70(12) 49476575 702 209 637 250 197 132 87 156 128 2 0.459 1.000 1.000 160 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 85 ACTB(4), BAD(1), BCL2(2), CABIN1(22), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(6), CD3E(2), CD69(2), CDKN1A(2), CNR1(10), CREBBP(68), CSNK2A1(7), CSNK2B(2), CTLA4(4), EGR2(14), EGR3(6), EP300(42), FCER1A(5), FCGR3A(4), FOS(4), FOSL1(1), GATA4(4), GRLF1(18), GSK3A(6), GSK3B(16), HRAS(4), ICOS(2), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL13(2), IL1B(4), IL2(4), IL2RA(3), IL3(6), IL4(5), IL6(5), IL8(5), ITK(21), KPNA5(12), MAPK14(7), MAPK8(11), MAPK9(10), MEF2A(5), MEF2D(3), MYF5(5), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB2(4), NFKBIB(5), NFKBIE(4), NPPB(4), NUP214(18), OPRD1(6), P2RX7(12), PAK1(10), PIN1(2), PPIA(1), PPP3CB(10), PPP3CC(5), PPP3R1(3), PTPRC(27), RELA(9), RPL13A(1), SFN(1), SLA(8), SP1(6), SP3(10), TGFB1(2), TNF(1), TRAF2(8), TRPV6(14), VAV1(22), VAV3(27), XPO5(8) 42888283 661 208 619 240 198 161 76 135 91 0 0.373 1.000 1.000 161 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 82 AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHX58(4), ENPP1(17), ENPP3(10), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), G6PC(4), G6PC2(2), GAA(14), GANC(8), GBA(4), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), IFIH1(20), LYZL1(4), MGAM(26), MOV10L1(16), NUDT5(1), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SI(24), SKIV2L2(11), SMARCA2(19), SMARCA5(13), TREH(6), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UXS1(8) 64682837 798 208 738 240 226 141 97 180 151 3 0.0787 1.000 1.000 162 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 29 ACTA1(12), CRKL(5), DOCK1(22), ELK1(4), FOS(4), GAB1(15), HGF(13), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K2(2), MAP4K1(6), MAPK1(3), MAPK3(3), MAPK8(11), PAK1(10), PTEN(286), PTK2(24), PTK2B(13), PTPN11(31), PXN(2), RAP1A(1), RAP1B(2), RASA1(20), SOS1(11), SRC(3), STAT3(10) 18274597 543 206 411 221 63 227 64 115 66 8 0.891 1.000 1.000 163 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 102 A4GNT(5), ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG6(5), ALG8(12), ALG9(7), B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT5(4), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(9), CHST11(4), CHST12(4), CHST14(1), CHST2(11), CHST3(6), CHST4(6), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(12), EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), FUT11(2), FUT8(10), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GANAB(12), GCNT1(7), GCNT3(4), GCNT4(12), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), NDST1(9), NDST2(9), NDST3(15), NDST4(13), OGT(8), RPN1(4), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(5), STT3B(9), UST(10), XYLT1(12) 53181188 735 203 691 272 247 125 85 158 120 0 0.868 1.000 1.000 164 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 81 AKT1(11), AKT2(7), AKT3(7), BCL10(8), CBLB(14), CBLC(3), CD247(3), CD28(4), CD3D(4), CD3E(2), CD4(4), CD40LG(10), CD8A(1), CD8B(4), CDC42(2), CDK4(3), CTLA4(4), FOS(4), FYN(15), GRAP2(3), HRAS(4), ICOS(2), IFNG(3), IKBKB(7), IKBKG(2), IL10(1), IL2(4), IL4(5), ITK(21), JUN(2), LAT(2), LCK(8), LCP2(9), MALT1(12), MAP3K14(6), MAP3K8(4), NCK2(4), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PDCD1(2), PDK1(5), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCQ(15), PTPN6(4), PTPRC(27), RASGRP1(7), SOS1(11), SOS2(15), TEC(8), TNF(1), VAV1(22), VAV3(27), ZAP70(12) 44051292 599 203 555 205 166 123 78 128 104 0 0.246 1.000 1.000 165 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(22), BDKRB1(3), BDKRB2(4), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(14), C2(6), C3(23), C3AR1(10), C4A(3), C4BPA(6), C4BPB(1), C5(20), C5AR1(7), C6(24), C7(10), C8A(11), C8B(22), C8G(1), C9(11), CD46(3), CD55(7), CFB(5), CFH(25), CFI(9), CPB2(10), CR1(19), CR2(20), F10(5), F11(8), F12(5), F13A1(12), F13B(10), F2(9), F2R(11), F3(1), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), KNG1(8), MASP1(19), MASP2(10), MBL2(3), PLAT(10), PLAU(6), PLAUR(7), PLG(23), PROC(3), PROS1(9), SERPINA1(6), SERPINA5(8), SERPINC1(8), SERPIND1(5), SERPINE1(8), SERPINF2(4), SERPING1(5), TFPI(6), THBD(3), VWF(30) 48091564 693 202 656 256 173 113 103 171 129 4 0.804 1.000 1.000 166 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(4), AKT1(11), AKT2(7), AKT3(7), BAD(1), BTK(11), CDKN2A(7), DAPP1(3), GSK3A(6), GSK3B(16), IARS(9), IGFBP1(2), INPP5D(8), PDK1(5), PPP1R13B(9), PTEN(286), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KB1(9), SFN(1), SHC1(13), SOS1(11), SOS2(15), TEC(8), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(3), YWHAQ(1), YWHAZ(3) 16962075 509 201 389 181 74 207 55 94 70 9 0.323 1.000 1.000 167 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 46 ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(13), CREBBP(68), DUSP1(6), EHHADH(13), EP300(42), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(3), ME1(11), MRPL11(1), MYC(5), NCOA1(13), NCOR1(30), NCOR2(38), NFKBIA(1), NR1H3(16), NR2F1(5), NRIP1(17), PDGFA(2), PPARA(7), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), PTGS2(9), RB1(123), RELA(9), RXRA(8), SP1(6), SRA1(2), STAT5A(8), TNF(1) 28903689 536 198 446 189 115 140 54 110 109 8 0.540 1.000 1.000 168 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(200), BMPR1B(14), CCND2(3), CDK4(3), CDKN1B(4), DAZL(2), DMC1(6), EGR1(11), ESR2(8), FSHR(16), GJA4(3), INHA(6), MLH1(62), MSH5(7), NCOR1(30), NR5A1(5), NRIP1(17), PGR(15), PRLR(8), PTGER2(2), SMPD1(9), VDR(3), ZP2(14) 17104668 448 197 365 157 86 137 42 89 88 6 0.484 1.000 1.000 169 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(27), ATM(200), ATR(43), CCNA1(16), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), DHFR(1), GSK3B(16), HDAC1(5), RB1(123), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(6), TGFB3(2) 15235391 497 196 387 192 84 173 38 97 88 17 0.757 1.000 1.000 170 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 19 ATM(200), ATR(43), BRCA1(29), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(10), EP300(42), MDM2(11), MYT1(20), PRKDC(80), RPS6KA1(9), YWHAH(3), YWHAQ(1) 20331472 488 196 405 185 87 150 50 98 93 10 0.817 1.000 1.000 171 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(11), EIF4A2(10), EIF4G1(17), EIF4G2(16), EIF4G3(16), GHR(12), IRS1(17), MAPK1(3), MAPK14(7), MAPK3(3), MKNK1(2), PABPC1(8), PDK2(8), PDPK1(4), PRKCA(5), PTEN(286), RPS6KB1(9) 12492764 434 195 313 165 47 189 55 84 51 8 0.628 1.000 1.000 172 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 66 ACACB(37), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ADIPOR1(2), ADIPOR2(5), AKT1(11), AKT2(7), AKT3(7), CAMKK1(2), CAMKK2(8), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), G6PC(4), G6PC2(2), IKBKB(7), IKBKG(2), IRS1(17), IRS4(30), JAK1(20), JAK3(27), LEP(1), LEPR(15), MAPK10(14), MAPK8(11), MAPK9(10), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NPY(5), PCK1(3), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6), PRKAG3(4), PRKCQ(15), PTPN11(31), RELA(9), RXRA(8), RXRB(7), RXRG(10), SLC2A1(5), SLC2A4(7), STAT3(10), STK11(36), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5) 38961653 603 194 536 190 173 138 86 124 82 0 0.0204 1.000 1.000 173 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 48 ACTG1(6), APAF1(23), ARHGDIB(5), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), GSN(4), LMNB1(9), LMNB2(2), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK8(11), MDM2(11), NFKB1(8), NFKBIA(1), NUMA1(21), PAK2(14), PRKCD(15), PRKDC(80), PSEN1(3), PSEN2(6), PTK2(24), RASA1(20), RB1(123), RELA(9), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8) 32896230 571 193 485 196 116 162 52 121 110 10 0.565 1.000 1.000 174 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 75 ANPEP(16), CD14(6), CD19(10), CD1A(4), CD1B(5), CD1C(3), CD1D(5), CD2(7), CD22(15), CD33(2), CD34(7), CD36(3), CD37(4), CD38(4), CD3D(4), CD3E(2), CD4(4), CD44(5), CD5(7), CD55(7), CD7(4), CD8A(1), CD8B(4), CD9(3), CR1(19), CR2(20), CSF1(4), CSF1R(15), CSF3(2), CSF3R(18), DNTT(11), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(27), FLT3LG(1), GP5(8), GP9(1), HLA-DRB1(6), HLA-DRB5(2), IL11(6), IL11RA(4), IL1A(1), IL1B(4), IL1R1(6), IL1R2(6), IL2RA(3), IL3(6), IL4(5), IL4R(6), IL5RA(9), IL6(5), IL6R(7), IL7(3), IL7R(12), ITGA1(12), ITGA2(13), ITGA2B(6), ITGA3(15), ITGA4(14), ITGA5(17), ITGA6(14), ITGAM(13), ITGB3(12), KITLG(3), MME(23), MS4A1(7), TFRC(5), THPO(5), TNF(1), TPO(29) 39161151 544 192 510 196 160 90 76 138 76 4 0.266 1.000 1.000 175 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 74 ATF2(6), CREB1(3), DAXX(14), ELK1(4), FOS(4), HRAS(4), IKBKB(7), JUN(2), MAP2K2(2), MAP2K3(8), MAP2K5(4), MAP2K6(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K14(6), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K6(10), MAP3K7(7), MAP3K8(4), MAP3K9(9), MAP4K1(6), MAP4K2(5), MAP4K3(16), MAP4K4(19), MAP4K5(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK4(4), MAPK7(6), MAPK8(11), MAPK9(10), MAPKAPK2(4), MAPKAPK3(6), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MKNK2(6), MYC(5), NFKB1(8), NFKBIA(1), PAK1(10), PAK2(14), RAC1(2), RELA(9), RIPK1(7), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA4(5), RPS6KA5(10), RPS6KB1(9), RPS6KB2(4), SHC1(13), SP1(6), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8) 43121185 612 191 563 187 175 110 87 122 116 2 0.0959 1.000 1.000 176 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(11), EIF4A2(10), EIF4B(4), EIF4G1(17), EIF4G2(16), EIF4G3(16), FKBP1A(1), MKNK1(2), PDK2(8), PDPK1(4), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9), TSC1(17), TSC2(15) 11873983 421 191 302 163 49 193 44 72 55 8 0.647 1.000 1.000 177 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ALG6(5), CCKBR(12), CCR2(7), CCR3(9), CCR5(11), CELSR1(27), CELSR2(31), CELSR3(27), CHRM2(25), CHRM3(21), CIDEB(1), CXCR3(4), EDNRA(8), EMR2(7), EMR3(18), F2R(11), FSHR(16), GHRHR(2), GNRHR(9), GPR116(16), GPR132(6), GPR133(15), GPR143(4), GPR17(2), GPR18(3), GPR55(2), GPR56(5), GPR61(9), GPR77(3), GPR84(5), GPR88(4), GRM1(32), GRPR(4), HRH4(6), LGR6(8), LPHN2(26), LPHN3(26), NTSR1(5), OR2M4(15), OR8G1(3), OR8G2(9), PTGFR(7), SMO(11), SSTR2(4), TAAR5(8), VN1R1(7) 29102018 496 189 450 176 157 94 49 116 79 1 0.363 1.000 1.000 178 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(11), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), GSK3B(16), IGF1(6), IGF1R(17), INPPL1(14), PDK2(8), PDPK1(4), PPP2CA(3), PTEN(286), RPS6(2), RPS6KB1(9) 8271910 397 189 281 159 43 194 42 65 45 8 0.825 1.000 1.000 179 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 18 ATM(200), ATR(43), BRCA1(29), BRCA2(77), CHEK1(10), FANCA(9), FANCC(8), FANCE(4), FANCF(3), FANCG(5), HUS1(7), MRE11A(15), RAD1(2), RAD17(7), RAD50(23), RAD9A(1), TREX1(3) 20866140 446 186 351 179 57 143 38 96 102 10 0.974 1.000 1.000 180 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CDK2(5), CDK4(3), CHEK1(10), MYT1(20), RB1(123), YWHAH(3) 8472620 391 184 295 135 64 147 27 80 59 14 0.333 1.000 1.000 181 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(11), BCAR1(5), CDKN1B(4), ILK(3), ITGB1(12), MAPK1(3), MAPK3(3), PDK2(8), PDPK1(4), PTEN(286), PTK2(24), SHC1(13), SOS1(11) 7463883 387 183 268 149 28 186 43 71 50 9 0.697 1.000 1.000 182 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 90 AKT1(11), AKT2(7), AKT3(7), CASP8(19), CCL4(1), CD14(6), CD40(6), CD80(4), CD86(2), CXCL10(1), CXCL11(3), CXCL9(6), FADD(1), FOS(4), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(3), IFNB1(6), IKBKB(7), IKBKE(8), IKBKG(2), IL12A(1), IL12B(1), IL1B(4), IL6(5), IL8(5), IRAK1(6), IRAK4(6), IRF3(2), IRF5(6), JUN(2), LBP(7), LY96(4), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K7(7), MAP3K8(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MYD88(3), NFKB1(8), NFKB2(4), NFKBIA(1), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), RAC1(2), RELA(9), RIPK1(7), SPP1(4), STAT1(15), TBK1(11), TICAM1(15), TIRAP(5), TLR1(8), TLR2(7), TLR3(13), TLR4(15), TLR5(7), TLR6(12), TLR7(15), TLR8(11), TLR9(12), TNF(1), TOLLIP(5), TRAF3(10), TRAF6(4) 40845967 551 182 525 185 136 94 68 148 104 1 0.465 1.000 1.000 183 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(11), AKT2(7), AKT3(7), BPNT1(9), ILK(3), MAPK1(3), MAPK3(3), PDK1(5), PIK3CD(10), PTEN(286), PTK2B(13), RBL2(22), SHC1(13), SOS1(11) 8947690 403 182 284 148 38 183 45 77 51 9 0.684 1.000 1.000 184 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(23), ATM(200), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDKN1A(2), MDM2(11), PCNA(2), RB1(123), TIMP3(10) 8896181 389 176 290 146 55 149 28 82 61 14 0.587 1.000 1.000 185 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 60 ADAM10(8), ADAM17(11), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), CASP3(3), CDC42(2), CSK(3), CXCL1(1), F11R(4), GIT1(3), HBEGF(1), IGSF5(14), IKBKB(7), IKBKG(2), IL8(5), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP3K14(6), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK8(11), MAPK9(10), NFKB1(8), NFKB2(4), NFKBIA(1), NOD1(9), PAK1(10), PLCG1(17), PLCG2(23), PTPN11(31), PTPRZ1(37), RAC1(2), RELA(9), SRC(3), TCIRG1(6), TJP1(21) 31609484 419 174 374 144 109 110 55 87 58 0 0.277 1.000 1.000 186 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(11), APAF1(23), ATM(200), BAD(1), BCL2(2), BCL2L1(1), BID(2), CASP3(3), CASP6(2), CASP7(3), CASP9(5), CYCS(1), EIF2S1(3), PRKCA(5), PTK2(24), PXN(2), STAT1(15), TLN1(21) 13685327 324 172 265 143 57 109 32 66 53 7 0.983 1.000 1.000 187 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 35 AKT1(11), ASAH1(4), ATF1(5), CAMP(1), CREB1(3), CREB3(5), CREB5(5), CREBBP(68), CRKL(5), DAG1(8), EGR1(11), EGR2(14), EGR3(6), EGR4(3), ELK1(4), FRS2(4), GNAQ(10), JUN(2), MAP1B(38), MAPK1(3), MAPK10(14), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), NTRK1(16), OPN1LW(3), PIK3C2G(19), PIK3CD(10), PTPN11(31), RPS6KA3(13), SHC1(13), SRC(3), TERF2IP(3) 21169592 375 171 339 166 85 80 57 82 68 3 0.983 1.000 1.000 188 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(5), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CFLAR(2), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNB1(9), LMNB2(2), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), PTPN13(20), RB1(123), RIPK2(5), SPTAN1(25) 20343617 399 169 333 143 59 118 37 98 77 10 0.790 1.000 1.000 189 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 62 AKT1(11), AKT2(7), AKT3(7), BTK(11), FCER1A(5), FYN(15), GAB2(9), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(8), LAT(2), LCP2(9), LYN(13), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK9(10), MS4A2(3), PDK1(5), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PRKCA(5), PRKCD(15), PRKCE(4), RAC1(2), RAC2(1), SOS1(11), SOS2(15), SYK(5), TNF(1), VAV1(22), VAV3(27) 30808718 436 169 414 150 131 90 58 100 57 0 0.233 1.000 1.000 190 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(27), ATM(200), BRCA1(29), CDKN1A(2), CHEK1(10), JUN(2), MAPK8(11), MDM2(11), MRE11A(15), NFKB1(8), NFKBIA(1), RAD50(23), RBBP8(14), RELA(9), TP73(5) 14272232 367 168 294 159 58 127 29 68 78 7 0.994 1.000 1.000 191 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CD2BP2(7), CDC40(6), CLK2(3), CLK3(7), COL2A1(19), CPSF1(14), CPSF2(10), CPSF3(8), CPSF4(4), CSTF1(4), CSTF2(2), CSTF2T(11), CSTF3(11), DDIT3(4), DDX1(14), DDX20(6), DHX15(8), DHX16(18), DHX38(12), DHX9(12), DICER1(23), DNAJC8(5), FUS(2), GIPC1(4), METTL3(5), NCBP1(8), NCBP2(2), NONO(12), NUDT21(1), NXF1(9), PABPN1(2), PAPOLA(7), PHF5A(1), POLR2A(12), PPM1G(3), PRPF18(4), PRPF3(9), PRPF4(9), PRPF4B(16), PRPF8(17), PSKH1(2), PTBP1(4), PTBP2(13), RBM17(6), RBM5(12), RNGTT(7), RNMT(5), RNPS1(1), SF3A1(10), SF3A2(4), SF3A3(1), SF3B1(17), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(2), SNRPA1(2), SNRPB(2), SNRPB2(3), SNRPD1(2), SNRPD3(1), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(8), SRPK2(9), SRRM1(15), SUPT5H(19), TXNL4A(2), U2AF1(3), U2AF2(6), XRN2(10) 52249220 531 167 503 175 140 80 59 132 119 1 0.866 1.000 1.000 192 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 39 ADAM17(11), APH1A(2), CREBBP(68), CTBP1(5), CTBP2(13), DLL1(6), DLL3(6), DLL4(5), DTX1(6), DTX2(8), DTX3(2), DTX3L(10), DTX4(8), DVL2(11), DVL3(8), EP300(42), HDAC1(5), HDAC2(8), HES1(2), JAG1(15), LFNG(5), MAML1(10), MAML2(8), MAML3(4), MFNG(1), NCOR2(38), NCSTN(6), NOTCH2(29), NOTCH3(27), NOTCH4(15), NUMB(10), NUMBL(6), PSEN1(3), PSEN2(6), PSENEN(2), PTCRA(4), RBPJL(11), RFNG(1), SNW1(9) 28600583 436 166 400 201 131 84 56 72 92 1 0.996 1.000 1.000 193 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 59 AGTR1(12), ATP8A1(11), AVPR1A(13), AVPR1B(5), AVPR2(8), BDKRB1(3), BDKRB2(4), BRS3(3), C3AR1(10), CCKAR(6), CCKBR(12), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR6(3), CCR7(5), CCR8(7), CX3CR1(5), CXCR3(4), CXCR4(6), CXCR6(1), EDNRA(8), EDNRB(13), FPR1(5), FSHR(16), GALR1(4), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(3), GRPR(4), MC1R(2), MC2R(5), MC3R(13), MC4R(6), MC5R(7), NMBR(3), NPY1R(6), NPY2R(12), NPY5R(5), NTSR1(5), NTSR2(8), OPRD1(6), OPRK1(12), OPRL1(3), OPRM1(11), OXTR(2), PPYR1(5), SSTR1(11), SSTR2(4), SSTR4(12), TAC4(4), TACR1(9), TACR2(4), TACR3(11), TRHR(7) 23251323 403 166 377 170 137 81 46 97 42 0 0.704 1.000 1.000 194 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 51 AXIN1(8), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), DVL2(11), DVL3(8), FBXW2(5), FOSL1(1), FZD1(7), FZD10(11), FZD2(10), FZD3(14), FZD5(1), FZD6(13), FZD7(11), FZD8(5), FZD9(5), GSK3B(16), JUN(2), LDLR(9), MAPK10(14), MAPK9(10), MYC(5), PAFAH1B1(6), PLAU(6), PPP2R5C(5), PPP2R5E(8), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCI(24), PRKCQ(15), PRKCZ(3), PRKD1(29), RAC1(2), SFRP4(5), TCF7(12), WNT10A(2), WNT10B(5), WNT11(6), WNT2(2), WNT2B(6), WNT3(5), WNT4(5), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4) 