rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(2), CDK2(5), CDK4(4), CDKN1A(2), CDKN1B(6), CDKN2A(9), CFL1(2), E2F2(7), MDM2(11), NXT1(5), PRB1(5), TP53(435)	5266161	494	339	277	99	140	106	56	85	103	4	1.13e-08	<1.00e-15	<6.16e-13
2	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(27), DNAJC3(4), EIF2S1(3), EIF2S2(2), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), TP53(435)	6724417	499	337	280	92	151	110	54	83	97	4	6.07e-10	3.55e-15	1.09e-12
3	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(5), MAX(5), MYC(5), SP1(7), SP3(13), TP53(435), WT1(32)	4783475	502	339	279	108	144	114	63	83	94	4	3.54e-09	5.66e-15	1.16e-12
4	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(5), CD3E(2), CD3G(16)	845905	23	21	8	3	1	5	2	0	15	0	0.457	0.0456	1.000
5	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(11)	513817	11	11	11	1	9	0	1	1	0	0	0.107	0.152	1.000
6	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(9), LIPT1(13)	1090040	22	19	17	1	0	3	2	6	11	0	0.132	0.217	1.000
7	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(27), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), FADD(1), FAS(9), FASLG(3), GZMB(5), IKBKG(2), JUN(2), MAP2K4(36), MAP3K1(21), MAP3K14(6), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), PARP1(17), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFSF10(3), TP53(435), TRAF1(7), TRAF2(8)	24988324	753	380	494	173	201	152	89	140	165	6	2.85e-08	0.620	1.000
8	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(2), ALDOB(16), ALDOC(3), TPI1(3)	2558746	30	28	26	3	6	6	2	15	1	0	0.0266	0.677	1.000
9	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(17), BMPR1A(18), BMPR1B(15), BMPR2(49)	4293349	99	71	82	16	21	16	5	21	26	10	0.0388	0.689	1.000
10	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(3)	1063963	9	9	9	1	0	1	1	7	0	0	0.306	0.788	1.000
11	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(11), CD28(5), CD3D(5), CD3E(2), CD3G(16), CD4(4)	2370618	43	35	27	8	5	5	6	8	19	0	0.322	0.821	1.000
12	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(5), CD4(4), HLA-DRA(12), HLA-DRB1(7)	1376679	28	25	27	8	6	4	3	7	5	3	0.594	0.823	1.000
13	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPX1(5), PRKCE(6)	5195954	119	86	107	26	31	17	14	40	17	0	0.00673	0.898	1.000
14	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(12), ALDH1A2(17), BCMO1(5), RDH5(2)	2727712	36	33	35	8	10	8	5	9	4	0	0.117	0.956	1.000
15	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), GSTZ1(5), HGD(6)	1586183	15	13	14	4	1	3	5	4	2	0	0.278	0.962	1.000
16	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(3), CDO1(3), CSAD(6), GAD1(17), GAD2(15), GGT1(11)	3850754	55	48	40	11	18	6	7	11	13	0	0.0786	0.978	1.000
17	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4)	5488463	93	66	81	13	29	20	13	21	10	0	0.000189	0.979	1.000
18	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4)	5488463	93	66	81	13	29	20	13	21	10	0	0.000189	0.979	1.000
19	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(4), CASP8(20), CFL1(2), CFLAR(3), PDE6D(2)	2623925	33	30	31	5	5	3	4	8	13	0	0.130	0.980	1.000
20	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), IL8(6), SLPI(2)	1095078	17	16	16	7	2	3	2	4	6	0	0.766	0.985	1.000
21	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GBA3(3), GGT1(11), SHMT1(7), SHMT2(5)	2503588	27	27	23	8	6	1	3	3	14	0	0.734	0.992	1.000
22	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(5), HLCS(14), SPCS1(3), SPCS3(2)	2144483	24	21	22	6	9	3	2	7	3	0	0.201	0.997	1.000
23	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(8), DCN(9), FMOD(8), KERA(9), LUM(14)	2495158	48	41	45	12	13	13	1	17	4	0	0.297	0.998	1.000
24	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), SDS(3)	8385086	127	87	111	22	37	25	20	27	18	0	0.000222	0.999	1.000
25	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(7), B3GNT1(5), FUT1(11), FUT2(7), FUT9(10), GCNT2(26), ST8SIA1(10)	3829261	76	59	70	20	24	8	9	23	11	1	0.0900	0.999	1.000
26	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(12), CYP2C9(11)	1451222	23	21	22	5	3	8	2	9	1	0	0.292	0.999	1.000
27	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), MIOX(3), UGDH(9)	5672987	84	62	71	15	22	18	12	16	16	0	0.0117	0.999	1.000
28	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(3), FOSB(6), GRIA2(29), PPP1R1B(1)	2306760	39	34	38	13	15	6	4	11	3	0	0.311	1.000	1.000
29	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(12), AGTR1(14), AGTR2(17), BDKRB2(6), KNG1(9), NOS3(23), REN(10)	6037396	105	68	90	20	30	9	11	29	26	0	0.0125	1.000	1.000
30	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(7), CD34(7), CD3D(5), CD3E(2), CD3G(16), CD4(4), CD58(15), CD8A(2), CSF3(3), IL3(6), IL6(7), IL8(6), KITLG(3)	4492788	83	56	61	23	13	16	6	17	30	1	0.518	1.000	1.000
31	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(5), CD3E(2), CD3G(16), CD4(4), FYN(17), HLA-DRA(12), HLA-DRB1(7), LCK(9), PTPRC(36), ZAP70(12)	6041686	120	84	95	29	26	23	16	18	34	3	0.0959	1.000	1.000
32	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(4), GALT(3), TGDS(1), UGDH(9), UGP2(12), UXS1(9)	3429686	38	33	39	7	8	2	6	11	11	0	0.281	1.000	1.000
33	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(10), BIRC3(18), CASP8(20), FADD(1), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	5215492	71	56	57	16	12	18	5	14	22	0	0.0851	1.000	1.000
34	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH1(21), IDH2(17), MGST1(2), MGST2(2), MGST3(1), PGD(7)	12505771	189	121	162	34	39	40	28	54	28	0	0.000118	1.000	1.000
35	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), LTB4R(2), P2RY1(8), P2RY2(8), P2RY6(6)	3529174	69	53	62	19	29	15	10	12	3	0	0.0255	1.000	1.000
36	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(12), ACO2(7), FH(10), IDH1(21), IDH2(17), MDH1(8), MDH2(3), SDHB(3), SUCLA2(9)	6295485	90	82	79	23	17	23	12	25	13	0	0.0856	1.000	1.000
37	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(11), CD4(4), HLA-DRA(12), HLA-DRB1(7), IL1B(5), IL4(5), IL5RA(11), IL6(7)	3511210	64	44	58	18	21	11	6	18	5	3	0.248	1.000	1.000
38	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(12), ACO1(12), ACO2(7), ACSS1(7), ACSS2(10), FH(10), IDH1(21), IDH2(17), MDH1(8), MDH2(3), SUCLA2(9)	9335562	116	93	104	27	27	28	15	31	15	0	0.0187	1.000	1.000
39	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(4), GALT(3), TGDS(1), UGDH(9), UXS1(9)	2672136	26	25	27	6	6	2	4	6	8	0	0.490	1.000	1.000
40	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(5), CD4(4), CD80(6), HLA-DRA(12), HLA-DRB1(7), IL10(2), IL2(5), IL4(5)	2532472	46	33	44	12	12	8	6	12	5	3	0.290	1.000	1.000
41	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCR3(11), HLA-DRA(12), HLA-DRB1(7), IL3(6)	1765568	38	36	33	13	9	13	1	9	3	3	0.699	1.000	1.000
42	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(7), ACAT2(9), ACYP1(2), ECHS1(4), EHHADH(15), GCDH(8), HADHA(12), SDHB(3), SDS(3)	5405606	63	50	57	14	15	10	11	14	13	0	0.0664	1.000	1.000
43	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(9), SUCLA2(9)	1413285	18	17	18	7	8	2	3	3	2	0	0.594	1.000	1.000
44	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(4), RANBP1(6), RANBP2(32), RANGAP1(4)	5440776	46	35	43	8	8	7	6	17	8	0	0.0692	1.000	1.000
45	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(6), GLUD1(4), GLUD2(22)	3043522	34	32	34	9	12	6	2	12	2	0	0.368	1.000	1.000
46	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(14), RAB11A(4), RAB1A(2), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(4), RAB6A(4), RAB9A(3)	2927576	42	33	40	12	13	6	9	6	8	0	0.224	1.000	1.000
47	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(9)	1207021	14	12	14	6	4	1	3	5	1	0	0.726	1.000	1.000
48	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(9), PAPSS1(5), PAPSS2(7), SULT1A2(4), SULT1E1(6), SULT2A1(6), SUOX(5)	4786107	42	28	38	7	11	5	4	15	7	0	0.103	1.000	1.000
49	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(6), CBS(4), CTH(6), MUT(8)	3247633	27	22	27	6	10	1	7	4	5	0	0.160	1.000	1.000
50	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST3GAL5(2), ST6GALNAC2(6), ST6GALNAC4(4), ST8SIA1(10)	3762847	34	31	32	9	11	7	4	6	6	0	0.205	1.000	1.000
51	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(5), HSD3B7(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	3264996	27	24	24	7	11	4	1	8	3	0	0.324	1.000	1.000
52	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(2), CSF1(5), CSF3(3), EPO(1), IL11(6), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), IL9(2)	4283263	56	43	52	16	19	11	6	15	4	1	0.180	1.000	1.000
53	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	14	GATA3(17), IL13(2), IL4(5), MAF(9), MAP2K3(11), MAPK14(8), NFATC2(12), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	6718345	99	76	94	29	41	21	6	17	14	0	0.0862	1.000	1.000
54	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(15), PDXK(1), PDXP(1), PNPO(2), PSAT1(7)	3361327	26	22	25	7	6	7	3	6	4	0	0.341	1.000	1.000
55	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	5	ACACA(36), ACACB(40), MCAT(3), OLAH(10), OXSM(14)	8629635	103	67	91	18	31	16	17	19	19	1	0.00608	1.000	1.000
56	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(4), MMP14(7), MMP2(18), MMP9(19), RECK(14), TIMP1(2), TIMP2(3), TIMP3(11), TIMP4(4)	5166574	82	60	78	22	41	13	6	14	8	0	0.0665	1.000	1.000
57	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(13), DLL1(10), FURIN(17), PSEN1(4)	3217820	44	34	44	13	16	6	5	8	9	0	0.223	1.000	1.000
58	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(6), IDI1(4), SQLE(2)	2105761	16	16	17	5	1	2	4	5	4	0	0.601	1.000	1.000
59	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(7), ACAA2(4), ACAT1(7), ACAT2(9), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), SDS(3)	5892793	71	60	65	20	14	14	13	16	14	0	0.162	1.000	1.000
60	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(4), EHHADH(15), HADHA(12), SDS(3)	3381529	34	31	30	11	8	5	7	6	8	0	0.423	1.000	1.000
61	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(1), COQ5(2), COQ6(4), COQ7(1), NDUFA12(4), NDUFA13(3), NDUFB11(1)	2825492	18	18	21	6	6	1	7	2	2	0	0.476	1.000	1.000
62	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(6), GGPS1(5), IDI1(4), IDI2(3), SQLE(2)	2887472	24	23	24	7	4	2	4	7	7	0	0.562	1.000	1.000
63	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(7), ACOX1(11), ACOX3(10), ELOVL2(9), ELOVL5(3), ELOVL6(4), FADS2(12), HADHA(12), HSD17B12(3), SCD(4)	7469545	75	60	71	17	25	8	12	18	12	0	0.0305	1.000	1.000
64	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(14), CLOCK(24), CRY1(17), CRY2(5), CSNK1E(9), PER1(13)	5727864	82	56	60	17	21	13	4	22	20	2	0.164	1.000	1.000
65	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(15), PARK2(14), SNCA(2), SNCAIP(8), UBE2E2(4), UBE2F(2), UBE2G1(3), UBE2G2(1), UBE2L3(5)	4435755	54	42	53	17	16	2	9	20	7	0	0.409	1.000	1.000
66	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(14), KARS(8)	3412261	27	24	25	8	4	4	6	8	5	0	0.534	1.000	1.000
67	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	C9orf47(2), CNR1(13), CNR2(1), DNMT1(28), MTNR1A(3), MTNR1B(15), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2)	6920622	88	64	80	23	41	10	7	18	12	0	0.0149	1.000	1.000
68	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(27), GNAS(39), GNB1(3), GNGT1(1), PRKACA(2), PRKAR1A(8)	3947776	80	70	61	24	41	18	3	13	5	0	0.199	1.000	1.000
69	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(4), GBA3(3), LPO(10), MPO(17), PRDX6(5), TPO(36)	5518266	89	69	82	22	43	12	8	14	12	0	0.0534	1.000	1.000
70	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(11), CDC25B(11), CDC25C(6), CDK7(3), MNAT1(4), SHH(3), XPO1(9)	6040819	62	50	60	15	16	12	8	21	5	0	0.138	1.000	1.000
71	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(81), DAXX(18), HRAS(4), PAX3(26), PML(12), RARA(6), RB1(139), SIRT1(8), SP100(15), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TP53(435)	12541442	751	379	465	199	203	205	71	126	134	12	5.42e-06	1.000	1.000
72	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(19), G6PD(14), GCLC(8), GCLM(3), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), GSR(5), GSS(9), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), IDH1(21), IDH2(17), MGST1(2), MGST2(2), MGST3(1), TXNDC12(3)	13960006	209	133	175	44	41	49	29	56	34	0	0.000915	1.000	1.000
73	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(5), DPM2(1), EGR1(14), HRAS(4), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NGFR(5), RAF1(16)	5086719	74	56	64	23	32	9	9	14	10	0	0.143	1.000	1.000
74	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9)	3892945	46	41	42	17	5	15	6	16	4	0	0.524	1.000	1.000
75	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(8), CBS(4), CTH(6), GGT1(11), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), PAPSS1(5), PAPSS2(7), SCLY(12), SEPHS1(7)	8333402	96	68	82	24	26	10	15	20	25	0	0.0927	1.000	1.000
76	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(7), CYCS(1), GPD2(11), NDUFA1(2), SDHA(14), SDHB(3), SDHD(4), UQCRC1(4)	4494132	46	35	46	12	18	4	8	13	3	0	0.233	1.000	1.000
77	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(11), ACOX3(10), FADS2(12), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10)	7146239	74	54	70	18	30	11	8	15	10	0	0.0458	1.000	1.000
78	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), GBA3(3), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TPO(36), TYR(12)	6336993	104	78	95	28	48	17	10	17	12	0	0.0653	1.000	1.000
79	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), KARS(8)	5021396	52	44	47	15	8	9	10	16	9	0	0.422	1.000	1.000
80	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(21), CD3D(5), CD3E(2), CD3G(16), GZMB(5), HLA-A(26), ICAM1(4), ITGAL(21), ITGB2(18), PRF1(8)	5470130	126	84	98	36	32	16	6	19	50	3	0.533	1.000	1.000
81	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CARS(11), CTH(6), GOT1(7), GOT2(2), LDHA(14), LDHB(8), LDHC(4)	4555695	52	44	44	14	16	13	6	10	7	0	0.237	1.000	1.000
82	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(12), ALAS2(12), CPO(10), FECH(4), GATA1(19), HBB(3), HMBS(5), UROD(3), UROS(5)	5728569	74	52	68	18	23	17	7	17	10	0	0.113	1.000	1.000
83	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), RAC1(2), WASF1(6), WASL(18)	5691919	72	48	69	20	21	9	11	19	12	0	0.202	1.000	1.000
84	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NFS1(6), PHPT1(2), THTPA(2), TPK1(10)	4460825	58	48	53	16	18	13	7	12	8	0	0.292	1.000	1.000
85	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HSD3B7(3), PON1(12), PON2(7), PON3(14), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	5765037	77	58	67	23	20	19	8	19	11	0	0.262	1.000	1.000
86	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(2), CTSD(6), ESR1(21), GREB1(29), HSPB2(3), MTA1(6), MTA3(4), PDZK1(2), TUBA8(5)	6286975	78	55	77	25	29	8	10	16	15	0	0.293	1.000	1.000
87	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(1), DAG1(10), GNAQ(11), ITPKA(3), ITPKB(15)	3673735	44	37	41	15	15	9	3	11	6	0	0.476	1.000	1.000
88	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(10), FOS(5), JUN(2), MAPK3(4), OPRK1(14), POLR2A(14), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	8802767	87	71	83	22	34	15	5	15	18	0	0.0858	1.000	1.000
89	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(8), ANKRD1(9), ATF3(1), CYR61(2), HBEGF(1), IFNG(3), IFRD1(13), IL18(3), IL1A(1), IL1R1(7), MYOG(6), NR4A3(9), WDR1(7)	7302242	70	45	69	16	20	14	9	18	9	0	0.0669	1.000	1.000
90	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS(11), CARS2(6), CDO1(3), CTH(6), GOT1(7), GOT2(2), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), SDS(3), SULT1B1(6), SULT1C2(6), SULT1C4(3), SULT4A1(6)	8615564	98	70	88	25	31	19	12	23	13	0	0.0897	1.000	1.000
91	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(6), ICAM1(4), ITGAL(21), ITGAM(14), ITGB2(18), PECAM1(4), SELE(13), SELL(5)	6792830	85	64	93	27	30	14	9	16	16	0	0.291	1.000	1.000
92	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(3), GRB2(11), HBXIP(4), HRAS(4), PTK2B(13), SHC1(14), SOS1(16), SRC(3)	5976285	68	58	57	19	8	19	9	15	16	1	0.431	1.000	1.000
93	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GBA3(3), GGT1(11), SHMT1(7), SHMT2(5)	3523686	31	30	27	11	8	1	3	4	15	0	0.852	1.000	1.000
94	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	137	APC(683), AXIN1(10), AXIN2(27), BTRC(11), CACYBP(4), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CCND1(2), CCND2(3), CCND3(2), CER1(6), CHD8(37), CREBBP(81), CSNK1A1(3), CSNK1A1L(9), CSNK1E(9), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTBP1(5), CTBP2(14), CTNNB1(120), CTNNBIP1(1), CUL1(17), CXXC4(2), DAAM1(10), DAAM2(20), DKK1(9), DKK2(27), DKK4(8), DVL2(12), DVL3(10), EP300(56), FBXW11(13), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LEF1(9), LRP5(11), LRP6(34), MAP3K7(9), MAPK10(18), MAPK8(17), MAPK9(13), MMP7(10), MYC(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NKD1(6), NLK(12), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PORCN(3), PPARD(5), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRICKLE1(24), PRICKLE2(18), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PSEN1(4), RAC1(2), RAC2(1), RAC3(2), RBX1(1), RHOA(13), ROCK1(35), ROCK2(20), RUVBL1(9), SENP2(4), SFRP1(3), SFRP2(10), SFRP4(9), SFRP5(1), SIAH1(2), SKP1(2), SMAD2(24), SMAD3(22), SMAD4(191), TBL1X(9), TBL1XR1(11), TCF7(15), TCF7L1(8), TCF7L2(58), TP53(435), VANGL1(15), VANGL2(9), WIF1(5), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	101809810	2837	482	2053	835	643	634	294	507	591	168	1.62e-07	1.000	1.000
95	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(5), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), APC(683), ARAF(10), ARHGEF1(15), ARHGEF12(12), ARHGEF4(9), ARHGEF6(19), ARHGEF7(23), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), ARPC5(2), ARPC5L(4), BAIAP2(7), BCAR1(6), BDKRB1(4), BDKRB2(6), BRAF(125), CD14(6), CDC42(3), CFL1(2), CFL2(2), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CRKL(5), CSK(5), CYFIP1(16), CYFIP2(10), DIAPH1(7), DIAPH2(28), DIAPH3(19), DOCK1(24), EGF(8), EGFR(115), EZR(3), F2(10), F2R(11), FGD1(21), FGD3(16), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR3(26), FGFR4(12), FN1(58), GIT1(4), GNA12(7), GNA13(3), GNG12(8), GRLF1(19), GSN(4), HRAS(4), IQGAP1(31), IQGAP2(32), IQGAP3(24), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), KRAS(247), LIMK1(8), LIMK2(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MOS(10), MRAS(4), MSN(9), MYH10(17), MYH14(25), MYH9(43), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), NCKAP1(17), NCKAP1L(25), NRAS(45), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PFN2(4), PFN4(6), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R12B(33), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RDX(16), RHOA(13), ROCK1(35), ROCK2(20), RRAS(2), RRAS2(7), SCIN(10), SLC9A1(12), SOS1(16), SOS2(17), SSH1(15), SSH2(16), SSH3(4), TIAM1(42), TIAM2(26), TMSL3(2), VAV1(24), VAV2(20), VAV3(30), VCL(10), WAS(4), WASF1(6), WASF2(5), WASL(18)	184923416	3904	480	2894	1263	733	919	571	874	639	168	0.000348	1.000	1.000
96	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	241	ACVR1B(31), ACVR1C(11), AKT1(11), AKT2(8), AKT3(8), ARRB1(4), ARRB2(1), ATF2(7), ATF4(4), BDNF(5), BRAF(125), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CACNA2D1(31), CACNA2D2(9), CACNA2D3(24), CACNA2D4(13), CACNB1(6), CACNB2(11), CACNB3(3), CACNB4(4), CACNG1(5), CACNG2(6), CACNG3(12), CACNG4(4), CACNG5(9), CACNG6(4), CACNG7(9), CACNG8(2), CASP3(4), CD14(6), CDC25B(11), CDC42(3), CHUK(27), CRKL(5), DAXX(18), DDIT3(5), DUSP1(7), DUSP10(6), DUSP16(11), DUSP3(4), DUSP4(6), DUSP5(2), DUSP6(7), DUSP7(8), DUSP9(9), ECSIT(7), EGF(8), EGFR(115), ELK1(4), ELK4(5), FAS(9), FASLG(3), FGF1(3), FGF10(5), FGF11(3), FGF12(8), FGF13(11), FGF14(13), FGF16(3), FGF17(3), FGF18(3), FGF19(1), FGF2(5), FGF20(4), FGF21(2), FGF23(9), FGF3(5), FGF5(8), FGF6(5), FGF7(3), FGF8(4), FGF9(1), FGFR1(22), FGFR2(61), FGFR3(26), FGFR4(12), FLNA(31), FLNB(40), FLNC(39), FOS(5), GADD45G(1), GNA12(7), GNG12(8), GRB2(11), HRAS(4), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), JUN(2), KRAS(247), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K4(36), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAPT(11), MAX(5), MEF2C(15), MKNK1(4), MKNK2(7), MOS(10), MRAS(4), MYC(5), NF1(138), NFATC2(12), NFATC4(12), NFKB1(11), NFKB2(6), NLK(12), NR4A1(3), NRAS(45), NTF3(3), NTRK1(17), NTRK2(25), PAK1(11), PAK2(15), PDGFA(2), PDGFB(2), PDGFRA(64), PDGFRB(21), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PPM1A(9), PPM1B(6), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PPP5C(9), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTPN5(8), PTPN7(4), PTPRR(16), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF2(35), RASA1(24), RASA2(17), RASGRF1(25), RASGRF2(26), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KA6(18), RRAS(2), RRAS2(7), SOS1(16), SOS2(17), SRF(4), STK3(8), STK4(9), STMN1(2), TAOK1(17), TAOK2(14), TAOK3(20), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF1A(4), TP53(435), TRAF2(8), TRAF6(4), ZAK(12)	184347899	3576	475	2823	1060	945	742	518	835	514	22	9.20e-11	1.000	1.000
97	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(11), APC(683), AR(26), ASAH1(4), BRAF(125), CAMP(1), CCL13(1), CCL15(2), CCL16(2), DAG1(10), EGFR(115), GNA11(8), GNA15(6), GNAI1(5), GNAQ(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), MAPK10(18), MAPK14(8), PHKA2(19), PIK3CA(344), PIK3CD(11), PIK3R1(62), PITX2(2), PTX3(3), RAF1(16), SRC(3)	35303546	1683	456	1080	552	197	528	201	305	295	157	0.0116	1.000	1.000
98	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(683), AXIN1(10), CCND1(2), CCND2(3), CCND3(2), CSNK1E(9), CTNNB1(120), DVL2(12), DVL3(10), FBXW2(6), FOSL1(1), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GSK3B(17), JUN(2), LDLR(11), MAPK10(18), MAPK9(13), MYC(5), PAFAH1B1(6), PLAU(7), PPP2R5C(6), PPP2R5E(8), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), RAC1(2), RHOA(13), SFRP4(9), TCF7(15), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4)	36931539	1302	448	900	415	192	332	116	198	309	155	0.0201	1.000	1.000
99	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(11), APC(683), AXIN1(10), CCND1(2), CD14(6), CTNNB1(120), FZD1(9), GJA1(9), GNAI1(5), GSK3B(17), IRAK1(6), LBP(8), LEF1(9), LY96(4), MYD88(4), NFKB1(11), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), RELA(10), TIRAP(5), TLR4(18), TOLLIP(5), WNT1(7)	19556205	1372	444	810	433	107	470	170	193	275	157	7.66e-05	1.000	1.000
100	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	28	AKT1(11), AKT2(8), AKT3(8), ANKRD6(12), APC(683), AXIN1(10), AXIN2(27), CER1(6), CSNK1A1(3), CTNNB1(120), DACT1(19), DKK1(9), DKK2(27), DKK3(9), DKK4(8), FSTL1(10), GSK3A(6), GSK3B(17), LRP1(53), MVP(10), NKD1(6), PIN1(2), PSEN1(4), PTPRA(6), SENP2(4), SFRP1(3), TSHB(2), WIF1(5)	26192383	1088	442	711	331	126	282	97	162	264	157	0.0141	1.000	1.000
101	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(9), APC(683), ATF2(7), AXIN1(10), BMP10(15), BMP2(9), BMP4(6), BMP5(9), BMP7(15), BMPR1A(18), BMPR2(49), CHRD(16), CTNNB1(120), FZD1(9), GATA4(4), GSK3B(17), MAP3K7(9), MEF2C(15), MYL2(2), NPPA(1), NPPB(5), RFC1(25), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), WNT1(7)	23749948	1137	441	750	330	130	285	98	184	275	165	0.000406	1.000	1.000
102	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	191	ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), ARHGAP5(51), BAD(1), BCAR1(6), BCL2(2), BIRC2(7), BIRC3(18), BRAF(125), CAPN2(10), CAV1(1), CAV2(4), CAV3(4), CCND1(2), CCND2(3), CCND3(2), CDC42(3), CHAD(10), COL11A1(65), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), CRKL(5), CTNNB1(120), DIAPH1(7), DOCK1(24), EGF(8), EGFR(115), ELK1(4), ERBB2(37), FARP2(13), FIGF(6), FLNA(31), FLNB(40), FLNC(39), FLT1(43), FN1(58), FYN(17), GRB2(11), GRLF1(19), GSK3B(17), HGF(17), HRAS(4), IBSP(6), IGF1(6), IGF1R(22), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), JUN(2), KDR(42), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), MAP2K1(12), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MET(55), MYL2(2), MYL7(1), MYL9(3), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARVA(1), PARVB(9), PARVG(6), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PDPK1(4), PGF(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP5K1C(14), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PRKCA(8), PRKCG(24), PTEN(333), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF1(19), RELN(95), RHOA(13), ROCK1(35), ROCK2(20), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SPP1(4), SRC(3), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TLN1(23), TLN2(17), TNC(41), TNN(33), TNR(48), VASP(4), VAV1(24), VAV2(20), VAV3(30), VCL(10), VEGFA(5), VEGFB(3), VEGFC(15), VTN(13), VWF(36), ZYX(5)	240664066	4266	440	3550	1640	1017	1142	564	976	543	24	0.551	1.000	1.000
103	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(31), ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), ATM(237), ATR(53), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDC14A(14), CDC14B(6), CDC16(6), CDC20(3), CDC23(12), CDC25A(11), CDC25B(11), CDC25C(6), CDC26(1), CDC27(21), CDC6(10), CDC7(25), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CHEK1(11), CHEK2(30), CREBBP(81), CUL1(17), DBF4(11), E2F2(7), E2F3(6), EP300(56), ESPL1(23), FZR1(4), GADD45G(1), GSK3B(17), HDAC1(5), HDAC2(8), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTTG1(2), RB1(139), RBL1(21), RBL2(24), RBX1(1), SFN(1), SKP1(2), SKP2(3), SMAD2(24), SMAD3(22), SMAD4(191), SMC1A(21), SMC1B(28), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TP53(435), WEE1(15), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	93021636	2081	439	1537	640	446	572	210	452	373	28	0.00106	1.000	1.000
104	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(13), AKT1(11), AKT2(8), AKT3(8), APAF1(27), ATM(237), BAD(1), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIRC2(7), BIRC3(18), CAPN1(2), CAPN2(10), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CSF2RB(13), CYCS(1), DFFA(6), DFFB(2), ENDOG(3), FADD(1), FAS(9), FASLG(3), IKBKB(9), IKBKG(2), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL3(6), IRAK1(6), IRAK2(11), IRAK3(11), IRAK4(8), MAP3K14(6), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), NTRK1(17), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), RIPK1(7), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFRSF1A(4), TNFSF10(3), TP53(435), TRAF2(8)	56198569	1632	439	1096	505	337	490	209	320	261	15	0.000819	1.000	1.000
105	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(31), ATM(237), BUB1(16), BUB1B(13), BUB3(3), CCNA1(18), CCNA2(4), CCNB1(8), CCNB2(5), CCNB3(22), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNH(7), CDAN1(9), CDC14A(14), CDC14B(6), CDC20(3), CDC25A(11), CDC25B(11), CDC25C(6), CDC6(10), CDC7(25), CDH1(99), CDK2(5), CDK4(4), CDKN1A(2), CDKN2A(9), CHEK1(11), CHEK2(30), DTX4(8), E2F2(7), E2F3(6), E2F4(2), E2F5(6), E2F6(4), EP300(56), ESPL1(23), GSK3B(17), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), HDAC8(3), MAD1L1(13), MAD2L1(2), MAD2L2(4), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MPEG1(8), MPL(9), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), PLK1(16), PRKDC(85), PTPRA(6), PTTG1(2), RB1(139), RBL1(21), SKP2(3), SMAD4(191), TBC1D8(11), TFDP1(10), TGFB1(2), TP53(435), WEE1(15)	75401082	1870	437	1340	576	382	561	195	384	323	25	0.000391	1.000	1.000
