rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(11) 513817 11 11 11 1 9 0 1 1 0 0 0.107 0.152 1.000 2 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(9), LIPT1(13) 1090040 22 19 17 1 0 3 2 6 11 0 0.132 0.217 1.000 3 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOA(2), ALDOB(16), ALDOC(3), TPI1(3) 2558746 30 28 26 3 6 6 2 15 1 0 0.0266 0.677 1.000 4 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(3) 1063963 9 9 9 1 0 1 1 7 0 0 0.306 0.788 1.000 5 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(5), CD4(4), HLA-DRB1(7) 1196858 16 14 15 7 2 0 2 5 5 2 0.941 0.871 1.000 6 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPX1(5), PRKCE(6) 5195954 119 86 107 26 31 17 14 40 17 0 0.00673 0.898 1.000 7 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(12), ALDH1A2(17), BCMO1(5), RDH5(2) 2727712 36 33 35 8 10 8 5 9 4 0 0.117 0.956 1.000 8 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), GSTZ1(5), HGD(6) 1586183 15 13 14 4 1 3 5 4 2 0 0.278 0.962 1.000 9 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 2 CD3D(5), CD3E(2) 572147 7 7 4 3 0 5 1 0 1 0 0.673 0.970 1.000 10 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(3), CDO1(3), CSAD(6), GAD1(17), GAD2(15), GGT1(11) 3850754 55 48 40 11 18 6 7 11 13 0 0.0786 0.978 1.000 11 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4) 5488463 93 66 81 13 29 20 13 21 10 0 0.000189 0.979 1.000 12 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4) 5488463 93 66 81 13 29 20 13 21 10 0 0.000189 0.979 1.000 13 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(4), CASP8(20), CFL1(2), CFLAR(3), PDE6D(2) 2623925 33 30 31 5 5 3 4 8 13 0 0.130 0.980 1.000 14 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), IL8(6), SLPI(2) 1095078 17 16 16 7 2 3 2 4 6 0 0.766 0.985 1.000 15 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GBA3(3), GGT1(11), SHMT1(7), SHMT2(5) 2503588 27 27 23 8 6 1 3 3 14 0 0.734 0.992 1.000 16 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(5), HLCS(14), SPCS1(3), SPCS3(2) 2144483 24 21 22 6 9 3 2 7 3 0 0.201 0.997 1.000 17 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), SDS(3) 8385086 127 87 111 22 37 25 20 27 18 0 0.000222 0.999 1.000 18 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(7), B3GNT1(5), FUT1(11), FUT2(7), FUT9(10), GCNT2(26), ST8SIA1(10) 3829261 76 59 70 20 24 8 9 23 11 1 0.0900 0.999 1.000 19 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(12), CYP2C9(11) 1451222 23 21 22 5 3 8 2 9 1 0 0.292 0.999 1.000 20 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), MIOX(3), UGDH(9) 5672987 84 62 71 15 22 18 12 16 16 0 0.0117 0.999 1.000 21 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CCR5(11), CD28(5), CD3D(5), CD3E(2), CD4(4) 2096860 27 25 23 8 4 5 5 8 5 0 0.447 1.000 1.000 22 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(3), FOSB(6), GRIA2(29), PPP1R1B(1) 2306760 39 34 38 13 15 6 4 11 3 0 0.311 1.000 1.000 23 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(14), AGT(12), AGTR1(14), AGTR2(17), BDKRB2(6), KNG1(9), NOS3(23), REN(10) 6037396 105 68 90 20 30 9 11 29 26 0 0.0125 1.000 1.000 24 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(4), GALT(3), TGDS(1), UGDH(9), UGP2(12), UXS1(9) 3429686 38 33 39 7 8 2 6 11 11 0 0.281 1.000 1.000 25 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(10), BIRC3(18), CASP8(20), FADD(1), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 5215492 71 56 57 16 12 18 5 14 22 0 0.0851 1.000 1.000 26 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), LTB4R(2), P2RY1(8), P2RY2(8), P2RY6(6) 3529174 69 53 62 19 29 15 10 12 3 0 0.0255 1.000 1.000 27 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(4), GALT(3), TGDS(1), UGDH(9), UXS1(9) 2672136 26 25 27 6 6 2 4 6 8 0 0.490 1.000 1.000 28 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(7), ACAT2(9), ACYP1(2), ECHS1(4), EHHADH(15), GCDH(8), HADHA(12), SDHB(3), SDS(3) 5405606 63 50 57 14 15 10 11 14 13 0 0.0664 1.000 1.000 29 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(9), SUCLA2(9) 1413285 18 17 18 7 8 2 3 3 2 0 0.594 1.000 1.000 30 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(4), RANBP1(6), RANBP2(32), RANGAP1(4) 5440776 46 35 43 8 8 7 6 17 8 0 0.0692 1.000 1.000 31 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(6), GLUD1(4), GLUD2(22) 3043522 34 32 34 9 12 6 2 12 2 0 0.368 1.000 1.000 32 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(14), RAB11A(4), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(4), RAB6A(4), RAB9A(3) 2927576 42 33 40 12 13 6 9 6 8 0 0.224 1.000 1.000 33 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(9) 1207021 14 12 14 6 4 1 3 5 1 0 0.726 1.000 1.000 34 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(9), PAPSS1(5), PAPSS2(7), SULT1A2(4), SULT1E1(6), SULT2A1(6), SUOX(5) 4786107 42 28 38 7 11 5 4 15 7 0 0.103 1.000 1.000 35 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(6), CBS(4), CTH(6), MUT(8) 3247633 27 22 27 6 10 1 7 4 5 0 0.160 1.000 1.000 36 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(6), ST6GALNAC4(4), ST8SIA1(10) 3762847 34 31 32 9 11 7 4 6 6 0 0.205 1.000 1.000 37 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), PGD(7) 11884235 168 107 144 31 35 31 25 50 27 0 0.000534 1.000 1.000 38 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 3264996 27 24 24 7 11 4 1 8 3 0 0.324 1.000 1.000 39 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(2), CSF1(5), CSF3(3), EPO(1), IL11(6), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), IL9(2) 4283263 56 43 52 16 19 11 6 15 4 1 0.180 1.000 1.000 40 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 14 GATA3(17), IL13(2), IL4(5), MAF(9), MAP2K3(11), MAPK14(8), NFATC2(12), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 6718345 99 76 94 29 41 21 6 17 14 0 0.0862 1.000 1.000 41 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(15), PDXK(1), PDXP(1), PNPO(2), PSAT1(7) 3361327 26 22 25 7 6 7 3 6 4 0 0.341 1.000 1.000 42 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 5 ACACA(36), ACACB(40), MCAT(3), OLAH(10), OXSM(14) 8629635 103 67 91 18 31 16 17 19 19 1 0.00608 1.000 1.000 43 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(7), MMP2(18), MMP9(19), RECK(14), TIMP1(2), TIMP2(3), TIMP3(11), TIMP4(4) 5166574 82 60 78 22 41 13 6 14 8 0 0.0665 1.000 1.000 44 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(2), CCR3(11), CD4(4), HLA-DRB1(7), IL1B(5), IL4(5), IL5RA(11), IL6(7) 3331389 52 33 46 17 17 7 5 16 5 2 0.488 1.000 1.000 45 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 4 BGN(8), DCN(9), FMOD(8), KERA(9) 1998166 34 30 33 11 9 6 1 15 3 0 0.648 1.000 1.000 46 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(13), DLL1(10), FURIN(17), PSEN1(4) 3217820 44 34 44 13 16 6 5 8 9 0 0.223 1.000 1.000 47 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(6), IDI1(4), SQLE(2) 2105761 16 16 17 5 1 2 4 5 4 0 0.601 1.000 1.000 48 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(7), ACAA2(4), ACAT1(7), ACAT2(9), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), SDS(3) 5892793 71 60 65 20 14 14 13 16 14 0 0.162 1.000 1.000 49 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(4), EHHADH(15), HADHA(12), SDS(3) 3381529 34 31 30 11 8 5 7 6 8 0 0.423 1.000 1.000 50 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(1), COQ5(2), COQ6(4), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1) 2825492 18 18 21 6 6 1 7 2 2 0 0.476 1.000 1.000 51 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(6), GGPS1(5), IDI1(4), IDI2(3), SQLE(2) 2887472 24 23 24 7 4 2 4 7 7 0 0.562 1.000 1.000 52 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 2 BMP1(17), BMPR1B(15) 2024102 32 27 31 10 11 5 2 7 7 0 0.647 1.000 1.000 53 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(7), ACOX1(11), ACOX3(10), ELOVL2(9), ELOVL5(3), ELOVL6(4), FADS2(12), HADHA(12), HSD17B12(3), SCD(4) 7469545 75 60 71 17 25 8 12 18 12 0 0.0305 1.000 1.000 54 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(5), CD4(4), CD80(6), HLA-DRB1(7), IL10(2), IL2(5), IL4(5) 2352651 34 23 32 11 8 4 5 10 5 2 0.588 1.000 1.000 55 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(14), CLOCK(24), CRY1(17), CRY2(5), CSNK1E(9), PER1(13) 5727864 82 56 60 17 21 13 4 22 20 2 0.164 1.000 1.000 56 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(12), ACO1(12), ACO2(7), ACSS1(7), ACSS2(10), FH(10), IDH2(17), MDH1(8), MDH2(3), SUCLA2(9) 8714026 95 76 86 24 23 19 12 27 14 0 0.0757 1.000 1.000 57 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(15), PARK2(14), SNCA(2), SNCAIP(8), UBE2E2(4), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5) 4435755 54 42 53 17 16 2 9 20 7 0 0.409 1.000 1.000 58 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(3), AASS(14), KARS(8) 3412261 27 24 25 8 4 4 6 8 5 0 0.534 1.000 1.000 59 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 C9orf47(2), CNR1(13), CNR2(1), DNMT1(28), MTNR1A(3), MTNR1B(15), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2) 6920622 88 64 80 23 41 10 7 18 12 0 0.0149 1.000 1.000 60 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(12), ACO2(7), FH(10), IDH2(17), MDH1(8), MDH2(3), SDHB(3), SUCLA2(9) 5673949 69 63 61 20 13 14 9 21 12 0 0.293 1.000 1.000 61 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(27), GNAS(39), GNB1(3), GNGT1(1), PRKACA(2), PRKAR1A(8) 3947776 80 70 61 24 41 18 3 13 5 0 0.199 1.000 1.000 62 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(14), GBA(4), GBA3(3), LPO(10), MPO(17), PRDX6(5), TPO(36) 5518266 89 69 82 22 43 12 8 14 12 0 0.0534 1.000 1.000 63 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(6), CDK7(3), MNAT1(4), SHH(3), XPO1(9) 6040819 62 50 60 15 16 12 8 21 5 0 0.138 1.000 1.000 64 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(5), DPM2(1), EGR1(14), HRAS(4), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NGFR(5), RAF1(16) 5086719 74 56 64 23 32 9 9 14 10 0 0.143 1.000 1.000 65 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9) 3892945 46 41 42 17 5 15 6 16 4 0 0.524 1.000 1.000 66 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(8), CBS(4), CTH(6), GGT1(11), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), PAPSS1(5), PAPSS2(7), SCLY(12), SEPHS1(7) 8333402 96 68 82 24 26 10 15 20 25 0 0.0927 1.000 1.000 67 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(27), DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10) 6120079 64 49 58 14 21 18 6 9 10 0 0.0624 1.000 1.000 68 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(7), CYCS(1), GPD2(11), NDUFA1(2), SDHA(14), SDHB(3), SDHD(4), UQCRC1(4) 4494132 46 35 46 12 18 4 8 13 3 0 0.233 1.000 1.000 69 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(11), ACOX3(10), FADS2(12), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10) 7146239 74 54 70 18 30 11 8 15 10 0 0.0458 1.000 1.000 70 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(14), GBA3(3), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TPO(36), TYR(12) 6336993 104 78 95 28 48 17 10 17 12 0 0.0653 1.000 1.000 71 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), KARS(8) 5021396 52 44 47 15 8 9 10 16 9 0 0.422 1.000 1.000 72 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(11), CTH(6), GOT1(7), GOT2(2), LDHA(14), LDHB(8), LDHC(4) 4555695 52 44 44 14 16 13 6 10 7 0 0.237 1.000 1.000 73 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(1), ALAS1(12), ALAS2(12), CPO(10), FECH(4), GATA1(19), HBB(3), HMBS(5), UROD(3), UROS(5) 5728569 74 52 68 18 23 17 7 17 10 0 0.113 1.000 1.000 74 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), RAC1(2), WASF1(6), WASL(18) 5691919 72 48 69 20 21 9 11 19 12 0 0.202 1.000 1.000 75 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NFS1(6), PHPT1(2), THTPA(2), TPK1(10) 4460825 58 48 53 16 18 13 7 12 8 0 0.292 1.000 1.000 76 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(12), PON2(7), PON3(14), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 5765037 77 58 67 23 20 19 8 19 11 0 0.262 1.000 1.000 77 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(2), CTSD(6), ESR1(21), GREB1(29), HSPB2(3), MTA1(6), MTA3(4), PDZK1(2), TUBA8(5) 6286975 78 55 77 25 29 8 10 16 15 0 0.293 1.000 1.000 78 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(1), DAG1(10), GNAQ(11), ITPKA(3), ITPKB(15) 3673735 44 37 41 15 15 9 3 11 6 0 0.476 1.000 1.000 79 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(10), FOS(5), JUN(2), MAPK3(4), OPRK1(14), POLR2A(14), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 8802767 87 71 83 22 34 15 5 15 18 0 0.0858 1.000 1.000 80 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(8), ANKRD1(9), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(13), IL18(3), IL1A(1), IL1R1(7), MYOG(6), NR4A3(9), WDR1(7) 7302242 70 45 69 16 20 14 9 18 9 0 0.0669 1.000 1.000 81 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), GSR(5), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH2(17), MGST1(2), MGST2(2), MGST3(1), TXNDC12(3) 13338470 188 119 157 41 37 40 26 52 33 0 0.00354 1.000 1.000 82 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 8 CD3D(5), CD3E(2), CD4(4), FYN(17), HLA-DRB1(7), LCK(9), PTPRC(36), ZAP70(12) 5588107 92 72 79 28 21 19 14 16 20 2 0.250 1.000 1.000 83 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(11), CARS2(6), CDO1(3), CTH(6), GOT1(7), GOT2(2), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), SDS(3), SULT1B1(6), SULT1C2(6), SULT1C4(3), SULT4A1(6) 8615564 98 70 88 25 31 19 12 23 13 0 0.0897 1.000 1.000 84 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(3), GRB2(11), HBXIP(4), HRAS(4), PTK2B(13), SHC1(14), SOS1(16), SRC(3) 5976285 68 58 57 19 8 19 9 15 16 1 0.431 1.000 1.000 85 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(4), GBA3(3), GGT1(11), SHMT1(7), SHMT2(5) 3523686 31 30 27 11 8 1 3 4 15 0 0.852 1.000 1.000 86 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 194 ABI2(5), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), APC(683), ARAF(10), ARHGEF1(15), ARHGEF12(12), ARHGEF4(9), ARHGEF6(19), ARHGEF7(23), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(4), BAIAP2(7), BCAR1(6), BDKRB1(4), BDKRB2(6), BRAF(125), CD14(6), CDC42(3), CFL1(2), CFL2(2), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CRKL(5), CSK(5), CYFIP1(16), CYFIP2(10), DIAPH1(7), DIAPH2(28), DIAPH3(19), DOCK1(24), EGF(8), EGFR(115), EZR(3), F2(10), F2R(11), FGD1(21), FGD3(16), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR4(12), FN1(58), GIT1(4), GNA12(7), GNA13(3), GRLF1(19), GSN(4), HRAS(4), IQGAP1(31), IQGAP2(32), IQGAP3(24), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LIMK1(8), LIMK2(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MOS(10), MRAS(4), MSN(9), MYH10(17), MYH14(25), MYH9(43), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), NCKAP1(17), NCKAP1L(25), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PFN2(4), PFN4(6), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R12B(33), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RDX(16), ROCK1(35), ROCK2(20), RRAS(2), RRAS2(7), SCIN(10), SLC9A1(12), SOS1(16), SOS2(17), SSH1(15), SSH2(16), SSH3(4), TIAM1(42), TIAM2(26), TMSL3(2), VAV1(24), VAV2(20), VAV3(30), VCL(10), WAS(4), WASF1(6), WASF2(5), WASL(18) 183473775 3565 472 2799 1224 719 877 427 754 620 168 0.0951 1.000 1.000 87 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 132 APC(683), AXIN1(10), AXIN2(27), BTRC(11), CACYBP(4), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(6), CHD8(37), CREBBP(81), CSNK1A1(3), CSNK1A1L(9), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(14), CTNNB1(120), CTNNBIP1(1), CUL1(17), CXXC4(2), DAAM1(10), DAAM2(20), DKK1(9), DKK2(27), DKK4(8), DVL2(12), DVL3(10), EP300(56), FBXW11(13), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LEF1(9), LRP5(11), LRP6(34), MAP3K7(9), MAPK10(18), MAPK8(17), MAPK9(13), MMP7(10), MYC(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NKD1(6), NLK(12), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRICKLE1(24), PRICKLE2(18), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PSEN1(4), RAC1(2), RAC2(1), RAC3(2), RBX1(1), ROCK1(35), ROCK2(20), RUVBL1(9), SENP2(4), SFRP1(3), SFRP2(10), SFRP4(9), SFRP5(1), SIAH1(2), SKP1(2), SMAD4(191), TBL1X(9), TBL1XR1(11), TCF7(15), TCF7L1(8), VANGL1(15), VANGL2(9), WIF1(5), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4) 98737262 2285 468 1741 748 489 532 234 408 459 163 0.0142 1.000 1.000 88 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(11), APC(683), AR(26), ASAH1(4), BRAF(125), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(10), EGFR(115), GNA11(8), GNA15(6), GNAI1(5), GNAQ(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), MAPK10(18), MAPK14(8), PHKA2(19), PIK3CA(344), PIK3CD(11), PIK3R1(62), PITX2(2), PTX3(3), RAF1(16), SRC(3) 35303546 1683 456 1080 552 197 528 201 305 295 157 0.0116 1.000 1.000 89 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 55 APC(683), AXIN1(10), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), CTNNB1(120), DVL2(12), DVL3(10), FBXW2(6), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LDLR(11), MAPK10(18), MAPK9(13), MYC(5), PAFAH1B1(6), PLAU(7), PPP2R5C(6), PPP2R5E(8), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), RAC1(2), SFRP4(9), TCF7(15), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4) 36639766 1289 448 891 415 191 329 114 197 303 155 0.0294 1.000 1.000 90 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(11), APC(683), AXIN1(10), CCND1(2), CD14(6), CTNNB1(120), FZD1(9), GJA1(9), GNAI1(5), GSK3B(17), IRAK1(6), LBP(8), LEF1(9), LY96(4), MYD88(4), NFKB1(11), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), RELA(10), TIRAP(5), TLR4(18), TOLLIP(5), WNT1(7) 19556205 1372 444 810 433 107 470 170 193 275 157 7.66e-05 1.000 1.000 91 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 28 AKT1(11), AKT2(8), AKT3(8), ANKRD6(12), APC(683), AXIN1(10), AXIN2(27), CER1(6), CSNK1A1(3), CTNNB1(120), DACT1(19), DKK1(9), DKK2(27), DKK3(9), DKK4(8), FSTL1(10), GSK3A(6), GSK3B(17), LRP1(53), MVP(10), NKD1(6), PIN1(2), PSEN1(4), PTPRA(6), SENP2(4), SFRP1(3), TSHB(2), WIF1(5) 26192383 1088 442 711 331 126 282 97 162 264 157 0.0141 1.000 1.000 92 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 189 ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), BAD(1), BCAR1(6), BCL2(2), BIRC2(7), BIRC3(18), BRAF(125), CAPN2(10), CAV1(1), CAV2(4), CAV3(4), CCND1(2), CCND2(3), CCND3(2), CDC42(3), CHAD(10), COL11A1(65), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), CRKL(5), CTNNB1(120), DIAPH1(7), DOCK1(24), EGF(8), EGFR(115), ELK1(4), ERBB2(37), FARP2(13), FIGF(6), FLNA(31), FLNB(40), FLNC(39), FLT1(43), FN1(58), FYN(17), GRB2(11), GRLF1(19), GSK3B(17), HGF(17), HRAS(4), IBSP(6), IGF1(6), IGF1R(22), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), JUN(2), KDR(42), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), MAP2K1(12), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MET(55), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PDPK1(4), PGF(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PRKCA(8), PRKCG(24), PTEN(333), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF1(19), RELN(95), ROCK1(35), ROCK2(20), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SPP1(4), SRC(3), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TLN1(23), TLN2(17), TNC(41), TNN(33), TNR(48), VASP(4), VAV1(24), VAV2(20), VAV3(30), VCL(10), VEGFA(5), VEGFB(3), VEGFC(15), VTN(13), VWF(36), ZYX(5) 238284017 4202 440 3518 1638 1012 1113 559 972 522 24 0.700 1.000 1.000 93 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 28 ACVR1(9), APC(683), ATF2(7), AXIN1(10), BMP10(15), BMP2(9), BMP4(6), BMP5(9), BMP7(15), CHRD(16), CTNNB1(120), FZD1(9), GATA4(4), GSK3B(17), MAP3K7(9), MEF2C(15), MYL2(2), NPPA(1), NPPB(5), RFC1(25), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), WNT1(7) 21480701 1070 434 699 324 120 274 95 170 256 155 0.00169 1.000 1.000 94 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(683), AXIN1(10), CREBBP(81), CTNNB1(120), EP300(56), FZD1(9), GSK3B(17), HDAC1(5), LDB1(9), LEF1(9), PITX2(2), TRRAP(70), WNT1(7) 22125437 1078 434 690 342 105 309 101 145 263 155 0.00516 1.000 1.000 95 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(683), AXIN1(10), BTRC(11), CCND1(2), CREBBP(81), CSNK1A1(3), CSNK1D(15), CSNK2A1(7), CTBP1(5), CTNNB1(120), FZD1(9), GSK3B(17), HDAC1(5), MAP3K7(9), MYC(5), NLK(12), PPARD(5), PPP2CA(3), TLE1(7), WIF1(5), WNT1(7) 19002093 1021 432 648 321 81 278 102 149 256 155 0.00606 1.000 1.000 96 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(4), AKT1(11), APC(683), ASAH1(4), CAMP(1), CAV3(4), DAG1(10), DLG4(10), EPHB2(16), GNAI1(5), GNAQ(11), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(5), RYR1(70) 30404752 1010 430 708 325 153 220 91 146 244 156 0.0508 1.000 1.000 97 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(683), CREBBP(81), EP300(56), MAP2K1(12), MAP3K7(9), MAPK3(4), SKIL(9), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26) 16968923 914 425 580 283 85 241 76 115 243 154 0.00645 1.000 1.000 98 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 164 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY7(13), ADCY8(34), ADCY9(22), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), ATP2A1(24), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), ATP2B4(26), AVPR1A(15), AVPR1B(5), BDKRB1(4), BDKRB2(6), BST1(3), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CCKAR(9), CCKBR(16), CD38(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM5(6), CHRNA7(1), CYSLTR1(9), CYSLTR2(18), DRD1(9), EDNRA(9), EDNRB(19), EGFR(115), ERBB2(37), ERBB3(32), ERBB4(65), F2R(11), GNA11(8), GNA14(13), GNA15(6), GNAL(5), GNAQ(11), GNAS(39), GRIN1(5), GRIN2A(55), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), GRPR(4), HRH1(4), HRH2(16), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), LHCGR(27), MYLK(33), MYLK2(10), NOS1(31), NOS3(23), NTSR1(5), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), PDE1A(10), PDE1B(11), PDE1C(19), PDGFRA(64), PDGFRB(21), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PLN(1), PPID(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTAFR(1), PTGFR(8), PTK2B(13), RYR1(70), RYR2(138), RYR3(84), SLC25A4(4), SLC25A5(10), SLC8A1(24), SLC8A2(16), SLC8A3(17), SPHK1(3), SPHK2(5), TACR1(9), TACR2(4), TACR3(18), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(17), VDAC1(6), VDAC2(4), VDAC3(2) 172482049 2744 424 2576 1007 951 533 300 597 352 11 0.267 1.000 1.000 99 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 10 ADAM17(13), APC(683), AXIN1(10), BTRC(11), CTNNB1(120), DLL1(10), FZD1(9), GSK3B(17), PSEN1(4), WNT1(7) 10915034 884 422 528 263 46 245 78 124 236 155 0.000515 1.000 1.000 100 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 22 APC(683), ASAH1(4), CAMP(1), CASP3(4), CERK(3), CREB1(3), CREB3(6), CREB5(8), DAG1(10), EPHB2(16), FOS(5), GNAQ(11), ITPKA(3), ITPKB(15), JUN(2), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13) 16815728 843 419 538 243 61 205 67 119 237 154 0.00106 1.000 1.000 101 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 219 ADCYAP1R1(5), ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), ADRA1A(12), ADRA1B(6), ADRA2A(5), ADRA2B(7), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), C5AR1(8), CALCR(12), CALCRL(9), CCKAR(9), CCKBR(16), CGA(3), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CNR1(13), CNR2(1), CRHR1(6), CRHR2(6), CTSG(5), CYSLTR1(9), CYSLTR2(18), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2(10), F2R(11), F2RL1(8), F2RL2(8), FPR1(8), FSHB(6), FSHR(19), GABBR1(20), GABBR2(23), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GABRB1(11), GABRB2(10), GABRB3(19), GABRD(6), GABRE(12), GABRG1(21), GABRG2(20), GABRG3(12), GABRP(13), GABRQ(19), GABRR1(5), GABRR2(8), GALR1(5), GH1(5), GH2(6), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(11), GLP2R(10), GLRA1(10), GLRA2(9), GLRA3(13), GLRB(14), GNRHR(9), GPR156(17), GPR35(3), GPR50(9), GPR63(7), GPR83(7), GRIA1(38), GRIA2(29), GRIA3(15), GRIA4(46), GRID1(30), GRID2(28), GRIK1(13), GRIK2(49), GRIK3(33), GRIK4(21), GRIK5(15), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRIN3A(19), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM6(27), GRM7(36), GRM8(29), GRPR(4), GZMA(11), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HRH4(6), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LEP(1), LEPR(21), LHB(3), LHCGR(27), LTB4R(2), MAS1(3), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), MCHR1(8), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPBWR1(7), NPBWR2(1), NPFFR1(1), NPFFR2(14), NPY1R(6), NPY2R(12), NPY5R(7), NR3C1(11), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), P2RY1(8), P2RY10(15), P2RY14(11), P2RY2(8), P2RY4(8), P2RY6(6), PARD3(13), PPYR1(8), PRL(4), PRLHR(5), PRLR(10), PRSS1(7), PRSS3(6), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTH2R(16), RXFP1(7), RXFP2(21), SCTR(6), SSTR1(12), SSTR2(6), SSTR4(14), TAAR1(7), TAAR2(7), TAAR5(10), TAAR6(7), TAAR8(6), TAAR9(6), TACR1(9), TACR2(4), TACR3(18), THRA(6), THRB(14), TRHR(9), TRPV1(11), TSHB(2), VIPR1(7), VIPR2(11) 