23055717 402 166 374 148 146 89 37 65 64 1 0.335 1.000 1.000 195 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(12), AKT1(11), BDKRB2(4), CALM2(1), CALM3(1), CHRM1(4), CHRNA1(9), FLT1(34), FLT4(16), KDR(38), NOS3(21), PDE2A(10), PDE3A(19), PDE3B(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKG1(12), PRKG2(10), RYR2(122), SLC7A1(6), SYT1(14), TNNI1(2) 19429179 379 165 362 140 106 79 47 92 53 2 0.551 1.000 1.000 196 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 25 ARHGDIB(5), CASP2(8), CASP3(3), CASP8(19), CRADD(3), DFFA(4), DFFB(2), FADD(1), JUN(2), LMNB1(9), LMNB2(2), MADD(22), MAP3K1(18), MAP3K7(7), MAPK8(11), PAK1(10), PAK2(14), PRKDC(80), RB1(123), RIPK1(7), SPTAN1(25), TNF(1), TNFRSF1A(4), TRAF2(8) 18535524 388 165 324 132 73 111 31 86 76 11 0.539 1.000 1.000 197 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 51 AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CAT(7), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADHA(10), KMO(13), KYNU(8), MAOA(5), MAOB(6), SDS(3), TDO2(8), TPH1(2), WARS(3), WARS2(6) 27321782 386 165 367 113 132 73 40 98 42 1 0.0249 1.000 1.000 198 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(35), AR(20), ESR1(20), ESR2(8), HNF4A(8), NPM1(2), NR0B1(10), NR1D1(7), NR1D2(7), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(3), NR2C2(11), NR2E1(12), NR2F1(5), NR2F2(10), NR3C1(8), NR4A1(3), NR4A2(13), NR5A1(5), NR5A2(9), PGR(15), PPARA(7), PPARD(4), PPARG(4), RARA(5), RARB(18), RARG(10), ROR1(19), RORA(6), RORC(5), RXRA(8), RXRB(7), RXRG(10), THRA(6), THRB(14), VDR(3) 20201748 358 163 338 124 123 60 45 76 52 2 0.363 1.000 1.000 199 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 67 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1C1(2), AKR1C2(2), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), CYP1A1(9), CYP1A2(10), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2F1(6), CYP2S1(7), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7) 28509286 385 162 348 108 103 70 42 101 68 1 0.0392 1.000 1.000 200 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 54 AKT1(11), AKT2(7), AKT3(7), BCL10(8), BLNK(1), BTK(11), CD19(10), CD22(15), CD72(3), CD79A(6), CD79B(2), CR2(20), FCGR2B(2), FOS(4), GSK3B(16), HRAS(4), IFITM1(2), IKBKB(7), IKBKG(2), INPP5D(8), JUN(2), LILRB3(6), LYN(13), MALT1(12), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RASGRP3(8), SYK(5), VAV1(22), VAV3(27) 31655590 417 162 394 133 131 72 58 90 66 0 0.0641 1.000 1.000 201 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 14 ABCB1(29), AKT1(11), ATM(200), CDKN1A(2), CPB2(10), CSNK1A1(3), CSNK1D(14), FHL2(2), HIF1A(14), MAPK8(11), MDM2(11), NFKBIB(5), NQO1(1) 9461535 313 162 255 113 49 109 30 69 50 6 0.595 1.000 1.000 202 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), CARM1(3), DBH(8), DCT(17), DDC(5), ECH1(2), ESCO1(16), ESCO2(13), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HEMK1(1), HGD(5), HPD(6), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), MYST3(28), MYST4(25), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SH3GLB1(5), TAT(14), TPO(29), TYR(9), TYRP1(6), WBSCR22(2) 30007730 403 161 360 150 124 80 46 98 54 1 0.576 1.000 1.000 203 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(7), ACADL(4), ACADM(9), ACOX1(11), ACOX2(7), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), CD36(3), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP27A1(4), CYP4A11(7), CYP4A22(13), CYP7A1(13), CYP8B1(9), DBI(2), EHHADH(13), FABP1(2), FABP2(8), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FADS2(10), GK(5), GK2(13), HMGCS2(5), ILK(3), LPL(12), ME1(11), MMP1(5), NR1H3(16), PCK1(3), PCK2(6), PDPK1(4), PLTP(10), PPARA(7), PPARD(4), PPARG(4), RXRA(8), RXRB(7), RXRG(10), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(6), SLC27A4(3), SLC27A5(7), SLC27A6(15), SORBS1(11), UBC(6), UCP1(8) 32916919 442 161 412 125 134 59 71 110 68 0 0.0102 1.000 1.000 204 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 41 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), BCR(11), BLNK(1), BTK(11), CD19(10), CD22(15), CR2(20), CSK(3), DAG1(8), FLOT1(6), FLOT2(2), GSK3A(6), GSK3B(16), INPP5D(8), ITPR1(41), ITPR2(41), ITPR3(39), LYN(13), MAP4K1(6), MAPK1(3), MAPK3(3), NFATC2(10), PDK1(5), PIK3CD(10), PLCG2(23), PPP1R13B(9), PPP3CA(3), PPP3CB(10), PPP3CC(5), PTPRC(27), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22) 32999501 459 161 438 138 145 83 65 95 70 1 0.0194 1.000 1.000 205 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 55 AADAT(1), AANAT(2), ABP1(4), ACAT1(7), ACAT2(8), ACMSD(6), AFMID(2), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), AOX1(12), CARM1(3), CAT(7), CYP1A1(9), CYP1A2(10), DDC(5), ECHS1(3), EHHADH(13), GCDH(6), HAAO(4), HADH(2), HADHA(10), HEMK1(1), HSD17B10(2), HSD17B4(9), INMT(3), KMO(13), KYNU(8), LCMT1(1), LCMT2(6), LNX1(14), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), NFX1(8), OGDH(13), OGDHL(12), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), TDO2(8), TPH1(2), TPH2(9), WARS(3), WARS2(6), WBSCR22(2) 30207186 362 160 345 126 116 66 46 90 44 0 0.374 1.000 1.000 206 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 60 AKT1(11), AKT2(7), AKT3(7), BAD(1), CASP9(5), CDC42(2), HRAS(4), KDR(38), MAP2K2(2), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPKAPK2(4), MAPKAPK3(6), NFAT5(6), NFATC2(10), NFATC3(13), NFATC4(11), NOS3(21), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCG1(17), PLCG2(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PPP3R1(3), PPP3R2(1), PRKCA(5), PRKCG(19), PTGS2(9), PTK2(24), PXN(2), RAC1(2), RAC2(1), SH2D2A(4), SHC2(2), SPHK1(2), SPHK2(5), SRC(3), VEGFA(5) 30992183 410 159 381 167 140 62 52 85 71 0 0.867 1.000 1.000 207 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(8), EIF1(2), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), ELAVL1(5), FLT1(34), FLT4(16), HIF1A(14), HRAS(4), KDR(38), NOS3(21), PLCG1(17), PRKCA(5), PTK2(24), PXN(2), SHC1(13), VHL(83) 14802116 326 159 264 134 57 108 43 62 55 1 0.937 1.000 1.000 208 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(29), CARM1(3), CCND1(2), CREBBP(68), EP300(42), ERCC3(18), ESR1(20), GRIP1(12), GTF2A1(5), GTF2E1(13), GTF2F1(5), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(13), HDAC6(7), MEF2C(15), NCOR2(38), NR0B1(10), NRIP1(17), PELP1(11), POLR2A(12), SRA1(2), TBP(2) 23481084 379 157 340 172 102 76 40 68 93 0 0.998 1.000 1.000 209 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 60 ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CHPT1(3), CRLS1(1), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), ESCO1(16), ESCO2(13), ETNK1(3), GNPAT(17), GPAM(4), GPD1(3), GPD1L(4), GPD2(10), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(28), MYST4(25), NAT6(2), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(11), SH3GLB1(5) 32260243 398 155 368 158 113 74 58 99 53 1 0.871 1.000 1.000 210 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 34 AKT1(11), ATF2(6), CDC42(2), DLD(3), DUSP10(5), DUSP4(6), GAB1(15), GCK(3), IL1R1(6), JUN(2), MAP2K5(4), MAP3K1(18), MAP3K10(10), MAP3K11(11), MAP3K12(13), MAP3K13(20), MAP3K2(8), MAP3K3(6), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK10(14), MAPK7(6), MAPK8(11), MAPK9(10), MYEF2(14), NFATC3(13), NR2C2(11), PAPPA(33), SHC1(13), TRAF6(4), ZAK(8) 24306130 365 155 321 98 97 58 50 80 78 2 0.0603 1.000 1.000 211 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(200), CDC25A(11), CDC25B(11), CDC25C(5), CHEK1(10), MYT1(20), YWHAH(3) 6812035 260 153 209 92 48 91 20 53 42 6 0.505 1.000 1.000 212 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(6), AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ENTPD3(7), ENTPD4(18), ENTPD5(2), ENTPD6(3), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(3), NME7(6), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), PNPT1(10), POLA1(10), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1), PRIM1(5), PRIM2(2), RFC5(6), RRM1(2), RRM2(5), RRM2B(5), TK1(2), TK2(2), TXNRD1(9), TXNRD2(8), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UPB1(7), UPP1(5), UPP2(4), UPRT(6) 42323224 484 153 466 149 127 84 77 122 74 0 0.0440 1.000 1.000 213 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 53 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AGK(6), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CEL(12), DAK(7), DGAT1(5), DGAT2(4), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKI(18), DGKZ(8), GK(5), GK2(13), GLA(7), GLB1(9), GPAM(4), LCT(39), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(12), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3) 28928912 393 153 368 150 109 58 58 123 44 1 0.675 1.000 1.000 214 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(200), ATR(43), CDC25C(5), CHEK1(10), YWHAH(3) 7651852 261 153 200 95 38 89 21 49 55 9 0.703 1.000 1.000 215 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(68), DAXX(14), HRAS(4), PAX3(23), PML(11), RARA(5), RB1(123), SIRT1(7), SP100(14), TNF(1), TNFRSF1A(4), TNFRSF1B(1) 9000330 275 153 217 105 61 95 23 47 41 8 0.587 1.000 1.000 216 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 39 AKT1(11), AKT2(7), AKT3(7), CAB39(2), EIF4B(4), FIGF(4), HIF1A(14), IGF1(6), MAPK1(3), MAPK3(3), PDPK1(4), PGF(3), PIK3CB(5), PIK3CD(10), PIK3CG(36), PIK3R2(3), PIK3R3(3), PIK3R5(5), PRKAA1(8), PRKAA2(15), RHEB(4), RICTOR(24), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), STK11(36), TSC1(17), TSC2(15), ULK2(14), ULK3(3), VEGFA(5), VEGFC(11) 22415002 356 152 328 125 104 71 46 77 56 2 0.471 1.000 1.000 217 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), F10(5), F11(8), F12(5), F2(9), F2R(11), F5(30), F8(43), F9(19), FGA(19), FGB(4), FGG(7), KLKB1(13), PROC(3), PROS1(9), SERPINC1(8), SERPING1(5) 23443152 331 152 309 132 72 62 48 88 59 2 0.705 1.000 1.000 218 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 61 APAF1(23), BAD(1), BAK1(2), BCL2(2), BCL2L1(1), BCL2L11(3), BID(2), BIRC2(5), BIRC3(11), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), GZMB(4), HELLS(12), IKBKB(7), IKBKG(2), IRF1(5), IRF2(10), IRF3(2), IRF4(3), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP3K1(18), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), NFKBIB(5), NFKBIE(4), PLEKHG5(8), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF10B(4), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(7), TNFRSF25(2), TNFSF10(2), TP73(5), TRAF1(5), TRAF2(8), TRAF3(10) 26418395 341 150 310 114 81 67 42 73 78 0 0.530 1.000 1.000 219 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 89 ANK2(71), B3GALT4(4), CDR1(5), DGKI(18), FAU(1), IL6ST(14), MRPL19(4), PIGK(10), RPL10(2), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(5), RPL6(2), RPL7(3), RPL7A(1), RPL8(3), RPL9(3), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(1), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS4X(1), RPS5(2), RPS6(2), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), RPS6KA6(15), RPS6KB1(9), RPS6KB2(4), RPS7(1), RPS9(3), RPSA(1), SLC36A2(3), TBC1D10C(8), TSPAN9(4), UBA52(3), UBB(2), UBC(6) 25701499 326 150 307 94 83 65 45 78 53 2 0.187 1.000 1.000 220 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), ASCC3(29), ATP13A2(14), DDX18(16), DDX19A(5), DDX23(18), DDX4(5), DDX41(7), DDX47(11), DDX50(9), DDX51(4), DDX52(3), DDX54(10), DDX55(10), DDX56(6), DHFR(1), DHX58(4), ENTPD7(7), EP400(52), ERCC2(10), ERCC3(18), FPGS(4), GGH(1), IFIH1(20), MOV10L1(16), NUDT5(1), QDPR(2), RAD54B(11), RAD54L(11), RUVBL2(3), SETX(37), SKIV2L2(11), SMARCA2(19), SMARCA5(13), SPR(7) 31802044 417 149 375 138 132 77 48 86 72 2 0.370 1.000 1.000 221 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 44 ACTA1(12), AGT(10), AKT1(11), CALM2(1), CALM3(1), CALR(1), CAMK1G(5), CAMK4(6), CREBBP(68), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(9), FGF2(5), FKBP1A(1), GATA4(4), GSK3B(16), HAND1(4), HAND2(1), HRAS(4), IGF1(6), LIF(1), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MEF2C(15), MYH2(37), NFATC2(10), NFATC3(13), NFATC4(11), NPPA(1), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RPS6KB1(9), SYT1(14) 21336684 351 148 330 132 102 76 37 78 57 1 0.592 1.000 1.000 222 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 40 CD28(4), CD3D(4), CSK(3), CTLA4(4), DAG1(8), EPHB2(15), GRAP2(3), ITK(21), ITPKA(3), ITPKB(14), LAT(2), LCK(8), LCP2(9), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PLCG1(17), PTPRC(27), RASGRP1(7), RASGRP2(10), RASGRP3(8), RASGRP4(2), SOS1(11), SOS2(15), VAV1(22), ZAP70(12) 24618596 331 148 309 116 85 77 41 70 58 0 0.477 1.000 1.000 223 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(1), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), HSD3B7(3), NSD1(25), OGDH(13), OGDHL(12), PIPOX(8), PLOD1(7), PLOD2(9), PLOD3(6), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SETD1A(20), SETD7(7), SETDB1(18), SHMT1(6), SHMT2(5), SPCS1(2), SPCS3(2), SUV39H1(4), SUV39H2(6), TMLHE(3) 28309731 331 147 312 103 115 49 33 76 58 0 0.224 1.000 1.000 224 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 20 CPEB1(7), ERBB2(28), ERBB4(56), ETS1(6), ETS2(4), ETV6(10), ETV7(3), MAPK1(3), MAPK3(3), NOTCH2(29), NOTCH3(27), NOTCH4(15), PIWIL1(27), PIWIL2(12), PIWIL3(12), PIWIL4(8), SOS1(11), SOS2(15), SPIRE1(4), SPIRE2(7) 18967813 287 146 265 90 83 52 44 67 41 0 0.230 1.000 1.000 225 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(16), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(3), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(4), CDKN2A(7), CDKN2C(3), CDKN2D(1), RB1(123), RBL1(18), TFDP1(10) 8220397 237 145 188 88 41 74 20 59 35 8 0.500 1.000 1.000 226 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 45 ACCN1(13), ADCY4(14), ADCY6(13), ADCY8(30), CACNA1A(27), CACNA1B(36), GNAT3(4), GNB1(3), GNB3(6), GNG3(1), GRM4(15), ITPR3(39), KCNB1(19), PDE1A(8), PLCB2(10), PRKACA(1), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(8), SCNN1B(7), SCNN1G(9), TAS1R1(12), TAS1R2(20), TAS2R1(4), TAS2R10(6), TAS2R13(9), TAS2R14(1), TAS2R16(5), TAS2R3(5), TAS2R38(6), TAS2R39(1), TAS2R4(4), TAS2R40(3), TAS2R41(2), TAS2R43(3), TAS2R46(1), TAS2R5(2), TAS2R50(9), TAS2R60(3), TAS2R7(3), TAS2R8(8), TAS2R9(1), TRPM5(5) 25993568 391 145 379 142 141 47 43 94 65 1 0.619 1.000 1.000 227 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(8), ACOX1(11), ACOX3(8), ACSL1(9), ACSL3(11), ACSL4(10), ACSL5(9), ACSL6(9), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CPT1A(10), CPT1B(13), CPT1C(8), CPT2(2), CYP4A11(7), CYP4A22(13), DCI(3), ECHS1(3), EHHADH(13), GCDH(6), HADH(2), HADHA(10), HADHB(9), HSD17B10(2), HSD17B4(9), PECI(2) 24873648 330 144 307 97 91 61 54 82 42 0 0.0127 1.000 1.000 228 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 49 ALG2(8), BAK1(2), BTK(11), CAD(20), CASP10(7), CASP3(3), CASP8(19), CASP8AP2(27), CD7(4), CSNK1A1(3), DAXX(14), DEDD(2), DEDD2(1), DFFA(4), DIABLO(3), EPHB2(15), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(5), MAP3K1(18), MAP3K5(14), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PFN2(4), PTPN13(20), RALBP1(6), RIPK1(7), ROCK1(27), SMPD1(9), TPX2(9), TRAF2(8), TUFM(6) 30385786 377 144 347 118 92 73 42 95 69 6 0.327 1.000 1.000 229 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 111 ATP12A(28), ATP4A(17), ATP4B(3), ATP5A1(4), ATP5B(6), ATP5C1(4), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), COX10(6), COX15(5), COX17(1), COX4I1(5), COX4I2(3), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(5), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(2), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(7), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(3), NDUFC1(1), NDUFC2(2), NDUFS1(14), NDUFS2(3), NDUFS3(4), NDUFS4(1), NDUFS5(1), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(4), PPA1(3), PPA2(3), SDHA(12), SDHB(3), SDHD(4), TCIRG1(6), UQCRB(2), UQCRC1(4), UQCRC2(11), UQCRFS1(3), UQCRH(1) 28556120 372 142 345 114 123 76 45 65 63 0 0.0288 1.000 1.000 230 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(6), ACTG2(6), ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), CDC42(2), CFL1(2), CFL2(2), FLNA(24), FLNC(36), FSCN1(5), FSCN3(5), GDI1(1), GDI2(2), LIMK1(7), MYH2(37), MYLK(29), MYLK2(9), PAK1(10), PAK2(14), PAK3(17), PAK4(6), PAK6(4), PAK7(20), PFN2(4), RHO(4), ROCK1(27), ROCK2(15), RPS4X(1), VASP(4), WASF1(3), WASL(16) 22575562 347 142 319 121 98 55 42 78 69 5 0.457 1.000 1.000 231 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(18), AMY1A(1), AMY2A(4), AMY2B(2), ENPP1(17), ENPP3(10), G6PC(4), GAA(14), GANAB(12), GBA3(3), GBE1(10), GCK(3), GPI(5), GUSB(4), GYS1(5), GYS2(13), HK1(13), HK2(6), HK3(17), MGAM(26), PGM1(8), PGM3(5), PYGB(15), PYGL(6), PYGM(10), SI(24), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UXS1(8) 30561250 340 142 324 102 97 62 43 70 67 1 0.157 1.000 1.000 232 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 57 A4GALT(6), ABO(5), B3GALNT1(5), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(3), B3GNT1(5), B3GNT2(4), B3GNT3(1), B3GNT4(3), B3GNT5(3), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), B4GALT6(10), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), FUT9(9), GBGT1(1), GCNT2(24), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGX(2), PIGZ(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(12), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7), UGCG(9) 23103991 312 141 286 100 98 59 24 76 54 1 0.395 1.000 1.000 233 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 28 