106	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(683), AXIN1(10), CREBBP(81), CTNNB1(120), EP300(56), FZD1(9), GSK3B(17), HDAC1(5), LDB1(9), LEF1(9), PITX2(2), TRRAP(70), WNT1(7)	22125437	1078	434	690	342	105	309	101	145	263	155	0.00516	1.000	1.000
107	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(683), AXIN1(10), BTRC(11), CCND1(2), CREBBP(81), CSNK1A1(3), CSNK1D(15), CSNK2A1(7), CTBP1(5), CTNNB1(120), FZD1(9), GSK3B(17), HDAC1(5), MAP3K7(9), MYC(5), NLK(12), PPARD(5), PPP2CA(3), TLE1(7), WIF1(5), WNT1(7)	19002093	1021	432	648	321	81	278	102	149	256	155	0.00606	1.000	1.000
108	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(31), ABL2(20), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BRAF(125), BTC(3), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CBL(45), CBLB(17), CBLC(3), CDKN1A(2), CDKN1B(6), CRKL(5), EGF(8), EGFR(115), ELK1(4), ERBB2(37), ERBB3(32), ERBB4(65), EREG(3), GAB1(15), GRB2(11), GSK3B(17), HBEGF(1), HRAS(4), JUN(2), KRAS(247), MAP2K1(12), MAP2K2(3), MAP2K4(36), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MYC(5), NCK1(1), NCK2(5), NRAS(45), NRG1(33), NRG2(8), NRG3(18), NRG4(2), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), RAF1(16), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SRC(3), STAT5A(10), STAT5B(20)	69230187	1897	430	1263	606	298	541	385	460	209	4	0.000639	1.000	1.000
109	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(4), AKT1(11), APC(683), ASAH1(4), CAMP(1), CAV3(4), DAG1(10), DLG4(10), EPHB2(16), GNAI1(5), GNAQ(11), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PITX2(2), PTX3(3), RAC1(2), RHO(5), RYR1(70)	30404752	1010	430	708	325	153	220	91	146	244	156	0.0508	1.000	1.000
110	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(683), CDH1(99), CREBBP(81), EP300(56), MAP2K1(12), MAP3K7(9), MAPK3(4), SKIL(9), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26)	18243620	1013	429	652	304	95	282	89	127	265	155	0.000388	1.000	1.000
111	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(27), ATM(237), ATR(53), BAI1(13), BAX(16), BID(2), CASP3(4), CASP8(20), CASP9(6), CCNB1(8), CCNB2(5), CCNB3(22), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG1(5), CCNG2(4), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN2A(9), CHEK1(11), CHEK2(30), CYCS(1), DDB2(1), EI24(1), FAS(9), GADD45G(1), GTSE1(5), IGF1(6), IGFBP3(8), MDM2(11), MDM4(7), PPM1D(6), PTEN(333), RCHY1(4), RFWD2(6), RPRM(2), RRM2(5), RRM2B(5), SERPINB5(7), SERPINE1(10), SESN1(5), SESN2(9), SESN3(8), SFN(1), SIAH1(2), STEAP3(6), THBS1(14), TNFRSF10B(8), TP53(435), TP53I3(2), TP73(5), TSC2(17), ZMAT3(12)	42212966	1454	427	984	467	261	470	162	285	252	24	0.0127	1.000	1.000
112	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(31), ABLIM1(11), ABLIM2(7), ABLIM3(17), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CFL2(2), CXCL12(2), CXCR4(7), DCC(42), DPYSL2(11), DPYSL5(10), EFNA1(1), EFNA3(2), EFNA4(5), EFNA5(6), EFNB1(6), EFNB2(1), EFNB3(11), EPHA1(11), EPHA2(12), EPHA3(70), EPHA4(26), EPHA5(47), EPHA6(28), EPHA7(45), EPHA8(19), EPHB1(38), EPHB2(16), EPHB3(12), EPHB4(15), EPHB6(15), FES(7), FYN(17), GNAI1(5), GNAI2(2), GNAI3(2), GSK3B(17), HRAS(4), ITGB1(13), KRAS(247), L1CAM(17), LIMK1(8), LIMK2(13), LRRC4C(17), MAPK1(3), MAPK3(4), MET(55), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NGEF(19), NRAS(45), NRP1(12), NTN1(5), NTN4(10), NTNG1(17), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLXNA1(22), PLXNA2(26), PLXNA3(24), PLXNB1(22), PLXNB2(28), PLXNB3(25), PLXNC1(20), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTK2(24), RAC1(2), RAC2(1), RAC3(2), RASA1(24), RGS3(25), RHOA(13), RND1(3), ROBO1(32), ROBO2(65), ROBO3(12), ROCK1(35), ROCK2(20), SEMA3A(21), SEMA3B(7), SEMA3C(18), SEMA3D(29), SEMA3E(22), SEMA3F(13), SEMA3G(10), SEMA4A(13), SEMA4B(5), SEMA4C(5), SEMA4D(18), SEMA4F(14), SEMA4G(11), SEMA5A(21), SEMA5B(26), SEMA6A(9), SEMA6B(8), SEMA6C(13), SEMA6D(15), SEMA7A(3), SLIT1(31), SLIT2(33), SLIT3(25), SRGAP1(25), SRGAP2(9), SRGAP3(21), UNC5A(9), UNC5B(10), UNC5C(17), UNC5D(22)	123494163	2155	426	1774	686	606	372	338	526	305	8	0.000951	1.000	1.000
113	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	125	ACACA(36), ACACB(40), AKT1(11), AKT2(8), AKT3(8), ARAF(10), BAD(1), BRAF(125), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CBL(45), CBLB(17), CBLC(3), CRKL(5), ELK1(4), EXOC7(4), FBP1(1), FBP2(5), FLOT1(7), FLOT2(2), FOXO1(8), G6PC(5), G6PC2(3), GCK(6), GRB2(11), GSK3B(17), GYS1(6), GYS2(17), HRAS(4), IKBKB(9), INPP5D(10), INSR(21), IRS1(21), IRS4(36), KRAS(247), LIPE(11), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK9(13), MKNK1(4), MKNK2(7), NRAS(45), PCK1(6), PCK2(6), PDE3A(21), PDE3B(10), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PKLR(12), PKM2(4), PPARGC1A(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R3A(45), PPP1R3B(4), PPP1R3C(6), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACA(2), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCI(25), PRKCZ(4), PRKX(3), PTPN1(11), PTPRF(23), PYGB(15), PYGL(8), PYGM(12), RAF1(16), RAPGEF1(19), RHEB(5), RHOQ(6), RPS6(3), RPS6KB1(9), RPS6KB2(6), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SLC2A4(8), SOCS2(4), SOCS4(1), SORBS1(15), SOS1(16), SOS2(17), SREBF1(8), TRIP10(5), TSC1(18), TSC2(17)	102437833	2008	425	1407	627	409	484	381	511	219	4	2.66e-05	1.000	1.000
114	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	165	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY7(13), ADCY8(34), ADCY9(22), ADORA2A(7), ADORA2B(5), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), ATP2A1(24), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), ATP2B4(26), AVPR1A(15), AVPR1B(5), BDKRB1(4), BDKRB2(6), BST1(3), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1F(37), CACNA1G(29), CACNA1I(19), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CCKAR(9), CCKBR(16), CD38(5), CHRM1(4), CHRM2(29), CHRM3(23), CHRM5(6), CHRNA7(1), CYSLTR1(9), CYSLTR2(18), DRD1(9), EDNRA(9), EDNRB(19), EGFR(115), ERBB2(37), ERBB3(32), ERBB4(65), F2R(11), GNA11(8), GNA14(13), GNA15(6), GNAL(5), GNAQ(11), GNAS(39), GRIN1(5), GRIN2A(55), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), GRPR(4), HRH1(4), HRH2(16), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), LHCGR(27), MYLK(33), MYLK2(10), NOS1(31), NOS3(23), NTSR1(5), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), PDE1A(10), PDE1B(11), PDE1C(19), PDGFRA(64), PDGFRB(21), PHKA1(14), PHKA2(19), PHKB(17), PHKG1(4), PHKG2(4), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PLN(1), PPID(5), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), PTAFR(1), PTGER3(17), PTGFR(8), PTK2B(13), RYR1(70), RYR2(138), RYR3(84), SLC25A4(4), SLC25A5(10), SLC8A1(24), SLC8A2(16), SLC8A3(17), SPHK1(3), SPHK2(5), TACR1(9), TACR2(4), TACR3(18), TNNC1(2), TNNC2(1), TRHR(9), TRPC1(17), VDAC1(6), VDAC2(4), VDAC3(2)	172977681	2761	424	2593	1008	953	534	305	604	354	11	0.222	1.000	1.000
115	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), AKT1(11), AKT2(8), AKT3(8), AMOTL1(15), ASH1L(64), CASK(11), CDC42(3), CDK4(4), CGN(18), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CRB3(1), CSDA(3), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTTN(5), EPB41(11), EPB41L1(14), EPB41L2(12), EPB41L3(35), EXOC3(3), EXOC4(22), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), HCLS1(16), HRAS(4), IGSF5(16), INADL(18), JAM2(2), JAM3(9), KRAS(247), LLGL1(7), LLGL2(8), MAGI1(31), MAGI2(32), MAGI3(10), MLLT4(21), MPDZ(26), MPP5(7), MRAS(4), MYH1(47), MYH10(17), MYH11(49), MYH13(28), MYH14(25), MYH15(37), MYH2(42), MYH3(46), MYH4(30), MYH6(34), MYH7(28), MYH7B(31), MYH8(47), MYH9(43), MYL2(2), MYL7(1), MYL9(3), NRAS(45), OCLN(2), PARD3(13), PARD6A(2), PARD6B(2), PARD6G(7), PPM1J(3), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PPP2R3A(16), PPP2R4(4), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PTEN(333), RAB13(1), RAB3B(3), RHOA(13), RRAS(2), RRAS2(7), SPTAN1(30), SRC(3), SYMPK(11), TJAP1(5), TJP1(25), TJP2(17), TJP3(12), VAPA(2), YES1(10), ZAK(12)	129113469	2336	424	1799	749	572	539	386	541	280	18	0.00107	1.000	1.000
116	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRB1(4), CSNK1D(15), DRD1(9), DRD2(9), EGF(8), EGFR(115), GJA1(9), GJD2(5), GNA11(8), GNAI1(5), GNAI2(2), GNAI3(2), GNAQ(11), GNAS(39), GRB2(11), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), HTR2A(24), HTR2B(7), HTR2C(15), ITPR1(43), ITPR2(49), ITPR3(44), KRAS(247), MAP2K1(12), MAP2K2(3), MAP2K5(6), MAP3K2(9), MAPK1(3), MAPK3(4), MAPK7(6), NPR1(18), NPR2(17), NRAS(45), PDGFA(2), PDGFB(2), PDGFC(10), PDGFD(12), PDGFRA(64), PDGFRB(21), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), PRKX(3), RAF1(16), SOS1(16), SOS2(17), SRC(3), TJP1(25), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10)	87463031	1675	424	1315	538	450	320	317	432	152	4	0.000104	1.000	1.000
117	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(10), BID(2), BRAF(125), CASP3(4), CD244(7), CD247(3), CD48(2), FAS(9), FASLG(3), FCGR3A(5), FCGR3B(2), FYN(17), GRB2(11), GZMB(5), HCST(2), HLA-A(26), HLA-B(22), HLA-C(13), HLA-E(4), HLA-G(13), HRAS(4), ICAM1(4), ICAM2(6), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(10), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), ITGAL(21), ITGB2(18), KIR2DL1(10), KIR2DL3(20), KIR2DL4(5), KIR3DL1(10), KIR3DL2(7), KLRC1(2), KLRC2(2), KLRC3(8), KLRD1(3), KLRK1(8), KRAS(247), LAT(3), LCK(9), LCP2(10), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MICB(4), NCR1(3), NCR2(2), NCR3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NRAS(45), PAK1(11), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRF1(8), PRKCA(8), PRKCG(24), PTK2B(13), PTPN11(41), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SH2D1A(3), SH2D1B(1), SH3BP2(7), SHC1(14), SHC2(2), SHC3(5), SHC4(8), SOS1(16), SOS2(17), SYK(8), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFSF10(3), TYROBP(1), ULBP1(7), ULBP2(2), ULBP3(6), VAV1(24), VAV2(20), VAV3(30), ZAP70(12)	74881922	1799	424	1165	546	302	458	351	460	217	11	4.02e-05	1.000	1.000
118	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	224	ADCYAP1R1(5), ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), ADRA1A(12), ADRA1B(6), ADRA2A(5), ADRA2B(7), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), C5AR1(8), CALCR(12), CALCRL(9), CCKAR(9), CCKBR(16), CGA(3), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CNR1(13), CNR2(1), CRHR1(6), CRHR2(6), CTSG(5), CYSLTR1(9), CYSLTR2(18), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2(10), F2R(11), F2RL1(8), F2RL2(8), FPR1(8), FSHB(6), FSHR(19), GABBR1(20), GABBR2(23), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GABRB1(11), GABRB2(10), GABRB3(19), GABRD(6), GABRE(12), GABRG1(21), GABRG2(20), GABRG3(12), GABRP(13), GABRQ(19), GABRR1(5), GABRR2(8), GALR1(5), GH1(5), GH2(6), GHR(12), GHRHR(2), GHSR(9), GIPR(1), GLP1R(11), GLP2R(10), GLRA1(10), GLRA2(9), GLRA3(13), GLRB(14), GNRHR(9), GPR156(17), GPR35(3), GPR50(9), GPR63(7), GPR83(7), GRIA1(38), GRIA2(29), GRIA3(15), GRIA4(46), GRID1(30), GRID2(28), GRIK1(13), GRIK2(49), GRIK3(33), GRIK4(21), GRIK5(15), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRIN3A(19), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM6(27), GRM7(36), GRM8(29), GRPR(4), GZMA(11), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HRH4(6), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LEP(1), LEPR(21), LHB(3), LHCGR(27), LTB4R(2), MAS1(3), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), MCHR1(8), MCHR2(23), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPBWR1(7), NPBWR2(1), NPFFR1(1), NPFFR2(14), NPY1R(6), NPY2R(12), NPY5R(7), NR3C1(11), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), P2RX1(2), P2RX2(6), P2RX3(5), P2RX4(5), P2RX5(3), P2RX7(13), P2RY1(8), P2RY10(15), P2RY11(5), P2RY13(18), P2RY14(11), P2RY2(8), P2RY4(8), P2RY6(6), PARD3(13), PPYR1(8), PRL(4), PRLHR(5), PRLR(10), PRSS1(7), PRSS3(6), PTAFR(1), PTGDR(9), PTGER2(2), PTGER3(17), PTGER4(4), PTGFR(8), PTGIR(2), PTH2R(16), RXFP1(7), RXFP2(21), SCTR(6), SSTR1(12), SSTR2(6), SSTR4(14), TAAR1(7), TAAR2(7), TAAR5(10), TAAR6(7), TAAR8(6), TAAR9(6), TACR1(9), TACR2(4), TACR3(18), THRA(6), THRB(14), TRHR(9), TRPV1(11), TSHB(2), TSHR(59), VIPR1(7), VIPR2(11)	143179534	2606	422	2331	927	887	475	295	632	311	6	0.0149	1.000	1.000
119	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(13), APC(683), AXIN1(10), BTRC(11), CTNNB1(120), DLL1(10), FZD1(9), GSK3B(17), PSEN1(4), WNT1(7)	10915034	884	422	528	263	46	245	78	124	236	155	0.000515	1.000	1.000
120	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	23	APC(683), ASAH1(4), CAMP(1), CASP3(4), CERK(3), CREB1(3), CREB3(6), CREB5(8), DAG1(10), EPHB2(16), FOS(5), GNAQ(11), ITPKA(3), ITPKB(15), JUN(2), MAP2K4(36), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13)	17355253	879	422	568	252	67	211	75	129	242	155	0.000592	1.000	1.000
121	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(11), AKT2(8), AKT3(8), BCL10(8), CARD11(59), CBL(45), CBLB(17), CBLC(3), CD247(3), CD28(5), CD3D(5), CD3E(2), CD3G(16), CD4(4), CD40LG(10), CD8A(2), CD8B(4), CDC42(3), CDK4(4), CHUK(27), CTLA4(5), FOS(5), FYN(17), GRAP2(7), GRB2(11), HRAS(4), ICOS(2), IFNG(3), IKBKB(9), IKBKG(2), IL10(2), IL2(5), IL4(5), ITK(26), JUN(2), KRAS(247), LAT(3), LCK(9), LCP2(10), MALT1(13), MAP3K14(6), MAP3K8(4), NCK1(1), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NRAS(45), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDCD1(2), PDK1(7), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCQ(16), PTPN6(4), PTPRC(36), RASGRP1(8), RHOA(13), SOS1(16), SOS2(17), TEC(10), TNF(2), VAV1(24), VAV2(20), VAV3(30), ZAP70(12)	67388424	1591	418	1055	460	277	432	330	364	186	2	2.36e-07	1.000	1.000
122	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(237), CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNE2(3), CCNG2(4), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), CREB3(6), CREB3L1(6), CREB3L3(7), CREB3L4(5), E2F2(7), E2F3(6), E2F4(2), E2F5(6), E2F6(4), GBA2(15), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), MDM2(11), MNAT1(4), MYC(5), MYT1(25), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLE(41), POLE2(6), PRIM1(5), RB1(139), RBL1(21), RPA1(12), RPA2(1), RPA3(4), TFDP1(10), TFDP2(5), TP53(435), WEE1(15)	47130787	1232	417	876	354	267	334	131	266	214	20	3.76e-05	1.000	1.000
123	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ASIP(2), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), CREB3(6), CREB3L1(6), CREB3L2(5), CREB3L3(7), CREB3L4(5), CREBBP(81), CTNNB1(120), DCT(22), DVL2(12), DVL3(10), EDN1(3), EDNRB(19), EP300(56), FZD1(9), FZD10(13), FZD2(10), FZD3(17), FZD4(5), FZD5(1), FZD6(18), FZD7(12), FZD8(5), FZD9(6), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAS(39), GSK3B(17), HRAS(4), KIT(161), KITLG(3), KRAS(247), LEF1(9), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MC1R(2), MITF(19), NRAS(45), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), POMC(4), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAF1(16), TCF7(15), TCF7L1(8), TCF7L2(58), TYR(12), TYRP1(6), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	69770896	1621	416	1186	538	412	366	296	370	177	0	0.00161	1.000	1.000
124	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ATF4(4), CACNA1C(35), CACNA1D(29), CACNA1F(37), CACNA1S(34), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDC42(3), CGA(3), EGFR(115), ELK1(4), FSHB(6), GNA11(8), GNAQ(11), GNAS(39), GNRH1(4), GNRH2(6), GNRHR(9), GRB2(11), HBEGF(1), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), KRAS(247), LHB(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAP3K1(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK7(6), MAPK8(17), MAPK9(13), MMP14(7), MMP2(18), NRAS(45), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLD1(19), PLD2(10), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCD(15), PRKX(3), PTK2B(13), RAF1(16), SOS1(16), SOS2(17), SRC(3)	85086603	1536	408	1201	458	396	279	293	394	170	4	5.16e-06	1.000	1.000
125	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(11), AKT2(8), AKT3(8), BTK(12), FCER1A(6), FYN(17), GAB2(10), GRB2(11), HRAS(4), IL13(2), IL3(6), IL4(5), INPP5D(10), KRAS(247), LAT(3), LCP2(10), LYN(13), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MS4A2(6), NRAS(45), PDK1(7), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PRKCA(8), PRKCD(15), PRKCE(6), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SOS1(16), SOS2(17), SYK(8), TNF(2), VAV1(24), VAV2(20), VAV3(30)	47629056	1315	406	827	373	216	362	301	321	112	3	2.89e-07	1.000	1.000
126	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(11), AKT2(8), AKT3(8), BCL10(8), BLNK(2), BTK(12), CARD11(59), CD19(10), CD22(17), CD72(4), CD79A(6), CD79B(3), CHUK(27), CR2(22), FCGR2B(2), FOS(5), GSK3B(17), HRAS(4), IFITM1(2), IKBKB(9), IKBKG(2), INPP5D(10), JUN(2), KRAS(247), LILRB3(8), LYN(13), MALT1(13), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NRAS(45), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PTPN6(4), RAC1(2), RAC2(1), RAC3(2), RASGRP3(9), SYK(8), VAV1(24), VAV2(20), VAV3(30)	48874387	1284	405	797	365	220	346	293	302	121	2	1.18e-07	1.000	1.000
127	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(27), ADCY8(34), ARAF(10), ATF4(4), BRAF(125), CACNA1C(35), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CREBBP(81), EP300(56), GNAQ(11), GRIA1(38), GRIA2(29), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), GRM1(37), GRM5(33), HRAS(4), ITPR1(43), ITPR2(49), ITPR3(44), KRAS(247), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NRAS(45), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PPP1CA(2), PPP1CB(6), PPP1CC(2), PPP1R12A(18), PPP1R1A(1), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKACA(2), PRKACB(5), PRKACG(9), PRKCA(8), PRKCG(24), PRKX(3), RAF1(16), RAP1A(2), RAP1B(2), RAPGEF3(8), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18)	67012041	1406	404	1030	462	339	288	258	379	139	3	0.00447	1.000	1.000
128	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(237), ATR(53), BRCA1(32), CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CDC34(2), CDKN1A(2), CDKN2D(1), CHEK1(11), CHEK2(30), EP300(56), MDM2(11), MYT1(25), PRKDC(85), RPS6KA1(9), TP53(435), WEE1(15), YWHAH(5), YWHAQ(1)	28761464	1046	402	698	313	232	293	104	207	194	16	0.00322	1.000	1.000
129	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(10), BRAF(125), C7orf16(11), CACNA1A(28), CRHR1(6), GNA11(8), GNA12(7), GNA13(3), GNAI1(5), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAS(39), GNAZ(5), GRIA1(38), GRIA2(29), GRIA3(15), GRID2(28), GRM1(37), GRM5(33), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HRAS(4), IGF1(6), IGF1R(22), ITPR1(43), ITPR2(49), ITPR3(44), KRAS(247), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), NOS1(31), NOS3(23), NPR1(18), NPR2(17), NRAS(45), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), PRKCA(8), PRKCG(24), PRKG1(18), PRKG2(12), RAF1(16), RYR1(70)	73765414	1483	402	1102	473	392	245	275	416	152	3	0.00224	1.000	1.000
130	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	15	ABL1(31), CDKN2A(9), MDM2(11), MYC(5), PIK3CA(344), PIK3R1(62), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), RAC1(2), RB1(139), TP53(435), TWIST1(3)	13250271	1083	400	613	306	210	383	154	176	146	14	3.80e-07	1.000	1.000
131	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(31), ATM(237), ATR(53), CCNA1(18), CCND1(2), CCNE1(6), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), DHFR(1), GSK3B(17), HDAC1(5), RB1(139), SKP2(3), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TP53(435)	20821947	1011	400	663	300	225	295	90	190	188	23	0.000788	1.000	1.000
132	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(237), ATR(53), BRCA1(32), BRCA2(99), CHEK1(11), CHEK2(30), FANCA(12), FANCC(8), FANCD2(42), FANCE(4), FANCF(4), FANCG(7), HUS1(8), MRE11A(20), RAD1(2), RAD17(9), RAD50(30), RAD9A(1), TP53(435), TREX1(3)	31314191	1047	399	673	310	201	288	96	220	226	16	0.0226	1.000	1.000
133	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(11), AKT2(8), AKT3(8), BAD(1), CASP9(6), CDC42(3), HRAS(4), KDR(42), KRAS(247), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPKAPK2(5), MAPKAPK3(6), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NOS3(23), NRAS(45), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCG1(19), PLCG2(28), PPP3CA(5), PPP3CB(11), PPP3CC(7), PPP3R1(4), PPP3R2(1), PRKCA(8), PRKCG(24), PTGS2(10), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAF1(16), SH2D2A(5), SHC2(2), SPHK1(3), SPHK2(5), SRC(3), VEGFA(5)	45957392	1201	399	721	374	219	309	282	274	115	2	0.000189	1.000	1.000
134	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CDK2(5), CDK4(4), CHEK1(11), MYT1(25), RB1(139), TP53(435), WEE1(15), YWHAH(5)	12552850	904	397	566	238	204	270	79	176	155	20	1.84e-05	1.000	1.000
135	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	55	ALG2(8), BAK1(2), BAX(16), BFAR(9), BTK(12), CAD(23), CASP10(7), CASP3(4), CASP8(20), CASP8AP2(30), CD7(6), CSNK1A1(3), DAXX(18), DEDD(3), DEDD2(1), DFFA(6), DIABLO(3), EGFR(115), EPHB2(16), FADD(1), FAF1(11), FAIM2(6), IL1A(1), IL8(6), MAP2K4(36), MAP3K1(21), MAP3K5(16), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MET(55), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PFN2(4), PTPN13(23), RALBP1(8), RIPK1(7), ROCK1(35), SMPD1(10), TP53(435), TPX2(10), TRAF2(8), TUFM(6)	46124298	1104	397	818	299	266	270	124	244	188	12	1.36e-05	1.000	1.000
136	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	134	ACTB(4), ACTG1(6), CHAD(10), COL11A1(65), COL11A2(19), COL17A1(16), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), COMP(6), DES(6), DSC1(14), DSC2(17), DSC3(13), DSG1(23), DSG2(12), DSG3(17), DSG4(29), FN1(58), GJA1(9), GJA10(17), GJA3(5), GJA4(3), GJA5(7), GJA8(22), GJA9(6), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GJB7(4), GJC1(10), GJC3(4), GJD2(5), GJD4(4), IBSP(6), INA(9), ITGA6(16), ITGB4(18), KRT1(19), KRT10(7), KRT12(7), KRT13(11), KRT14(10), KRT15(9), KRT16(5), KRT17(11), KRT18(3), KRT19(4), KRT2(15), KRT20(3), KRT23(9), KRT24(5), KRT25(12), KRT27(3), KRT28(5), KRT3(13), KRT31(12), KRT32(7), KRT33A(8), KRT33B(6), KRT34(11), KRT35(7), KRT36(5), KRT37(11), KRT38(3), KRT39(9), KRT4(36), KRT40(2), KRT5(8), KRT6A(8), KRT6B(6), KRT6C(7), KRT7(6), KRT71(9), KRT72(14), KRT73(14), KRT74(9), KRT75(14), KRT76(9), KRT77(6), KRT78(6), KRT79(8), KRT8(4), KRT81(3), KRT82(7), KRT83(4), KRT84(12), KRT85(15), KRT86(4), KRT9(13), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), LMNA(1), LMNB1(11), LMNB2(3), NES(30), PRPH(3), RELN(95), SPP1(4), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VIM(9), VTN(13), VWF(36)	159764754	2186	396	2023	863	762	314	297	497	313	3	0.856	1.000	1.000
137	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(11), APAF1(27), ATM(237), BAD(1), BAX(16), BCL2(2), BCL2L1(1), BID(2), CASP3(4), CASP6(3), CASP7(3), CASP9(6), CYCS(1), EIF2S1(3), PRKCA(8), PTK2(24), PXN(2), STAT1(17), TLN1(23), TP53(435)	19108377	826	393	524	236	191	219	85	159	158	14	0.00302	1.000	1.000
138	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(27), ATM(237), BAX(16), BCL2(2), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDKN1A(2), MDM2(11), PCNA(5), RB1(139), TIMP3(11), TP53(435)	12774789	902	393	553	249	191	268	79	175	168	21	0.000203	1.000	1.000
139	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(31), ATM(237), BRCA1(32), CDKN1A(2), CHEK1(11), CHEK2(30), JUN(2), MAPK8(17), MDM2(11), MRE11A(20), NFKB1(11), NFKBIA(1), RAD50(30), RBBP8(15), RELA(10), TP53(435), TP73(5)	20331344	900	391	575	280	200	261	81	175	170	13	0.0612	1.000	1.000
140	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(35), AKT1(11), ATM(237), BAX(16), CDKN1A(2), CPB2(11), CSNK1A1(3), CSNK1D(15), FHL2(3), HIF1A(16), IGFBP3(8), MAPK8(17), MDM2(11), NFKBIB(5), NQO1(1), TP53(435)	13746032	826	391	527	206	189	220	83	167	154	13	1.01e-05	1.000	1.000
141	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(11), ATF2(7), CDC42(3), DLD(4), DUSP10(6), DUSP4(6), GAB1(15), GCK(6), IL1R1(7), JUN(2), MAP2K4(36), MAP2K5(6), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK10(18), MAPK7(6), MAPK8(17), MAPK9(13), MYEF2(14), NFATC3(15), NR2C2(11), PAPPA(39), SHC1(14), TP53(435), TRAF6(4), ZAK(12)	33463208	895	391	623	203	249	167	110	181	181	7	1.80e-08	1.000	1.000
142	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(27), BAD(1), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), BIRC2(7), BIRC3(18), BIRC5(2), BNIP3L(4), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), GZMB(5), HELLS(13), IKBKB(9), IKBKG(2), IRF1(6), IRF2(10), IRF3(4), IRF4(5), IRF5(6), IRF6(6), JUN(2), LTA(1), MAP2K4(36), MAP3K1(21), MAPK10(18), MDM2(11), MYC(5), NFKB1(11), NFKBIA(1), NFKBIB(5), NFKBIE(5), PLEKHG5(9), PRF1(8), RELA(10), RIPK1(7), TNF(2), TNFRSF10B(8), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFSF10(3), TP53(435), TP73(5), TRAF1(7), TRAF2(8), TRAF3(12)	37669656	914	388	635	222	240	183	105	182	198	6	7.84e-07	1.000	1.000
143	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(237), ATR(53), CDC25C(6), CHEK1(11), CHEK2(30), TP53(435), YWHAH(5)	11502007	777	385	465	214	174	219	72	147	150	15	0.00429	1.000	1.000
144	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(125), CPEB1(10), EGFR(115), ERBB2(37), ERBB4(65), ETS1(10), ETS2(5), ETV6(11), ETV7(3), FMN2(77), GRB2(11), KRAS(247), MAP2K1(12), MAPK1(3), MAPK3(4), NOTCH2(35), NOTCH3(31), NOTCH4(20), PIWIL1(31), PIWIL2(16), PIWIL3(15), PIWIL4(10), RAF1(16), SOS1(16), SOS2(17), SPIRE1(6), SPIRE2(9)	32164258	957	384	587	242	148	203	213	283	110	0	1.41e-06	1.000	1.000
145	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), AKAP1(7), AKAP10(6), AKAP11(30), AKAP12(36), AKAP2(2), AKAP3(26), AKAP4(16), AKAP5(6), AKAP6(44), AKAP7(21), AKAP8(8), AKAP9(75), ARHGEF1(15), CALM2(1), CALM3(1), CHMP1B(1), GNA11(8), GNA12(7), GNA13(3), GNA14(13), GNA15(6), GNAI2(2), GNAI3(2), GNAL(5), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB5(3), GNG12(8), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), HRAS(4), IL18BP(4), ITPR1(43), KCNJ3(11), KRAS(247), NRAS(45), PALM2(1), PDE1A(10), PDE1B(11), PDE1C(19), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PLCB3(15), PPP3CA(5), PPP3CC(7), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCI(25), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKD3(19), RHOA(13), RRAS(2), SLC9A1(12), USP5(10)	78989693	1335	383	1012	399	311	213	258	344	206	3	8.06e-05	1.000	1.000
146	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(11), BCL2(2), EGFR(115), IGF1R(22), MYC(5), POLR2A(14), PPP2CA(3), PRKCA(8), RB1(139), TEP1(29), TERF1(6), TERT(10), TNKS(11), TP53(435), XRCC5(13)	19244217	823	381	531	234	211	232	90	142	136	12	6.94e-05	1.000	1.000
147	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(5), ACTB(4), ACTG1(6), ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), ACVR1B(31), ACVR1C(11), BAIAP2(7), CDC42(3), CDH1(99), CREBBP(81), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTNND1(19), EGFR(115), EP300(56), ERBB2(37), FARP2(13), FER(18), FGFR1(22), FYN(17), IGF1R(22), INSR(21), IQGAP1(31), LEF1(9), LMO7(33), MAP3K7(9), MAPK1(3), MAPK3(4), MET(55), MLLT4(21), NLK(12), PARD3(13), PTPN1(11), PTPN6(4), PTPRB(21), PTPRF(23), PTPRJ(18), PTPRM(48), PVRL1(9), PVRL2(5), PVRL3(5), PVRL4(11), RAC1(2), RAC2(1), RAC3(2), RHOA(13), SMAD2(24), SMAD3(22), SMAD4(191), SNAI1(6), SNAI2(11), SORBS1(15), SRC(3), SSX2IP(9), TCF7(15), TCF7L1(8), TCF7L2(58), TGFBR1(20), TGFBR2(26), TJP1(25), VCL(10), WAS(4), WASF1(6), WASF2(5), WASF3(17), WASL(18), YES1(10)	81134802	1729	376	1415	552	389	470	220	364	277	9	0.00144	1.000	1.000
