E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.033 0.025 -9999.0 0.0 -0.467 1.0 1.0 KLHL20 -0.019 0.054 -9999.0 0.0 -0.232 30.0 30.0 CYFIP2 0.001 0.079 -9999.0 0.0 -0.59 11.0 11.0 Rac1/GDP 0.044 0.039 -9999.0 0.0 -0.492 1.0 1.0 ENAH 0.026 0.052 -9999.0 0.0 -0.488 2.0 2.0 AP1M1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 RAP1B 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.004 0.032 -9999.0 0.0 -0.416 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.041 -9999.0 0.0 -0.206 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.012 0.073 -9999.0 0.0 -0.328 22.0 22.0 RAPGEF1 0.04 0.032 -9999.0 0.0 -0.45 2.0 2.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.027 0.026 -9999.0 0.0 -0.485 1.0 1.0 CRK 0.037 0.028 -9999.0 0.0 -0.434 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.021 0.031 -9999.0 0.0 -0.36 4.0 4.0 alphaE/beta7 Integrin -0.004 0.092 -9999.0 0.0 -0.393 32.0 32.0 IQGAP1 0.009 0.039 -9999.0 0.0 -0.543 3.0 3.0 NCKAP1 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 Rap1/GTP/I-afadin 0.021 0.024 -9999.0 0.0 -0.328 3.0 3.0 DLG1 0.031 0.033 -9999.0 0.0 -0.467 1.0 1.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.003 0.026 -9999.0 0.0 -0.259 5.0 5.0 MLLT4 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 ARF6/GTP/NME1/Tiam1 -0.011 0.095 -9999.0 0.0 -0.277 69.0 69.0 PI3K -0.004 0.034 -9999.0 0.0 -0.342 5.0 5.0 ARF6 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.016 0.025 -9999.0 0.0 -0.428 2.0 2.0 TIAM1 -0.045 0.165 -9999.0 0.0 -0.517 67.0 67.0 E-cadherin(dimer)/Ca2+ 0.026 0.023 -9999.0 0.0 -0.303 3.0 3.0 AKT1 -0.003 0.023 -9999.0 0.0 -0.236 4.0 4.0 PIK3R1 0.008 0.042 -9999.0 0.0 -0.59 3.0 3.0 CDH1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 RhoA/GDP 0.043 0.04 -9999.0 0.0 -0.492 1.0 1.0 actin cytoskeleton organization 0.017 0.052 -9999.0 0.0 -0.2 8.0 8.0 CDC42/GDP 0.042 0.047 -9999.0 0.0 -0.43 2.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.019 0.023 -9999.0 0.0 -0.266 4.0 4.0 ITGB7 -0.017 0.122 -9999.0 0.0 -0.537 32.0 32.0 RAC1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.028 0.024 -9999.0 0.0 -0.322 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.019 0.023 -9999.0 0.0 -0.309 3.0 3.0 mol:GDP 0.041 0.044 -9999.0 0.0 -0.605 1.0 1.0 CDC42/GTP/IQGAP1 0.011 0.049 -9999.0 0.0 -0.46 6.0 6.0 JUP 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 p120 catenin/RhoA/GDP 0.035 0.04 -9999.0 0.0 -0.499 1.0 1.0 RAC1/GTP/IQGAP1 0.014 0.024 -9999.0 0.0 -0.332 3.0 3.0 PIP5K1C/AP1M1 0.016 0.032 -9999.0 0.0 -0.785 1.0 1.0 RHOA 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 CDC42 0.007 0.054 -9999.0 0.0 -0.59 5.0 5.0 CTNNA1 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 positive regulation of S phase of mitotic cell cycle 0.016 0.037 -9999.0 0.0 -0.264 2.0 2.0 NME1 0.011 0.018 -9999.0 0.0 -0.45 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.032 0.028 -9999.0 0.0 -0.467 1.0 1.0 regulation of cell-cell adhesion -0.004 0.028 -9999.0 0.0 -0.357 2.0 2.0 WASF2 -0.008 0.021 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.003 0.026 -9999.0 0.0 -0.451 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.016 0.073 -9999.0 0.0 -0.303 25.0 25.0 CCND1 0.018 0.044 -9999.0 0.0 -0.336 2.0 2.0 VAV2 0.008 0.155 -9999.0 0.0 -0.688 29.0 29.0 RAP1/GDP 0.036 0.035 -9999.0 0.0 -0.494 1.0 1.0 adherens junction assembly 0.032 0.027 -9999.0 0.0 -0.452 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 PIP5K1C 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.022 0.07 -9999.0 0.0 -0.407 1.0 1.0 E-cadherin/beta catenin -0.0 0.022 -9999.0 0.0 -0.357 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.032 0.028 -9999.0 0.0 -0.467 1.0 1.0 PIK3CA 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 Rac1/GTP -0.031 0.088 -9999.0 0.0 -0.38 30.0 30.0 E-cadherin/beta catenin/alpha catenin 0.022 0.027 -9999.0 0.0 -0.36 3.0 3.0 ITGAE 0.011 0.018 -9999.0 0.0 -0.45 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.027 -9999.0 0.0 -0.496 1.0 1.0