AKT1(11), AR(20), ASAH1(4), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(8), GNA11(8), GNA15(5), GNAI1(3), GNAQ(10), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), MAPK10(14), MAPK14(7), PHKA2(15), PIK3CD(10), PITX2(2), PTX3(3), SRC(3) 18685154 298 141 289 108 101 46 39 76 36 0 0.323 1.000 1.000 234 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 42 ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AKR1B1(3), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), CEL(12), DGAT1(5), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), GK(5), GLA(7), GLB1(9), LCT(39), LIPC(5), LIPF(1), LIPG(4), LPL(12), PNLIP(7), PNLIPRP1(4), PNLIPRP2(5), PPAP2A(2), PPAP2B(2), PPAP2C(3) 22925950 327 140 303 119 88 55 49 96 38 1 0.466 1.000 1.000 235 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 47 ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CLDN1(1), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3) 23534840 330 140 303 133 92 57 42 69 66 4 0.815 1.000 1.000 236 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 47 ABL1(27), ACTB(4), ACTG1(6), ARHGEF2(8), ARPC5(2), ARPC5L(2), CD14(6), CDC42(2), CLDN1(1), CTTN(4), EZR(3), FYN(15), HCLS1(15), ITGB1(12), KRT18(3), LY96(4), NCK2(4), NCL(10), OCLN(2), PRKCA(5), ROCK1(27), ROCK2(15), TLR4(15), TLR5(7), TUBA1A(2), TUBA1B(3), TUBA1C(1), TUBA3C(25), TUBA3D(3), TUBA3E(9), TUBA4A(9), TUBA8(4), TUBAL3(8), TUBB(2), TUBB1(5), TUBB2A(3), TUBB2B(4), TUBB2C(3), TUBB3(8), TUBB4(5), TUBB6(4), TUBB8(9), WAS(4), WASL(16), YWHAQ(1), YWHAZ(3) 23534840 330 140 303 133 92 57 42 69 66 4 0.815 1.000 1.000 237 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 30 AKT1(11), AKT2(7), AKT3(7), ASAH1(4), DAG1(8), DRD2(7), EPHB2(15), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PI3(2), PIK3CB(5), PITX2(2), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), RGS20(9), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT3(10), TERF2IP(3) 26245453 367 140 344 119 113 58 49 87 59 1 0.223 1.000 1.000 238 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(11), BCL2(2), IGF1R(17), MYC(5), POLR2A(12), PPP2CA(3), PRKCA(5), RB1(123), TEP1(29), TERF1(5), TERT(8), TNKS(10), XRCC5(11) 12601305 241 140 189 88 53 75 23 41 41 8 0.498 1.000 1.000 239 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(23), BAD(1), BCL2(2), BCL2A1(2), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CD40(6), CD40LG(10), CRADD(3), CYCS(1), DAXX(14), DFFA(4), DFFB(2), FADD(1), FAS(7), FASLG(3), IKBKE(8), LTA(1), NFKB1(8), NFKBIA(1), NGFR(4), NR3C1(8), NTRK1(16), PTPN13(20), RIPK1(7), SFRS2IP(3), TFG(8), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10), TRAF6(4) 21653585 262 139 238 127 59 65 27 56 55 0 0.999 1.000 1.000 240 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 47 ACHE(3), AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPS(5), CDS2(9), CHAT(16), CHKA(4), CHKB(3), CLC(2), CPT1B(13), DGKA(8), DGKB(23), DGKD(21), DGKE(5), DGKG(7), DGKH(17), DGKZ(8), ETNK1(3), GNPAT(17), GPD1(3), GPD2(10), LCAT(4), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(6), PCYT1A(4), PCYT1B(5), PEMT(2), PISD(5), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLCB2(10), PLCG1(17), PLCG2(23), PPAP2A(2), PPAP2B(2), PPAP2C(3) 24025213 317 138 295 120 102 50 47 77 41 0 0.649 1.000 1.000 241 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 62 ACSS1(6), ACSS2(9), ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), G6PC2(2), GALM(3), GAPDH(2), GAPDHS(3), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3) 28564293 344 137 317 121 112 58 36 83 55 0 0.461 1.000 1.000 242 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(9), ALG10B(9), ALG11(9), ALG12(7), ALG13(14), ALG14(2), ALG2(8), ALG3(2), ALG5(4), ALG6(5), ALG8(12), ALG9(7), B4GALT1(7), B4GALT2(7), B4GALT3(6), DAD1(3), DDOST(4), DHDDS(4), DPAGT1(12), DPM1(3), FUT8(10), GANAB(12), MAN1A1(12), MAN1A2(5), MAN1B1(7), MAN1C1(8), MAN2A1(18), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), MGAT5B(9), RFT1(3), RPN1(4), RPN2(6), ST6GAL1(3), STT3B(9) 21057619 289 137 261 95 74 52 32 74 57 0 0.684 1.000 1.000 243 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(7), ANAPC10(2), ANAPC2(6), ANAPC4(11), ANAPC5(5), ANAPC7(6), BTRC(7), CDC16(5), CDC20(3), CDC23(12), CDC26(1), CDC27(16), CUL1(16), CUL2(14), CUL3(8), FBXW11(12), FZR1(3), ITCH(7), SKP1(2), SKP2(3), SMURF1(7), SMURF2(6), TCEB2(1), UBA1(8), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D4(1), UBE2E1(4), UBE2E2(3), UBE2E3(1), VHL(83), WWP1(18), WWP2(8) 20251453 291 137 253 107 70 76 37 68 38 2 0.582 1.000 1.000 244 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(8), ACAA1(7), ACAA2(2), ACADM(9), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), AOX1(12), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(3), ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HADHB(9), HIBADH(2), HIBCH(2), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), OXCT2(3), PCCA(11), PCCB(5) 22329318 270 136 249 67 82 47 33 55 52 1 0.00879 1.000 1.000 245 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(4), INPP1(7), INPP4A(12), INPP4B(10), INPP5A(6), INPPL1(14), ITPKA(3), ITPKB(14), MIOX(3), OCRL(16), PIK3C2A(15), PIK3C2B(22), PIK3C2G(19), PIK3CB(5), PIK3CG(36), PLCB1(22), PLCB2(10), PLCB3(14), PLCB4(20), PLCD1(9), PLCG1(17), PLCG2(23) 21358953 301 135 272 101 99 53 40 66 42 1 0.389 1.000 1.000 246 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 20 CREBBP(68), DUSP1(6), EP300(42), IKBKB(7), IL1B(4), IL8(5), MAP2K3(8), MAP2K6(4), MAP3K14(6), MAP3K7(7), MAPK14(7), MYD88(3), NFKB1(8), NFKBIA(1), NR3C1(8), RELA(9), TGFBR1(17), TGFBR2(24), TLR2(7), TNF(1) 14289776 242 135 218 96 67 69 31 44 30 1 0.688 1.000 1.000 247 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 36 BCL2(2), DAXX(14), EGF(7), ETS1(6), ETS2(4), FOS(4), HOXA7(3), HRAS(4), IKBKB(7), JUN(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K5(14), MAPK1(3), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), NFKB1(8), NFKBIA(1), PPP2CA(3), PRKCA(5), PRKCD(15), PRKCE(4), PRKCG(19), PRKCH(13), PRKCQ(15), RELA(9), RIPK1(7), SP1(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 20885903 250 134 231 98 73 65 31 48 33 0 0.703 1.000 1.000 248 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(4), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), AOX1(12), DBH(8), DCT(17), DDC(5), FAH(3), GOT1(6), GOT2(2), GSTZ1(4), HGD(5), HPD(6), MAOA(5), MAOB(6), PNMT(3), TAT(14), TPO(29), TYR(9) 15935467 238 134 206 82 83 45 27 56 27 0 0.201 1.000 1.000 249 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), ESCO1(16), ESCO2(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), PRDX6(4), SH3GLB1(5), TAT(14), TPO(29) 17599179 272 132 234 87 100 46 27 53 45 1 0.222 1.000 1.000 250 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 32 ABAT(8), ACACA(30), ACACB(37), ACADM(9), ACAT1(7), ACAT2(8), ACSS1(6), ACSS2(9), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH7A1(6), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), HIBCH(2), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SUCLA2(6), SUCLG1(2), SUCLG2(1) 20537846 273 131 253 60 88 35 40 61 49 0 0.00183 1.000 1.000 251 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 10 AXIN1(8), CREBBP(68), EP300(42), FZD1(7), GSK3B(16), HDAC1(5), LDB1(7), LEF1(9), PITX2(2), TRRAP(61) 12453297 225 131 205 91 70 65 30 28 31 1 0.550 1.000 1.000 252 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(2), AKT1(11), ASAH1(4), CAMP(1), CAV3(3), DAG1(8), DLG4(10), EPHB2(15), GNAI1(3), GNAQ(10), ITPR1(41), ITPR2(41), ITPR3(39), KCNJ3(11), KCNJ5(10), KCNJ9(7), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(4), RYR1(58) 19946564 288 131 281 120 118 41 40 57 31 1 0.650 1.000 1.000 253 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 65 CALR(1), CANX(5), CD4(4), CD74(3), CD8A(1), CD8B(4), CIITA(15), CREB1(3), CTSB(3), CTSL1(6), CTSS(4), HLA-C(13), HLA-DMA(3), HLA-DMB(4), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(6), HLA-DQA2(4), HLA-DQB1(1), HLA-DRB1(6), HLA-DRB5(2), HLA-E(4), HLA-F(4), HSP90AA1(7), HSP90AB1(2), HSPA5(3), IFI30(3), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(9), KIR2DL4(5), KIR2DS4(4), KIR3DL1(6), KIR3DL2(6), KIR3DL3(10), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LGMN(1), LTA(1), NFYA(3), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(14), RFXANK(1), RFXAP(5), TAP1(7), TAP2(15), TAPBP(4) 20383577 292 130 273 94 51 60 39 74 57 11 0.382 1.000 1.000 254 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 41 ABP1(4), AGMAT(3), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH4A1(7), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), MAOA(5), MAOB(6), NOS1(23), NOS3(21), OAT(3), ODC1(5), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), P4HB(6), RARS(7), SMS(4) 21188940 277 129 253 95 93 47 36 57 44 0 0.407 1.000 1.000 255 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(8), ASPH(12), COPS5(1), CREB1(3), EDN1(3), EP300(42), EPO(1), HIF1A(14), JUN(2), LDHA(10), NOS3(21), P4HB(6), VHL(83) 8362614 206 129 164 79 31 76 28 38 33 0 0.651 1.000 1.000 256 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(27), CDKN2A(7), MDM2(11), MYC(5), POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), RAC1(2), RB1(123), TWIST1(3) 7518979 214 128 167 69 40 77 24 39 26 8 0.111 1.000 1.000 257 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 30 ABAT(8), ADC(3), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EARS2(3), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GFPT2(11), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GNPNAT1(1), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSR(5), GSS(8), NADSYN1(4), NAGK(7), PPAT(5), QARS(13) 19930868 253 128 235 67 71 52 33 66 31 0 0.0192 1.000 1.000 258 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 DNAJA3(6), IFNG(3), IFNGR1(6), IFNGR2(4), IKBKB(7), LIN7A(7), NFKB1(8), NFKBIA(1), RB1(123), RELA(9), TNF(1), TNFRSF1A(4), TNFRSF1B(1), USH1C(11), WT1(28) 7579512 219 128 166 77 38 80 17 44 31 9 0.407 1.000 1.000 259 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 50 ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3) 23575550 289 127 263 99 89 55 30 71 44 0 0.382 1.000 1.000 260 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 50 ACYP1(1), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH9A1(4), ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GCK(3), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHB(5), LDHC(4), PDHA1(7), PDHA2(14), PDHB(3), PFKM(2), PFKP(15), PGAM1(4), PGK1(3), PGM1(8), PGM3(5), PKLR(11), PKM2(4), TPI1(3) 23575550 289 127 263 99 89 55 30 71 44 0 0.382 1.000 1.000 261 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 39 ABP1(4), ACY3(4), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH3B1(8), ALDH3B2(7), ALDH7A1(6), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(9), ASPA(6), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(11), HARS(6), HARS2(6), HDC(8), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(5), MAOB(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), PRPS2(6), UROC1(7), WBSCR22(2) 19082580 249 127 235 73 74 46 31 63 35 0 0.0724 1.000 1.000 262 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 40 ACACA(30), ACACB(37), ACAT1(7), ACAT2(8), ACOT12(8), ACSS1(6), ACSS2(9), ACYP1(1), AKR1B1(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHAL6A(5), LDHAL6B(6), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PCK2(6), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4) 23631024 306 127 285 98 96 49 41 67 53 0 0.261 1.000 1.000 263 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(9), AARS2(13), CARS(10), CARS2(6), DARS(4), DARS2(7), EARS2(3), EPRS(23), FARS2(5), FARSA(6), FARSB(11), GARS(8), HARS(6), HARS2(6), IARS(9), IARS2(19), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), MTFMT(1), NARS(4), NARS2(8), PARS2(2), QARS(13), RARS(7), RARS2(7), SARS(5), SARS2(4), TARS(7), TARS2(9), VARS(7), VARS2(9), WARS(3), WARS2(6), YARS(4), YARS2(6) 27433192 289 127 282 69 95 40 38 71 45 0 0.00943 1.000 1.000 264 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(5), GTF2A1L(9), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2F1(5), GTF2H1(4), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(16), TAF1(26), TAF10(1), TAF12(3), TAF13(3), TAF1L(50), TAF2(17), TAF4(9), TAF4B(9), TAF5(11), TAF5L(2), TAF6(8), TAF6L(5), TAF7(2), TAF7L(12), TAF9(2), TAF9B(1), TBPL1(3), TBPL2(2) 18564632 229 127 210 72 59 42 28 65 34 1 0.325 1.000 1.000 265 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 ANKHD1(27), EEF1A2(8), EEF1B2(1), EEF1D(9), EEF1G(1), EEF2(7), EEF2K(10), EIF1AX(1), EIF2AK2(3), EIF2AK3(13), EIF2B1(4), EIF2B2(3), EIF2B3(10), EIF2B4(2), EIF2B5(14), EIF2S1(3), EIF2S2(2), EIF2S3(2), EIF4A2(10), EIF4EBP2(3), EIF4G1(17), EIF4G3(16), EIF5(6), EIF5A(2), EIF5B(20), ETF1(10), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(16), PAIP1(4), SLC35A4(3) 21475371 260 127 227 69 60 63 24 53 60 0 0.0617 1.000 1.000 266 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 34 ACAA1(7), ACAA2(2), ACADL(4), ACADM(9), ACADS(3), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(3), EHHADH(13), HADHA(10), HADHB(9), HIBADH(2), IVD(5), MCCC1(17), MCCC2(6), MCEE(7), MUT(7), OXCT1(3), PCCA(11), PCCB(5), SDS(3) 17911525 240 127 220 56 68 40 32 56 43 1 0.00345 1.000 1.000 267 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 31 ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), BCR(11), CAPN1(2), CAPNS1(4), CAPNS2(4), CRKL(5), CSK(3), FYN(15), HRAS(4), ITGA1(12), ITGB1(12), JUN(2), MAP2K2(2), MAPK1(3), MAPK3(3), MAPK8(11), PTK2(24), PXN(2), RAP1A(1), ROCK1(27), SHC1(13), SOS1(11), SRC(3), TLN1(21), VCL(9), ZYX(2) 20721090 253 126 230 107 73 39 30 56 49 6 0.950 1.000 1.000 268 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(3), CAD(20), CANT1(4), CDA(3), CTPS(5), CTPS2(5), DCK(3), DCTD(4), DHODH(10), DPYD(32), DPYS(10), ENTPD1(4), ITPA(6), NME1(1), NT5C(1), NT5E(6), NT5M(3), POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13), RRM1(2), RRM2(5), TK1(2), TK2(2), TXNRD1(9), TYMS(4), UCK1(1), UCK2(3), UMPS(3), UNG(3), UPB1(7), UPP1(5) 29198675 335 126 320 107 95 55 49 92 44 0 0.181 1.000 1.000 269 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 13 AKT1(11), CREB1(3), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NFKB1(8), RB1(123), RELA(9), SP1(6) 7814192 205 125 158 62 38 68 19 45 27 8 0.101 1.000 1.000 270 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1D1(8), ARSD(9), ARSE(4), CARM1(3), CYP11B1(13), CYP11B2(7), CYP19A1(8), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), WBSCR22(2) 24618252 289 125 277 92 77 50 35 69 58 0 0.241 1.000 1.000 271 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 13 BCL2(2), CREBBP(68), EP300(42), FYN(15), IL2RG(8), IL7(3), IL7R(12), JAK1(20), JAK3(27), LCK(8), NMI(3), PTK2B(13), STAT5A(8) 11749252 229 125 199 85 57 68 23 41 40 0 0.618 1.000 1.000 272 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 28 ADRA1A(10), ADRA1B(5), ADRA1D(4), ADRA2A(5), ADRB1(2), ADRB2(3), ADRB3(5), CHRM1(4), CHRM2(25), CHRM3(21), CHRM4(1), CHRM5(5), DRD1(9), DRD2(7), DRD3(5), DRD5(10), HRH1(4), HRH2(15), HTR1A(15), HTR1B(11), HTR1D(4), HTR1F(9), HTR2B(7), HTR2C(13), HTR4(5), HTR5A(19), HTR6(3), HTR7(12) 11355954 238 125 218 88 101 41 32 37 27 0 0.179 1.000 1.000 273 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(2), CDK5(2), CDK5R1(5), CFL1(2), CHN1(5), LIMK1(7), MAP3K1(18), MYL2(2), MYLK(29), NCF2(8), PAK1(10), PDGFRA(56), PLD1(16), RAC1(2), RALBP1(6), RPS6KB1(9), TRIO(38), VAV1(22), WASF1(3) 15118148 242 125 227 87 60 56 33 55 34 4 0.452 1.000 1.000 274 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 28 ACTR2(1), ACTR3(4), ARHGAP1(3), ARHGAP4(7), ARHGAP6(10), ARHGEF1(13), ARHGEF11(20), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), BAIAP2(6), CFL1(2), DIAPH1(7), GSN(4), LIMK1(7), MYL2(2), MYLK(29), OPHN1(7), PIP5K1A(7), PIP5K1B(3), ROCK1(27), SRC(3), TLN1(21), VCL(9) 21257075 220 125 203 81 70 30 24 51 40 5 0.828 1.000 1.000 275 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 34 CALM2(1), CALM3(1), CD3D(4), CD3E(2), ELK1(4), FOS(4), FYN(15), HRAS(4), JUN(2), LAT(2), LCK(8), MAP3K1(18), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), PTPN7(3), RAC1(2), RASA1(20), RELA(9), SHC1(13), SOS1(11), SYT1(14), VAV1(22), ZAP70(12) 19886463 268 125 241 94 85 56 24 43 59 1 0.538 1.000 1.000 276 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 38 APAF1(23), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIRC2(5), BIRC3(11), CASP2(8), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), FADD(1), FAS(7), FASLG(3), GZMB(4), IKBKG(2), JUN(2), MAP3K1(18), MAP3K14(6), MAPK10(14), MDM2(11), MYC(5), NFKB1(8), NFKBIA(1), PARP1(16), PRF1(7), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(2), TRAF1(5), TRAF2(8) 17722890 229 124 208 74 55 49 29 44 52 0 0.312 1.000 1.000 277 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 43 AACS(7), AADAC(5), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ACSM1(8), AKR1B10(3), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH7A1(6), ALDH9A1(4), BDH1(3), BDH2(2), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADH(2), HADHA(10), HMGCS1(1), HMGCS2(5), HSD17B10(2), HSD17B4(9), HSD3B7(3), ILVBL(8), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(7), PDHA2(14), PDHB(3), PLA1A(8), PPME1(2), PRDX6(4), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 19941452 262 124 242 79 87 47 31 64 33 0 0.0510 1.000 1.000 278 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 34 