148	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	CD36(3), CD44(6), CD47(8), CHAD(10), COL11A1(65), COL11A2(19), COL1A1(21), COL1A2(27), COL2A1(20), COL3A1(34), COL4A1(26), COL4A2(18), COL4A4(27), COL4A6(26), COL5A1(47), COL5A2(24), COL5A3(26), COL6A1(12), COL6A2(15), COL6A3(86), COL6A6(51), DAG1(10), FN1(58), FNDC1(44), FNDC3A(15), FNDC4(6), FNDC5(2), GP5(9), GP6(13), GP9(1), HMMR(17), HSPG2(27), IBSP(6), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAV(21), ITGB1(13), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), LAMA1(66), LAMA2(57), LAMA3(43), LAMA4(39), LAMA5(35), LAMB1(20), LAMB2(16), LAMB3(16), LAMB4(41), LAMC1(26), LAMC2(18), LAMC3(20), RELN(95), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SPP1(4), SV2A(24), SV2B(11), SV2C(13), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNC(41), TNN(33), TNR(48), VTN(13), VWF(36)	143247103	1883	372	1774	762	628	277	248	456	268	6	0.888	1.000	1.000
149	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	240	ACVR1(9), ACVR1B(31), ACVR2A(66), ACVR2B(14), AMHR2(4), BMP2(9), BMP7(15), BMPR1A(18), BMPR1B(15), BMPR2(49), CCL11(2), CCL13(1), CCL14(4), CCL15(2), CCL16(2), CCL17(1), CCL18(2), CCL22(1), CCL23(3), CCL24(2), CCL25(2), CCL26(2), CCL27(2), CCL28(4), CCL4(1), CCL7(2), CCL8(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CD27(4), CD40(7), CD40LG(10), CD70(5), CLCF1(2), CNTF(3), CNTFR(10), CSF1(5), CSF1R(16), CSF2RB(13), CSF3(3), CSF3R(19), CX3CL1(5), CX3CR1(6), CXCL1(1), CXCL10(2), CXCL11(4), CXCL12(2), CXCL14(2), CXCL16(3), CXCL5(6), CXCL6(1), CXCL9(7), CXCR3(5), CXCR4(7), CXCR6(1), EDA(5), EDA2R(4), EDAR(8), EGF(8), EGFR(115), EPO(1), EPOR(2), FAS(9), FASLG(3), FLT1(43), FLT3(36), FLT3LG(1), FLT4(18), GDF5(13), GH1(5), GH2(6), GHR(12), HGF(17), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(10), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL15(1), IL15RA(1), IL17A(3), IL17B(1), IL17RA(8), IL17RB(8), IL18(3), IL18R1(16), IL18RAP(12), IL19(3), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL1RAP(7), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL25(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL8(6), IL9(2), INHBA(21), INHBB(3), INHBC(4), INHBE(3), KDR(42), KIT(161), KITLG(3), LEP(1), LEPR(21), LIF(1), LIFR(41), LTA(1), LTBR(5), MET(55), MPL(9), NGFR(5), OSM(4), OSMR(22), PDGFB(2), PDGFC(10), PDGFRA(64), PDGFRB(21), PF4(3), PLEKHO2(7), PPBP(6), PRL(4), PRLR(10), RELT(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TNF(2), TNFRSF10A(8), TNFRSF10B(8), TNFRSF10C(9), TNFRSF10D(2), TNFRSF11A(6), TNFRSF11B(7), TNFRSF13B(7), TNFRSF17(4), TNFRSF19(10), TNFRSF1A(4), TNFRSF1B(1), TNFRSF21(8), TNFRSF25(2), TNFRSF8(8), TNFRSF9(10), TNFSF10(3), TNFSF11(8), TNFSF12(2), TNFSF13(2), TNFSF13B(4), TNFSF14(4), TNFSF15(3), TNFSF4(6), TNFSF8(6), TPO(36), TSLP(3), VEGFA(5), VEGFB(3), VEGFC(15), XCL1(1), XCL2(4), XCR1(6)	118612917	2002	365	1727	655	465	483	234	486	314	20	0.0187	1.000	1.000
150	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	106	ACTN1(13), ACTN2(19), ACTN3(6), ACTN4(8), ARHGAP5(51), BCAR1(6), CDC42(3), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CTNNA1(28), CTNNA2(38), CTNNA3(28), CTNNB1(120), CTNND1(19), CXCL12(2), CXCR4(7), CYBB(6), ESAM(6), EZR(3), F11R(4), GNAI1(5), GNAI2(2), GNAI3(2), GRLF1(19), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), ITK(26), JAM2(2), JAM3(9), MAPK12(4), MAPK13(6), MAPK14(8), MLLT4(21), MMP2(18), MMP9(19), MSN(9), MYL2(2), MYL7(1), MYL9(3), NCF1(4), NCF2(10), NCF4(5), NOX1(4), NOX3(14), OCLN(2), PECAM1(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PLCG1(19), PLCG2(28), PRKCA(8), PRKCG(24), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAC1(2), RAC2(1), RAP1A(2), RAP1B(2), RAPGEF3(8), RAPGEF4(12), RASSF5(6), RHOA(13), RHOH(5), ROCK1(35), ROCK2(20), SIPA1(10), TXK(12), VASP(4), VAV1(24), VAV2(20), VAV3(30), VCAM1(15), VCL(10)	81647128	1604	365	1248	568	363	465	209	343	217	7	0.328	1.000	1.000
151	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(7), IFNG(3), IFNGR1(8), IFNGR2(5), IKBKB(9), JAK2(55), LIN7A(7), NFKB1(11), NFKBIA(1), RB1(139), RELA(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TP53(435), USH1C(15), WT1(32)	12365449	744	365	455	196	184	219	72	129	124	16	1.09e-05	1.000	1.000
152	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRB1(4), ADRB2(3), ADRB3(7), ANXA6(8), ARRB1(4), ARRB2(1), ATP1A4(21), ATP1B1(4), ATP1B2(4), ATP1B3(4), ATP2A2(17), ATP2A3(13), ATP2B1(19), ATP2B2(26), ATP2B3(17), CACNA1A(28), CACNA1B(40), CACNA1C(35), CACNA1D(29), CACNA1E(50), CACNA1S(34), CACNB1(6), CACNB3(3), CALM2(1), CALM3(1), CALR(2), CAMK1(9), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CASQ1(5), CASQ2(11), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), GJA1(9), GJA4(3), GJA5(7), GJB1(5), GJB2(1), GJB3(9), GJB4(6), GJB5(1), GJB6(3), GNA11(8), GNAI2(2), GNAI3(2), GNAO1(10), GNAQ(11), GNAZ(5), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG12(8), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), ITPR1(43), ITPR2(49), ITPR3(44), KCNB1(22), KCNJ3(11), KCNJ5(11), MIB1(13), MYCBP(1), NME7(9), PEA15(1), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLN(1), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SLC8A3(17), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1)	122538814	1742	364	1697	642	642	272	191	371	257	9	0.307	1.000	1.000
153	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(11), AKT2(8), AKT3(8), BCL2L1(1), CBL(45), CBLB(17), CBLC(3), CCND1(2), CCND2(3), CCND3(2), CISH(2), CLCF1(2), CNTF(3), CNTFR(10), CREBBP(81), CSF2RB(13), CSF3(3), CSF3R(19), EP300(56), EPO(1), EPOR(2), GH1(5), GH2(6), GHR(12), GRB2(11), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(10), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IFNG(3), IFNGR1(8), IFNGR2(5), IFNK(2), IL10(2), IL10RA(4), IL10RB(7), IL11(6), IL11RA(4), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL13(2), IL13RA1(6), IL13RA2(17), IL15(1), IL15RA(1), IL19(3), IL2(5), IL20(4), IL20RA(8), IL21(3), IL21R(14), IL22(2), IL22RA1(3), IL22RA2(3), IL23R(5), IL24(3), IL26(6), IL28A(3), IL28B(5), IL28RA(5), IL29(2), IL2RA(6), IL2RB(5), IL2RG(9), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL6ST(15), IL7(4), IL7R(13), IL9(2), IRF9(6), JAK1(22), JAK2(55), JAK3(31), LEP(1), LEPR(21), LIF(1), LIFR(41), MPL(9), MYC(5), OSM(4), OSMR(22), PIAS1(4), PIAS2(5), PIAS3(10), PIAS4(2), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIM1(4), PRL(4), PRLR(10), PTPN11(41), PTPN6(4), SOCS2(4), SOCS4(1), SOCS5(12), SOCS7(1), SOS1(16), SOS2(17), SPRED1(10), SPRED2(10), SPRY1(10), SPRY2(2), SPRY4(7), STAM(4), STAM2(4), STAT1(17), STAT2(12), STAT3(10), STAT4(13), STAT5A(10), STAT5B(20), STAT6(4), TPO(36), TSLP(3), TYK2(5)	96866624	1677	364	1320	583	338	492	240	388	211	8	0.115	1.000	1.000
154	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(31), ACTN1(13), ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGEF6(19), ARHGEF7(23), BCAR1(6), BRAF(125), CAV1(1), CDC42(3), CDKN2A(9), CSE1L(10), DOCK1(24), EPHB2(16), FYN(17), GRB2(11), GRB7(3), GRLF1(19), ILK(3), ITGA1(12), ITGA10(25), ITGA11(8), ITGA2(14), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGB3BP(3), MAP2K4(36), MAP3K11(12), MAPK1(3), MAPK10(18), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MRAS(4), MYLK(33), MYLK2(10), P4HB(6), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PIK3CA(344), PIK3CB(6), PKLR(12), PLCG1(19), PLCG2(28), PTEN(333), PTK2(24), RAF1(16), RALA(8), RHO(5), ROCK1(35), ROCK2(20), SHC1(14), SOS1(16), SOS2(17), SRC(3), TERF2IP(4), TLN1(23), TLN2(17), VASP(4), WAS(4), ZYX(5)	80902962	1771	362	1325	663	285	571	259	404	236	16	0.608	1.000	1.000
155	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM2(1), CALM3(1), CALML3(2), CALML6(1), CDS1(15), CDS2(10), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), FN3K(1), IMPA1(4), IMPA2(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5D(10), INPP5E(3), INPPL1(16), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), OCRL(21), PI4KA(29), PI4KB(5), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3C3(29), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PRKCA(8), PRKCG(24), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15)	81870157	1678	358	1286	603	344	559	231	329	203	12	0.396	1.000	1.000
156	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(12), CADM1(18), CADM3(15), CD2(7), CD22(17), CD226(6), CD274(5), CD276(6), CD28(5), CD34(7), CD4(4), CD40(7), CD40LG(10), CD58(15), CD6(6), CD80(6), CD86(2), CD8A(2), CD8B(4), CDH1(99), CDH15(3), CDH2(40), CDH3(9), CDH4(24), CDH5(8), CLDN1(1), CLDN10(14), CLDN11(4), CLDN14(1), CLDN15(1), CLDN16(8), CLDN17(13), CLDN18(6), CLDN19(3), CLDN2(3), CLDN20(1), CLDN4(1), CLDN6(3), CLDN7(2), CLDN8(8), CLDN9(2), CNTN1(31), CNTN2(13), CNTNAP1(15), CNTNAP2(39), CTLA4(5), ESAM(6), F11R(4), GLG1(15), HLA-A(26), HLA-B(22), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA1(33), HLA-DQA2(6), HLA-DQB1(2), HLA-DRA(12), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), ICAM1(4), ICAM2(6), ICAM3(3), ICOS(2), ICOSLG(5), ITGA4(20), ITGA6(16), ITGA8(20), ITGA9(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGB1(13), ITGB2(18), ITGB7(10), ITGB8(12), JAM2(2), JAM3(9), L1CAM(17), MAG(11), MPZ(2), MPZL1(7), NCAM1(18), NCAM2(29), NEGR1(4), NEO1(14), NFASC(41), NLGN1(21), NLGN2(5), NLGN3(11), NRCAM(21), NRXN1(46), NRXN2(24), NRXN3(35), OCLN(2), PDCD1(2), PDCD1LG2(2), PECAM1(4), PTPRC(36), PTPRF(23), PTPRM(48), PVR(2), PVRL1(9), PVRL2(5), PVRL3(5), SDC1(7), SDC2(7), SDC3(7), SDC4(1), SELE(13), SELL(5), SELP(15), SELPLG(19), SIGLEC1(19), SPN(6), VCAM1(15), VCAN(74)	95827709	1547	356	1394	543	427	245	175	378	298	24	0.334	1.000	1.000
157	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(14), ACTA2(3), ACTN2(19), ACTN3(6), ACTN4(8), DES(6), DMD(85), FAM48A(13), MYBPC1(12), MYBPC2(16), MYBPC3(15), MYH3(46), MYH6(34), MYH7(28), MYH8(47), MYL1(36), MYL2(2), MYL3(1), MYL4(4), MYL9(3), MYOM1(35), NEB(106), TMOD1(8), TNNC2(1), TNNI1(2), TNNI2(3), TNNI3(3), TNNT1(1), TNNT2(8), TNNT3(1), TPM1(5), TPM2(8), TPM3(7), TPM4(9), TTN(882), VIM(9)	80807506	1486	352	1327	427	407	294	195	424	146	20	8.30e-05	1.000	1.000
158	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(9), ACVR1B(31), ACVRL1(8), AKT1(11), AURKB(6), BMPR1A(18), BMPR2(49), BUB1(16), CDKL1(6), CDKL2(16), CDS1(15), CDS2(10), CLK1(10), CLK2(3), CLK4(17), COL4A3BP(5), CSNK2A1(7), CSNK2A2(7), CSNK2B(2), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), IMPA1(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MAP3K10(11), MOS(10), NEK1(20), NEK3(10), OCRL(21), PAK4(6), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CA(344), PIK3CB(6), PIK3CG(41), PIM2(1), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28), PLK3(3), PRKACA(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), PRKG1(18), RAF1(16), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KB1(9), STK11(38), TGFBR1(20), VRK1(7)	75307822	1423	351	1108	471	343	387	207	283	189	14	0.0665	1.000	1.000
159	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(14), ACTA2(3), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADM(5), ARRB1(4), ARRB2(1), ATF1(6), ATF2(7), ATF3(1), ATF4(4), ATF5(2), ATP2A2(17), ATP2A3(13), CACNB3(3), CALCA(5), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CNN1(5), CNN2(4), CORIN(21), CREB3(6), CRHR1(6), DGKZ(9), ETS2(5), FOS(5), GABPA(14), GABPB2(4), GBA2(15), GJA1(9), GNAQ(11), GNB1(3), GNB2(2), GNB3(6), GNB4(9), GNB5(3), GNG12(8), GNG3(2), GNG4(2), GNG7(2), GNGT1(1), GRK4(16), GRK5(13), GRK6(9), GSTO1(2), GUCA2B(3), GUCY1A3(33), IGFBP1(2), IGFBP2(3), IGFBP3(8), IGFBP4(4), IGFBP6(2), IL1B(5), IL6(7), ITPR1(43), ITPR2(49), ITPR3(44), JUN(2), MIB1(13), MYL2(2), MYL4(4), MYLK2(10), NFKB1(11), NOS1(31), NOS3(23), OXTR(3), PDE4B(13), PDE4D(9), PKIA(10), PKIB(3), PKIG(1), PLCB3(15), PLCD1(10), PLCG1(19), PLCG2(28), PRKACA(2), PRKACB(5), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PRKCD(15), PRKCE(6), PRKCH(14), PRKCQ(16), PRKCZ(4), PRKD1(35), RAMP1(2), RAMP2(2), RAMP3(7), RGS1(3), RGS10(4), RGS11(4), RGS14(6), RGS16(2), RGS17(8), RGS18(8), RGS19(1), RGS2(8), RGS20(10), RGS3(25), RGS4(10), RGS5(2), RGS6(7), RGS7(12), RGS9(12), RLN1(4), RYR1(70), RYR2(138), RYR3(84), SFN(1), SLC8A1(24), SP1(7), USP5(10), YWHAB(4), YWHAH(5), YWHAQ(1)	108403368	1520	351	1470	517	519	234	188	342	231	6	0.0398	1.000	1.000
160	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	154	ADORA1(18), ADORA2A(7), ADORA2B(5), ADORA3(15), ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), AGTR1(14), AGTR2(17), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCBP2(14), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CCR9(10), CCRL1(7), CCRL2(5), CHML(25), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), CMKLR1(8), CNR1(13), CNR2(1), CX3CR1(6), CXCR3(5), CXCR4(7), DRD1(9), DRD2(9), DRD3(6), DRD5(14), EDNRA(9), EDNRB(19), F2R(11), F2RL1(8), F2RL2(8), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GPR17(3), GPR173(3), GPR174(10), GPR3(3), GPR35(3), GPR37(15), GPR37L1(8), GPR4(7), GPR44(2), GPR50(9), GPR6(8), GPR63(7), GPR77(4), GPR83(7), GPR85(7), GPR87(12), GRPR(4), HCRTR1(1), HCRTR2(7), HRH1(4), HRH2(16), HRH3(1), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13), LHCGR(27), LTB4R(2), MAS1(3), MC1R(2), MC3R(14), MC4R(7), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(15), NMBR(4), NMUR1(7), NMUR2(19), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPN1SW(8), OPN3(7), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OR10A5(3), OR12D3(4), OR1C1(11), OR1F1(4), OR1Q1(5), OR2H1(5), OR5V1(18), OR7A5(6), OR7C1(15), OR8B8(6), OXTR(3), P2RY1(8), P2RY10(15), P2RY11(5), P2RY12(6), P2RY13(18), P2RY14(11), P2RY2(8), P2RY6(6), PPYR1(8), PTAFR(1), PTGDR(9), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), RGR(4), RHO(5), RRH(7), SSTR1(12), SSTR2(6), SSTR4(14), SUCNR1(6), TRHR(9)	76502535	1313	342	1174	473	468	246	162	302	134	1	0.00498	1.000	1.000
161	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2L1(1), CDC42(3), CDK2(5), CDKN1B(6), CDKN2A(9), CREB1(3), CREB3(6), CREB5(8), EBP(6), ERBB4(65), F2RL2(8), GAB1(15), GRB2(11), GSK3A(6), GSK3B(17), IFI27(19), IGF1(6), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), MET(55), MYC(5), NOLC1(9), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PARD3(13), PARD6A(2), PDK1(7), PIK3CA(344), PIK3CD(11), PPP1R13B(10), PREX1(27), PTEN(333), PTK2(24), PTPN1(11), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SLC2A4(8), SOS1(16), SOS2(17), TSC1(18), TSC2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	49966938	1399	342	1003	518	204	512	221	271	182	9	0.446	1.000	1.000
162	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(11), AKT2(8), AKT3(8), CASP8(20), CCL4(1), CD14(6), CD40(7), CD80(6), CD86(2), CHUK(27), CXCL10(2), CXCL11(4), CXCL9(7), FADD(1), FOS(5), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(10), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNAR1(7), IFNAR2(4), IFNB1(6), IKBKB(9), IKBKE(9), IKBKG(2), IL12A(2), IL12B(1), IL1B(5), IL6(7), IL8(6), IRAK1(6), IRAK4(8), IRF3(4), IRF5(6), JUN(2), LBP(8), LY96(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAP3K7(9), MAP3K8(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK9(13), MYD88(4), NFKB1(11), NFKB2(6), NFKBIA(1), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), RAC1(2), RELA(10), RIPK1(7), SPP1(4), STAT1(17), TBK1(12), TICAM1(15), TIRAP(5), TLR1(11), TLR2(12), TLR3(15), TLR4(18), TLR5(9), TLR6(14), TLR7(18), TLR8(20), TLR9(16), TNF(2), TOLLIP(5), TRAF3(12), TRAF6(4)	59298665	1151	335	902	374	215	336	170	267	158	5	0.0354	1.000	1.000
163	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(5), AKT1(11), AKT2(8), AKT3(8), ANGPTL2(14), ARHGAP1(3), ARHGAP4(7), ARHGEF11(24), BTK(12), CDC42(3), CFL1(2), CFL2(2), GDI1(1), GDI2(2), INPPL1(16), ITPR1(43), ITPR2(49), ITPR3(44), LIMK1(8), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3CG(41), PIK3R1(62), PITX2(2), PPP1R13B(10), PTEN(333), RACGAP1(5), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), SAG(5), WASF1(6), WASL(18)	46398755	1297	332	941	475	196	475	195	253	163	15	0.488	1.000	1.000
164	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(9), ACVR1B(31), ACVR1C(11), ACVR2A(66), ACVR2B(14), ACVRL1(8), AMHR2(4), BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BMPR1A(18), BMPR1B(15), BMPR2(49), CHRD(16), COMP(6), CREBBP(81), CUL1(17), DCN(9), E2F4(2), E2F5(6), EP300(56), FST(5), GDF5(13), GDF6(7), ID1(2), ID4(1), IFNG(3), INHBA(21), INHBB(3), INHBC(4), INHBE(3), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(3), MAPK3(4), MYC(5), NODAL(1), PITX2(2), PPP2CA(3), PPP2CB(4), PPP2R1A(14), PPP2R1B(4), PPP2R2A(8), PPP2R2B(12), PPP2R2C(13), RBL1(21), RBL2(24), RBX1(1), RHOA(13), ROCK1(35), ROCK2(20), RPS6KB1(9), RPS6KB2(6), SKP1(2), SMAD1(10), SMAD2(24), SMAD3(22), SMAD4(191), SMAD5(4), SMAD7(2), SMAD9(7), SMURF1(9), SMURF2(7), SP1(7), TFDP1(10), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), THBS1(14), THBS2(32), THBS3(9), THBS4(8), TNF(2), ZFYVE16(23), ZFYVE9(23)	66518207	1224	331	1010	382	325	238	137	253	247	24	0.0498	1.000	1.000
165	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(11), ASAH1(4), ATF1(6), BRAF(125), CAMP(1), CREB1(3), CREB3(6), CREB5(8), CREBBP(81), CRKL(5), DAG1(10), EGR1(14), EGR2(16), EGR3(6), EGR4(3), ELK1(4), FRS2(6), GNAQ(11), JUN(2), MAP1B(51), MAP2K4(36), MAPK1(3), MAPK10(18), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), NTRK1(17), OPN1LW(4), PIK3C2G(21), PIK3CA(344), PIK3CD(11), PIK3R1(62), PTPN11(41), RPS6KA3(16), SHC1(14), SRC(3), TERF2IP(4)	32221222	1019	327	691	389	146	351	157	236	123	6	0.570	1.000	1.000
166	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(11), AKT2(8), AKT3(8), BRD4(22), CAP1(5), CBL(45), CDC42(3), CDKN2A(9), F2RL2(8), FLOT1(7), FLOT2(2), GRB2(11), GSK3A(6), GSK3B(17), IGFBP1(2), INPPL1(16), IRS1(21), IRS4(36), LNPEP(23), MAPK1(3), MAPK3(4), PARD3(13), PARD6A(2), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PPYR1(8), PTEN(333), PTPN1(11), RAF1(16), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SERPINB6(4), SFN(1), SHC1(14), SLC2A4(8), SORBS1(15), SOS1(16), SOS2(17), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	38664488	1226	323	847	419	188	489	185	220	133	11	0.0188	1.000	1.000
167	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(4), IMPA2(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPP5B(5), INPP5E(3), INPPL1(16), IPMK(5), ISYNA1(6), ITGB1BP3(1), ITPK1(2), ITPKA(3), ITPKB(15), MINPP1(6), MIOX(3), OCRL(21), PI4KA(29), PI4KB(5), PIK3C3(29), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIP4K2A(7), PIP4K2B(5), PIP4K2C(5), PIP5K1A(7), PIP5K1B(4), PIP5K1C(14), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCD3(6), PLCD4(4), PLCE1(34), PLCG1(19), PLCG2(28), PLCZ1(19), PTEN(333), PTPMT1(7), SYNJ1(28), SYNJ2(15)	48729399	1216	320	869	449	214	455	181	235	122	9	0.492	1.000	1.000
168	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(14), CRKL(5), DOCK1(24), ELK1(4), FOS(5), GAB1(15), GRB2(11), HGF(17), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAP4K1(7), MAPK1(3), MAPK3(4), MAPK8(17), MET(55), PAK1(11), PIK3CA(344), PIK3R1(62), PTEN(333), PTK2(24), PTK2B(13), PTPN11(41), PXN(2), RAF1(16), RAP1A(2), RAP1B(2), RASA1(24), SOS1(16), SRC(3), STAT3(10)	30595431	1130	320	753	426	122	510	171	211	106	10	0.278	1.000	1.000
169	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(11), AKT2(8), AKT3(8), BCR(12), BTK(12), CD19(10), CDKN2A(9), DAPP1(3), FLOT1(7), FLOT2(2), GAB1(15), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), PDK1(7), PHF11(3), PIK3CA(344), PITX2(2), PLCG2(28), PPP1R13B(10), PREX1(27), PTEN(333), PTPRC(36), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SAG(5), SYK(8), TEC(10), VAV1(24)	36676407	1142	320	826	418	183	445	187	209	109	9	0.367	1.000	1.000
170	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(11), APOA1(3), APOA2(1), CD36(3), CITED2(3), CPT1B(14), CREBBP(81), DUSP1(7), EHHADH(15), EP300(56), FABP1(2), HSD17B4(9), JUN(2), LPL(12), MAPK1(3), MAPK3(4), ME1(14), MRPL11(1), MYC(5), NCOA1(15), NCOR1(35), NCOR2(44), NFKBIA(1), NR1H3(16), NR2F1(6), NRIP1(18), PDGFA(2), PIK3CA(344), PIK3R1(62), PPARA(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), PTGS2(10), RB1(139), RELA(10), RXRA(8), SP1(7), SRA1(3), STAT5A(10), STAT5B(20), TNF(2)	42050973	1048	315	723	365	177	368	139	188	166	10	0.145	1.000	1.000
171	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADCY9(22), ADK(7), ADSL(13), ADSS(8), ADSSL1(6), AK1(2), AK5(10), AK7(8), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), FHIT(1), GART(5), GDA(7), GMPR(9), GMPR2(3), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NPR1(18), NPR2(17), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT5(1), NUDT9(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE10A(19), PDE11A(16), PDE1A(10), PDE1C(19), PDE2A(10), PDE3B(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6D(2), PDE7A(8), PDE7B(6), PDE8A(6), PDE8B(17), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PPAT(8), PRIM1(5), PRIM2(3), PRPS1(9), PRPS1L1(4), PRPS2(6), PRUNE(4), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), XDH(19)	111775779	1263	308	1199	426	370	195	195	303	199	1	0.0996	1.000	1.000
172	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(11), AKT2(8), AKT3(8), BRAF(125), CAB39(2), EIF4B(5), FIGF(6), HIF1A(16), IGF1(6), MAPK1(3), MAPK3(4), PDPK1(4), PGF(4), PIK3CA(344), PIK3CB(6), PIK3CD(11), PIK3CG(41), PIK3R1(62), PIK3R2(3), PIK3R3(7), PIK3R5(5), PRKAA1(9), PRKAA2(20), RHEB(5), RICTOR(27), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), STK11(38), TSC1(18), TSC2(17), ULK2(14), ULK3(3), VEGFA(5), VEGFB(3), VEGFC(15)	33606906	941	308	634	332	156	329	141	206	105	4	0.168	1.000	1.000
173	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), BCR(12), BLNK(2), BTK(12), CD19(10), CD22(17), CR2(22), CSK(5), DAG1(10), FLOT1(7), FLOT2(2), GRB2(11), GSK3A(6), GSK3B(17), INPP5D(10), ITPR1(43), ITPR2(49), ITPR3(44), LYN(13), MAP4K1(7), MAPK1(3), MAPK3(4), NFATC2(12), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLCG2(28), PPP1R13B(10), PPP3CA(5), PPP3CB(11), PPP3CC(7), PTPRC(36), RAF1(16), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24)	47589464	964	307	731	303	210	307	153	180	110	4	0.00283	1.000	1.000
174	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(11), EIF4A2(12), EIF4G1(19), EIF4G2(16), EIF4G3(19), GHR(12), IRS1(21), MAPK1(3), MAPK14(8), MAPK3(4), MKNK1(4), PABPC1(8), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PRKCA(8), PTEN(333), RPS6KB1(9)	19190355	906	303	563	340	87	419	147	156	87	10	0.259	1.000	1.000
175	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM2(1), CALM3(1), CD3D(5), CD3E(2), CD3G(16), ELK1(4), FOS(5), FYN(17), GRB2(11), HRAS(4), JUN(2), LAT(3), LCK(9), MAP2K1(12), MAP2K4(36), MAP3K1(21), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PIK3CA(344), PIK3R1(62), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), PTPN7(4), RAC1(2), RAF1(16), RASA1(24), RELA(10), SHC1(14), SOS1(16), SYT1(14), VAV1(24), ZAP70(12)	31724041	813	303	549	263	157	286	121	133	112	4	0.0120	1.000	1.000
176	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(11), AKT2(8), AKT3(8), BAD(1), BTK(12), CDKN2A(9), DAPP1(3), GRB2(11), GSK3A(6), GSK3B(17), IARS(10), IGFBP1(2), INPP5D(10), PDK1(7), PIK3CA(344), PPP1R13B(10), PTEN(333), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KB1(9), SFN(1), SHC1(14), SOS1(16), SOS2(17), TEC(10), YWHAB(4), YWHAE(4), YWHAG(1), YWHAH(5), YWHAQ(1), YWHAZ(3)	24300500	941	301	619	349	108	419	147	169	89	9	0.188	1.000	1.000
177	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(12), CALM2(1), CALM3(1), ELK1(4), FCER1A(6), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP2K4(36), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PAK2(15), PIK3CA(344), PIK3R1(62), PLA2G4A(16), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAF1(16), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24)	28203638	762	298	518	242	131	283	124	134	86	4	0.00395	1.000	1.000
178	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(11), EIF4A2(12), EIF4B(5), EIF4G1(19), EIF4G2(16), EIF4G3(19), FKBP1A(2), MKNK1(4), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9), TSC1(18), TSC2(17)	18382092	890	298	550	336	88	422	136	144	90	10	0.220	1.000	1.000
179	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(7), EGF(8), EGFR(115), ELK1(4), FOS(5), GRB2(11), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP2K4(36), MAP3K1(21), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10)	26032731	812	296	555	276	132	311	132	150	82	5	0.0579	1.000	1.000
180	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(11), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), GSK3B(17), IGF1(6), IGF1R(22), INPPL1(16), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), PTEN(333), RPS6(3), RPS6KB1(9)	13571114	862	296	523	330	77	425	135	135	80	10	0.392	1.000	1.000
181	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(14), AGT(12), AKT1(11), CALM2(1), CALM3(1), CALR(2), CAMK1(9), CAMK1G(7), CAMK4(9), CREBBP(81), CSNK1A1(3), EDN1(3), ELSPBP1(2), F2(10), FGF2(5), FKBP1A(2), GATA4(4), GSK3B(17), HAND1(5), HAND2(2), HRAS(4), IGF1(6), LIF(1), MAP2K1(12), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MEF2C(15), MYH2(42), NFATC2(12), NFATC3(15), NFATC4(12), NPPA(1), PIK3CA(344), PIK3R1(62), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAF1(16), RPS6KB1(9), SYT1(14)	32957459	855	296	614	302	171	301	129	155	96	3	0.100	1.000	1.000
182	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(11), BCAR1(6), CDKN1B(6), GRB2(11), ILK(3), ITGB1(13), MAPK1(3), MAPK3(4), PDK2(9), PDPK1(4), PIK3CA(344), PIK3R1(62), PTEN(333), PTK2(24), SHC1(14), SOS1(16)	12839244	863	293	520	320	63	424	137	141	87	11	0.182	1.000	1.000
183	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(11), AKT2(8), AKT3(8), BPNT1(9), GRB2(11), ILK(3), MAPK1(3), MAPK3(4), PDK1(7), PIK3CA(344), PIK3CD(11), PTEN(333), PTK2B(13), RBL2(24), SHC1(14), SOS1(16)	13697746	819	290	497	308	67	393	136	145	69	9	0.421	1.000	1.000
184	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCR(12), BLNK(2), BTK(12), CD19(10), CSK(5), DAG1(10), EPHB2(16), GRB2(11), ITPKA(3), ITPKB(15), LYN(13), MAP2K1(12), MAP2K2(3), MAPK1(3), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PI3(3), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLCG2(28), PPP1R13B(10), RAF1(16), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SYK(8), VAV1(24)	34085306	752	290	517	237	155	268	124	133	69	3	0.00297	1.000	1.000
185	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(9), EIF1(2), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), ELAVL1(5), FLT1(43), FLT4(18), HIF1A(16), HRAS(4), KDR(42), NOS3(23), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTK2(24), PXN(2), SHC1(14), VHL(105)	22291426	783	290	500	293	101	333	128	130	88	3	0.379	1.000	1.000
