E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.022 0.035 -9999.0 0.0 -0.306 3.0 3.0 KLHL20 0.042 0.075 0.206 28.0 -0.232 7.0 35.0 CYFIP2 0.026 0.02 -9999.0 0.0 -0.395 1.0 1.0 Rac1/GDP 0.068 0.08 0.226 14.0 -9999.0 0.0 14.0 ENAH 0.022 0.035 -9999.0 0.0 -0.306 3.0 3.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.008 0.028 -9999.0 0.0 -0.159 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.056 -9999.0 0.0 -0.214 7.0 7.0 RAPGEF1 0.056 0.082 0.307 6.0 -9999.0 0.0 6.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.03 0.037 -9999.0 0.0 -0.312 3.0 3.0 CRK 0.056 0.076 -9999.0 0.0 -0.299 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.018 -9999.0 0.0 -0.236 1.0 1.0 alphaE/beta7 Integrin 0.022 0.061 -9999.0 0.0 -0.266 18.0 18.0 IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.022 0.036 -9999.0 0.0 -0.306 3.0 3.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.005 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.019 0.086 -9999.0 0.0 -0.231 44.0 44.0 PI3K 0.009 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.039 0.016 -9999.0 0.0 -0.279 1.0 1.0 TIAM1 -0.012 0.122 -9999.0 0.0 -0.395 41.0 41.0 E-cadherin(dimer)/Ca2+ 0.062 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.032 0.041 0.104 25.0 -9999.0 0.0 25.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.081 0.081 0.28 7.0 -9999.0 0.0 7.0 actin cytoskeleton organization 0.04 0.062 0.174 31.0 -0.168 7.0 38.0 CDC42/GDP 0.075 0.08 0.274 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.02 0.012 -9999.0 0.0 -0.204 1.0 1.0 ITGB7 0.01 0.083 -9999.0 0.0 -0.395 18.0 18.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.067 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.072 0.088 0.276 8.0 -0.287 1.0 9.0 CDC42/GTP/IQGAP1 0.033 0.017 -9999.0 0.0 -0.233 1.0 1.0 JUP 0.026 0.02 -9999.0 0.0 -0.395 1.0 1.0 p120 catenin/RhoA/GDP 0.089 0.081 0.29 6.0 -9999.0 0.0 6.0 RAC1/GTP/IQGAP1 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.016 -9999.0 0.0 -0.279 1.0 1.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.021 -9999.0 0.0 -0.395 1.0 1.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.032 0.047 0.136 32.0 -0.165 3.0 35.0 NME1 0.019 0.066 0.36 1.0 -0.426 9.0 10.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.021 0.035 -9999.0 0.0 -0.306 3.0 3.0 regulation of cell-cell adhesion 0.012 0.016 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.08 0.071 0.293 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.058 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.036 0.054 0.152 31.0 -0.202 3.0 34.0 VAV2 0.071 0.137 -9999.0 0.0 -0.629 10.0 10.0 RAP1/GDP 0.088 0.078 0.289 7.0 -9999.0 0.0 7.0 adherens junction assembly 0.02 0.035 -9999.0 0.0 -0.298 3.0 3.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.02 -9999.0 0.0 -0.395 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.044 0.052 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.013 0.011 -9999.0 0.0 -0.153 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.014 0.03 -9999.0 0.0 -0.308 2.0 2.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.066 -9999.0 0.0 -0.365 8.0 8.0 E-cadherin/beta catenin/alpha catenin 0.054 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.037 -9999.0 0.0 -0.318 3.0 3.0