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCR(11), BLNK(1), BTK(11), CD19(10), CSK(3), DAG1(8), EPHB2(15), ITPKA(3), ITPKB(14), LYN(13), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PI3(2), PIK3CD(10), PLCG2(23), PPP1R13B(9), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SYK(5), VAV1(22) 22232517 263 124 246 76 93 43 35 56 35 1 0.0278 1.000 1.000 279 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 32 AKT1(11), ATF1(5), CDC42(2), CREB1(3), CREB3(5), CREB5(5), DUSP1(6), DUSP10(5), EEF2K(10), ELK1(4), IL1R1(6), MAP2K3(8), MAP2K6(4), MAP3K10(10), MAP3K4(49), MAP3K5(14), MAP3K7(7), MAPK1(3), MAPK12(4), MAPK13(4), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MKNK1(2), MKNK2(6), MYEF2(14), NFKB1(8), NR2C2(11), SRF(4), TRAF6(4) 16458665 231 124 205 59 60 41 35 48 46 1 0.0199 1.000 1.000 280 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(3), CDK6(3), CDKN1A(2), CDKN1B(4), HRAS(4), MAPK1(3), MAPK3(3), NFKB1(8), NFKBIA(1), PAK1(10), RAC1(2), RB1(123), RELA(9), TFDP1(10) 7730754 209 123 160 74 36 70 21 44 30 8 0.455 1.000 1.000 281 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(4), AKT1(11), AKT2(7), AKT3(7), DAG1(8), GNAQ(10), IKBKG(2), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PIK3CB(5), PITX2(2), PLD1(16), PLD2(7), PLD3(7), VN1R1(7) 21502783 273 123 263 93 87 55 38 57 36 0 0.276 1.000 1.000 282 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(8), F12(5), F13B(10), F2(9), F5(30), F7(6), F8(43), F9(19), FGA(19), FGB(4), FGG(7), LPA(28), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8), SERPINF2(4), VWF(30) 18220608 283 122 259 109 68 53 42 72 45 3 0.740 1.000 1.000 283 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 49 ALOX12(3), ALOX12B(4), ALOX15(4), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP2U1(5), CYP4A11(7), CYP4A22(13), CYP4F2(12), CYP4F3(10), DHRS4(1), EPHX2(5), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11) 19659459 241 122 227 84 76 37 35 63 30 0 0.424 1.000 1.000 284 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 ACTR2(1), ACTR3(4), AKT1(11), ANGPTL2(13), DAG1(8), DGKA(8), ETFA(4), GCA(1), ITGA9(9), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), MAPK1(3), MAPK3(3), NR1I3(3), PAK1(10), PDE3A(19), PDE3B(8), PI3(2), PIK3C2G(19), PIK3CD(10), PLDN(1), PSME1(1), RIPK3(5), RPS4X(1), SGCB(3), VASP(4) 21788080 289 122 280 107 85 50 35 71 47 1 0.646 1.000 1.000 285 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 25 ACVR1(6), ATF2(6), AXIN1(8), BMP10(13), BMP2(8), BMP4(5), BMP5(8), BMP7(14), CHRD(14), FZD1(7), GATA4(4), GSK3B(16), MAP3K7(7), MEF2C(15), MYL2(2), NPPA(1), NPPB(4), RFC1(20), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14) 12012447 223 121 206 77 83 37 25 48 29 1 0.284 1.000 1.000 286 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 24 DPM2(1), ELK1(4), GNB1(3), HRAS(4), IGF1R(17), ITGB1(12), KLK2(4), MAP2K2(2), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MYC(5), NGFR(4), PDGFRA(56), PPP2CA(3), PTPRR(11), RPS6KA1(9), RPS6KA5(10), SHC1(13), SOS1(11), SRC(3), STAT3(10) 13278982 196 120 177 80 48 49 27 38 31 3 0.790 1.000 1.000 287 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(8), AGXT2(8), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), ATP6V0C(1), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CPT1B(13), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), MAOA(5), MAOB(6), PEMT(2), PISD(5), PLCB2(10), PLCG1(17), PLCG2(23), PSPH(1), SARDH(15), SARS(5), SHMT1(6), SHMT2(5), TARS(7) 21297265 264 120 242 97 95 39 35 51 44 0 0.604 1.000 1.000 288 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(9), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(5), ADSSL1(6), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), ASRGL1(1), ASS1(4), CAD(20), CRAT(10), DARS(4), DARS2(7), DDO(6), DLAT(7), DLD(3), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), NARS2(8), PC(12), PDHA1(7), PDHA2(14), PDHB(3) 19177377 244 120 230 87 81 36 37 53 37 0 0.465 1.000 1.000 289 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(28), ATP4B(3), ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ATP7A(11), ATP7B(14), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(2), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(14), NDUFS2(3), NDUFV1(5), NDUFV2(3), PPA2(3), SDHA(12), SDHB(3), SHMT1(6), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1) 19721532 243 120 225 83 80 43 32 45 43 0 0.232 1.000 1.000 290 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 33 AKT1(11), AKT2(7), AKT3(7), ARHGEF11(20), BCL2(2), CDC42(2), DLG4(10), GNA13(3), IKBKG(2), LPA(28), MAP3K1(18), MAP3K5(14), MAPK8(11), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PDK1(5), PHKA2(15), PI3(2), PIK3CB(5), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RDX(13), ROCK1(27), ROCK2(15), SERPINA4(5), SRF(4) 24295795 302 120 279 94 88 48 30 74 57 5 0.399 1.000 1.000 291 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 29 BTK(11), CALM2(1), CALM3(1), ELK1(4), FCER1A(5), FOS(4), HRAS(4), JUN(2), LYN(13), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PAK2(14), PLA2G4A(13), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22) 17416511 241 119 221 71 66 53 28 49 44 1 0.151 1.000 1.000 292 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(26), GABBR1(16), GPRC5A(5), GPRC5B(3), GPRC5C(9), GPRC5D(3), GRM1(32), GRM2(13), GRM3(17), GRM4(15), GRM5(28), GRM7(30), GRM8(27) 10083260 224 119 193 88 92 30 27 44 31 0 0.620 1.000 1.000 293 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 30 BLNK(1), BTK(11), CALM2(1), CALM3(1), CD79A(6), CD79B(2), ELK1(4), FOS(4), HRAS(4), JUN(2), LYN(13), MAP3K1(18), MAPK14(7), MAPK3(3), MAPK8(11), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), RAC1(2), SHC1(13), SOS1(11), SYK(5), SYT1(14), VAV1(22) 17605417 229 118 211 78 68 47 27 45 41 1 0.457 1.000 1.000 294 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 32 AGT(10), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CDK5(2), F2(9), FYN(15), GNA11(8), GNAI1(3), GNB1(3), HRAS(4), MAP2K2(2), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), MAPT(10), MYLK(29), PLCG1(17), PRKCA(5), PTK2B(13), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), SYT1(14) 18586413 253 118 228 99 64 46 34 55 53 1 0.839 1.000 1.000 295 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 25 ABAT(8), ABP1(4), ACADL(4), ACADM(9), ACADSB(7), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), MLYCD(4), SDS(3), SMS(4), UPB1(7) 13985050 234 117 219 60 71 31 35 68 29 0 0.00611 1.000 1.000 296 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(8), AGXT2(8), AKR1B10(3), ALAS1(11), ALAS2(10), AMT(2), AOC2(12), AOC3(9), BHMT(8), CBS(3), CHDH(3), CHKA(4), CHKB(3), CTH(5), DAO(7), DLD(3), DMGDH(12), GAMT(6), GARS(8), GATM(2), GCAT(3), GLDC(12), GNMT(3), HSD3B7(3), MAOA(5), MAOB(6), PEMT(2), PHGDH(3), PIPOX(8), PISD(5), PSAT1(6), PSPH(1), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SARDH(15), SARS(5), SARS2(4), SDS(3), SHMT1(6), SHMT2(5), TARS(7), TARS2(9) 22029091 256 117 241 90 89 35 35 58 39 0 0.446 1.000 1.000 297 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(16), CCNE1(6), CDC34(2), CDK2(5), CUL1(16), RB1(123), SKP2(3), TFDP1(10) 4612671 181 117 133 64 31 63 10 43 26 8 0.387 1.000 1.000 298 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(3), B4GALT1(7), B4GALT2(7), G6PC(4), G6PC2(2), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANC(8), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), HSD3B7(3), LALBA(1), LCT(39), MGAM(26), PFKL(7), PFKM(2), PFKP(15), PGM1(8), PGM3(5), RDH11(3), RDH12(6), RDH13(4), RDH14(1), UGP2(10) 18749746 246 116 235 87 87 40 30 61 28 0 0.343 1.000 1.000 299 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 10 CREBBP(68), EP300(42), MAP3K7(7), MAPK3(3), SKIL(7), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24) 9225487 178 116 156 79 55 53 21 25 24 0 0.860 1.000 1.000 300 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 39 CDC6(6), CDK2(5), DIAPH2(24), GMNN(3), MCM10(10), MCM2(4), MCM3(3), MCM4(12), MCM5(6), MCM6(8), MCM7(12), NACA(20), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(5), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), PRIM1(5), RFC1(20), RFC2(2), RFC4(8), RFC5(6), RPA1(12), RPA2(1), RPA4(5), UBA52(3), UBB(2), UBC(6) 24800410 270 115 247 89 56 51 35 70 57 1 0.496 1.000 1.000 301 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(8), ACP5(4), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CYP19A1(8), CYP1A1(9), CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), CYP2B6(4), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2D6(8), CYP2E1(9), CYP2F1(6), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(9), CYP4B1(11), CYP4F8(4), CYP51A1(3), PON1(11) 14763894 222 115 217 66 85 37 21 53 25 1 0.0786 1.000 1.000 302 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(8), ALDH4A1(7), ALDH5A1(8), CAD(20), CPS1(31), EPRS(23), GAD1(15), GAD2(15), GCLC(8), GCLM(3), GFPT1(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), GMPS(16), GOT1(6), GOT2(2), GPT(6), GPT2(4), GSS(8), NADSYN1(4), PPAT(5), QARS(13) 17216991 223 115 205 54 58 49 29 61 26 0 0.00919 1.000 1.000 303 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 35 ATF2(6), CDC42(2), CREB1(3), DAXX(14), DDIT3(4), ELK1(4), HRAS(4), HSPB2(2), MAP2K6(4), MAP3K1(18), MAP3K5(14), MAP3K7(7), MAP3K9(9), MAPK14(7), MAPKAPK2(4), MAPKAPK5(6), MAX(5), MEF2A(5), MEF2C(15), MEF2D(3), MKNK1(2), MYC(5), PLA2G4A(13), RAC1(2), RIPK1(7), RPS6KA5(10), SHC1(13), STAT1(15), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TRAF2(8) 18046677 238 115 222 74 76 47 26 47 41 1 0.302 1.000 1.000 304 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 20 CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), JAK1(20), JUN(2), MAP3K1(18), MAPK3(3), MAPK8(11), PDGFA(2), PDGFRA(56), PLCG1(17), PRKCA(5), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8) 14396620 234 115 210 81 56 51 25 54 45 3 0.671 1.000 1.000 305 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(6), CDK2(5), CDKN1B(4), CKS1B(2), CUL1(16), RB1(123), SKP2(3), TFDP1(10), UBE2M(2) 4522685 171 114 125 60 26 61 10 37 29 8 0.473 1.000 1.000 306 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 21 ATF2(6), BCR(11), BLNK(1), ELK1(4), FOS(4), HRAS(4), JUN(2), LYN(13), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8IP3(11), PAPPA(33), RAC1(2), RPS6KA1(9), RPS6KA3(13), SHC1(13), SOS1(11), SYK(5), VAV1(22), VAV3(27) 14252438 215 114 198 56 66 43 28 48 29 1 0.0218 1.000 1.000 307 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 18 ADCY1(22), CD3D(4), CD3E(2), CD4(4), CREBBP(68), CSK(3), GNB1(3), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12) 10162075 184 113 169 75 51 53 20 30 28 2 0.696 1.000 1.000 308 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 18 ADCY1(22), CD3D(4), CD3E(2), CD4(4), CREBBP(68), CSK(3), GNB1(3), HLA-DRB1(6), LCK(8), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTPRC(27), ZAP70(12) 10162075 184 113 169 75 51 53 20 30 28 2 0.696 1.000 1.000 309 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 33 CALM2(1), CALM3(1), CAMK1G(5), ELK1(4), FPR1(5), GNA15(5), GNB1(3), HRAS(4), MAP2K2(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), NCF1(4), NCF2(8), NFATC2(10), NFATC3(13), NFATC4(11), NFKB1(8), NFKBIA(1), PAK1(10), PIK3C2G(19), PLCB1(22), PPP3CA(3), PPP3CB(10), PPP3CC(5), RAC1(2), RELA(9), SYT1(14) 17347368 222 113 210 82 67 42 25 52 35 1 0.601 1.000 1.000 310 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 29 ABAT(8), ACACA(30), ACADL(4), ACADM(9), ACADSB(7), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH6A1(5), ALDH9A1(4), ECHS1(3), EHHADH(13), HADHA(10), LDHA(10), LDHB(5), LDHC(4), MCEE(7), MLYCD(4), MUT(7), PCCA(11), PCCB(5), SDS(3), SUCLA2(6), SUCLG1(2), SUCLG2(1) 16495616 227 113 207 51 68 32 33 52 42 0 0.00872 1.000 1.000 311 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 34 ACACA(30), ACAT1(7), ACAT2(8), ACYP1(1), ADH5(6), AKR1B1(3), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), DLAT(7), DLD(3), GRHPR(1), HAGH(1), LDHA(10), LDHB(5), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PKLR(11), PKM2(4) 17789126 240 113 218 82 69 45 31 55 40 0 0.458 1.000 1.000 312 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 21 AKT1(11), AKT2(7), AKT3(7), BAD(1), BCL2(2), GSK3A(6), GSK3B(16), IL4R(6), IRS1(17), JAK1(20), JAK3(27), MAP4K1(6), MAPK1(3), MAPK3(3), PDK1(5), PIK3CD(10), PPP1R13B(9), SHC1(13), SOS1(11), SOS2(15), STAT6(4) 14695928 199 113 175 55 57 43 21 38 39 1 0.130 1.000 1.000 313 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(6), ELK1(4), FOS(4), IKBKB(7), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), PPARA(7), RELA(9), TIRAP(5), TLR10(11), TLR2(7), TLR3(13), TLR4(15), TLR6(12), TLR7(15), TLR9(12), TOLLIP(5), TRAF6(4) 17411286 223 113 218 65 57 40 23 60 42 1 0.199 1.000 1.000 314 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 18 AXIN1(8), BTRC(7), CCND1(2), CREBBP(68), CSNK1A1(3), CSNK1D(14), CSNK2A1(7), CTBP1(5), FZD1(7), GSK3B(16), HDAC1(5), MAP3K7(7), MYC(5), NLK(12), PPARD(4), PPP2CA(3), TLE1(7), WIF1(5) 10164911 185 113 171 75 50 40 32 33 29 1 0.674 1.000 1.000 315 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(22), AKT1(11), ASAH1(4), GNAI1(3), GNB1(3), ITGB3(12), MAPK1(3), MAPK3(3), PDGFA(2), PDGFRA(56), PLCB1(22), PRKCA(5), PTK2(24), RAC1(2), SMPD1(9), SMPD2(3), SPHK1(2), SRC(3) 11023088 189 112 168 80 49 51 27 42 18 2 0.800 1.000 1.000 316 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(7), B4GALT2(7), FBP2(4), G6PC(4), GAA(14), GALE(4), GALK1(2), GALK2(4), GALT(3), GANAB(12), GCK(3), GLA(7), GLB1(9), HK1(13), HK2(6), HK3(17), LALBA(1), LCT(39), MGAM(26), PFKM(2), PFKP(15), PGM1(8), PGM3(5) 15965997 215 112 207 80 74 40 26 50 25 0 0.538 1.000 1.000 317 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 24 ABAT(8), ABP1(4), ACADM(9), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AOC2(12), AOC3(9), CNDP1(7), DPYD(32), DPYS(10), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), HIBCH(2), MLYCD(4), SMS(4), SRM(1), UPB1(7) 13395242 218 112 203 60 68 30 32 61 27 0 0.0258 1.000 1.000 318 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(11), ALAS2(10), BLVRA(2), BLVRB(1), COX10(6), COX15(5), CP(18), CPOX(3), EARS2(3), EPRS(23), FECH(3), FTH1(1), FTMT(7), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), MMAB(1), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), UROD(2), UROS(5) 21277127 250 112 225 63 57 47 32 62 52 0 0.0881 1.000 1.000 319 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(9), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), CYP2C19(11), CYP2C9(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), HADHA(10), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3) 15312600 226 112 204 71 62 46 28 52 37 1 0.290 1.000 1.000 320 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ACTG1(6), ACTG2(6), ADCY3(10), ADCY9(19), AK1(1), ARF1(1), ARF4(4), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(5), ATP6V0A2(6), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(9), ATP6V1A(11), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(4), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), ERO1L(3), PDIA4(7), PLCG1(17), PLCG2(23), PRKCA(5), SEC61A1(9), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(13) 18091256 227 112 199 89 76 53 26 38 34 0 0.658 1.000 1.000 321 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 AGT(10), AGTR1(12), ATF2(6), CALM2(1), CALM3(1), ELK1(4), GNAQ(10), HRAS(4), JUN(2), MAP2K2(2), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), MEF2A(5), MEF2C(15), MEF2D(3), PAK1(10), PRKCA(5), PTK2(24), PTK2B(13), RAC1(2), SHC1(13), SOS1(11), SRC(3), SYT1(14) 14339906 205 111 188 77 43 42 20 55 44 1 0.866 1.000 1.000 322 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREB1(3), CREBBP(68), EP300(42), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RARA(5), RXRA(8) 10639166 168 111 157 77 41 45 25 30 27 0 0.927 1.000 1.000 323 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 30 ADCY1(22), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(4), GNAI1(3), GNAQ(10), GNB1(3), HRAS(4), JUN(2), MAPK3(3), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RPS6KA3(13), SYT1(14) 14772134 186 111 169 77 62 50 16 30 28 0 0.736 1.000 1.000 324 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 29 AADAT(1), AASDH(20), AASDHPPT(2), AASS(11), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), ATP6V0C(1), BBOX1(3), DLST(3), DOT1L(9), ECHS1(3), EHHADH(13), EHMT1(9), EHMT2(7), GCDH(6), HADHA(10), PLOD1(7), PLOD2(9), PLOD3(6), SDS(3), SHMT1(6), SHMT2(5), TMLHE(3) 16807258 210 111 197 57 62 34 26 52 36 0 0.0316 1.000 1.000 325 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH1A3(18), ALDH3A1(7), ALDH3B1(8), ALDH3B2(7), AOC2(12), AOC3(9), DDC(5), EPX(13), GOT1(6), GOT2(2), HPD(6), LPO(9), MAOA(5), MAOB(6), MPO(13), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), TAT(14), TPO(29) 11185665 183 111 157 49 78 27 18 33 27 0 0.0250 1.000 1.000 326 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), P4HB(6), SLC23A1(9), SLC23A2(17), SLC2A1(5), SLC2A3(12) 13422700 182 111 171 65 45 24 27 48 38 0 0.144 1.000 1.000 327 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 36 ACAA1(7), ACAA2(2), ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), AKR1B10(3), AKR1D1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), HSD3B7(3), LIPA(3), RDH11(3), RDH12(6), RDH13(4), RDH14(1), SLC27A5(7), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2) 15485581 209 110 194 59 55 39 33 56 25 1 0.0444 1.000 1.000 328 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 26 ATF1(5), BAD(1), CREB1(3), CREB3(5), CREB5(5), DUSP4(6), DUSP6(6), DUSP9(9), EEF2K(10), MAP2K2(2), MAP3K8(4), MAPK1(3), MAPK3(3), MKNK1(2), MKNK2(6), MOS(8), NFKB1(8), RAP1A(1), RPS6KA1(9), RPS6KA2(22), RPS6KA3(13), SHC1(13), SOS1(11), SOS2(15), TRAF3(10) 