Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.024 0.026 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.011 0.021 -9999.0 0.0 -0.436 1.0 1.0 ENAH 0.051 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.011 0.021 -9999.0 0.0 -0.436 1.0 1.0 EPHA2 0.011 0.035 -9999.0 0.0 -0.731 1.0 1.0 MYO6 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.025 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.023 0.114 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.021 0.046 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.089 0.207 -9999.0 0.0 -0.491 91.0 91.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.029 0.061 -9999.0 0.0 -0.392 1.0 1.0 cortical microtubule organization 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.011 0.021 -9999.0 0.0 -0.436 1.0 1.0 ARF6/GDP -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.03 0.024 -9999.0 0.0 -0.429 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.039 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.033 0.023 -9999.0 0.0 -0.395 1.0 1.0 CDH1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.043 0.091 -9999.0 0.0 -0.369 17.0 17.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.011 0.021 -9999.0 0.0 -0.436 1.0 1.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.1 0.194 -9999.0 0.0 -0.436 114.0 114.0 DIAPH1 -0.001 0.025 -9999.0 0.0 -0.536 1.0 1.0 Wnt receptor signaling pathway -0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.001 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.001 0.017 -9999.0 0.0 -0.369 1.0 1.0 SEC6/SEC8 -0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.021 0.047 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.008 0.048 -9999.0 0.0 -0.369 6.0 6.0 HGF 0.003 0.068 -9999.0 0.0 -0.469 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.024 0.026 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.065 0.015 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.016 0.079 -9999.0 0.0 -0.387 17.0 17.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.018 0.015 -9999.0 0.0 -0.301 1.0 1.0 mol:GDP 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.006 0.051 -9999.0 0.0 -0.436 6.0 6.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.049 0.02 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.038 0.059 -9999.0 0.0 -0.539 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.044 0.076 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.018 0.015 -9999.0 0.0 -0.301 1.0 1.0 MET 0.004 0.077 -9999.0 0.0 -0.731 5.0 5.0 PLEKHA7 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.029 0.024 -9999.0 0.0 -0.426 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.049 0.009 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.024 0.026 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.024 0.026 -9999.0 0.0 -9999.0 0.0 0.0