Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.052 0.223 -9999.0 0.0 -0.639 56.0 56.0 IHH -0.039 0.169 -9999.0 0.0 -0.632 44.0 44.0 SHH Np/Cholesterol/GAS1 -0.085 0.162 -9999.0 0.0 -0.308 200.0 200.0 LRPAP1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 dorsoventral neural tube patterning 0.085 0.161 0.306 200.0 -9999.0 0.0 200.0 SMO/beta Arrestin2 -0.039 0.197 -9999.0 0.0 -0.62 42.0 42.0 SMO -0.047 0.208 -9999.0 0.0 -0.576 59.0 59.0 AKT1 -0.005 0.111 -9999.0 0.0 -0.461 14.0 14.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.032 0.139 -9999.0 0.0 -0.475 55.0 55.0 ADRBK1 0.01 0.03 -9999.0 0.0 -0.52 2.0 2.0 heart looping -0.045 0.204 -9999.0 0.0 -0.565 59.0 59.0 STIL -0.028 0.167 -9999.0 0.0 -0.603 31.0 31.0 DHH N/PTCH2 -0.041 0.156 -9999.0 0.0 -0.433 80.0 80.0 DHH N/PTCH1 -0.048 0.173 -9999.0 0.0 -0.539 34.0 34.0 PIK3CA 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 DHH -0.03 0.146 -9999.0 0.0 -0.544 46.0 46.0 PTHLH -0.079 0.3 -9999.0 0.0 -0.935 56.0 56.0 determination of left/right symmetry -0.045 0.204 -9999.0 0.0 -0.565 59.0 59.0 PIK3R1 0.008 0.042 -9999.0 0.0 -0.59 3.0 3.0 skeletal system development -0.078 0.296 -9999.0 0.0 -0.921 56.0 56.0 IHH N/Hhip -0.084 0.205 -9999.0 0.0 -0.467 129.0 129.0 DHH N/Hhip -0.079 0.19 -9999.0 0.0 -0.425 134.0 134.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.204 -9999.0 0.0 -0.565 59.0 59.0 pancreas development -0.079 0.207 -9999.0 0.0 -0.547 101.0 101.0 HHAT 0.004 0.068 -9999.0 0.0 -0.59 8.0 8.0 PI3K 0.013 0.04 -9999.0 0.0 -0.43 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.136 0.24 -9999.0 0.0 -0.517 174.0 174.0 somite specification -0.045 0.204 -9999.0 0.0 -0.565 59.0 59.0 SHH Np/Cholesterol/PTCH1 -0.035 0.175 -9999.0 0.0 -0.622 33.0 33.0 SHH Np/Cholesterol/PTCH2 -0.025 0.119 -9999.0 0.0 -0.322 82.0 82.0 SHH Np/Cholesterol/Megalin -0.023 0.106 -9999.0 0.0 -0.289 81.0 81.0 SHH -0.011 0.11 -9999.0 0.0 -0.418 42.0 42.0 catabolic process -0.033 0.166 -9999.0 0.0 -0.435 61.0 61.0 SMO/Vitamin D3 -0.042 0.199 -9999.0 0.0 -0.64 43.0 43.0 SHH Np/Cholesterol/Hhip -0.054 0.153 -9999.0 0.0 -0.335 130.0 130.0 LRP2 -0.026 0.116 -9999.0 0.0 -0.45 43.0 43.0 receptor-mediated endocytosis -0.045 0.193 -9999.0 0.0 -0.594 47.0 47.0 SHH Np/Cholesterol/BOC -0.026 0.118 -9999.0 0.0 -0.3 90.0 90.0 SHH Np/Cholesterol/CDO -0.009 0.102 -9999.0 0.0 -0.338 51.0 51.0 mesenchymal cell differentiation 0.054 0.152 0.333 130.0 -9999.0 0.0 130.0 mol:Vitamin D3 -0.033 0.177 -9999.0 0.0 -0.625 33.0 33.0 IHH N/PTCH2 -0.043 0.16 -9999.0 0.0 -0.438 82.0 82.0 CDON -0.001 0.079 -9999.0 0.0 -0.52 14.0 14.0 IHH N/PTCH1 -0.033 0.168 -9999.0 0.0 -0.44 61.0 61.0 Megalin/LRPAP1 -0.01 0.084 -9999.0 0.0 -0.315 44.0 44.0 PTCH2 -0.028 0.144 -9999.0 0.0 -0.545 44.0 44.0 SHH Np/Cholesterol -0.01 0.085 -9999.0 0.0 -0.325 42.0 42.0 PTCH1 -0.033 0.167 -9999.0 0.0 -0.437 61.0 61.0 HHIP -0.08 0.208 -9999.0 0.0 -0.548 101.0 101.0