13838529 180 110 164 63 50 37 23 31 38 1 0.461 1.000 1.000 329 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 24 AKT1(11), CABIN1(22), CALM2(1), CALM3(1), CAMK1G(5), HDAC5(13), IGF1(6), IGF1R(17), INSR(20), MAP2K6(4), MAPK14(7), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NFATC2(10), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYT1(14), YWHAH(3) 13933159 181 109 171 75 58 41 21 38 23 0 0.688 1.000 1.000 330 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(48), GRIN2B(32), GRIN2C(9), GRIN2D(6), NOS1(23), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), SYT1(14) 12815583 197 109 183 90 67 40 15 42 33 0 0.935 1.000 1.000 331 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(6), CDC34(2), CDK2(5), CUL1(16), RB1(123), TFDP1(10) 3556469 162 108 116 55 25 59 9 36 25 8 0.326 1.000 1.000 332 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 23 AKT1(11), AKT2(7), AKT3(7), CISH(2), IARS(9), IL13RA1(5), IL2RG(8), IL4(5), IL4R(6), INPP5D(8), JAK1(20), JAK3(27), PI3(2), PPP1R13B(9), RPS6KB1(9), SERPINA4(5), SHC1(13), SOS1(11), SOS2(15), SRC(3), STAT6(4), TYK2(5) 15995435 191 108 172 59 51 33 22 41 43 1 0.417 1.000 1.000 333 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 24 AKT1(11), AKT2(7), AKT3(7), ANKRD6(12), AXIN1(8), CER1(4), CSNK1A1(3), DACT1(18), DKK1(8), DKK3(7), DKK4(5), FSTL1(9), GSK3A(6), GSK3B(16), LRP1(49), MVP(10), NKD1(6), PIN1(2), PSEN1(3), PTPRA(5), SENP2(3), SFRP1(2), TSHB(1), WIF1(5) 14677218 207 108 197 76 78 35 22 38 33 1 0.563 1.000 1.000 334 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(12), AGT(10), AGTR1(12), CMA1(1), COL4A1(24), COL4A2(16), COL4A3(12), COL4A4(24), COL4A5(32), COL4A6(25), REN(8) 13166602 176 107 171 58 41 26 25 47 37 0 0.0952 1.000 1.000 335 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 25 AACS(7), ABAT(8), ACADS(3), ACAT1(7), ACAT2(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH5A1(8), ALDH9A1(4), ECHS1(3), EHHADH(13), GAD1(15), GAD2(15), HADHA(10), L2HGDH(3), OXCT1(3), PDHA1(7), PDHA2(14), PDHB(3), SDHB(3), SDS(3) 12441010 191 107 174 51 56 33 26 50 26 0 0.0229 1.000 1.000 336 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 17 DIAPH1(7), FYN(15), GSN(4), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PTK2(24), PXN(2), ROCK1(27), SHC1(13), SRC(3), TLN1(21) 15064381 181 107 156 65 42 27 26 38 42 6 0.743 1.000 1.000 337 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 42 ALDOA(2), ALDOC(1), DLAT(7), DLD(3), ENO1(3), ENO2(2), ENO3(5), FBP1(1), FBP2(4), G6PC(4), GAPDH(2), GAPDHS(3), GCK(3), GOT1(6), GOT2(2), GPI(5), HK1(13), HK2(6), HK3(17), LDHA(10), LDHAL6B(6), LDHB(5), LDHC(4), MDH1(8), MDH2(3), PC(12), PCK1(3), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PFKL(7), PFKM(2), PFKP(15), PGAM1(4), PGAM2(4), PGK1(3), PGK2(9), PKLR(11), PKM2(4), TNFAIP1(4), TPI1(3) 20765388 233 107 217 98 91 38 23 47 34 0 0.857 1.000 1.000 338 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(10), POLA2(5), POLB(4), POLD1(18), POLD2(2), POLD3(14), POLE(37), POLE2(5), POLE3(1), POLG(8), POLG2(4), POLH(13), POLK(9), POLM(11), POLQ(37), PRIM1(5), PRIM2(2), REV1(13), REV3L(36), RFC5(6) 21027386 240 107 220 77 54 38 32 65 50 1 0.582 1.000 1.000 339 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ABP1(4), ACY1(5), ADC(3), AGMAT(3), ALDH18A1(8), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH7A1(6), ALDH9A1(4), AMD1(3), AOC2(12), AOC3(9), ARG1(2), ARG2(5), ASL(3), ASS1(4), CPS1(31), GATM(2), MAOA(5), MAOB(6), NAGS(5), ODC1(5), OTC(14), SAT1(4), SAT2(1), SMS(4), SRM(1) 14757811 192 106 173 60 58 41 25 45 23 0 0.181 1.000 1.000 340 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(23), C5(20), C6(24), C7(10), ICAM1(4), IL1A(1), IL6(5), IL8(5), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELP(13), TNF(1), VCAM1(12) 12311973 178 106 170 62 58 27 20 38 34 1 0.336 1.000 1.000 341 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(68), EP300(42), LPL(12), NCOA1(13), NCOA2(21), PPARG(4), RXRA(8) 9283947 168 106 157 77 40 47 27 32 22 0 0.910 1.000 1.000 342 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CREBBP(68), EP300(42), FADD(1), HDAC3(3), IKBKB(7), IKBKG(2), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 10714589 158 106 146 69 43 46 20 24 25 0 0.852 1.000 1.000 343 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), DAG1(8), ITPKA(3), ITPKB(14), ITPR1(41), ITPR2(41), ITPR3(39), NFAT5(6), PDE6A(12), PDE6B(11), PDE6C(10), PDE6D(2), SLC6A13(9), TF(16) 17658234 238 106 234 84 75 43 28 51 41 0 0.328 1.000 1.000 344 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(3), NFYB(2), NFYC(10), RB1(123), SP1(6), SP3(10) 3561443 154 106 109 50 18 64 10 34 20 8 0.114 1.000 1.000 345 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 33 ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(2), ENPP7(2), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(5), SGMS2(6), SGPP1(6), SGPP2(4), SMPD1(9), SMPD2(3), SMPD3(4), SMPD4(8), SPHK1(2), SPHK2(5), SPTLC1(11), SPTLC2(9), UGCG(9), UGT8(10) 16365010 211 105 203 73 62 36 32 49 32 0 0.286 1.000 1.000 346 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 30 APAF1(23), BCL2(2), BID(2), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CFLAR(2), CYCS(1), DFFA(4), DFFB(2), FADD(1), GAS2(4), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), SPTAN1(25), TNFRSF10A(8), TNFRSF10B(4), TNFRSF25(2), TNFSF10(2), TNFSF12(2), TRAF2(8) 16231836 178 103 161 67 38 38 22 42 37 1 0.811 1.000 1.000 347 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(7), ACAT2(8), ACOT11(9), ACYP1(1), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ECHS1(3), EHHADH(13), ESCO1(16), ESCO2(13), FN3K(1), GCDH(6), HADHA(10), ITGB1BP3(1), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5), YOD1(3) 13158598 178 103 161 60 47 35 23 38 34 1 0.477 1.000 1.000 348 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(5), ARSB(10), FUCA1(5), FUCA2(4), GALNS(6), GBA(4), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NAGLU(5), NEU1(6), NEU2(6), NEU3(2), SPAM1(9) 16510767 213 103 202 70 65 52 20 52 24 0 0.229 1.000 1.000 349 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 16 CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), INSR(20), IRS1(17), JUN(2), MAPK3(3), MAPK8(11), PTPN11(31), RASA1(20), SHC1(13), SLC2A4(7), SOS1(11), SRF(4) 9469933 158 103 135 57 38 37 21 34 27 1 0.633 1.000 1.000 350 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(68), EP300(42), ESR1(20), MAPK1(3), MAPK3(3), PELP1(11), SRC(3) 7678049 150 103 140 68 40 38 19 29 24 0 0.920 1.000 1.000 351 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(12), EPHA4(20), EPHB1(33), FYN(15), ITGA1(12), ITGB1(12), L1CAM(14), LYN(13), RAP1B(2), SELP(13) 7982869 146 102 134 47 44 31 27 28 15 1 0.0971 1.000 1.000 352 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(8), CALCRL(7), CD97(10), CRHR1(4), CRHR2(5), ELTD1(11), EMR1(13), EMR2(7), GHRHR(2), GIPR(1), GLP1R(6), GLP2R(8), GPR64(17), LPHN1(19), LPHN2(26), LPHN3(26), SCTR(5), VIPR1(6), VIPR2(11) 13892229 196 102 192 84 61 31 19 60 25 0 0.849 1.000 1.000 353 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(12), ACO1(11), ACO2(7), CLYBL(6), CS(2), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), OGDHL(12), PC(12), PCK1(3), PCK2(6), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1) 14983809 160 102 151 54 55 22 26 35 22 0 0.274 1.000 1.000 354 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(7), ARG1(2), ARG2(5), ASL(3), ASS1(4), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), DAO(7), EPRS(23), GAMT(6), GATM(2), GLUD1(4), GOT1(6), GOT2(2), LAP3(3), NOS1(23), NOS3(21), OAT(3), OTC(14), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(5), RARS(7), RARS2(7) 17466364 206 102 190 68 66 31 33 43 33 0 0.356 1.000 1.000 355 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 16 CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), IL6(5), IL6R(7), IL6ST(14), JAK1(20), JAK3(27), JUN(2), MAPK3(3), PTPN11(31), SHC1(13), SOS1(11), SRF(4), STAT3(10) 9510024 166 102 130 49 37 43 23 31 31 1 0.248 1.000 1.000 356 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 ALOX12(3), ALOX15(4), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(10), EPX(13), LPO(9), LTA4H(2), MPO(13), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PRDX1(2), PRDX2(2), PRDX5(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11), TPO(29) 13695641 186 102 175 63 78 27 23 36 22 0 0.234 1.000 1.000 357 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 28 B4GALT5(4), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(4), GALNT13(19), GALNT14(13), GALNT2(10), GALNT3(15), GALNT5(14), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GALNTL1(9), GALNTL2(10), GALNTL4(4), GALNTL5(14), GCNT1(7), GCNT3(4), GCNT4(12), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(5) 16246956 208 101 200 88 66 30 29 52 31 0 0.960 1.000 1.000 358 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(12), CAPN1(2), CAPN2(8), CAPNS1(4), CAPNS2(4), CXCR3(4), EGF(7), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), MYL2(2), MYLK(29), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PTK2(24), PXN(2), TLN1(21) 15734647 178 101 173 69 48 38 29 37 25 1 0.560 1.000 1.000 359 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(9), ABAT(8), ADSL(13), ADSS(5), AGXT(8), AGXT2(8), ASL(3), ASNS(3), ASPA(6), CAD(20), CRAT(10), DARS(4), DDO(6), GAD1(15), GAD2(15), GOT1(6), GOT2(2), GPT(6), GPT2(4), NARS(4), PC(12) 13176927 167 100 155 58 55 22 26 41 23 0 0.425 1.000 1.000 360 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(12), ACE2(12), AGT(10), AGTR1(12), ANPEP(16), CMA1(1), CPA3(4), CTSA(6), CTSG(4), ENPEP(22), LNPEP(21), MAS1(2), MME(23), NLN(10), REN(8), THOP1(6) 10428646 169 100 156 44 37 33 24 42 33 0 0.0452 1.000 1.000 361 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(10), ADRBK2(8), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CLCA1(12), CLCA2(8), CLCA4(14), CNGA3(14), CNGA4(13), CNGB1(15), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(2), PDC(4), PDE1C(17), PRKACA(1), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(10), PRKX(3) 16096741 196 100 190 91 56 30 28 50 32 0 0.960 1.000 1.000 362 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(11), BAIAP2(6), CASP1(6), CASP3(3), CASP7(3), CASP8(19), GAPDH(2), INSR(20), ITCH(7), MAGI1(27), MAGI2(25), RERE(15), WWP1(18), WWP2(8) 12050699 170 100 158 64 47 26 27 35 34 1 0.700 1.000 1.000 363 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 IFNA1(7), IFNB1(6), IKBKB(7), IL1A(1), IL1B(4), IL1R1(6), IL1RAP(5), IL1RN(6), IL6(5), IRAK1(6), IRAK2(11), IRAK3(9), JUN(2), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP3K7(7), MAPK14(7), MAPK8(11), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1), TOLLIP(5), TRAF6(4) 14135638 177 100 170 54 58 26 21 46 26 0 0.219 1.000 1.000 364 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 25 CALM2(1), CALM3(1), EGR2(14), EGR3(6), GNAQ(10), MAP3K1(18), MYC(5), NFATC2(10), NFKB1(8), NFKBIA(1), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RELA(9), SYT1(14), VIP(3), VIPR2(11) 12624877 171 100 159 59 49 37 22 32 31 0 0.356 1.000 1.000 365 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(3), AKR1B10(3), ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), FUK(9), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), HSD3B7(3), KHK(4), LHPP(5), MPI(4), MTMR1(12), MTMR2(7), MTMR6(9), PFKFB1(12), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(7), PFKM(2), PFKP(15), PGM2(3), PHPT1(2), PMM1(3), PMM2(2), RDH11(3), RDH12(6), RDH13(4), RDH14(1), TPI1(3), TSTA3(1) 18393853 200 99 189 82 81 29 22 38 30 0 0.759 1.000 1.000 366 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 15 CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), IGF1(6), IGF1R(17), IRS1(17), JUN(2), MAPK3(3), MAPK8(11), PTPN11(31), RASA1(20), SHC1(13), SOS1(11), SRF(4) 9113019 154 99 132 52 39 34 17 32 31 1 0.536 1.000 1.000 367 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 25 BIRC2(5), BIRC3(11), CASP3(3), CASP8(19), CFLAR(2), FADD(1), IKBKG(2), JUN(2), MAP3K3(6), MAP3K7(7), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), NR2C2(11), RALBP1(6), RIPK1(7), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 12201962 157 99 138 50 34 45 13 30 35 0 0.348 1.000 1.000 368 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 24 ACAA1(7), ACAA2(2), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH6(8), ADH7(7), ADHFE1(8), AKR1D1(8), ALDH1A1(11), ALDH1A3(18), ALDH1B1(8), ALDH3A1(7), ALDH3A2(10), ALDH9A1(4), BAAT(3), CEL(12), CYP27A1(4), CYP7A1(13), HADHB(9), SOAT2(4), SRD5A1(2), SRD5A2(2) 10636745 163 98 150 37 39 32 25 45 21 1 0.00569 1.000 1.000 369 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(7), CS(2), DLAT(7), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), OGDH(13), PC(12), PDHA1(7), PDHA2(14), PDHB(3), PDHX(3), PDK1(5), PDK2(8), PDK3(5), PDK4(4), PDP2(5), SDHA(12), SDHB(3), SDHD(4), SUCLA2(6), SUCLG1(2), SUCLG2(1) 14714864 171 98 157 65 55 28 26 36 26 0 0.566 1.000 1.000 370 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 26 DUSP1(6), IKBKG(2), MAPK1(3), MAPK10(14), MAPK12(4), MAPK13(4), MAPK14(7), MAPK3(3), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10), MAPKAPK5(6), NFKB1(8), NFKB2(4), NFKBIA(1), NFKBIB(5), NFKBIE(4), PIK3CD(10), SYT1(14), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4) 11815772 165 98 147 51 51 40 18 34 22 0 0.161 1.000 1.000 371 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(12), ACTN1(9), ACTN2(15), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(12), ITGB3(12), PTK2(24), PXN(2), RAC1(2), SPTAN1(25), SRC(3), TLN1(21) 14529895 165 98 159 88 52 30 19 40 22 2 0.998 1.000 1.000 372 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(4), CSF1R(15), DDX20(6), E2F4(2), ETS1(6), ETS2(4), ETV3(4), FOS(4), HDAC2(8), HDAC5(13), HRAS(4), JUN(2), NCOR2(38), RBL1(18), RBL2(22), SIN3A(20), SIN3B(9) 12922974 179 97 160 69 46 33 17 35 48 0 0.892 1.000 1.000 373 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(7), CDK7(3), ERCC3(18), GTF2A2(1), GTF2E1(13), GTF2E2(1), GTF2H1(4), GTF2H4(3), ILK(3), MNAT1(3), POLR1A(12), POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3B(8), POLR3D(5), POLR3E(10), POLR3H(2), POLR3K(1), TAF12(3), TAF13(3), TAF5(11), TAF6(8), TAF7(2), TAF9(2), TBP(2) 17969059 172 97 163 72 41 33 26 40 32 0 0.937 1.000 1.000 374 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 19 BTK(11), DLG4(10), EPHB2(15), F2(9), F2RL2(6), JUN(2), MAP2K5(4), MAPK1(3), MAPK7(6), MAPK8(11), MYEF2(14), PLD1(16), PLD2(7), PLD3(7), PTK2(24), RASAL1(7), SRC(3), TEC(8), VAV1(22) 12980325 185 97 179 71 62 38 24 38 23 0 0.656 1.000 1.000 375 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C8B(22), C9(11), MASP1(19) 12608648 173 96 161 59 50 22 21 39 39 2 0.662 1.000 1.000 376 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(3), ACAD9(6), ADH1A(4), ADH1B(7), ADH1C(4), ADH4(1), ADH5(6), ADH6(8), ADH7(7), ADHFE1(8), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5) 12636124 170 95 152 66 38 41 23 42 25 1 0.747 1.000 1.000 377 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(22), CALM2(1), CALM3(1), CAPN2(8), CAPNS1(4), CAPNS2(4), EP300(42), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(10), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SYT1(14) 11515991 145 95 132 65 39 31 21 26 28 0 0.911 1.000 1.000 378 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 35 ARNTL(11), AZIN1(3), BTG1(2), CBX3(6), CRY2(5), DNAJA1(4), EIF4G2(16), ETV6(10), GFRA1(12), GSTM3(5), GSTP1(1), HERPUD1(3), HSPA8(11), IDI1(4), KLF9(1), MYF6(6), NCKAP1(15), NCOA4(8), NR1D2(7), PER1(12), PER2(7), PIGF(1), PPP1R3C(4), PPP2CB(2), PSMA4(3), SF3A3(1), SUMO3(1), TUBB3(8), UCP3(3), UGP2(10), VAPA(2), ZFR(15) 16857784 199 94 180 61 64 28 20 45 41 1 0.392 1.000 1.000 379 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 26 AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CFLAR(2), CRKL(5), FOS(4), HRAS(4), IL2RA(3), IL2RB(4), IL2RG(8), IRS1(17), JAK1(20), JAK3(27), MAPK1(3), MAPK3(3), MYC(5), NMI(3), PPIA(1), PTPN6(4), RPS6KB1(9), SHC1(13), SOS1(11), STAT5A(8), SYK(5) 13111401 174 94 150 54 46 31 26 31 39 1 0.356 1.000 1.000 380 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 24 BCAR1(5), CALM2(1), CALM3(1), CRKL(5), GNAQ(10), HRAS(4), JUN(2), MAP2K2(2), MAP2K3(8), MAP3K1(18), MAPK1(3), MAPK14(7), MAPK3(3), MAPK8(11), PAK1(10), PLCG1(17), PRKCA(5), PTK2B(13), RAC1(2), SHC1(13), SOS1(11), SRC(3), SYT1(14) 12545922 168 94 153 67 36 34 17 49 31 1 0.940 1.000 1.000 381 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(23), ARHGDIB(5), BIRC2(5), BIRC3(11), CASP1(6), CASP10(7), CASP2(8), CASP3(3), CASP4(8), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), GZMB(4), LMNB1(9), LMNB2(2), PRF1(7) 9933116 134 93 116 51 24 32 11 36 31 0 0.902 1.000 1.000 382 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(5), DAB1(13), FYN(15), LRP8(1), RELN(83), VLDLR(13) 7325732 132 93 109 41 35 35 16 27 19 0 0.0713 1.000 1.000 383 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(66), MAP2(51), PPP1CA(2), PPP2CA(3), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4), PRKCE(4) 9497583 149 92 132 48 30 33 20 33 33 0 0.402 1.000 1.000 384 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 FADD(1), IKBKB(7), IKBKG(2), IL1A(1), IL1R1(6), IRAK1(6), MAP3K1(18), MAP3K14(6), MAP3K7(7), MYD88(3), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TLR4(15), TNF(1), TNFAIP3(39), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 11340662 146 92 138 51 34 40 16 31 25 0 0.449 1.000 1.000 385 