Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.013 0.099 -9999.0 0.0 -0.472 10.0 10.0 IHH 0.019 0.085 -9999.0 0.0 -0.448 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.049 0.129 0.187 2.0 -0.251 120.0 122.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.048 0.128 0.25 120.0 -0.185 2.0 122.0 SMO/beta Arrestin2 0.018 0.09 -9999.0 0.0 -0.484 5.0 5.0 SMO 0.006 0.085 -9999.0 0.0 -0.506 5.0 5.0 AKT1 0.0 0.109 -9999.0 0.0 -0.398 14.0 14.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.059 -9999.0 0.0 -0.395 9.0 9.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.007 0.085 -9999.0 0.0 -0.498 5.0 5.0 STIL -0.017 0.107 -9999.0 0.0 -0.345 9.0 9.0 DHH N/PTCH2 0.024 0.066 -9999.0 0.0 -0.28 20.0 20.0 DHH N/PTCH1 0.021 0.091 -9999.0 0.0 -0.409 8.0 8.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.006 0.085 -9999.0 0.0 -0.395 19.0 19.0 PTHLH 0.007 0.128 -9999.0 0.0 -0.744 9.0 9.0 determination of left/right symmetry 0.007 0.085 -9999.0 0.0 -0.498 5.0 5.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.008 0.127 -9999.0 0.0 -0.736 9.0 9.0 IHH N/Hhip -0.039 0.152 -9999.0 0.0 -0.318 100.0 100.0 DHH N/Hhip -0.039 0.147 -9999.0 0.0 -0.304 101.0 101.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.007 0.085 -9999.0 0.0 -0.498 5.0 5.0 pancreas development -0.062 0.17 -9999.0 0.0 -0.395 93.0 93.0 HHAT 0.023 0.04 -9999.0 0.0 -0.395 4.0 4.0 PI3K 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.033 0.148 -9999.0 0.0 -0.398 63.0 63.0 somite specification 0.007 0.085 -9999.0 0.0 -0.498 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.018 0.106 -9999.0 0.0 -0.359 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.02 0.101 0.187 4.0 -0.229 82.0 86.0 SHH Np/Cholesterol/Megalin -0.042 0.123 0.18 4.0 -0.249 110.0 114.0 SHH -0.041 0.124 0.273 4.0 -0.302 80.0 84.0 catabolic process 0.018 0.077 -9999.0 0.0 -0.401 8.0 8.0 SMO/Vitamin D3 -0.014 0.108 -9999.0 0.0 -0.391 9.0 9.0 SHH Np/Cholesterol/Hhip -0.063 0.128 0.185 4.0 -0.234 155.0 159.0 LRP2 -0.033 0.125 -9999.0 0.0 -0.426 40.0 40.0 receptor-mediated endocytosis -0.028 0.11 -9999.0 0.0 -0.404 11.0 11.0 SHH Np/Cholesterol/BOC -0.023 0.103 0.187 3.0 -0.231 86.0 89.0 SHH Np/Cholesterol/CDO -0.019 0.1 0.187 3.0 -0.23 81.0 84.0 mesenchymal cell differentiation 0.063 0.127 0.232 155.0 -0.183 4.0 159.0 mol:Vitamin D3 -0.012 0.115 -9999.0 0.0 -0.36 9.0 9.0 IHH N/PTCH2 0.031 0.058 -9999.0 0.0 -0.269 14.0 14.0 CDON 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.026 0.08 -9999.0 0.0 -0.404 8.0 8.0 Megalin/LRPAP1 0.005 0.097 -9999.0 0.0 -0.303 40.0 40.0 PTCH2 0.025 0.022 -9999.0 0.0 -0.426 1.0 1.0 SHH Np/Cholesterol -0.029 0.094 -9999.0 0.0 -0.228 81.0 81.0 PTCH1 0.018 0.078 -9999.0 0.0 -0.402 8.0 8.0 HHIP -0.062 0.171 -9999.0 0.0 -0.395 93.0 93.0