140494298 2484 418 2247 909 870 436 275 605 293 5 0.0629 1.000 1.000 102 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTB(4), ACTG1(6), CHAD(10), COL11A1(65), COL11A2(19), COL17A1(16), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), DES(6), DSC1(14), DSC2(17), DSC3(13), DSG1(23), DSG2(12), DSG3(17), DSG4(29), FN1(58), GJA1(9), GJA10(17), GJA3(5), GJA4(3), GJA5(7), GJA8(22), GJA9(6), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GJB7(4), GJC1(10), GJC3(4), GJD2(5), GJD4(4), IBSP(6), INA(9), ITGA6(16), ITGB4(18), KRT1(19), KRT10(7), KRT12(7), KRT13(11), KRT14(10), KRT15(9), KRT16(5), KRT17(11), KRT18(3), KRT19(4), KRT2(15), KRT20(3), KRT23(9), KRT24(5), KRT25(12), KRT27(3), KRT28(5), KRT3(13), KRT31(12), KRT32(7), KRT33A(8), KRT33B(6), KRT34(11), KRT35(7), KRT36(5), KRT37(11), KRT38(3), KRT39(9), KRT4(36), KRT40(2), KRT5(8), KRT6A(8), KRT6B(6), KRT6C(7), KRT7(6), KRT71(9), KRT72(14), KRT73(14), KRT74(9), KRT75(14), KRT76(9), KRT77(6), KRT78(6), KRT79(8), KRT8(4), KRT81(3), KRT82(7), KRT83(4), KRT84(12), KRT85(15), KRT86(4), KRT9(13), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), LMNA(1), LMNB1(11), LMNB2(3), NES(30), PRPH(3), RELN(95), SPP1(4), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VIM(9), VTN(13), VWF(36) 159764754 2186 396 2023 863 762 314 297 497 313 3 0.856 1.000 1.000 103 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 234 ACVR1C(11), AKT1(11), AKT2(8), AKT3(8), ARRB1(4), ARRB2(1), ATF2(7), ATF4(4), BDNF(5), BRAF(125), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CACNA2D1(31), CACNA2D2(9), CACNA2D3(24), CACNA2D4(13), CACNB1(6), CACNB2(11), CACNB3(3), CACNB4(4), CACNG1(5), CACNG2(6), CACNG3(12), CACNG4(4), CACNG5(9), CACNG6(4), CACNG7(9), CACNG8(2), CASP3(4), CD14(6), CDC25B(11), CDC42(3), CHUK(27), CRKL(5), DAXX(18), DDIT3(5), DUSP1(7), DUSP10(6), DUSP16(11), DUSP3(4), DUSP4(6), DUSP5(2), DUSP6(7), DUSP7(8), DUSP9(9), ECSIT(7), EGF(8), EGFR(115), ELK1(4), ELK4(5), FAS(9), FASLG(3), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR4(12), FLNA(31), FLNB(40), FLNC(39), FOS(5), GADD45G(1), GNA12(7), GRB2(11), HRAS(4), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAPT(11), MAX(5), MEF2C(15), MKNK1(4), MKNK2(7), MOS(10), MRAS(4), MYC(5), NF1(138), NFATC2(12), NFATC4(12), NFKB1(11), NFKB2(6), NLK(12), NR4A1(3), NTF3(3), NTRK1(17), NTRK2(25), PAK1(11), PAK2(15), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PPM1A(9), PPM1B(6), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PPP5C(9), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTPN5(8), PTPN7(4), PTPRR(16), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF2(35), RASA1(24), RASA2(17), RASGRF1(25), RASGRF2(26), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KA6(18), RRAS(2), RRAS2(7), SOS1(16), SOS2(17), SRF(4), STK3(8), STK4(9), STMN1(2), TAOK1(17), TAOK2(14), TAOK3(20), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF1A(4), TRAF2(8), TRAF6(4), ZAK(12) 181328728 2748 389 2458 934 790 599 311 630 403 15 0.0265 1.000 1.000 104 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(31), ABL2(20), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BRAF(125), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CBL(45), CBLB(17), CBLC(3), CDKN1A(2), CDKN1B(6), CRKL(5), EGF(8), EGFR(115), ELK1(4), ERBB2(37), ERBB3(32), ERBB4(65), EREG(3), GAB1(15), GRB2(11), GSK3B(17), HBEGF(1), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYC(5), NCK1(1), NCK2(5), NRG1(33), NRG2(8), NRG3(18), NRG4(2), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), RAF1(16), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SRC(3), STAT5A(10), STAT5B(20) 68063061 1569 373 1174 564 288 507 239 333 199 3 0.309 1.000 1.000 105 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 83 CD36(3), CD44(6), CD47(8), CHAD(10), COL11A1(65), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), DAG1(10), FN1(58), FNDC1(44), FNDC3A(15), FNDC4(6), FNDC5(2), GP5(9), GP6(13), GP9(1), HMMR(17), HSPG2(27), IBSP(6), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), RELN(95), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SPP1(4), SV2A(24), SV2B(11), SV2C(13), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VTN(13), VWF(36) 143247103 1883 372 1774 762 628 277 248 456 268 6 0.888 1.000 1.000 106 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(21), ATP1B1(4), ATP1B2(4), ATP1B3(4), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1S(34), CACNB1(6), CACNB3(3), CALM2(1), CALM3(1), CALR(2), CAMK1(9), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CASQ1(5), CASQ2(11), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), GJA1(9), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), ITPR1(43), ITPR2(49), ITPR3(44), KCNB1(22), KCNJ3(11), KCNJ5(11), MIB1(13), MYCBP(1), NME7(9), PEA15(1), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLN(1), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SLC8A3(17), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1) 122428045 1734 364 1694 642 642 271 191 371 250 9 0.311 1.000 1.000 107 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 125 ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), AMOTL1(15), ASH1L(64), CASK(11), CDC42(3), CDK4(4), CGN(18), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTTN(5), EPB41(11), EPB41L1(14), EPB41L2(12), EPB41L3(35), EXOC3(3), EXOC4(22), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), HCLS1(16), HRAS(4), IGSF5(16), INADL(18), JAM2(2), JAM3(9), LLGL1(7), LLGL2(8), MAGI1(31), MAGI2(32), MAGI3(10), MLLT4(21), MPDZ(26), MPP5(7), MRAS(4), MYH1(47), MYH10(17), MYH11(49), MYH13(28), MYH14(25), MYH15(37), MYH2(42), MYH3(46), MYH4(30), MYH6(34), MYH7(28), MYH7B(31), MYH8(47), MYH9(43), MYL2(2), MYL7(1), MYL9(3), OCLN(2), PARD3(13), PARD6A(2), PARD6B(2), PARD6G(7), PPM1J(3), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP2R3A(16), PPP2R4(4), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PTEN(333), RAB13(1), RAB3B(3), RRAS(2), RRAS2(7), SPTAN1(30), SRC(3), SYMPK(11), TJAP1(5), TJP1(25), TJP2(17), TJP3(12), VAPA(2), YES1(10), ZAK(12) 128194095 2031 364 1731 716 567 508 246 423 269 18 0.302 1.000 1.000 108 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 143 AKT1(11), AKT2(8), AKT3(8), BCL2L1(1), CBL(45), CBLB(17), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(81), CSF2RB(13), CSF3(3), CSF3R(19), EP300(56), EPO(1), EPOR(2), GH1(5), GH2(6), GHR(12), GRB2(11), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL13RA2(17), IL15(1), IL15RA(1), IL19(3), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL9(2), IRF9(6), JAK1(22), JAK2(55), JAK3(31), LEP(1), LEPR(21), LIF(1), LIFR(41), MPL(9), MYC(5), OSM(4), OSMR(22), PIAS1(4), PIAS2(5), PIAS3(10), PIAS4(2), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIM1(4), PRL(4), PRLR(10), PTPN11(41), PTPN6(4), SOCS2(4), SOCS4(1), SOCS5(12), SOCS7(1), SOS1(16), SOS2(17), SPRED1(10), SPRED2(10), SPRY1(10), SPRY2(2), SPRY4(7), STAM(4), STAM2(4), STAT1(17), STAT2(12), STAT3(10), STAT4(13), STAT5A(10), STAT5B(20), STAT6(4), TPO(36), TSLP(3), TYK2(5) 96589797 1667 363 1312 583 338 488 239 385 209 8 0.139 1.000 1.000 109 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 103 ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), BCAR1(6), CDC42(3), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTNND1(19), CXCL12(2), CXCR4(7), CYBB(6), ESAM(6), EZR(3), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), GRLF1(19), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), ITK(26), JAM2(2), JAM3(9), MAPK12(4), MAPK13(6), MAPK14(8), MLLT4(21), MMP2(18), MMP9(19), MSN(9), MYL2(2), MYL7(1), MYL9(3), NCF1(4), NCF2(10), NCF4(5), NOX1(4), NOX3(14), OCLN(2), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAC1(2), RAC2(1), RAP1A(2), RAP1B(2), RAPGEF3(8), RAPGEF4(12), RASSF5(6), RHOH(5), ROCK1(35), ROCK2(20), SIPA1(10), TXK(12), VASP(4), VAV1(24), VAV2(20), VAV3(30), VCAM1(15), VCL(10) 79255893 1536 362 1210 566 358 434 203 339 195 7 0.606 1.000 1.000 110 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 235 ACVR1(9), ACVR2B(14), AMHR2(4), BMP2(9), BMP7(15), BMPR1B(15), CCL11(2), CCL13(1), CCL14(4), CCL15(2), CCL16(2), CCL17(1), CCL18(2), CCL22(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL28(4), CCL4(1), CCL7(2), CCL8(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CD27(4), CD40(7), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(5), CSF1R(16), CSF2RB(13), CSF3(3), CSF3R(19), CX3CL1(5), CX3CR1(6), CXCL1(1), CXCL10(2), CXCL11(4), CXCL12(2), CXCL14(2), CXCL16(3), CXCL5(6), CXCL6(1), CXCL9(7), CXCR3(5), CXCR4(7), CXCR6(1), EDA(5), EDA2R(4), EDAR(8), EGF(8), EGFR(115), EPO(1), EPOR(2), FAS(9), FASLG(3), FLT1(43), FLT3(36), FLT3LG(1), FLT4(18), GDF5(13), GH1(5), GH2(6), GHR(12), HGF(17), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL15(1), IL15RA(1), IL17A(3), IL17B(1), IL17RA(8), IL17RB(8), IL18(3), IL18R1(16), IL18RAP(12), IL19(3), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL1RAP(7), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL25(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL8(6), IL9(2), INHBA(21), INHBB(3), INHBC(4), INHBE(3), KDR(42), KIT(161), KITLG(3), LEP(1), LEPR(21), LIF(1), LIFR(41), LTA(1), LTBR(5), MET(55), MPL(9), NGFR(5), OSM(4), OSMR(22), PDGFB(2), PDGFC(10), PDGFRA(64), PDGFRB(21), PF4(3), PLEKHO2(7), PPBP(6), PRL(4), PRLR(10), RELT(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFRSF11A(6), TNFRSF11B(7), TNFRSF13B(7), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFRSF8(8), TNFRSF9(10), TNFSF10(3), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(4), TNFSF14(4), TNFSF15(3), TNFSF4(6), TNFSF8(6), TPO(36), TSLP(3), VEGFA(5), VEGFB(3), VEGFC(15), XCL1(1), XCL2(4), XCR1(6) 114579528 1828 361 1619 646 445 460 220 463 235 5 0.136 1.000 1.000 111 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 123 ACACA(36), ACACB(40), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BRAF(125), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBL(45), CBLB(17), CBLC(3), CRKL(5), ELK1(4), EXOC7(4), FBP1(1), FBP2(5), FLOT1(7), FLOT2(2), FOXO1(8), G6PC(5), G6PC2(3), GCK(6), GRB2(11), GSK3B(17), GYS1(6), GYS2(17), HRAS(4), IKBKB(9), INPP5D(10), INSR(21), IRS1(21), IRS4(36), LIPE(11), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MKNK1(4), MKNK2(7), PCK1(6), PCK2(6), PDE3A(21), PDE3B(10), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PKLR(12), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R3A(45), PPP1R3B(4), PPP1R3C(6), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACA(2), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCI(25), PRKCZ(4), PRKX(3), PTPN1(11), PTPRF(23), PYGB(15), PYGL(8), PYGM(12), RAF1(16), RAPGEF1(19), RHEB(5), RHOQ(6), RPS6(3), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SLC2A4(8), SOCS2(4), SOCS4(1), SORBS1(15), SOS1(16), SOS2(17), SREBF1(8), TRIP10(5), TSC1(18), TSC2(17) 101810232 1716 360 1348 594 405 456 243 394 214 4 0.0627 1.000 1.000 112 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS1(15), CDS2(10), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), FN3K(1), IMPA1(4), IMPA2(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5D(10), INPP5E(3), INPPL1(16), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), OCRL(21), PI4KA(29), PI4KB(5), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3C3(29), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PRKCA(8), PRKCG(24), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15) 81870157 1678 358 1286 603 344 559 231 329 203 12 0.396 1.000 1.000 113 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(31), ACTN1(13), ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGEF6(19), ARHGEF7(23), BCAR1(6), BRAF(125), CAV1(1), CDC42(3), CDKN2A(9), CSE1L(10), DOCK1(24), EPHB2(16), FYN(17), GRB2(11), GRB7(3), GRLF1(19), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGB3BP(3), MAP3K11(12), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MRAS(4), MYLK(33), MYLK2(10), P4HB(6), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CA(344), PIK3CB(6), PKLR(12), PLCG1(19), PLCG2(28), PTEN(333), PTK2(24), RAF1(16), RALA(8), RHO(5), ROCK1(35), ROCK2(20), SHC1(14), SOS1(16), SOS2(17), SRC(3), TERF2IP(4), TLN1(23), TLN2(17), VASP(4), WAS(4), ZYX(5) 80363437 1735 357 1295 654 279 565 251 394 231 15 0.666 1.000 1.000 114 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 121 ABL1(31), ABLIM1(11), ABLIM2(7), ABLIM3(17), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CFL2(2), CXCL12(2), CXCR4(7), DCC(42), DPYSL2(11), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(6), EFNB1(6), EFNB2(1), EFNB3(11), EPHA1(11), EPHA2(12), EPHA3(70), EPHA4(26), EPHA5(47), EPHA6(28), EPHA7(45), EPHA8(19), EPHB1(38), EPHB2(16), EPHB3(12), EPHB4(15), EPHB6(15), FES(7), FYN(17), GNAI1(5), GNAI2(2), GNAI3(2), GSK3B(17), HRAS(4), ITGB1(13), L1CAM(17), LIMK1(8), LIMK2(13), LRRC4C(17), MAPK1(3), MAPK3(4), MET(55), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NGEF(19), NRP1(12), NTN1(5), NTN4(10), NTNG1(17), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLXNA1(22), PLXNA2(26), PLXNA3(24), PLXNB1(22), PLXNB2(28), PLXNB3(25), PLXNC1(20), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RAC3(2), RASA1(24), RGS3(25), RND1(3), ROBO1(32), ROBO3(12), ROCK1(35), ROCK2(20), SEMA3A(21), SEMA3B(7), SEMA3C(18), SEMA3D(29), SEMA3E(22), SEMA3F(13), SEMA3G(10), SEMA4A(13), SEMA4B(5), SEMA4C(5), SEMA4D(18), SEMA4F(14), SEMA4G(11), SEMA5A(21), SEMA5B(26), SEMA6A(9), SEMA6B(8), SEMA6C(13), SEMA6D(15), SEMA7A(3), SLIT1(31), SLIT2(33), SLIT3(25), SRGAP1(25), SRGAP2(9), SRGAP3(21), UNC5A(9), UNC5B(10), UNC5C(17), UNC5D(22) 120612345 1785 354 1652 649 585 335 192 393 272 8 0.490 1.000 1.000 115 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 118 ARAF(10), BID(2), BRAF(125), CASP3(4), CD244(7), CD247(3), CD48(2), FAS(9), FASLG(3), FCGR3A(5), FCGR3B(2), FYN(17), GRB2(11), GZMB(5), HCST(2), HLA-C(13), HLA-E(4), HLA-G(13), HRAS(4), ICAM1(4), ICAM2(6), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), ITGAL(21), ITGB2(18), KIR2DL1(10), KIR2DL4(5), KIR3DL1(10), KIR3DL2(7), KLRC1(2), KLRC2(2), KLRC3(8), KLRD1(3), KLRK1(8), LAT(3), LCK(9), LCP2(10), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MICB(4), NCR1(3), NCR2(2), NCR3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), PAK1(11), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRF1(8), PRKCA(8), PRKCG(24), PTK2B(13), PTPN11(41), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SH2D1A(3), SH2D1B(1), SH3BP2(7), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SYK(8), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFSF10(3), TYROBP(1), ULBP1(7), ULBP2(2), ULBP3(6), VAV1(24), VAV2(20), VAV3(30), ZAP70(12) 72971449 1429 351 1054 501 291 423 197 328 186 4 0.169 1.000 1.000 116 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 134 ACTA1(14), ACTA2(3), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADM(5), ARRB1(4), ARRB2(1), ATF1(6), ATF2(7), ATF3(1), ATF4(4), ATF5(2), ATP2A2(17), ATP2A3(13), CACNB3(3), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CNN1(5), CNN2(4), CORIN(21), CREB3(6), CRHR1(6), DGKZ(9), ETS2(5), FOS(5), GABPA(14), GABPB2(4), GBA2(15), GJA1(9), GNAQ(11), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), GSTO1(2), GUCA2B(3), GUCY1A3(33), IGFBP1(2), IGFBP2(3), IGFBP3(8), IGFBP4(4), IGFBP6(2), IL1B(5), IL6(7), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), MIB1(13), MYL2(2), MYL4(4), MYLK2(10), NFKB1(11), NOS1(31), NOS3(23), OXTR(3), PDE4B(13), PDE4D(9), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLCD1(10), PLCG1(19), PLCG2(28), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RAMP1(2), RAMP2(2), RAMP3(7), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RLN1(4), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SP1(7), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1) 108292599 1512 351 1467 517 519 233 188 342 224 6 0.0410 1.000 1.000 117 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA1(14), ACTA2(3), ACTN2(19), ACTN3(6), ACTN4(8), DES(6), DMD(85), FAM48A(13), MYBPC1(12), MYBPC2(16), MYBPC3(15), MYH3(46), MYH6(34), MYH7(28), MYH8(47), MYL2(2), MYL3(1), MYL4(4), MYL9(3), MYOM1(35), NEB(106), TMOD1(8), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(3), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(8), TPM3(7), TPM4(9), TTN(882), VIM(9) 80510551 1450 350 1322 421 406 293 195 423 114 19 3.55e-05 1.000 1.000 118 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 69 ACP1(5), ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), ACVR1C(11), BAIAP2(7), CDC42(3), CREBBP(81), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTNND1(19), EGFR(115), EP300(56), ERBB2(37), FARP2(13), FER(18), FGFR1(22), FYN(17), IGF1R(22), INSR(21), IQGAP1(31), LEF1(9), LMO7(33), MAP3K7(9), MAPK1(3), MAPK3(4), MET(55), MLLT4(21), NLK(12), PARD3(13), PTPN1(11), PTPN6(4), PTPRB(21), PTPRF(23), PTPRJ(18), PTPRM(48), PVRL1(9), PVRL2(5), PVRL3(5), PVRL4(11), RAC1(2), RAC2(1), RAC3(2), SMAD4(191), SNAI1(6), SNAI2(11), SORBS1(15), SRC(3), SSX2IP(9), TCF7(15), TCF7L1(8), TGFBR1(20), TGFBR2(26), TJP1(25), VCL(10), WAS(4), WASF1(6), WASF2(5), WASF3(17), WASL(18), YES1(10) 76674455 1482 346 1226 522 349 413 186 325 204 5 0.161 1.000 1.000 119 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRB1(4), CSNK1D(15), DRD1(9), DRD2(9), EGF(8), EGFR(115), GJA1(9), GJD2(5), GNA11(8), GNAI1(5), GNAI2(2), GNAI3(2), GNAQ(11), GNAS(39), GRB2(11), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), HTR2A(24), HTR2B(7), HTR2C(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAP2K5(6), MAP3K2(9), MAPK1(3), MAPK3(4), MAPK7(6), NPR1(18), NPR2(17), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), PRKX(3), RAF1(16), SOS1(16), SOS2(17), SRC(3), TJP1(25), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10) 86835430 1383 346 1256 505 446 292 179 315 147 4 0.203 1.000 1.000 120 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 88 AKT1(11), AKT2(8), AKT3(8), BCL10(8), CARD11(59), CBL(45), CBLB(17), CBLC(3), CD247(3), CD28(5), CD3D(5), CD3E(2), CD4(4), CD40LG(10), CD8A(2), CD8B(4), CDC42(3), CDK4(4), CHUK(27), CTLA4(5), FOS(5), FYN(17), GRAP2(7), GRB2(11), HRAS(4), ICOS(2), IFNG(3), IKBKB(9), IKBKG(2), IL10(2), IL2(5), IL4(5), ITK(26), JUN(2), LAT(3), LCK(9), LCP2(10), MALT1(13), MAP3K14(6), MAP3K8(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDCD1(2), PDK1(7), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCQ(16), PTPN6(4), PTPRC(36), RASGRP1(8), SOS1(16), SOS2(17), TEC(10), TNF(2), VAV1(24), VAV2(20), VAV3(30), ZAP70(12) 66195292 1270 346 983 427 271 401 189 246 161 2 0.0168 1.000 1.000 121 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 78 ACVR1(9), ACVRL1(8), AKT1(11), AURKB(6), BUB1(16), CDKL1(6), CDKL2(16), CDS1(15), CDS2(10), CLK1(10), CLK2(3), CLK4(17), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), IMPA1(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MAP3K10(11), MOS(10), NEK1(20), NEK3(10), OCRL(21), PAK4(6), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CA(344), PIK3CB(6), PIK3CG(41), PIM2(1), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28), PLK3(3), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKG1(18), RAF1(16), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KB1(9), STK11(38), TGFBR1(20), VRK1(7) 72321135 1325 345 1030 465 327 370 195 267 164 2 0.284 1.000 1.000 122 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(31), ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), ATM(237), ATR(53), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDC14A(14), CDC14B(6), CDC16(6), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(6), CDC26(1), CDC27(21), CDC6(10), CDC7(25), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CHEK1(11), CHEK2(30), CREBBP(81), CUL1(17), DBF4(11), E2F2(7), E2F3(6), EP300(56), ESPL1(23), FZR1(4), GADD45G(1), GSK3B(17), HDAC1(5), HDAC2(8), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTTG1(2), RB1(139), RBL1(21), RBL2(24), RBX1(1), SFN(1), SKP1(2), SKP2(3), SMAD4(191), SMC1A(21), SMC1B(28), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), WEE1(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 91130046 1600 342 1276 559 305 476 156 365 275 23 0.453 1.000 1.000 123 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2L1(1), CDC42(3), CDK2(5), CDKN1B(6), CDKN2A(9), CREB1(3), CREB3(6), CREB5(8), EBP(6), ERBB4(65), F2RL2(8), GAB1(15), GRB2(11), GSK3A(6), GSK3B(17), IGF1(6), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), MET(55), MYC(5), NOLC1(9), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARD3(13), PARD6A(2), PDK1(7), PIK3CA(344), PIK3CD(11), PPP1R13B(10), PREX1(27), PTEN(333), PTK2(24), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SLC2A4(8), SOS1(16), SOS2(17), TSC1(18), TSC2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 49803085 1380 341 1000 517 203 511 220 271 166 9 0.458 1.000 1.000 124 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 150 ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCBP2(14), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CCRL1(7), CCRL2(5), CHML(25), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CMKLR1(8), CNR1(13), CNR2(1), CX3CR1(6), CXCR3(5), CXCR4(7), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2R(11), F2RL1(8), F2RL2(8), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GPR17(3), GPR173(3), GPR174(10), GPR3(3), GPR35(3), GPR37(15), GPR37L1(8), GPR4(7), GPR44(2), GPR50(9), GPR6(8), GPR63(7), GPR77(4), GPR83(7), GPR85(7), GPR87(12), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LHCGR(27), LTB4R(2), MAS1(3), MC1R(2), MC3R(14), MC4R(7), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPN1SW(8), OPN3(7), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OR10A5(3), OR12D3(4), OR1C1(11), OR1F1(4), OR1Q1(5), OR2H1(5), OR7A5(6), OR8B8(6), OXTR(3), P2RY1(8), P2RY10(15), P2RY12(6), P2RY14(11), P2RY2(8), P2RY6(6), PPYR1(8), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), RGR(4), RHO(5), RRH(7), SSTR1(12), SSTR2(6), SSTR4(14), SUCNR1(6), TRHR(9) 75078166 1257 337 1134 466 457 236 154 290 119 1 0.0173 1.000 1.000 125 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(31), ATM(237), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDAN1(9), CDC14A(14), CDC14B(6), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(6), CDC6(10), CDC7(25), CDK2(5), CDK4(4), CDKN1A(2), CDKN2A(9), CHEK1(11), CHEK2(30), DTX4(8), E2F2(7), E2F3(6), E2F4(2), E2F5(6), E2F6(4), EP300(56), ESPL1(23), GSK3B(17), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), HDAC8(3), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MPEG1(8), MPL(9), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTPRA(6), PTTG1(2), RB1(139), RBL1(21), SKP2(3), SMAD4(191), TBC1D8(11), TFDP1(10), TGFB1(2), WEE1(15) 73522047 1336 334 1046 477 242 428 134 298 214 20 0.494 1.000 1.000 126 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(13), AKT1(11), AKT2(8), AKT3(8), APAF1(27), ATM(237), BAD(1), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CAPN1(2), CAPN2(10), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CSF2RB(13), CYCS(1), DFFA(6), DFFB(2), ENDOG(3), FADD(1), FAS(9), FASLG(3), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL3(6), IRAK1(6), IRAK2(11), IRAK3(11), IRAK4(8), MAP3K14(6), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), NTRK1(17), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), RIPK1(7), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFRSF1A(4), TNFSF10(3), TRAF2(8) 55594231 1197 333 874 427 207 398 161 246 174 11 