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(39), APOA1(3), APOA4(4), APOC2(1), APOE(1), CETP(11), CYP7A1(13), DGAT1(5), HMGCR(6), LCAT(4), LDLR(9), LIPC(5), LPL(12), LRP1(49), SCARB1(3), SOAT1(6) 13528722 171 92 161 64 55 29 23 43 21 0 0.571 1.000 1.000 386 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(9), CARS(10), DARS(4), EPRS(23), FARS2(5), GARS(8), HARS(6), IARS(9), KARS(8), LARS(12), LARS2(5), MARS(12), MARS2(5), NARS(4), QARS(13), RARS(7), SARS(5), TARS(7), WARS(3), WARS2(6), YARS(4) 17070398 165 91 160 36 54 23 25 40 23 0 0.0126 1.000 1.000 387 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 19 CSNK2A1(7), EGF(7), ELK1(4), FOS(4), HRAS(4), JAK1(20), JUN(2), MAP3K1(18), MAPK3(3), MAPK8(11), PLCG1(17), PRKCA(5), RASA1(20), SHC1(13), SOS1(11), SRF(4), STAT1(15), STAT3(10), STAT5A(8) 14375051 183 91 168 62 50 31 18 42 41 1 0.739 1.000 1.000 388 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(10), CHIT1(10), CMAS(6), CTBS(6), CYB5R1(2), CYB5R3(1), GFPT1(5), GFPT2(11), GNE(7), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NAGK(7), NANS(1), NPL(3), PGM3(5), PHPT1(2), RENBP(3), UAP1(6) 14792435 170 91 164 47 61 33 19 32 25 0 0.0594 1.000 1.000 389 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(13), GLI2(22), GLI3(37), GSK3B(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SHH(3), SMO(11), SUFU(5) 7885736 140 91 129 62 54 30 13 21 22 0 0.725 1.000 1.000 390 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), LTA(1), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNFAIP3(39), TNFRSF1B(1), TRAF1(5), TRAF2(8), TRAF3(10) 10847205 148 91 135 51 38 42 17 22 29 0 0.310 1.000 1.000 391 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1D1(8), ARSB(10), ARSD(9), ARSE(4), CYP11B1(13), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(6), HSD17B3(4), HSD17B8(5), HSD3B1(5), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(11), SULT1E1(5), SULT2A1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9) 13664275 168 90 155 48 61 23 20 27 37 0 0.0606 1.000 1.000 392 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11), MASP1(19), MASP2(10), MBL2(3) 12875350 164 90 153 60 45 18 21 38 40 2 0.820 1.000 1.000 393 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 22 ADCY1(22), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CREB1(3), HRAS(4), MAPK1(3), MAPK14(7), MAPK3(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5), RAC1(2), RPS6KA1(9), RPS6KA5(10), SOS1(11) 11762516 141 90 136 54 46 33 18 27 17 0 0.470 1.000 1.000 394 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 18 CSNK2A1(7), ELK1(4), FOS(4), HRAS(4), IL2(4), IL2RA(3), IL2RB(4), IL2RG(8), JAK1(20), JAK3(27), JUN(2), LCK(8), MAPK3(3), MAPK8(11), SHC1(13), SOS1(11), STAT5A(8), SYK(5) 9735237 146 90 126 46 36 35 13 28 33 1 0.516 1.000 1.000 395 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 21 ASAH1(4), CAMP(1), CASP3(3), CERK(3), CREB1(3), CREB3(5), CREB5(5), DAG1(8), EPHB2(15), FOS(4), GNAQ(10), ITPKA(3), ITPKB(14), JUN(2), MAPK1(3), MAPK10(14), MAPK8(11), MAPK8IP1(5), MAPK8IP3(11), MAPK9(10) 9534223 134 90 130 48 37 25 17 32 23 0 0.424 1.000 1.000 396 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 15 ADCY1(22), ARHGEF1(13), F2(9), F2R(11), GNA12(6), GNA13(3), GNAI1(3), GNAQ(10), GNB1(3), MAP3K7(7), PLCB1(22), PRKCA(5), PTK2B(13), ROCK1(27) 10108707 154 89 135 64 47 31 10 34 28 4 0.960 1.000 1.000 397 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(11), EEA1(15), GRASP(3), GSK3A(6), GSK3B(16), LYN(13), PDPK1(4), PFKL(7), PFKM(2), PFKP(15), PLCG1(17), PRKCE(4), PRKCZ(3), RAB5A(3), RAC1(2), RPS6KB1(9) 11593177 154 89 144 45 49 33 22 21 28 1 0.116 1.000 1.000 398 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(13), GABRA1(15), GABRA2(14), GABRA3(6), GABRA4(19), GABRA5(18), GABRA6(20), GPHN(16), NSF(4), SRC(3), UBQLN1(6) 6376004 134 88 124 46 33 20 14 43 24 0 0.468 1.000 1.000 399 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(7), AMD1(3), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTAP(2), MTFMT(1), MTR(13), SRM(1), TAT(14) 10647886 142 88 131 48 54 21 18 25 23 1 0.343 1.000 1.000 400 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 17 CCL11(1), CCR3(9), CFL1(2), GNAQ(10), GNB1(3), HRAS(4), LIMK1(7), MAPK1(3), MAPK3(3), MYL2(2), NOX1(4), PIK3C2G(19), PLCB1(22), PRKCA(5), PTK2(24), ROCK2(15) 9719944 133 87 125 53 33 30 12 36 21 1 0.849 1.000 1.000 401 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 33 ANPEP(16), G6PD(12), GCLC(8), GCLM(3), GPX1(4), GPX2(3), GPX3(2), GPX4(1), GPX5(6), GPX6(9), GPX7(1), GSR(5), GSS(8), GSTA1(6), GSTA2(2), GSTA3(6), GSTA4(2), GSTA5(6), GSTM1(1), GSTM2(3), GSTM3(5), GSTM4(5), GSTO2(2), GSTP1(1), GSTT1(2), GSTZ1(4), IDH2(16), MGST1(2), MGST2(2), MGST3(1), TXNDC12(1) 9385134 145 87 130 36 32 28 23 40 22 0 0.0184 1.000 1.000 402 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), BLVRB(1), CP(18), CPOX(3), EPRS(23), FECH(3), GUSB(4), HCCS(2), HMBS(4), HMOX1(6), HMOX2(3), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9), UROD(2), UROS(5) 14137647 148 87 129 41 38 26 18 30 36 0 0.343 1.000 1.000 403 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 18 F2(9), F2R(11), GNAI1(3), GNB1(3), HRAS(4), ITGA1(12), ITGB1(12), MAPK1(3), MAPK3(3), PLA2G4A(13), PLCB1(22), PRKCA(5), PTGS1(9), PTK2(24), SRC(3), SYK(5), TBXAS1(11) 11545298 152 87 140 71 48 36 20 33 15 0 0.947 1.000 1.000 404 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 17 ADCY1(22), AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(17), IL3(6), KITLG(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), YWHAH(3) 7528590 110 86 102 38 45 26 6 19 14 0 0.282 1.000 1.000 405 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 16 CALM2(1), CALM3(1), CDKN1A(2), GNAQ(10), NFATC2(10), NFATC3(13), NFATC4(11), PLCG1(17), PPP3CA(3), PPP3CB(10), PPP3CC(5), PRKCA(5), SP1(6), SP3(10), SYT1(14) 9788005 118 86 107 53 32 30 13 23 20 0 0.909 1.000 1.000 406 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 11 ACTN1(9), ACTN2(15), ACTN3(6), BCAR1(5), CSK(3), CTNNA1(26), CTNNA2(33), PTK2(24), PXN(2), SRC(3), VCL(9) 8449723 135 86 127 55 49 20 12 33 20 1 0.715 1.000 1.000 407 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 20 AKT1(11), AXIN1(8), CCND1(2), CD14(6), FZD1(7), GJA1(5), GNAI1(3), GSK3B(16), IRAK1(6), LBP(7), LEF1(9), LY96(4), MYD88(3), NFKB1(8), PDPK1(4), PPP2CA(3), RELA(9), TIRAP(5), TLR4(15), TOLLIP(5) 8603640 136 86 129 42 41 35 18 19 22 1 0.107 1.000 1.000 408 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 19 BCAR1(5), CXCL12(2), CXCR4(6), GNAI1(3), GNAQ(10), GNB1(3), HRAS(4), MAPK1(3), MAPK3(3), NFKB1(8), PIK3C2G(19), PLCG1(17), PRKCA(5), PTK2(24), PTK2B(13), PXN(2), RELA(9) 10670926 136 85 129 66 34 32 15 31 23 1 0.985 1.000 1.000 409 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(1), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(39), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(9), SMPD2(3), SPTLC1(11), SPTLC2(9), UGCG(9) 11380855 154 85 146 52 45 27 21 42 19 0 0.317 1.000 1.000 410 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(4), ALOX5(12), CYP1A2(10), CYP2C18(7), CYP2C19(11), CYP2C8(9), CYP2C9(8), CYP2E1(9), CYP2J2(3), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), HSD3B7(3), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), RDH11(3), RDH12(6), RDH13(4), RDH14(1) 12588066 151 85 145 53 50 33 18 38 11 1 0.306 1.000 1.000 411 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(12), ADCY1(22), CAP1(4), CCNB1(8), CDC25C(5), GNAI1(3), GNB1(3), HRAS(4), MAPK1(3), MAPK3(3), MYT1(20), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), RPS6KA1(9), SRC(3) 9276848 126 85 121 43 51 25 17 23 10 0 0.135 1.000 1.000 412 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(5), CSNK1D(14), DRD1(9), DRD2(7), GRM1(32), PLCB1(22), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 8141009 125 84 113 46 40 32 7 27 19 0 0.566 1.000 1.000 413 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 17 GH1(4), GHR(12), HRAS(4), INSR(20), IRS1(17), MAPK1(3), MAPK3(3), PLCG1(17), PRKCA(5), PTPN6(4), RPS6KA1(9), SHC1(13), SLC2A4(7), SOS1(11), SRF(4), STAT5A(8) 11360433 141 84 127 67 41 25 21 31 22 1 0.981 1.000 1.000 414 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 17 AADAC(5), ABP1(4), AOC2(12), AOC3(9), CES1(13), ESCO1(16), ESCO2(13), LIPA(3), MYST3(28), MYST4(25), NAT6(2), PLA1A(8), PNPLA3(6), PPME1(2), PRDX6(4), SH3GLB1(5) 12297191 155 84 142 61 43 29 19 36 27 1 0.773 1.000 1.000 415 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(4), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), DDOST(4), DPAGT1(12), DPM1(3), FUT8(10), MAN1A1(12), MAN1B1(7), MGAT1(7), MGAT3(11), MGAT4A(6), MGAT4B(7), MGAT5(14), RPN1(4), RPN2(6), ST6GAL1(3) 9567334 136 84 122 43 39 29 17 27 24 0 0.499 1.000 1.000 416 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 ERCC3(18), GTF2A1(5), GTF2E1(13), GTF2F1(5), HDAC3(3), NCOA1(13), NCOA2(21), NCOA3(14), NCOR2(38), POLR2A(12), RARA(5), RXRA(8), TBP(2) 11893944 157 84 142 76 44 27 26 29 31 0 0.994 1.000 1.000 417 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(23), BIRC2(5), BIRC3(11), CASP10(7), CASP3(3), CASP7(3), CASP8(19), CASP9(5), DFFA(4), DFFB(2), GZMB(4), PRF1(7), SCAP(6), SREBF1(8), SREBF2(9) 8877382 116 84 102 44 25 20 13 31 27 0 0.808 1.000 1.000 418 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(10), F13A1(12), F2(9), F2R(11), FGA(19), FGB(4), FGG(7), PLAT(10), PLAU(6), PLG(23), SERPINB2(9), SERPINE1(8) 7190582 128 83 120 52 31 23 22 31 21 0 0.838 1.000 1.000 419 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 26 ATG3(2), ATG7(1), BECN1(2), GABARAPL1(1), IFNA1(7), IFNA10(3), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(4), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(25), PIK3R4(20), PRKAA1(8), PRKAA2(15), ULK2(14), ULK3(3) 9741846 138 83 126 41 23 31 21 42 20 1 0.290 1.000 1.000 420 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(1), CCR1(7), CCR2(7), CCR3(9), CCR4(2), CCR5(11), CCR7(5), CD28(4), CD4(4), CXCR3(4), CXCR4(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18R1(13), IL2(4), IL4(5), IL4R(6), TGFB1(2), TGFB2(6), TGFB3(2) 10650676 133 83 123 57 28 30 17 39 18 1 0.850 1.000 1.000 421 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(5), CREBBP(68), DFFA(4), DFFB(2), GZMA(8), GZMB(4), HMGB2(2), NME1(1), PRF1(7), SET(6) 5419971 108 83 103 46 29 25 14 23 17 0 0.796 1.000 1.000 422 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(11), ACO2(7), CS(2), DLD(3), DLST(3), FH(9), IDH2(16), IDH3A(2), IDH3G(4), MDH1(8), MDH2(3), PC(12), PCK1(3), SDHA(12), SDHB(3), SUCLA2(6), SUCLG1(2), SUCLG2(1) 10145375 107 82 100 40 34 16 17 24 16 0 0.501 1.000 1.000 423 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UGDH(8), UGP2(10), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2A1(11), UGT2A3(13), UGT2B10(2), UGT2B11(10), UGT2B15(3), UGT2B17(4), UGT2B28(11), UGT2B4(9), UGT2B7(7), XYLB(6) 13427435 161 82 145 42 31 26 19 43 42 0 0.281 1.000 1.000 424 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(6), IKBKAP(15), IKBKB(7), IKBKG(2), MAP3K1(18), MAP3K14(6), NFKB1(8), NFKBIA(1), RELA(9), TNFAIP3(39), TRAF3(10), TRAF6(4) 8778194 125 81 115 40 31 34 13 21 26 0 0.288 1.000 1.000 425 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 21 CALM2(1), CALM3(1), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), HDAC5(13), MEF2A(5), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(3), PPP3CB(10), PPP3CC(5), SLC2A4(7), SYT1(14), YWHAH(3) 9687724 124 81 117 59 37 28 10 26 23 0 0.948 1.000 1.000 426 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 8 CSF1R(15), EGF(7), PDGFRA(56), PRKCA(5), SH3GLB1(5), SH3GLB2(6), SH3KBP1(8), SRC(3) 6319723 105 80 96 52 15 34 16 28 10 2 0.945 1.000 1.000 427 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 22 ATF1(5), CASP2(8), CRADD(3), IKBKB(7), IKBKG(2), JUN(2), LTA(1), MAP2K3(8), MAP2K6(4), MAP3K1(18), MAP3K14(6), MAP4K2(5), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), RIPK1(7), TANK(5), TNF(1), TNFRSF1A(4), TRAF2(8) 10891573 130 80 123 51 38 28 17 24 23 0 0.663 1.000 1.000 428 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(4), CR1(19), CR2(20), FCGR2B(2), HLA-DRB1(6), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27) 7317534 116 79 113 40 29 16 20 25 24 2 0.559 1.000 1.000 429 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(16), CD2(7), CD33(2), CD5(7), CD7(4), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(16), TLR2(7), TLR4(15), TLR7(15), TLR9(12) 9572799 133 79 123 55 43 22 16 37 13 2 0.696 1.000 1.000 430 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), HGSNAT(7), HPSE(9), HPSE2(19), HYAL1(4), HYAL2(1), IDS(5), LCT(39), NAGLU(5), SPAM1(9) 10144481 141 79 130 44 43 33 12 36 17 0 0.228 1.000 1.000 431 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B3GALT4(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), SLC33A1(9), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(13), ST6GALNAC4(3), ST6GALNAC5(8), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(7) 7990629 119 79 108 41 43 30 12 24 10 0 0.314 1.000 1.000 432 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 AKT1(11), IL2RG(8), IL4(5), IL4R(6), IRS1(17), JAK1(20), JAK3(27), RPS6KB1(9), SHC1(13), STAT6(4) 6925196 120 79 97 32 31 22 17 16 33 1 0.245 1.000 1.000 433 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 25 AHCY(7), CARM1(3), CBS(3), CTH(5), HEMK1(1), LCMT1(1), LCMT2(6), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), METTL2B(2), METTL6(5), PAPSS1(4), PAPSS2(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), SCLY(11), SEPHS1(5), SEPHS2(5), WBSCR22(2) 12021219 131 78 128 44 37 23 18 34 19 0 0.311 1.000 1.000 434 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(18), EXT2(1), EXTL1(7), EXTL2(5), EXTL3(12), GLCE(5), HS2ST1(4), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), HS3ST5(5), HS6ST2(5), HS6ST3(6), NDST1(9), NDST2(9), NDST3(15), NDST4(13) 10448192 128 78 125 48 51 24 13 24 16 0 0.608 1.000 1.000 435 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 23 AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11) 10592944 123 78 116 48 38 23 17 23 22 0 0.775 1.000 1.000 436 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 18 CCR5(11), CD3D(4), CD3E(2), CXCR3(4), ETV5(13), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), JUN(2), MAP2K6(4), MAPK14(7), MAPK8(11), STAT4(10), TYK2(5) 8288401 114 77 105 48 22 26 19 32 15 0 0.827 1.000 1.000 437 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGAM(13), ITGB1(12), ITGB2(16), SELE(11), SELL(5), SELP(13) 8115760 111 77 110 36 38 20 11 23 19 0 0.271 1.000 1.000 438 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(3), CA4(4), CA5A(1), CA5B(2), CA6(7), CA7(5), CA8(5), CA9(11), CPS1(31), CTH(5), GLS(2), GLS2(6), GLUD1(4), GLUL(4), HAL(11) 9972928 120 77 113 45 36 23 17 23 21 0 0.712 1.000 1.000 439 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(3), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(5), EDN1(3), EDNRA(8), EDNRB(13), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(13), PRL(3), PTGDR(7), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(7), PTGIR(2), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11) 10734350 138 77 132 49 50 17 12 39 20 0 0.492 1.000 1.000 440 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 15 CSNK2A1(7), FOS(4), HRAS(4), JUN(2), MAPK3(3), MPL(5), PLCG1(17), PRKCA(5), RASA1(20), SHC1(13), SOS1(11), STAT1(15), STAT3(10), STAT5A(8), THPO(5) 10296154 129 77 116 44 32 23 11 28 34 1 0.828 1.000 1.000 441 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2B1(10), MAN2B2(7), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2) 9737081 122 76 118 43 38 32 14 28 10 0 0.357 1.000 1.000 442 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(1), COASY(3), DPYD(32), DPYS(10), ENPP1(17), ENPP3(10), ILVBL(8), PANK1(7), PANK2(1), PANK3(6), PANK4(8), PPCS(2), UPB1(7), VNN1(11) 8538602 128 76 121 34 28 26 23 37 13 1 0.0420 1.000 1.000 443 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(7), BHMT(8), CBS(3), CTH(5), DNMT1(20), DNMT3A(21), DNMT3B(14), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), MTR(13) 9000806 121 76 114 38 45 20 13 21 21 1 0.276 1.000 1.000 444 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 11 ARHGEF1(13), GNA12(6), GNA13(3), GNAQ(10), GNB1(3), MYL2(2), MYLK(29), PLCB1(22), PRKCA(5), ROCK1(27) 8234658 120 76 107 49 29 19 14 29 25 4 0.912 1.000 1.000 445 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 AANAT(2), ACHE(3), CHAT(16), DBH(8), DDC(5), GAD1(15), GAD2(15), HDC(8), MAOA(5), PAH(15), PNMT(3), SLC18A3(11), TPH1(2) 6821903 108 75 100 45 37 18 11 34 8 0 0.649 1.000 1.000 446 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 14 ADAM12(13), AGT(10), EDN1(3), EDNRA(8), EDNRB(13), EGF(7), FOS(4), HRAS(4), JUN(2), MYC(5), NFKB1(8), PLCG1(17), PRKCA(5), RELA(9) 8863891 108 75 102 46 25 19 21 21 22 0 0.878 1.000 1.000 447 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(18), AP2A1(5), AP2M1(6), BIN1(3), CALM2(1), CALM3(1), DNM1(13), EPN1(9), EPS15(11), NME1(1), PICALM(8), PPP3CA(3), PPP3CB(10), PPP3CC(5), SYNJ1(24), SYNJ2(14), SYT1(14) 11587367 146 75 133 62 38 27 16 36 29 0 0.865 1.000 1.000 448 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(2), C1QB(2), C1R(6), C1S(14), C2(6), C3(23), C4A(3), C5(20), C6(24), C7(10), C8A(11), C9(11) 10836621 132 74 121 44 37 13 16 27 37 2 0.729 1.000 1.000 449 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(9), F2R(11), F3(1), F5(30), F7(6), FGA(19), FGB(4), FGG(7), PROC(3), PROS1(9), SERPINC1(8), TFPI(6) 8417194 118 74 110 46 31 24 17 32 14 0 0.738 1.000 1.000 450 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 