186	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), JAK1(22), JUN(2), MAP2K1(12), MAP2K4(36), MAP3K1(21), MAPK3(4), MAPK8(17), PDGFA(2), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4), STAT1(17), STAT3(10), STAT5A(10)	24190074	755	288	506	245	118	281	121	145	83	7	0.0265	1.000	1.000
187	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5(3), CDK5R1(5), CFL1(2), CHN1(6), LIMK1(8), MAP3K1(21), MYL2(2), MYLK(33), NCF2(10), PAK1(11), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLD1(19), PPP1R12B(33), RAC1(2), RALBP1(8), RPS6KB1(9), TRIO(40), VAV1(24), WASF1(6)	24166713	714	288	475	240	105	267	118	132	86	6	0.0690	1.000	1.000
188	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), DAG1(10), DGKA(8), ETFA(5), GCA(1), ITGA9(13), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), MAP2K1(12), MAPK1(3), MAPK3(4), NR1I3(5), PAK1(11), PDE3A(21), PDE3B(10), PI3(3), PIK3C2G(21), PIK3CA(344), PIK3CD(11), PIK3R1(62), PLDN(1), PSME1(1), RIPK3(6), RPS4X(3), SGCB(7), VASP(4)	31891832	752	285	543	261	135	259	121	147	85	5	0.143	1.000	1.000
189	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(4), INPP1(8), INPP4A(12), INPP4B(13), INPP5A(6), INPPL1(16), ITPKA(3), ITPKB(15), MIOX(3), OCRL(21), PIK3C2A(23), PIK3C2B(29), PIK3C2G(21), PIK3CA(344), PIK3CB(6), PIK3CG(41), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), PLCD1(10), PLCG1(19), PLCG2(28)	29752016	694	283	480	246	134	240	123	134	62	1	0.281	1.000	1.000
190	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(7), GORASP1(13), IKBKG(2), MAP2K4(36), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), MAPK8IP1(6), MAPK8IP3(12), MAPK9(13), MAPKAPK5(7), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PIK3CA(344), PIK3CD(11), PIK3R1(62), SYT1(14), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4)	19458956	652	283	421	218	102	258	110	114	65	3	0.0462	1.000	1.000
191	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(11), AKT3(8), BCAR1(6), CAPN1(2), CAPN10(10), CAPN11(10), CAPN2(10), CAPN3(11), CAPN5(14), CAPN6(15), CAPN7(12), CAPN9(5), CAPNS1(4), CAV1(1), CAV2(4), CAV3(4), CDC42(3), CSK(5), DOCK1(24), FYN(17), GIT2(11), GRB2(11), ILK(3), ITGA10(25), ITGA11(8), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGA7(14), ITGA8(20), ITGA9(13), ITGAD(15), ITGAE(13), ITGAL(21), ITGAM(14), ITGAV(21), ITGAX(18), ITGB1(13), ITGB2(18), ITGB3(16), ITGB4(18), ITGB5(9), ITGB6(20), ITGB7(10), ITGB8(12), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAPK10(18), MAPK12(4), MAPK4(4), MAPK6(19), MAPK7(6), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PDPK1(4), PIK3R2(3), PTK2(24), PXN(2), RAC1(2), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(19), RHO(5), ROCK1(35), ROCK2(20), SDCCAG8(4), SEPP1(4), SHC1(14), SHC3(5), SORBS1(15), SOS1(16), SRC(3), TLN1(23), TNS1(39), VASP(4), VAV2(20), VAV3(30), VCL(10), ZYX(5)	89351139	1051	282	983	387	302	160	113	280	187	9	0.780	1.000	1.000
192	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(27), AKT1(11), BAD(1), BAX(16), BCL2(2), BCL2L1(1), CSF2RB(13), IGF1(6), IGF1R(22), IL3(6), KIT(161), KITLG(3), PIK3CA(344), PIK3R1(62), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), YWHAH(5)	14365102	715	281	450	264	101	333	109	104	65	3	0.360	1.000	1.000
193	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(51), DIAPH1(7), FYN(17), GSN(4), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PIK3CA(344), PIK3R1(62), PTK2(24), PXN(2), RAF1(16), ROCK1(35), SHC1(14), SRC(3), TLN1(23)	26259937	685	280	423	224	96	262	118	111	90	8	0.0245	1.000	1.000
194	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(27), AKT1(11), ASAH1(4), GNAI1(5), GNB1(3), GNGT1(1), ITGAV(21), ITGB3(16), MAPK1(3), MAPK3(4), PDGFA(2), PDGFRA(64), PIK3CA(344), PIK3R1(62), PLCB1(23), PRKCA(8), PTK2(24), RAC1(2), SMPD1(10), SMPD2(3), SPHK1(3), SRC(3)	18830928	643	280	415	236	90	262	111	118	56	6	0.230	1.000	1.000
195	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(64), ASH2L(7), C17orf79(1), CARM1(3), CTCFL(19), DOT1L(10), EED(2), EHMT1(11), EHMT2(10), EZH1(9), EZH2(51), FBXO11(15), HCFC1(13), HSF4(5), JMJD4(2), JMJD6(9), KDM6A(27), MEN1(32), MLL(58), MLL2(67), MLL3(88), MLL4(41), MLL5(32), NSD1(29), OGT(10), PAXIP1(22), PPP1CA(2), PPP1CB(6), PPP1CC(2), PRDM2(36), PRDM7(6), PRDM9(43), PRMT1(4), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), RBBP5(4), SATB1(17), SETD1A(21), SETD2(55), SETD7(9), SETD8(6), SETDB1(19), SETDB2(6), SETMAR(4), SMYD3(6), STK38(11), SUV39H1(4), SUV39H2(7), SUV420H1(17), SUV420H2(1), SUZ12(5), WHSC1(28), WHSC1L1(10)	78519652	994	279	871	309	259	220	89	224	190	12	0.177	1.000	1.000
196	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(27), AKT1(11), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CREB1(3), GNAS(39), GRB2(11), HRAS(4), MAPK1(3), MAPK14(8), MAPK3(4), PIK3CA(344), PIK3R1(62), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAC1(2), RPS6KA1(9), RPS6KA5(13), SOS1(16)	19542475	626	279	394	212	113	257	101	101	52	2	0.0502	1.000	1.000
197	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(11), CREB1(3), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NFKB1(11), PIK3CA(344), PIK3R1(62), RB1(139), RELA(10), SP1(7)	13584114	654	278	395	223	83	282	103	114	62	10	0.0245	1.000	1.000
198	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	27	AKT1(11), CABIN1(24), CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), HDAC5(14), IGF1(6), IGF1R(22), INSR(21), MAP2K6(5), MAPK14(8), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NFATC2(12), PIK3CA(344), PIK3R1(62), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYT1(14), YWHAH(5)	21577268	620	278	404	236	102	249	104	105	58	2	0.440	1.000	1.000
199	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(7), BRAF(125), CHUK(27), CREB1(3), DAXX(18), ELK1(4), FOS(5), GRB2(11), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K4(36), MAP2K5(6), MAP2K6(5), MAP3K1(21), MAP3K10(11), MAP3K11(12), MAP3K12(17), MAP3K13(21), MAP3K14(6), MAP3K2(9), MAP3K3(8), MAP3K4(53), MAP3K5(16), MAP3K6(11), MAP3K7(9), MAP3K8(4), MAP3K9(11), MAP4K1(7), MAP4K2(6), MAP4K3(19), MAP4K4(20), MAP4K5(4), MAPK1(3), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK3(4), MAPK4(4), MAPK6(19), MAPK7(6), MAPK8(17), MAPK9(13), MAPKAPK2(5), MAPKAPK3(6), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MKNK2(7), MYC(5), NFKB1(11), NFKBIA(1), PAK1(11), PAK2(15), RAC1(2), RAF1(16), RELA(10), RIPK1(7), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA4(6), RPS6KA5(13), RPS6KB1(9), RPS6KB2(6), SHC1(14), SP1(7), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8)	62542955	956	278	798	276	229	210	126	237	151	3	0.00356	1.000	1.000
200	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(11), AKT2(8), AKT3(8), BAD(1), BCL2(2), GRB2(11), GSK3A(6), GSK3B(17), IL4R(6), IRS1(21), JAK1(22), JAK3(31), MAP4K1(7), MAPK1(3), MAPK3(4), PDK1(7), PIK3CA(344), PIK3CD(11), PIK3R1(62), PPP1R13B(10), RAF1(16), SHC1(14), SOS1(16), SOS2(17), STAT6(4)	23446042	659	278	420	210	104	262	106	109	74	4	0.0189	1.000	1.000
201	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(11), BCL2(2), BCR(12), CRKL(5), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAP2K4(36), MAP3K1(21), MAPK3(4), MAPK8(17), MYC(5), PIK3CA(344), PIK3R1(62), RAF1(16), SOS1(16), STAT1(17), STAT5A(10), STAT5B(20)	18585748	687	277	444	222	100	282	117	118	64	6	0.00863	1.000	1.000
202	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(19), CD14(6), CD19(10), CD1A(6), CD1B(6), CD1C(5), CD1D(6), CD1E(19), CD2(7), CD22(17), CD33(3), CD34(7), CD36(3), CD37(4), CD38(5), CD3D(5), CD3E(2), CD3G(16), CD4(4), CD44(6), CD5(9), CD55(8), CD7(6), CD8A(2), CD8B(4), CD9(3), CR1(20), CR2(22), CSF1(5), CSF1R(16), CSF3(3), CSF3R(19), DNTT(13), EPO(1), EPOR(2), FCER2(2), FCGR1A(1), FLT3(36), FLT3LG(1), GP5(9), GP9(1), GYPA(8), HLA-DRA(12), HLA-DRB1(7), HLA-DRB5(4), IL11(6), IL11RA(4), IL1A(1), IL1B(5), IL1R1(7), IL1R2(10), IL2RA(6), IL3(6), IL4(5), IL4R(6), IL5RA(11), IL6(7), IL6R(8), IL7(4), IL7R(13), ITGA1(12), ITGA2(14), ITGA2B(8), ITGA3(17), ITGA4(20), ITGA5(18), ITGA6(16), ITGAM(14), ITGB3(16), KIT(161), KITLG(3), MME(27), MS4A1(7), TFRC(7), THPO(6), TNF(2), TPO(36)	54541969	853	276	751	293	217	208	110	206	107	5	0.0981	1.000	1.000
203	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(81), EP300(56), FYN(17), IL2RG(9), IL7(4), IL7R(13), JAK1(22), JAK3(31), LCK(9), NMI(4), PIK3CA(344), PIK3R1(62), PTK2B(13), STAT5A(10), STAT5B(20)	19280876	697	276	444	244	100	280	107	118	89	3	0.212	1.000	1.000
204	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(5), GHR(12), GRB2(11), HRAS(4), INSR(21), IRS1(21), JAK2(55), MAP2K1(12), MAPK1(3), MAPK3(4), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTPN6(4), RAF1(16), RPS6KA1(9), SHC1(14), SLC2A4(8), SOS1(16), SRF(4), STAT5A(10), STAT5B(20)	22334539	682	273	434	251	104	280	115	111	66	6	0.453	1.000	1.000
205	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	107	ADA(6), ADCY1(27), ADCY2(34), ADCY3(11), ADCY4(14), ADCY5(29), ADCY6(13), ADCY7(13), ADCY8(34), ADK(7), ADSL(13), ADSS(8), AK1(2), AK5(10), ALLC(6), AMPD1(19), AMPD2(21), AMPD3(12), ATIC(14), ATP1B1(4), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), CANT1(5), DCK(4), DGUOK(1), ENPP1(17), ENPP3(12), ENTPD1(5), ENTPD2(4), FHIT(1), GART(5), GDA(7), GMPS(16), GUCY1A2(28), GUCY1A3(33), GUCY1B3(12), GUCY2C(15), GUCY2D(15), GUCY2F(25), HPRT1(2), IMPDH1(4), IMPDH2(10), ITPA(6), NME1(1), NPR1(18), NPR2(17), NT5C(1), NT5E(7), NT5M(3), PAICS(3), PAPSS1(5), PAPSS2(7), PDE1A(10), PDE4A(12), PDE4B(13), PDE4C(9), PDE4D(9), PDE5A(14), PDE6B(11), PDE6C(12), PDE7B(6), PDE8A(6), PDE9A(11), PFAS(11), PKLR(12), PKM2(4), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), PPAT(8), PRPS1(9), PRPS1L1(4), PRPS2(6), PRUNE(4), RRM1(3), RRM2(5)	86149002	991	273	940	331	295	153	141	245	156	1	0.190	1.000	1.000
206	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(11), CCND1(2), CCNE1(6), CDK2(5), CDK4(4), CDK6(3), CDKN1A(2), CDKN1B(6), HRAS(4), MAPK1(3), MAPK3(4), NFKB1(11), NFKBIA(1), PAK1(11), PIK3CA(344), PIK3R1(62), RAC1(2), RAF1(16), RB1(139), RELA(10), TFDP1(10)	13838106	656	272	392	235	85	285	105	105	66	10	0.120	1.000	1.000
207	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(11), BAD(1), BCL2(2), BCL2L1(1), CBL(45), CFLAR(3), CRKL(5), FOS(5), GRB2(11), HRAS(4), IL2RA(6), IL2RB(5), IL2RG(9), IRS1(21), JAK1(22), JAK3(31), MAPK1(3), MAPK3(4), MYC(5), NMI(4), PIK3CA(344), PIK3R1(62), PPIA(1), PTPN6(4), RAF1(16), RPS6KB1(9), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8)	23628185	702	271	450	228	103	267	123	113	92	4	0.0505	1.000	1.000
208	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(27), ARHGEF1(15), F2(10), F2R(11), GNA12(7), GNA13(3), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), MAP3K7(9), PIK3CA(344), PIK3R1(62), PLCB1(23), PPP1R12B(33), PRKCA(8), PTK2B(13), ROCK1(35)	17531648	620	271	380	218	92	243	92	105	82	6	0.357	1.000	1.000
209	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(11), AKT2(8), AKT3(8), CISH(2), GRB2(11), IARS(10), IL13RA1(6), IL2RG(9), IL4(5), IL4R(6), INPP5D(10), JAK1(22), JAK2(55), JAK3(31), PI3(3), PIK3CA(344), PPP1R13B(10), RPS6KB1(9), SERPINA4(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT6(4), TYK2(5)	24712123	629	271	407	219	87	256	106	114	61	5	0.162	1.000	1.000
210	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IGF1(6), IGF1R(22), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PTPN11(41), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SRF(4)	16583740	636	270	392	212	92	263	106	108	64	3	0.0242	1.000	1.000
211	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), INSR(21), IRS1(21), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PIK3CA(344), PIK3R1(62), PTPN11(41), RAF1(16), RASA1(24), SHC1(14), SLC2A4(8), SOS1(16), SRF(4)	17063492	637	269	394	214	91	263	109	110	61	3	0.0255	1.000	1.000
212	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(7), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAPK3(4), MPL(9), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), RAF1(16), RASA1(24), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), THPO(6)	20895475	675	269	426	226	95	280	106	111	77	6	0.108	1.000	1.000
213	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(44), ABCA10(36), ABCA12(82), ABCA13(72), ABCA3(24), ABCA4(35), ABCA5(36), ABCA6(35), ABCA7(22), ABCA8(32), ABCA9(39), ABCB1(35), ABCB10(11), ABCB11(19), ABCB4(28), ABCB5(29), ABCB6(8), ABCB7(7), ABCB8(10), ABCB9(7), ABCC1(25), ABCC10(20), ABCC11(17), ABCC12(27), ABCC2(23), ABCC3(11), ABCC4(24), ABCC5(22), ABCC6(13), ABCC8(25), ABCC9(26), ABCD1(5), ABCD2(21), ABCD3(5), ABCD4(10), ABCG1(8), ABCG2(17), ABCG4(10), ABCG5(7), ABCG8(11), CFTR(21), TAP1(9), TAP2(16)	76282590	984	268	966	304	255	148	112	294	164	11	0.0126	1.000	1.000
214	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(8), ADAM17(13), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), CASP3(4), CDC42(3), CHUK(27), CSK(5), CXCL1(1), EGFR(115), F11R(4), GIT1(4), HBEGF(1), IGSF5(16), IKBKB(9), IKBKG(2), IL8(6), JAM2(2), JAM3(9), JUN(2), LYN(13), MAP2K4(36), MAP3K14(6), MAPK10(18), MAPK12(4), MAPK13(6), MAPK14(8), MAPK8(17), MAPK9(13), MET(55), NFKB1(11), NFKB2(6), NFKBIA(1), NOD1(10), PAK1(11), PLCG1(19), PLCG2(28), PTPN11(41), PTPRZ1(43), RAC1(2), RELA(10), SRC(3), TCIRG1(7), TJP1(25)	48194849	752	268	651	250	169	230	97	165	89	2	0.0789	1.000	1.000
215	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CXCL12(2), CXCR4(7), GNAI1(5), GNAQ(11), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), NFKB1(11), PIK3C2G(21), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), PTK2(24), PTK2B(13), PXN(2), RAF1(16), RELA(10)	18229328	588	266	372	221	87	241	104	97	56	3	0.407	1.000	1.000
216	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(11), BAD(1), BCL2L1(1), CASP9(6), CDC42(3), CHUK(27), ELK1(4), H2AFX(1), HRAS(4), MAP2K1(12), MAPK3(4), NFKB1(11), PIK3CA(344), PIK3R1(62), RAC1(2), RAF1(16), RALA(8), RALBP1(8), RALGDS(9), RELA(10), RHOA(13)	12874368	557	264	332	179	87	232	103	81	52	2	0.00625	1.000	1.000
217	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	88	ACTB(4), BAD(1), BCL2(2), CABIN1(24), CALM2(1), CALM3(1), CAMK2B(4), CAMK4(9), CD3E(2), CD3G(16), CD69(4), CDKN1A(2), CNR1(13), CREBBP(81), CSNK2A1(7), CSNK2B(2), CTLA4(5), EGR2(16), EGR3(6), EP300(56), FCER1A(6), FCGR3A(5), FOS(5), FOSL1(1), GATA3(17), GATA4(4), GRLF1(19), GSK3A(6), GSK3B(17), HRAS(4), ICOS(2), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL13(2), IL1B(5), IL2(5), IL2RA(6), IL3(6), IL4(5), IL6(7), IL8(6), ITK(26), KPNA5(12), MAPK14(8), MAPK8(17), MAPK9(13), MEF2A(7), MEF2D(3), MYF5(7), NCK2(5), NFAT5(6), NFATC2(12), NFATC3(15), NFATC4(12), NFKB2(6), NFKBIB(5), NFKBIE(5), NPPB(5), NUP214(22), OPRD1(6), P2RX7(13), PAK1(11), PIN1(2), PPIA(1), PPP3CB(11), PPP3CC(7), PPP3R1(4), PTPRC(36), RELA(10), RPL13A(1), SFN(1), SLA(8), SP1(7), SP3(13), TGFB1(2), TNF(2), TRAF2(8), TRPV6(20), VAV1(24), VAV2(20), VAV3(30), XPO5(8)	58564209	834	262	755	286	247	199	89	172	127	0	0.135	1.000	1.000
218	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	104	A4GNT(7), ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG6(5), ALG8(13), ALG9(8), B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT5(5), B4GALT7(2), C1GALT1(2), C1GALT1C1(4), CHPF(10), CHST1(10), CHST11(6), CHST12(6), CHST14(1), CHST2(13), CHST3(7), CHST4(8), CHSY1(14), DAD1(3), DDOST(4), DPAGT1(14), EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), FUT11(3), FUT8(11), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GANAB(13), GCNT1(9), GCNT3(6), GCNT4(14), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), NDST1(10), NDST2(10), NDST3(19), NDST4(13), OGT(10), RPN1(4), RPN2(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST6GAL1(3), ST6GALNAC1(6), STT3B(11), UST(12), WBSCR17(39), XYLT1(14), XYLT2(15)	72190533	902	262	839	326	307	150	94	206	145	0	0.826	1.000	1.000
219	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(21), HLA-A(26), IL18(3), ITGB1(13), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LAT(3), MAP2K1(12), MAPK3(4), PAK1(11), PIK3CA(344), PIK3R1(62), PTK2B(13), PTPN6(4), RAC1(2), SYK(8), VAV1(24)	12838145	569	262	351	191	68	235	94	101	66	5	0.139	1.000	1.000
220	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(11), BAD(1), GRB2(11), HRAS(4), IGF1R(22), IRS1(21), MAP2K1(12), MAPK1(3), MAPK3(4), PIK3CA(344), PIK3R1(62), RAF1(16), SHC1(14), SOS1(16), YWHAH(5)	12595172	546	261	318	176	74	233	101	82	53	3	0.0166	1.000	1.000
221	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(45), CD28(5), CD3D(5), CSK(5), CTLA4(5), DAG1(10), DTYMK(1), EPHB2(16), FBXW7(156), GRAP2(7), GRB2(11), ITK(26), ITPKA(3), ITPKB(15), LAT(3), LCK(9), LCP2(10), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PLCG1(19), PTPRC(36), RAF1(16), RASGRP1(8), RASGRP2(12), RASGRP3(9), RASGRP4(2), SOS1(16), SOS2(17), VAV1(24), ZAP70(12)	36408350	624	260	522	207	166	151	69	133	104	1	0.139	1.000	1.000
222	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(5), CD3D(5), CD3E(2), CD3G(16), CD80(6), CD86(2), CTLA4(5), GRB2(11), HLA-DRA(12), HLA-DRB1(7), ICOS(2), IL2(5), ITK(26), LCK(9), PIK3CA(344), PIK3R1(62), PTPN11(41)	8735712	560	258	316	186	58	256	95	90	56	5	0.0512	1.000	1.000
223	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), AKT1(11), ANXA1(4), CALM2(1), CALM3(1), GNAS(39), GNB1(3), GNGT1(1), NFKB1(11), NOS3(23), NPPA(1), NR3C1(11), PIK3CA(344), PIK3R1(62), RELA(10), SYT1(14)	11393777	539	258	304	187	83	236	91	79	48	2	0.111	1.000	1.000
224	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(11), DPM2(1), GRB2(11), HRAS(4), KLK2(4), NTRK1(17), PIK3CA(344), PIK3R1(62), PLCG1(19), PRKCA(8), SHC1(14), SOS1(16)	10659201	511	258	291	186	50	231	98	80	49	3	0.298	1.000	1.000
225	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(11), PIK3CA(344), PIK3R1(62), PLCB1(23), PLCG1(19), PRKCA(8), VAV1(24)	9053724	491	257	282	182	60	224	92	77	36	2	0.411	1.000	1.000
226	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(11), CREB1(3), GRB2(11), HRAS(4), MAPK1(3), MAPK3(4), MAPK7(6), MEF2A(7), MEF2C(15), MEF2D(3), NTRK1(17), PIK3CA(344), PIK3R1(62), PLCG1(19), RPS6KA1(9), SHC1(14)	12775174	532	256	318	194	65	236	98	79	51	3	0.384	1.000	1.000
227	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(9), BMP4(6), BMP5(9), BMP6(8), BMP7(15), BMP8A(4), BTRC(11), CSNK1A1(3), CSNK1A1L(9), CSNK1D(15), CSNK1E(9), CSNK1G1(3), CSNK1G2(1), CSNK1G3(7), DHH(4), FBXW11(13), GLI1(22), GLI2(28), GLI3(44), GSK3B(17), HHIP(16), IHH(5), LRP2(130), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), PTCH1(143), PTCH2(21), RAB23(4), SHH(3), SMO(13), STK36(20), SUFU(5), WNT1(7), WNT10A(3), WNT10B(6), WNT11(6), WNT16(9), WNT2(4), WNT2B(8), WNT3(7), WNT3A(4), WNT4(6), WNT5A(8), WNT5B(1), WNT7A(5), WNT7B(4), WNT8A(6), WNT8B(4), WNT9A(7), WNT9B(4)	38049670	715	256	617	261	227	157	82	139	107	3	0.464	1.000	1.000
228	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(7), DPM2(1), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), KLK2(4), MAP2K1(12), MAPK3(4), MAPK8(17), NGFR(5), PIK3CA(344), PIK3R1(62), PLCG1(19), RAF1(16), SHC1(14), SOS1(16)	12844340	547	256	324	185	72	237	97	87	51	3	0.0671	1.000	1.000
229	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(15), ALG6(5), CCKBR(16), CCR2(7), CCR3(11), CCR5(11), CELSR1(28), CELSR2(33), CELSR3(28), CHRM2(29), CHRM3(23), CIDEB(1), CXCR3(5), EDNRA(9), EMR2(11), EMR3(19), F2R(11), FSHR(19), GHRHR(2), GNRHR(9), GPR116(21), GPR132(6), GPR133(16), GPR143(4), GPR17(3), GPR18(5), GPR55(2), GPR56(6), GPR61(12), GPR77(4), GPR84(8), GPR88(4), GRM1(37), GRPR(4), HRH4(6), LGR6(9), LPHN2(30), LPHN3(30), NTSR1(5), OR2M4(17), OR8G1(3), OR8G2(9), P2RY11(5), P2RY13(18), PTGFR(8), SMO(13), SSTR2(6), TAAR5(10), TSHR(59), VN1R1(7)	40953007	659	255	571	222	194	147	65	162	90	1	0.131	1.000	1.000
230	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	82	AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHX58(6), ENPP1(17), ENPP3(12), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), G6PC(5), G6PC2(3), GAA(14), GANC(9), GBA(4), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), IFIH1(22), LYZL1(4), MGAM(26), MOV10L1(23), NUDT5(1), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SI(28), SKIV2L2(13), SMARCA2(22), SMARCA5(18), TREH(6), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UXS1(9)	85635782	923	252	856	275	257	158	110	220	175	3	0.0469	1.000	1.000
231	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(11), CAT(8), GH1(5), GHR(12), HRAS(4), IGF1(6), IGF1R(22), PIK3CA(344), PIK3R1(62), SHC1(14), SOD2(4)	8888486	492	252	278	179	59	215	93	78	44	3	0.253	1.000	1.000
232	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(11), BAD(1), CHRNB1(10), CHRNG(8), MUSK(15), PIK3CA(344), PIK3R1(62), PTK2(24), PTK2B(13), RAPSN(5), SRC(3), TERT(10), YWHAH(5)	10689274	511	251	303	186	62	225	95	78	49	2	0.370	1.000	1.000
233	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(11), BAD(1), CASP9(6), CHUK(27), GH1(5), GHR(12), NFKB1(11), NFKBIA(1), PDPK1(4), PIK3CA(344), PIK3R1(62), PPP2CA(3), RELA(10), YWHAH(5)	9817337	502	251	288	175	63	223	93	80	41	2	0.0467	1.000	1.000
234	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), CDC42(3), PAK1(11), PDGFRA(64), PIK3CA(344), PIK3R1(62), RAC1(2), WASL(18)	9475375	533	250	318	186	55	233	97	98	46	4	0.0525	1.000	1.000
235	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(11), AKT2(8), AKT3(8), CDKN1A(2), ELK1(4), GRB2(11), HRAS(4), MAP2K1(12), MAP2K2(3), NGFR(5), NTRK1(17), PIK3CA(344), PIK3CD(11), SHC1(14), SOS1(16)	10438025	470	250	276	177	59	198	99	82	31	1	0.387	1.000	1.000
236	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	68	A2M(25), BDKRB1(4), BDKRB2(6), C1QA(2), C1QB(2), C1QC(4), C1R(6), C1S(17), C2(10), C3(25), C3AR1(12), C4A(3), C4B(2), C4BPA(12), C4BPB(1), C5(25), C5AR1(8), C6(27), C7(11), C8A(14), C8B(23), C8G(1), C9(12), CD46(4), CD55(8), CFB(7), CFH(32), CFI(9), CPB2(11), CR1(20), CR2(22), F10(5), F11(8), F12(5), F13A1(15), F13B(12), F2(10), F2R(11), F3(2), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), KNG1(9), MASP1(23), MASP2(10), MBL2(3), PLAT(11), PLAU(7), PLAUR(9), PLG(27), PROC(3), PROS1(12), SERPINA1(9), SERPINA5(9), SERPINC1(8), SERPIND1(6), SERPINE1(10), SERPINF2(4), SERPING1(7), TFPI(9), THBD(3), VWF(36)	63684208	814	246	775	288	205	132	116	217	140	4	0.598	1.000	1.000
237	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(40), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ADIPOR1(2), ADIPOR2(6), AKT1(11), AKT2(8), AKT3(8), CAMKK1(2), CAMKK2(9), CD36(3), CHUK(27), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), G6PC(5), G6PC2(3), IKBKB(9), IKBKG(2), IRS1(21), IRS4(36), JAK1(22), JAK2(55), JAK3(31), LEP(1), LEPR(21), MAPK10(18), MAPK8(17), MAPK9(13), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NPY(6), PCK1(6), PCK2(6), POMC(4), PPARA(7), PPARGC1A(23), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7), PRKAG3(6), PRKCQ(16), PTPN11(41), RELA(10), RXRA(8), RXRB(8), RXRG(11), SLC2A1(7), SLC2A4(8), STAT3(10), STK11(38), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8), TYK2(5)	54515479	783	246	681	252	211	202	99	169	98	4	0.0323	1.000	1.000
238	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(11), AKT2(8), AKT3(8), ASAH1(4), BRAF(125), DAG1(10), DRD2(9), EGFR(115), EPHB2(16), GRB2(11), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), KCNJ3(11), KCNJ5(11), KCNJ9(8), MAPK1(3), PI3(3), PIK3CB(6), PITX2(2), PLCB1(23), PLCB2(11), PLCB3(15), PLCB4(23), RAF1(16), RGS20(10), SHC1(14), SOS1(16), SOS2(17), SRC(3), STAT3(10), TERF2IP(4)	38975867	677	246	555	229	163	176	80	180	76	2	0.253	1.000	1.000
239	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	62	AGTR1(14), AGTR2(17), ATP8A1(16), AVPR1A(15), AVPR1B(5), AVPR2(8), BDKRB1(4), BDKRB2(6), BRS3(5), C3AR1(12), CCKAR(9), CCKBR(16), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR6(3), CCR7(7), CCR8(7), CX3CR1(6), CXCR3(5), CXCR4(7), CXCR6(1), EDNRA(9), EDNRB(19), FPR1(8), FSHR(19), GALR1(5), GALT(3), GHSR(9), GNB2L1(2), GNRHR(9), GPR77(4), GRPR(4), LHCGR(27), MC1R(2), MC2R(8), MC3R(14), MC4R(7), MC5R(9), NMBR(4), NPY1R(6), NPY2R(12), NPY5R(7), NTSR1(5), NTSR2(9), OPRD1(6), OPRK1(14), OPRL1(4), OPRM1(14), OXTR(3), PPYR1(8), SSTR1(12), SSTR2(6), SSTR4(14), TAC4(4), TACR1(9), TACR2(4), TACR3(18), TRHR(9), TSHR(59)	33550979	588	242	516	214	189	134	64	148	53	0	0.137	1.000	1.000
240	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CDH1(99), CLDN1(1), CTNNB1(120), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), RHOA(13), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3)	34010172	626	239	512	221	132	166	79	134	110	5	0.279	1.000	1.000
241	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(31), ACTB(4), ACTG1(6), ARHGEF2(9), ARPC5(2), ARPC5L(4), CD14(6), CDC42(3), CDH1(99), CLDN1(1), CTNNB1(120), CTTN(5), EZR(3), FYN(17), HCLS1(16), ITGB1(13), KRT18(3), LY96(4), NCK1(1), NCK2(5), NCL(12), OCLN(2), PRKCA(8), RHOA(13), ROCK1(35), ROCK2(20), TLR4(18), TLR5(9), TUBA1A(2), TUBA1B(6), TUBA1C(4), TUBA3C(26), TUBA3D(4), TUBA3E(10), TUBA4A(12), TUBA8(5), TUBAL3(9), TUBB(2), TUBB1(6), TUBB2A(5), TUBB2B(4), TUBB2C(5), TUBB3(10), TUBB4(7), TUBB6(4), TUBB8(10), WAS(4), WASL(18), YWHAQ(1), YWHAZ(3)	34010172	626	239	512	221	132	166	79	134	110	5	0.279	1.000	1.000
242	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(237), BMPR1B(15), CCND2(3), CDK4(4), CDKN1B(6), DAZL(3), DMC1(7), EGR1(14), ESR2(8), FSHR(19), GJA4(3), INHA(6), LHCGR(27), MLH1(68), MSH5(8), NCOR1(35), NR5A1(5), NRIP1(18), PGR(16), PRLR(10), PTGER2(2), SMPD1(10), VDR(4), ZP2(16)	23733670	544	239	433	183	101	164	49	121	101	8	0.321	1.000	1.000
243	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(6), APAF1(27), ARHGDIB(5), BAG4(10), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP2(8), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), GSN(4), LMNA(1), LMNB1(11), LMNB2(3), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK8(17), MDM2(11), NFKB1(11), NFKBIA(1), NUMA1(26), PAK2(15), PRKCD(15), PRKDC(85), PSEN1(4), PSEN2(6), PTK2(24), RASA1(24), RB1(139), RELA(10), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8)	45065804	692	236	577	224	148	194	58	152	130	10	0.298	1.000	1.000
244	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(8), ANAPC10(2), ANAPC2(6), ANAPC4(15), ANAPC5(6), ANAPC7(6), BTRC(11), CDC16(6), CDC20(3), CDC23(12), CDC26(1), CDC27(21), CUL1(17), CUL2(15), CUL3(8), FBXW11(13), FBXW7(156), FZR1(4), ITCH(7), RBX1(1), SKP1(2), SKP2(3), SMURF1(9), SMURF2(7), TCEB1(1), TCEB2(1), UBA1(10), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(4), UBE2E2(4), UBE2E3(1), VHL(105), WWP1(21), WWP2(9)	28199328	503	234	385	184	124	129	57	110	80	3	0.494	1.000	1.000
245	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(2), CHUK(27), DAXX(18), EGF(8), EGFR(115), ETS1(10), ETS2(5), FOS(5), HOXA7(4), HRAS(4), IKBKB(9), JUN(2), MAP2K1(12), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K5(16), MAPK1(3), MAPK13(6), MAPK14(8), MAPK3(4), MAPK8(17), NFKB1(11), NFKBIA(1), PPP2CA(3), PRKCA(8), PRKCD(15), PRKCE(6), PRKCG(24), PRKCH(14), PRKCQ(16), RAF1(16), RELA(10), RIPK1(7), SP1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	32766348	507	227	443	182	136	149	67	104	50	1	0.254	1.000	1.000
246	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(115), ELK1(4), GNAS(39), GNB1(3), GNGT1(1), GRB2(11), HRAS(4), IGF1R(22), ITGB1(13), KLK2(4), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MYC(5), NGFR(5), PDGFRA(64), PPP2CA(3), PTPRR(16), RAF1(16), RPS6KA1(9), RPS6KA5(13), SHC1(14), SOS1(16), SRC(3), STAT3(10)	22414341	424	210	354	154	111	131	55	83	40	4	0.338	1.000	1.000