0.401 1.000 1.000 127 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 118 ALCAM(12), CADM1(18), CADM3(15), CD2(7), CD22(17), CD226(6), CD274(5), CD276(6), CD28(5), CD34(7), CD4(4), CD40(7), CD40LG(10), CD6(6), CD80(6), CD86(2), CD8A(2), CD8B(4), CDH15(3), CDH2(40), CDH3(9), CDH4(24), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CNTN1(31), CNTN2(13), CNTNAP1(15), CNTNAP2(39), CTLA4(5), ESAM(6), F11R(4), GLG1(15), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), ICAM1(4), ICAM2(6), ICAM3(3), ICOS(2), ICOSLG(5), ITGA4(20), ITGA6(16), ITGA8(20), ITGA9(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGB1(13), ITGB2(18), ITGB7(10), ITGB8(12), JAM2(2), JAM3(9), L1CAM(17), MAG(11), MPZ(2), MPZL1(7), NCAM1(18), NCAM2(29), NEGR1(4), NEO1(14), NFASC(41), NLGN1(21), NLGN2(5), NLGN3(11), NRCAM(21), NRXN1(46), NRXN2(24), NRXN3(35), OCLN(2), PDCD1(2), PDCD1LG2(2), PTPRC(36), PTPRF(23), PTPRM(48), PVR(2), PVRL1(9), PVRL2(5), PVRL3(5), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SELE(13), SELL(5), SELP(15), SIGLEC1(19), SPN(6), VCAM1(15), VCAN(74) 92717775 1317 332 1242 511 403 192 158 351 208 5 0.742 1.000 1.000 128 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGAP1(3), ARHGAP4(7), ARHGEF11(24), BTK(12), CDC42(3), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(16), ITPR1(43), ITPR2(49), ITPR3(44), LIMK1(8), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3CG(41), PIK3R1(62), PITX2(2), PPP1R13B(10), PTEN(333), RACGAP1(5), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), SAG(5), WASF1(6), WASL(18) 46398755 1297 332 941 475 196 475 195 253 163 15 0.488 1.000 1.000 129 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 94 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), CREB3(6), CREB3L1(6), CREB3L2(5), CREB3L3(7), CREB3L4(5), CREBBP(81), CTNNB1(120), DCT(22), DVL2(12), DVL3(10), EDN1(3), EDNRB(19), EP300(56), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAS(39), GSK3B(17), HRAS(4), KIT(161), KITLG(3), LEF1(9), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MC1R(2), MITF(19), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), POMC(4), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAF1(16), TCF7(15), TCF7L1(8), TYR(12), TYRP1(6), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4) 68254110 1271 330 1085 499 396 335 154 242 144 0 0.656 1.000 1.000 130 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 94 AKT1(11), AKT2(8), AKT3(8), CASP8(20), CCL4(1), CD14(6), CD40(7), CD80(6), CD86(2), CHUK(27), CXCL10(2), CXCL11(4), CXCL9(7), FADD(1), FOS(5), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IKBKB(9), IKBKE(9), IKBKG(2), IL12A(2), IL12B(1), IL1B(5), IL6(7), IL8(6), IRAK1(6), IRAK4(8), IRF3(4), IRF5(6), JUN(2), LBP(8), LY96(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K7(9), MAP3K8(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), RAC1(2), RELA(10), RIPK1(7), SPP1(4), STAT1(17), TBK1(12), TICAM1(15), TIRAP(5), TLR1(11), TLR2(12), TLR3(15), TLR4(18), TLR5(9), TLR6(14), TLR7(18), TLR8(20), TLR9(16), TNF(2), TOLLIP(5), TRAF3(12), TRAF6(4) 58482313 1105 326 864 365 209 326 161 254 151 4 0.0664 1.000 1.000 131 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(11), AKT2(8), AKT3(8), BRD4(22), CAP1(5), CBL(45), CDC42(3), CDKN2A(9), F2RL2(8), FLOT1(7), FLOT2(2), GRB2(11), GSK3A(6), GSK3B(17), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), LNPEP(23), MAPK1(3), MAPK3(4), PARD3(13), PARD6A(2), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PPYR1(8), PTEN(333), PTPN1(11), RAF1(16), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SERPINB6(4), SFN(1), SHC1(14), SLC2A4(8), SORBS1(15), SOS1(16), SOS2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 38664488 1226 323 847 419 188 489 185 220 133 11 0.0188 1.000 1.000 132 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(11), AKT2(8), AKT3(8), BCL10(8), BLNK(2), BTK(12), CARD11(59), CD19(10), CD22(17), CD72(4), CD79A(6), CD79B(3), CHUK(27), CR2(22), FCGR2B(2), FOS(5), GSK3B(17), HRAS(4), IFITM1(2), IKBKB(9), IKBKG(2), INPP5D(10), JUN(2), LILRB3(8), LYN(13), MALT1(13), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RASGRP3(9), SYK(8), VAV1(24), VAV2(20), VAV3(30) 48246786 992 322 738 332 216 318 155 185 116 2 0.0181 1.000 1.000 133 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 69 AKT1(11), AKT2(8), AKT3(8), BTK(12), FCER1A(6), FYN(17), GAB2(10), GRB2(11), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(10), LAT(3), LCP2(10), LYN(13), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MS4A2(6), PDK1(7), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PRKCA(8), PRKCD(15), PRKCE(6), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SOS1(16), SOS2(17), SYK(8), TNF(2), VAV1(24), VAV2(20), VAV3(30) 46461930 987 321 738 331 206 328 155 194 102 2 0.0387 1.000 1.000 134 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(4), IMPA2(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(16), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), MINPP1(6), MIOX(3), OCRL(21), PI4KA(29), PI4KB(5), PIK3C3(29), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15) 48729399 1216 320 869 449 214 455 181 235 122 9 0.492 1.000 1.000 135 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(14), CRKL(5), DOCK1(24), ELK1(4), FOS(5), GAB1(15), GRB2(11), HGF(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAP4K1(7), MAPK1(3), MAPK3(4), MAPK8(17), MET(55), PAK1(11), PIK3CA(344), PIK3R1(62), PTEN(333), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAF1(16), RAP1A(2), RAP1B(2), RASA1(24), SOS1(16), SRC(3), STAT3(10) 30595431 1130 320 753 426 122 510 171 211 106 10 0.278 1.000 1.000 136 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(11), AKT2(8), AKT3(8), BCR(12), BTK(12), CD19(10), CDKN2A(9), DAPP1(3), FLOT1(7), FLOT2(2), GAB1(15), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), PDK1(7), PHF11(3), PIK3CA(344), PITX2(2), PLCG2(28), PPP1R13B(10), PREX1(27), PTEN(333), PTPRC(36), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SAG(5), SYK(8), TEC(10), VAV1(24) 36676407 1142 320 826 418 183 445 187 209 109 9 0.367 1.000 1.000 137 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 AKT1(11), ASAH1(4), ATF1(6), BRAF(125), CAMP(1), CREB1(3), CREB3(6), CREB5(8), CREBBP(81), CRKL(5), DAG1(10), EGR1(14), EGR2(16), EGR3(6), EGR4(3), ELK1(4), FRS2(6), GNAQ(11), JUN(2), MAP1B(51), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NTRK1(17), OPN1LW(4), PIK3C2G(21), PIK3CA(344), PIK3CD(11), PIK3R1(62), PTPN11(41), RPS6KA3(16), SHC1(14), SRC(3), TERF2IP(4) 31681697 983 320 661 380 140 345 149 226 118 5 0.654 1.000 1.000 138 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT1(11), AKT2(8), AKT3(8), BAD(1), CASP9(6), CDC42(3), HRAS(4), KDR(42), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPKAPK2(5), MAPKAPK3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NOS3(23), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCA(8), PRKCG(24), PTGS2(10), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SH2D2A(5), SHC2(2), SPHK1(3), SPHK2(5), SRC(3), VEGFA(5) 45329791 909 319 662 341 215 281 144 157 110 2 0.414 1.000 1.000 139 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 90 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ATF4(4), CACNA1C(35), CACNA1D(29), CACNA1F(37), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDC42(3), CGA(3), EGFR(115), ELK1(4), FSHB(6), GNA11(8), GNAQ(11), GNAS(39), GNRH1(4), GNRH2(6), GNRHR(9), GRB2(11), HBEGF(1), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), LHB(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK9(13), MMP14(7), MMP2(18), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLD1(19), PLD2(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCD(15), PRKX(3), PTK2B(13), RAF1(16), SOS1(16), SOS2(17), SRC(3) 83919477 1208 318 1112 416 386 245 147 267 160 3 0.103 1.000 1.000 140 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(27), ADCY8(34), ARAF(10), ATF4(4), BRAF(125), CACNA1C(35), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CREBBP(81), EP300(56), GNAQ(11), GRIA1(38), GRIA2(29), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R1A(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF3(8), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18) 66384440 1114 316 971 429 335 260 120 262 134 3 0.707 1.000 1.000 141 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 78 ACVR1(9), ACVR1C(11), ACVR2B(14), ACVRL1(8), AMHR2(4), BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BMPR1B(15), CHRD(16), COMP(6), CREBBP(81), CUL1(17), DCN(9), E2F4(2), E2F5(6), EP300(56), FST(5), GDF5(13), GDF6(7), ID1(2), ID4(1), IFNG(3), INHBA(21), INHBB(3), INHBC(4), INHBE(3), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(3), MAPK3(4), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), RBL1(21), RBL2(24), RBX1(1), ROCK1(35), ROCK2(20), RPS6KB1(9), RPS6KB2(6), SKP1(2), SMAD1(10), SMAD4(191), SMAD5(4), SMAD7(2), SMAD9(7), SMURF1(9), SMURF2(7), SP1(7), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNF(2), ZFYVE16(23), ZFYVE9(23) 61182620 1001 315 862 370 293 212 116 219 153 8 0.595 1.000 1.000 142 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(14), CREBBP(81), DUSP1(7), EHHADH(15), EP300(56), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(4), ME1(14), MRPL11(1), MYC(5), NCOA1(15), NCOR1(35), NCOR2(44), NFKBIA(1), NR1H3(16), NR2F1(6), NRIP1(18), PDGFA(2), PIK3CA(344), PIK3R1(62), PPARA(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PTGS2(10), RB1(139), RELA(10), RXRA(8), SP1(7), SRA1(3), STAT5A(10), STAT5B(20), TNF(2) 42050973 1048 315 723 365 177 368 139 188 166 10 0.145 1.000 1.000 143 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(10), BRAF(125), C7orf16(11), CACNA1A(28), CRHR1(6), GNA11(8), GNA12(7), GNA13(3), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAS(39), GNAZ(5), GRIA1(38), GRIA2(29), GRIA3(15), GRID2(28), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), IGF1(6), IGF1R(22), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NOS1(31), NOS3(23), NPR1(18), NPR2(17), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), RAF1(16), RYR1(70) 73137813 1191 309 1043 440 388 217 137 299 147 3 0.624 1.000 1.000 144 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADK(7), ADSL(13), ADSS(8), ADSSL1(6), AK1(2), AK5(10), AK7(8), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), FHIT(1), GART(5), GDA(7), GMPR(9), GMPR2(3), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NPR1(18), NPR2(17), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE10A(19), PDE11A(16), PDE1A(10), PDE1C(19), PDE2A(10), PDE3B(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6D(2), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PPAT(8), PRIM1(5), PRIM2(3), PRPS1(9), PRPS1L1(4), PRPS2(6), PRUNE(4), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), XDH(19) 111775779 1263 308 1199 426 370 195 195 303 199 1 0.0996 1.000 1.000 145 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(27), ATM(237), ATR(53), BAI1(13), BAX(16), BID(2), CASP3(4), CASP8(20), CASP9(6), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG1(5), CCNG2(4), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN2A(9), CHEK1(11), CHEK2(30), CYCS(1), DDB2(1), EI24(1), FAS(9), GADD45G(1), GTSE1(5), IGF1(6), IGFBP3(8), MDM2(11), MDM4(7), PPM1D(6), PTEN(333), RCHY1(4), RFWD2(6), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(7), SERPINE1(10), SESN1(5), SESN2(9), SESN3(8), SFN(1), SIAH1(2), STEAP3(6), THBS1(14), TNFRSF10B(8), TP53I3(2), TP73(5), TSC2(17), ZMAT3(12) 41608628 1019 308 762 389 131 378 114 211 165 20 0.848 1.000 1.000 146 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(11), AKT2(8), AKT3(8), BRAF(125), CAB39(2), EIF4B(5), FIGF(6), HIF1A(16), IGF1(6), MAPK1(3), MAPK3(4), PDPK1(4), PGF(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PRKAA1(9), PRKAA2(20), RHEB(5), RICTOR(27), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), STK11(38), TSC1(18), TSC2(17), ULK2(14), ULK3(3), VEGFA(5), VEGFB(3), VEGFC(15) 33606906 941 308 634 332 156 329 141 206 105 4 0.168 1.000 1.000 147 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), BCR(12), BLNK(2), BTK(12), CD19(10), CD22(17), CR2(22), CSK(5), DAG1(10), FLOT1(7), FLOT2(2), GRB2(11), GSK3A(6), GSK3B(17), INPP5D(10), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP4K1(7), MAPK1(3), MAPK3(4), NFATC2(12), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLCG2(28), PPP1R13B(10), PPP3CA(5), PPP3CB(11), PPP3CC(7), PTPRC(36), RAF1(16), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24) 47589464 964 307 731 303 210 307 153 180 110 4 0.00283 1.000 1.000 148 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(11), EIF4A2(12), EIF4G1(19), EIF4G2(16), EIF4G3(19), GHR(12), IRS1(21), MAPK1(3), MAPK14(8), MAPK3(4), MKNK1(4), PABPC1(8), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PRKCA(8), PTEN(333), RPS6KB1(9) 19190355 906 303 563 340 87 419 147 156 87 10 0.259 1.000 1.000 149 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(11), AKT2(8), AKT3(8), BAD(1), BTK(12), CDKN2A(9), DAPP1(3), GRB2(11), GSK3A(6), GSK3B(17), IARS(10), IGFBP1(2), INPP5D(10), PDK1(7), PIK3CA(344), PPP1R13B(10), PTEN(333), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SOS1(16), SOS2(17), TEC(10), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3) 24300500 941 301 619 349 108 419 147 169 89 9 0.188 1.000 1.000 150 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(11), EIF4A2(12), EIF4B(5), EIF4G1(19), EIF4G2(16), EIF4G3(19), FKBP1A(2), MKNK1(4), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9), TSC1(18), TSC2(17) 18382092 890 298 550 336 88 422 136 144 90 10 0.220 1.000 1.000 151 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(11), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), GSK3B(17), IGF1(6), IGF1R(22), INPPL1(16), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9) 13571114 862 296 523 330 77 425 135 135 80 10 0.392 1.000 1.000 152 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(14), AGT(12), AKT1(11), CALM2(1), CALM3(1), CALR(2), CAMK1(9), CAMK1G(7), CAMK4(9), CREBBP(81), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(10), FGF2(5), FKBP1A(2), GATA4(4), GSK3B(17), HAND1(5), HAND2(2), HRAS(4), IGF1(6), LIF(1), MAP2K1(12), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MEF2C(15), MYH2(42), NFATC2(12), NFATC3(15), NFATC4(12), NPPA(1), PIK3CA(344), PIK3R1(62), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAF1(16), RPS6KB1(9), SYT1(14) 32957459 855 296 614 302 171 301 129 155 96 3 0.100 1.000 1.000 153 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(11), BCAR1(6), CDKN1B(6), GRB2(11), ILK(3), ITGB1(13), MAPK1(3), MAPK3(4), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PTEN(333), PTK2(24), SHC1(14), SOS1(16) 12839244 863 293 520 320 63 424 137 141 87 11 0.182 1.000 1.000 154 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 39 CALM2(1), CALM3(1), CD3D(5), CD3E(2), ELK1(4), FOS(5), FYN(17), GRB2(11), HRAS(4), JUN(2), LAT(3), LCK(9), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PIK3CA(344), PIK3R1(62), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), PTPN7(4), RAC1(2), RAF1(16), RASA1(24), RELA(10), SHC1(14), SOS1(16), SYT1(14), VAV1(24), ZAP70(12) 30910758 761 293 515 254 150 280 112 123 93 3 0.0217 1.000 1.000 155 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(11), AKT2(8), AKT3(8), BPNT1(9), GRB2(11), ILK(3), MAPK1(3), MAPK3(4), PDK1(7), PIK3CA(344), PIK3CD(11), PTEN(333), PTK2B(13), RBL2(24), SHC1(14), SOS1(16) 13697746 819 290 497 308 67 393 136 145 69 9 0.421 1.000 1.000 156 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCR(12), BLNK(2), BTK(12), CD19(10), CSK(5), DAG1(10), EPHB2(16), GRB2(11), ITPKA(3), ITPKB(15), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PI3(3), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLCG2(28), PPP1R13B(10), RAF1(16), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24) 34085306 752 290 517 237 155 268 124 133 69 3 0.00297 1.000 1.000 157 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF1(2), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), ELAVL1(5), FLT1(43), FLT4(18), HIF1A(16), HRAS(4), KDR(42), NOS3(23), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTK2(24), PXN(2), SHC1(14), VHL(105) 22291426 783 290 500 293 101 333 128 130 88 3 0.379 1.000 1.000 158 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(2), CHN1(6), LIMK1(8), MAP3K1(21), MYL2(2), MYLK(33), NCF2(10), PAK1(11), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLD1(19), PPP1R12B(33), RAC1(2), RALBP1(8), RPS6KB1(9), TRIO(40), VAV1(24), WASF1(6) 24166713 714 288 475 240 105 267 118 132 86 6 0.0690 1.000 1.000 159 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(12), CALM2(1), CALM3(1), ELK1(4), FCER1A(6), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PAK2(15), PIK3CA(344), PIK3R1(62), PLA2G4A(16), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAF1(16), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24) 27664113 726 287 488 233 125 277 116 124 81 3 0.00652 1.000 1.000 160 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(7), EGF(8), EGFR(115), ELK1(4), FOS(5), GRB2(11), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10) 25493206 776 285 525 267 126 305 124 140 77 4 0.0840 1.000 1.000 161 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), DAG1(10), DGKA(8), ETFA(5), GCA(1), ITGA9(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAPK1(3), MAPK3(4), NR1I3(5), PAK1(11), PDE3A(21), PDE3B(10), PI3(3), PIK3C2G(21), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLDN(1), PSME1(1), RIPK3(6), RPS4X(3), SGCB(7), VASP(4) 31891832 752 285 543 261 135 259 121 147 85 5 0.143 1.000 1.000 162 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 88 ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), AKAP1(7), AKAP10(6), AKAP11(30), AKAP12(36), AKAP2(2), AKAP3(26), AKAP4(16), AKAP5(6), AKAP6(44), AKAP7(21), AKAP8(8), AKAP9(75), ARHGEF1(15), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(7), GNA13(3), GNA14(13), GNA15(6), GNAI2(2), GNAI3(2), GNAL(5), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), HRAS(4), IL18BP(4), ITPR1(43), KCNJ3(11), PALM2(1), PDE1A(10), PDE1B(11), PDE1C(19), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PLCB3(15), PPP3CA(5), PPP3CC(7), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKD3(19), RRAS(2), SLC9A1(12), USP5(10) 77959550 1022 284 941 366 306 181 118 226 188 3 0.352 1.000 1.000 163 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MIOX(3), OCRL(21), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CA(344), PIK3CB(6), PIK3CG(41), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28) 29752016 694 283 480 246 134 240 123 134 62 1 0.281 1.000 1.000 164 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(11), AKT3(8), BCAR1(6), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(10), CAPN3(11), CAPN5(14), CAPN6(15), CAPN7(12), CAPN9(5), CAPNS1(4), CAV1(1), CAV2(4), CAV3(4), CDC42(3), CSK(5), DOCK1(24), FYN(17), GIT2(11), GRB2(11), ILK(3), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK10(18), MAPK12(4), MAPK4(4), MAPK6(19), MAPK7(6), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(19), RHO(5), ROCK1(35), ROCK2(20), SDCCAG8(4), SEPP1(4), SHC1(14), SHC3(5), SORBS1(15), SOS1(16), SRC(3), TLN1(23), TNS1(39), VASP(4), VAV2(20), VAV3(30), VCL(10), ZYX(5) 89351139 1051 282 983 387 302 160 113 280 187 9 0.780 1.000 1.000 165 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(27), AKT1(11), BAD(1), BAX(16), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(22), IL3(6), KIT(161), KITLG(3), PIK3CA(344), PIK3R1(62), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), YWHAH(5) 14365102 715 281 450 264 101 333 109 104 65 3 0.360 1.000 1.000 166 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(27), AKT1(11), ASAH1(4), GNAI1(5), GNB1(3), GNGT1(1), ITGAV(21), ITGB3(16), MAPK1(3), MAPK3(4), PDGFA(2), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLCB1(23), PRKCA(8), PTK2(24), RAC1(2), SMPD1(10), SMPD2(3), SPHK1(3), SRC(3) 18830928 643 280 415 236 90 262 111 118 56 6 0.230 1.000 1.000 167 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(64), ASH2L(7), C17orf79(1), CARM1(3), CTCFL(19), DOT1L(10), EED(2), EHMT1(11), EHMT2(10), EZH1(9), EZH2(51), FBXO11(15), HCFC1(13), HSF4(5), JMJD4(2), JMJD6(9), KDM6A(27), MEN1(32), MLL(58), MLL2(67), MLL3(88), MLL4(41), MLL5(32), NSD1(29), OGT(10), PAXIP1(22), PPP1CA(2), PPP1CB(6), PPP1CC(2), PRDM2(36), PRDM7(6), PRDM9(43), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), RBBP5(4), SATB1(17), SETD1A(21), SETD2(55), SETD7(9), SETD8(6), SETDB1(19), SETDB2(6), SETMAR(4), SMYD3(6), STK38(11), SUV39H1(4), SUV39H2(7), SUV420H1(17), SUV420H2(1), SUZ12(5), WHSC1(28), WHSC1L1(10) 78519652 994 279 871 309 259 220 89 224 190 12 0.177 1.000 1.000 168 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(27), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), GNAS(39), GRB2(11), HRAS(4), MAPK1(3), MAPK14(8), MAPK3(4), PIK3CA(344), PIK3R1(62), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAC1(2), RPS6KA1(9), RPS6KA5(13), SOS1(16) 19542475 626 279 394 212 113 257 101 101 52 2 0.0502 1.000 1.000 169 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(11), CREB1(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NFKB1(11), PIK3CA(344), PIK3R1(62), RB1(139), RELA(10), SP1(7) 13584114 654 278 395 223 83 282 103 114 62 10 0.0245 1.000 1.000 170 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 27 AKT1(11), CABIN1(24), CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), HDAC5(14), IGF1(6), IGF1R(22), INSR(21), MAP2K6(5), MAPK14(8), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NFATC2(12), PIK3CA(344), PIK3R1(62), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYT1(14), YWHAH(5) 21577268 620 278 404 236 102 249 104 105 58 2 0.440 1.000 1.000 171 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), PDGFA(2), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10) 23650549 719 278 476 236 112 275 113 135 78 6 0.0409 1.000 1.000 172 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), GRB2(11), GSK3A(6), GSK3B(17), IL4R(6), IRS1(21), JAK1(22), JAK3(31), MAP4K1(7), MAPK1(3), MAPK3(4), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PPP1R13B(10), RAF1(16), SHC1(14), SOS1(16), SOS2(17), STAT6(4) 23446042 659 278 420 210 104 262 106 109 74 4 0.0189 1.000 1.000 173 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(237), CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CREB3(6), CREB3L1(6), CREB3L3(7), CREB3L4(5), E2F2(7), E2F3(6), E2F4(2), E2F5(6), E2F6(4), GBA2(15), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MNAT1(4), MYC(5), MYT1(25), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLE(41), POLE2(6), PRIM1(5), RB1(139), RBL1(21), RPA1(12), RPA2(1), RPA3(4), TFDP1(10), TFDP2(5), WEE1(15) 46526449 797 277 654 276 137 242 83 192 127 16 0.281 1.000 1.000 174 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(81), EP300(56), FYN(17), IL2RG(9), IL7(4), IL7R(13), JAK1(22), JAK3(31), LCK(9), NMI(4), PIK3CA(344), PIK3R1(62), PTK2B(13), STAT5A(10), STAT5B(20) 19280876 697 276 444 244 100 280 107 118 89 3 0.212 1.000 1.000 175 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 DIAPH1(7), FYN(17), GSN(4), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PIK3CA(344), PIK3R1(62), PTK2(24), PXN(2), RAF1(16), ROCK1(35), SHC1(14), SRC(3), TLN1(23) 24171661 634 274 400 222 92 236 115 108 75 8 0.135 1.000 1.000 176 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(5), GHR(12), GRB2(11), HRAS(4), INSR(21), IRS1(21), JAK2(55), MAP2K1(12), MAPK1(3), MAPK3(4), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTPN6(4), RAF1(16), RPS6KA1(9), SHC1(14), SLC2A4(8), SOS1(16), SRF(4), STAT5A(10), STAT5B(20) 22334539 682 273 434 251 104 280 115 111 66 6 0.453 1.000 1.000 177 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 107 ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADK(7), ADSL(13), ADSS(8), AK1(2), AK5(10), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), ATP1B1(4), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), FHIT(1), GART(5), GDA(7), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NPR1(18), NPR2(17), NT5C(1), NT5E(7), NT5M(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE1A(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6B(11), PDE6C(12), PDE7B(6), PDE8A(6), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), PPAT(8), PRPS1(9), PRPS1L1(4), PRPS2(6), PRUNE(4), RRM1(3), RRM2(5) 