24 AKR1B1(3), ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), FPGT(7), GCK(3), GMDS(4), GMPPA(10), HK1(13), HK2(6), HK3(17), KHK(4), MPI(4), PFKFB1(12), PFKFB3(2), PFKFB4(5), PFKM(2), PFKP(15), PMM1(3), PMM2(2), TPI1(3) 11894894 123 74 116 53 49 18 13 24 19 0 0.808 1.000 1.000 451 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(2), AGPAT3(4), AGPAT4(8), AGPAT6(3), AGPS(5), CHPT1(3), ENPP2(23), ENPP6(10), PAFAH1B1(6), PAFAH2(6), PLA2G12A(1), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(4), PLA2G4A(13), PLA2G5(1), PLA2G6(8), PLD1(16), PLD2(7), PPAP2A(2), PPAP2B(2), PPAP2C(3) 12152391 136 74 128 61 44 27 17 32 16 0 0.944 1.000 1.000 452 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 21 ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME3(7), PGK1(3), PGK2(9), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TKTL1(7), TPI1(3) 9173363 106 74 102 40 29 13 13 37 14 0 0.658 1.000 1.000 453 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 CISH(2), IL6(5), IL6R(7), JAK1(20), JAK3(27), PIAS3(10), PTPRU(18), REG1A(6), SRC(3), STAT3(10) 6550148 108 74 94 35 39 21 19 13 16 0 0.228 1.000 1.000 454 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 12 CD28(4), CD3D(4), CD3E(2), CD80(4), CD86(2), CTLA4(4), HLA-DRB1(6), ICOS(2), IL2(4), ITK(21), LCK(8), PTPN11(31) 4043053 92 73 75 30 14 35 11 20 10 2 0.453 1.000 1.000 455 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 14 AKT1(11), CREB1(3), HRAS(4), MAPK1(3), MAPK3(3), MAPK7(6), MEF2A(5), MEF2C(15), MEF2D(3), NTRK1(16), PLCG1(17), RPS6KA1(9), SHC1(13) 7476989 108 73 100 44 31 22 17 17 20 1 0.849 1.000 1.000 456 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(12), BST1(2), C9orf95(2), CD38(4), ENPP1(17), ENPP3(10), NADK(5), NADSYN1(4), NMNAT1(2), NMNAT2(4), NMNAT3(4), NNMT(4), NNT(5), NT5C(1), NT5C1A(6), NT5C1B(12), NT5C2(10), NT5C3(5), NT5E(6), NT5M(3), NUDT12(3), QPRT(2) 11397771 123 73 117 42 37 26 16 29 14 1 0.219 1.000 1.000 457 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(6), FOS(4), GNAQ(10), JUN(2), MAPK14(7), MAPK8(11), PLCG1(17), PRKCA(5), PTK2B(13), SYT1(14) 7104158 105 72 95 46 21 27 9 31 17 0 0.953 1.000 1.000 458 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), CDC42(2), PAK1(10), PDGFRA(56), RAC1(2), WASL(16) 5171551 112 72 100 39 20 29 16 32 13 2 0.473 1.000 1.000 459 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), CMBL(1), CYP3A4(9), CYP3A43(3), CYP3A5(3), CYP3A7(9), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), PON1(11), PON2(6), PON3(10) 8728048 124 72 115 40 33 29 13 28 20 1 0.310 1.000 1.000 460 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(11), BAD(1), CHRNB1(10), CHRNG(6), MUSK(13), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(8), YWHAH(3) 6139996 97 71 90 38 27 22 13 18 17 0 0.671 1.000 1.000 461 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 20 ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), GOT1(6), GOT2(2), GPT(6), GPT2(4), MDH1(8), MDH2(3), ME1(11), ME2(9), ME3(7), PGK1(3), PKLR(11), PKM2(4), RPE(4), RPIA(4), TKT(6), TPI1(3) 8714284 99 71 95 32 25 14 14 32 14 0 0.329 1.000 1.000 462 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 16 BAD(1), BCL2(2), CASP8(19), CYCS(1), FADD(1), MAP3K1(18), MAPK1(3), MAPK3(3), MAPK8(11), NFKB1(8), NSMAF(10), RELA(9), RIPK1(7), SMPD1(9), TNFRSF1A(4), TRAF2(8) 8626706 114 71 107 33 35 22 10 22 25 0 0.156 1.000 1.000 463 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(12), PGAP1(11), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(9), PIGH(1), PIGK(10), PIGM(6), PIGN(6), PIGO(12), PIGP(1), PIGQ(6), PIGS(6), PIGT(2), PIGU(2), PIGV(3), PIGW(2), PIGX(2), PIGZ(6) 12374706 111 71 103 48 18 28 9 33 23 0 0.954 1.000 1.000 464 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), ESCO1(16), ESCO2(13), MYST3(28), MYST4(25), NAT6(2), PNPLA3(6), SH3GLB1(5) 8323582 116 71 102 46 29 26 12 26 22 1 0.850 1.000 1.000 465 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(20), ABCC2(18), ABCG2(12), CES1(13), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9) 11602723 133 71 116 49 39 24 17 26 26 1 0.598 1.000 1.000 466 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(9), ACADS(3), ACADVL(6), ACSL1(9), ACSL3(11), ACSL4(10), CPT1A(10), CPT2(2), DCI(3), EHHADH(13), HADHA(10), SCP2(6), SLC25A20(1) 8818945 97 71 90 36 25 18 14 25 15 0 0.483 1.000 1.000 467 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(12), ACTR2(1), ACTR3(4), ARPC1A(9), ARPC1B(5), ARPC2(4), ARPC3(2), ARPC4(1), NCKAP1(15), NTRK1(16), PIR(1), PSMA7(1), RAC1(2), WASF1(3), WASF2(5), WASF3(14), WASL(16) 8126706 111 70 105 38 30 13 16 32 20 0 0.534 1.000 1.000 468 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 23 ALDOA(2), ALDOC(1), DERA(4), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKL(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TALDO1(4), TKT(6), TKTL1(7) 10484024 115 69 111 48 43 13 17 30 12 0 0.695 1.000 1.000 469 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(1), IARS(9), IARS2(19), ILVBL(8), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3), VARS(7), VARS2(9) 8561493 99 69 98 34 39 17 14 14 15 0 0.478 1.000 1.000 470 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(23), BAK1(2), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(5), BIRC3(11), CASP3(3), CASP6(2), CASP7(3), CASP8(19), CASP9(5), CYCS(1), DFFA(4), DFFB(2), DIABLO(3), ENDOG(3) 6831860 92 69 80 28 17 16 13 24 22 0 0.479 1.000 1.000 471 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(5), FUCA1(5), FUCA2(4), GLB1(9), HEXA(3), HEXB(3), LCT(39), MAN2C1(11), MANBA(12), NEU1(6), NEU2(6), NEU3(2) 7949587 105 69 101 31 31 28 13 23 10 0 0.131 1.000 1.000 472 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 12 EGF(7), HRAS(4), MAPK1(3), MAPK3(3), PTPRB(19), RASA1(20), SHC1(13), SOS1(11), SPRY1(9), SPRY2(2), SPRY4(7), SRC(3) 8600961 101 69 90 33 19 22 14 21 24 1 0.637 1.000 1.000 473 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 CISH(2), JAK1(20), JAK3(27), PIAS1(4), PIAS3(10), PTPRU(18), REG1A(6), SOAT1(6) 5675504 93 69 83 29 33 20 13 11 16 0 0.253 1.000 1.000 474 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(5), ALDH18A1(8), ARG1(2), ARG2(5), ASL(3), CKM(6), CKMT1B(2), CKMT2(6), CPS1(31), GAMT(6), GATM(2), GLUD1(4), NAGS(5), OAT(3), ODC1(5), OTC(14), SMS(4) 8948451 111 69 103 32 29 26 19 24 13 0 0.125 1.000 1.000 475 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(23), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(3), CASP8(19), CASP9(5), CYCS(1), GZMB(4), JUN(2), PRF1(7) 5164230 82 68 70 30 17 16 8 19 22 0 0.774 1.000 1.000 476 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(5), B3GNT2(4), B3GNT7(6), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT4(2), CHST1(9), CHST2(11), CHST4(6), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 5473752 92 68 88 31 45 17 4 14 12 0 0.516 1.000 1.000 477 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 13 MAP3K14(6), MAPK14(7), MAPK8(11), NFKB1(8), RELA(9), TNFRSF13B(6), TNFRSF17(4), TNFSF13(2), TNFSF13B(3), TRAF2(8), TRAF3(10), TRAF5(11), TRAF6(4) 6534453 89 68 83 29 33 15 8 15 18 0 0.450 1.000 1.000 478 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(29), ABCB11(19), ABCB4(23), ABCC1(20), ABCC3(10), GSTP1(1) 7369488 102 67 105 33 18 16 16 27 23 2 0.536 1.000 1.000 479 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 12 AKT1(11), AKT2(7), AKT3(7), CDKN1A(2), ELK1(4), HRAS(4), MAP2K2(2), NGFR(4), NTRK1(16), PIK3CD(10), SHC1(13), SOS1(11) 6078525 91 67 83 40 27 10 16 19 18 1 0.906 1.000 1.000 480 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(23), C5(20), C6(24), C7(10), C8A(11), C9(11) 6634264 99 66 91 32 30 11 13 22 22 1 0.456 1.000 1.000 481 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(22), GNB1(3), PPP2CA(3), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(6), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 6886995 94 66 89 36 32 19 7 19 17 0 0.640 1.000 1.000 482 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(11), ERBB4(56), NRG2(6), NRG3(14), PRKCA(5), PSEN1(3) 4774191 95 66 88 36 17 21 18 25 14 0 0.678 1.000 1.000 483 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(4), HRAS(4), JUN(2), MAPK3(3), MAPK8(11), PLCG1(17), PTPN6(4), SHC1(13), SOS1(11), STAT5A(8) 7626760 91 65 82 38 26 15 8 19 22 1 0.952 1.000 1.000 484 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(10), GALNS(6), GLB1(9), GNS(8), GUSB(4), HEXA(3), HEXB(3), IDS(5), LCT(39), NAGLU(5) 7169816 92 65 86 30 34 19 8 22 9 0 0.218 1.000 1.000 485 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(4), ITGA4(14), ITGAL(18), ITGB1(12), ITGB2(16), SELE(11), SELL(5) 6237051 85 65 82 32 26 16 7 18 18 0 0.635 1.000 1.000 486 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 21 ALDOA(2), ALDOC(1), FBP1(1), FBP2(4), G6PD(12), GPI(5), H6PD(7), PFKM(2), PFKP(15), PGD(7), PGM1(8), PGM3(5), PRPS1L1(3), PRPS2(6), RBKS(1), RPE(4), RPIA(4), TAL1(2), TALDO1(4), TKT(6) 9337202 99 65 95 40 37 12 12 28 10 0 0.658 1.000 1.000 487 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(20), ESR2(8), ITPKA(3), PDE1A(8), PDE1B(10), PLCB1(22), PLCB2(10), PRL(3), TRH(7), VIP(3) 5653105 94 65 87 34 27 17 13 21 16 0 0.561 1.000 1.000 488 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 8 CD3D(4), CD3E(2), CD4(4), FYN(15), HLA-DRB1(6), LCK(8), PTPRC(27), ZAP70(12) 4220464 78 65 66 26 19 17 12 11 17 2 0.348 1.000 1.000 489 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 15 ATF2(6), IFNG(3), IKBKB(7), IL2(4), IL4(5), JUN(2), MAP3K1(18), MAP3K5(14), MAP4K5(4), MAPK14(7), MAPK8(11), NFKB1(8), NFKBIA(1), RELA(9), TRAF2(8) 8977746 107 64 103 28 31 23 13 25 15 0 0.111 1.000 1.000 490 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(13), KHK(4), LCT(39), MPI(4), PGM1(8), PYGL(6), PYGM(10), TPI1(3), TREH(6) 6970708 93 64 87 29 26 20 15 26 6 0 0.155 1.000 1.000 491 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(8), ACP5(4), ACP6(6), ACPP(3), ACPT(3), ENPP1(17), ENPP3(10), FLAD1(7), LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), PHPT1(2), RFK(1), TYR(9) 7930988 108 64 97 31 30 29 12 20 16 1 0.160 1.000 1.000 492 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(12), POLR1B(13), POLR1C(4), POLR1D(7), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR3A(13), POLR3B(8), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(1) 12162862 101 64 98 28 28 15 22 20 16 0 0.158 1.000 1.000 493 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(12), APAF1(23), BCL2(2), CASP3(3), CASP9(5), CYCS(1), DAXX(14), FAS(7), FASLG(3), HSPB2(2), IL1A(1), MAPKAPK2(4), MAPKAPK3(6), TNF(1) 5583459 84 64 70 36 17 22 11 13 21 0 0.926 1.000 1.000 494 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 10 IL10RA(3), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(20), JAK3(27), STAT1(15), STAT3(10), STAT5A(8), TYK2(5) 7184531 96 64 83 32 28 25 8 19 16 0 0.498 1.000 1.000 495 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 13 CSNK2A1(7), DPM2(1), ELK1(4), FOS(4), HRAS(4), JUN(2), KLK2(4), MAPK3(3), MAPK8(11), NGFR(4), PLCG1(17), SHC1(13), SOS1(11) 6288337 85 64 77 32 22 15 9 18 20 1 0.877 1.000 1.000 496 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 9 AKT1(11), DPM2(1), HRAS(4), KLK2(4), NTRK1(16), PLCG1(17), PRKCA(5), SHC1(13), SOS1(11) 5820663 82 64 70 37 14 15 16 17 19 1 0.963 1.000 1.000 497 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 8 EGF(7), MAP3K1(18), MAPK14(7), NCOR2(38), RARA(5), RXRA(8), THRA(6), THRB(14) 6539226 103 63 92 34 29 16 14 18 26 0 0.641 1.000 1.000 498 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 64 FAU(1), MRPL13(6), MRPS7(4), RPL10A(2), RPL10L(4), RPL11(1), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(2), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(2), RPL7(3), RPL8(3), RPL9(3), RPS10(2), RPS11(2), RPS13(2), RPS16(1), RPS18(1), RPS2(2), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(2), RPS5(2), RPS6(2), RPS7(1), RPS9(3), RPSA(1) 10355172 103 63 99 28 27 23 16 24 13 0 0.220 1.000 1.000 499 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(4), CSF1(4), CSF3(2), HLA-DRB1(6), IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL11(6), IL12A(1), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL7(3), IL8(5), LTA(1), PDGFA(2), TGFB1(2), TGFB2(6), TGFB3(2), TNF(1) 6544903 87 63 79 39 26 16 7 24 11 3 0.895 1.000 1.000 500 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(30), CPT1A(10), LEP(1), LEPR(15), PRKAA1(8), PRKAA2(15), PRKAB1(3), PRKAB2(5), PRKAG1(4), PRKAG2(6) 7781487 97 63 94 28 29 9 11 31 17 0 0.426 1.000 1.000 501 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(18), POLD2(2), POLE(37), POLG(8), POLQ(37) 8638137 106 62 93 33 34 13 17 27 15 0 0.324 1.000 1.000 502 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(2), ATIC(13), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4) 9719681 94 62 88 45 29 14 14 19 16 2 0.951 1.000 1.000 503 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(2), BNIP1(5), GOSR1(4), GOSR2(5), SEC22B(3), SNAP23(2), SNAP25(1), SNAP29(4), STX11(6), STX12(6), STX16(7), STX17(1), STX18(2), STX19(3), STX2(5), STX3(3), STX4(3), STX5(10), STX6(2), STX7(3), STX8(5), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(3), VAMP4(3), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1) 8341316 108 62 96 31 34 11 11 22 30 0 0.435 1.000 1.000 504 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 15 IL18(3), ITGB1(12), KLRC1(2), KLRC2(2), KLRC3(7), KLRC4(3), KLRD1(3), LAT(2), MAPK3(3), PAK1(10), PTK2B(13), PTPN6(4), RAC1(2), SYK(5), VAV1(22) 6966558 93 62 89 36 26 25 7 24 11 0 0.712 1.000 1.000 505 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 14 AKT1(11), BCL2(2), BCR(11), CRKL(5), FOS(4), HRAS(4), JUN(2), MAP3K1(18), MAPK3(3), MAPK8(11), MYC(5), SOS1(11), STAT1(15), STAT5A(8) 8180474 110 61 107 34 34 20 15 24 17 0 0.199 1.000 1.000 506 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 10 AKT1(11), CAT(7), GH1(4), GHR(12), HRAS(4), IGF1(6), IGF1R(17), SHC1(13), SOD2(4) 4732422 78 61 68 27 26 9 11 17 14 1 0.464 1.000 1.000 507 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(11), PLCB1(22), PLCG1(17), PRKCA(5), VAV1(22) 4847551 77 61 71 33 25 21 11 14 6 0 0.793 1.000 1.000 508 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(20), CLTA(5), CLTB(2), COPA(13), GBF1(17), GPLD1(12), KDELR1(5), KDELR3(2) 8292486 88 60 87 34 25 15 10 19 19 0 0.825 1.000 1.000 509 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(15), PSMD11(8), PSMD12(4), PSMD13(6), PSMD2(3), PSMD6(5) 8627918 81 59 76 36 20 21 11 18 11 0 0.897 1.000 1.000 510 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(2), ATIC(13), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(8), MTHFD1L(11), MTHFD2(2), MTHFR(8), MTHFS(1), MTR(13), SHMT1(6), SHMT2(5), TYMS(4) 9430955 89 59 82 43 26 15 13 18 15 2 0.949 1.000 1.000 511 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(7), CD28(4), CD3D(4), CD3E(2), CD4(4), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27) 5619971 86 59 81 35 22 14 13 18 19 0 0.787 1.000 1.000 512 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(10), FOS(4), JUN(2), MAPK3(3), OPRK1(12), POLR2A(12), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4) 6640353 71 58 68 19 26 13 5 12 15 0 0.155 1.000 1.000 513 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 14 ADRB2(3), AKT1(11), ANXA1(3), CALM2(1), CALM3(1), GNB1(3), NFKB1(8), NOS3(21), NPPA(1), NR3C1(8), RELA(9), SYT1(14) 5864750 83 58 69 30 22 24 9 13 15 0 0.582 1.000 1.000 514 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(3), DHRS1(4), DHRS2(5), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2) 7099195 77 58 77 30 15 19 8 24 11 0 0.782 1.000 1.000 515 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), DCXR(1), GUSB(4), RPE(4), UCHL1(1), UCHL3(1), UGDH(8), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(6), UGT1A5(5), UGT1A6(7), UGT1A7(8), UGT1A8(6), UGT1A9(9), UGT2B15(3), UGT2B4(9) 8920638 89 58 75 27 25 13 11 12 28 0 0.538 1.000 1.000 516 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 21 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), FDXR(5), SHMT1(6) 7873082 88 58 79 38 28 23 11 15 11 0 0.800 1.000 1.000 517 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(7), IFNB1(6), JAK1(20), PTPRU(18), REG1A(6), STAT1(15), STAT2(10), TYK2(5) 6410913 87 58 81 21 30 20 8 16 13 0 0.0846 1.000 1.000 518 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 14 CD28(4), CD3D(4), CD3E(2), IFNG(3), IL2(4), IL2RA(3), IL4(5), TGFB1(2), TGFB2(6), TGFB3(2), TGFBR1(17), TGFBR2(24), TGFBR3(14), TOB2(2) 5076433 92 58 80 36 33 20 10 16 13 0 0.641 1.000 1.000 519 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(6), CYB5R3(1), GCK(3), GFPT1(5), GNE(7), GNPDA1(2), GNPDA2(3), HEXA(3), HEXB(3), HK1(13), HK2(6), HK3(17), PGM3(5), RENBP(3), UAP1(6) 8750177 83 57 80 29 26 21 8 17 11 0 0.525 1.000 1.000 520 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6) 7519622 83 57 74 37 27 22 11 13 10 0 0.833 1.000 1.000 521 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6) 7519622 83 57 74 37 27 22 11 13 10 0 0.833 1.000 1.000 522 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(4), GALNT10(8), GALNT2(10), GALNT3(15), GALNT6(10), GALNT7(5), GALNT8(4), GALNT9(9), GCNT1(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4) 6850435 79 57 77 37 29 15 12 9 14 0 0.881 1.000 1.000 523 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(7), CD28(4), CD3D(4), CD3E(2), CD8A(1), ICAM1(4), ITGAL(18), ITGB2(16), PTPRC(27) 5275922 83 57 78 33 23 14 11 17 18 0 0.740 1.000 1.000 524 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(4), CD86(2), HLA-DRB1(6), IFNG(3), IFNGR1(6), IFNGR2(4), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), IL18(3), IL18R1(13), IL2(4), IL2RA(3), IL4(5), IL4R(6) 