Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.028 0.061 0.3 14.0 -0.236 1.0 15.0 KIRREL 0.022 0.047 -9999.0 0.0 -0.407 5.0 5.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.028 0.061 0.237 1.0 -0.301 14.0 15.0 PLCG1 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.044 0.075 0.23 1.0 -0.233 27.0 28.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.032 0.161 1.0 -0.207 5.0 6.0 FYN 0.012 0.061 0.272 11.0 -0.234 5.0 16.0 mol:Ca2+ 0.028 0.056 -9999.0 0.0 -0.229 13.0 13.0 mol:DAG 0.029 0.056 -9999.0 0.0 -0.23 13.0 13.0 NPHS2 0.013 0.045 -9999.0 0.0 -0.422 4.0 4.0 mol:IP3 0.029 0.056 -9999.0 0.0 -0.23 13.0 13.0 regulation of endocytosis 0.036 0.049 0.21 1.0 -0.333 1.0 2.0 Nephrin/NEPH1/podocin/Cholesterol 0.036 0.054 0.211 1.0 -0.226 16.0 17.0 establishment of cell polarity 0.028 0.061 0.236 1.0 -0.3 14.0 15.0 Nephrin/NEPH1/podocin/NCK1-2 0.065 0.058 -9999.0 0.0 -0.38 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.038 0.051 0.218 1.0 -0.337 1.0 2.0 NPHS1 0.015 0.067 0.327 1.0 -0.428 9.0 10.0 Nephrin/NEPH1/podocin 0.038 0.049 0.214 1.0 -0.2 16.0 17.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.057 -9999.0 0.0 -0.231 13.0 13.0 CD2AP 0.016 0.068 -9999.0 0.0 -0.395 12.0 12.0 Nephrin/NEPH1/podocin/GRB2 0.051 0.059 -9999.0 0.0 -0.234 12.0 12.0 GRB2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.012 0.078 0.281 9.0 -0.235 23.0 32.0 cytoskeleton organization 0.01 0.042 0.205 4.0 -0.279 1.0 5.0 Nephrin/NEPH1 0.025 0.043 0.194 1.0 -0.205 14.0 15.0 Nephrin/NEPH1/ZO-1 0.04 0.053 0.225 1.0 -0.233 14.0 15.0