86149002 991 273 940 331 295 153 141 245 156 1 0.190 1.000 1.000 178 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), HRAS(4), MAPK1(3), MAPK3(4), NFKB1(11), NFKBIA(1), PAK1(11), PIK3CA(344), PIK3R1(62), RAC1(2), RAF1(16), RB1(139), RELA(10), TFDP1(10) 13838106 656 272 392 235 85 285 105 105 66 10 0.120 1.000 1.000 179 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 77 ANPEP(19), CD14(6), CD19(10), CD1A(6), CD1B(6), CD1C(5), CD1D(6), CD2(7), CD22(17), CD33(3), CD34(7), CD36(3), CD37(4), CD38(5), CD3D(5), CD3E(2), CD4(4), CD44(6), CD5(9), CD55(8), CD7(6), CD8A(2), CD8B(4), CD9(3), CR1(20), CR2(22), CSF1(5), CSF1R(16), CSF3(3), CSF3R(19), DNTT(13), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(36), FLT3LG(1), GP5(9), GP9(1), GYPA(8), HLA-DRB1(7), HLA-DRB5(4), IL11(6), IL11RA(4), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL2RA(6), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL7(4), IL7R(13), ITGA1(12), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGAM(14), ITGB3(16), KIT(161), KITLG(3), MME(27), MS4A1(7), TFRC(7), THPO(6), TNF(2), TPO(36) 53533448 806 271 716 291 205 203 105 197 92 4 0.207 1.000 1.000 180 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CBL(45), CFLAR(3), CRKL(5), FOS(5), GRB2(11), HRAS(4), IL2RA(6), IL2RB(5), IL2RG(9), IRS1(21), JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), MYC(5), NMI(4), PIK3CA(344), PIK3R1(62), PPIA(1), PTPN6(4), RAF1(16), RPS6KB1(9), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8) 23628185 702 271 450 228 103 267 123 113 92 4 0.0505 1.000 1.000 181 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(27), ARHGEF1(15), F2(10), F2R(11), GNA12(7), GNA13(3), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), MAP3K7(9), PIK3CA(344), PIK3R1(62), PLCB1(23), PPP1R12B(33), PRKCA(8), PTK2B(13), ROCK1(35) 17531648 620 271 380 218 92 243 92 105 82 6 0.357 1.000 1.000 182 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(11), AKT2(8), AKT3(8), CISH(2), GRB2(11), IARS(10), IL13RA1(6), IL2RG(9), IL4(5), IL4R(6), INPP5D(10), JAK1(22), JAK2(55), JAK3(31), PI3(3), PIK3CA(344), PPP1R13B(10), RPS6KB1(9), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT6(4), TYK2(5) 24712123 629 271 407 219 87 256 106 114 61 5 0.162 1.000 1.000 183 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(31), CDKN2A(9), MDM2(11), MYC(5), PIK3CA(344), PIK3R1(62), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), RAC1(2), RB1(139), TWIST1(3) 12645933 648 270 391 228 80 291 106 102 59 10 0.0427 1.000 1.000 184 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IGF1(6), IGF1R(22), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PTPN11(41), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4) 16583740 636 270 392 212 92 263 106 108 64 3 0.0242 1.000 1.000 185 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), INSR(21), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PTPN11(41), RAF1(16), RASA1(24), SHC1(14), SLC2A4(8), SOS1(16), SRF(4) 17063492 637 269 394 214 91 263 109 110 61 3 0.0255 1.000 1.000 186 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 29 DUSP1(7), GORASP1(13), IKBKG(2), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK5(7), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CA(344), PIK3CD(11), PIK3R1(62), SYT1(14), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4) 18919431 616 269 391 209 96 252 102 104 60 2 0.0748 1.000 1.000 187 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAPK3(4), MPL(9), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), THPO(6) 20895475 675 269 426 226 95 280 106 111 77 6 0.108 1.000 1.000 188 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(44), ABCA10(36), ABCA12(82), ABCA13(72), ABCA3(24), ABCA4(35), ABCA5(36), ABCA6(35), ABCA7(22), ABCA8(32), ABCA9(39), ABCB1(35), ABCB10(11), ABCB11(19), ABCB4(28), ABCB5(29), ABCB6(8), ABCB7(7), ABCB8(10), ABCB9(7), ABCC1(25), ABCC10(20), ABCC11(17), ABCC12(27), ABCC2(23), ABCC3(11), ABCC4(24), ABCC5(22), ABCC6(13), ABCC8(25), ABCC9(26), ABCD1(5), ABCD2(21), ABCD3(5), ABCD4(10), ABCG1(8), ABCG2(17), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(21), TAP1(9), TAP2(16) 76282590 984 268 966 304 255 148 112 294 164 11 0.0126 1.000 1.000 189 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 80 ATF2(7), BRAF(125), CHUK(27), CREB1(3), DAXX(18), ELK1(4), FOS(5), GRB2(11), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP3K9(11), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAP4K5(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK4(4), MAPK6(19), MAPK7(6), MAPK8(17), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MKNK2(7), MYC(5), NFKB1(11), NFKBIA(1), PAK1(11), PAK2(15), RAC1(2), RAF1(16), RELA(10), RIPK1(7), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KB1(9), RPS6KB2(6), SHC1(14), SP1(7), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8) 62003430 920 268 768 267 223 204 118 227 146 2 0.00565 1.000 1.000 190 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CXCL12(2), CXCR4(7), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), NFKB1(11), PIK3C2G(21), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTK2(24), PTK2B(13), PXN(2), RAF1(16), RELA(10) 18229328 588 266 372 221 87 241 104 97 56 3 0.407 1.000 1.000 191 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 25 BRAF(125), CPEB1(10), EGFR(115), ERBB2(37), ERBB4(65), ETS1(10), ETS2(5), ETV6(11), ETV7(3), GRB2(11), MAP2K1(12), MAPK1(3), MAPK3(4), NOTCH2(35), NOTCH3(31), NOTCH4(20), PIWIL1(31), PIWIL2(16), PIWIL3(15), PIWIL4(10), RAF1(16), SOS1(16), SOS2(17), SPIRE1(6), SPIRE2(9) 30095442 633 266 502 202 138 173 84 175 63 0 0.0626 1.000 1.000 192 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(11), BCL2(2), BCR(12), CRKL(5), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAP3K1(21), MAPK3(4), MAPK8(17), MYC(5), PIK3CA(344), PIK3R1(62), RAF1(16), SOS1(16), STAT1(17), STAT5A(10), STAT5B(20) 18046223 651 265 414 213 94 276 109 108 59 5 0.0147 1.000 1.000 193 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(11), BAD(1), BCL2L1(1), CASP9(6), CDC42(3), CHUK(27), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(12), MAPK3(4), NFKB1(11), PIK3CA(344), PIK3R1(62), RAC1(2), RAF1(16), RALA(8), RALBP1(8), RALGDS(9), RELA(10) 12582595 544 262 323 179 86 229 101 80 46 2 0.0116 1.000 1.000 194 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 87 ACTB(4), BAD(1), BCL2(2), CABIN1(24), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(9), CD3E(2), CD69(4), CDKN1A(2), CNR1(13), CREBBP(81), CSNK2A1(7), CSNK2B(2), CTLA4(5), EGR2(16), EGR3(6), EP300(56), FCER1A(6), FCGR3A(5), FOS(5), FOSL1(1), GATA3(17), GATA4(4), GRLF1(19), GSK3A(6), GSK3B(17), HRAS(4), ICOS(2), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL13(2), IL1B(5), IL2(5), IL2RA(6), IL3(6), IL4(5), IL6(7), IL8(6), ITK(26), KPNA5(12), MAPK14(8), MAPK8(17), MAPK9(13), MEF2A(7), MEF2D(3), MYF5(7), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB2(6), NFKBIB(5), NFKBIE(5), NPPB(5), NUP214(22), OPRD1(6), P2RX7(13), PAK1(11), PIN1(2), PPIA(1), PPP3CB(11), PPP3CC(7), PPP3R1(4), PTPRC(36), RELA(10), RPL13A(1), SFN(1), SLA(8), SP1(7), SP3(13), TGFB1(2), TNF(2), TRAF2(8), TRPV6(20), VAV1(24), VAV2(20), VAV3(30), XPO5(8) 58290451 818 261 751 286 246 199 88 172 113 0 0.148 1.000 1.000 195 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(11), BAD(1), GRB2(11), HRAS(4), IGF1R(22), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), PIK3CA(344), PIK3R1(62), RAF1(16), SHC1(14), SOS1(16), YWHAH(5) 12595172 546 261 318 176 74 233 101 82 53 3 0.0166 1.000 1.000 196 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(8), ADAM17(13), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), CASP3(4), CDC42(3), CHUK(27), CSK(5), CXCL1(1), EGFR(115), F11R(4), GIT1(4), HBEGF(1), IGSF5(16), IKBKB(9), IKBKG(2), IL8(6), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP3K14(6), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK8(17), MAPK9(13), MET(55), NFKB1(11), NFKB2(6), NFKBIA(1), NOD1(10), PAK1(11), PLCG1(19), PLCG2(28), PTPN11(41), PTPRZ1(43), RAC1(2), RELA(10), SRC(3), TCIRG1(7), TJP1(25) 47655324 716 260 621 241 163 224 89 155 84 1 0.113 1.000 1.000 197 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(45), CD28(5), CD3D(5), CSK(5), CTLA4(5), DAG1(10), DTYMK(1), EPHB2(16), FBXW7(156), GRAP2(7), GRB2(11), ITK(26), ITPKA(3), ITPKB(15), LAT(3), LCK(9), LCP2(10), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLCG1(19), PTPRC(36), RAF1(16), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), SOS1(16), SOS2(17), VAV1(24), ZAP70(12) 36408350 624 260 522 207 166 151 69 133 104 1 0.139 1.000 1.000 198 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), AKT1(11), ANXA1(4), CALM2(1), CALM3(1), GNAS(39), GNB1(3), GNGT1(1), NFKB1(11), NOS3(23), NPPA(1), NR3C1(11), PIK3CA(344), PIK3R1(62), RELA(10), SYT1(14) 11393777 539 258 304 187 83 236 91 79 48 2 0.111 1.000 1.000 199 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(11), DPM2(1), GRB2(11), HRAS(4), KLK2(4), NTRK1(17), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), SHC1(14), SOS1(16) 10659201 511 258 291 186 50 231 98 80 49 3 0.298 1.000 1.000 200 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 IL18(3), ITGB1(13), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LAT(3), MAP2K1(12), MAPK3(4), PAK1(11), PIK3CA(344), PIK3R1(62), PTK2B(13), PTPN6(4), RAC1(2), SYK(8), VAV1(24) 12437604 522 257 315 183 64 228 92 91 45 2 0.170 1.000 1.000 201 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(11), PIK3CA(344), PIK3R1(62), PLCB1(23), PLCG1(19), PRKCA(8), VAV1(24) 9053724 491 257 282 182 60 224 92 77 36 2 0.411 1.000 1.000 202 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(11), CREB1(3), GRB2(11), HRAS(4), MAPK1(3), MAPK3(4), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NTRK1(17), PIK3CA(344), PIK3R1(62), PLCG1(19), RPS6KA1(9), SHC1(14) 12775174 532 256 318 194 65 236 98 79 51 3 0.384 1.000 1.000 203 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BTRC(11), CSNK1A1(3), CSNK1A1L(9), CSNK1D(15), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(7), DHH(4), FBXW11(13), GLI1(22), GLI2(28), GLI3(44), GSK3B(17), HHIP(16), IHH(5), LRP2(130), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), PTCH1(143), PTCH2(21), RAB23(4), SHH(3), SMO(13), STK36(20), SUFU(5), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4) 38049670 715 256 617 261 227 157 82 139 107 3 0.464 1.000 1.000 204 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), DPM2(1), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), KLK2(4), MAP2K1(12), MAPK3(4), MAPK8(17), NGFR(5), PIK3CA(344), PIK3R1(62), PLCG1(19), RAF1(16), SHC1(14), SOS1(16) 12844340 547 256 324 185 72 237 97 87 51 3 0.0671 1.000 1.000 205 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD28(5), CD3D(5), CD3E(2), CD80(6), CD86(2), CTLA4(5), GRB2(11), HLA-DRB1(7), ICOS(2), IL2(5), ITK(26), LCK(9), PIK3CA(344), PIK3R1(62), PTPN11(41) 8282133 532 254 300 185 53 252 93 88 42 4 0.0816 1.000 1.000 206 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 82 AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHX58(6), ENPP1(17), ENPP3(12), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), G6PC(5), G6PC2(3), GAA(14), GANC(9), GBA(4), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), IFIH1(22), LYZL1(4), MGAM(26), MOV10L1(23), NUDT5(1), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SI(28), SKIV2L2(13), SMARCA2(22), SMARCA5(18), TREH(6), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UXS1(9) 85635782 923 252 856 275 257 158 110 220 175 3 0.0469 1.000 1.000 207 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 103 A4GNT(7), ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG6(5), ALG8(13), ALG9(8), B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT5(5), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(10), CHST11(6), CHST12(6), CHST14(1), CHST2(13), CHST3(7), CHST4(8), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(14), EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), FUT11(3), FUT8(11), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GANAB(13), GCNT1(9), GCNT3(6), GCNT4(14), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), NDST1(10), NDST2(10), NDST3(19), NDST4(13), OGT(10), RPN1(4), RPN2(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(6), STT3B(11), UST(12), XYLT1(14), XYLT2(15) 71361348 863 252 803 320 283 148 92 200 140 0 0.922 1.000 1.000 208 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(11), CAT(8), GH1(5), GHR(12), HRAS(4), IGF1(6), IGF1R(22), PIK3CA(344), PIK3R1(62), SHC1(14), SOD2(4) 8888486 492 252 278 179 59 215 93 78 44 3 0.253 1.000 1.000 209 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(11), BAD(1), CHRNB1(10), CHRNG(8), MUSK(15), PIK3CA(344), PIK3R1(62), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(10), YWHAH(5) 10689274 511 251 303 186 62 225 95 78 49 2 0.370 1.000 1.000 210 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(11), BAD(1), CASP9(6), CHUK(27), GH1(5), GHR(12), NFKB1(11), NFKBIA(1), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), RELA(10), YWHAH(5) 9817337 502 251 288 175 63 223 93 80 41 2 0.0467 1.000 1.000 211 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), PAK1(11), PDGFRA(64), PIK3CA(344), PIK3R1(62), RAC1(2), WASL(18) 9475375 533 250 318 186 55 233 97 98 46 4 0.0525 1.000 1.000 212 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(11), AKT2(8), AKT3(8), CDKN1A(2), ELK1(4), GRB2(11), HRAS(4), MAP2K1(12), MAP2K2(3), NGFR(5), NTRK1(17), PIK3CA(344), PIK3CD(11), SHC1(14), SOS1(16) 10438025 470 250 276 177 59 198 99 82 31 1 0.387 1.000 1.000 213 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 68 A2M(25), BDKRB1(4), BDKRB2(6), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(17), C2(10), C3(25), C3AR1(12), C4A(3), C4B(2), C4BPA(12), C4BPB(1), C5(25), C5AR1(8), C6(27), C7(11), C8A(14), C8B(23), C8G(1), C9(12), CD46(4), CD55(8), CFB(7), CFH(32), CFI(9), CPB2(11), CR1(20), CR2(22), F10(5), F11(8), F12(5), F13A1(15), F13B(12), F2(10), F2R(11), F3(2), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), KNG1(9), MASP1(23), MASP2(10), MBL2(3), PLAT(11), PLAU(7), PLAUR(9), PLG(27), PROC(3), PROS1(12), SERPINA1(9), SERPINA5(9), SERPINC1(8), SERPIND1(6), SERPINE1(10), SERPINF2(4), SERPING1(7), TFPI(9), THBD(3), VWF(36) 63684208 814 246 775 288 205 132 116 217 140 4 0.598 1.000 1.000 214 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(40), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ADIPOR1(2), ADIPOR2(6), AKT1(11), AKT2(8), AKT3(8), CAMKK1(2), CAMKK2(9), CD36(3), CHUK(27), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), G6PC(5), G6PC2(3), IKBKB(9), IKBKG(2), IRS1(21), IRS4(36), JAK1(22), JAK2(55), JAK3(31), LEP(1), LEPR(21), MAPK10(18), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NPY(6), PCK1(6), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(16), PTPN11(41), RELA(10), RXRA(8), RXRB(8), RXRG(11), SLC2A1(7), SLC2A4(8), STAT3(10), STK11(38), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5) 54515479 783 246 681 252 211 202 99 169 98 4 0.0323 1.000 1.000 215 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(11), AKT2(8), AKT3(8), ASAH1(4), BRAF(125), DAG1(10), DRD2(9), EGFR(115), EPHB2(16), GRB2(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PI3(3), PIK3CB(6), PITX2(2), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), RAF1(16), RGS20(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT3(10), TERF2IP(4) 38975867 677 246 555 229 163 176 80 180 76 2 0.253 1.000 1.000 216 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(237), ATR(53), BRCA1(32), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(11), CHEK2(30), EP300(56), MDM2(11), MYT1(25), PRKDC(85), RPS6KA1(9), WEE1(15), YWHAH(5), YWHAQ(1) 28157126 611 245 476 235 102 201 56 133 107 12 0.837 1.000 1.000 217 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(237), ATR(53), BRCA1(32), BRCA2(99), CHEK1(11), CHEK2(30), FANCA(12), FANCC(8), FANCD2(42), FANCE(4), FANCF(4), FANCG(7), HUS1(8), MRE11A(20), RAD1(2), RAD17(9), RAD50(30), RAD9A(1), TREX1(3) 30709853 612 242 451 232 71 196 48 146 139 12 0.960 1.000 1.000 218 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(237), BMPR1B(15), CCND2(3), CDK4(4), CDKN1B(6), DAZL(3), DMC1(7), EGR1(14), ESR2(8), FSHR(19), GJA4(3), INHA(6), LHCGR(27), MLH1(68), MSH5(8), NCOR1(35), NR5A1(5), NRIP1(18), PGR(16), PRLR(10), PTGER2(2), SMPD1(10), VDR(4), ZP2(16) 23733670 544 239 433 183 101 164 49 121 101 8 0.321 1.000 1.000 219 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(31), ATM(237), ATR(53), CCNA1(18), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), DHFR(1), GSK3B(17), HDAC1(5), RB1(139), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2) 20217609 576 238 441 222 95 203 42 116 101 19 0.744 1.000 1.000 220 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 53 ALG2(8), BAK1(2), BAX(16), BFAR(9), BTK(12), CAD(23), CASP10(7), CASP3(4), CASP8(20), CASP8AP2(30), CD7(6), CSNK1A1(3), DAXX(18), DEDD(3), DEDD2(1), DFFA(6), DIABLO(3), EGFR(115), EPHB2(16), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(6), MAP3K1(21), MAP3K5(16), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MET(55), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PFN2(4), PTPN13(23), RALBP1(8), RIPK1(7), ROCK1(35), SMPD1(10), TPX2(10), TRAF2(8), TUFM(6) 44980435 633 237 566 212 130 172 68 160 96 7 0.361 1.000 1.000 221 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 ACTG1(6), APAF1(27), ARHGDIB(5), BAG4(10), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), GSN(4), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK8(17), MDM2(11), NFKB1(11), NFKBIA(1), NUMA1(26), PAK2(15), PRKCD(15), PRKDC(85), PSEN1(4), PSEN2(6), PTK2(24), RASA1(24), RB1(139), RELA(10), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8) 45065804 692 236 577 224 148 194 58 152 130 10 0.298 1.000 1.000 222 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 49 ADORA3(15), ALG6(5), CCKBR(16), CCR2(7), CCR3(11), CCR5(11), CELSR1(28), CELSR2(33), CELSR3(28), CHRM2(29), CHRM3(23), CIDEB(1), CXCR3(5), EDNRA(9), EMR2(11), EMR3(19), F2R(11), FSHR(19), GHRHR(2), GNRHR(9), GPR116(21), GPR132(6), GPR133(16), GPR143(4), GPR17(3), GPR18(5), GPR55(2), GPR56(6), GPR61(12), GPR77(4), GPR84(8), GPR88(4), GRM1(37), GRPR(4), HRH4(6), LGR6(9), LPHN2(30), LPHN3(30), NTSR1(5), OR2M4(17), OR8G1(3), OR8G2(9), PTGFR(8), SMO(13), SSTR2(6), TAAR5(10), VN1R1(7) 39268960 577 235 517 208 184 111 54 143 84 1 0.425 1.000 1.000 223 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), BTRC(11), CDC16(6), CDC20(3), CDC23(12), CDC26(1), CDC27(21), CUL1(17), CUL2(15), CUL3(8), FBXW11(13), FBXW7(156), FZR1(4), ITCH(7), RBX1(1), SKP1(2), SKP2(3), SMURF1(9), SMURF2(7), TCEB1(1), TCEB2(1), UBA1(10), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(4), UBE2E2(4), UBE2E3(1), VHL(105), WWP1(21), WWP2(9) 28199328 503 234 385 184 124 129 57 110 80 3 0.494 1.000 1.000 224 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 61 AGTR1(14), AGTR2(17), ATP8A1(16), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CX3CR1(6), CXCR3(5), CXCR4(7), CXCR6(1), EDNRA(9), EDNRB(19), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(4), GRPR(4), LHCGR(27), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), NMBR(4), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), PPYR1(8), SSTR1(12), SSTR2(6), SSTR4(14), TAC4(4), TACR1(9), TACR2(4), TACR3(18), TRHR(9) 32365472 529 226 479 202 181 103 58 135 52 0 0.308 1.000 1.000 225 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CDK2(5), CDK4(4), CHEK1(11), MYT1(25), RB1(139), WEE1(15), YWHAH(5) 11948512 469 225 344 160 74 178 31 102 68 16 0.243 1.000 1.000 226 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(27), ATM(237), BAX(16), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDKN1A(2), MDM2(11), PCNA(5), RB1(139), TIMP3(11) 12170451 467 218 331 171 61 176 31 101 81 17 0.619 1.000 1.000 227 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 40 BCL2(2), CHUK(27), DAXX(18), EGF(8), EGFR(115), ETS1(10), ETS2(5), FOS(5), HOXA7(4), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK1(3), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), NFKB1(11), NFKBIA(1), PPP2CA(3), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), RAF1(16), RELA(10), RIPK1(7), SP1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 32226823 471 216 413 173 130 143 59 94 45 0 0.345 1.000 1.000 228 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(31), ATM(237), BRCA1(32), CDKN1A(2), CHEK1(11), CHEK2(30), JUN(2), MAPK8(17), MDM2(11), MRE11A(20), NFKB1(11), NFKBIA(1), RAD50(30), RBBP8(15), RELA(10), TP73(5) 19727006 465 212 353 202 70 169 33 101 83 9 0.996 1.000 1.000 229 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(115), ELK1(4), GNAS(39), GNB1(3), GNGT1(1), GRB2(11), HRAS(4), IGF1R(22), ITGB1(13), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MYC(5), NGFR(5), PDGFRA(64), PPP2CA(3), PTPRR(16), RAF1(16), RPS6KA1(9), RPS6KA5(13), SHC1(14), SOS1(16), SRC(3), STAT3(10) 22414341 424 210 354 154 111 131 55 83 40 4 0.338 1.000 1.000 230 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 40 ADAM17(13), APH1A(2), CREBBP(81), CTBP1(5), CTBP2(14), DLL1(10), DLL3(7), DLL4(7), DTX1(6), DTX2(10), DTX3(3), DTX3L(11), DTX4(8), DVL2(12), DVL3(10), EP300(56), HDAC1(5), HDAC2(8), HES1(2), JAG1(16), LFNG(6), MAML1(12), MAML2(9), MAML3(4), MFNG(1), NCOR2(44), NCSTN(6), NOTCH2(35), NOTCH3(31), NOTCH4(20), NUMB(10), NUMBL(6), PSEN1(4), PSEN2(6), PSENEN(2), PTCRA(5), RBPJ(21), RBPJL(11), RFNG(1), SNW1(10) 38604140 530 209 467 232 154 101 68 91 115 1 0.987 1.000 1.000 231 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTNNB1(120), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3) 32443702 514 209 431 200 121 122 64 121 82 4 0.783 1.000 1.000 232 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CLDN1(1), CTNNB1(120), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3) 32443702 514 209 431 200 121 122 64 121 82 4 0.783 1.000 1.000 233 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(6), CDC34(2), CDK2(5), CUL1(17), FBXW7(156), RB1(139), TFDP1(10) 5993566 335 206 218 121 72 102 18 70 64 9 0.377 1.000 1.000 234 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(11), APAF1(27), ATM(237), BAD(1), BAX(16), BCL2(2), BCL2L1(1), BID(2), CASP3(4), CASP6(3), CASP7(3), CASP9(6), CYCS(1), EIF2S1(3), PRKCA(8), PTK2(24), PXN(2), STAT1(17), TLN1(23) 18504039 391 205 302 158 61 127 37 85 71 10 0.961 1.000 1.000 235 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(14), AKT1(11), BDKRB2(6), CALM2(1), CALM3(1), CAV1(1), CHRM1(4), CHRNA1(12), FLT1(43), FLT4(18), KDR(42), NOS3(23), PDE2A(10), PDE3A(21), PDE3B(10), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKG1(18), PRKG2(12), RYR2(138), SLC7A1(6), SYT1(14), TNNI1(2) 25500072 442 203 424 158 119 97 52 112 60 2 0.395 1.000 1.000 236 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(11), BCL2(2), EGFR(115), IGF1R(22), MYC(5), POLR2A(14), PPP2CA(3), PRKCA(8), RB1(139), TEP1(29), TERF1(6), TERT(10), TNKS(11), XRCC5(13) 18639879 388 203 309 156 81 140 42 68 49 8 0.738 1.000 1.000 237 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CAT(8), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADHA(12), KMO(16), KYNU(9), MAOA(7), MAOB(9), SDS(3), TDO2(11), TPH1(4), WARS(4), WARS2(7) 37713531 481 203 450 142 157 91 52 128 52 1 0.0183 1.000 1.000 238 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(7), CDC40(7), CLK2(3), CLK3(8), CLK4(17), COL2A1(20), CPSF1(15), CPSF2(10), CPSF3(9), CPSF4(5), CSTF1(5), CSTF2(2), CSTF2T(14), CSTF3(13), DDIT3(5), DDX1(15), DDX20(7), DHX15(10), DHX16(20), DHX38(14), DHX8(16), DHX9(13), DICER1(25), DNAJC8(5), FUS(2), GIPC1(4), LSM2(1), METTL3(6), NCBP1(12), NCBP2(2), NONO(13), NUDT21(1), NXF1(11), PABPN1(2), PAPOLA(8), PHF5A(1), POLR2A(14), PPM1G(4), PRPF18(5), PRPF3(9), PRPF4(10), PRPF4B(22), PRPF8(19), PSKH1(2), PTBP1(4), PTBP2(14), RBM17(6), RBM5(15), RNGTT(7), RNMT(6), RNPS1(2), SF3A1(11), SF3A2(5), SF3A3(1), SF3B1(18), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(3), SNRPA1(2), SNRPB(3), SNRPB2(3), SNRPD1(2), SNRPD3(2), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(9), SRPK2(12), SRRM1(18), SUPT5H(20), TXNL4A(2), U2AF1(4), U2AF2(8), XRN2(12) 