247	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(5), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CFLAR(3), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAF1(11), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MAP2K4(36), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), PTPN13(23), RB1(139), RIPK2(5), SPTAN1(30)	27173295	491	210	414	169	77	142	46	124	91	11	0.652	1.000	1.000
248	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	40	ADAM17(13), APH1A(2), CREBBP(81), CTBP1(5), CTBP2(14), DLL1(10), DLL3(7), DLL4(7), DTX1(6), DTX2(10), DTX3(3), DTX3L(11), DTX4(8), DVL2(12), DVL3(10), EP300(56), HDAC1(5), HDAC2(8), HES1(2), JAG1(16), LFNG(6), MAML1(12), MAML2(9), MAML3(4), MFNG(1), NCOR2(44), NCSTN(6), NOTCH2(35), NOTCH3(31), NOTCH4(20), NUMB(10), NUMBL(6), PSEN1(4), PSEN2(6), PSENEN(2), PTCRA(5), RBPJ(21), RBPJL(11), RFNG(1), SNW1(10)	38604140	530	209	467	232	154	101	68	91	115	1	0.987	1.000	1.000
249	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(6), CDC34(2), CDK2(5), CUL1(17), FBXW7(156), RB1(139), TFDP1(10)	5993566	335	206	218	121	72	102	18	70	64	9	0.377	1.000	1.000
250	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(42), AR(26), ESR1(21), ESR2(8), ESRRA(35), HNF4A(12), NPM1(3), NR0B1(11), NR1D1(8), NR1D2(10), NR1H2(2), NR1H3(16), NR1I2(3), NR1I3(5), NR2C2(11), NR2E1(13), NR2F1(6), NR2F2(11), NR3C1(11), NR4A1(3), NR4A2(16), NR5A1(5), NR5A2(9), PGR(16), PPARA(7), PPARD(5), PPARG(4), RARA(6), RARB(20), RARG(10), ROR1(23), RORA(6), RORC(6), RXRA(8), RXRB(8), RXRG(11), THRA(6), THRB(14), VDR(4)	27247682	441	206	385	139	139	72	49	94	85	2	0.263	1.000	1.000
251	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(5), BAG4(10), CASP2(8), CASP3(4), CASP8(20), CRADD(4), DFFA(6), DFFB(2), FADD(1), JUN(2), LMNA(1), LMNB1(11), LMNB2(3), MADD(26), MAP2K4(36), MAP3K1(21), MAP3K7(9), MAPK8(17), PAK1(11), PAK2(15), PRKDC(85), RB1(139), RIPK1(7), SPTAN1(30), TNF(2), TNFRSF1A(4), TRAF2(8)	25488633	487	206	405	162	94	135	40	113	93	12	0.450	1.000	1.000
252	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(21), CALR(2), CANX(5), CD4(4), CD74(3), CD8A(2), CD8B(4), CIITA(18), CREB1(3), CTSB(6), CTSL1(8), CTSS(4), HLA-A(26), HLA-B(22), HLA-C(13), HLA-DMA(4), HLA-DMB(5), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(7), HLA-DQA1(33), HLA-DQA2(6), HLA-DQB1(2), HLA-DRA(12), HLA-DRB1(7), HLA-DRB5(4), HLA-E(4), HLA-F(5), HLA-G(13), HSP90AA1(9), HSP90AB1(4), HSPA5(5), IFI30(3), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(10), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), KIR2DL1(10), KIR2DL3(20), KIR2DL4(5), KIR2DS4(4), KIR3DL1(10), KIR3DL2(7), KIR3DL3(11), KLRC1(2), KLRC2(2), KLRC3(8), KLRC4(4), KLRD1(3), LGMN(3), LTA(1), NFYA(5), NFYB(2), NFYC(10), PDIA3(10), PSME1(1), RFX5(15), RFXANK(1), RFXAP(5), TAP1(9), TAP2(16), TAPBP(6)	29146509	499	205	416	130	78	82	64	120	124	31	0.0685	1.000	1.000
253	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B1(15), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), CARM1(3), DBH(9), DCT(22), DDC(5), ECH1(2), ESCO1(22), ESCO2(18), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HEMK1(1), HGD(6), HPD(7), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), MYST3(34), MYST4(33), NAT6(2), PNMT(3), PNPLA3(6), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SH3GLB1(6), TAT(16), TPO(36), TYR(12), TYRP1(6), WBSCR22(2)	39806046	489	203	434	176	137	96	56	126	73	1	0.509	1.000	1.000
254	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(14), AKT1(11), BDKRB2(6), CALM2(1), CALM3(1), CAV1(1), CHRM1(4), CHRNA1(12), FLT1(43), FLT4(18), KDR(42), NOS3(23), PDE2A(10), PDE3A(21), PDE3B(10), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKG1(18), PRKG2(12), RYR2(138), SLC7A1(6), SYT1(14), TNNI1(2)	25500072	442	203	424	158	119	97	52	112	60	2	0.395	1.000	1.000
255	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CAT(8), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADHA(12), KMO(16), KYNU(9), MAOA(7), MAOB(9), SDS(3), TDO2(11), TPH1(4), WARS(4), WARS2(7)	37713531	481	203	450	142	157	91	52	128	52	1	0.0183	1.000	1.000
256	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1C1(2), AKR1C2(3), AKR1C3(2), AKR1C4(12), ALDH1A3(20), ALDH3A1(7), ALDH3B1(15), ALDH3B2(8), CYP1A1(10), CYP1A2(11), CYP1B1(14), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2F1(7), CYP2S1(8), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHDH(5), EPHX1(12), GSTA1(6), GSTA2(3), GSTA3(7), GSTA4(2), GSTA5(8), GSTM1(1), GSTM2(3), GSTM3(6), GSTM4(6), GSTM5(10), GSTO2(3), GSTP1(1), GSTT1(2), GSTZ1(5), MGST1(2), MGST2(2), MGST3(1), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9)	38946071	489	202	426	127	118	99	48	134	89	1	0.00562	1.000	1.000
257	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(7), CDC40(7), CLK2(3), CLK3(8), CLK4(17), COL2A1(20), CPSF1(15), CPSF2(10), CPSF3(9), CPSF4(5), CSTF1(5), CSTF2(2), CSTF2T(14), CSTF3(13), DDIT3(5), DDX1(15), DDX20(7), DHX15(10), DHX16(20), DHX38(14), DHX8(16), DHX9(13), DICER1(25), DNAJC8(5), FUS(2), GIPC1(4), LSM2(1), METTL3(6), NCBP1(12), NCBP2(2), NONO(13), NUDT21(1), NXF1(11), PABPN1(2), PAPOLA(8), PHF5A(1), POLR2A(14), PPM1G(4), PRPF18(5), PRPF3(9), PRPF4(10), PRPF4B(22), PRPF8(19), PSKH1(2), PTBP1(4), PTBP2(14), RBM17(6), RBM5(15), RNGTT(7), RNMT(6), RNPS1(2), SF3A1(11), SF3A2(5), SF3A3(1), SF3B1(18), SF3B2(10), SF3B4(9), SFRS14(2), SFRS4(2), SNRPA(3), SNRPA1(2), SNRPB(3), SNRPB2(3), SNRPD1(2), SNRPD3(2), SNRPE(2), SNRPN(5), SNURF(1), SPOP(3), SRPK1(9), SRPK2(12), SRRM1(18), SUPT5H(20), TXNL4A(2), U2AF1(4), U2AF2(8), XRN2(12)	71972919	636	201	592	202	180	92	66	163	134	1	0.766	1.000	1.000
258	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(2), AANAT(2), ABP1(4), ACAT1(7), ACAT2(9), ACMSD(8), AFMID(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), AOX1(15), CARM1(3), CAT(8), CYP1A1(10), CYP1A2(11), CYP1B1(14), DDC(5), ECHS1(4), EHHADH(15), GCDH(8), HAAO(4), HADH(2), HADHA(12), HEMK1(1), HSD17B10(3), HSD17B4(9), INMT(4), KMO(16), KYNU(9), LCMT1(1), LCMT2(6), LNX1(19), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), NFX1(11), OGDH(14), OGDHL(16), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), TDO2(11), TPH1(4), TPH2(12), WARS(4), WARS2(7), WBSCR22(2)	41182103	458	200	427	155	136	81	58	122	61	0	0.277	1.000	1.000
259	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(7), AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ENTPD3(7), ENTPD4(19), ENTPD5(3), ENTPD6(4), ENTPD8(3), ITPA(6), NME1(1), NME4(1), NME6(4), NME7(9), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), PNPT1(15), POLA1(15), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2), PRIM1(5), PRIM2(3), RFC5(8), RRM1(3), RRM2(5), RRM2B(5), TK1(2), TK2(3), TXNRD1(9), TXNRD2(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UPB1(9), UPP1(5), UPP2(6), UPRT(7)	56169458	575	199	549	165	152	92	91	153	87	0	0.00515	1.000	1.000
260	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(12), AGTR1(14), ATF2(7), CALM2(1), CALM3(1), EGFR(115), ELK1(4), GNAQ(11), GRB2(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K4(36), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), MEF2A(7), MEF2C(15), MEF2D(3), PAK1(11), PRKCA(8), PTK2(24), PTK2B(13), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SRC(3), SYT1(14)	23296369	424	196	371	147	88	121	52	105	56	2	0.325	1.000	1.000
261	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	62	ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), CDS1(15), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CHPT1(4), CRLS1(1), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), ESCO1(22), ESCO2(18), ETNK1(3), ETNK2(12), GNPAT(19), GPAM(5), GPD1(3), GPD1L(5), GPD2(11), LCAT(4), LYPLA1(1), LYPLA2(1), MYST3(34), MYST4(33), NAT6(2), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3), PTDSS1(14), SH3GLB1(6)	43812988	506	196	453	189	145	85	68	133	74	1	0.777	1.000	1.000
262	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(14), ADCY4(14), ADCY6(13), ADCY8(34), CACNA1A(28), CACNA1B(40), GNAS(39), GNAT3(4), GNB1(3), GNB3(6), GNG3(2), GRM4(15), ITPR3(44), KCNB1(22), PDE1A(10), PLCB2(11), PRKACA(2), PRKACB(5), PRKACG(9), PRKX(3), SCNN1A(8), SCNN1B(8), SCNN1G(12), TAS1R1(13), TAS1R2(22), TAS2R1(5), TAS2R10(10), TAS2R13(9), TAS2R14(2), TAS2R16(7), TAS2R3(6), TAS2R38(7), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(3), TAS2R46(1), TAS2R5(4), TAS2R50(10), TAS2R60(4), TAS2R7(4), TAS2R8(9), TAS2R9(3), TRPM5(5)	35670165	485	195	463	178	183	65	47	112	77	1	0.698	1.000	1.000
263	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(7), ACADL(6), ACADM(12), ACOX1(11), ACOX2(8), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADIPOQ(8), ANGPTL4(1), APOA1(3), APOA2(1), APOA5(6), AQP7(9), CD36(3), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP27A1(4), CYP4A11(8), CYP4A22(13), CYP7A1(14), CYP8B1(10), DBI(2), EHHADH(15), FABP1(2), FABP2(9), FABP3(2), FABP4(3), FABP5(2), FABP6(2), FABP7(1), FADS2(12), GK(5), GK2(16), HMGCS2(6), ILK(3), LPL(12), ME1(14), MMP1(6), NR1H3(16), OLR1(10), PCK1(6), PCK2(6), PDPK1(4), PLTP(12), PPARA(7), PPARD(5), PPARG(4), RXRA(8), RXRB(8), RXRG(11), SCD(4), SCP2(6), SLC27A1(4), SLC27A2(7), SLC27A4(3), SLC27A5(9), SLC27A6(20), SORBS1(15), UBC(7), UCP1(8)	44630667	517	192	473	144	163	73	75	132	74	0	0.00366	1.000	1.000
264	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(6), BAD(1), BRAF(125), CREB1(3), CREB3(6), CREB5(8), DUSP4(6), DUSP6(7), DUSP9(9), EEF2K(11), GRB2(11), MAP2K1(12), MAP2K2(3), MAP3K8(4), MAPK1(3), MAPK3(4), MKNK1(4), MKNK2(7), MOS(10), NFKB1(11), RAP1A(2), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), SHC1(14), SOS1(16), SOS2(17), TRAF3(12)	20384970	362	187	270	115	68	98	40	105	50	1	0.159	1.000	1.000
265	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(32), CARM1(3), CCND1(2), CREBBP(81), EP300(56), ERCC3(19), ESR1(21), GRIP1(15), GTF2A1(6), GTF2E1(13), GTF2F1(7), HDAC1(5), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(14), HDAC6(9), MEF2C(15), NCOR2(44), NR0B1(11), NRIP1(18), PELP1(11), POLR2A(14), SRA1(3), TBP(2)	31101277	431	186	375	191	113	89	45	82	102	0	0.997	1.000	1.000
266	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	90	ANK2(84), B3GALT4(4), CDR1(8), DGKI(22), FAU(2), IL6ST(15), MRPL19(4), PIGK(12), RPL10(3), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL22(25), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL39(2), RPL3L(6), RPL4(4), RPL5(6), RPL6(4), RPL7(4), RPL7A(1), RPL8(3), RPL9(4), RPLP0(3), RPLP1(1), RPS10(2), RPS11(2), RPS13(2), RPS14(2), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS4X(3), RPS5(2), RPS6(3), RPS6KA1(9), RPS6KA2(25), RPS6KA3(16), RPS6KA6(18), RPS6KB1(9), RPS6KB2(6), RPS7(1), RPS9(3), RPSA(1), SLC36A2(6), TBC1D10C(9), TSPAN9(5), UBA52(3), UBB(3), UBC(7)	34287255	412	186	367	110	102	77	52	95	84	2	0.117	1.000	1.000
267	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(237), CDC25A(11), CDC25B(11), CDC25C(6), CHEK1(11), MYT1(25), WEE1(15), YWHAH(5)	9731376	321	185	248	108	54	113	24	74	48	8	0.307	1.000	1.000
268	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(12), AGTR2(17), CALM2(1), CALM3(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CDK5(3), F2(10), FYN(17), GNA11(8), GNAI1(5), GNB1(3), GNGT1(1), GRB2(11), HRAS(4), JAK2(55), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), MAPT(11), MYLK(33), PLCG1(19), PRKCA(8), PTK2B(13), RAF1(16), SHC1(14), SOS1(16), STAT1(17), STAT3(10), STAT5A(10), SYT1(14)	28812736	403	184	345	147	102	110	47	82	58	4	0.605	1.000	1.000
269	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AGK(7), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CEL(13), DAK(8), DGAT1(5), DGAT2(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKI(22), DGKZ(9), GK(5), GK2(16), GLA(7), GLB1(9), GPAM(5), LCT(46), LIPA(3), LIPC(6), LIPF(3), LIPG(4), LPL(12), MGLL(2), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PNPLA3(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	39025910	468	184	432	178	131	73	67	144	52	1	0.655	1.000	1.000
270	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(45), CSF1R(16), EGF(8), EGFR(115), GRB2(11), MET(55), PDGFRA(64), PRKCA(8), SH3GLB1(6), SH3GLB2(6), SH3KBP1(8), SRC(3)	13825164	345	182	298	143	51	143	48	78	23	2	0.671	1.000	1.000
271	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(7), ACSS2(10), ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B1(15), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), G6PC2(3), GALM(3), GAPDH(2), GAPDHS(3), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	39106462	442	179	394	146	137	80	44	113	68	0	0.233	1.000	1.000
272	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), HSD3B7(3), NSD1(29), OGDH(14), OGDHL(16), PIPOX(9), PLOD1(8), PLOD2(10), PLOD3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SETD1A(21), SETD7(9), SETDB1(19), SHMT1(7), SHMT2(5), SPCS1(3), SPCS3(2), SUV39H1(4), SUV39H2(7), TMLHE(6)	38267916	398	176	366	120	135	63	41	92	67	0	0.0981	1.000	1.000
273	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(7), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ACSM1(10), AKR1B10(3), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH7A1(8), ALDH9A1(4), BDH1(4), BDH2(2), DDHD1(51), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADH(2), HADHA(12), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), HSD3B7(3), ILVBL(9), L2HGDH(3), OXCT1(3), OXCT2(3), PDHA1(8), PDHA2(17), PDHB(3), PLA1A(10), PPME1(2), PRDX6(5), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	28245425	361	176	285	101	104	56	39	76	86	0	0.0825	1.000	1.000
274	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(35), ATP4A(20), ATP4B(3), ATP5A1(7), ATP5B(6), ATP5C1(7), ATP5F1(3), ATP5G2(2), ATP5G3(1), ATP5I(1), ATP5J2(4), ATP5L(2), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), COX10(6), COX15(8), COX17(1), COX4I1(5), COX4I2(4), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6B2(1), COX6C(3), COX7A1(1), COX7A2(2), COX7B2(1), COX8A(2), COX8C(1), CYC1(4), LHPP(6), NDUFA1(2), NDUFA10(11), NDUFA12(4), NDUFA13(3), NDUFA2(1), NDUFA3(2), NDUFA4(3), NDUFA4L2(2), NDUFA5(1), NDUFA7(1), NDUFA8(1), NDUFA9(8), NDUFAB1(2), NDUFB1(1), NDUFB10(6), NDUFB11(1), NDUFB2(3), NDUFB3(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFB8(3), NDUFB9(4), NDUFC1(1), NDUFC2(2), NDUFS1(16), NDUFS2(6), NDUFS3(4), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFV1(5), NDUFV2(3), NDUFV3(5), PPA1(3), PPA2(5), SDHA(14), SDHB(3), SDHD(4), TCIRG1(7), UQCRB(2), UQCRC1(4), UQCRC2(13), UQCRFS1(3), UQCRH(1)	38676698	450	175	409	130	145	90	54	86	75	0	0.00779	1.000	1.000
275	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	40	ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), ASCC3(34), ATP13A2(14), DDX18(17), DDX19A(6), DDX23(22), DDX4(8), DDX41(7), DDX47(11), DDX50(10), DDX51(4), DDX52(4), DDX54(10), DDX55(11), DDX56(8), DHFR(1), DHX58(6), ENTPD7(7), EP400(56), ERCC2(10), ERCC3(19), FPGS(4), GGH(2), IFIH1(22), MOV10L1(23), NUDT5(1), QDPR(2), RAD54B(13), RAD54L(11), RUVBL2(5), SETX(47), SKIV2L2(13), SMARCA2(22), SMARCA5(18), SPR(7)	42240555	478	174	432	156	149	83	53	106	85	2	0.327	1.000	1.000
276	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), BCR(12), CAPN1(2), CAPNS1(4), CAPNS2(4), CAV1(1), CRKL(5), CSK(5), FYN(17), GRB2(11), HRAS(4), ITGA1(12), ITGB1(13), JUN(2), MAP2K1(12), MAP2K2(3), MAPK1(3), MAPK3(4), MAPK8(17), PPP1R12B(33), PTK2(24), PXN(2), RAF1(16), RAP1A(2), ROCK1(35), SHC1(14), SOS1(16), SRC(3), TLN1(23), VCL(10), ZYX(5)	30770205	372	173	318	123	105	67	43	78	73	6	0.381	1.000	1.000
277	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), F10(5), F11(8), F12(5), F2(10), F2R(11), F5(37), F8(50), F9(20), FGA(23), FGB(6), FGG(7), KLKB1(16), PROC(3), PROS1(12), SERPINC1(8), SERPING1(7)	31265399	375	172	347	149	83	72	55	99	64	2	0.679	1.000	1.000
278	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	21	CHUK(27), CREBBP(81), DUSP1(7), EP300(56), IKBKB(9), IL1B(5), IL8(6), MAP2K3(11), MAP2K6(5), MAP3K14(6), MAP3K7(9), MAPK14(8), MYD88(4), NFKB1(11), NFKBIA(1), NR3C1(11), RELA(10), TGFBR1(20), TGFBR2(26), TLR2(12), TNF(2)	20033236	327	172	281	114	87	98	34	63	44	1	0.294	1.000	1.000
279	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(5), ARHGAP1(3), ARHGAP4(7), ARHGAP5(51), ARHGAP6(11), ARHGEF1(15), ARHGEF11(24), ARHGEF5(7), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), BAIAP2(7), CFL1(2), DIAPH1(7), GSN(4), LIMK1(8), MYL2(2), MYLK(33), OPHN1(11), PIP5K1A(7), PIP5K1B(4), PPP1R12B(33), ROCK1(35), SRC(3), TLN1(23), VCL(10)	31831267	336	172	270	93	87	67	30	66	81	5	0.179	1.000	1.000
280	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(45), EGF(8), EGFR(115), GRB2(11), HRAS(4), MAP2K1(12), MAPK1(3), MAPK3(4), PTPRB(21), RAF1(16), RASA1(24), SHC1(14), SOS1(16), SPRY1(10), SPRY2(2), SPRY4(7), SRC(3)	16287639	315	172	267	109	64	107	48	60	35	1	0.195	1.000	1.000
281	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), CEL(13), DGAT1(5), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), GK(5), GLA(7), GLB1(9), LCT(46), LIPC(6), LIPF(3), LIPG(4), LPL(12), PNLIP(11), PNLIPRP1(4), PNLIPRP2(6), PPAP2A(2), PPAP2B(2), PPAP2C(3)	31815098	404	171	370	144	112	73	57	115	46	1	0.347	1.000	1.000
282	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTG2(6), ACTR2(2), ACTR3(5), AKT1(11), ANGPTL2(14), CDC42(3), CFL1(2), CFL2(2), FLNA(31), FLNC(39), FSCN1(5), FSCN3(6), GDI1(1), GDI2(2), LIMK1(8), MYH2(42), MYLK(33), MYLK2(10), PAK1(11), PAK2(15), PAK3(20), PAK4(6), PAK6(4), PAK7(27), PFN2(4), RHO(5), ROCK1(35), ROCK2(20), RPS4X(3), VASP(4), WASF1(6), WASL(18)	30035145	406	171	373	137	120	63	49	89	80	5	0.286	1.000	1.000
283	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(22), AMY1A(1), AMY1B(1), AMY2A(6), AMY2B(5), ENPP1(17), ENPP3(12), G6PC(5), GAA(14), GANAB(13), GBA3(3), GBE1(10), GCK(6), GPI(6), GUSB(4), GYS1(6), GYS2(17), HK1(13), HK2(7), HK3(22), MGAM(26), PGM1(10), PGM3(7), PYGB(15), PYGL(8), PYGM(12), SI(28), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UXS1(9)	40341344	392	171	375	118	112	71	49	83	76	1	0.123	1.000	1.000
284	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B1(15), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	33261013	396	170	348	124	121	80	39	99	57	0	0.0997	1.000	1.000
285	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(5), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPS(6), CDS1(15), CDS2(10), CHAT(17), CHKA(6), CHKB(3), CLC(3), CPT1B(14), DGKA(8), DGKB(24), DGKD(24), DGKE(7), DGKG(8), DGKH(22), DGKZ(9), ETNK1(3), GNPAT(19), GPD1(3), GPD2(11), LCAT(4), LGALS13(5), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(7), PCYT1A(5), PCYT1B(7), PEMT(2), PISD(8), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLCB2(11), PLCG1(19), PLCG2(28), PPAP2A(2), PPAP2B(2), PPAP2C(3)	32486698	381	170	343	150	129	56	50	89	57	0	0.850	1.000	1.000
286	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B1(15), ALDH3B2(8), ALDH9A1(4), ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GCK(6), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHB(8), LDHC(4), PDHA1(8), PDHA2(17), PDHB(3), PFKM(5), PFKP(16), PGAM1(4), PGK1(3), PGM1(10), PGM3(7), PKLR(12), PKM2(4), TPI1(3)	33261013	396	170	348	124	121	80	39	99	57	0	0.0997	1.000	1.000
287	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACADVL(6), ACAT1(7), ACAT2(9), ACOX1(11), ACOX3(10), ACSL1(9), ACSL3(12), ACSL4(10), ACSL5(10), ACSL6(10), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CPT1A(13), CPT1B(14), CPT1C(10), CPT2(3), CYP4A11(8), CYP4A22(13), DCI(4), ECHS1(4), EHHADH(15), GCDH(8), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), PECI(2)	33630441	389	170	355	118	103	74	63	98	51	0	0.0180	1.000	1.000
288	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(27), CALM2(1), CALM3(1), CREB1(3), ELK1(4), FOS(5), GNAI1(5), GNAQ(11), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), JUN(2), MAP2K1(12), MAPK3(4), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), RAF1(16), RPS6KA3(16), SYT1(14)	22182296	292	169	249	97	116	69	24	47	36	0	0.109	1.000	1.000
289	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(13), ACTN2(19), ACTN3(6), BCAR1(6), CSK(5), CTNNA1(28), CTNNA2(38), CTNNB1(120), PECAM1(4), PTK2(24), PXN(2), SRC(3), VCL(10)	12341276	278	168	222	107	63	81	35	69	29	1	0.686	1.000	1.000
290	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(14), CAPN1(2), CAPN2(10), CAPNS1(4), CAPNS2(4), CXCR3(5), EGF(8), EGFR(115), HRAS(4), ITGA1(12), ITGB1(13), MAPK1(3), MAPK3(4), MYL2(2), MYLK(33), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTK2(24), PXN(2), TLN1(23)	22698575	317	168	293	131	75	94	50	64	33	1	0.715	1.000	1.000
291	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(27), BAD(1), BAX(16), BCL2(2), BCL2A1(5), BCL2L1(1), BCL2L2(2), BOK(2), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CD40(7), CD40LG(10), CRADD(4), CYCS(1), DAXX(18), DFFA(6), DFFB(2), FADD(1), FAS(9), FASLG(3), IKBKE(9), LTA(1), NFKB1(11), NFKBIA(1), NGFR(5), NR3C1(11), NTRK1(17), PTPN13(23), RIPK1(7), SFRS2IP(3), TFG(8), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12), TRAF6(4)	28956784	319	165	281	147	66	78	31	69	74	1	1.000	1.000	1.000
292	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(6), GTF2A1L(13), GTF2A2(1), GTF2B(12), GTF2E1(13), GTF2E2(1), GTF2F1(7), GTF2F2(1), GTF2H1(6), GTF2H3(4), GTF2H4(3), GTF2I(2), GTF2IRD1(19), TAF1(32), TAF10(1), TAF12(4), TAF13(3), TAF1L(66), TAF2(20), TAF4(11), TAF4B(11), TAF5(13), TAF5L(3), TAF6(9), TAF6L(5), TAF7(3), TAF7L(14), TAF9(3), TAF9B(1), TBPL1(3), TBPL2(2)	25193065	292	164	259	87	79	52	32	80	48	1	0.168	1.000	1.000
293	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IL6(7), IL6R(8), IL6ST(15), JAK1(22), JAK2(55), JAK3(31), JUN(2), MAP2K1(12), MAPK3(4), PTPN11(41), RAF1(16), SHC1(14), SOS1(16), SRF(4), STAT3(10)	16194606	288	164	219	89	63	101	34	50	35	5	0.132	1.000	1.000
294	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ABP1(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH3A1(7), ALDH3B1(15), ALDH3B2(8), AOC2(12), AOC3(10), AOX1(15), DBH(9), DCT(22), DDC(5), FAH(4), GOT1(7), GOT2(2), GSTZ1(5), HGD(6), HPD(7), MAOA(7), MAOB(9), PNMT(3), TAT(16), TPO(36), TYR(12)	21138863	287	164	246	100	89	53	33	71	41	0	0.297	1.000	1.000
295	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(18), CCNB1(8), CCND1(2), CCND2(3), CCND3(2), CCNE1(6), CCNH(7), CDC25A(11), CDK2(5), CDK4(4), CDK6(3), CDK7(3), CDKN1A(2), CDKN1B(6), CDKN2A(9), CDKN2C(3), CDKN2D(1), RB1(139), RBL1(21), TFDP1(10)	10864390	263	163	207	100	47	86	20	61	41	8	0.548	1.000	1.000
296	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(4), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B1(15), ALDH3B2(8), ALDH7A1(8), ALDH9A1(4), AMDHD1(7), AOC2(12), AOC3(10), ASPA(8), CARM1(3), CNDP1(7), DDC(5), FTCD(5), HAL(12), HARS(6), HARS2(8), HDC(14), HEMK1(1), HNMT(11), LCMT1(1), LCMT2(6), MAOA(7), MAOB(9), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), PRPS1(9), PRPS2(6), UROC1(10), WBSCR22(2)	26443524	315	163	286	92	89	62	42	76	46	0	0.0348	1.000	1.000
297	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(11), AKT2(8), AKT3(8), ARHGEF11(24), BCL2(2), CDC42(3), DLG4(10), GNA13(3), IKBKG(2), LPA(30), MAP2K4(36), MAP3K1(21), MAP3K5(16), MAPK8(17), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PI3(3), PIK3CB(6), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RDX(16), ROCK1(35), ROCK2(20), SERPINA4(10), SRF(4)	32842094	399	163	368	121	114	60	41	109	69	6	0.280	1.000	1.000
298	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B1(15), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), ESCO1(22), ESCO2(18), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), PRDX6(5), SH3GLB1(6), TAT(16), TPO(36)	23395147	332	162	283	103	112	54	37	71	57	1	0.143	1.000	1.000
299	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(6), ABO(7), B3GALNT1(6), B3GALT1(3), B3GALT2(10), B3GALT4(4), B3GALT5(5), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALNT1(13), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), B4GALT6(10), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GBGT1(1), GCNT2(26), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGX(4), PIGZ(6), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4), ST3GAL5(2), ST3GAL6(16), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10), UGCG(9)	31239428	378	162	340	123	116	65	28	97	71	1	0.519	1.000	1.000
300	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	33	AKT1(11), ATF1(6), CDC42(3), CREB1(3), CREB3(6), CREB5(8), DUSP1(7), DUSP10(6), EEF2K(11), ELK1(4), IL1R1(7), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAP3K10(11), MAP3K4(53), MAP3K5(16), MAP3K7(9), MAPK1(3), MAPK12(4), MAPK13(6), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MKNK1(4), MKNK2(7), MYEF2(14), NFKB1(11), NR2C2(11), SRF(4), TRAF6(4)	22400374	301	162	266	82	75	52	48	70	54	2	0.0249	1.000	1.000
301	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(27), CD3D(5), CD3E(2), CD3G(16), CD4(4), CREBBP(81), CSK(5), GNAS(39), GNB1(3), GNGT1(1), HLA-DRA(12), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12)	14922482	294	161	244	90	92	74	26	48	51	3	0.105	1.000	1.000
302	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), AGMAT(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH4A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), GAMT(6), GATM(2), GLUD1(4), GOT1(7), GOT2(2), MAOA(7), MAOB(9), NOS1(31), NOS3(23), OAT(4), ODC1(8), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(6), RARS(9), SMS(4)	29618054	368	161	332	117	124	60	47	81	56	0	0.131	1.000	1.000
303	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(27), CD3D(5), CD3E(2), CD3G(16), CD4(4), CREBBP(81), CSK(5), GNAS(39), GNB1(3), GNGT1(1), HLA-DRA(12), HLA-DRB1(7), LCK(9), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PTPRC(36), ZAP70(12)	14922482	294	161	244	90	92	74	26	48	51	3	0.105	1.000	1.000
304	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(8), ACAA1(7), ACAA2(4), ACADM(12), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), AOX1(15), AUH(3), BCAT1(5), BCAT2(1), BCKDHA(9), BCKDHB(3), DBT(10), DLD(4), ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HADHB(10), HIBADH(2), HIBCH(3), HMGCL(1), HMGCS1(1), HMGCS2(6), HSD17B10(3), HSD17B4(9), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), OXCT2(3), PCCA(17), PCCB(6)	30325901	324	161	293	82	96	58	41	67	61	1	0.00470	1.000	1.000
305	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(17), AGT(12), AGTR2(17), EDN1(3), EDNRA(9), EDNRB(19), EGF(8), EGFR(115), FOS(5), HRAS(4), JUN(2), MYC(5), NFKB1(11), PLCG1(19), PRKCA(8), RELA(10)	14190326	264	160	230	108	63	75	41	54	31	0	0.777	1.000	1.000
306	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(9), ASPH(15), COPS5(2), CREB1(3), EDN1(3), EP300(56), EPO(1), HIF1A(16), JUN(2), LDHA(14), NOS3(23), P4HB(6), VHL(105)	11126917	255	160	190	88	41	96	35	43	40	0	0.259	1.000	1.000
307	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(8), ACACA(36), ACACB(40), ACADM(12), ACAT1(7), ACAT2(9), ACSS1(7), ACSS2(10), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH7A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), HIBCH(3), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SUCLA2(9), SUCLG1(3), SUCLG2(1)	28010401	337	159	304	71	99	53	50	76	59	0	9.17e-05	1.000	1.000
