Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.036 -9999.0 0.0 -0.258 10.0 10.0 epithelial cell differentiation -0.001 0.021 -9999.0 0.0 -0.301 3.0 3.0 CYFIP2 0.001 0.079 -9999.0 0.0 -0.59 11.0 11.0 ENAH 0.037 0.067 -9999.0 0.0 -0.431 6.0 6.0 EGFR 0.005 0.058 -9999.0 0.0 -0.53 7.0 7.0 EPHA2 0.006 0.055 -9999.0 0.0 -0.543 6.0 6.0 MYO6 0.029 0.022 -9999.0 0.0 -0.283 3.0 3.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.015 0.06 -9999.0 0.0 -0.386 13.0 13.0 AQP5 -0.036 0.1 -9999.0 0.0 -0.472 26.0 26.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.025 -9999.0 0.0 -0.28 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.094 -9999.0 0.0 -0.288 49.0 49.0 EGF -0.179 0.252 -9999.0 0.0 -0.507 228.0 228.0 NCKAP1 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 AQP3 -0.021 0.065 -9999.0 0.0 -0.472 8.0 8.0 cortical microtubule organization -0.001 0.021 -9999.0 0.0 -0.301 3.0 3.0 GO:0000145 0.026 0.024 -9999.0 0.0 -0.267 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.023 -9999.0 0.0 -0.303 3.0 3.0 MLLT4 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 ARF6/GDP -0.005 0.038 -9999.0 0.0 -0.495 2.0 2.0 ARF6 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.045 -9999.0 0.0 -0.375 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.03 -9999.0 0.0 -0.52 2.0 2.0 ZYX 0.028 0.025 -9999.0 0.0 -0.284 4.0 4.0 ARF6/GTP 0.027 0.047 -9999.0 0.0 -0.395 6.0 6.0 CDH1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 EGFR/EGFR/EGF/EGF -0.084 0.111 -9999.0 0.0 -0.379 2.0 2.0 RhoA/GDP -0.002 0.022 -9999.0 0.0 -0.282 4.0 4.0 actin cytoskeleton organization 0.032 0.026 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.01 0.024 -9999.0 0.0 -0.589 1.0 1.0 GIT1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 IGF1R 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 IGF1 -0.074 0.197 -9999.0 0.0 -0.523 99.0 99.0 DIAPH1 -0.013 0.091 -9999.0 0.0 -0.623 13.0 13.0 Wnt receptor signaling pathway 0.001 0.021 0.301 3.0 -9999.0 0.0 3.0 RHOA 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 RhoA/GTP -0.005 0.038 -9999.0 0.0 -0.491 2.0 2.0 CTNNA1 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 VCL 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.011 0.018 -9999.0 0.0 -0.45 1.0 1.0 LPP 0.032 0.027 -9999.0 0.0 -0.273 1.0 1.0 Ephrin A1/EPHA2 -0.004 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.003 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.003 0.095 -9999.0 0.0 -0.293 49.0 49.0 HGF/MET -0.025 0.076 -9999.0 0.0 -0.48 1.0 1.0 HGF -0.039 0.161 -9999.0 0.0 -0.543 57.0 57.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.036 -9999.0 0.0 -0.26 10.0 10.0 actin cable formation 0.052 0.057 -9999.0 0.0 -0.353 5.0 5.0 KIAA1543 0.031 0.036 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.023 0.045 -9999.0 0.0 -0.286 11.0 11.0 NCK1 0.009 0.034 -9999.0 0.0 -0.59 2.0 2.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.029 0.022 -9999.0 0.0 -0.283 3.0 3.0 NCK1/GIT1 0.015 0.031 -9999.0 0.0 -0.428 3.0 3.0 mol:GDP -0.001 0.021 -9999.0 0.0 -0.301 3.0 3.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.029 0.022 -9999.0 0.0 -0.283 3.0 3.0 PIP5K1C 0.028 0.025 -9999.0 0.0 -0.284 4.0 4.0 LIMA1 0.005 0.063 -9999.0 0.0 -0.59 7.0 7.0 ABI1 0.01 0.024 -9999.0 0.0 -0.59 1.0 1.0 ROCK1 0.039 0.059 -9999.0 0.0 -0.479 4.0 4.0 adherens junction assembly 0.036 0.072 -9999.0 0.0 -0.43 9.0 9.0 IGF-1R heterotetramer/IGF1 -0.038 0.089 -9999.0 0.0 -0.564 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.014 0.033 -9999.0 0.0 -0.399 4.0 4.0 MET 0.009 0.039 -9999.0 0.0 -0.543 3.0 3.0 PLEKHA7 0.028 0.025 -9999.0 0.0 -0.284 4.0 4.0 mol:GTP 0.023 0.044 -9999.0 0.0 -0.373 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.046 0.029 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.021 0.036 -9999.0 0.0 -0.258 10.0 10.0 regulation of cell-cell adhesion 0.032 0.026 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.036 -9999.0 0.0 -0.26 10.0 10.0