71972919 636 201 592 202 180 92 66 163 134 1 0.766 1.000 1.000 239 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(2), AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), AFMID(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CARM1(3), CAT(8), CYP1A1(10), CYP1A2(11), CYP1B1(14), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADH(2), HADHA(12), HEMK1(1), HSD17B10(3), HSD17B4(9), INMT(4), KMO(16), KYNU(9), LCMT1(1), LCMT2(6), LNX1(19), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), NFX1(11), OGDH(14), OGDHL(16), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), TDO2(11), TPH1(4), TPH2(12), WARS(4), WARS2(7), WBSCR22(2) 41182103 458 200 427 155 136 81 58 122 61 0 0.277 1.000 1.000 240 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(7), AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PRIM1(5), PRIM2(3), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), TK1(2), TK2(3), TXNRD1(9), TXNRD2(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UPB1(9), UPP1(5), UPP2(6), UPRT(7) 56169458 575 199 549 165 152 92 91 153 87 0 0.00515 1.000 1.000 241 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(5), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CFLAR(3), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), PTPN13(23), RB1(139), RIPK2(5), SPTAN1(30) 26633770 455 198 384 160 71 136 38 114 86 10 0.749 1.000 1.000 242 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 62 ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), CDS1(15), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CHPT1(4), CRLS1(1), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), ESCO1(22), ESCO2(18), ETNK1(3), ETNK2(12), GNPAT(19), GPAM(5), GPD1(3), GPD1L(5), GPD2(11), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(34), MYST4(33), NAT6(2), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(14), SH3GLB1(6) 43812988 506 196 453 189 145 85 68 133 74 1 0.777 1.000 1.000 243 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 16 ABCB1(35), AKT1(11), ATM(237), BAX(16), CDKN1A(2), CPB2(11), CSNK1A1(3), CSNK1D(15), FHL2(3), HIF1A(16), IGFBP3(8), MAPK8(17), MDM2(11), NFKBIB(5), NQO1(1) 13141694 391 196 305 128 59 128 35 93 67 9 0.371 1.000 1.000 244 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(237), ATR(53), CDC25C(6), CHEK1(11), CHEK2(30), YWHAH(5) 10897669 342 196 243 136 44 127 24 73 63 11 0.895 1.000 1.000 245 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(14), ADCY4(14), ADCY6(13), ADCY8(34), CACNA1A(28), CACNA1B(40), GNAS(39), GNAT3(4), GNB1(3), GNB3(6), GNG3(2), GRM4(15), ITPR3(44), KCNB1(22), PDE1A(10), PLCB2(11), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), SCNN1A(8), SCNN1B(8), SCNN1G(12), TAS1R1(13), TAS1R2(22), TAS2R1(5), TAS2R10(10), TAS2R13(9), TAS2R14(2), TAS2R16(7), TAS2R3(6), TAS2R38(7), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(3), TAS2R46(1), TAS2R5(4), TAS2R50(10), TAS2R60(4), TAS2R7(4), TAS2R8(9), TAS2R9(3), TRPM5(5) 35670165 485 195 463 178 183 65 47 112 77 1 0.698 1.000 1.000 246 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 53 ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), CARM1(3), DBH(9), DCT(22), DDC(5), ECH1(2), ESCO1(22), ESCO2(18), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HEMK1(1), HGD(6), HPD(7), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), MYST3(34), MYST4(33), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SH3GLB1(6), TAT(16), TPO(36), TYR(12), TYRP1(6), WBSCR22(2) 39403230 474 194 426 176 135 95 56 124 63 1 0.565 1.000 1.000 247 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 26 ARHGDIB(5), BAG4(10), CASP2(8), CASP3(4), CASP8(20), CRADD(4), DFFA(6), DFFB(2), FADD(1), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MADD(26), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), RB1(139), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TRAF2(8) 24949108 451 194 375 153 88 129 32 103 88 11 0.563 1.000 1.000 248 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1C1(2), AKR1C2(3), AKR1C3(2), AKR1C4(12), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), CYP1A1(10), CYP1A2(11), CYP1B1(14), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2F1(7), CYP2S1(8), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9) 38543255 474 193 418 127 116 98 48 132 79 1 0.00853 1.000 1.000 249 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(7), ACADL(6), ACADM(12), ACOX1(11), ACOX2(8), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP27A1(4), CYP4A11(8), CYP4A22(13), CYP7A1(14), CYP8B1(10), DBI(2), EHHADH(15), FABP1(2), FABP2(9), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FABP7(1), FADS2(12), GK(5), GK2(16), HMGCS2(6), ILK(3), LPL(12), ME1(14), MMP1(6), NR1H3(16), OLR1(10), PCK1(6), PCK2(6), PDPK1(4), PLTP(12), PPARA(7), PPARD(5), PPARG(4), RXRA(8), RXRB(8), RXRG(11), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(7), SLC27A4(3), SLC27A5(9), SLC27A6(20), SORBS1(15), UBC(7), UCP1(8) 44630667 517 192 473 144 163 73 75 132 74 0 0.00366 1.000 1.000 250 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(27), BAD(1), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(18), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), GZMB(5), HELLS(13), IKBKB(9), IKBKG(2), IRF1(6), IRF2(10), IRF3(4), IRF4(5), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP3K1(21), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), NFKBIB(5), NFKBIE(5), PLEKHG5(9), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF10B(8), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFSF10(3), TP73(5), TRAF1(7), TRAF2(8), TRAF3(12) 36525793 443 189 383 135 104 85 49 98 106 1 0.287 1.000 1.000 251 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(6), BAD(1), BRAF(125), CREB1(3), CREB3(6), CREB5(8), DUSP4(6), DUSP6(7), DUSP9(9), EEF2K(11), GRB2(11), MAP2K1(12), MAP2K2(3), MAP3K8(4), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MOS(10), NFKB1(11), RAP1A(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), SHC1(14), SOS1(16), SOS2(17), TRAF3(12) 20384970 362 187 270 115 68 98 40 105 50 1 0.159 1.000 1.000 252 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(32), CARM1(3), CCND1(2), CREBBP(81), EP300(56), ERCC3(19), ESR1(21), GRIP1(15), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), MEF2C(15), NCOR2(44), NR0B1(11), NRIP1(18), PELP1(11), POLR2A(14), SRA1(3), TBP(2) 31101277 431 186 375 191 113 89 45 82 102 0 0.997 1.000 1.000 253 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CHEK1(11), MYT1(25), WEE1(15), YWHAH(5) 9731376 321 185 248 108 54 113 24 74 48 8 0.307 1.000 1.000 254 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(42), AR(26), ESR1(21), ESR2(8), HNF4A(12), NPM1(3), NR0B1(11), NR1D1(8), NR1D2(10), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(5), NR2C2(11), NR2E1(13), NR2F1(6), NR2F2(11), NR3C1(11), NR4A1(3), NR4A2(16), NR5A1(5), NR5A2(9), PGR(16), PPARA(7), PPARD(5), PPARG(4), RARA(6), RARB(20), RARG(10), ROR1(23), RORA(6), RORC(6), RXRA(8), RXRB(8), RXRG(11), THRA(6), THRB(14), VDR(4) 26843553 406 185 379 136 138 71 47 91 57 2 0.247 1.000 1.000 255 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 34 AKT1(11), ATF2(7), CDC42(3), DLD(4), DUSP10(6), DUSP4(6), GAB1(15), GCK(6), IL1R1(7), JUN(2), MAP2K5(6), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK10(18), MAPK7(6), MAPK8(17), MAPK9(13), MYEF2(14), NFATC3(15), NR2C2(11), PAPPA(39), SHC1(14), TRAF6(4), ZAK(12) 32319345 424 185 371 116 113 69 54 97 89 2 0.0503 1.000 1.000 256 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(12), AGTR2(17), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDK5(3), F2(10), FYN(17), GNA11(8), GNAI1(5), GNB1(3), GNGT1(1), GRB2(11), HRAS(4), JAK2(55), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MAPT(11), MYLK(33), PLCG1(19), PRKCA(8), PTK2B(13), RAF1(16), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), SYT1(14) 28812736 403 184 345 147 102 110 47 82 58 4 0.605 1.000 1.000 257 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AGK(7), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CEL(13), DAK(8), DGAT1(5), DGAT2(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), GK(5), GK2(16), GLA(7), GLB1(9), GPAM(5), LCT(46), LIPA(3), LIPC(6), LIPF(3), LIPG(4), LPL(12), MGLL(2), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3) 39025910 468 184 432 178 131 73 67 144 52 1 0.655 1.000 1.000 258 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(12), AGTR1(14), ATF2(7), CALM2(1), CALM3(1), EGFR(115), ELK1(4), GNAQ(11), GRB2(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), MEF2A(7), MEF2C(15), MEF2D(3), PAK1(11), PRKCA(8), PTK2(24), PTK2B(13), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SRC(3), SYT1(14) 22756844 388 182 341 138 82 115 44 95 51 1 0.440 1.000 1.000 259 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(45), CSF1R(16), EGF(8), EGFR(115), GRB2(11), MET(55), PDGFRA(64), PRKCA(8), SH3GLB1(6), SH3GLB2(6), SH3KBP1(8), SRC(3) 13825164 345 182 298 143 51 143 48 78 23 2 0.671 1.000 1.000 260 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 88 ANK2(84), B3GALT4(4), CDR1(8), DGKI(22), FAU(2), IL6ST(15), MRPL19(4), PIGK(12), RPL10(3), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(6), RPL6(4), RPL7(4), RPL7A(1), RPL8(3), RPL9(4), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(2), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS4X(3), RPS5(2), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), RPS7(1), RPS9(3), RPSA(1), SLC36A2(6), TSPAN9(5), UBA52(3), UBB(3), UBC(7) 33919000 378 181 355 108 98 76 51 94 57 2 0.122 1.000 1.000 261 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(81), DAXX(18), HRAS(4), PAX3(26), PML(12), RARA(6), RB1(139), SIRT1(8), SP100(15), TNF(2), TNFRSF1A(4), TNFRSF1B(1) 11937104 316 180 243 121 73 113 23 52 47 8 0.572 1.000 1.000 262 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), HSD3B7(3), NSD1(29), OGDH(14), OGDHL(16), PIPOX(9), PLOD1(8), PLOD2(10), PLOD3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SETD1A(21), SETD7(9), SETDB1(19), SHMT1(7), SHMT2(5), SPCS1(3), SPCS3(2), SUV39H1(4), SUV39H2(7), TMLHE(6) 38267916 398 176 366 120 135 63 41 92 67 0 0.0981 1.000 1.000 263 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(35), ATP4A(20), ATP4B(3), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5L(2), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), COX10(6), COX15(8), COX17(1), COX4I1(5), COX4I2(4), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(6), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(3), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(8), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(4), NDUFC1(1), NDUFC2(2), NDUFS1(16), NDUFS2(6), NDUFS3(4), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(5), PPA1(3), PPA2(5), SDHA(14), SDHB(3), SDHD(4), TCIRG1(7), UQCRB(2), UQCRC1(4), UQCRC2(13), UQCRFS1(3), UQCRH(1) 38676698 450 175 409 130 145 90 54 86 75 0 0.00779 1.000 1.000 264 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 40 ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHFR(1), DHX58(6), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), FPGS(4), GGH(2), IFIH1(22), MOV10L1(23), NUDT5(1), QDPR(2), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SKIV2L2(13), SMARCA2(22), SMARCA5(18), SPR(7) 42240555 478 174 432 156 149 83 53 106 85 2 0.327 1.000 1.000 265 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), BCR(12), CAPN1(2), CAPNS1(4), CAPNS2(4), CAV1(1), CRKL(5), CSK(5), FYN(17), GRB2(11), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MAPK8(17), PPP1R12B(33), PTK2(24), PXN(2), RAF1(16), RAP1A(2), ROCK1(35), SHC1(14), SOS1(16), SRC(3), TLN1(23), VCL(10), ZYX(5) 30770205 372 173 318 123 105 67 43 78 73 6 0.381 1.000 1.000 266 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), F10(5), F11(8), F12(5), F2(10), F2R(11), F5(37), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), PROC(3), PROS1(12), SERPINC1(8), SERPING1(7) 31265399 375 172 347 149 83 72 55 99 64 2 0.679 1.000 1.000 267 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(27), CREBBP(81), DUSP1(7), EP300(56), IKBKB(9), IL1B(5), IL8(6), MAP2K3(11), MAP2K6(5), MAP3K14(6), MAP3K7(9), MAPK14(8), MYD88(4), NFKB1(11), NFKBIA(1), NR3C1(11), RELA(10), TGFBR1(20), TGFBR2(26), TLR2(12), TNF(2) 20033236 327 172 281 114 87 98 34 63 44 1 0.294 1.000 1.000 268 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(45), EGF(8), EGFR(115), GRB2(11), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), PTPRB(21), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SPRY1(10), SPRY2(2), SPRY4(7), SRC(3) 16287639 315 172 267 109 64 107 48 60 35 1 0.195 1.000 1.000 269 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), CEL(13), DGAT1(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), GK(5), GLA(7), GLB1(9), LCT(46), LIPC(6), LIPF(3), LIPG(4), LPL(12), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PPAP2A(2), PPAP2B(2), PPAP2C(3) 31815098 404 171 370 144 112 73 57 115 46 1 0.347 1.000 1.000 270 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(6), ACTG2(6), ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), CDC42(3), CFL1(2), CFL2(2), FLNA(31), FLNC(39), FSCN1(5), FSCN3(6), GDI1(1), GDI2(2), LIMK1(8), MYH2(42), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PFN2(4), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), VASP(4), WASF1(6), WASL(18) 30035145 406 171 373 137 120 63 49 89 80 5 0.286 1.000 1.000 271 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ENPP1(17), ENPP3(12), G6PC(5), GAA(14), GANAB(13), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), MGAM(26), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), SI(28), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UXS1(9) 40341344 392 171 375 118 112 71 49 83 76 1 0.123 1.000 1.000 272 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPS(6), CDS1(15), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CLC(3), CPT1B(14), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), ETNK1(3), GNPAT(19), GPD1(3), GPD2(11), LCAT(4), LGALS13(5), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(7), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB2(11), PLCG1(19), PLCG2(28), PPAP2A(2), PPAP2B(2), PPAP2C(3) 32486698 381 170 343 150 129 56 50 89 57 0 0.850 1.000 1.000 273 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(7), ACSS2(10), ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), G6PC2(3), GALM(3), GAPDH(2), GAPDHS(3), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3) 38703646 427 170 386 146 135 79 44 111 58 0 0.280 1.000 1.000 274 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(9), ACOX1(11), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP4A11(8), CYP4A22(13), DCI(4), ECHS1(4), EHHADH(15), GCDH(8), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), PECI(2) 33630441 389 170 355 118 103 74 63 98 51 0 0.0180 1.000 1.000 275 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(27), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(5), GNAI1(5), GNAQ(11), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAF1(16), RPS6KA3(16), SYT1(14) 22182296 292 169 249 97 116 69 24 47 36 0 0.109 1.000 1.000 276 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(7), IFNG(3), IFNGR1(8), IFNGR2(5), IKBKB(9), JAK2(55), LIN7A(7), NFKB1(11), NFKBIA(1), RB1(139), RELA(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), USH1C(15), WT1(32) 11761111 309 169 233 118 54 127 24 55 37 12 0.595 1.000 1.000 277 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), CSK(5), CTNNA1(28), CTNNA2(38), CTNNB1(120), PTK2(24), PXN(2), SRC(3), VCL(10) 12330090 274 168 216 107 63 79 34 69 28 1 0.725 1.000 1.000 278 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(14), CAPN1(2), CAPN2(10), CAPNS1(4), CAPNS2(4), CXCR3(5), EGF(8), EGFR(115), HRAS(4), ITGA1(12), ITGB1(13), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTK2(24), PXN(2), TLN1(23) 22698575 317 168 293 131 75 94 50 64 33 1 0.715 1.000 1.000 279 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(27), BAD(1), BAX(16), BCL2(2), BCL2A1(5), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CD40(7), CD40LG(10), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), IKBKE(9), LTA(1), NFKB1(11), NFKBIA(1), NGFR(5), NR3C1(11), NTRK1(17), PTPN13(23), RIPK1(7), SFRS2IP(3), TFG(8), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12), TRAF6(4) 28956784 319 165 281 147 66 78 31 69 74 1 1.000 1.000 1.000 280 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 66 CALR(2), CANX(5), CD4(4), CD74(3), CD8A(2), CD8B(4), CIITA(18), CREB1(3), CTSB(6), CTSL1(8), CTSS(4), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA2(6), HLA-DQB1(2), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), HSP90AA1(9), HSP90AB1(4), HSPA5(5), IFI30(3), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(10), KIR2DL4(5), KIR2DS4(4), KIR3DL1(10), KIR3DL2(7), KIR3DL3(11), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LGMN(3), LTA(1), NFYA(5), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(15), RFXANK(1), RFXAP(5), TAP1(9), TAP2(16), TAPBP(6) 27307902 355 165 331 116 66 67 45 99 66 12 0.416 1.000 1.000 281 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(6), GTF2A1L(13), GTF2A2(1), GTF2B(12), GTF2E1(13), GTF2E2(1), GTF2F1(7), GTF2F2(1), GTF2H1(6), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(19), TAF1(32), TAF10(1), TAF12(4), TAF13(3), TAF1L(66), TAF2(20), TAF4(11), TAF4B(11), TAF5(13), TAF5L(3), TAF6(9), TAF6L(5), TAF7(3), TAF7L(14), TAF9(3), TAF9B(1), TBPL1(3), TBPL2(2) 25193065 292 164 259 87 79 52 32 80 48 1 0.168 1.000 1.000 282 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IL6(7), IL6R(8), IL6ST(15), JAK1(22), JAK2(55), JAK3(31), JUN(2), MAP2K1(12), MAPK3(4), PTPN11(41), RAF1(16), SHC1(14), SOS1(16), SRF(4), STAT3(10) 16194606 288 164 219 89 63 101 34 50 35 5 0.132 1.000 1.000 283 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), RB1(139), RBL1(21), TFDP1(10) 10864390 263 163 207 100 47 86 20 61 41 8 0.548 1.000 1.000 284 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(6), ABO(7), B3GALNT1(6), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(5), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALNT1(13), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT6(10), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GBGT1(1), GCNT2(26), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGX(4), PIGZ(6), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(16), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10), UGCG(9) 31239428 378 162 340 123 116 65 28 97 71 1 0.519 1.000 1.000 285 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), AGMAT(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH4A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), GAMT(6), GATM(2), GLUD1(4), GOT1(7), GOT2(2), MAOA(7), MAOB(9), NOS1(31), NOS3(23), OAT(4), ODC1(8), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(6), RARS(9), SMS(4) 29618054 368 161 332 117 124 60 47 81 56 0 0.131 1.000 1.000 286 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3) 32858197 381 161 340 124 119 79 39 97 47 0 0.129 1.000 1.000 287 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3) 32858197 381 161 340 124 119 79 39 97 47 0 0.129 1.000 1.000 288 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(8), ACAA1(7), ACAA2(4), ACADM(12), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), AOX1(15), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(4), ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HADHB(10), HIBADH(2), HIBCH(3), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), OXCT2(3), PCCA(17), PCCB(6) 30325901 324 161 293 82 96 58 41 67 61 1 0.00470 1.000 1.000 289 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(17), AGT(12), AGTR2(17), EDN1(3), EDNRA(9), EDNRB(19), EGF(8), EGFR(115), FOS(5), HRAS(4), JUN(2), MYC(5), NFKB1(11), PLCG1(19), PRKCA(8), RELA(10) 14190326 264 160 230 108 63 75 41 54 31 0 0.777 1.000 1.000 290 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(15), COPS5(2), CREB1(3), EDN1(3), EP300(56), EPO(1), HIF1A(16), JUN(2), LDHA(14), NOS3(23), P4HB(6), VHL(105) 11126917 255 160 190 88 41 96 35 43 40 0 0.259 1.000 1.000 291 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(8), ACACA(36), ACACB(40), ACADM(12), ACAT1(7), ACAT2(9), ACSS1(7), ACSS2(10), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), HIBCH(3), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SUCLA2(9), SUCLG1(3), SUCLG2(1) 28010401 337 159 304 71 99 53 50 76 59 0 9.17e-05 1.000 1.000 292 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 30 ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), DRD1(9), DRD2(9), DRD3(6), DRD5(14), HRH1(4), HRH2(16), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13) 16283720 315 158 277 110 128 61 38 54 33 1 0.0567 1.000 1.000 293 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ITPA(6), NME1(1), NT5C(1), NT5E(7), NT5M(3), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), RRM1(3), RRM2(5), TK1(2), TK2(3), TXNRD1(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UNG(3), UPB1(9), UPP1(5) 38761888 391 158 374 123 108 63 58 110 52 0 0.131 1.000 1.000 294 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(12), AKR1D1(9), ARSD(9), ARSE(4), CARM1(3), CYP11B1(17), CYP11B2(7), CYP19A1(11), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), WBSCR22(2) 33084863 348 157 329 106 90 64 41 88 65 0 0.0935 1.000 1.000 295 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 19 ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNAS(39), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12) 14468903 266 156 228 89 87 70 24 46 37 2 0.191 1.000 1.000 296 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 19 ADCY1(27), CD3D(5), CD3E(2), CD4(4), CREBBP(81), CSK(5), GNAS(39), GNB1(3), GNGT1(1), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12) 14468903 266 156 228 89 87 70 24 46 37 2 0.191 1.000 1.000 297 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(30), EEF1A2(8), EEF1B2(3), EEF1D(12), EEF1G(1), EEF2(7), EEF2K(11), EIF1AX(1), EIF2AK1(16), EIF2AK2(5), EIF2AK3(14), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF4A2(12), EIF4EBP2(4), EIF4G1(19), EIF4G3(19), EIF5(6), EIF5A(3), EIF5B(20), ETF1(13), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(23), PAIP1(7), SLC35A4(3) 29310599 313 156 268 82 71 72 29 70 71 0 0.0443 1.000 1.000 298 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(2), BTK(12), CALM2(1), CALM3(1), CD79A(6), CD79B(3), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK14(8), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24) 25300891 309 155 275 95 95 70 34 63 46 1 0.107 1.000 1.000 299 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(8), ADC(3), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EARS2(3), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GFPT2(12), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), GMPS(16), GNPNAT1(1), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSR(5), GSS(9), NADSYN1(4), NAGK(7), PPAT(8), QARS(14) 27172490 303 155 281 83 85 59 37 85 37 0 0.0280 1.000 1.000 300 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(36), ACACB(40), ACAT1(7), ACAT2(9), ACOT12(11), ACSS1(7), ACSS2(10), ACYP1(2), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PCK2(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4) 32074289 374 155 342 118 112 64 50 89 59 0 0.157 1.000 1.000 301 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(6), ACTG2(6), ADCY3(11), ADCY9(22), AK1(2), ARF1(1), ARF4(5), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ERO1L(4), GNAS(39), PDIA4(9), PLCG1(19), PLCG2(28), PRKCA(8), SEC61A1(10), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(18) 25093398 309 155 257 104 116 68 31 55 39 0 0.199 1.000 1.000 302 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG5(5), ALG6(5), ALG8(13), ALG9(8), B4GALT1(8), B4GALT2(7), B4GALT3(8), DAD1(3), DDOST(4), DHDDS(6), DPAGT1(14), DPM1(3), FUT8(11), GANAB(13), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), RFT1(3), RPN1(4), RPN2(7), ST6GAL1(3), STT3B(11) 27880274 325 154 293 112 84 57 34 88 62 0 0.819 1.000 1.000 303 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 