308	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(12), ADRA1B(6), ADRA1D(4), ADRA2A(5), ADRB1(4), ADRB2(3), ADRB3(7), CHRM1(4), CHRM2(29), CHRM3(23), CHRM4(1), CHRM5(6), DRD1(9), DRD2(9), DRD3(6), DRD5(14), HRH1(4), HRH2(16), HTR1A(17), HTR1B(13), HTR1D(4), HTR1E(18), HTR1F(9), HTR2A(24), HTR2B(7), HTR2C(15), HTR4(7), HTR5A(23), HTR6(3), HTR7(13)	16283720	315	158	277	110	128	61	38	54	33	1	0.0567	1.000	1.000
309	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(3), CAD(23), CANT1(5), CDA(4), CTPS(6), CTPS2(5), DCK(4), DCTD(4), DHODH(11), DPYD(42), DPYS(12), DTYMK(1), ENTPD1(5), ITPA(6), NME1(1), NT5C(1), NT5E(7), NT5M(3), POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14), RRM1(3), RRM2(5), TK1(2), TK2(3), TXNRD1(9), TYMS(6), UCK1(1), UCK2(3), UMPS(4), UNG(3), UPB1(9), UPP1(5)	38761888	391	158	374	123	108	63	58	110	52	0	0.131	1.000	1.000
310	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(12), AKR1D1(9), ARSD(9), ARSE(4), CARM1(3), CYP11B1(17), CYP11B2(7), CYP19A1(11), HEMK1(1), HSD11B1(2), HSD11B2(1), HSD17B1(2), HSD17B12(3), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), SULT2B1(4), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), WBSCR22(2)	33084863	348	157	329	106	90	64	41	88	65	0	0.0935	1.000	1.000
311	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(7), CDC42(3), CREB1(3), DAXX(18), DDIT3(5), ELK1(4), GRB2(11), HRAS(4), HSPB2(3), MAP2K4(36), MAP2K6(5), MAP3K1(21), MAP3K5(16), MAP3K7(9), MAP3K9(11), MAPK14(8), MAPKAPK2(5), MAPKAPK5(7), MAX(5), MEF2A(7), MEF2C(15), MEF2D(3), MKNK1(4), MYC(5), PLA2G4A(16), RAC1(2), RIPK1(7), RPS6KA5(13), SHC1(14), STAT1(17), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TRAF2(8)	24760894	326	157	293	97	91	72	36	74	51	2	0.118	1.000	1.000
312	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(6), CHUK(27), ELK1(4), FOS(5), IKBKB(9), IKBKG(2), IRAK1(6), JUN(2), LY96(4), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), PPARA(7), RELA(10), TIRAP(5), TLR10(14), TLR2(12), TLR3(15), TLR4(18), TLR6(14), TLR7(18), TLR9(16), TOLLIP(5), TRAF6(4)	24663813	332	156	313	88	82	63	35	96	53	3	0.0246	1.000	1.000
313	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(30), EEF1A2(8), EEF1B2(3), EEF1D(12), EEF1G(1), EEF2(7), EEF2K(11), EIF1AX(1), EIF2AK1(16), EIF2AK2(5), EIF2AK3(14), EIF2B1(4), EIF2B2(4), EIF2B3(10), EIF2B4(2), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF4A2(12), EIF4EBP2(4), EIF4G1(19), EIF4G3(19), EIF5(6), EIF5A(3), EIF5B(20), ETF1(13), GSPT2(6), KIAA0664(19), PABPC1(8), PABPC3(23), PAIP1(7), SLC35A4(3)	29310599	313	156	268	82	71	72	29	70	71	0	0.0443	1.000	1.000
314	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(2), BTK(12), CALM2(1), CALM3(1), CD79A(6), CD79B(3), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK14(8), MAPK3(4), MAPK8(17), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SYK(8), SYT1(14), VAV1(24)	25300891	309	155	275	95	95	70	34	63	46	1	0.107	1.000	1.000
315	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(8), ADC(3), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EARS2(3), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GFPT2(12), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), GMPS(16), GNPNAT1(1), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSR(5), GSS(9), NADSYN1(4), NAGK(7), PPAT(8), QARS(14)	27172490	303	155	281	83	85	59	37	85	37	0	0.0280	1.000	1.000
316	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(36), ACACB(40), ACAT1(7), ACAT2(9), ACOT12(11), ACSS1(7), ACSS2(10), ACYP1(2), AKR1B1(6), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHA(14), LDHAL6A(6), LDHAL6B(7), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PCK2(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4)	32074289	374	155	342	118	112	64	50	89	59	0	0.157	1.000	1.000
317	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(6), ADCY3(11), ADCY9(22), AK1(2), ARF1(1), ARF4(5), ARF5(2), ARF6(1), ARL4D(3), ATP6V0A1(7), ATP6V0A2(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V0D2(12), ATP6V1A(13), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ERO1L(4), GNAS(39), PDIA4(9), PLCG1(19), PLCG2(28), PRKCA(8), SEC61A1(10), SEC61A2(4), SEC61B(4), SEC61G(4), TRIM23(18)	25093398	309	155	257	104	116	68	31	55	39	0	0.199	1.000	1.000
318	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(5), ALG10(9), ALG10B(13), ALG11(10), ALG12(7), ALG13(14), ALG14(3), ALG2(8), ALG3(2), ALG5(5), ALG6(5), ALG8(13), ALG9(8), B4GALT1(8), B4GALT2(7), B4GALT3(8), DAD1(3), DDOST(4), DHDDS(6), DPAGT1(14), DPM1(3), FUT8(11), GANAB(13), MAN1A1(14), MAN1A2(5), MAN1B1(7), MAN1C1(11), MAN2A1(22), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), MGAT5B(10), RFT1(3), RPN1(4), RPN2(7), ST6GAL1(3), STT3B(11)	27880274	325	154	293	112	84	57	34	88	62	0	0.819	1.000	1.000
319	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(7), ACAA2(4), ACADL(6), ACADM(12), ACADS(4), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), AOX1(15), BCAT1(5), BCKDHA(9), BCKDHB(3), ECHS1(4), EHHADH(15), HADHA(12), HADHB(10), HIBADH(2), HMGCL(1), IVD(6), MCCC1(19), MCCC2(6), MCEE(9), MUT(8), OXCT1(3), PCCA(17), PCCB(6), SDS(3)	25203908	308	153	277	72	88	55	41	71	52	1	0.000551	1.000	1.000
320	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(9), BRAF(125), CAMP(1), CREB1(3), CREB3(6), CREB5(8), MAPK1(3), RAF1(16), SNX13(37), SRC(3), TERF2IP(4)	7846476	219	152	125	64	21	59	19	100	20	0	0.220	1.000	1.000
321	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(8), ABP1(4), ACADL(6), ACADM(12), ACADSB(7), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), MLYCD(4), SDS(3), SMS(4), UPB1(9)	20034021	296	150	271	79	87	47	45	80	37	0	0.00356	1.000	1.000
322	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(10), CDC7(25), CDK2(5), DIAPH2(28), GMNN(5), MCM10(12), MCM2(4), MCM3(5), MCM4(14), MCM5(9), MCM6(9), MCM7(14), NACA(25), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(5), POLA2(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), PRIM1(5), RFC1(25), RFC2(3), RFC4(8), RFC5(8), RPA1(12), RPA2(1), RPA3(4), RPA4(6), UBA52(3), UBB(3), UBC(7)	33914887	349	148	301	107	68	62	47	93	78	1	0.369	1.000	1.000
323	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(8), AGXT2(9), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), ATP6V0C(1), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CPT1B(14), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), MAOA(7), MAOB(9), PEMT(2), PISD(8), PLCB2(11), PLCG1(19), PLCG2(28), PSPH(2), SARDH(17), SARS(6), SHMT1(7), SHMT2(5), TARS(10)	28265420	315	148	287	118	118	46	39	63	49	0	0.661	1.000	1.000
324	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(4), ALOX12B(6), ALOX15(5), ALOX15B(11), ALOX5(12), CBR1(2), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP2U1(5), CYP4A11(8), CYP4A22(13), CYP4F2(12), CYP4F3(11), DHRS4(1), EPHX2(5), GGT1(11), GPX1(5), GPX2(3), GPX3(4), GPX4(1), GPX5(7), GPX6(10), GPX7(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PTGDS(2), PTGES(1), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	26624421	287	148	263	97	92	39	36	74	45	1	0.452	1.000	1.000
325	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(11), CFL1(2), GNAQ(11), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), LIMK1(8), MAP2K1(12), MAPK1(3), MAPK3(4), MYL2(2), NOX1(4), PIK3C2G(21), PLCB1(23), PPP1R12B(33), PRKCA(8), PTK2(24), RAF1(16), ROCK2(20)	16889460	251	147	201	73	79	50	20	51	50	1	0.202	1.000	1.000
326	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(35), ATP4B(3), ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), ATP7A(13), ATP7B(16), COX10(6), COX4I1(5), COX5A(1), COX5B(2), COX6A2(2), COX6B1(1), COX6C(3), COX7A1(1), COX7A2(2), COX8A(2), NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3), PPA2(5), SDHA(14), SDHB(3), SHMT1(7), UQCRB(2), UQCRC1(4), UQCRFS1(3), UQCRH(1)	26969228	296	147	267	93	90	52	38	62	54	0	0.127	1.000	1.000
327	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM2(1), CALM3(1), CRKL(5), GNAQ(11), GRB2(11), HRAS(4), JUN(2), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K4(36), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), MAPK8(17), PAK1(11), PLCG1(19), PRKCA(8), PTK2B(13), RAC1(2), RAF1(16), SHC1(14), SOS1(16), SRC(3), SYT1(14)	19122631	272	147	236	89	62	62	33	75	38	2	0.394	1.000	1.000
328	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(7), BCR(12), BLNK(2), ELK1(4), FOS(5), GRB2(11), HRAS(4), JUN(2), LYN(13), MAP2K1(12), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8IP3(12), PAPPA(39), RAC1(2), RPS6KA1(9), RPS6KA3(16), SHC1(14), SOS1(16), SYK(8), VAV1(24), VAV2(20), VAV3(30)	20917090	290	146	258	71	83	61	36	75	34	1	0.00205	1.000	1.000
329	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(5), AKT1(11), AKT2(8), AKT3(8), DAG1(10), GNAQ(11), IKBKG(2), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), PDK1(7), PHKA2(19), PIK3CB(6), PITX2(2), PLD1(19), PLD2(10), PLD3(7), VN1R1(7)	28429292	314	146	306	103	103	60	39	70	41	1	0.187	1.000	1.000
330	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), ELK1(4), FPR1(8), GNA15(6), GNB1(3), GNGT1(1), HRAS(4), MAP2K1(12), MAP2K2(3), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAPK1(3), MAPK14(8), MAPK3(4), NCF1(4), NCF2(10), NFATC2(12), NFATC3(15), NFATC4(12), NFKB1(11), NFKBIA(1), PAK1(11), PIK3C2G(21), PLCB1(23), PPP3CA(5), PPP3CB(11), PPP3CC(7), RAC1(2), RAF1(16), RELA(10), SYT1(14)	25078048	296	145	273	104	100	51	33	70	41	1	0.385	1.000	1.000
331	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(8), ACACA(36), ACADL(6), ACADM(12), ACADSB(7), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH6A1(6), ALDH9A1(4), ECHS1(4), EHHADH(15), HADHA(12), LDHA(14), LDHB(8), LDHC(4), MCEE(9), MLYCD(4), MUT(8), PCCA(17), PCCB(6), SDS(3), SUCLA2(9), SUCLG1(3), SUCLG2(1)	23384916	301	145	268	64	87	52	43	67	52	0	0.000235	1.000	1.000
332	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(36), ACAT1(7), ACAT2(9), ACYP1(2), ADH5(7), AKR1B1(6), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), DLAT(10), DLD(4), GRHPR(2), HAGH(1), LDHA(14), LDHB(8), LDHC(4), LDHD(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PKLR(12), PKM2(4)	25038141	315	144	282	104	92	62	40	75	46	0	0.253	1.000	1.000
333	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(8), F12(5), F13B(12), F2(10), F5(37), F7(7), F8(50), F9(20), FGA(23), FGB(6), FGG(7), LPA(30), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10), SERPINF2(4), VWF(36)	24266775	325	143	295	129	81	61	48	83	49	3	0.823	1.000	1.000
334	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(10), AARS2(13), CARS(11), CARS2(6), DARS(5), DARS2(8), EARS2(3), EPRS(27), FARS2(7), FARSA(6), FARSB(12), GARS(8), HARS(6), HARS2(8), IARS(10), IARS2(19), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), MTFMT(1), NARS(5), NARS2(11), PARS2(2), QARS(14), RARS(9), RARS2(10), SARS(6), SARS2(4), TARS(10), TARS2(10), VARS(7), VARS2(9), WARS(4), WARS2(7), YARS(4), YARS2(7)	36535307	328	143	319	84	103	43	44	88	50	0	0.0279	1.000	1.000
335	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(8), AGXT2(9), AKR1B10(3), ALAS1(12), ALAS2(12), AMT(2), AOC2(12), AOC3(10), BHMT(10), CBS(4), CHDH(6), CHKA(6), CHKB(3), CTH(6), DAO(11), DLD(4), DMGDH(15), GAMT(6), GARS(8), GATM(2), GCAT(4), GLDC(15), GNMT(3), HSD3B7(3), MAOA(7), MAOB(9), PEMT(2), PHGDH(3), PIPOX(9), PISD(8), PSAT1(7), PSPH(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SARDH(17), SARS(6), SARS2(4), SDS(3), SHMT1(7), SHMT2(5), TARS(10), TARS2(10)	29237069	303	142	286	109	110	39	39	72	43	0	0.511	1.000	1.000
336	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(15), POLA2(6), POLB(6), POLD1(20), POLD2(2), POLD3(15), POLE(41), POLE2(6), POLE3(1), POLG(9), POLG2(4), POLH(16), POLI(29), POLK(11), POLL(2), POLM(12), POLQ(42), PRIM1(5), PRIM2(3), REV1(16), REV3L(45), RFC5(8)	28628946	314	142	279	88	67	51	38	84	72	2	0.302	1.000	1.000
337	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(28), GABBR1(20), GPRC5A(5), GPRC5B(4), GPRC5C(10), GPRC5D(3), GRM1(37), GRM2(16), GRM3(21), GRM4(15), GRM5(33), GRM7(36), GRM8(29)	13402320	257	141	223	103	104	34	32	53	34	0	0.630	1.000	1.000
338	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(8), ABP1(4), ACADM(12), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AOC2(12), AOC3(10), CNDP1(7), DPYD(42), DPYS(12), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HIBCH(3), MLYCD(4), SMS(4), SRM(1), UPB1(9)	18476994	263	141	239	77	76	42	41	70	34	0	0.0364	1.000	1.000
339	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(5), C1GALT1(2), C1GALT1C1(4), GALNT1(4), GALNT10(8), GALNT11(7), GALNT12(5), GALNT13(20), GALNT14(14), GALNT2(15), GALNT3(15), GALNT5(21), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GALNTL1(11), GALNTL2(13), GALNTL4(5), GALNTL5(17), GCNT1(9), GCNT3(6), GCNT4(14), OGT(10), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(6), WBSCR17(39)	22435471	288	141	274	102	100	42	36	72	38	0	0.596	1.000	1.000
340	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(25), AASDHPPT(3), AASS(14), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), ATP6V0C(1), BBOX1(5), DLST(4), DOT1L(10), ECHS1(4), EHHADH(15), EHMT1(11), EHMT2(10), GCDH(8), HADHA(12), PLOD1(8), PLOD2(10), PLOD3(7), SDS(3), SHMT1(7), SHMT2(5), TMLHE(6)	23744664	279	141	251	71	81	53	38	64	43	0	0.00219	1.000	1.000
341	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(8), EGFR(115), MAP2K1(12), MAP3K1(21), MAPK14(8), NCOR2(44), RARA(6), RXRA(8), THRA(6), THRB(14)	11147728	242	140	207	92	57	70	36	46	33	0	0.688	1.000	1.000
342	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(3), B4GALT1(8), B4GALT2(7), G6PC(5), G6PC2(3), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANC(9), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), HSD3B7(3), LALBA(2), LCT(46), MGAM(26), PFKL(7), PFKM(5), PFKP(16), PGM1(10), PGM3(7), RDH11(4), RDH12(7), RDH13(4), RDH14(1), UGP2(12)	24841549	283	139	272	100	103	43	31	77	29	0	0.324	1.000	1.000
343	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(7), ACAA2(4), ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), AKR1B10(3), AKR1C4(12), AKR1D1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), HSD3B7(3), LIPA(3), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SLC27A5(9), SOAT1(6), SOAT2(4), SRD5A1(2), SRD5A2(2)	21633822	261	139	235	74	66	55	38	70	31	1	0.0322	1.000	1.000
344	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH3B1(15), ALDH3B2(8), ALDH9A1(4), AOC2(12), AOC3(10), ASPA(8), CNDP1(7), DDC(5), HAL(12), HARS(6), HDC(14), HNMT(11), MAOA(7), MAOB(9), PRPS1(9), PRPS2(6)	16887995	236	138	205	55	68	47	31	58	32	0	0.00141	1.000	1.000
345	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(7), ABP1(4), AOC2(12), AOC3(10), CES1(14), CES7(1), DDHD1(51), ESCO1(22), ESCO2(18), LIPA(3), MYST3(34), MYST4(33), NAT6(2), PLA1A(10), PNPLA3(6), PPME1(2), PRDX6(5), SH3GLB1(6)	17463384	240	137	177	73	52	35	24	50	78	1	0.683	1.000	1.000
346	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(8), B4GALT2(7), FBP2(5), G6PC(5), GAA(14), GALE(4), GALK1(2), GALK2(5), GALT(3), GANAB(13), GCK(6), GLA(7), GLB1(9), HK1(13), HK2(7), HK3(22), LALBA(2), LCT(46), MGAM(26), PFKM(5), PFKP(16), PGM1(10), PGM3(7)	21134447	248	136	239	93	90	44	27	61	26	0	0.538	1.000	1.000
347	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), CYP2C19(12), CYP2C9(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), HADHA(12), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3)	21011582	281	136	247	82	71	62	37	68	42	1	0.0906	1.000	1.000
348	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(25), C5(25), C6(27), C7(11), ICAM1(4), IL1A(1), IL6(7), IL8(6), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), SELP(15), SELPLG(19), TNF(2), VCAM1(15)	16907866	229	136	210	75	74	30	21	50	52	2	0.300	1.000	1.000
349	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(3), CREBBP(81), EP300(56), NCOA3(21), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RARA(6), RXRA(8)	14144361	213	135	187	87	52	56	28	41	36	0	0.754	1.000	1.000
350	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(10), AARS2(13), ABAT(8), ACY3(4), ADSL(13), ADSS(8), ADSSL1(6), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), ASRGL1(1), ASS1(5), CAD(23), CRAT(11), DARS(5), DARS2(8), DDO(6), DLAT(10), DLD(4), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), NARS2(11), PC(16), PDHA1(8), PDHA2(17), PDHB(3)	25476532	280	135	263	109	96	39	41	64	40	0	0.747	1.000	1.000
351	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(12), ALAS2(12), BLVRA(2), BLVRB(2), COX10(6), COX15(8), CP(24), CPOX(4), EARS2(3), EPRS(27), FECH(4), FTH1(1), FTMT(8), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), MMAB(2), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), UROD(3), UROS(5)	28229195	298	135	269	72	67	55	39	80	57	0	0.0271	1.000	1.000
352	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(27), CREBBP(81), EP300(56), FADD(1), HDAC3(3), IKBKB(9), IKBKG(2), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	15327977	219	135	188	81	59	66	23	36	35	0	0.463	1.000	1.000
353	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(8), ARG1(2), ARG2(6), ASL(5), ASS1(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), DAO(11), EPRS(27), GAMT(6), GATM(2), GLUD1(4), GLUD2(22), GOT1(7), GOT2(2), LAP3(4), NOS1(31), NOS3(23), OAT(4), OTC(17), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(2), PRODH(5), RARS(9), RARS2(10)	23926762	279	134	257	86	89	38	41	69	42	0	0.175	1.000	1.000
354	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(20), ALDH3A1(7), ALDH3B1(15), ALDH3B2(8), AOC2(12), AOC3(10), DDC(5), EPX(14), GOT1(7), GOT2(2), HPD(7), LPO(10), MAOA(7), MAOB(9), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), TAT(16), TPO(36)	14847713	218	134	185	62	86	29	25	40	38	0	0.0430	1.000	1.000
355	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(10), BIRC2(7), BIRC3(18), CASP3(4), CASP8(20), CFLAR(3), FADD(1), IKBKG(2), JUN(2), MAP2K4(36), MAP3K3(8), MAP3K7(9), NFKB1(11), NFKB2(6), NFKBIA(1), NFKBIB(5), NFKBIE(5), NR2C2(11), RALBP1(8), RIPK1(7), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF2(8)	17303928	231	134	199	70	49	60	24	50	47	1	0.181	1.000	1.000
356	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CYP19A1(11), CYP1A1(10), CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), CYP2B6(4), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2D6(9), CYP2E1(11), CYP2F1(7), CYP2J2(3), CYP3A4(9), CYP3A5(3), CYP3A7(11), CYP4B1(12), CYP4F8(5), CYP51A1(3), PON1(12)	19550871	255	133	246	77	98	42	22	63	28	2	0.0872	1.000	1.000
357	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(16), ALDOC(3), DLAT(10), DLD(4), ENO1(3), ENO2(3), ENO3(6), FBP1(1), FBP2(5), G6PC(5), GAPDH(2), GAPDHS(3), GCK(6), GOT1(7), GOT2(2), GPI(6), HK1(13), HK2(7), HK3(22), LDHA(14), LDHAL6B(7), LDHB(8), LDHC(4), MDH1(8), MDH2(3), PC(16), PCK1(6), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PFKL(7), PFKM(5), PFKP(16), PGAM1(4), PGAM2(4), PGK1(3), PGK2(10), PKLR(12), PKM2(4), TNFAIP1(4), TPI1(3)	28154287	295	133	268	122	113	49	27	67	39	0	0.849	1.000	1.000
358	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ACY1(6), ADC(3), AGMAT(7), ALDH18A1(8), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4), AMD1(4), AOC2(12), AOC3(10), ARG1(2), ARG2(6), ASL(5), ASS1(5), CPS1(39), GATM(2), MAOA(7), MAOB(9), NAGS(6), ODC1(8), OTC(17), SAT1(5), SAT2(2), SMS(4), SRM(1)	20265396	244	133	217	71	73	50	31	59	31	0	0.0570	1.000	1.000
359	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(7), ELK1(4), EPO(1), EPOR(2), FOS(5), GRB2(11), HRAS(4), JAK2(55), JUN(2), MAP2K1(12), MAPK3(4), MAPK8(17), PLCG1(19), PTPN6(4), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20)	14736094	223	132	182	75	54	70	21	40	34	4	0.597	1.000	1.000
360	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(8), EGFR(115), ERBB3(32), NRG1(33), UBE2D1(1)	7284913	189	132	159	67	43	69	26	35	16	0	0.334	1.000	1.000
361	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(12), ACO1(12), ACO2(7), CLYBL(7), CS(2), DLD(4), DLST(4), FH(10), IDH1(21), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), OGDHL(16), PC(16), PCK1(6), PCK2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1)	20525842	208	132	193	71	65	34	30	53	26	0	0.303	1.000	1.000
362	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(5), CDKN1B(6), CKS1B(2), CUL1(17), NEDD8(1), RB1(139), RBX1(1), SKP2(3), TFDP1(10), UBE2M(2)	6024134	192	132	139	73	31	70	10	38	35	8	0.660	1.000	1.000
363	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(18), CCNE1(6), CDC34(2), CDK2(5), CUL1(17), RB1(139), SKP2(3), TFDP1(10)	6148005	200	132	145	78	34	73	10	44	31	8	0.619	1.000	1.000
364	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(27), BCL2(2), BID(2), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CFLAR(3), CHUK(27), CYCS(1), DFFA(6), DFFB(2), FADD(1), GAS2(4), LMNA(1), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), SPTAN1(30), TNFRSF10A(8), TNFRSF10B(8), TNFRSF25(2), TNFSF10(3), TNFSF12(2), TRAF2(8)	22591935	240	131	209	79	57	52	27	54	49	1	0.485	1.000	1.000
365	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), CALM3(1), DLG4(10), GRIN1(5), GRIN2A(55), GRIN2B(35), GRIN2C(11), GRIN2D(9), NOS1(31), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8), SYT1(14)	16989570	238	131	222	100	85	43	22	51	36	1	0.781	1.000	1.000
366	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(8), ACADS(4), ACAT1(7), ACAT2(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH5A1(8), ALDH9A1(4), ECHS1(4), EHHADH(15), GAD1(17), GAD2(15), HADHA(12), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(8), PDHA2(17), PDHB(3), SDHB(3), SDS(3)	17956584	242	130	215	68	72	46	34	60	30	0	0.0170	1.000	1.000
367	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(7), ELK1(4), FOS(5), GRB2(11), HRAS(4), IL2(5), IL2RA(6), IL2RB(5), IL2RG(9), JAK1(22), JAK3(31), JUN(2), LCK(9), MAP2K1(12), MAPK3(4), MAPK8(17), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20), SYK(8)	15861493	237	130	195	59	59	56	24	46	50	2	0.0472	1.000	1.000
368	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(4), ALOX15(5), ALOX5(12), CBR1(2), CYP4F2(12), CYP4F3(11), EPX(14), GGT1(11), LPO(10), LTA4H(2), MPO(17), PLA2G1B(1), PLA2G2E(2), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13), TPO(36)	18683209	227	130	207	73	93	28	27	42	37	0	0.168	1.000	1.000
369	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(7), ACAA2(4), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH6(9), ADH7(7), ADHFE1(9), AKR1C4(12), AKR1D1(9), ALDH1A1(12), ALDH1A2(17), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH9A1(4), BAAT(3), CEL(13), CYP27A1(4), CYP7A1(14), HADHB(10), SOAT2(4), SRD5A1(2), SRD5A2(2)	15991332	223	129	198	52	54	51	31	59	27	1	0.00182	1.000	1.000
370	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(8), ALDH4A1(8), ALDH5A1(8), CAD(23), CPS1(39), EPRS(27), GAD1(17), GAD2(15), GCLC(8), GCLM(3), GFPT1(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), GMPS(16), GOT1(7), GOT2(2), GPT(7), GPT2(4), GSS(9), NADSYN1(4), PPAT(8), QARS(14)	22869210	250	129	228	64	65	53	31	70	31	0	0.0209	1.000	1.000
371	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(14), ADCY1(27), CAP1(5), CCNB1(8), CDC25C(6), GNAI1(5), GNAS(39), GNB1(3), GNGT1(1), HRAS(4), MAPK1(3), MAPK3(4), MYT1(25), PIN1(2), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RPS6KA1(9), SRC(3)	13313794	193	129	170	56	84	37	21	36	15	0	0.0166	1.000	1.000
372	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(11), CD3D(5), CD3E(2), CD3G(16), CXCR3(5), ETV5(15), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), JAK2(55), JUN(2), MAP2K6(5), MAPK14(8), MAPK8(17), STAT4(13), TYK2(5)	12940896	209	127	172	78	32	69	26	47	32	3	0.785	1.000	1.000
373	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(51), ARHGEF1(15), GNA12(7), GNA13(3), GNAQ(11), GNB1(3), GNGT1(1), MYL2(2), MYLK(33), PLCB1(23), PPP1R12B(33), PRKCA(8), ROCK1(35)	14524526	225	126	165	59	45	53	18	42	63	4	0.182	1.000	1.000
374	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM2(1), CALM3(1), CHUK(27), EGR2(16), EGR3(6), GNAQ(11), MAP3K1(21), MYC(5), NFATC2(12), NFKB1(11), NFKBIA(1), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RELA(10), SYT1(14), VIP(3), VIPR2(11)	17855655	227	126	205	73	70	50	24	44	39	0	0.182	1.000	1.000
375	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(15), AGT(12), AGTR1(14), AGTR2(17), CMA1(1), COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), REN(10)	18109524	216	125	205	72	54	30	29	60	43	0	0.100	1.000	1.000
376	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(12), CALCRL(9), CD97(12), CRHR1(6), CRHR2(6), ELTD1(14), EMR1(17), EMR2(11), GHRHR(2), GIPR(1), GLP1R(11), GLP2R(10), GPR64(19), LPHN1(20), LPHN2(30), LPHN3(30), SCTR(6), VIPR1(7), VIPR2(11)	18379554	239	125	235	99	79	37	20	74	29	0	0.764	1.000	1.000
377	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(3), ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), FUK(9), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), HSD3B7(3), KHK(4), LHPP(6), MPI(4), MTMR1(13), MTMR2(8), MTMR6(11), PFKFB1(14), PFKFB2(5), PFKFB3(3), PFKFB4(5), PFKL(7), PFKM(5), PFKP(16), PGM2(4), PHPT1(2), PMM1(5), PMM2(2), RDH11(4), RDH12(7), RDH13(4), RDH14(1), SORD(2), TPI1(3), TSTA3(1)	25000486	252	125	234	95	97	36	26	61	32	0	0.575	1.000	1.000
378	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(81), EP300(56), LPL(12), NCOA1(15), NCOA2(23), PPARG(4), RXRA(8)	12259823	199	125	178	83	50	56	28	37	28	0	0.735	1.000	1.000
379	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(5), NFYB(2), NFYC(10), RB1(139), SP1(7), SP3(13)	4757427	176	125	123	59	23	74	10	37	24	8	0.121	1.000	1.000
380	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(26), COL4A2(18), COL4A3(14), COL4A4(27), COL4A5(36), COL4A6(26), P4HB(6), SLC23A1(10), SLC23A2(18), SLC2A1(7), SLC2A3(13)	17893323	201	125	188	77	52	26	31	51	41	0	0.268	1.000	1.000
381	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(6), CASP2(8), CHUK(27), CRADD(4), IKBKB(9), IKBKG(2), JUN(2), LTA(1), MAP2K3(11), MAP2K4(36), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP4K2(6), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNF(2), TNFRSF1A(4), TRAF2(8)	16035820	220	124	198	72	59	49	27	52	32	1	0.238	1.000	1.000
382	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(19), EGF(8), EGFR(115), HGS(10), RAB5A(4), TF(21), TFRC(7)	8917235	184	123	158	72	35	67	25	37	19	1	0.409	1.000	1.000
383	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), DAG1(10), ITPKA(3), ITPKB(15), ITPR1(43), ITPR2(49), ITPR3(44), NFAT5(6), PDE6A(14), PDE6B(11), PDE6C(12), PDE6D(2), SLC6A13(10), TF(21)	23328549	267	123	265	89	83	48	29	61	45	1	0.193	1.000	1.000
384	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(7), ACAT2(9), ACOT11(9), ACYP1(2), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ECHS1(4), EHHADH(15), ESCO1(22), ESCO2(18), FN3K(1), GCDH(8), HADHA(12), ITGB1BP3(1), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6), YOD1(3)	17500620	214	122	190	71	53	43	28	51	38	1	0.407	1.000	1.000
385	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(27), IFNA1(8), IFNB1(6), IKBKB(9), IL1A(1), IL1B(5), IL1R1(7), IL1RAP(7), IL1RN(7), IL6(7), IRAK1(6), IRAK2(11), IRAK3(11), JUN(2), MAP2K3(11), MAP2K6(5), MAP3K1(21), MAP3K14(6), MAP3K7(9), MAPK14(8), MAPK8(17), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2), TOLLIP(5), TRAF6(4)	19825512	242	122	224	68	76	43	25	64	34	0	0.0748	1.000	1.000