6326465 81 57 74 30 18 15 10 22 13 3 0.626 1.000 1.000 525 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP5O(4), ATP6AP1(5), ATP6V0A1(5), ATP6V0A4(14), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(11), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(3), ATP6V1G3(2), ATP6V1H(5), SHMT1(6) 7519622 83 57 74 37 27 22 11 13 10 0 0.833 1.000 1.000 526 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 14 B3GAT1(6), B3GAT2(1), B3GAT3(1), B4GALT7(2), CHPF(10), CHST11(4), CHST12(4), CHST14(1), CHST3(6), CHSY1(14), DSE(9), UST(10), XYLT1(12) 5802932 80 56 72 40 34 13 12 13 7 1 0.863 1.000 1.000 527 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(7), IFNB1(6), IFNG(3), IL10(1), IL12A(1), IL12B(1), IL13(2), IL15(1), IL16(14), IL18(3), IL1A(1), IL2(4), IL3(6), IL4(5), IL6(5), IL8(5), IL9(1), LTA(1), TNF(1) 5013721 68 55 61 36 20 15 6 20 7 0 0.931 1.000 1.000 528 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 15 ALOX12(3), ALOX15(4), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(2), LTA4H(2), PLA2G6(8), PTGDS(2), PTGES(1), PTGIS(6), PTGS1(9), PTGS2(9), TBXAS1(11) 7036192 81 55 80 35 28 11 11 21 10 0 0.759 1.000 1.000 529 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(10), CYP2A13(11), CYP2A6(10), CYP2A7(14), NAT1(1), NAT2(3), XDH(19) 4269526 68 55 64 30 22 13 9 18 6 0 0.832 1.000 1.000 530 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 15 AKT1(11), BAD(1), BCL2L1(1), CASP9(5), CDC42(2), ELK1(4), H2AFX(1), HRAS(4), MAPK3(3), NFKB1(8), RAC1(2), RALA(7), RALBP1(6), RALGDS(7), RELA(9) 5557083 71 55 67 25 29 11 12 9 10 0 0.337 1.000 1.000 531 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK1(20), JAK3(27), MAPK1(3), MAPK3(3), STAT3(10), TYK2(5) 4652839 68 55 56 21 21 20 6 11 10 0 0.423 1.000 1.000 532 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 13 CUZD1(8), FOS(4), HRAS(4), JUN(2), MAPK1(3), MAPK3(3), MYC(5), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RELA(9), TNF(1) 6656461 75 54 71 35 18 14 13 16 14 0 0.905 1.000 1.000 533 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 10 ADCY1(22), ADRB2(3), CFTR(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), SLC9A3R1(3) 5617093 69 54 66 25 21 17 3 18 10 0 0.453 1.000 1.000 534 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(5), FDFT1(3), FDPS(6), GGCX(8), GGPS1(4), HMGCR(6), IDI1(4), IDI2(3), LSS(4), MVD(3), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1), TM7SF2(2) 9328085 80 54 78 31 23 8 12 23 14 0 0.812 1.000 1.000 535 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(12), CD38(4), ENPP1(17), ENPP3(10), NADSYN1(4), NMNAT1(2), NMNAT2(4), NNMT(4), NNT(5), NT5C(1), NT5E(6), NT5M(3), QPRT(2) 7785195 74 54 68 23 21 18 9 17 8 1 0.146 1.000 1.000 536 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(10), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(2), CDK5R1(5), CSNK1A1(3), CSNK1D(14), GSK3B(16), MAPT(10), PPP2CA(3) 4347482 73 54 70 23 25 17 5 16 10 0 0.357 1.000 1.000 537 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), EPO(1), FLT3(27), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(5), IL9(1), KITLG(3), TGFB1(2), TGFB2(6), TGFB3(2) 4375309 68 53 62 34 18 17 4 18 10 1 0.964 1.000 1.000 538 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(6), IL10(1), IL10RA(3), IL10RB(6), IL1A(1), IL6(5), JAK1(20), STAT1(15), STAT3(10), STAT5A(8), TNF(1) 6253500 79 53 70 31 25 14 6 19 15 0 0.755 1.000 1.000 539 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(13), ADSS(5), DHFR(1), HPRT1(2), IMPDH1(3), MTHFD2(2), POLB(4), POLD1(18), POLG(8), PRPS2(6), RRM1(2), SRM(1) 6276418 65 53 63 26 24 6 10 12 13 0 0.729 1.000 1.000 540 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(4), FOSL1(1), FOSL2(4), IFNAR1(7), IFNAR2(3), IFNB1(6), MAPK8(11), NFKB1(8), RELA(9), TNFRSF11A(5), TNFSF11(8), TRAF6(4) 5597305 70 53 68 24 19 15 9 12 15 0 0.410 1.000 1.000 541 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(16), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(2), CDK2(5), CDK4(3), CDKN1B(4), CDKN2A(7), E2F2(7), E2F4(2), PRB1(3) 4415905 61 53 57 23 13 12 9 18 9 0 0.595 1.000 1.000 542 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(16), CKM(6), FBL(6), GPT(6), LDHA(10), LDHB(5), LDHC(4), MAPK14(7), NCL(10) 4545633 70 53 63 27 17 16 10 20 7 0 0.634 1.000 1.000 543 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(10), GNB1(3), HTR2C(13), PLCB1(22), TUB(13) 3723592 65 53 64 26 26 12 7 15 5 0 0.654 1.000 1.000 544 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 13 CALM2(1), CALM3(1), CAMK1G(5), CAMK2A(4), CAMK2B(4), CAMK2D(7), CAMK2G(11), CAMK4(6), CAMKK1(2), CAMKK2(8), CREB1(3), SYT1(14) 5507579 66 52 60 33 15 18 7 13 13 0 0.946 1.000 1.000 545 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(6), PRMT3(6), PRMT5(7), PRMT6(2), PRMT7(6), PRMT8(9), WBSCR22(2) 7032103 68 51 70 32 14 16 7 20 11 0 0.966 1.000 1.000 546 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 13 CCR5(11), CD2(7), CD3D(4), CD3E(2), CD4(4), CXCR3(4), IFNG(3), IL12A(1), IL12B(1), IL12RB1(5), IL12RB2(15), STAT4(10), TYK2(5) 6280228 72 51 66 28 10 16 14 22 10 0 0.716 1.000 1.000 547 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 9 CSF2RB(13), FOS(4), HRAS(4), IL3(6), MAPK3(3), PTPN6(4), SHC1(13), SOS1(11), STAT5A(8) 5202160 66 50 57 23 20 11 4 11 19 1 0.796 1.000 1.000 548 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(6), UBE2A(4), UBE3A(19) 6949809 72 50 69 29 18 16 10 16 12 0 0.740 1.000 1.000 549 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 7 CD3D(4), CD3E(2), GZMB(4), ICAM1(4), ITGAL(18), ITGB2(16), PRF1(7) 3616766 55 49 52 24 26 8 3 6 12 0 0.763 1.000 1.000 550 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 11 AHCY(7), CBS(3), CTH(5), MARS(12), MARS2(5), MAT1A(8), MAT2B(5), PAPSS1(4), PAPSS2(5), SCLY(11), SEPHS1(5) 5874445 70 49 65 20 24 8 11 15 12 0 0.145 1.000 1.000 551 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(5), MAX(5), MYC(5), SP1(6), SP3(10), WT1(28) 3132555 59 49 52 28 11 19 14 9 6 0 0.800 1.000 1.000 552 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(6), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10) 4818345 67 48 66 22 19 9 7 22 10 0 0.494 1.000 1.000 553 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(5), FARSA(6), FARSB(11), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4), YARS2(6) 4613164 69 48 63 21 18 8 10 22 11 0 0.393 1.000 1.000 554 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), IMPA2(3), ISYNA1(6), PGM1(8), PGM3(5) 5688831 65 48 62 31 23 11 7 16 8 0 0.858 1.000 1.000 555 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(6), B3GALNT1(5), B3GALT5(3), FUT1(8), FUT2(6), FUT9(9), GBGT1(1), GLA(7), HEXA(3), HEXB(3), NAGA(7), ST3GAL1(2), ST3GAL2(1), ST8SIA1(10) 5160355 71 48 69 23 23 8 8 22 10 0 0.435 1.000 1.000 556 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 ECHS1(3), EHHADH(13), HADH(2), HADHA(10), HSD17B10(2), HSD17B4(9), SIRT1(7), SIRT2(2), SIRT5(2), SIRT7(3), VNN2(4) 5826348 57 48 55 19 20 9 9 10 9 0 0.371 1.000 1.000 557 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 12 CYSLTR1(9), GPR109B(5), GPR161(10), GPR171(10), GPR18(3), GPR34(10), GPR39(3), GPR45(11), GPR65(1), GPR68(5), GPR75(9) 4747692 76 47 67 35 20 14 6 20 15 1 0.959 1.000 1.000 558 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(7), B4GALT2(7), B4GALT3(6), B4GALT5(4), FUT8(10), ST3GAL1(2), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 3915509 58 47 53 17 23 13 3 11 8 0 0.429 1.000 1.000 559 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(10), NFKB1(8), NFKBIA(1), PLCB1(22), PRKCA(5), RELA(9) 4316122 55 47 52 21 15 12 7 13 8 0 0.662 1.000 1.000 560 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(10), NEK1(20) 3202331 57 47 52 19 10 11 3 16 16 1 0.845 1.000 1.000 561 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(12), CD44(5), CSF1(4), FCGR3A(4), IL1B(4), IL6R(7), SELL(5), SPN(4), TGFB1(2), TGFB2(6), TNF(1), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(7), TNFSF8(4) 6662233 70 47 69 21 22 8 12 16 12 0 0.211 1.000 1.000 562 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(16), CHKA(4), PCYT1A(4), PDHA1(7), PDHA2(14), PEMT(2), SLC18A3(11) 3473981 61 45 60 36 26 9 10 11 5 0 0.942 1.000 1.000 563 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 11 AKT1(11), BAD(1), CASP9(5), GH1(4), GHR(12), NFKB1(8), NFKBIA(1), PDPK1(4), PPP2CA(3), RELA(9), YWHAH(3) 4621331 61 45 56 24 20 11 10 14 6 0 0.622 1.000 1.000 564 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(3), HBXIP(4), HRAS(4), PTK2B(13), SHC1(13), SOS1(11), SRC(3) 4250933 51 45 45 16 7 7 8 12 16 1 0.735 1.000 1.000 565 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(5), B3GALT1(3), B3GALT2(10), B3GALT5(3), B3GNT5(3), FUT1(8), FUT2(6), FUT3(4), ST3GAL3(12), ST3GAL4(4) 3540206 58 45 55 22 26 6 3 14 9 0 0.706 1.000 1.000 566 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(25), GNA12(6), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(3), PRKAR2B(4) 5350557 54 44 52 15 13 8 7 15 11 0 0.354 1.000 1.000 567 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR1B(13), POLR2A(12), POLR2B(11), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLRMT(13) 6380793 63 44 61 19 22 12 7 12 10 0 0.430 1.000 1.000 568 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(15), EGF(7), HGS(10), RAB5A(3), TF(16), TFRC(5) 5294259 56 43 48 18 11 15 6 10 13 1 0.338 1.000 1.000 569 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 ARNT(8), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(14), NFKB1(8), NFKBIA(1), RELA(9), SOD2(4) 5265739 54 43 52 16 13 9 9 11 12 0 0.350 1.000 1.000 570 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 7 CAMK1G(5), HDAC9(18), MEF2A(5), MEF2C(15), MEF2D(3), YWHAH(3) 3326913 49 42 56 26 16 7 2 16 7 1 0.968 1.000 1.000 571 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(2), ENO3(5), FARS2(5), GOT1(6), GOT2(2), PAH(15), TAT(14), YARS(4) 4455212 56 42 51 24 13 7 12 17 7 0 0.840 1.000 1.000 572 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 8 CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(5), CSK(3), PRKCA(5), PTPRA(5), SRC(3) 4553477 51 42 51 22 13 12 5 16 5 0 0.766 1.000 1.000 573 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3) 3882671 52 41 52 23 26 6 6 7 7 0 0.746 1.000 1.000 574 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 8 ENO1(3), GPI(5), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(11), TPI1(3) 3979895 49 41 46 23 19 7 4 13 6 0 0.874 1.000 1.000 575 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 9 AKR1D1(8), CYP11A1(5), CYP11B1(13), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3) 3882671 52 41 52 23 26 6 6 7 7 0 0.746 1.000 1.000 576 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(13), HK2(6), HK3(17), IMPA1(4), PGM1(8), PGM3(5) 5185687 56 41 53 27 19 10 6 15 6 0 0.879 1.000 1.000 577 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(9), LARS(12), LARS2(5), PDHA1(7), PDHA2(14), PDHB(3) 5306104 55 41 55 23 17 11 9 10 8 0 0.786 1.000 1.000 578 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(5), MTMR1(12), MTMR2(7), MTMR6(9), NFS1(5), PHPT1(2), THTPA(2), TPK1(5) 3347996 47 40 43 14 14 12 5 8 8 0 0.393 1.000 1.000 579 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(12), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(5), APOBEC3F(1), APOBEC3G(6), APOBEC4(7) 3914814 48 38 47 15 19 4 9 8 8 0 0.365 1.000 1.000 580 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 11 CD2(7), CD34(7), CD3D(4), CD3E(2), CD4(4), CD8A(1), CSF3(2), IL3(6), IL6(5), IL8(5), KITLG(3) 2910538 46 38 40 21 8 13 5 12 8 0 0.776 1.000 1.000 581 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(9), MBTPS1(11), MBTPS2(2), SCAP(6), SREBF1(8), SREBF2(9) 5502059 46 38 45 25 13 10 8 8 7 0 0.884 1.000 1.000 582 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(3), FOS(4), FYN(15), JUN(2), MAPK14(7), THBS1(12) 3778936 46 37 42 17 12 7 6 8 13 0 0.533 1.000 1.000 583 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 10 ARRB1(4), GNB1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(3), PRKAR2A(3), PRKAR2B(4), PRKCA(5) 3990321 37 36 37 25 10 11 1 7 8 0 0.985 1.000 1.000 584 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(12), AOC3(9), CES1(13), ESD(4) 2998414 42 36 41 17 15 6 6 10 5 0 0.624 1.000 1.000 585 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 13 DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), IDI1(4), LSS(4), MVD(3), NQO1(1), NQO2(2), PMVK(2), SC5DL(7), SQLE(1) 5018238 43 36 41 15 13 7 6 13 4 0 0.498 1.000 1.000 586 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 13 BPNT1(9), CHST11(4), CHST12(4), PAPSS1(4), PAPSS2(5), SULT1A1(4), SULT1A2(4), SULT1E1(5), SULT2A1(4), SULT2B1(4), SUOX(5) 4883015 52 36 49 18 17 8 5 14 8 0 0.565 1.000 1.000 587 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(3), FOS(4), JUN(2), KEAP1(5), MAPK1(3), MAPK14(7), MAPK8(11), NFE2L2(4), PRKCA(5) 4239099 44 35 44 21 8 9 4 16 7 0 0.925 1.000 1.000 588 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 14 CYP51A1(3), DHCR7(4), FDFT1(3), FDPS(6), HMGCR(6), HMGCS1(1), IDI1(4), LSS(4), MVD(3), NSDHL(2), PMVK(2), SC4MOL(2), SC5DL(7), SQLE(1) 6186199 48 34 47 18 14 7 6 15 6 0 0.691 1.000 1.000 589 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(9), NR1H3(16), NR1H4(7), RXRA(8) 2597155 42 34 35 20 11 8 6 6 11 0 0.939 1.000 1.000 590 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(8), F13B(10), HSD17B1(2), HSD17B2(6), HSD17B3(4), HSD17B4(9), HSD3B1(5), HSD3B2(3) 4242355 47 34 45 19 16 10 7 9 5 0 0.524 1.000 1.000 591 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(5), FUT1(8), FUT2(6), FUT3(4), FUT5(3), FUT6(1), ST3GAL3(12) 2030097 39 32 37 18 21 5 2 8 3 0 0.756 1.000 1.000 592 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 10 CDK5(2), CDK5R1(5), DPM2(1), EGR1(11), HRAS(4), KLK2(4), MAP2K2(2), MAPK1(3), MAPK3(3), NGFR(4) 2675811 39 32 37 17 14 3 3 10 9 0 0.751 1.000 1.000 593 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(6), PLCG1(17), PRKCA(5), PTK2B(13) 3447846 41 32 39 23 11 11 5 8 6 0 0.974 1.000 1.000 594 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(10), CYP2E1(9), NR1I3(3), PTGS1(9), PTGS2(9) 2793524 40 31 40 15 18 4 8 7 3 0 0.605 1.000 1.000 595 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(8), CYP11A1(5), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(5), HSD3B2(3) 3506464 39 31 38 23 17 6 6 5 5 0 0.913 1.000 1.000 596 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(11), ALAS2(10), CPOX(3), FECH(3), HMBS(4), PPOX(5), UROD(2), UROS(5) 4051107 43 31 39 11 17 7 5 8 6 0 0.360 1.000 1.000 597 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(6), GOT2(2), TAT(14), TYR(9) 2521444 36 31 30 18 10 5 9 10 2 0 0.865 1.000 1.000 598 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(8), GAD1(15), HDC(8), PNMT(3), TPH1(2) 2671897 36 30 34 17 11 6 2 13 4 0 0.862 1.000 1.000 599 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(6), PSMA3(3), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(2), PSMB8(6), PSMB9(4) 4401070 37 30 36 19 9 5 5 10 8 0 0.929 1.000 1.000 600 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(9), ACADS(3), ACAT1(7), ECHS1(3), HADHA(10) 2793555 36 29 36 15 9 6 5 7 9 0 0.713 1.000 1.000 601 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(9), ALPP(8), ALPPL2(1), DHFR(1), FPGS(4), GGH(1), SPR(7) 2772845 35 29 34 14 11 7 5 8 4 0 0.598 1.000 1.000 602 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(7), ACAT2(8), BDH1(3), BDH2(2), HMGCS1(1), HMGCS2(5), OXCT1(3), OXCT2(3) 3844184 32 29 30 11 10 6 3 6 7 0 0.590 1.000 1.000 603 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(7), CSF1(4), IL6(5), LDLR(9), LPL(12) 2735901 37 29 35 18 10 11 3 7 6 0 0.796 1.000 1.000 604 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(12), NR3C1(8), PPARG(4), RETN(2), RXRA(8), TNF(1) 2821698 37 29 35 23 10 5 8 8 6 0 0.972 1.000 1.000 605 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12) 2342704 29 28 27 20 14 7 2 3 2 1 0.980 1.000 1.000 606 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(1), B4GALT7(2), HS3ST1(3), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(4), XYLT1(12) 2342704 29 28 27 20 14 7 2 3 2 1 0.980 1.000 1.000 607 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 5 ADCY1(22), GNB1(3), PRKACA(1), PRKAR1A(3) 2218568 29 27 26 16 14 9 2 3 1 0 0.815 1.000 1.000 608 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(9), PRKCA(5), TGM2(15) 2559717 34 27 33 19 13 6 3 9 3 0 0.904 1.000 1.000 609 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 8 ASAH1(4), CAMP(1), CREB1(3), CREB3(5), CREB5(5), MAPK1(3), SRC(3), TERF2IP(3) 3115633 27 23 27 13 3 5 4 8 7 0 0.865 1.000 1.000 610 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(7), ARG1(2), GLS(2), GLUD1(4), OAT(3), PRODH(5) 2793487 23 22 22 10 10 6 2 1 4 0 0.668 1.000 1.000 611 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(1), CCR3(9), HLA-DRB1(6), IL3(6) 1199864 22 21 18 10 4 8 0 7 1 2 0.922 1.000 1.000 612 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(4), CD4(4), CD80(4), HLA-DRB1(6), IL10(1), IL2(4), IL4(5) 1778678 28 20 27 11 7 3 4 8 4 2 0.770 1.000 1.000 613 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(2), TAT(14) 1417414 22 20 17 11 7 1 7 5 2 0 0.839 1.000 1.000 614 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(9), SNAP25(1), STX1A(3), VAMP2(1) 1689745 18 18 16 10 7 4 3 3 1 0 0.943 1.000 1.000 615 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(6), IFNG(3), IL12A(1), IL12B(1), IL18(3), IL2(4) 1606799 18 14 17 14 1 4 5 6 2 0 0.989 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 273768 1 1 1 2 1 0 0 0 0 0 0.955 1.000 1.000