29 ACTR2(2), ACTR3(5), ARHGAP1(3), ARHGAP4(7), ARHGAP6(11), ARHGEF1(15), ARHGEF11(24), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), BAIAP2(7), CFL1(2), DIAPH1(7), GSN(4), LIMK1(8), MYL2(2), MYLK(33), OPHN1(11), PIP5K1A(7), PIP5K1B(4), PPP1R12B(33), ROCK1(35), SRC(3), TLN1(23), VCL(10) 29742991 285 154 247 91 83 41 27 63 66 5 0.594 1.000 1.000 304 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), ESCO1(22), ESCO2(18), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), PRDX6(5), SH3GLB1(6), TAT(16), TPO(36) 22992331 317 153 275 103 110 53 37 69 47 1 0.189 1.000 1.000 305 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 30 ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), DBH(9), DCT(22), DDC(5), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HGD(6), HPD(7), MAOA(7), MAOB(9), PNMT(3), TAT(16), TPO(36), TYR(12) 20736047 272 153 238 100 87 52 33 69 31 0 0.363 1.000 1.000 306 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), AOX1(15), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), HIBADH(2), HMGCL(1), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), PCCA(17), PCCB(6), SDS(3) 25203908 308 153 277 72 88 55 41 71 52 1 0.000551 1.000 1.000 307 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(4), ACY3(4), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(10), ASPA(8), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(12), HARS(6), HARS2(8), HDC(14), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), PRPS1(9), PRPS2(6), UROC1(10), WBSCR22(2) 26040708 300 152 278 92 87 61 42 74 36 0 0.0497 1.000 1.000 308 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(8), ABP1(4), ACADL(6), ACADM(12), ACADSB(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), MLYCD(4), SDS(3), SMS(4), UPB1(9) 20034021 296 150 271 79 87 47 45 80 37 0 0.00356 1.000 1.000 309 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(10), CDC7(25), CDK2(5), DIAPH2(28), GMNN(5), MCM10(12), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), PRIM1(5), RFC1(25), RFC2(3), RFC4(8), RFC5(8), RPA1(12), RPA2(1), RPA3(4), RPA4(6), UBA52(3), UBB(3), UBC(7) 33914887 349 148 301 107 68 62 47 93 78 1 0.369 1.000 1.000 310 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(8), AGXT2(9), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), ATP6V0C(1), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CPT1B(14), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), MAOA(7), MAOB(9), PEMT(2), PISD(8), PLCB2(11), PLCG1(19), PLCG2(28), PSPH(2), SARDH(17), SARS(6), SHMT1(7), SHMT2(5), TARS(10) 28265420 315 148 287 118 118 46 39 63 49 0 0.661 1.000 1.000 311 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(2), ALOX12(4), ALOX12B(6), ALOX15(5), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP2U1(5), CYP4A11(8), CYP4A22(13), CYP4F2(12), CYP4F3(11), DHRS4(1), EPHX2(5), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13) 26624421 287 148 263 97 92 39 36 74 45 1 0.452 1.000 1.000 312 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(11), CFL1(2), GNAQ(11), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), LIMK1(8), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), NOX1(4), PIK3C2G(21), PLCB1(23), PPP1R12B(33), PRKCA(8), PTK2(24), RAF1(16), ROCK2(20) 16889460 251 147 201 73 79 50 20 51 50 1 0.202 1.000 1.000 313 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 44 AACS(9), AADAC(7), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ACSM1(10), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH7A1(8), ALDH9A1(4), BDH1(4), BDH2(2), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADH(2), HADHA(12), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), HSD3B7(3), ILVBL(9), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(8), PDHA2(17), PDHB(3), PLA1A(10), PPME1(2), PRDX6(5), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 27133702 310 147 280 100 102 56 39 75 38 0 0.0859 1.000 1.000 314 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(35), ATP4B(3), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ATP7A(13), ATP7B(16), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3), PPA2(5), SDHA(14), SDHB(3), SHMT1(7), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1) 26969228 296 147 267 93 90 52 38 62 54 0 0.127 1.000 1.000 315 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(7), BCR(12), BLNK(2), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8IP3(12), PAPPA(39), RAC1(2), RPS6KA1(9), RPS6KA3(16), SHC1(14), SOS1(16), SYK(8), VAV1(24), VAV2(20), VAV3(30) 20917090 290 146 258 71 83 61 36 75 34 1 0.00205 1.000 1.000 316 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(5), AKT1(11), AKT2(8), AKT3(8), DAG1(10), GNAQ(11), IKBKG(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PIK3CB(6), PITX2(2), PLD1(19), PLD2(10), PLD3(7), VN1R1(7) 28429292 314 146 306 103 103 60 39 70 41 1 0.187 1.000 1.000 317 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), ELK1(4), FPR1(8), GNA15(6), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NCF1(4), NCF2(10), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PAK1(11), PIK3C2G(21), PLCB1(23), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAC1(2), RAF1(16), RELA(10), SYT1(14) 25078048 296 145 273 104 100 51 33 70 41 1 0.385 1.000 1.000 318 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(8), ACACA(36), ACADL(6), ACADM(12), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), LDHA(14), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SDS(3), SUCLA2(9), SUCLG1(3), SUCLG2(1) 23384916 301 145 268 64 87 52 43 67 52 0 0.000235 1.000 1.000 319 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(36), ACAT1(7), ACAT2(9), ACYP1(2), ADH5(7), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHA(14), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4) 25038141 315 144 282 104 92 62 40 75 46 0 0.253 1.000 1.000 320 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(27), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), FADD(1), FAS(9), FASLG(3), GZMB(5), IKBKG(2), JUN(2), MAP3K1(21), MAP3K14(6), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), PARP1(17), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(3), TRAF1(7), TRAF2(8) 23844461 282 143 242 86 65 54 33 56 73 1 0.280 1.000 1.000 321 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F11(8), F12(5), F13B(12), F2(10), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), LPA(30), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10), SERPINF2(4), VWF(36) 24266775 325 143 295 129 81 61 48 83 49 3 0.823 1.000 1.000 322 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(10), AARS2(13), CARS(11), CARS2(6), DARS(5), DARS2(8), EARS2(3), EPRS(27), FARS2(7), FARSA(6), FARSB(12), GARS(8), HARS(6), HARS2(8), IARS(10), IARS2(19), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), MTFMT(1), NARS(5), NARS2(11), PARS2(2), QARS(14), RARS(9), RARS2(10), SARS(6), SARS2(4), TARS(10), TARS2(10), VARS(7), VARS2(9), WARS(4), WARS2(7), YARS(4), YARS2(7) 36535307 328 143 319 84 103 43 44 88 50 0 0.0279 1.000 1.000 323 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 33 AKT1(11), AKT2(8), AKT3(8), ARHGEF11(24), BCL2(2), CDC42(3), DLG4(10), GNA13(3), IKBKG(2), LPA(30), MAP3K1(21), MAP3K5(16), MAPK8(17), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PI3(3), PIK3CB(6), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RDX(16), ROCK1(35), ROCK2(20), SERPINA4(10), SRF(4) 32302569 363 143 338 112 108 54 33 99 64 5 0.387 1.000 1.000 324 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 32 AKT1(11), ATF1(6), CDC42(3), CREB1(3), CREB3(6), CREB5(8), DUSP1(7), DUSP10(6), EEF2K(11), ELK1(4), IL1R1(7), MAP2K3(11), MAP2K6(5), MAP3K10(11), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MKNK1(4), MKNK2(7), MYEF2(14), NFKB1(11), NR2C2(11), SRF(4), TRAF6(4) 21860849 265 143 236 73 69 46 40 60 49 1 0.0445 1.000 1.000 325 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(8), AGXT2(9), AKR1B10(3), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), GNMT(3), HSD3B7(3), MAOA(7), MAOB(9), PEMT(2), PHGDH(3), PIPOX(9), PISD(8), PSAT1(7), PSPH(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SARDH(17), SARS(6), SARS2(4), SDS(3), SHMT1(7), SHMT2(5), TARS(10), TARS2(10) 29237069 303 142 286 109 110 39 39 72 43 0 0.511 1.000 1.000 326 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(28), GABBR1(20), GPRC5A(5), GPRC5B(4), GPRC5C(10), GPRC5D(3), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM7(36), GRM8(29) 13402320 257 141 223 103 104 34 32 53 34 0 0.630 1.000 1.000 327 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(8), ABP1(4), ACADM(12), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HIBCH(3), MLYCD(4), SMS(4), SRM(1), UPB1(9) 18476994 263 141 239 77 76 42 41 70 34 0 0.0364 1.000 1.000 328 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ATP6V0C(1), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADHA(12), PLOD1(8), PLOD2(10), PLOD3(7), SDS(3), SHMT1(7), SHMT2(5), TMLHE(6) 23744664 279 141 251 71 81 53 38 64 43 0 0.00219 1.000 1.000 329 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(6), CHUK(27), ELK1(4), FOS(5), IKBKB(9), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), PPARA(7), RELA(10), TIRAP(5), TLR10(14), TLR2(12), TLR3(15), TLR4(18), TLR6(14), TLR7(18), TLR9(16), TOLLIP(5), TRAF6(4) 24124288 296 141 283 79 76 57 27 86 48 2 0.0458 1.000 1.000 330 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(8), EGFR(115), MAP2K1(12), MAP3K1(21), MAPK14(8), NCOR2(44), RARA(6), RXRA(8), THRA(6), THRB(14) 11147728 242 140 207 92 57 70 36 46 33 0 0.688 1.000 1.000 331 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(3), B4GALT1(8), B4GALT2(7), G6PC(5), G6PC2(3), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANC(9), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), HSD3B7(3), LALBA(2), LCT(46), MGAM(26), PFKL(7), PFKM(5), PFKP(16), PGM1(10), PGM3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), UGP2(12) 24841549 283 139 272 100 103 43 31 77 29 0 0.324 1.000 1.000 332 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(7), ACAA2(4), ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1B10(3), AKR1C4(12), AKR1D1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), HSD3B7(3), LIPA(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SLC27A5(9), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2) 21633822 261 139 235 74 66 55 38 70 31 1 0.0322 1.000 1.000 333 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 36 ATF2(7), CDC42(3), CREB1(3), DAXX(18), DDIT3(5), ELK1(4), GRB2(11), HRAS(4), HSPB2(3), MAP2K6(5), MAP3K1(21), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MYC(5), PLA2G4A(16), RAC1(2), RIPK1(7), RPS6KA5(13), SHC1(14), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8) 24221369 290 137 263 88 85 66 28 64 46 1 0.189 1.000 1.000 334 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(8), B4GALT2(7), FBP2(5), G6PC(5), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANAB(13), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), LALBA(2), LCT(46), MGAM(26), PFKM(5), PFKP(16), PGM1(10), PGM3(7) 21134447 248 136 239 93 90 44 27 61 26 0 0.538 1.000 1.000 335 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CYP2C19(12), CYP2C9(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), HADHA(12), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3) 21011582 281 136 247 82 71 62 37 68 42 1 0.0906 1.000 1.000 336 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREB1(3), CREBBP(81), EP300(56), NCOA3(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RARA(6), RXRA(8) 14144361 213 135 187 87 52 56 28 41 36 0 0.754 1.000 1.000 337 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(10), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(8), ADSSL1(6), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), ASRGL1(1), ASS1(5), CAD(23), CRAT(11), DARS(5), DARS2(8), DDO(6), DLAT(10), DLD(4), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), NARS2(11), PC(16), PDHA1(8), PDHA2(17), PDHB(3) 25476532 280 135 263 109 96 39 41 64 40 0 0.747 1.000 1.000 338 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(1), ALAS1(12), ALAS2(12), BLVRA(2), BLVRB(2), COX10(6), COX15(8), CP(24), CPOX(4), EARS2(3), EPRS(27), FECH(4), FTH1(1), FTMT(8), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), MMAB(2), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UROD(3), UROS(5) 28229195 298 135 269 72 67 55 39 80 57 0 0.0271 1.000 1.000 339 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(27), CREBBP(81), EP300(56), FADD(1), HDAC3(3), IKBKB(9), IKBKG(2), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 15327977 219 135 188 81 59 66 23 36 35 0 0.463 1.000 1.000 340 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(4), BFAR(9), BRAF(125), CAMP(1), CREB1(3), CREB3(6), CREB5(8), MAPK1(3), RAF1(16), SRC(3), TERF2IP(4) 6867563 182 135 103 61 19 58 17 72 16 0 0.428 1.000 1.000 341 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(8), ARG1(2), ARG2(6), ASL(5), ASS1(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), EPRS(27), GAMT(6), GATM(2), GLUD1(4), GLUD2(22), GOT1(7), GOT2(2), LAP3(4), NOS1(31), NOS3(23), OAT(4), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(2), PRODH(5), RARS(9), RARS2(10) 23926762 279 134 257 86 89 38 41 69 42 0 0.175 1.000 1.000 342 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), PON1(12) 19550871 255 133 246 77 98 42 22 63 28 2 0.0872 1.000 1.000 343 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GAPDHS(3), GCK(6), GOT1(7), GOT2(2), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHAL6B(7), LDHB(8), LDHC(4), MDH1(8), MDH2(3), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PKLR(12), PKM2(4), TNFAIP1(4), TPI1(3) 28154287 295 133 268 122 113 49 27 67 39 0 0.849 1.000 1.000 344 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ACY1(6), ADC(3), AGMAT(7), ALDH18A1(8), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), ASS1(5), CPS1(39), GATM(2), MAOA(7), MAOB(9), NAGS(6), ODC1(8), OTC(17), SAT1(5), SAT2(2), SMS(4), SRM(1) 20265396 244 133 217 71 73 50 31 59 31 0 0.0570 1.000 1.000 345 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PLCG1(19), PTPN6(4), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20) 14736094 223 132 182 75 54 70 21 40 34 4 0.597 1.000 1.000 346 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(8), EGFR(115), ERBB3(32), NRG1(33), UBE2D1(1) 7284913 189 132 159 67 43 69 26 35 16 0 0.334 1.000 1.000 347 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(6), CDK2(5), CDKN1B(6), CKS1B(2), CUL1(17), NEDD8(1), RB1(139), RBX1(1), SKP2(3), TFDP1(10), UBE2M(2) 6024134 192 132 139 73 31 70 10 38 35 8 0.660 1.000 1.000 348 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(18), CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), SKP2(3), TFDP1(10) 6148005 200 132 145 78 34 73 10 44 31 8 0.619 1.000 1.000 349 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(27), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), GAS2(4), LMNA(1), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), SPTAN1(30), TNFRSF10A(8), TNFRSF10B(8), TNFRSF25(2), TNFSF10(3), TNFSF12(2), TRAF2(8) 22591935 240 131 209 79 57 52 27 54 49 1 0.485 1.000 1.000 350 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), NOS1(31), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), SYT1(14) 16989570 238 131 222 100 85 43 22 51 36 1 0.781 1.000 1.000 351 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(9), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(8), PDHA2(17), PDHB(3), SDHB(3), SDS(3) 17956584 242 130 215 68 72 46 34 60 30 0 0.0170 1.000 1.000 352 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IL2(5), IL2RA(6), IL2RB(5), IL2RG(9), JAK1(22), JAK3(31), JUN(2), LCK(9), MAP2K1(12), MAPK3(4), MAPK8(17), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8) 15861493 237 130 195 59 59 56 24 46 50 2 0.0472 1.000 1.000 353 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(4), ALOX15(5), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(11), EPX(14), GGT1(11), LPO(10), LTA4H(2), MPO(17), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13), TPO(36) 18683209 227 130 207 73 93 28 27 42 37 0 0.168 1.000 1.000 354 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(7), ACAA2(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AKR1C4(12), AKR1D1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), SOAT2(4), SRD5A1(2), SRD5A2(2) 15991332 223 129 198 52 54 51 31 59 27 1 0.00182 1.000 1.000 355 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(8), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), GMPS(16), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSS(9), NADSYN1(4), PPAT(8), QARS(14) 22869210 250 129 228 64 65 53 31 70 31 0 0.0209 1.000 1.000 356 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(14), ADCY1(27), CAP1(5), CCNB1(8), CDC25C(6), GNAI1(5), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), MAPK1(3), MAPK3(4), MYT1(25), PIN1(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KA1(9), SRC(3) 13313794 193 129 170 56 84 37 21 36 15 0 0.0166 1.000 1.000 357 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(6), CALM2(1), CALM3(1), CRKL(5), GNAQ(11), GRB2(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), PAK1(11), PLCG1(19), PRKCA(8), PTK2B(13), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SRC(3), SYT1(14) 18583106 236 129 206 80 56 56 25 65 33 1 0.541 1.000 1.000 358 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(15), POLA2(6), POLB(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLG(9), POLG2(4), POLH(16), POLK(11), POLL(2), POLM(12), POLQ(42), PRIM1(5), PRIM2(3), REV1(16), REV3L(45), RFC5(8) 27921628 285 128 260 87 65 42 38 81 57 2 0.457 1.000 1.000 359 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ABP1(4), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B2(8), ALDH9A1(4), AOC2(12), AOC3(10), ASPA(8), CNDP1(7), DDC(5), HAL(12), HARS(6), HDC(14), HNMT(11), MAOA(7), MAOB(9), PRPS1(9), PRPS2(6) 16485179 221 126 197 55 66 46 31 56 22 0 0.00259 1.000 1.000 360 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CALM2(1), CALM3(1), CHUK(27), EGR2(16), EGR3(6), GNAQ(11), MAP3K1(21), MYC(5), NFATC2(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), SYT1(14), VIP(3), VIPR2(11) 17855655 227 126 205 73 70 50 24 44 39 0 0.182 1.000 1.000 361 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(15), AGT(12), AGTR1(14), AGTR2(17), CMA1(1), COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), REN(10) 18109524 216 125 205 72 54 30 29 60 43 0 0.100 1.000 1.000 362 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(5), CALCR(12), CALCRL(9), CD97(12), CRHR1(6), CRHR2(6), ELTD1(14), EMR1(17), EMR2(11), GHRHR(2), GIPR(1), GLP1R(11), GLP2R(10), GPR64(19), LPHN1(20), LPHN2(30), LPHN3(30), SCTR(6), VIPR1(7), VIPR2(11) 18379554 239 125 235 99 79 37 20 74 29 0 0.764 1.000 1.000 363 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(3), ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), FUK(9), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), HSD3B7(3), KHK(4), LHPP(6), MPI(4), MTMR1(13), MTMR2(8), MTMR6(11), PFKFB1(14), PFKFB2(5), PFKFB3(3), PFKFB4(5), PFKL(7), PFKM(5), PFKP(16), PGM2(4), PHPT1(2), PMM1(5), PMM2(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SORD(2), TPI1(3), TSTA3(1) 25000486 252 125 234 95 97 36 26 61 32 0 0.575 1.000 1.000 364 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(81), EP300(56), LPL(12), NCOA1(15), NCOA2(23), PPARG(4), RXRA(8) 12259823 199 125 178 83 50 56 28 37 28 0 0.735 1.000 1.000 365 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(5), NFYB(2), NFYC(10), RB1(139), SP1(7), SP3(13) 4757427 176 125 123 59 23 74 10 37 24 8 0.121 1.000 1.000 366 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), P4HB(6), SLC23A1(10), SLC23A2(18), SLC2A1(7), SLC2A3(13) 17893323 201 125 188 77 52 26 31 51 41 0 0.268 1.000 1.000 367 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CCR5(11), CD3D(5), CD3E(2), CXCR3(5), ETV5(15), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), JAK2(55), JUN(2), MAP2K6(5), MAPK14(8), MAPK8(17), STAT4(13), TYK2(5) 12667138 193 124 168 78 31 69 25 47 18 3 0.818 1.000 1.000 368 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TAT(16), TPO(36) 14444897 203 124 177 62 84 28 25 38 28 0 0.0672 1.000 1.000 369 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(19), EGF(8), EGFR(115), HGS(10), RAB5A(4), TF(21), TFRC(7) 8917235 184 123 158 72 35 67 25 37 19 1 0.409 1.000 1.000 370 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 28 B4GALT5(5), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GCNT1(9), GCNT3(6), GCNT4(14), OGT(10), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(6) 21606286 249 123 238 96 76 40 34 66 33 0 0.857 1.000 1.000 371 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(25), C5(25), C6(27), C7(11), ICAM1(4), IL1A(1), IL6(7), IL8(6), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELP(15), TNF(2), VCAM1(15) 16334425 210 123 200 73 69 29 21 50 40 1 0.343 1.000 1.000 372 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), DAG1(10), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFAT5(6), PDE6A(14), PDE6B(11), PDE6C(12), PDE6D(2), SLC6A13(10), TF(21) 23328549 267 123 265 89 83 48 29 61 45 1 0.193 1.000 1.000 373 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(7), ACAT2(9), ACOT11(9), ACYP1(2), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), FN3K(1), GCDH(8), HADHA(12), ITGB1BP3(1), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3) 17500620 214 122 190 71 53 43 28 51 38 1 0.407 1.000 1.000 374 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(27), IFNA1(8), IFNB1(6), IKBKB(9), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL1RN(7), IL6(7), IRAK1(6), IRAK2(11), IRAK3(11), JUN(2), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2), TOLLIP(5), TRAF6(4) 19825512 242 122 224 68 76 43 25 64 34 0 0.0748 1.000 1.000 375 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(12), DLG4(10), EPHB2(16), F2(10), F2RL1(8), F2RL2(8), JUN(2), MAP2K5(6), MAPK1(3), MAPK7(6), MAPK8(17), MYEF2(14), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RAF1(16), RASAL1(9), SRC(3), TEC(10), VAV1(24) 18732351 234 122 218 86 79 52 28 50 25 0 0.548 1.000 1.000 376 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(14), ACE2(15), AGT(12), AGTR1(14), AGTR2(17), ANPEP(19), CMA1(1), CPA3(5), CTSA(6), CTSG(5), ENPEP(24), LNPEP(23), MAS1(3), MME(27), NLN(13), REN(10), THOP1(6) 14399905 214 121 194 54 52 38 26 60 38 0 0.0172 1.000 1.000 377 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(81), EP300(56), ESR1(21), MAPK1(3), MAPK3(4), PELP1(11), SRC(3) 10143037 179 121 157 75 46 47 21 34 31 0 0.809 1.000 1.000 378 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(7), IL6R(8), JAK1(22), JAK2(55), JAK3(31), PIAS3(10), PTPRU(24), REG1A(8), SRC(3), STAT3(10) 10374426 180 121 148 66 56 57 23 21 19 4 0.556 1.000 1.000 379 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(14), AZIN1(3), BTG1(2), CBX3(7), CLOCK(24), CRY1(17), CRY2(5), DNAJA1(5), EIF4G2(16), ETV6(11), GFRA1(17), GSTM3(6), GSTP1(1), HERPUD1(3), HSPA8(13), IDI1(4), KLF9(1), MYF6(7), NCKAP1(17), NCOA4(9), NR1D2(10), PER1(13), PER2(9), PIGF(1), PPP1R3C(6), PPP2CB(4), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(8), TUBB3(10), UCP3(3), UGP2(12), VAPA(2), ZFR(21) 24979942 286 120 243 76 76 42 25 78 62 3 0.167 1.000 1.000 380 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(7), ARSB(10), FUCA1(7), FUCA2(5), GALNS(6), GBA(4), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE(11), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NAGLU(6), NEU1(6), NEU2(6), NEU3(2), SPAM1(13) 21886047 248 120 228 85 78 58 23 60 29 0 0.307 1.000 1.000 381 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(7), CDK7(3), ERCC3(19), GTF2A2(1), GTF2B(12), GTF2E1(13), GTF2E2(1), GTF2F2(1), GTF2H1(6), GTF2H4(3), ILK(3), MNAT1(4), POLR1A(15), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3B(14), POLR3D(5), POLR3E(13), POLR3H(2), POLR3K(2), TAF12(4), TAF13(3), TAF5(13), TAF6(9), TAF7(3), TAF9(3), TBP(2) 24399525 217 120 200 79 60 36 28 50 43 0 0.716 1.000 1.000 382 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(14), EPHA4(26), EPHB1(38), FYN(17), ITGA1(12), ITGB1(13), L1CAM(17), LYN(13), RAP1B(2), SELP(15) 