386	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(12), DLG4(10), EPHB2(16), F2(10), F2RL1(8), F2RL2(8), JUN(2), MAP2K5(6), MAPK1(3), MAPK7(6), MAPK8(17), MYEF2(14), PLD1(19), PLD2(10), PLD3(7), PTK2(24), RAF1(16), RASAL1(9), SRC(3), TEC(10), VAV1(24)	18732351	234	122	218	86	79	52	28	50	25	0	0.548	1.000	1.000
387	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(15), AGT(12), AGTR1(14), AGTR2(17), ANPEP(19), CMA1(1), CPA3(5), CTSA(6), CTSG(5), ENPEP(24), LNPEP(23), MAS1(3), MME(27), NLN(13), REN(10), THOP1(6)	14399905	214	121	194	54	52	38	26	60	38	0	0.0172	1.000	1.000
388	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(81), EP300(56), ESR1(21), MAPK1(3), MAPK3(4), PELP1(11), SRC(3)	10143037	179	121	157	75	46	47	21	34	31	0	0.809	1.000	1.000
389	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(7), IL6R(8), JAK1(22), JAK2(55), JAK3(31), PIAS3(10), PTPRU(24), REG1A(8), SRC(3), STAT3(10)	10374426	180	121	148	66	56	57	23	21	19	4	0.556	1.000	1.000
390	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(14), AZIN1(3), BTG1(2), CBX3(7), CLOCK(24), CRY1(17), CRY2(5), DNAJA1(5), EIF4G2(16), ETV6(11), GFRA1(17), GSTM3(6), GSTP1(1), HERPUD1(3), HSPA8(13), IDI1(4), KLF9(1), MYF6(7), NCKAP1(17), NCOA4(9), NR1D2(10), PER1(13), PER2(9), PIGF(1), PPP1R3C(6), PPP2CB(4), PSMA4(3), SF3A3(1), SUMO3(1), TOB1(8), TUBB3(10), UCP3(3), UGP2(12), VAPA(2), ZFR(21)	24979942	286	120	243	76	76	42	25	78	62	3	0.167	1.000	1.000
391	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(7), ARSB(10), FUCA1(7), FUCA2(5), GALNS(6), GBA(4), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE(11), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NAGLU(6), NEU1(6), NEU2(6), NEU3(2), SPAM1(13)	21886047	248	120	228	85	78	58	23	60	29	0	0.307	1.000	1.000
392	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(7), CDK7(3), ERCC3(19), GTF2A2(1), GTF2B(12), GTF2E1(13), GTF2E2(1), GTF2F2(1), GTF2H1(6), GTF2H4(3), ILK(3), MNAT1(4), POLR1A(15), POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3B(14), POLR3D(5), POLR3E(13), POLR3H(2), POLR3K(2), TAF12(4), TAF13(3), TAF5(13), TAF6(9), TAF7(3), TAF9(3), TBP(2)	24399525	217	120	200	79	60	36	28	50	43	0	0.716	1.000	1.000
393	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), BAX(16), BCL2(2), CASP8(20), CYCS(1), FADD(1), MAP2K1(12), MAP2K4(36), MAP3K1(21), MAPK1(3), MAPK3(4), MAPK8(17), NFKB1(11), NSMAF(13), RAF1(16), RELA(10), RIPK1(7), SMPD1(10), TNFRSF1A(4), TRAF2(8)	13898538	213	119	181	58	60	36	27	44	44	2	0.0571	1.000	1.000
394	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(14), EPHA4(26), EPHB1(38), FYN(17), ITGA1(12), ITGB1(13), L1CAM(17), LYN(13), RAP1B(2), SELP(15)	10545769	167	118	153	56	52	34	31	31	18	1	0.135	1.000	1.000
395	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	33	ARSD(9), ARSE(4), ASAH1(4), B4GALT6(10), CERK(3), DEGS1(3), ENPP7(3), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SGMS1(6), SGMS2(8), SGPP1(8), SGPP2(6), SMPD1(10), SMPD2(3), SMPD3(4), SMPD4(9), SPHK1(3), SPHK2(5), SPTLC1(12), SPTLC2(9), UGCG(9), UGT8(12)	21682977	235	118	223	87	72	41	34	53	34	1	0.443	1.000	1.000
396	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), ESRRA(35), HDAC5(14), MEF2A(7), MEF2C(15), MEF2D(3), PPARA(7), PPP3CA(5), PPP3CB(11), PPP3CC(7), SLC2A4(8), SYT1(14), YWHAH(5)	13757657	185	118	148	73	49	33	13	36	54	0	0.955	1.000	1.000
397	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(4), ACAD9(8), ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6)	16773466	208	117	185	76	44	50	26	57	30	1	0.632	1.000	1.000
398	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(13), FOS(5), GRB2(11), HRAS(4), IL3(6), JAK2(55), MAP2K1(12), MAPK3(4), PTPN6(4), RAF1(16), SHC1(14), SOS1(16), STAT5A(10), STAT5B(20)	11504029	190	117	150	60	46	63	17	29	31	4	0.421	1.000	1.000
399	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(11), ADRBK2(11), ARRB2(1), CALM2(1), CALM3(1), CALML3(2), CALML6(1), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CLCA1(14), CLCA2(11), CLCA4(15), CNGA3(17), CNGA4(14), CNGB1(15), GNAL(5), GUCA1A(3), GUCA1B(4), GUCA1C(3), PDC(4), PDE1C(19), PRKACA(2), PRKACB(5), PRKACG(9), PRKG1(18), PRKG2(12), PRKX(3)	21422132	228	115	218	107	64	34	31	64	35	0	0.978	1.000	1.000
400	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(2), DLAT(10), DLD(4), DLST(4), FH(10), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), OGDH(14), PC(16), PDHA1(8), PDHA2(17), PDHB(3), PDHX(3), PDK1(7), PDK2(9), PDK3(6), PDK4(6), PDP2(6), SDHA(14), SDHB(3), SDHD(4), SUCLA2(9), SUCLG1(3), SUCLG2(1)	19541091	203	115	186	81	64	33	26	51	29	0	0.761	1.000	1.000
401	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(27), FADD(1), IKBKB(9), IKBKG(2), IL1A(1), IL1R1(7), IRAK1(6), MAP3K1(21), MAP3K14(6), MAP3K7(9), MYD88(4), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TLR4(18), TNF(2), TNFAIP3(42), TNFRSF1A(4), TNFRSF1B(1), TRAF6(4)	16109182	193	115	178	62	46	55	18	44	30	0	0.253	1.000	1.000
402	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), LTA(1), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), RIPK1(7), TANK(8), TNFAIP3(42), TNFRSF1B(1), TRAF1(7), TRAF2(8), TRAF3(12)	15452709	195	115	173	64	52	55	20	34	34	0	0.206	1.000	1.000
403	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(5), CSF1R(16), DDX20(7), E2F4(2), ETS1(10), ETS2(5), ETV3(5), FOS(5), HDAC2(8), HDAC5(14), HRAS(4), JUN(2), NCOR2(44), RBL1(21), RBL2(24), SIN3A(28), SIN3B(10)	17145408	210	114	183	80	55	41	20	42	52	0	0.872	1.000	1.000
404	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	12	IL10RA(4), IL22(2), IL22RA1(3), IL22RA2(3), JAK1(22), JAK2(55), JAK3(31), STAT1(17), STAT3(10), STAT5A(10), STAT5B(20), TYK2(5)	12278247	182	114	148	65	38	62	14	34	30	4	0.803	1.000	1.000
405	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(24), CALM2(1), CALM3(1), CAPN2(10), CAPNS1(4), CAPNS2(4), EP300(56), HDAC1(5), HDAC2(8), MEF2D(3), NFATC2(12), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SYT1(14)	15300958	173	114	153	73	50	35	22	32	34	0	0.825	1.000	1.000
406	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(22), JAK2(55), JAK3(31), PIAS1(4), PIAS3(10), PTPRU(24), REG1A(8), SOAT1(6)	9167754	162	114	136	58	47	56	17	19	19	4	0.511	1.000	1.000
407	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(12), ACO2(7), CS(2), DLD(4), DLST(4), FH(10), IDH1(21), IDH2(17), IDH3A(5), IDH3G(4), MDH1(8), MDH2(3), PC(16), PCK1(6), SDHA(14), SDHB(3), SUCLA2(9), SUCLG1(3), SUCLG2(1)	14089335	149	113	137	55	42	28	21	38	20	0	0.494	1.000	1.000
408	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(10), F2R(11), GNAI1(5), GNB1(3), GNGT1(1), HRAS(4), ITGA1(12), ITGB1(13), MAP2K1(12), MAPK1(3), MAPK3(4), PLA2G4A(16), PLCB1(23), PRKCA(8), PTGS1(10), PTK2(24), RAF1(16), SRC(3), SYK(8), TBXAS1(13)	16933598	199	113	179	83	68	43	27	40	21	0	0.803	1.000	1.000
409	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(10), ABAT(8), ADSL(13), ADSS(8), AGXT(8), AGXT2(9), ASL(5), ASNS(3), ASPA(8), CAD(23), CRAT(11), DARS(5), DDO(6), GAD1(17), GAD2(15), GOT1(7), GOT2(2), GPT(7), GPT2(4), NARS(5), PC(16)	17503229	190	112	176	73	64	24	30	47	25	0	0.674	1.000	1.000
410	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(12), AKR1D1(9), ARSB(10), ARSD(9), ARSE(4), CYP11B1(17), CYP11B2(7), HSD11B1(2), HSD11B2(1), HSD17B2(7), HSD17B3(6), HSD17B8(5), HSD3B1(6), HSD3B2(4), SRD5A1(2), SRD5A2(2), STS(12), SULT1E1(6), SULT2A1(6), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10)	18613178	201	112	182	55	69	30	23	39	40	0	0.0221	1.000	1.000
411	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(10), DYRK1B(14), GLI2(28), GLI3(44), GSK3B(17), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SHH(3), SMO(13), SUFU(5)	10475187	169	112	154	71	60	38	14	30	27	0	0.691	1.000	1.000
412	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(27), GNAS(39), GNB1(3), GNGT1(1), PPP2CA(3), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAG2(7), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	10150157	159	111	134	47	68	31	8	31	21	0	0.118	1.000	1.000
413	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(14), ACTN1(13), ACTN2(19), ACTN3(6), CAPN1(2), CAPNS1(4), CAPNS2(4), ITGA1(12), ITGB1(13), ITGB3(16), PTK2(24), PXN(2), RAC1(2), SPTAN1(30), SRC(3), TLN1(23)	19208856	187	111	180	96	60	31	23	45	26	2	0.997	1.000	1.000
414	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C8B(23), C9(12), MASP1(23)	16668527	202	110	192	65	59	26	22	52	41	2	0.515	1.000	1.000
415	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(75), MAP2(60), PPP1CA(2), PPP2CA(3), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6), PRKCE(6)	12641543	175	109	151	56	36	40	23	39	37	0	0.395	1.000	1.000
416	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(11), CHIT1(12), CMAS(9), CTBS(6), CYB5R1(4), CYB5R3(2), GFPT1(6), GFPT2(12), GNE(8), GNPDA1(2), GNPDA2(3), GNPNAT1(1), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), NAGK(7), NANS(2), NPL(4), PGM3(7), PHPT1(2), RENBP(3), UAP1(6)	19707803	200	109	191	56	74	36	24	38	28	0	0.0434	1.000	1.000
417	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(12), BAIAP2(7), CASP1(6), CASP3(4), CASP7(3), CASP8(20), GAPDH(2), INSR(21), ITCH(7), MAGI1(31), MAGI2(32), RERE(15), WWP1(21), WWP2(9)	16031074	190	109	176	70	53	31	28	38	39	1	0.659	1.000	1.000
418	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(27), ARHGAP5(51), ARHGDIB(5), CASP1(6), CASP10(7), CASP3(4), CASP8(20), CASP9(6), CYCS(1), GZMB(5), JUN(2), PRF1(8)	8953161	142	108	98	34	21	45	12	23	41	0	0.0814	1.000	1.000
419	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(11), AP2A1(5), AP2M1(6), ARF1(1), BAD(1), BTK(12), EEA1(19), GRASP(3), GSK3A(6), GSK3B(17), LYN(13), PDPK1(4), PFKL(7), PFKM(5), PFKP(16), PLCG1(19), PRKCE(6), PRKCZ(4), RAB5A(4), RAC1(2), RPS6KB1(9), VAV2(20)	16443107	190	108	173	63	57	39	26	37	30	1	0.328	1.000	1.000
420	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(5), DAB1(16), FYN(17), LRP8(5), RELN(95), VLDLR(15)	9756132	156	107	129	50	41	38	17	39	21	0	0.116	1.000	1.000
421	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(27), ARHGDIB(5), BIRC2(7), BIRC3(18), CASP1(6), CASP10(7), CASP2(8), CASP3(4), CASP4(11), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), GZMB(5), LMNA(1), LMNB1(11), LMNB2(3), PRF1(8)	13214043	162	106	135	55	30	36	14	44	38	0	0.763	1.000	1.000
422	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(27), DUSP1(7), IKBKAP(15), IKBKB(9), IKBKG(2), MAP3K1(21), MAP3K14(6), NFKB1(11), NFKBIA(1), RELA(10), TNFAIP3(42), TRAF3(12), TRAF6(4)	12705040	167	106	149	51	41	47	16	32	31	0	0.193	1.000	1.000
423	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(19), GTF2A1(6), GTF2B(12), GTF2E1(13), GTF2F1(7), HDAC3(3), NCOA1(15), NCOA2(23), NCOA3(21), NCOR2(44), POLR2A(14), RARA(6), RXRA(8), TBP(2)	16178934	193	106	169	85	59	29	29	37	39	0	0.975	1.000	1.000
424	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(10), CARS(11), DARS(5), EPRS(27), FARS2(7), GARS(8), HARS(6), IARS(10), KARS(8), LARS(13), LARS2(6), MARS(16), MARS2(6), NARS(5), QARS(14), RARS(9), SARS(6), TARS(10), WARS(4), WARS2(7), YARS(4)	22744531	192	105	186	44	58	26	28	52	28	0	0.0199	1.000	1.000
425	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG3(4), ATG5(10), ATG7(1), BECN1(3), GABARAPL1(1), IFNA1(8), IFNA10(5), IFNA13(3), IFNA14(5), IFNA16(4), IFNA17(2), IFNA2(10), IFNA21(2), IFNA4(5), IFNA5(5), IFNA6(4), IFNA7(2), IFNA8(3), IFNG(3), PIK3C3(29), PIK3R4(21), PRKAA1(9), PRKAA2(20), ULK2(14), ULK3(3)	13629670	176	105	154	48	26	46	24	54	25	1	0.116	1.000	1.000
426	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12), MASP1(23), MASP2(10), MBL2(3)	17012866	192	104	183	67	54	22	21	51	42	2	0.740	1.000	1.000
427	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(24), CPOX(4), EPRS(27), FECH(4), GUSB(4), HCCS(4), HMBS(5), HMOX1(6), HMOX2(5), PPOX(5), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10), UROD(3), UROS(5)	18782028	175	104	156	46	43	30	23	40	39	0	0.187	1.000	1.000
428	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), FPGT(10), GCK(6), GMDS(5), GMPPA(11), HK1(13), HK2(7), HK3(22), KHK(4), MPI(4), PFKFB1(14), PFKFB3(3), PFKFB4(5), PFKM(5), PFKP(16), PMM1(5), PMM2(2), SORD(2), TPI1(3)	16348521	170	102	157	61	64	24	16	45	21	0	0.450	1.000	1.000
429	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(16), ALDOC(3), DERA(4), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKL(7), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1(9), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TALDO1(4), TKT(7), TKTL1(8), TKTL2(15)	15779471	174	102	162	58	58	30	25	46	15	0	0.168	1.000	1.000
430	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(8), CARM1(3), CBS(4), CTH(6), GGT1(11), HEMK1(1), LCMT1(1), LCMT2(6), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), METTL2B(3), METTL6(8), PAPSS1(5), PAPSS2(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), SCLY(12), SEPHS1(7), SEPHS2(5), WBSCR22(2)	16478016	167	102	156	51	42	27	23	41	34	0	0.196	1.000	1.000
431	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	16	CALM2(1), CALM3(1), CDKN1A(2), GNAQ(11), NFATC2(12), NFATC3(15), NFATC4(12), PLCG1(19), PPP3CA(5), PPP3CB(11), PPP3CC(7), PRKCA(8), SP1(7), SP3(13), SYT1(14)	13023936	138	101	124	59	43	33	13	25	24	0	0.839	1.000	1.000
432	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(8), AMD1(4), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTAP(3), MTFMT(1), MTR(14), SRM(1), TAT(16)	14116545	174	101	161	57	66	21	26	33	27	1	0.248	1.000	1.000
433	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(44), APOA1(3), APOA4(6), APOC1(1), APOC2(2), APOE(1), CETP(12), CYP7A1(14), DGAT1(5), HMGCR(7), LCAT(4), LDLR(11), LIPC(6), LPL(12), LRP1(53), SCARB1(4), SOAT1(6)	18004821	191	101	181	71	65	30	25	48	23	0	0.546	1.000	1.000
434	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(3), ASRGL1(1), CA1(3), CA12(3), CA13(2), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUD2(22), GLUL(5), HAL(12)	14785991	161	100	152	58	50	29	19	38	25	0	0.631	1.000	1.000
435	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(27), ADRB2(3), GNAS(39), PLCE1(34), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), RAP2B(3)	9500104	141	100	121	34	57	31	7	32	14	0	0.00902	1.000	1.000
436	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(22), JAK2(55), JAK3(31), MAPK1(3), MAPK3(4), STAT3(10), TYK2(5)	7857135	130	100	103	49	27	56	10	19	14	4	0.769	1.000	1.000
437	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(5), CSNK1D(15), DRD1(9), DRD2(9), GRM1(37), PLCB1(23), PPP1CA(2), PPP1R1B(1), PPP2CA(3), PPP3CA(5), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6)	10797443	147	99	133	54	50	35	7	33	22	0	0.565	1.000	1.000
438	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(16), GABRA1(19), GABRA2(17), GABRA3(7), GABRA4(22), GABRA5(21), GABRA6(22), GPHN(18), NSF(4), SRC(3), UBQLN1(6)	8469740	155	99	140	47	40	22	17	51	25	0	0.205	1.000	1.000
439	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(25), ABCC2(23), ABCG2(17), BCHE(29), CES1(14), CES2(3), CYP3A4(9), CYP3A5(3), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10)	16348309	184	98	161	57	48	32	27	44	32	1	0.165	1.000	1.000
440	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(11), CD2(7), CD3D(5), CD3E(2), CD3G(16), CD4(4), CXCR3(5), IFNG(3), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), JAK2(55), STAT4(13), TYK2(5)	10281667	154	98	121	55	18	56	20	32	25	3	0.724	1.000	1.000
441	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(27), BIRC2(7), BIRC3(18), CASP10(7), CASP3(4), CASP7(3), CASP8(20), CASP9(6), DFFA(6), DFFB(2), GZMB(5), PRF1(8), SCAP(9), SREBF1(8), SREBF2(10)	11809219	140	98	120	47	28	25	16	38	33	0	0.596	1.000	1.000
442	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(5), ALOX5(12), CYP1A2(11), CYP2C18(9), CYP2C19(12), CYP2C8(11), CYP2C9(11), CYP2E1(11), CYP2J2(3), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), HSD3B7(3), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), RDH11(4), RDH12(7), RDH13(4), RDH14(1)	16709635	177	96	169	62	62	35	18	48	13	1	0.325	1.000	1.000
443	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), B4GALNT1(13), GLB1(9), HEXA(4), HEXB(5), LCT(46), SLC33A1(10), ST3GAL1(3), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(14), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(6), ST8SIA1(10), ST8SIA5(10)	11266988	151	96	129	53	53	33	13	32	20	0	0.470	1.000	1.000
444	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME3(8), PGK1(3), PGK2(10), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TKTL1(8), TKTL2(15), TPI1(3)	13626489	150	96	140	58	45	22	17	49	17	0	0.667	1.000	1.000
445	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), DDOST(4), DPAGT1(14), DPM1(3), FUT8(11), MAN1A1(14), MAN1B1(7), MGAT1(9), MGAT3(11), MGAT4A(7), MGAT4B(8), MGAT5(14), RPN1(4), RPN2(7), ST6GAL1(3)	12685384	151	96	136	52	43	33	17	30	28	0	0.679	1.000	1.000
446	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(1), CCR1(8), CCR2(7), CCR3(11), CCR4(3), CCR5(11), CCR7(7), CD28(5), CD4(4), CXCR3(5), CXCR4(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18R1(16), IL2(5), IL4(5), IL4R(6), TGFB1(2), TGFB2(10), TGFB3(2)	14143712	159	96	145	62	34	37	21	45	21	1	0.641	1.000	1.000
447	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), G6PD(14), GPI(6), H6PD(8), PFKM(5), PFKP(16), PGD(7), PGM1(10), PGM3(7), PRPS1(9), PRPS1L1(4), PRPS2(6), RBKS(2), RPE(4), RPIA(4), TAL1(3), TALDO1(4), TKT(7)	13375468	143	96	130	47	47	26	17	41	12	0	0.216	1.000	1.000
448	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(7), CREBBP(81), DFFA(6), DFFB(2), GZMA(11), GZMB(5), HMGB2(2), NME1(1), PRF1(8), SET(6)	7165757	130	96	119	51	34	31	14	31	20	0	0.666	1.000	1.000
449	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(3), IFNGR1(8), JAK1(22), JAK2(55), PTPRU(24), REG1A(8), STAT1(17)	7960983	139	96	118	47	41	50	8	21	14	5	0.484	1.000	1.000
450	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(27), ADRB2(3), CFTR(21), GNAS(39), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), SLC9A3R1(3)	8463733	128	95	108	35	51	27	6	29	15	0	0.0556	1.000	1.000
451	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	ABO(7), B3GNT1(5), B3GNT2(5), B3GNT3(2), B3GNT4(4), B3GNT5(3), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), FUT9(10), GCNT2(26), ST3GAL6(16), ST8SIA1(10)	9215862	142	95	131	33	48	20	11	41	21	1	0.0228	1.000	1.000
452	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSB(10), ARSD(9), ARSE(4), ASAH1(4), GAL3ST1(3), GALC(5), GBA(4), GLA(7), GLB1(9), LCT(46), NEU1(6), NEU2(6), NEU3(2), PPAP2A(2), PPAP2B(2), PPAP2C(3), SMPD1(10), SMPD2(3), SPTLC1(12), SPTLC2(9), UGCG(9)	15097703	165	94	155	62	50	30	22	43	20	0	0.538	1.000	1.000
453	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UGDH(9), UGP2(12), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2A1(11), UGT2A3(17), UGT2B10(2), UGT2B11(12), UGT2B15(3), UGT2B17(7), UGT2B28(13), UGT2B4(10), UGT2B7(9), XYLB(6)	17778277	187	94	169	46	33	30	23	55	46	0	0.143	1.000	1.000
454	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(11), GRB2(11), IL2RG(9), IL4(5), IL4R(6), IRS1(21), JAK1(22), JAK3(31), RPS6KB1(9), SHC1(14), STAT6(4)	9532244	143	94	112	37	34	32	17	21	37	2	0.177	1.000	1.000
455	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(8), GALNT2(15), GALNT3(15), GALNT6(12), GALNT7(7), GALNT8(5), GALNT9(10), GCNT1(9), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), WBSCR17(39)	9918089	132	94	127	45	59	20	16	18	19	0	0.274	1.000	1.000
456	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(4), ANXA2(5), ANXA3(5), ANXA4(6), ANXA5(3), ANXA6(8), CYP11A1(7), EDN1(3), EDNRA(9), EDNRB(19), HPGD(1), HSD11B1(2), HSD11B2(1), PLA2G4A(16), PRL(4), PTGDR(9), PTGDS(2), PTGER2(2), PTGER4(4), PTGFR(8), PTGIR(2), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	14267644	160	93	151	58	59	18	14	46	23	0	0.566	1.000	1.000
457	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(6), CR1(20), CR2(22), FCGR2B(2), HLA-DRA(12), HLA-DRB1(7), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	9761682	148	92	146	47	35	23	23	35	29	3	0.376	1.000	1.000
458	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(27), CREM(10), FHL5(11), FSHB(6), FSHR(19), GNAS(39), XPO1(9)	6175525	121	92	95	32	50	29	9	24	9	0	0.0841	1.000	1.000
459	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(11), F13A1(15), F2(10), F2R(11), FGA(23), FGB(6), FGG(7), PLAT(11), PLAU(7), PLG(27), SERPINB2(10), SERPINE1(10)	9577865	148	92	137	52	41	26	25	33	23	0	0.490	1.000	1.000
460	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	16	ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), HGSNAT(7), HPSE(11), HPSE2(23), HYAL1(4), HYAL2(2), IDS(5), LCT(46), NAGLU(6), SPAM1(13)	13451262	166	92	148	54	52	37	15	43	19	0	0.279	1.000	1.000
461	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(20), EXT2(3), EXTL1(7), EXTL2(8), EXTL3(14), GLCE(8), HS2ST1(5), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(6), HS6ST2(5), HS6ST3(6), NDST1(10), NDST2(10), NDST3(19), NDST4(13)	13840841	152	92	147	57	58	29	13	34	18	0	0.646	1.000	1.000
462	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(1), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), ILVBL(9), PANK1(7), PANK2(1), PANK3(7), PANK4(8), PPCS(4), UPB1(9), VNN1(13)	11358523	151	92	141	46	32	29	28	44	17	1	0.132	1.000	1.000
463	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(5), CHAT(17), DBH(9), DDC(5), GAD1(17), GAD2(15), HDC(14), MAOA(7), PAH(17), PNMT(3), SLC18A3(12), TPH1(4)	9026307	127	90	119	54	42	19	12	44	10	0	0.746	1.000	1.000
464	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), JAK2(55), TYK2(5)	7151025	113	90	90	44	20	55	4	22	8	4	0.741	1.000	1.000
465	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(6), IL13RA2(17), IL4R(6), JAK1(22), JAK2(55), TYK2(5)	7151025	113	90	90	44	20	55	4	22	8	4	0.741	1.000	1.000
466	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(7), CHUK(27), IFNG(3), IKBKB(9), IL2(5), IL4(5), JUN(2), MAP3K1(21), MAP3K5(16), MAP4K5(4), MAPK14(8), MAPK8(17), NFKB1(11), NFKBIA(1), RELA(10), TNFRSF9(10), TRAF2(8)	13368999	164	89	147	40	44	41	16	44	19	0	0.0246	1.000	1.000
467	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(16), ALDOC(3), FBP1(1), FBP2(5), GOT1(7), GOT2(2), GPT(7), GPT2(4), MDH1(8), MDH2(3), ME1(14), ME2(9), ME3(8), PGK1(3), PKLR(12), PKM2(4), RPE(4), RPIA(4), TKT(7), TPI1(3)	12129487	126	89	116	46	35	20	15	40	16	0	0.548	1.000	1.000
468	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(19), CD2(7), CD33(3), CD5(9), CD7(6), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL3(6), IL4(5), ITGAX(18), TLR2(12), TLR4(18), TLR7(18), TLR9(16)	12701615	161	89	149	61	52	24	17	50	16	2	0.545	1.000	1.000
469	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2B1(11), MAN2B2(9), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2)	12938978	142	89	134	52	46	36	15	31	14	0	0.421	1.000	1.000
470	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(14), CLOCK(24), CRY1(17), CRY2(5), CSNK1D(15), CSNK1E(9), NPAS2(10), NR1D1(8), PER1(13), PER2(9), PER3(20)	11433966	144	89	116	31	45	29	10	33	25	2	0.00806	1.000	1.000
471	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(8), BHMT(10), CBS(4), CTH(6), DNMT1(28), DNMT3A(23), DNMT3B(20), MARS(16), MARS2(6), MAT1A(8), MAT2B(6), MTR(14)	11950916	149	89	139	46	57	20	19	27	25	1	0.207	1.000	1.000
472	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(22), AP2A1(5), AP2M1(6), BIN1(6), CALM2(1), CALM3(1), DNM1(16), EPN1(10), EPS15(14), NME1(1), PICALM(9), PPP3CA(5), PPP3CB(11), PPP3CC(7), SYNJ1(28), SYNJ2(15), SYT1(14)	15355004	171	89	155	70	48	30	17	44	32	0	0.798	1.000	1.000
473	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(27), MAP3K14(6), MAPK14(8), MAPK8(17), NFKB1(11), RELA(10), TNFRSF13B(7), TNFRSF17(4), TNFSF13(2), TNFSF13B(4), TRAF2(8), TRAF3(12), TRAF5(13), TRAF6(4)	9700198	133	89	120	38	44	29	10	25	25	0	0.211	1.000	1.000
474	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(10), AGPAT6(4), AGPS(6), CHPT1(4), ENPP2(27), ENPP6(11), PAFAH1B1(6), PAFAH1B3(2), PAFAH2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(4), PLA2G4A(16), PLA2G5(1), PLA2G6(10), PLD1(19), PLD2(10), PPAP2A(2), PPAP2B(2), PPAP2C(3)	16146603	163	88	153	72	57	30	21	37	18	0	0.931	1.000	1.000
475	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(27), BAK1(2), BAX(16), BCL2(2), BCL2L1(1), BID(2), BIK(1), BIRC2(7), BIRC3(18), CASP3(4), CASP6(3), CASP7(3), CASP8(20), CASP9(6), CYCS(1), DFFA(6), DFFB(2), DIABLO(3), ENDOG(3)	9412726	127	88	98	32	20	19	17	31	39	1	0.352	1.000	1.000
476	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGAM(14), ITGB1(13), ITGB2(18), PECAM1(4), SELE(13), SELL(5), SELP(15)	10704712	133	88	137	44	41	23	14	31	24	0	0.313	1.000	1.000
477	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(5), ADH1B(10), ADH1C(4), ADH4(2), ADH5(7), ADH6(9), ADH7(7), ADHFE1(9), ALDH1A3(20), ALDH1B1(10), ALDH2(12), ALDH3A1(7), ALDH3A2(11), ALDH7A1(8), ALDH9A1(4)	9027693	125	87	109	34	29	31	19	31	15	0	0.0634	1.000	1.000
478	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), ESCO1(22), ESCO2(18), MYST3(34), MYST4(33), NAT6(2), PNPLA3(6), SH3GLB1(6)	11082560	143	86	125	51	34	32	15	37	24	1	0.663	1.000	1.000
479	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(15), BST1(3), C9orf95(2), CD38(5), ENPP1(17), ENPP3(12), NADK(8), NADSYN1(4), NMNAT1(3), NMNAT2(5), NMNAT3(5), NNMT(6), NNT(8), NT5C(1), NT5C1A(7), NT5C1B(13), NT5C2(12), NT5C3(5), NT5E(7), NT5M(3), NUDT12(3), QPRT(2)	15172522	146	86	139	52	45	27	17	36	20	1	0.362	1.000	1.000
480	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(2), C1QB(2), C1R(6), C1S(17), C2(10), C3(25), C4A(3), C4B(2), C5(25), C6(27), C7(11), C8A(14), C9(12)	14305523	156	85	147	50	44	16	16	39	39	2	0.659	1.000	1.000
481	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(16), PGAP1(14), PIGA(3), PIGB(3), PIGC(4), PIGF(1), PIGG(12), PIGH(1), PIGK(12), PIGM(8), PIGN(7), PIGO(14), PIGP(2), PIGQ(6), PIGS(8), PIGT(4), PIGU(3), PIGV(5), PIGW(2), PIGX(4), PIGZ(6)	16362410	139	84	130	57	24	30	13	44	28	0	0.933	1.000	1.000
482	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(3), CA1(3), CA12(3), CA14(4), CA2(4), CA3(5), CA4(4), CA5A(2), CA5B(2), CA6(7), CA7(6), CA8(6), CA9(11), CPS1(39), CTH(6), GLS(2), GLS2(6), GLUD1(4), GLUL(5), HAL(12)	13277194	136	84	127	51	41	26	17	29	23	0	0.731	1.000	1.000
483	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), CMBL(1), CYP3A4(9), CYP3A43(6), CYP3A5(3), CYP3A7(11), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), PON1(12), PON2(7), PON3(14)	11598072	139	83	126	46	37	31	14	34	21	2	0.351	1.000	1.000
484	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(7), CAT(8), EPX(14), LPO(10), MPO(17), MTHFR(9), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36)	7671411	118	83	106	32	54	14	13	21	16	0	0.0871	1.000	1.000
485	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(7), ATP6V0C(1), CAT(8), EPX(14), LPO(10), MPO(17), PRDX1(3), PRDX2(2), PRDX5(2), PRDX6(5), SHMT1(7), SHMT2(5), TPO(36)	7751352	117	83	105	34	55	14	13	18	17	0	0.106	1.000	1.000
486	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CALM3(1), CCL4(1), CCR5(11), CXCL12(2), CXCR4(7), FOS(5), GNAQ(11), JUN(2), MAPK14(8), MAPK8(17), PLCG1(19), PRKCA(8), PTK2B(13), SYT1(14)	9455777	120	82	108	51	26	31	9	36	18	0	0.944	1.000	1.000
