E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.016 0.039 -9999.0 0.0 -0.309 6.0 6.0 KLHL20 0.035 0.084 0.198 31.0 -0.231 29.0 60.0 CYFIP2 0.018 0.061 -9999.0 0.0 -0.452 10.0 10.0 Rac1/GDP 0.058 0.088 0.262 10.0 -0.342 2.0 12.0 ENAH 0.012 0.05 -9999.0 0.0 -0.321 7.0 7.0 AP1M1 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 RAP1B 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.012 0.031 -9999.0 0.0 -0.266 2.0 2.0 ABI1/Sra1/Nap1 -0.012 0.04 -9999.0 0.0 -0.167 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.058 -9999.0 0.0 -0.244 18.0 18.0 RAPGEF1 0.053 0.086 0.285 9.0 -0.331 4.0 13.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.025 0.041 -9999.0 0.0 -0.314 6.0 6.0 CRK 0.054 0.081 -9999.0 0.0 -0.364 2.0 2.0 E-cadherin/gamma catenin/alpha catenin 0.049 0.029 -9999.0 0.0 -0.278 4.0 4.0 alphaE/beta7 Integrin 0.023 0.064 -9999.0 0.0 -0.315 20.0 20.0 IQGAP1 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 NCKAP1 0.025 0.027 -9999.0 0.0 -0.452 2.0 2.0 Rap1/GTP/I-afadin 0.047 0.021 -9999.0 0.0 -0.252 2.0 2.0 DLG1 0.015 0.042 -9999.0 0.0 -0.309 6.0 6.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.021 -9999.0 0.0 -0.226 2.0 2.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.033 0.068 -9999.0 0.0 -0.25 30.0 30.0 PI3K -0.011 0.027 -9999.0 0.0 -0.294 2.0 2.0 ARF6 0.024 0.02 -9999.0 0.0 -0.452 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.037 0.022 -9999.0 0.0 -0.326 2.0 2.0 TIAM1 0.006 0.106 -9999.0 0.0 -0.452 30.0 30.0 E-cadherin(dimer)/Ca2+ 0.058 0.026 -9999.0 0.0 -0.239 3.0 3.0 AKT1 0.018 0.049 0.094 26.0 -0.229 2.0 28.0 PIK3R1 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 CDH1 0.026 0.02 -9999.0 0.0 -0.452 1.0 1.0 RhoA/GDP 0.07 0.091 0.304 10.0 -0.342 2.0 12.0 actin cytoskeleton organization 0.031 0.066 0.165 36.0 -0.169 28.0 64.0 CDC42/GDP 0.066 0.092 0.294 12.0 -0.342 2.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.02 -9999.0 0.0 -0.227 4.0 4.0 ITGB7 0.012 0.086 -9999.0 0.0 -0.452 20.0 20.0 RAC1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.063 0.028 -9999.0 0.0 -0.255 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.044 0.022 -9999.0 0.0 -0.236 3.0 3.0 mol:GDP 0.062 0.099 0.29 15.0 -0.399 2.0 17.0 CDC42/GTP/IQGAP1 0.03 0.037 -9999.0 0.0 -0.393 4.0 4.0 JUP 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 p120 catenin/RhoA/GDP 0.079 0.092 0.307 10.0 -0.349 2.0 12.0 RAC1/GTP/IQGAP1 0.03 0.021 -9999.0 0.0 -0.274 2.0 2.0 PIP5K1C/AP1M1 0.038 0.026 -9999.0 0.0 -0.587 1.0 1.0 RHOA 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 CDC42 0.022 0.039 -9999.0 0.0 -0.452 4.0 4.0 CTNNA1 0.024 0.028 -9999.0 0.0 -0.452 2.0 2.0 positive regulation of S phase of mitotic cell cycle 0.028 0.051 0.137 43.0 -0.117 25.0 68.0 NME1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.015 0.04 -9999.0 0.0 -0.309 6.0 6.0 regulation of cell-cell adhesion 0.007 0.025 -9999.0 0.0 -0.215 3.0 3.0 WASF2 0.009 0.031 -9999.0 0.0 -0.114 5.0 5.0 Rap1/GTP 0.073 0.077 0.301 5.0 -0.289 2.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.062 -9999.0 0.0 -0.234 20.0 20.0 CCND1 0.031 0.06 0.155 41.0 -0.143 25.0 66.0 VAV2 0.049 0.184 0.355 2.0 -0.645 32.0 34.0 RAP1/GDP 0.079 0.087 0.312 9.0 -0.403 1.0 10.0 adherens junction assembly 0.013 0.041 -9999.0 0.0 -0.3 6.0 6.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.019 -9999.0 0.0 -0.452 1.0 1.0 PIP5K1C 0.025 0.02 -9999.0 0.0 -0.452 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.041 0.056 -9999.0 0.0 -0.226 20.0 20.0 E-cadherin/beta catenin 0.012 0.02 -9999.0 0.0 -0.301 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.009 0.036 -9999.0 0.0 -0.335 4.0 4.0 PIK3CA 0.025 0.027 -9999.0 0.0 -0.452 2.0 2.0 Rac1/GTP -0.014 0.088 -9999.0 0.0 -0.373 29.0 29.0 E-cadherin/beta catenin/alpha catenin 0.05 0.025 -9999.0 0.0 -0.278 3.0 3.0 ITGAE 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.041 -9999.0 0.0 -0.32 6.0 6.0