10545769 167 118 153 56 52 34 31 31 18 1 0.135 1.000 1.000 383 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(12), ACO1(12), ACO2(7), CLYBL(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), OGDHL(16), PC(16), PCK1(6), PCK2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1) 19904306 187 118 175 68 61 25 27 49 25 0 0.506 1.000 1.000 384 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 33 ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(3), ENPP7(3), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(6), SGMS2(8), SGPP1(8), SGPP2(6), SMPD1(10), SMPD2(3), SMPD3(4), SMPD4(9), SPHK1(3), SPHK2(5), SPTLC1(12), SPTLC2(9), UGCG(9), UGT8(12) 21682977 235 118 223 87 72 41 34 53 34 1 0.443 1.000 1.000 385 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6) 16773466 208 117 185 76 44 50 26 57 30 1 0.632 1.000 1.000 386 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(13), FOS(5), GRB2(11), HRAS(4), IL3(6), JAK2(55), MAP2K1(12), MAPK3(4), PTPN6(4), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20) 11504029 190 117 150 60 46 63 17 29 31 4 0.421 1.000 1.000 387 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(10), BIRC2(7), BIRC3(18), CASP3(4), CASP8(20), CFLAR(3), FADD(1), IKBKG(2), JUN(2), MAP3K3(8), MAP3K7(9), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NR2C2(11), RALBP1(8), RIPK1(7), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8) 16764403 195 116 169 61 43 54 16 40 42 0 0.303 1.000 1.000 388 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(11), ADRBK2(11), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CLCA1(14), CLCA2(11), CLCA4(15), CNGA3(17), CNGA4(14), CNGB1(15), GNAL(5), GUCA1A(3), GUCA1B(4), GUCA1C(3), PDC(4), PDE1C(19), PRKACA(2), PRKACB(5), PRKACG(9), PRKG1(18), PRKG2(12), PRKX(3) 21422132 228 115 218 107 64 34 31 64 35 0 0.978 1.000 1.000 389 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(7), CS(2), DLAT(10), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), PC(16), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PDK1(7), PDK2(9), PDK3(6), PDK4(6), PDP2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1) 19541091 203 115 186 81 64 33 26 51 29 0 0.761 1.000 1.000 390 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(27), FADD(1), IKBKB(9), IKBKG(2), IL1A(1), IL1R1(7), IRAK1(6), MAP3K1(21), MAP3K14(6), MAP3K7(9), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TLR4(18), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4) 16109182 193 115 178 62 46 55 18 44 30 0 0.253 1.000 1.000 391 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), LTA(1), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNFAIP3(42), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12) 15452709 195 115 173 64 52 55 20 34 34 0 0.206 1.000 1.000 392 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(5), CSF1R(16), DDX20(7), E2F4(2), ETS1(10), ETS2(5), ETV3(5), FOS(5), HDAC2(8), HDAC5(14), HRAS(4), JUN(2), NCOR2(44), RBL1(21), RBL2(24), SIN3A(28), SIN3B(10) 17145408 210 114 183 80 55 41 20 42 52 0 0.872 1.000 1.000 393 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 IL10RA(4), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(22), JAK2(55), JAK3(31), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), TYK2(5) 12278247 182 114 148 65 38 62 14 34 30 4 0.803 1.000 1.000 394 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(24), CALM2(1), CALM3(1), CAPN2(10), CAPNS1(4), CAPNS2(4), EP300(56), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SYT1(14) 15300958 173 114 153 73 50 35 22 32 34 0 0.825 1.000 1.000 395 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(22), JAK2(55), JAK3(31), PIAS1(4), PIAS3(10), PTPRU(24), REG1A(8), SOAT1(6) 9167754 162 114 136 58 47 56 17 19 19 4 0.511 1.000 1.000 396 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(10), F2R(11), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), PLA2G4A(16), PLCB1(23), PRKCA(8), PTGS1(10), PTK2(24), RAF1(16), SRC(3), SYK(8), TBXAS1(13) 16933598 199 113 179 83 68 43 27 40 21 0 0.803 1.000 1.000 397 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(10), ABAT(8), ADSL(13), ADSS(8), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), CAD(23), CRAT(11), DARS(5), DDO(6), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), PC(16) 17503229 190 112 176 73 64 24 30 47 25 0 0.674 1.000 1.000 398 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(12), AKR1D1(9), ARSB(10), ARSD(9), ARSE(4), CYP11B1(17), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10) 18613178 201 112 182 55 69 30 23 39 40 0 0.0221 1.000 1.000 399 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(10), DYRK1B(14), GLI2(28), GLI3(44), GSK3B(17), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SHH(3), SMO(13), SUFU(5) 10475187 169 112 154 71 60 38 14 30 27 0 0.691 1.000 1.000 400 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(27), GNAS(39), GNB1(3), GNGT1(1), PPP2CA(3), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 10150157 159 111 134 47 68 31 8 31 21 0 0.118 1.000 1.000 401 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(13), ITGB3(16), PTK2(24), PXN(2), RAC1(2), SPTAN1(30), SRC(3), TLN1(23) 19208856 187 111 180 96 60 31 23 45 26 2 0.997 1.000 1.000 402 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C8B(23), C9(12), MASP1(23) 16668527 202 110 192 65 59 26 22 52 41 2 0.515 1.000 1.000 403 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(75), MAP2(60), PPP1CA(2), PPP2CA(3), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6), PRKCE(6) 12641543 175 109 151 56 36 40 23 39 37 0 0.395 1.000 1.000 404 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(11), CHIT1(12), CMAS(9), CTBS(6), CYB5R1(4), CYB5R3(2), GFPT1(6), GFPT2(12), GNE(8), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NAGK(7), NANS(2), NPL(4), PGM3(7), PHPT1(2), RENBP(3), UAP1(6) 19707803 200 109 191 56 74 36 24 38 28 0 0.0434 1.000 1.000 405 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(12), BAIAP2(7), CASP1(6), CASP3(4), CASP7(3), CASP8(20), GAPDH(2), INSR(21), ITCH(7), MAGI1(31), MAGI2(32), RERE(15), WWP1(21), WWP2(9) 16031074 190 109 176 70 53 31 28 38 39 1 0.659 1.000 1.000 406 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(12), EEA1(19), GRASP(3), GSK3A(6), GSK3B(17), LYN(13), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PLCG1(19), PRKCE(6), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(9), VAV2(20) 16443107 190 108 173 63 57 39 26 37 30 1 0.328 1.000 1.000 407 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(5), DAB1(16), FYN(17), LRP8(5), RELN(95), VLDLR(15) 9756132 156 107 129 50 41 38 17 39 21 0 0.116 1.000 1.000 408 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(27), ARHGDIB(5), BIRC2(7), BIRC3(18), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), GZMB(5), LMNA(1), LMNB1(11), LMNB2(3), PRF1(8) 13214043 162 106 135 55 30 36 14 44 38 0 0.763 1.000 1.000 409 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), TNFAIP3(42), TRAF3(12), TRAF6(4) 12705040 167 106 149 51 41 47 16 32 31 0 0.193 1.000 1.000 410 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(19), GTF2A1(6), GTF2B(12), GTF2E1(13), GTF2F1(7), HDAC3(3), NCOA1(15), NCOA2(23), NCOA3(21), NCOR2(44), POLR2A(14), RARA(6), RXRA(8), TBP(2) 16178934 193 106 169 85 59 29 29 37 39 0 0.975 1.000 1.000 411 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 23 ATF1(6), CASP2(8), CHUK(27), CRADD(4), IKBKB(9), IKBKG(2), JUN(2), LTA(1), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP4K2(6), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNF(2), TNFRSF1A(4), TRAF2(8) 15496295 184 106 168 63 53 43 19 42 27 0 0.375 1.000 1.000 412 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(10), CARS(11), DARS(5), EPRS(27), FARS2(7), GARS(8), HARS(6), IARS(10), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), NARS(5), QARS(14), RARS(9), SARS(6), TARS(10), WARS(4), WARS2(7), YARS(4) 22744531 192 105 186 44 58 26 28 52 28 0 0.0199 1.000 1.000 413 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12), MASP1(23), MASP2(10), MBL2(3) 17012866 192 104 183 67 54 22 21 51 42 2 0.740 1.000 1.000 414 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(1), BLVRA(2), BLVRB(2), CP(24), CPOX(4), EPRS(27), FECH(4), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UROD(3), UROS(5) 18782028 175 104 156 46 43 30 23 40 39 0 0.187 1.000 1.000 415 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 12 ARHGEF1(15), GNA12(7), GNA13(3), GNAQ(11), GNB1(3), GNGT1(1), MYL2(2), MYLK(33), PLCB1(23), PPP1R12B(33), PRKCA(8), ROCK1(35) 12436250 174 103 142 57 41 27 15 39 48 4 0.725 1.000 1.000 416 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), GCK(6), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), KHK(4), MPI(4), PFKFB1(14), PFKFB3(3), PFKFB4(5), PFKM(5), PFKP(16), PMM1(5), PMM2(2), SORD(2), TPI1(3) 16348521 170 102 157 61 64 24 16 45 21 0 0.450 1.000 1.000 417 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(16), ALDOC(3), DERA(4), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKL(7), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1(9), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TALDO1(4), TKT(7), TKTL1(8), TKTL2(15) 15779471 174 102 162 58 58 30 25 46 15 0 0.168 1.000 1.000 418 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(8), CARM1(3), CBS(4), CTH(6), GGT1(11), HEMK1(1), LCMT1(1), LCMT2(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), METTL2B(3), METTL6(8), PAPSS1(5), PAPSS2(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SCLY(12), SEPHS1(7), SEPHS2(5), WBSCR22(2) 16478016 167 102 156 51 42 27 23 41 34 0 0.196 1.000 1.000 419 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 16 CALM2(1), CALM3(1), CDKN1A(2), GNAQ(11), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SP1(7), SP3(13), SYT1(14) 13023936 138 101 124 59 43 33 13 25 24 0 0.839 1.000 1.000 420 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(8), AMD1(4), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTAP(3), MTFMT(1), MTR(14), SRM(1), TAT(16) 14116545 174 101 161 57 66 21 26 33 27 1 0.248 1.000 1.000 421 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 17 AADAC(7), ABP1(4), AOC2(12), AOC3(10), CES1(14), CES7(1), ESCO1(22), ESCO2(18), LIPA(3), MYST3(34), MYST4(33), NAT6(2), PLA1A(10), PNPLA3(6), PPME1(2), PRDX6(5), SH3GLB1(6) 16351661 189 101 172 72 50 35 24 49 30 1 0.702 1.000 1.000 422 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(44), APOA1(3), APOA4(6), APOC1(1), APOC2(2), APOE(1), CETP(12), CYP7A1(14), DGAT1(5), HMGCR(7), LCAT(4), LDLR(11), LIPC(6), LPL(12), LRP1(53), SCARB1(4), SOAT1(6) 18004821 191 101 181 71 65 30 25 48 23 0 0.546 1.000 1.000 423 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), HAL(12) 14785991 161 100 152 58 50 29 19 38 25 0 0.631 1.000 1.000 424 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(27), ADRB2(3), GNAS(39), PLCE1(34), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAP2B(3) 9500104 141 100 121 34 57 31 7 32 14 0 0.00902 1.000 1.000 425 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(22), JAK2(55), JAK3(31), MAPK1(3), MAPK3(4), STAT3(10), TYK2(5) 7857135 130 100 103 49 27 56 10 19 14 4 0.769 1.000 1.000 426 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(5), CSNK1D(15), DRD1(9), DRD2(9), GRM1(37), PLCB1(23), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6) 10797443 147 99 133 54 50 35 7 33 22 0 0.565 1.000 1.000 427 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(16), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPHN(18), NSF(4), SRC(3), UBQLN1(6) 8469740 155 99 140 47 40 22 17 51 25 0 0.205 1.000 1.000 428 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 27 ATG3(4), ATG5(10), ATG7(1), BECN1(3), GABARAPL1(1), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(29), PIK3R4(21), PRKAA1(9), PRKAA2(20), ULK2(14), ULK3(3) 13352843 166 99 146 48 26 42 23 51 23 1 0.206 1.000 1.000 429 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 19 BAD(1), BAX(16), BCL2(2), CASP8(20), CYCS(1), FADD(1), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFKB1(11), NSMAF(13), RAF1(16), RELA(10), RIPK1(7), SMPD1(10), TNFRSF1A(4), TRAF2(8) 13359013 177 98 151 49 54 30 19 34 39 1 0.107 1.000 1.000 430 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(27), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP7(3), CASP8(20), CASP9(6), DFFA(6), DFFB(2), GZMB(5), PRF1(8), SCAP(9), SREBF1(8), SREBF2(10) 11809219 140 98 120 47 28 25 16 38 33 0 0.596 1.000 1.000 431 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(12), ACO2(7), CS(2), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), PC(16), PCK1(6), SDHA(14), SDHB(3), SUCLA2(9), SUCLG1(3), SUCLG2(1) 13467799 128 96 119 52 38 19 18 34 19 0 0.745 1.000 1.000 432 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(5), ALOX5(12), CYP1A2(11), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), HSD3B7(3), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), RDH11(4), RDH12(7), RDH13(4), RDH14(1) 16709635 177 96 169 62 62 35 18 48 13 1 0.325 1.000 1.000 433 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(13), GLB1(9), HEXA(4), HEXB(5), LCT(46), SLC33A1(10), ST3GAL1(3), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10) 11266988 151 96 129 53 53 33 13 32 20 0 0.470 1.000 1.000 434 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME3(8), PGK1(3), PGK2(10), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TKTL1(8), TKTL2(15), TPI1(3) 13626489 150 96 140 58 45 22 17 49 17 0 0.667 1.000 1.000 435 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), DDOST(4), DPAGT1(14), DPM1(3), FUT8(11), MAN1A1(14), MAN1B1(7), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), RPN1(4), RPN2(7), ST6GAL1(3) 12685384 151 96 136 52 43 33 17 30 28 0 0.679 1.000 1.000 436 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL4(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR7(7), CD28(5), CD4(4), CXCR3(5), CXCR4(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18R1(16), IL2(5), IL4(5), IL4R(6), TGFB1(2), TGFB2(10), TGFB3(2) 14143712 159 96 145 62 34 37 21 45 21 1 0.641 1.000 1.000 437 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1(9), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TAL1(3), TALDO1(4), TKT(7) 13375468 143 96 130 47 47 26 17 41 12 0 0.216 1.000 1.000 438 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(7), CREBBP(81), DFFA(6), DFFB(2), GZMA(11), GZMB(5), HMGB2(2), NME1(1), PRF1(8), SET(6) 7165757 130 96 119 51 34 31 14 31 20 0 0.666 1.000 1.000 439 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(3), IFNGR1(8), JAK1(22), JAK2(55), PTPRU(24), REG1A(8), STAT1(17) 7960983 139 96 118 47 41 50 8 21 14 5 0.484 1.000 1.000 440 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(27), ADRB2(3), CFTR(21), GNAS(39), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SLC9A3R1(3) 8463733 128 95 108 35 51 27 6 29 15 0 0.0556 1.000 1.000 441 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 ABO(7), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GCNT2(26), ST3GAL6(16), ST8SIA1(10) 9215862 142 95 131 33 48 20 11 41 21 1 0.0228 1.000 1.000 442 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CCR5(11), CD2(7), CD3D(5), CD3E(2), CD4(4), CXCR3(5), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), JAK2(55), STAT4(13), TYK2(5) 10007909 138 95 117 55 17 56 19 32 11 3 0.770 1.000 1.000 443 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(10), SMPD2(3), SPTLC1(12), SPTLC2(9), UGCG(9) 15097703 165 94 155 62 50 30 22 43 20 0 0.538 1.000 1.000 444 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), XYLB(6) 17778277 187 94 169 46 33 30 23 55 46 0 0.143 1.000 1.000 445 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(11), GRB2(11), IL2RG(9), IL4(5), IL4R(6), IRS1(21), JAK1(22), JAK3(31), RPS6KB1(9), SHC1(14), STAT6(4) 9532244 143 94 112 37 34 32 17 21 37 2 0.177 1.000 1.000 446 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(4), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(7), EDN1(3), EDNRA(9), EDNRB(19), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(16), PRL(4), PTGDR(9), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13) 14267644 160 93 151 58 59 18 14 46 23 0 0.566 1.000 1.000 447 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(27), CREM(10), FHL5(11), FSHB(6), FSHR(19), GNAS(39), XPO1(9) 6175525 121 92 95 32 50 29 9 24 9 0 0.0841 1.000 1.000 448 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(11), F13A1(15), F2(10), F2R(11), FGA(23), FGB(6), FGG(7), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10) 9577865 148 92 137 52 41 26 25 33 23 0 0.490 1.000 1.000 449 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE(11), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), NAGLU(6), SPAM1(13) 13451262 166 92 148 54 52 37 15 43 19 0 0.279 1.000 1.000 450 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), GLCE(8), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), NDST1(10), NDST2(10), NDST3(19), NDST4(13) 13840841 152 92 147 57 58 29 13 34 18 0 0.646 1.000 1.000 451 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(1), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), ILVBL(9), PANK1(7), PANK2(1), PANK3(7), PANK4(8), PPCS(4), UPB1(9), VNN1(13) 11358523 151 92 141 46 32 29 28 44 17 1 0.132 1.000 1.000 452 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 22 CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), HDAC5(14), MEF2A(7), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(5), PPP3CB(11), PPP3CC(7), SLC2A4(8), SYT1(14), YWHAH(5) 13353528 150 92 142 70 48 32 11 33 26 0 0.952 1.000 1.000 453 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 AANAT(2), ACHE(5), CHAT(17), DBH(9), DDC(5), GAD1(17), GAD2(15), HDC(14), MAOA(7), PAH(17), PNMT(3), SLC18A3(12), TPH1(4) 9026307 127 90 119 54 42 19 12 44 10 0 0.746 1.000 1.000 454 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), JAK2(55), TYK2(5) 7151025 113 90 90 44 20 55 4 22 8 4 0.741 1.000 1.000 455 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), JAK2(55), TYK2(5) 7151025 113 90 90 44 20 55 4 22 8 4 0.741 1.000 1.000 456 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(7), CHUK(27), IFNG(3), IKBKB(9), IL2(5), IL4(5), JUN(2), MAP3K1(21), MAP3K5(16), MAP4K5(4), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), TNFRSF9(10), TRAF2(8) 13368999 164 89 147 40 44 41 16 44 19 0 0.0246 1.000 1.000 457 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PGK1(3), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TPI1(3) 12129487 126 89 116 46 35 20 15 40 16 0 0.548 1.000 1.000 458 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(19), CD2(7), CD33(3), CD5(9), CD7(6), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(18), TLR2(12), TLR4(18), TLR7(18), TLR9(16) 12701615 161 89 149 61 52 24 17 50 16 2 0.545 1.000 1.000 459 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2) 12938978 142 89 134 52 46 36 15 31 14 0 0.421 1.000 1.000 460 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(14), CLOCK(24), CRY1(17), CRY2(5), CSNK1D(15), CSNK1E(9), NPAS2(10), NR1D1(8), PER1(13), PER2(9), PER3(20) 11433966 144 89 116 31 45 29 10 33 25 2 0.00806 1.000 1.000 461 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(8), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTR(14) 11950916 149 89 139 46 57 20 19 27 25 1 0.207 1.000 1.000 462 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(22), AP2A1(5), AP2M1(6), BIN1(6), CALM2(1), CALM3(1), DNM1(16), EPN1(10), EPS15(14), NME1(1), PICALM(9), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYNJ1(28), SYNJ2(15), SYT1(14) 15355004 171 89 155 70 48 30 17 44 32 0 0.798 1.000 1.000 463 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 14 CHUK(27), MAP3K14(6), MAPK14(8), MAPK8(17), NFKB1(11), RELA(10), TNFRSF13B(7), TNFRSF17(4), TNFSF13(2), TNFSF13B(4), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4) 9700198 133 89 120 38 44 29 10 25 25 0 0.211 1.000 1.000 464 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(6), CR1(20), CR2(22), FCGR2B(2), HLA-DRB1(7), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36) 9581861 136 88 134 46 31 19 22 33 29 2 0.549 1.000 1.000 465 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AGPS(6), CHPT1(4), ENPP2(27), ENPP6(11), PAFAH1B1(6), PAFAH1B3(2), PAFAH2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PPAP2A(2), PPAP2B(2), PPAP2C(3) 16146603 163 88 153 72 57 30 21 37 18 0 0.931 1.000 1.000 466 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(27), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(7), BIRC3(18), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), DIABLO(3), ENDOG(3) 9412726 127 88 98 32 20 19 17 31 39 1 0.352 1.000 1.000 467 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), SELE(13), SELL(5), SELP(15) 10693526 129 88 131 44 41 21 13 31 23 0 0.374 1.000 1.000 468 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4) 9027693 125 87 109 34 29 31 19 31 15 0 0.0634 1.000 1.000 469 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6) 11082560 143 86 125 51 34 32 15 37 24 1 0.663 1.000 1.000 470 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(15), BST1(3), C9orf95(2), CD38(5), ENPP1(17), ENPP3(12), NADK(8), NADSYN1(4), NMNAT1(3), NMNAT2(5), NMNAT3(5), NNMT(6), NNT(8), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT12(3), QPRT(2) 15172522 146 86 139 52 45 27 17 36 20 1 0.362 1.000 1.000 471 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12) 14305523 156 85 147 50 44 16 16 39 39 2 0.659 1.000 1.000 472 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(4), GPLD1(16), PGAP1(14), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGW(2), PIGX(4), PIGZ(6) 16362410 139 84 130 57 24 30 13 44 28 0 0.933 1.000 1.000 473 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(25), ABCC2(23), ABCG2(17), CES1(14), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10) 15469541 155 84 137 54 44 27 20 35 28 1 0.428 1.000 1.000 474 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), HAL(12) 13277194 136 84 127 51 41 26 17 29 23 0 0.731 1.000 1.000 475 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), PON1(12), PON2(7), PON3(14) 11598072 139 83 126 46 37 31 14 34 21 2 0.351 1.000 1.000 476 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(7), CAT(8), EPX(14), LPO(10), MPO(17), MTHFR(9), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36) 7671411 118 83 106 32 54 14 13 21 16 0 0.0871 1.000 1.000 477 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(7), ATP6V0C(1), CAT(8), EPX(14), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36) 7751352 117 83 105 34 55 14 13 18 17 0 0.106 1.000 1.000 478 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(7), FOS(5), GNAQ(11), JUN(2), MAPK14(8), MAPK8(17), PLCG1(19), PRKCA(8), PTK2B(13), SYT1(14) 9455777 120 82 108 51 26 31 9 36 18 0 0.944 1.000 1.000 479 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(16), JAK2(55), NFKB1(11), NFKBIA(1), RELA(10), SOD2(4) 8654048 116 82 100 47 24 44 13 17 15 3 0.727 1.000 1.000 480 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(13), ERBB4(65), NRG2(8), NRG3(18), PRKCA(8), PSEN1(4) 6360313 116 82 106 39 23 22 20 34 17 0 0.448 1.000 1.000 481 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(10), F2R(11), F3(2), F5(37), F7(7), FGA(23), FGB(6), FGG(7), PROC(3), PROS1(12), SERPINC1(8), TFPI(9) 11211396 140 82 131 54 37 29 20 38 16 0 0.723 1.000 1.000 482 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(6), ALDH18A1(8), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), GAMT(6), GATM(2), GLUD1(4), NAGS(6), OAT(4), ODC1(8), OTC(17), SMS(4) 11898702 137 81 127 38 39 29 19 33 17 0 0.0859 1.000 1.000 483 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(3), IFNGR1(8), IFNGR2(5), JAK1(22), JAK2(55), STAT1(17) 5876778 110 80 91 40 22 47 4 21 11 5 0.632 1.000 1.000 484 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(6), ACADM(12), ACADS(4), ACADVL(6), ACSL1(9), ACSL3(12), ACSL4(10), CPT1A(13), CPT2(3), DCI(4), EHHADH(15), HADHA(12), SCP2(6), SLC25A20(2) 11733185 114 80 103 44 29 21 15 31 18 0 0.588 1.000 1.000 485 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2) 10562813 122 80 115 37 37 31 14 26 14 0 0.145 1.000 1.000 486 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), PANK1(7), PANK2(1), PANK3(7), PANK4(8), PPCS(4), UPB1(9) 9038743 128 80 119 35 22 25 24 39 17 1 