487	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), CDKN1A(2), EPO(1), EPOR(2), GRIN1(5), HIF1A(16), JAK2(55), NFKB1(11), NFKBIA(1), RELA(10), SOD2(4)	8654048	116	82	100	47	24	44	13	17	15	3	0.727	1.000	1.000
488	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(13), ERBB4(65), NRG2(8), NRG3(18), PRKCA(8), PSEN1(4)	6360313	116	82	106	39	23	22	20	34	17	0	0.448	1.000	1.000
489	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(10), F2R(11), F3(2), F5(37), F7(7), FGA(23), FGB(6), FGG(7), PROC(3), PROS1(12), SERPINC1(8), TFPI(9)	11211396	140	82	131	54	37	29	20	38	16	0	0.723	1.000	1.000
490	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(6), ALDH18A1(8), ARG1(2), ARG2(6), ASL(5), CKB(1), CKM(7), CKMT1B(2), CKMT2(10), CPS1(39), GAMT(6), GATM(2), GLUD1(4), NAGS(6), OAT(4), ODC1(8), OTC(17), SMS(4)	11898702	137	81	127	38	39	29	19	33	17	0	0.0859	1.000	1.000
491	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(3), IFNGR1(8), IFNGR2(5), JAK1(22), JAK2(55), STAT1(17)	5876778	110	80	91	40	22	47	4	21	11	5	0.632	1.000	1.000
492	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(6), ACADM(12), ACADS(4), ACADVL(6), ACSL1(9), ACSL3(12), ACSL4(10), CPT1A(13), CPT2(3), DCI(4), EHHADH(15), HADHA(12), SCP2(6), SLC25A20(2)	11733185	114	80	103	44	29	21	15	31	18	0	0.588	1.000	1.000
493	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(7), FUCA1(7), FUCA2(5), GLB1(9), HEXA(4), HEXB(5), LCT(46), MAN2C1(12), MANBA(13), NEU1(6), NEU2(6), NEU3(2)	10562813	122	80	115	37	37	31	14	26	14	0	0.145	1.000	1.000
494	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(4), DPYD(42), DPYS(12), ENPP1(17), ENPP3(12), PANK1(7), PANK2(1), PANK3(7), PANK4(8), PPCS(4), UPB1(9)	9038743	128	80	119	35	22	25	24	39	17	1	0.0833	1.000	1.000
495	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), FDXR(5), SHMT1(7)	11185039	120	79	102	41	34	28	15	24	19	0	0.499	1.000	1.000
496	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(14), ACTR2(2), ACTR3(5), ARPC1A(9), ARPC1B(5), ARPC2(5), ARPC3(2), ARPC4(1), NCK1(1), NCKAP1(17), NTRK1(17), PIR(2), PSMA7(2), RAC1(2), WASF1(6), WASF2(5), WASF3(17), WASL(18)	10790657	130	78	123	44	36	16	19	36	23	0	0.488	1.000	1.000
497	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10716841	115	78	97	40	33	27	15	22	18	0	0.538	1.000	1.000
498	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(11), FOS(5), HRAS(4), JUN(2), MAP2K1(12), MAPK1(3), MAPK3(4), MYC(5), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RAF1(16), RELA(10), TNF(2)	10407445	117	78	106	48	39	21	19	22	16	0	0.658	1.000	1.000
499	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10716841	115	78	97	40	33	27	15	22	18	0	0.538	1.000	1.000
500	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(14), APAF1(27), BCL2(2), CASP3(4), CASP9(6), CYCS(1), DAXX(18), FAS(9), FASLG(3), HSPB2(3), IL1A(1), MAPKAPK2(5), MAPKAPK3(6), TNF(2)	7422406	101	78	81	37	18	30	13	17	23	0	0.755	1.000	1.000
501	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(4), CSF1(5), CSF3(3), HLA-DRA(12), HLA-DRB1(7), IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL11(6), IL12A(2), IL12B(1), IL13(2), IL15(1), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL7(4), IL8(6), LTA(1), PDGFA(2), TGFB1(2), TGFB2(10), TGFB3(2), TNF(2)	8864156	115	78	105	46	34	22	10	31	14	4	0.765	1.000	1.000
502	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(36), CPT1A(13), LEP(1), LEPR(21), PRKAA1(9), PRKAA2(20), PRKAB1(5), PRKAB2(5), PRKAG1(5), PRKAG2(7)	10370628	122	78	115	36	38	14	12	39	19	0	0.407	1.000	1.000
503	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(35), ABCB11(19), ABCB4(28), ABCC1(25), ABCC3(11), GSTP1(1)	9746347	119	78	123	37	23	20	18	32	24	2	0.409	1.000	1.000
504	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(4), ATP6AP1(6), ATP6V0A1(7), ATP6V0A4(17), ATP6V0B(3), ATP6V0C(1), ATP6V0D1(6), ATP6V1A(13), ATP6V1B1(17), ATP6V1B2(2), ATP6V1C1(4), ATP6V1C2(6), ATP6V1D(5), ATP6V1E1(1), ATP6V1F(1), ATP6V1G1(1), ATP6V1G2(4), ATP6V1G3(4), ATP6V1H(6), SHMT1(7)	10716841	115	78	97	40	33	27	15	22	18	0	0.538	1.000	1.000
505	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(39), GNB1(3), GNGT1(1), PRKACB(5), PRKACG(9), PRKAR1A(8), PRKAR1B(3), PRKAR2A(4), PRKAR2B(6), PRKCA(8)	6294507	90	77	73	33	39	21	2	16	12	0	0.475	1.000	1.000
506	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	15	B3GNT1(5), B3GNT2(5), B3GNT7(6), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT4(2), CHST1(10), CHST2(13), CHST4(8), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	7278265	103	77	101	36	51	17	4	17	14	0	0.596	1.000	1.000
507	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(27), BAD(1), BAK1(2), BAX(16), BCL10(8), BCL2(2), BCL2L1(1), BCL2L11(4), BID(2), CASP8AP2(30), CASP9(6), CES1(14)	7117379	113	77	92	31	21	10	19	23	38	2	0.650	1.000	1.000
508	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(5), CD3D(5), CD3E(2), CD3G(16), IFNG(3), IL2(5), IL2RA(6), IL4(5), TGFB1(2), TGFB2(10), TGFB3(2), TGFBR1(20), TGFBR2(26), TGFBR3(17), TOB1(8), TOB2(2)	7485633	134	77	106	39	38	29	14	23	30	0	0.247	1.000	1.000
509	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(25), C5(25), C6(27), C7(11), C8A(14), C9(12)	8778922	114	75	107	35	35	11	13	30	24	1	0.385	1.000	1.000
510	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(4), ALOX15(5), ALOX15B(11), ALOX5(12), ALOX5AP(1), DPEP1(3), GGT1(11), LTA4H(2), PLA2G6(10), PTGDS(2), PTGES(1), PTGIS(7), PTGS1(10), PTGS2(10), TBXAS1(13)	9867332	102	75	94	37	34	11	12	22	23	0	0.596	1.000	1.000
511	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(1), IARS(10), IARS2(19), ILVBL(9), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3), VARS(7), VARS2(9)	11405023	107	75	105	41	42	17	14	19	15	0	0.723	1.000	1.000
512	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	64	FAU(2), MRPL13(8), MRPS7(4), RPL10A(3), RPL10L(4), RPL11(3), RPL12(1), RPL13A(1), RPL14(2), RPL18A(3), RPL19(2), RPL21(1), RPL23A(1), RPL24(2), RPL27(1), RPL27A(1), RPL28(3), RPL3(6), RPL31(4), RPL32(2), RPL34(1), RPL35(5), RPL37A(2), RPL39(2), RPL3L(6), RPL6(4), RPL7(4), RPL8(3), RPL9(4), RPS10(2), RPS11(2), RPS13(2), RPS15A(1), RPS16(2), RPS18(2), RPS2(3), RPS20(1), RPS23(3), RPS24(1), RPS25(1), RPS26(2), RPS27(1), RPS3(4), RPS5(2), RPS6(3), RPS7(1), RPS9(3), RPSA(1)	13694342	122	75	117	32	29	27	20	31	15	0	0.152	1.000	1.000
513	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(15), POLR1B(16), POLR1C(4), POLR1D(7), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLR3A(17), POLR3B(14), POLR3G(1), POLR3GL(3), POLR3H(2), POLR3K(2)	16195591	124	75	119	31	38	17	25	27	17	0	0.0476	1.000	1.000
514	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(7), CD28(5), CD3D(5), CD3E(2), CD3G(16), CD8A(2), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	7285886	116	75	98	39	28	16	14	22	36	0	0.651	1.000	1.000
515	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(5), CD86(2), HLA-DRA(12), HLA-DRB1(7), IFNG(3), IFNGR1(8), IFNGR2(5), IL12A(2), IL12B(1), IL12RB1(5), IL12RB2(20), IL18(3), IL18R1(16), IL2(5), IL2RA(6), IL4(5), IL4R(6)	8555833	111	75	101	33	27	23	15	26	16	4	0.170	1.000	1.000
516	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(7), CD28(5), CD3D(5), CD3E(2), CD3G(16), CD4(4), ICAM1(4), ITGAL(21), ITGB2(18), PTPRC(36)	7747156	118	75	100	41	26	16	16	23	37	0	0.729	1.000	1.000
517	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(10), ARFGEF2(24), CLTA(6), CLTB(3), COPA(14), GBF1(19), GPLD1(16), KDELR1(5), KDELR2(9), KDELR3(2)	11408612	110	74	106	39	31	21	14	22	22	0	0.652	1.000	1.000
518	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(8), ACP5(5), ACP6(6), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), LHPP(6), MTMR1(13), MTMR2(8), MTMR6(11), PHPT1(2), RFK(1), TYR(12)	10560919	120	74	107	38	35	30	14	22	17	2	0.292	1.000	1.000
519	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(13), KHK(4), LCT(46), MPI(4), PGM1(10), PYGL(8), PYGM(12), TPI1(3), TREH(6)	9210110	106	73	98	34	34	22	15	28	7	0	0.170	1.000	1.000
520	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(10), GALNS(6), GLB1(9), GNS(11), GUSB(4), HEXA(4), HEXB(5), IDS(5), LCT(46), NAGLU(6)	9533781	106	73	97	37	39	21	10	25	11	0	0.315	1.000	1.000
521	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(6), ICAM1(4), ITGA4(20), ITGAL(21), ITGB1(13), ITGB2(18), PECAM1(4), SELE(13), SELL(5)	8281894	104	73	104	38	27	19	10	26	22	0	0.625	1.000	1.000
522	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(6), POLD1(20), POLD2(2), POLE(41), POLG(9), POLL(2), POLQ(42)	11478171	122	71	108	39	37	15	21	31	18	0	0.356	1.000	1.000
523	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(21), ESR2(8), ITPKA(3), PDE1A(10), PDE1B(11), PLCB1(23), PLCB2(11), PRL(4), TRH(8), VIP(3)	7534369	102	71	94	39	28	19	15	24	16	0	0.677	1.000	1.000
524	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(9), CYB5R3(2), GCK(6), GFPT1(6), GNE(8), GNPDA1(2), GNPDA2(3), HEXA(4), HEXB(5), HK1(13), HK2(7), HK3(22), PGM3(7), RENBP(3), UAP1(6)	11659061	103	70	97	31	35	24	12	19	13	0	0.192	1.000	1.000
525	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(13), AMT(2), ATIC(14), DHFR(1), FTCD(5), GART(5), MTFMT(1), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6)	12911227	107	70	101	51	33	17	16	22	17	2	0.944	1.000	1.000
526	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(2), FH(10), IDH2(17), MDH1(8), OGDH(14), SDHA(14), SUCLA2(9)	6549626	81	69	71	29	22	15	8	22	14	0	0.581	1.000	1.000
527	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(6), JAK1(22), PTPRU(24), REG1A(8), STAT1(17), STAT2(12), TYK2(5)	8526878	101	69	92	27	39	21	8	18	14	1	0.133	1.000	1.000
528	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(12), AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), CYP21A2(12), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	5959809	85	68	70	29	32	12	7	15	19	0	0.584	1.000	1.000
529	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(14), EIF2AK4(23), EIF2B5(15), EIF2S1(3), EIF2S2(2), EIF2S3(3), EIF5(6), GSK3B(17), PPP1CA(2)	7874754	85	68	72	21	14	31	6	15	19	0	0.136	1.000	1.000
530	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(9), CYSLTR2(18), GPR109B(5), GPR161(13), GPR171(11), GPR18(5), GPR34(11), GPR39(4), GPR45(14), GPR65(2), GPR68(5), GPR75(10)	6794550	107	68	93	44	30	21	7	29	19	1	0.841	1.000	1.000
531	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(12), AKR1D1(9), CYP11A1(7), CYP11B1(17), CYP11B2(7), CYP17A1(8), CYP21A2(12), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	5959809	85	68	70	29	32	12	7	15	19	0	0.584	1.000	1.000
532	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(6), B3GAT2(1), B3GAT3(2), B4GALT7(2), CHPF(10), CHST11(6), CHST12(6), CHST14(1), CHST3(7), CHSY1(14), DSE(10), UST(12), XYLT1(14), XYLT2(15)	8544270	106	68	88	51	41	16	12	18	18	1	0.953	1.000	1.000
533	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(2), BNIP1(5), GOSR1(5), GOSR2(6), SEC22B(3), SNAP23(2), SNAP25(2), SNAP29(4), STX11(7), STX12(6), STX16(7), STX17(2), STX18(3), STX19(4), STX2(6), STX3(4), STX4(3), STX5(11), STX6(2), STX7(4), STX8(7), TSNARE1(5), USE1(2), VAMP1(1), VAMP2(1), VAMP3(4), VAMP4(4), VAMP5(3), VAMP8(1), VTI1A(6), VTI1B(1), YKT6(1)	11075338	124	68	111	35	39	12	11	29	33	0	0.381	1.000	1.000
534	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(3), DHRS1(4), DHRS2(6), DHRS3(2), DHRS7(10), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2)	9410902	88	67	89	34	19	21	9	26	13	0	0.734	1.000	1.000
535	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(13), AMT(2), ATIC(14), ATP6V0C(1), DHFR(1), GART(5), MTHFD1(9), MTHFD1L(13), MTHFD2(2), MTHFR(9), MTHFS(1), MTR(14), SHMT1(7), SHMT2(5), TYMS(6)	12541796	102	67	94	49	30	18	15	21	16	2	0.941	1.000	1.000
536	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(3), DHCR24(2), DHCR7(4), EBP(6), FDFT1(4), FDPS(6), GGCX(11), GGPS1(5), HMGCR(7), IDI1(4), IDI2(3), LSS(5), MVD(3), MVK(16), NQO1(1), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2), TM7SF2(2)	12916653	108	66	97	41	33	8	14	28	25	0	0.891	1.000	1.000
537	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC2(3), PSMC3(10), PSMD1(19), PSMD11(8), PSMD12(6), PSMD13(8), PSMD2(4), PSMD6(8)	11487542	97	66	88	37	25	24	11	25	12	0	0.728	1.000	1.000
538	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(4), RPE(4), UCHL1(2), UCHL3(2), UGDH(9), UGT1A1(3), UGT1A10(1), UGT1A3(10), UGT1A4(8), UGT1A5(6), UGT1A6(8), UGT1A7(8), UGT1A8(7), UGT1A9(10), UGT2B15(3), UGT2B4(10)	11835122	102	66	88	30	27	14	13	18	30	0	0.450	1.000	1.000
539	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(19), CKM(7), FBL(6), GPT(7), LDHA(14), LDHB(8), LDHC(4), MAPK14(8), NCL(12)	6045227	85	65	74	33	21	21	12	24	7	0	0.641	1.000	1.000
540	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(3), EPO(1), FLT3(36), IGF1(6), IL11(6), IL1A(1), IL3(6), IL6(7), IL9(2), KITLG(3), TGFB1(2), TGFB2(10), TGFB3(2)	5817287	85	64	75	40	21	21	7	23	12	1	0.940	1.000	1.000
541	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(4), EHHADH(15), HADH(2), HADHA(12), HSD17B10(3), HSD17B4(9), NTAN1(10), SIRT1(8), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(5)	8175711	78	63	68	26	22	11	10	14	21	0	0.547	1.000	1.000
542	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(11), CYP2A13(12), CYP2A6(14), CYP2A7(17), NAT1(1), NAT2(3), XDH(19)	5673381	77	62	72	34	25	13	10	21	8	0	0.858	1.000	1.000
543	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), CHPT1(4), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(3), METTL6(8), PCYT1A(5), PCYT1B(7), PRMT2(7), PRMT3(7), PRMT5(7), PRMT6(2), PRMT7(7), PRMT8(12), WBSCR22(2)	9317773	82	62	85	36	19	18	9	23	13	0	0.915	1.000	1.000
544	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(6), IL10(2), IL10RA(4), IL10RB(7), IL1A(1), IL6(7), JAK1(22), STAT1(17), STAT3(10), STAT5A(10), TNF(2)	8331374	92	62	80	35	30	16	6	22	17	1	0.735	1.000	1.000
545	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CALM3(1), CAMK1(9), CAMK1G(7), CAMK2A(4), CAMK2B(4), CAMK2D(8), CAMK2G(11), CAMK4(9), CAMKK1(2), CAMKK2(9), CREB1(3), SYT1(14)	7873843	82	61	74	39	21	21	9	17	14	0	0.929	1.000	1.000
546	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), IMPA2(4), ISYNA1(6), PGM1(10), PGM3(7), TGDS(1)	7573819	80	61	75	33	33	12	8	18	9	0	0.607	1.000	1.000
547	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(8), IFNAR1(7), IFNAR2(4), IFNB1(6), JAK1(22), STAT1(17), STAT2(12), TYK2(5)	7400082	81	61	70	24	22	18	6	21	13	1	0.355	1.000	1.000
548	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(13), ADSS(8), DHFR(1), HPRT1(2), IMPDH1(4), MTHFD2(2), POLB(6), POLD1(20), POLG(9), PRPS2(6), RRM1(3), SRM(1)	8300600	75	61	74	31	28	7	12	14	14	0	0.783	1.000	1.000
549	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(3), DFFA(6), DFFB(2), ENDOG(3), GZMB(5), HMGB1(2), HMGB2(2), TOP2A(24), TOP2B(25)	6083306	76	60	71	18	10	15	8	22	21	0	0.439	1.000	1.000
550	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(14), CAPN1(2), CAPNS1(4), CAPNS2(4), CDK5(3), CDK5R1(5), CSNK1A1(3), CSNK1D(15), GSK3B(17), MAPT(11), PPP2CA(3)	5698340	81	60	77	27	29	20	5	17	10	0	0.413	1.000	1.000
551	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(8), IFNB1(6), IFNG(3), IL10(2), IL12A(2), IL12B(1), IL13(2), IL15(1), IL16(18), IL18(3), IL1A(1), IL2(5), IL3(6), IL4(5), IL6(7), IL8(6), IL9(2), LTA(1), TNF(2)	6679783	81	59	72	43	23	16	8	25	9	0	0.954	1.000	1.000
552	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(12), ACO2(7), AFMID(3), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2)	9484795	83	59	76	26	25	10	13	24	11	0	0.242	1.000	1.000
553	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(15), CD38(5), ENPP1(17), ENPP3(12), NADSYN1(4), NMNAT1(3), NMNAT2(5), NNMT(6), NNT(8), NT5C(1), NT5E(7), NT5M(3), QPRT(2)	10368086	88	59	81	32	24	19	10	22	12	1	0.425	1.000	1.000
554	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(6), CSF1(5), FCGR3A(5), IL1B(5), IL6R(8), SELL(5), SPN(6), TGFB1(2), TGFB2(10), TNF(2), TNFRSF1A(4), TNFRSF1B(1), TNFRSF8(8), TNFSF8(6)	8798591	87	59	89	29	26	12	16	19	14	0	0.272	1.000	1.000
555	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(18), CCNA2(4), CCND1(2), CCNE1(6), CCNE2(3), CDK2(5), CDK4(4), CDKN1B(6), CDKN2A(9), E2F2(7), E2F4(2), PRB1(5)	5854733	71	59	67	30	15	14	9	19	14	0	0.783	1.000	1.000
556	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(12), ACO2(7), CS(2), GRHPR(2), HAO1(11), HAO2(9), HYI(2), MDH1(8), MDH2(3), MTHFD1(9), MTHFD1L(13), MTHFD2(2)	9047504	80	58	73	24	24	10	13	22	11	0	0.201	1.000	1.000
557	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(5), FOSL1(1), FOSL2(5), IFNAR1(7), IFNAR2(4), IFNB1(6), MAPK8(17), NFKB1(11), RELA(10), TNFRSF11A(6), TNFSF11(8), TRAF6(4)	7427319	84	58	82	32	25	17	9	18	15	0	0.615	1.000	1.000
558	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(11), CDC25B(11), CDK7(3), CDKN1A(2), CHEK1(11), NEK1(20), WEE1(15)	4831657	73	58	64	26	11	19	5	19	18	1	0.833	1.000	1.000
559	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(11), CDC25B(11), CDC25C(6), CSK(5), GRB2(11), PRKCA(8), PTPRA(6), SRC(3)	6378948	69	58	64	25	17	20	7	20	5	0	0.476	1.000	1.000
560	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(16), ENO1(3), GPI(6), HK1(13), PFKL(7), PGAM1(4), PGK1(3), PKLR(12), TPI1(3)	5847539	67	57	59	29	22	13	5	20	7	0	0.833	1.000	1.000
561	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(6), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST3GAL4(4), ST8SIA1(10)	6419614	77	56	76	26	24	10	8	23	12	0	0.514	1.000	1.000
562	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(6), B3GALNT1(6), B3GALT5(5), FUT1(11), FUT2(7), FUT9(10), GBGT1(1), GLA(7), HEXA(4), HEXB(5), NAGA(8), ST3GAL1(3), ST3GAL2(1), ST8SIA1(10)	6872877	84	56	81	28	30	10	9	23	12	0	0.434	1.000	1.000
563	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMC3(10), PSMD14(2), RPN1(4), RPN2(7), UBE2A(5), UBE3A(25)	9226684	84	56	82	30	21	17	11	23	12	0	0.570	1.000	1.000
564	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(11), GNB1(3), GNGT1(1), HTR2C(15), PLCB1(23), TUB(14)	4961287	71	56	70	30	27	13	7	18	6	0	0.764	1.000	1.000
565	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(5), GSR(5), GSS(9), IL8(6), NFKB1(11), NOX1(4), RELA(10), TNF(2), XDH(19)	6903227	71	55	66	23	17	22	7	11	14	0	0.457	1.000	1.000
566	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(8), ME1(14), PC(16), PDHA1(8), SLC25A1(1), SLC25A11(2)	6057386	63	55	57	21	23	15	7	11	7	0	0.344	1.000	1.000
567	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(9), CAMK1G(7), HDAC9(20), MEF2A(7), MEF2C(15), MEF2D(3), YWHAH(5)	4818752	66	55	74	32	21	9	3	22	10	1	0.956	1.000	1.000
568	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(5), CHAT(17), CHKA(6), PCYT1A(5), PDHA1(8), PDHA2(17), PEMT(2), SLC18A3(12)	4591510	72	54	70	43	30	9	10	18	5	0	0.968	1.000	1.000
569	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(6), FARSB(12), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4), YARS2(7)	6150246	78	53	71	25	19	8	12	27	12	0	0.474	1.000	1.000
570	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(8), B4GALT2(7), B4GALT3(8), B4GALT5(5), FUT8(11), ST3GAL1(3), ST3GAL2(1), ST3GAL3(12), ST3GAL4(4)	5223575	64	53	59	19	26	14	3	12	9	0	0.439	1.000	1.000
571	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(6), HK1(13), HK2(7), HK3(22), IMPA1(4), PGM1(10), PGM3(7), TGDS(1)	6907599	70	53	65	29	28	11	7	17	7	0	0.652	1.000	1.000
572	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(28), GNA12(7), PRKACB(5), PRKACG(9), PRKAG1(5), PRKAR2A(4), PRKAR2B(6)	7123468	64	52	60	17	17	10	7	17	13	0	0.286	1.000	1.000
573	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(7), B3GALT1(3), B3GALT2(10), B3GALT5(5), B3GNT5(3), FUT1(11), FUT2(7), FUT3(6), ST3GAL3(12), ST3GAL4(4)	4700899	68	52	64	25	31	7	4	15	11	0	0.675	1.000	1.000
574	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(11), NFKB1(11), NFKBIA(1), PLCB1(23), PRKCA(8), RELA(10)	5746565	64	52	61	28	21	12	7	15	9	0	0.840	1.000	1.000
575	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	13	POLR1B(16), POLR2A(14), POLR2B(14), POLR2C(2), POLR2D(3), POLR2E(2), POLR2F(3), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(1), POLRMT(14)	8476258	73	51	71	20	26	13	8	16	10	0	0.273	1.000	1.000
576	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), IDI1(4), LSS(5), MVD(3), MVK(16), NQO1(1), NQO2(3), PMVK(2), SC5DL(9), SQLE(2)	7185377	66	50	56	20	20	8	8	15	15	0	0.436	1.000	1.000
577	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(8), ACP5(5), ACPP(4), ACPT(3), ENPP1(17), ENPP3(12), FLAD1(7), RFK(1), TYR(12)	6843528	74	49	65	20	20	19	9	15	9	2	0.146	1.000	1.000
578	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(6), FARS2(7), GOT1(7), GOT2(2), PAH(17), TAT(16), YARS(4)	5934868	65	48	59	28	15	7	14	20	9	0	0.857	1.000	1.000
579	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(5), UBE2A(5), UBE2B(3), UBE2C(4), UBE2D1(1), UBE2D2(1), UBE2D3(1), UBE2E1(4), UBE2E3(1), UBE2G1(3), UBE2G2(1), UBE2H(2), UBE2I(4), UBE2J2(3), UBE2L3(5), UBE2M(2), UBE2N(1), UBE2S(1), UBE3A(25)	7020427	74	48	72	22	20	13	6	17	18	0	0.275	1.000	1.000
580	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(4), FDFT1(4), FDPS(6), HMGCR(7), HMGCS1(1), IDI1(4), LSS(5), MVD(3), MVK(16), NSDHL(2), PMVK(2), SC4MOL(3), SC5DL(9), SQLE(2)	8736823	71	47	62	23	21	7	8	18	17	0	0.639	1.000	1.000
581	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(4), ECHS1(4), HADH(2), HADHA(12), HADHB(10), HSD17B10(3), HSD17B4(9), MECR(4), PPT1(1), PPT2(5)	5881095	54	47	53	18	14	9	6	13	12	0	0.456	1.000	1.000
582	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(10), LARS(13), LARS2(6), PDHA1(8), PDHA2(17), PDHB(3)	7048795	62	46	61	27	20	11	9	14	8	0	0.859	1.000	1.000
583	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(15), APOBEC1(7), APOBEC2(3), APOBEC3A(3), APOBEC3B(4), APOBEC3C(6), APOBEC3F(2), APOBEC3G(8), APOBEC4(9)	5191508	57	44	56	17	22	5	10	10	10	0	0.312	1.000	1.000
584	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14), XYLT2(15)	3963660	51	43	39	24	19	7	2	8	14	1	0.974	1.000	1.000
585	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(2), HS3ST1(4), HS3ST2(8), HS3ST3A1(2), HS3ST3B1(4), XYLT1(14), XYLT2(15)	3963660	51	43	39	24	19	7	2	8	14	1	0.974	1.000	1.000
586	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(11), NDUFA4(3), NDUFA5(1), NDUFA8(1), NDUFB2(3), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(16), NDUFS2(6), NDUFV1(5), NDUFV2(3)	4996405	57	43	55	15	17	6	5	10	19	0	0.269	1.000	1.000
587	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(5), CPS1(39), GLS(2), GLUD1(4), GOT1(7)	5422364	59	43	52	16	14	14	10	14	7	0	0.214	1.000	1.000
588	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(3), FOS(5), JUN(2), KEAP1(5), MAPK1(3), MAPK14(8), MAPK8(17), NFE2L2(7), PRKCA(8)	5625930	58	42	57	24	13	12	5	20	8	0	0.803	1.000	1.000
589	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(11), MBTPS1(14), MBTPS2(2), SCAP(9), SREBF1(8), SREBF2(10)	7338535	55	42	54	28	16	13	8	10	8	0	0.839	1.000	1.000
590	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	13	BPNT1(9), CHST11(6), CHST12(6), PAPSS1(5), PAPSS2(7), SULT1A1(4), SULT1A2(4), SULT1E1(6), SULT2A1(6), SULT2B1(4), SUOX(5)	6526346	62	41	58	21	20	9	5	20	8	0	0.560	1.000	1.000
591	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(3), FOS(5), FYN(17), JUN(2), MAPK14(8), THBS1(14)	5017622	53	41	48	20	14	9	6	11	13	0	0.587	1.000	1.000
592	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(12), AOC3(10), CES1(14), ESD(5)	4004121	45	39	44	23	15	6	8	11	5	0	0.869	1.000	1.000
593	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(7), FUT1(11), FUT2(7), FUT3(6), FUT5(3), FUT6(2), ST3GAL3(12)	2690635	48	39	45	19	26	5	3	9	5	0	0.593	1.000	1.000
594	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(7), SEC61A2(4), SRP19(1), SRP54(4), SRP68(13), SRP72(9), SRPR(13)	5300023	51	39	42	13	11	7	7	13	13	0	0.471	1.000	1.000
595	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(19), PRKCA(8), PTK2B(13)	4596991	48	39	44	26	15	12	6	9	6	0	0.967	1.000	1.000
596	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(8), F13B(12), HSD17B1(2), HSD17B2(7), HSD17B3(6), HSD17B4(9), HSD3B1(6), HSD3B2(4)	5650953	54	39	52	23	18	10	7	13	6	0	0.646	1.000	1.000
597	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	5	DBH(9), GAD1(17), HDC(14), PNMT(3), TPH1(4)	3543730	47	38	45	19	14	7	3	18	5	0	0.718	1.000	1.000
598	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(11), CYP2E1(11), NR1I3(5), PTGS1(10), PTGS2(10)	3714878	47	37	47	19	22	4	8	9	4	0	0.722	1.000	1.000
599	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(10), CYP11A1(7), CYP11B2(7), CYP17A1(8), HSD11B1(2), HSD11B2(1), HSD3B1(6), HSD3B2(4)	4653077	45	37	43	26	18	7	7	7	6	0	0.916	1.000	1.000
600	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(11), NR1H3(16), NR1H4(9), RXRA(8)	3464000	46	36	39	21	14	9	6	6	11	0	0.904	1.000	1.000
601	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(12), ALAS2(12), CPOX(4), FECH(4), HMBS(5), PPOX(5), UROD(3), UROS(5)	5397606	51	36	47	13	21	8	5	11	6	0	0.344	1.000	1.000
602	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(6), ACADM(12), ACADS(4), ACAT1(7), ECHS1(4), HADHA(12)	3709116	45	35	43	19	12	6	6	8	13	0	0.746	1.000	1.000
603	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(5), GOT1(7), GOT2(2), TAT(16), TYR(12)	3360193	42	35	34	22	11	6	11	11	3	0	0.911	1.000	1.000
604	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(2), PSMA2(6), PSMA3(5), PSMA4(3), PSMA5(3), PSMA6(1), PSMA7(2), PSMB2(2), PSMB3(2), PSMB5(3), PSMB6(2), PSMB8(9), PSMB9(4)	5875820	44	35	43	19	9	5	5	17	8	0	0.855	1.000	1.000
605	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(7), ACAT2(9), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(1), HMGCS2(6), OXCT1(3), OXCT2(3)	5121005	36	33	34	14	13	6	3	7	7	0	0.701	1.000	1.000
606	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(7), CSF1(5), IL6(7), LDLR(11), LPL(12)	3651205	42	33	39	19	14	12	3	7	6	0	0.692	1.000	1.000
607	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(12), NR3C1(11), PPARG(4), RETN(2), RXRA(8), TNF(2)	3753014	41	33	37	25	10	8	8	8	7	0	0.970	1.000	1.000
608	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(9), ALPP(8), ALPPL2(2), DHFR(1), FPGS(4), GGH(2), SPR(7)	3636482	37	32	37	15	12	7	5	9	4	0	0.609	1.000	1.000
609	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(10), PRKCA(8), TGM2(17)	3400591	41	31	40	21	17	6	3	12	3	0	0.853	1.000	1.000
610	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(5), IL1B(5), MST1(5), MST1R(14), TNF(2)	3518329	31	28	28	11	11	5	4	8	3	0	0.496	1.000	1.000
611	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(8), ARG1(2), GLS(2), GLUD1(4), OAT(4), PRODH(5)	3682869	25	23	24	12	11	7	2	1	4	0	0.760	1.000	1.000
612	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(12), SNAP25(2), STX1A(4), VAMP2(1)	2245011	23	23	20	11	7	6	3	6	1	0	0.907	1.000	1.000
613	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(7), GOT2(2), TAT(16)	1889276	25	21	19	13	7	1	9	5	3	0	0.867	1.000	1.000
614	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(7), ACAT2(9), HMGCL(1), OXCT1(3)	2416096	20	18	18	10	3	5	3	5	4	0	0.890	1.000	1.000
615	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(6), IFNG(3), IL12A(2), IL12B(1), IL18(3), IL2(5)	2128698	20	15	19	16	1	4	6	7	2	0	0.995	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	365947	1	1	1	2	1	0	0	0	0	0	0.955	1.000	1.000