0.0833 1.000 1.000 487 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), FDXR(5), SHMT1(7) 11185039 120 79 102 41 34 28 15 24 19 0 0.499 1.000 1.000 488 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), NCK1(1), NCKAP1(17), NTRK1(17), PIR(2), PSMA7(2), RAC1(2), WASF1(6), WASF2(5), WASF3(17), WASL(18) 10790657 130 78 123 44 36 16 19 36 23 0 0.488 1.000 1.000 489 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7) 10716841 115 78 97 40 33 27 15 22 18 0 0.538 1.000 1.000 490 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(11), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK1(3), MAPK3(4), MYC(5), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RAF1(16), RELA(10), TNF(2) 10407445 117 78 106 48 39 21 19 22 16 0 0.658 1.000 1.000 491 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7) 10716841 115 78 97 40 33 27 15 22 18 0 0.538 1.000 1.000 492 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(14), APAF1(27), BCL2(2), CASP3(4), CASP9(6), CYCS(1), DAXX(18), FAS(9), FASLG(3), HSPB2(3), IL1A(1), MAPKAPK2(5), MAPKAPK3(6), TNF(2) 7422406 101 78 81 37 18 30 13 17 23 0 0.755 1.000 1.000 493 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(36), CPT1A(13), LEP(1), LEPR(21), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7) 10370628 122 78 115 36 38 14 12 39 19 0 0.407 1.000 1.000 494 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(35), ABCB11(19), ABCB4(28), ABCC1(25), ABCC3(11), GSTP1(1) 9746347 119 78 123 37 23 20 18 32 24 2 0.409 1.000 1.000 495 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7) 10716841 115 78 97 40 33 27 15 22 18 0 0.538 1.000 1.000 496 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(39), GNB1(3), GNGT1(1), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8) 6294507 90 77 73 33 39 21 2 16 12 0 0.475 1.000 1.000 497 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), CHST1(10), CHST2(13), CHST4(8), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 7278265 103 77 101 36 51 17 4 17 14 0 0.596 1.000 1.000 498 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(27), BAD(1), BAK1(2), BAX(16), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), CASP8AP2(30), CASP9(6), CES1(14) 7117379 113 77 92 31 21 10 19 23 38 2 0.650 1.000 1.000 499 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(27), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(4), CASP8(20), CASP9(6), CYCS(1), GZMB(5), JUN(2), PRF1(8) 6864885 91 76 75 32 17 19 9 20 26 0 0.742 1.000 1.000 500 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(25), C5(25), C6(27), C7(11), C8A(14), C9(12) 8778922 114 75 107 35 35 11 13 30 24 1 0.385 1.000 1.000 501 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(4), ALOX15(5), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(3), GGT1(11), LTA4H(2), PLA2G6(10), PTGDS(2), PTGES(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13) 9867332 102 75 94 37 34 11 12 22 23 0 0.596 1.000 1.000 502 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(1), IARS(10), IARS2(19), ILVBL(9), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3), VARS(7), VARS2(9) 11405023 107 75 105 41 42 17 14 19 15 0 0.723 1.000 1.000 503 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 64 FAU(2), MRPL13(8), MRPS7(4), RPL10A(3), RPL10L(4), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(4), RPL7(4), RPL8(3), RPL9(4), RPS10(2), RPS11(2), RPS13(2), RPS15A(1), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS5(2), RPS6(3), RPS7(1), RPS9(3), RPSA(1) 13694342 122 75 117 32 29 27 20 31 15 0 0.152 1.000 1.000 504 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2) 16195591 124 75 119 31 38 17 25 27 17 0 0.0476 1.000 1.000 505 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(24), CLTA(6), CLTB(3), COPA(14), GBF1(19), GPLD1(16), KDELR1(5), KDELR2(9), KDELR3(2) 11408612 110 74 106 39 31 21 14 22 22 0 0.652 1.000 1.000 506 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), PHPT1(2), RFK(1), TYR(12) 10560919 120 74 107 38 35 30 14 22 17 2 0.292 1.000 1.000 507 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(13), KHK(4), LCT(46), MPI(4), PGM1(10), PYGL(8), PYGM(12), TPI1(3), TREH(6) 9210110 106 73 98 34 34 22 15 28 7 0 0.170 1.000 1.000 508 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), IDS(5), LCT(46), NAGLU(6) 9533781 106 73 97 37 39 21 10 25 11 0 0.315 1.000 1.000 509 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELE(13), SELL(5) 8270708 100 73 98 38 27 17 9 26 21 0 0.696 1.000 1.000 510 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42) 11478171 122 71 108 39 37 15 21 31 18 0 0.356 1.000 1.000 511 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(21), ESR2(8), ITPKA(3), PDE1A(10), PDE1B(11), PLCB1(23), PLCB2(11), PRL(4), TRH(8), VIP(3) 7534369 102 71 94 39 28 19 15 24 16 0 0.677 1.000 1.000 512 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 CD28(5), CD3D(5), CD3E(2), IFNG(3), IL2(5), IL2RA(6), IL4(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), TOB1(8), TOB2(2) 7211875 118 71 102 39 37 29 13 23 16 0 0.297 1.000 1.000 513 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(9), CYB5R3(2), GCK(6), GFPT1(6), GNE(8), GNPDA1(2), GNPDA2(3), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), PGM3(7), RENBP(3), UAP1(6) 11659061 103 70 97 31 35 24 12 19 13 0 0.192 1.000 1.000 514 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(13), AMT(2), ATIC(14), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6) 12911227 107 70 101 51 33 17 16 22 17 2 0.944 1.000 1.000 515 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(4), CSF1(5), CSF3(3), HLA-DRB1(7), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL11(6), IL12A(2), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), LTA(1), PDGFA(2), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2) 8684335 103 70 93 45 30 18 9 29 14 3 0.887 1.000 1.000 516 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(7), CS(2), FH(10), IDH2(17), MDH1(8), OGDH(14), SDHA(14), SUCLA2(9) 6549626 81 69 71 29 22 15 8 22 14 0 0.581 1.000 1.000 517 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(7), IFNB1(6), JAK1(22), PTPRU(24), REG1A(8), STAT1(17), STAT2(12), TYK2(5) 8526878 101 69 92 27 39 21 8 18 14 1 0.133 1.000 1.000 518 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(14), EIF2AK4(23), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF5(6), GSK3B(17), PPP1CA(2) 7874754 85 68 72 21 14 31 6 15 19 0 0.136 1.000 1.000 519 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(9), CYSLTR2(18), GPR109B(5), GPR161(13), GPR171(11), GPR18(5), GPR34(11), GPR39(4), GPR45(14), GPR65(2), GPR68(5), GPR75(10) 6794550 107 68 93 44 30 21 7 29 19 1 0.841 1.000 1.000 520 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(6), B3GAT2(1), B3GAT3(2), B4GALT7(2), CHPF(10), CHST11(6), CHST12(6), CHST14(1), CHST3(7), CHSY1(14), DSE(10), UST(12), XYLT1(14), XYLT2(15) 8544270 106 68 88 51 41 16 12 18 18 1 0.953 1.000 1.000 521 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(2), BNIP1(5), GOSR1(5), GOSR2(6), SEC22B(3), SNAP23(2), SNAP25(2), SNAP29(4), STX11(7), STX12(6), STX16(7), STX17(2), STX18(3), STX19(4), STX2(6), STX3(4), STX4(3), STX5(11), STX6(2), STX7(4), STX8(7), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(4), VAMP4(4), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1), YKT6(1) 11075338 124 68 111 35 39 12 11 29 33 0 0.381 1.000 1.000 522 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(5), CD86(2), HLA-DRB1(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), IL2(5), IL2RA(6), IL4(5), IL4R(6) 8376012 99 68 89 32 23 19 14 24 16 3 0.324 1.000 1.000 523 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2) 9410902 88 67 89 34 19 21 9 26 13 0 0.734 1.000 1.000 524 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(4), GALNT10(8), GALNT2(15), GALNT3(15), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GCNT1(9), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4) 9088904 93 67 91 39 35 18 14 12 14 0 0.737 1.000 1.000 525 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(13), AMT(2), ATIC(14), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6) 12541796 102 67 94 49 30 18 15 21 16 2 0.941 1.000 1.000 526 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(6), FDFT1(4), FDPS(6), GGCX(11), GGPS1(5), HMGCR(7), IDI1(4), IDI2(3), LSS(5), MVD(3), MVK(16), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2), TM7SF2(2) 12916653 108 66 97 41 33 8 14 28 25 0 0.891 1.000 1.000 527 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(19), PSMD11(8), PSMD12(6), PSMD13(8), PSMD2(4), PSMD6(8) 11487542 97 66 88 37 25 24 11 25 12 0 0.728 1.000 1.000 528 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10) 11835122 102 66 88 30 27 14 13 18 30 0 0.450 1.000 1.000 529 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(7), CD28(5), CD3D(5), CD3E(2), CD4(4), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36) 7473398 102 66 96 41 25 16 15 23 23 0 0.782 1.000 1.000 530 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(19), CKM(7), FBL(6), GPT(7), LDHA(14), LDHB(8), LDHC(4), MAPK14(8), NCL(12) 6045227 85 65 74 33 21 21 12 24 7 0 0.641 1.000 1.000 531 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(7), CD28(5), CD3D(5), CD3E(2), CD8A(2), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36) 7012128 100 65 94 39 27 16 13 22 22 0 0.712 1.000 1.000 532 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(3), EPO(1), FLT3(36), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(7), IL9(2), KITLG(3), TGFB1(2), TGFB2(10), TGFB3(2) 5817287 85 64 75 40 21 21 7 23 12 1 0.940 1.000 1.000 533 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), NTAN1(10), SIRT1(8), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(5) 8175711 78 63 68 26 22 11 10 14 21 0 0.547 1.000 1.000 534 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(6), ICAM1(4), ITGAL(21), ITGAM(14), ITGB2(18), SELE(13), SELL(5) 6781644 81 63 87 27 30 12 8 16 15 0 0.363 1.000 1.000 535 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), NAT1(1), NAT2(3), XDH(19) 5673381 77 62 72 34 25 13 10 21 8 0 0.858 1.000 1.000 536 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PCYT1A(5), PCYT1B(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2) 9317773 82 62 85 36 19 18 9 23 13 0 0.915 1.000 1.000 537 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(2), HMOX1(6), IL10(2), IL10RA(4), IL10RB(7), IL1A(1), IL6(7), JAK1(22), STAT1(17), STAT3(10), STAT5A(10), TNF(2) 8331374 92 62 80 35 30 16 6 22 17 1 0.735 1.000 1.000 538 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CAMKK1(2), CAMKK2(9), CREB1(3), SYT1(14) 7873843 82 61 74 39 21 21 9 17 14 0 0.929 1.000 1.000 539 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), IMPA2(4), ISYNA1(6), PGM1(10), PGM3(7), TGDS(1) 7573819 80 61 75 33 33 12 8 18 9 0 0.607 1.000 1.000 540 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(8), IFNAR1(7), IFNAR2(4), IFNB1(6), JAK1(22), STAT1(17), STAT2(12), TYK2(5) 7400082 81 61 70 24 22 18 6 21 13 1 0.355 1.000 1.000 541 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(13), ADSS(8), DHFR(1), HPRT1(2), IMPDH1(4), MTHFD2(2), POLB(6), POLD1(20), POLG(9), PRPS2(6), RRM1(3), SRM(1) 8300600 75 61 74 31 28 7 12 14 14 0 0.783 1.000 1.000 542 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(4), CASP7(3), DFFA(6), DFFB(2), ENDOG(3), GZMB(5), HMGB1(2), HMGB2(2), TOP2A(24), TOP2B(25) 6083306 76 60 71 18 10 15 8 22 21 0 0.439 1.000 1.000 543 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(14), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(3), CDK5R1(5), CSNK1A1(3), CSNK1D(15), GSK3B(17), MAPT(11), PPP2CA(3) 5698340 81 60 77 27 29 20 5 17 10 0 0.413 1.000 1.000 544 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 AKR1C4(12), AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4) 5644014 73 59 67 28 32 12 6 14 9 0 0.589 1.000 1.000 545 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL15(1), IL16(18), IL18(3), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL8(6), IL9(2), LTA(1), TNF(2) 6679783 81 59 72 43 23 16 8 25 9 0 0.954 1.000 1.000 546 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 10 AKR1C4(12), AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4) 5644014 73 59 67 28 32 12 6 14 9 0 0.589 1.000 1.000 547 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(12), ACO2(7), AFMID(3), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2) 9484795 83 59 76 26 25 10 13 24 11 0 0.242 1.000 1.000 548 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(15), CD38(5), ENPP1(17), ENPP3(12), NADSYN1(4), NMNAT1(3), NMNAT2(5), NNMT(6), NNT(8), NT5C(1), NT5E(7), NT5M(3), QPRT(2) 10368086 88 59 81 32 24 19 10 22 12 1 0.425 1.000 1.000 549 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(14), CD44(6), CSF1(5), FCGR3A(5), IL1B(5), IL6R(8), SELL(5), SPN(6), TGFB1(2), TGFB2(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(8), TNFSF8(6) 8798591 87 59 89 29 26 12 16 19 14 0 0.272 1.000 1.000 550 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(18), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(3), CDK2(5), CDK4(4), CDKN1B(6), CDKN2A(9), E2F2(7), E2F4(2), PRB1(5) 5854733 71 59 67 30 15 14 9 19 14 0 0.783 1.000 1.000 551 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(12), ACO2(7), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2) 9047504 80 58 73 24 24 10 13 22 11 0 0.201 1.000 1.000 552 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(5), FOSL1(1), FOSL2(5), IFNAR1(7), IFNAR2(4), IFNB1(6), MAPK8(17), NFKB1(11), RELA(10), TNFRSF11A(6), TNFSF11(8), TRAF6(4) 7427319 84 58 82 32 25 17 9 18 15 0 0.615 1.000 1.000 553 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(11), NEK1(20), WEE1(15) 4831657 73 58 64 26 11 19 5 19 18 1 0.833 1.000 1.000 554 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CSK(5), GRB2(11), PRKCA(8), PTPRA(6), SRC(3) 6378948 69 58 64 25 17 20 7 20 5 0 0.476 1.000 1.000 555 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(16), ENO1(3), GPI(6), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(12), TPI1(3) 5847539 67 57 59 29 22 13 5 20 7 0 0.833 1.000 1.000 556 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(6), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10) 6419614 77 56 76 26 24 10 8 23 12 0 0.514 1.000 1.000 557 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(6), B3GALNT1(6), B3GALT5(5), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST8SIA1(10) 6872877 84 56 81 28 30 10 9 23 12 0 0.434 1.000 1.000 558 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(7), UBE2A(5), UBE3A(25) 9226684 84 56 82 30 21 17 11 23 12 0 0.570 1.000 1.000 559 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(11), GNB1(3), GNGT1(1), HTR2C(15), PLCB1(23), TUB(14) 4961287 71 56 70 30 27 13 7 18 6 0 0.764 1.000 1.000 560 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 7 CD3D(5), CD3E(2), GZMB(5), ICAM1(4), ITGAL(21), ITGB2(18), PRF1(8) 4795831 63 55 58 28 27 9 3 9 15 0 0.805 1.000 1.000 561 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(5), GSR(5), GSS(9), IL8(6), NFKB1(11), NOX1(4), RELA(10), TNF(2), XDH(19) 6903227 71 55 66 23 17 22 7 11 14 0 0.457 1.000 1.000 562 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(8), ME1(14), PC(16), PDHA1(8), SLC25A1(1), SLC25A11(2) 6057386 63 55 57 21 23 15 7 11 7 0 0.344 1.000 1.000 563 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(9), CAMK1G(7), HDAC9(20), MEF2A(7), MEF2C(15), MEF2D(3), YWHAH(5) 4818752 66 55 74 32 21 9 3 22 10 1 0.956 1.000 1.000 564 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(5), MAX(5), MYC(5), SP1(7), SP3(13), WT1(32) 4179137 67 55 57 30 14 22 15 9 7 0 0.691 1.000 1.000 565 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(5), CHAT(17), CHKA(6), PCYT1A(5), PDHA1(8), PDHA2(17), PEMT(2), SLC18A3(12) 4591510 72 54 70 43 30 9 10 18 5 0 0.968 1.000 1.000 566 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(7), FARSA(6), FARSB(12), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4), YARS2(7) 6150246 78 53 71 25 19 8 12 27 12 0 0.474 1.000 1.000 567 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4) 5223575 64 53 59 19 26 14 3 12 9 0 0.439 1.000 1.000 568 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), PGM1(10), PGM3(7), TGDS(1) 6907599 70 53 65 29 28 11 7 17 7 0 0.652 1.000 1.000 569 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(28), GNA12(7), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6) 7123468 64 52 60 17 17 10 7 17 13 0 0.286 1.000 1.000 570 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(7), B3GALT1(3), B3GALT2(10), B3GALT5(5), B3GNT5(3), FUT1(11), FUT2(7), FUT3(6), ST3GAL3(12), ST3GAL4(4) 4700899 68 52 64 25 31 7 4 15 11 0 0.675 1.000 1.000 571 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(11), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10) 5746565 64 52 61 28 21 12 7 15 9 0 0.840 1.000 1.000 572 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 13 POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14) 8476258 73 51 71 20 26 13 8 16 10 0 0.273 1.000 1.000 573 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), IDI1(4), LSS(5), MVD(3), MVK(16), NQO1(1), NQO2(3), PMVK(2), SC5DL(9), SQLE(2) 7185377 66 50 56 20 20 8 8 15 15 0 0.436 1.000 1.000 574 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), RFK(1), TYR(12) 6843528 74 49 65 20 20 19 9 15 9 2 0.146 1.000 1.000 575 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), CCND1(2), CDK2(5), CDK4(4), CDKN1A(2), CDKN1B(6), CDKN2A(9), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(5) 4661823 59 49 55 21 10 14 8 11 16 0 0.632 1.000 1.000 576 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(3), ENO3(6), FARS2(7), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4) 5934868 65 48 59 28 15 7 14 20 9 0 0.857 1.000 1.000 577 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(5), UBE2A(5), UBE2B(3), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(4), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(25) 7020427 74 48 72 22 20 13 6 17 18 0 0.275 1.000 1.000 578 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), HMGCS1(1), IDI1(4), LSS(5), MVD(3), MVK(16), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2) 8736823 71 47 62 23 21 7 8 18 17 0 0.639 1.000 1.000 579 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(4), ECHS1(4), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), MECR(4), PPT1(1), PPT2(5) 5881095 54 47 53 18 14 9 6 13 12 0 0.456 1.000 1.000 580 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(10), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3) 7048795 62 46 61 27 20 11 9 14 8 0 0.859 1.000 1.000 581 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(15), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(6), APOBEC3F(2), APOBEC3G(8), APOBEC4(9) 5191508 57 44 56 17 22 5 10 10 10 0 0.312 1.000 1.000 582 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14), XYLT2(15) 3963660 51 43 39 24 19 7 2 8 14 1 0.974 1.000 1.000 583 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14), XYLT2(15) 3963660 51 43 39 24 19 7 2 8 14 1 0.974 1.000 1.000 584 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 11 CD2(7), CD34(7), CD3D(5), CD3E(2), CD4(4), CD8A(2), CSF3(3), IL3(6), IL6(7), IL8(6), KITLG(3) 3875790 52 43 44 23 12 14 5 13 8 0 0.748 1.000 1.000 585 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3) 4996405 57 43 55 15 17 6 5 10 19 0 0.269 1.000 1.000 586 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(5), CPS1(39), GLS(2), GLUD1(4), GOT1(7) 5422364 59 43 52 16 14 14 10 14 7 0 0.214 1.000 1.000 587 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 10 CREB1(3), FOS(5), JUN(2), KEAP1(5), MAPK1(3), MAPK14(8), MAPK8(17), NFE2L2(7), PRKCA(8) 5625930 58 42 57 24 13 12 5 20 8 0 0.803 1.000 1.000 588 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(11), MBTPS1(14), MBTPS2(2), SCAP(9), SREBF1(8), SREBF2(10) 7338535 55 42 54 28 16 13 8 10 8 0 0.839 1.000 1.000 589 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 13 BPNT1(9), CHST11(6), CHST12(6), PAPSS1(5), PAPSS2(7), SULT1A1(4), SULT1A2(4), SULT1E1(6), SULT2A1(6), SULT2B1(4), SUOX(5) 6526346 62 41 58 21 20 9 5 20 8 0 0.560 1.000 1.000 590 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(4), CD36(3), FOS(5), FYN(17), JUN(2), MAPK14(8), THBS1(14) 5017622 53 41 48 20 14 9 6 11 13 0 0.587 1.000 1.000 591 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(12), AOC3(10), CES1(14), ESD(5) 4004121 45 39 44 23 15 6 8 11 5 0 0.869 1.000 1.000 592 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(7), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), ST3GAL3(12) 2690635 48 39 45 19 26 5 3 9 5 0 0.593 1.000 1.000 593 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(7), SEC61A2(4), SRP19(1), SRP54(4), SRP68(13), SRP72(9), SRPR(13) 5300023 51 39 42 13 11 7 7 13 13 0 0.471 1.000 1.000 594 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(8), PLCG1(19), PRKCA(8), PTK2B(13) 4596991 48 39 44 26 15 12 6 9 6 0 0.967 1.000 1.000 595 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(8), F13B(12), HSD17B1(2), HSD17B2(7), HSD17B3(6), HSD17B4(9), HSD3B1(6), HSD3B2(4) 5650953 54 39 52 23 18 10 7 13 6 0 0.646 1.000 1.000 596 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 5 DBH(9), GAD1(17), HDC(14), PNMT(3), TPH1(4) 3543730 47 38 45 19 14 7 3 18 5 0 0.718 1.000 1.000 597 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(11), CYP2E1(11), NR1I3(5), PTGS1(10), PTGS2(10) 3714878 47 37 47 19 22 4 8 9 4 0 0.722 1.000 1.000 598 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(10), CYP11A1(7), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4) 4653077 45 37 43 26 18 7 7 7 6 0 0.916 1.000 1.000 599 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(11), NR1H3(16), NR1H4(9), RXRA(8) 3464000 46 36 39 21 14 9 6 6 11 0 0.904 1.000 1.000 600 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(1), ALAS1(12), ALAS2(12), CPOX(4), FECH(4), HMBS(5), PPOX(5), UROD(3), UROS(5) 5397606 51 36 47 13 21 8 5 11 6 0 0.344 1.000 1.000 601 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(6), ACADM(12), ACADS(4), ACAT1(7), ECHS1(4), HADHA(12) 3709116 45 35 43 19 12 6 6 8 13 0 0.746 1.000 1.000 602 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(7), GOT2(2), TAT(16), TYR(12) 3360193 42 35 34 22 11 6 11 11 3 0 0.911 1.000 1.000 603 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMB8(9), PSMB9(4) 5875820 44 35 43 19 9 5 5 17 8 0 0.855 1.000 1.000 604 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(7), ACAT2(9), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(1), HMGCS2(6), OXCT1(3), OXCT2(3) 5121005 36 33 34 14 13 6 3 7 7 0 0.701 1.000 1.000 605 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(7), CSF1(5), IL6(7), LDLR(11), LPL(12) 3651205 42 33 39 19 14 12 3 7 6 0 0.692 1.000 1.000 606 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(12), NR3C1(11), PPARG(4), RETN(2), RXRA(8), TNF(2) 3753014 41 33 37 25 10 8 8 8 7 0 0.970 1.000 1.000 607 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), DHFR(1), FPGS(4), GGH(2), SPR(7) 3636482 37 32 37 15 12 7 5 9 4 0 0.609 1.000 1.000 608 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(6), PLCD1(10), PRKCA(8), TGM2(17) 3400591 41 31 40 21 17 6 3 12 3 0 0.853 1.000 1.000 609 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(5), IL1B(5), MST1(5), MST1R(14), TNF(2) 3518329 31 28 28 11 11 5 4 8 3 0 0.496 1.000 1.000 610 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(2), CCR3(11), HLA-DRB1(7), IL3(6) 1585747 26 25 21 12 5 9 0 7 3 2 0.937 1.000 1.000 611 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(8), ARG1(2), GLS(2), GLUD1(4), OAT(4), PRODH(5) 3682869 25 23 24 12 11 7 2 1 4 0 0.760 1.000 1.000 612 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(12), SNAP25(2), STX1A(4), VAMP2(1) 2245011 23 23 20 11 7 6 3 6 1 0 0.907 1.000 1.000 613 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(7), GOT2(2), TAT(16) 1889276 25 21 19 13 7 1 9 5 3 0 0.867 1.000 1.000 614 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(7), ACAT2(9), HMGCL(1), OXCT1(3) 2416096 20 18 18 10 3 5 3 5 4 0 0.890 1.000 1.000 615 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(6), IFNG(3), IL12A(2), IL12B(1), IL18(3), IL2(5) 2128698 20 15 19 16 1 4 6 7 2 0 0.995 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 365947 1 1 1 2 1 0 0 0 0 0 0.955 1.000 1.000